NovioTech BV

Technology to the MarketFrom Glucose Sensor to Hydrogel

Hans Hanssen (CTO)

Presented 30 June 2011 to Valorisation UMC Radboud

About NovioTech BV

• Shareholders:• Tweehuysen Holding BV

• Hanssen Investment and Consultancy BV

• Prof. Jan van Hest

• Prof. Alan Rowan

• Scientific Advisor: Prof Roeland Nolte

www.noviotech.com

About the Speaker: Hans Hanssen

• Former CEO of MCTEC

• Co-Founder of DSE BV, Eyetube BV, MCTEC BV, NovioTech BV

• Business Advisor to EPFlex GmBH, Nano4Imaging BV, Encapson BV

Outline of the Talk

• NovioSense – Glucose Sensor Technology

• NovioHelix – Novel Thermogel Technology

Diabetes

• At this moment World Health Organization estimates 5-7% of the worldpopulation has diabetes.

• This will increase within the next 20 years to 300 million.

• Diabetes can lead to:

– Heart disease and stroke

– High blood pressure

– Blindness

– Kidney disease

– Nervous system disease (Neuropathy)

– Amputation

Standard sensors

• Involves finger-pricking for sampling

• Not-continuous monitoring

Concept sensor

AV

Counter Electrode

WorkingElectrode

ReferenceElectrode

Electrochemical reactions E°/VWE: H2O2 2H+ + O2 + 2e-0.695CE: 2H+ + ½O2 + 2e- H2ORE: Ag(s) + Cl- AgCl(s) 0.22233

y = 5.36E-07x + 2.10E-07

R2 = 9.96E-01

0.00E+00

1.00E-07

2.00E-07

3.00E-07

4.00E-07

5.00E-07

6.00E-07

7.00E-07

8.00E-07

9.00E-07

0 0.5 1

Glucose conc. (mM)

Cu

rre

nt

(A)

The resulting current is linear within the concentration regime of glucose levels in tear fluid

Semi-Continuous Glucose Monitoring

Sending signal to receiver in glasses

Amplifying signal and transmition to insulin pump

Project Status

Patent Pending: NovioTech Assignee

Contact with Major Players in the Glucose Management Industry

Raised €1.1M of Inter Regional Funding

Goal is Functional Prototypes in 12 Months From Now

Warm

Cool

Gel formation at up to 99.98% water

Programmable transition temperatures

Optically Transparent

Biocompatible

Forms Nano-Pores (100-250nm)

Stiffness from (10 - 1000Pa)

Market Opportunities Based on Bulk Properties

Low Hanging Fruit: NanoWipe

Contacts with Potential End Users (DSM Resolve) and Instrument Manufacturers (NanoSight UK)

3D Tissue Culture Medium

Wound Care

Project Status

Identified Dedicated Project Manager

Patent Pending: NovioTech has Exclusive License

Promising New Thermo Responsive Nano Material

Identify Most Promising Market Areas

Early Prototype NanoWipe

Proof of Principle BioMedical Applications Underway

Wound Management