Parker Life Science News 1/2014

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Pääkirjoitus

Oikein hyvää uutta alkanutta vuotta kaikille lukijoillemme!

Alkanut vuosi lupailee uutisillaan hyvää terveysteknologian alalle Suomessa. Ympärillä kuuluu positiivisia kasvura-hoitusuutisia aloitteleville yrityksille ja yritysten kansainvälistymiseen. Lää-keteollisuuden puolella on käynnissä isoja investointeja Suomeen. Hihat siis heilumaan ja luomaan kasvua Suomen terveysteknologian teollisuudelle.

Tämän vuoden ensimmäinen Life Science News on hieman edellisiä numeroitaan paksumpi. Haluamme tarjota teille entistäkin kattavamman tietopaketin Parkerin Life Science teknologioista ja tuoteuutuuksista tälle kasvavalle ja kehittyvälle alueelle. Olemme jaotelleet lehteä lukemisen helpottamiseksi kolmeen eri pääotsik-koon, jotka on merkattu värikoodeilla:

Medical Technology Solutions

Clinical Diagnostic and Lab Instru-mentation Solutions

Pharmaceutical Solutions

Värikoodit löytyvät kyseisten sivujen sivun laidassa. Tämä sama jaottelu

ja värikoodaus toistuu myös uudessa käyttäjäystävällisessä sähköisessä ja interaktiivisessa katalogissamme, joka auttaa sinua löytämään tuotteemme ja ratkaisumme sekä palvelumme lääke-tieteellisten, laboratoriodiagnostisten ja analyyttisten laitteiden kehitystyö-hön ja valmistukseen sekä lääkekehi-tykseen. Toivottavasti olet jo ehtinyt tutustumaan katalogiimme. Lehden takasivulta löydät lisätietoa uudesta katalogistamme.

Olemme vihdoin saaneet lunta ja pakkasta koko Suomeen, joten nau-titaan nyt alkaneesta talvesta. Näin uuden vuoden ensimmäisinä viikkoina ajatukset kuitenkin karkaavat jo kevää-seen. Tästä vuoden ensimmäisestä Life Science Newsistä löydät uutena osiona tämän alan messut ja tapahtumat maailmalla kevään aikana. Tulethan piipahtamaan Parkerin ständillä, mis-säpäin maailmaa oletkin liikkeellä.

Toivotan kuulasta talven jatkoa ja kaikkea hyvää vuodelle 2014!

Minna GröningSales Manager

Parker Life Science News 1/2014

Kustantaja: Parker Hannifin Oy Koivupuistontie 18-22 01510 Vantaa Puh. 0207 532 500 www.parker.com

Päätoimittaja: Minna GröningUlkoasun toteutus: ammattilehti.fi

Painopaikka: Kirjapaino Prodo Oy

Parker Life Science News 1/2014

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Sisällysluettelo

4. Products that help to protect lives

7. Parker Announces New Micro

Diaphragm Pump for Small Portable Negative

Pressure Wound Therapy Medical Devices

8. Benefits of Using a Micro Pumps and

Miniature Valves in Sidestream Capnography

11. Nitrogen Generators for LC/MS:

Flow Capacities up to 60 lpm

12. INNOVATIVE BLOOD ANALYZER

SOLUTIONS that help ensure

successful blood transfusions

13. Trusted Solutions for Blood Analyzers

14. Risk management

17. Scalable Solutions

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Products that help to protect livesAdvanced components and systems for medical technology and pharma-ceutical uses that combine safety and economy

Author: Berthold Röhrich, Market Manager Life Sci-ence, O-Ring Division Europe

Products for the wide and varied spectrum ofthe so-called Life Sciences

(LS), in the industrial context, encompass components and systems used

particularly in medical technology and the pharmaceutical sector. Due

to their direct effects on the life and health of patients they are subject

to especially stringent requirements. Parker-Prädifa, in addition to an

extensive portfolio of existing solutions, offers customers the opportunityfor

bespoke new developments in close system and development partnerships

with them. Unlike many suppliers, Parker can draw on both elastomeric

and thermoplastic materials for these comprehensive solutions.

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5 Material selection and optimisation

The demands which “classic” indus-trial applications make on materials, such as resistance against media or extreme temperatures, do not, or just rarely, occur in the case of LS products. Instead, the proper selection or “re-finement” of the materials is of central importance here.

This is done on the basis of customer- or application-specific criteria, with biocompatibility (see also article on page 8 of this issue), e.g. according to USP Class 6 or ISO 10993, is typically the main aspect. In this context, Park-er-Prädifa of course supports custom-ers in performing E&L(Extractables & Leachables) analyses as well.

In addition, the planned conversion of the materials into components and systems, for example using injection moulding, extrusion, compression or over-moulding technologies, plus the sterilisation methods intended for subsequent use play an important part in the selection of materials.

The optimisation of material properties to meet application-specific require-ments is another key factor. Typical examples are anti-microbial effects to minimise the risk of infection in clini-cal applications, the optimisation of surfaces with respect to friction in dy-namic applications as well as changes concerning hydrophobic properties.

Design

With respect to the design of moulded elastomeric parts, Parker-Prädifa supports customers in the medical technology sector and the pharma-ceutical industry by using powerful FiniteElementAnalyses (FEA). A case in point is the simulation of how a sili-cone valve mechanism performs when mechanically activated at different degrees of material hardness or critical mass variances on the component that was performed in order to find the best possible combination.

From the initial idea through to pro-

duction and assembly, Parker-Prädifa develops comprehensive, customised solutions and, as previously men-tioned, covers both elastomeric and thermoplastic components. In contrast to dealing with manufacturers that specialise in just one of these materi-als, this gives customers the benefitof receiving a wider range of solutions from a single source. Only few suppli-ers in the marketplace have the capa-bilities to provide this advantage.

System and development partnership

For new LS product developments, Parker-Prädifa has been able to file numerous patents lately. Close col-laboration in a spirit of partnership with the customer and a constant ex-change of ideas and possible solutions, particularly in the concept phase, are indispensable prerequisites for any new development of this kind. For the customer, this type of development and system partnership means being able to substantially save development time and costs. Faster time to market combined with lower development costs, especially in today’s extremely competitive environment in the medi-cal technology and pharmaceuticals markets is crucial to sustained busi-ness success.

Economy

Economic aspects play a role as well when it comes to optimising systems,

Design optimisation by means of Finite Element Analysis

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6 for instance by two-component solu-tions where Parker-Prädifa’s main focus is placed on silicone and ther-moplastic materials. In line with the unbroken trend towards miniaturisa-tion, the size of all manner of devices continues to shrink. As a result, the manual assembly of components such as seals becomes more time-intensive and thus more costly. At the same time, the reproducibility of the prod-ucts must be assured at all times, with the “man and machine” factor and handling playing an important part within the tolerance chain.

This obviously suggests the use of tooling solutions. When choosing this option, the design of both compo-nents must be considered as well as the adhesion of the materials and the underlying tooling technology. How-ever, two-component solutions are typically cost-efficient only in the case of high production volumes, as the tools are costly compared with the use of conventional single components. Therefore, the specialists at Parker-Prädifa, together with the customer, will analyse the entire process from as-sembly through to packaging and work out the break-even point in view of the substantial investment costs.

Production and assembly

Parker-Prädifa is currently making a

major investment in the extension of its existing manufacturing capacities by establishing a new manufacturing cell with several clean room facilities at its Sadskásite.The aim is to centralise the entire production and assembly operations for Parker-Prädifa’s LS products in future, including the asso-ciated human resources, also in quality assurance and process engineering, at the Czech location.

Included in these operations are man-ufacturing facilities according to ISO Class 8 for injection-moulded compo-nents made of liquid silicone, rubber or thermoplastic elastomers (TPE), assembly and packaging according to ISO Class 7, warehouse logistics and secondary packaging according to ISO Class 9. In addition, assembly tech-nologies such as ultrasonic welding and riveting of plastic components plus over-moulding of tubes made, for example, from silicone and TPE, all in clean room conditions, are currently being extended.

Quality assurance

Apart from maximum safety, the trace-ability and identification of materi-als used in LS products is of central importance. Therefore, processes and technologies used at the manufactur-ing cell in Sadskà are designed accord-ing to GMP standards.

Validation and documentation

In addition to typical applications in medical technology, examples of which are shown in the separate over-view, another focus at Parker-Prädifais placed on single-use systems for biotechnological processes which, not least due to their higher economy and flexibility, are increasingly being used by the pharmaceutical industry.

Single-use systems are sterile assem-blies, typically consisting of a plastic container, a tube, a filter unit and joining components. Pharmaceutical companies use them in the production of vaccines, for example. As these as-semblies may come into direct contact with the media used in the system an appropriate validation of the entire assembly based on process-specific parameters is indispensable. This validation encompasses factors such as bio burden, particle count, integrity and sterility.

Packaged assemblies

In addition, Parker-Prädifa assists its customers in optimising various fluid handling processes as an expert manufactur-ing partner in the field of tube systems, joining technology and sample-taking systems. Apart from the appropriate clean room environment the selection, as previously mentioned, of the right system components and materials according to the relevant process parameters is a key factor. Different sterilisation processes play an equally important role in this context as the interactions with flow media. The use of a qualification matrix adapted to the individual system assures that all relevant standards (E.P. 3.1.9, USP, ISO 10993, FDA 21 CFR 177.2600) are met.M

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Parker Announces New Micro Diaphragm Pump for Small Portable Negative Pressure Wound Therapy Medical DevicesA new micro diaphragm pump from the Precision Fluidics Division of Park-er Hannifin Corporation, the global leader in motion and control technolo-gies, is specifically designed for the needs of portable medical devices for advanced wound care.

The Parker T2-05-IC micro diaphragm pump provides the negative pressure required to draw down the dressing over the wound area and to maintain a constant suction for effective wound healing. “After listening to the future requirements of our customers there is a need to develop advanced medical treatments for the millions of minor surgeries that are conducted around the world. Parker’s micro diaphragm pump operates as the vacuum source for the wound dressing system”, said Abelardo Gonzalez, Global Product

Manager. “Size, performance, and reliability are significant advantages with this pump,” explains Gonzalez. Advanced wound management devices are getting smaller for portability and increased patient comfort. The efficiency of these devices is critical because low power consumption and minimal vacuum losses allow battery packs to last long-er. This capability allows the patient to be more mobile; thus enabling a better quality of life. The Parker T2-05-IC is ideal for ap-plications such as single patient use negative pressure wound therapy (NPWT) devices that require multiple dressing therapy treatments and is CE and RoHS compliant, facilitating ease of integration into a medical device. Parker Precision Fluidics is a market leader in miniature, low power, light

weight, high performance fluidic prod-ucts. More information is available at www.parker.com/precisionfluidics/t5 or email ppfinfo@parker.com. With annual sales exceeding $13 bil-lion in fiscal year 2013, Parker Han-nifin is the world’s leading diversified manufacturer of motion and control technologies and systems, providing precision-engineered solutions for a wide variety of mobile, industrial and aerospace markets. The company em-ploys approximately 60,000 people in 48 countries around the world. Parker has increased its annual dividends paid to shareholders for 56 consecutive fiscal years, among the top five longest-running dividend-increase records in the S&P 500 index. For more informa-tion, visit the company’s website at www.parker.com, or its investor infor-mation website at www.phstock.com.

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Benefits of Using a Micro Pumps and Miniature Valves in Sidestream Capnography

Design Challenges

Capnography has continued to advance since its introduction in the 1950’s and it has rapidly become the standard of care in anesthesia and respiratory therapy.

Capnography is being used widely as a method for diagnosis and treatment beyond the operating room, including pre- and post-operative scenarios, as well as by first responders, in respira-tory therapy and in metabolic monitor-ing. Capnography helps verify endotra-cheal tube placement and monitor its position, assess ventilation and treat-ment, and evaluate resuscitative efforts during cardiopulmonary resuscitation (CPR). Capnography is non-invasive, easy to use, and offers great promise in the assessment of acute and critically ill patients.

The increased use and functionality of capnography has resulted in manufac-turers needing to enhance the devices with more complex technology includ-ing greater fluidic controls. Often these devices use two or more solenoid valves mounted on the PCB.

Multi-parameter patient monitors, anesthesia machines and ventilators incorporate advanced features such as: -Addition of portable capabilities -Ability to run on battery power -Need for sidestream CO2 OEM mod-ules Bottom line: These devices need com-

Introduction

Our bodies produce Carbon Dioxide (CO

2) as a result of cellular metabo-

lism. The circulatory system picks up the CO

2 and delivers it to the alveoli

of our lungs, where it is eliminated when we exhale. Medical profession-als such as anesthesiologists cap-ture and measure the exhaled CO

2,

displaying the results on a patient monitor typically referred to as a Capnometer or Capnograph.

Capnography measures the con-centration or partial pressure of CO

2

expelled in respiratory gases. It is used as a monitoring tool during the delivery of anesthesia and in the in-tensive care of patients. Capnography results display a graph of expiratory CO

2 plotted against time, or less com-

monly but more usefully, it shows the expired volume of CO

2.

There are two types of CO2 patient

monitors:

1. Mainstream Capnography uses an in-line infrared CO

2 sensor connect-

ed directly to the airway, between the endotracheal tube and the breathing circuit.

Example of a capnograph measured output

2. Sidestream Capnography pulls a sample of the patients’ exhaled gas from the breathing circuit through tub-ing to the infrared sensor located in a remote monitor.

Sidestream capnography requires a vacuum source, typically a diaphragm pump (sampling pump) that pulls a sample of the expired air from the patient’s breathing circuit, through a length of tubing, into the remote moni-tor and across the CO2 sensor. The CO2 sensor requires regular cali-bration to ensure sensor accuracy and system integrity. This is done through “auto-zeroing” the sensor by switching a solenoid valve in line with the sensor to expose it to ambient air. The sensor auto-zero valve acts to shut off flow from the system to the CO2 sensor in order for the sensor to self-calibrate. Depending on the complexity of the capnograph, the equipment can also include other solenoid valves that di-vert the airflow of the pump away from the sensor and perform a purge of the tubing to prevent occlusion. Parker Hannifin has developed several innovative fluidic control products that manufacturers can easily integrate into the development of sidestream capnography devices. These pump and valves address the constraints that engineers of sidestream capnography devices face when designing the next generation of patient monitors.

Typical Schematic of Sidestream Capnography Typical Schematic of Mainstream Capnography

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pact, high performance, low power pumps and valves.

Previous Options

Previously, the pneumatic circuitry in a capnograph used larger pumps such as Parker’s CTS Series or T2-03 and included larger solenoid valves such as Parker’s S-11 and V2.

The increased footprint made it more challenging for manufacturers to mount both the pump and the valve onto the PCB, especially when the de-vice required multiple valves. Although these components more than met the required performance in sidestream CO2, they are limited in power, size, weight, and ease of integration.

Parker Solution

Parker Precision Fluidics Division ad-dresses the evolving needs of patient monitor designers and OEM’s by con-tinuing to reduce the power required by its pumps and valves, while ensur-ing the highest performing fluidic components with the smallest size and weight.

The T2-05LI pump combined with our miniature X-Valve®:

-Eases integration concerns of fluidic components onto a PCB board -Increases the battery life of the instru-ment -Increases the reliability with pumps and valves -Extends the life of the medical device

Advantages of using Parker valves

and pumps in capnograph devices include: -Small Size -Low Power Consumption -Long Life -Simplified Supply Chain -Ease of Implementation

Small Size

Most next-generation medical devices trend toward smaller, more portable designs. In order to support this trend, system developers must evolve the corresponding technologies to meet these new performance needs.

Although the device size must de-crease to help reduce weight and facilitate portability, the performance requirements of the device, and by extension the components, should not diminish. This is the design challenge.

Parker designed the T2-05 LI pump and X-Valve solenoid valve with these new requirements in mind. As a result, the T2-05 LI pump has the highest flow rate to power consumption ratio on the market. This results in a sig-nificantly smaller and highly efficient pump that still meets the high flow rate needs of sidestream capnography devices.

Typical sidestream CO2 fluidic path with Parker’s T2-05LI pump and X-Valve

SIDE STREAM CAPNOGRAPHY DIAGRAM

The X-Valve, at just 8mm wide and 23.5mm long has a very compact form that enables portability and smaller overall device size.

Pumps commonly used in sidestream capnogra-phy applications (T2-05 LI Series

Is in the center)

Valves commonly used in sidestream capnogra-phy applications (X-valve is

In the center)

Low power consumption

Along with small size, low power consumption is also needed to enable portability while eliminating the need to frequently replace a device’s batter-ies.

In order to provide a product that meets the functional requirements of the application while consuming the minimum power possible, developers must optimize the design of compo-nents to obtain the highest possible efficiencies.

Parker designed the T2-05 LI pump to consume 0.36 Watts if operated at full voltage and the X-Valve to consume only 0.5 Watts. Together, the T2-05 LI pump and X-Valve provide two major fluidic components in sidestream capnography for less than 1 Watt of total power consumption. This mini-mum power usage results in longer battery life and extends the portable range of the system.

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Long life

As healthcare costs continue to rise, device manufacturers are designing for longer device life expectancy; however, a device’s life capability is only as good as its weakest components. Conse-quently, component life is fast becom-ing a limiting design requirement in component selection. With longer life expectancy needed in sidestream capnographs, OEMs must find pumps capable of operation rat-ings in excess of 5000 hours of use. The T2-05 LI pump has been successful in achieving this requirement given the generally low load (vacuum) levels used in sidestream capnography. The T2-05LI pump is rated to 6000 hours of operation and can achieve 10,000 hours or more with the T2-05 HE versiondependent upon the system operating conditions.

The X-Valve, which is commonly used for calibration of the CO

2 sensor, is

rated for 25 million cycles of opera-tion. Given the infrequency of sensor calibration over its life, the X-Valve far exceeds the life requirements of the capnography module.

Simplified Supply Chain

Parker Precision Fluidics Division has over 30 years of pump and valve com-petency and application knowledge of designing fluidic components and systems for manufacturers of patient monitors, anesthesia, ventilators and other respiratory devices around the world.

Parker is the only company that can design and manufacture pumps, valves, filters, tubing, fitting and all fluidic components—simplifying the supply chain, logistics and total overall costs. With a single solution provider that can design, prototype, and manu-facture, our customers benefit from shortened design and production cy-cles. By working with a lean enterprise, manufacturers can simplify procedures and enjoy convenient customer service and one point of contact.

Implementation

When developing a system, engineers are frequently faced with the obstacle of effectively coordinating the integra-tion of several sub-components into a functional layout. Components that are large and not well designed for easy integration with other components will further increase the challenge an engineer has to manage.

Ease of component integration is a core engineering philosophy at Parker, enabling our customers’ engineers to focus on their system functionality and not on the problem of neatly integrat-ing a system’s components together.

As can be seen in the following ex-ample, Parker designed the T2-05 LI pump and X-Valve to easily integrate both mechanically and electrically onto a PCB board, minimizing the overall system footprint and ensuring efficiency in system assembly.

Summary

Parker solves the challenge of combin-ing miniaturization, low power, and high performance in capnography applications.

Sidestream CO2 monitors require a

micro-diaphragm sampling pump to pull a sample of the expired air from the patient’s breathing circuit across a CO

2 sensor. Parker’s T2-05 LI pump

incorporates a highly efficient design requiring minimal power, long life, and low noise. It meets the demanding performance levels for flow, pressure

and vacuum control needed in cap-nography technology.

The X-Valve is an ideal switching sole-noid valve for sensor auto calibration, purge and occlusion prevention.

The small size and weight of T2-05 LI and the X-Valve is ideal for portable applications and manufacturers can easily mount the valve directly onto the PCB in a CO

2 module, even when the

device requires multiple valves. The low power design extends the battery life of these patient monitors.

The T2-05 LI and X-valve replaces larg-er pumps and valves previously used in the life sciences marketplace with a compact, efficient valve and pump, reducing the overall space required. Parker provides the ability to simplify logistics by being the only manufac-turer of both pumps and valves. The ability to partner with a global fluidics expert who understands the complex-ity of life sciences applications reduces a manufacturer’s risk and time to mar-ket, and helps ensure a device with the highest level of performance.

For more information regarding the T2-05 LI Micro-Diaphragm pump or the X-Valve Miniature Solenoid Valve please email ppfinfo@parker.com or read more product details on the web: http://www.parker.com/precisionflu-idics/t5 http://www.parker.com/precisionflu-idics/xvalve

Sidestream capnography mod-ule with Integrated T2-05 LI and

X-Valve

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Nitrogen Generators for LC/MS: Flow Capacities up to 60 lpm

Background:

For labs using multiple LC/MS instru-ments, demand can make sizing a generator difficult. The Parker Balston NitroFlow 60 is a self contained gen-erator that produces up to 60 slpm of pure LC/MS gradenitrogen at pressure of up to 100 psig,capable of supplying up to 3 instru-ments with LCMS grade nitrogen. The NitroFlow 60 is also available with an integrated membrane dryer for use with instruments that require dry air, including the chip cube interface from Agilent Technologies.Typical applications include LC/MS, nebulizer gases for APCI and ESI, Jet Stream, I Funnel, ELSD, Turbo Vaps, and chemical solvent evaporation.

Application

An LC/MS requires a reliable source of nitrogen as the curtain gas. Due to cost and the nature of tests being performed, customers expect 100% run time for this equipment. Replacing cylinders or dewars in labs with mul-tiple pieces of nitrogen fed equipment becomes impracticable due to regu-larity or large demand. Cylinders and dewars must be constantly monitored and refilled and have several associat-ed safety risks. The Nitroflow 60 allows for as needed and on demand nitrogen production using a combination scroll compressor and nitrogen membrane separation technologies.

Features and Benefits:

- Complete “plug and play” system recommended for all major LC/MS instruments- Phthalate-free, no organic vapors- Produces a continuous supply of nitrogen for all LC/MS applications- Eliminate dangerous nitrogen cylin-ders from the laboratory- Nearly silent operation; operates at less than 49 dB(A)- Less compressor maintenance due to fewer moving parts

The scroll compressor helps to elimi-nate excess noise from labs that would normally come from vacuum pumps and compressors. In small enclosed areas, the noise from vacuum pumps and compressors has a cumulative noise effect and creates an unsafe working environment. Operating at a low decibel level (49 dbA), the Nitro-Flow 60 is virtually inaudible and helps keep noise levels within a safe range for lab personnel.

The nitrogen membrane permits oxy-gen and water vapor to permeate while nitrogen flows through the fiber and to the application. This combination yields the highest performing, most re-liable, and quietest integrated nitrogen generation system available.

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INNOVATIVE BLOOD ANALYZER SOLUTIONS that help ensure successful blood transfusions

One Partner.Multiple Options.

Want to minimize transfusion reac-tions for patients? Think Parker. Our broad platform of precision liquid handling and motion control solu-tions – along with our ability to design and manufacture complex,integrated assemblies – enable device makers to offer diagnostic instruments that en-hance the typing, cross-matching, and screening of blood.

From our Smart Syringe Pump with best-in-class resolution … to dis-posable in-line filters, control valve assemblies and more, our breadth of technology allows us to deliver:

-System solutions that streamline the dispensing and aspirating of samples and reagents through accurate, repeat-able positioning-Inventive approaches that are smaller, lighter, quieter, and more reliable

Whether for gel card agglutination, solid-phase immunoassay, or nucleic acid test systems, our ability to design, prototype, and manufacture shortens the design cycle. Adding integration, innovation, and efficiency, as well as a global network of local resources to optimize the supply chain and speed throughput.

Innovative Solutions for:

-Gel card agglutination analyzers-Solid-phase immunoassay analyzers-Nucleic acid-based analyzers-Centrifuge instrumentation-Automated storage and retrieval systems

Parker Capabilities:

-Rapid prototyping-Custom components and assemblies-Integrated solutions-FEA – finite element analysis-CFD – computational fluid dynamics- Logistics management

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Trusted Solutions for Blood Analyzers

FLUIDIC SOLUTIONS

• Electronic pressurecontrollerSets and maintainssystem pressure for airover liquid dispensing/aspirating.

• Miniature diaphragm pumps,air and/or liquidGenerate systempressure forthe dispensing/aspirating of airand/or liquid.

• Miniature inertliquid valveIdeal for biocompatibilityand aggressive solutionssuch as bleach usedin wash cycles.

• Miniature diaphragmpumps, liquidGenerate vacuum forliquid waste removal.

• Miniature diaphragmpumps, airVacuum out purifiedDNAonto PCR plate.

• Miniaturesolenoid valvesTwo- and threewayvalves controlair and liquiddelivery circuits.

Email: diagnostics@parker.comwww.parker.com/diagnostics

Recognized worldwide as a leader in motion control technologies and fluid management systems, Parker is a trusted, collaborative partner of major im-munohematology instrument manufacturers.

MOTION CONTROL/HMISOLUTIONS

• Linear mechanicsand controlsPosition systemsfor handling ofplates, gel cards,samples, andreagents.

• Frameless kitservomotors andcontrolsCentrifuge motor andcontrol solutions.

• Xpress HMI panelsConfigure instrumenttests; display results.

FILTRATION

• Disposable filter unitsRemove contaminants,preventing crosscontamination of samples.

SEALING SOLUTIONS

• EMI shieldingOptically enhanceddisplay screens,conductive elastomers,coatings, plastics, andfoil laminates.

• Thermal managementThermally conductivematerials and heattransfer products forprinted circuit boards.

• Display enhancementand protectionPlastic and glass windows offering excellent mechanical chemical protection for demanding medical applications.

CONNECTOR SOLUTIONS

• Texfluor® smoothborePFA tubingOffers exceptional heatresistance combinedwith excellent chemicaland corrosion resistance. Available inultra pure resins.

• TrueSeal™ fittingsPush-to-connectthermoplasticfittings. Lightweightand reusable.Manufactured fromFDA compliant materials;NSF-51 listed.

INNOVATION IN ACTION:The Parker Smart Syringe Pump

At one-third the size ofstandard 30 mm syringepumps, the new ParkerSmart Syringe Pump offersimproved performance for clinical diagnostic and high throughput analytical chemistry laboratory automation:

Smaller footprint• One-third the size and the weight ofstandard 30 mm syringe pumps.Simplified instrument design• Direct mounting at the point ofdispensing improves performance byeliminating the need for a transferline.• CE compliant for emissions,immunity, and safety.Longer life• Five million cycles versus one millionfor nearest competitor.Superior performance• Best-in-class resolutions, 228, 500steps full scale, enabling smallersample and reagent volumes.• Non pulsatile flow down to7.5 nL/sec.

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Risk management

Controlling supply chain & process risk in bio-manufacturing

Ensuring patients receive the lifesav-ing pharmaceuticals they need, when they need them is of paramount importance to any biopharmaceutical manufacturer. With the industry still at a relatively early stage of its develop-ment, few molecules if any are manu-factured at a large number of global locations.

Biomanufacturers need to put into place all kinds of strategies to miti-gate risk and ensure their products are available for patients. Imagine the scenario whereby an insulin produc-tion facility is forced to shut down or production was to cease limiting the availability of insulin to diabet-ics around the world. Of secondary importance, though still to be consid-ered, is the resulting loss of sales for the manufacturer and a resultant drop in share price.

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‘Open Architecture’Parker domnick hunter is com-mitted to providing you with technology that fits your process rather than forcing you to adapt your process to available equip-ment; that’s the reason we have our ‘Open Architecture’ design philosophy. All SciLog systems, at every scale, feature ‘Open Architecture’design so whomever you choose as your filter supplier, we will work with you to deliver a system that exactly meets your requirements be it semi- au-tomated or fully-automated, single-use or multi-use. With ‘Open Architecture’ you can have all the benefits of automa-tion without having to com-promise on the best processing solution.

Scalable Solutions

R & D Pilot Plant GMP Manufacturing

SciLog PureTec® - Laboratory-Scale TFF System

Delivered as a complete development system, PureTec® TFF protein purifica-tion system automatically monitors and adjusts trans-membrane pressure (TMP) or cross flow rate to optimize product yield.

SciLog SciPure® GMP-ready TFF system

The SciPure® fully-automated bio-processing system features a user friendly interface and menu driven operation with data acquisition (21 CFR Part 11) making it ideal for GMP manufacturing.

SciLog SciFlex® TFF - bioprocessing system

SciFlex® TFF is a semiautomated bio-processing platform that is ideal for pi-lot level TFF processing and develop-ment, optimizing filtration speed and maximizing filter life and efficiency.

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Meeting the Biocompatibility Challenge in Respiratory Device DesignsDesign engineers f ace the challenge of improving system performance and capability, while they remain under constant pressure to reduce system cost. Meeting these challenges—along with meeting the need to comply with biocompatibility standards—is increasingly dif f icult in today’s global market.

Biocompatible component challenges

However, these engineers aren’t alone in f acing these challenges. They can work with strategic supplier partners that have the design and engineering expertise to provide biocompatible components that expand the bounda-ries of product design. These compo-nents can: -provide highly reliable and repeatable operation -reduce instrument size, weight, or power consumption -get products to market f aster, with lower overall system cost, without sacrif icing perf romance -meet the ever-evolving biocompat-ibility compliance requirements f or sensitivity and toxicity (USP Class VI, IEC 60601-2-13, ISO 10993)

OEMs turn to suppliers for design

When OEMs can rely on tested, state-of -the-art components that have been caref ully designed f or a widerange of lif e-science applications, they can optimize their own R&D budgets and expand medical deviceproduct design to deliver more value.

As a result, OEMs are increasingly turning to their suppliers f or this ex-pertise, as well as guidancepertaining to the latest regulatory requirements. A supplier of mission-critical parts like Parker PrecisionFluidics stays on top of the latest changes and designs its products ac-

cordingly—of ten beyond what iscurrently required.

The ideal part or component should not just meet the design engineer’s

ple, the Parker VSO-MIminiature proportion valve is the only one on the market that has been evalu-ated by registered laboratoriesto guidelines established within the ISO 10993-1:2009 matrix (www.iso.org) and USP (www.usp.org) regulatory standards f or biocompatibility.

Design with life sciences in mind

It will always be a design challenge to meet the requirements of consistent and repeatable perf ormance, evolving compliance standards, and increasing market pressure to reduce costs. One way OEMs can meet these challenges is by working with innovative suppli-ers that “design with lif e science use in mind” to create high-value compo-nents that can be used across a range of applications, in more creative ways.

Read more:blog.parker.com

requirements, but also exceed them. This means that the supplier must have deep knowledge of the end-use environment (f or example, portable medical or respiratory device), the expected product perf ormance, and the budget limits that its customers f ace. Smaller product dimensions (with the same tight tolerances), caref ul material choices (engineered plastics can provide a wide range of physical and chemical characteristics), lighter weight, and energyef f icient control valves can give design engineers more creativity in designing ventilators and other breathing-related products. This especially pertains to subassembly, mounting conf igurations, and use in harsher environments. Sturdier con-struction and low-power consumption also equates to lower maintenance requirements and longer, uninter-rupted perf ormance. Enhanced inter-connection f lexibility with miniature proportional valves, f or example, can support multiple voltage ranges and can provide multiple methods of con-nection (manif old mount or barbed), depending on the design.

Moreover, there is the security and peace of mind that is derived f rom knowing that these components/materials have already met sensitivity and toxicity biocompatibility require-ments—which alsospeeds up the validation process f or regulatory purposes (as well as time to market).

It is even more benef icial to meet both FDA and USP requirements. For exam-M

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Parker Life Science Suomessa

Parker Hannifin OyKoivupuistontie 18-22FI-01510 Vantaa

www.parker.com/medical

www.parker.com/pharma

lifescience.finland@parker.com

Myynti:

Minna Gröning

Sales Manager

Puh. 020 753 2212

minna.groning@parker.com

Asiakaspalvelu:

Jonna Pietilä

Customer Service Manager

Puh. 020 753 2304

parker.finland@parker.com

Asiakaspalvelu:

Eveliina Bruun

Key Account Coordinator

Puh. 020 753 2272

parker.finland@parker.com

Tekninen tuki:

Ville Karlsson

Tech Support Manager & Automaatiotuotteet

Puh. 020 753 2358

techsupport.finland@parker.com

Tekninen tuki:

Jouni Lindqvist

Suodatustuotteet; Domnick Hunter, Balston

Puh. 020 753 2320

techsupport.finland@parker.com

Trade Shows and Events 2014Start date Event name Location18.01. SLAS 2014 San Diego, USA11.02. MD&M West Anaheim, CA USA01.04. Analytica 2014 Munich, Germany02.05. Vascular Access for Hemodialysis Symposium Dallas, Texas USA07.05. MD&M Texas Texas, USA01.06. World Congress of Vascular Access (WoCoCA) Amsterdam, NL09.09. Medical Manufacturing Asia Singapore24.09. Analytica China Shanghai, China12.11. Medica Trade Fair Dusseldorf, Germany

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Together, we can create innovative medical devices so people get more out of life.

Tutustu uuteen sähköiseen tuotekatalogiimme osoitteessa www.parker.com/lifesciences/rg

www.parker.com/medical www.parker.com/pharma www.parker.com/diagnostics

METSÄALAN AMMATTILEHTI

www.parker.com 020-753 2500

Parkerilta löydät oikean kokoiset kiinteä- ja muuttuvatilavuuksiset pumput tarpeisiisi. Useiden vuosikymmenten tiivis yhteistyö vaativien käyttäjien kanssa varmistaa, että pumppumme toimivat luotettavasti ja tehokkaasti vaikeimmissakin ympäristöissä. Lujat ja toimintavarmat pumput ovat kuitenkin vasta alkua antoisalle asiakassuhteelle, sillä niiden lisäksi saat käyttöösi pätevän sovellusosaamisemme sekä paikallisen tuen kaikkialla maailmassa.

Yhteistyössä Parkerin kanssa lähes kaikki on mahdollista. Yhdessä pystymme luomaan tuottavampia, toimintavarmempia ja ympäristöä säästäviä koneita. Hiljaisempia, kompak-timpia, vähemmän kuluttavia ja kannattavampia koneita, jotka vahvistavat kilpailukykyäsi!

Yhdessä pystymme tekemään vaikeimmatkin työt.