Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin...
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Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1- antitrypsin by Bin Zhang, Chunlei Zheng, Min Zhu, Jiayi Tao, Matthew P. Vasievich, Andrea Baines, Jinoh Kim, Randy Schekman, Randal J. Kaufman, and David Ginsburg Blood Volume 118(12):3384-3391 September 22, 2011 ©2011 by American Society of Hematology
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Transcript of Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin...
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin
by Bin Zhang, Chunlei Zheng, Min Zhu, Jiayi Tao, Matthew P. Vasievich, Andrea Baines, Jinoh Kim, Randy Schekman, Randal J. Kaufman, and David Ginsburg
BloodVolume 118(12):3384-3391
September 22, 2011
©2011 by American Society of Hematology
Characterization of mice carrying the Lman1 targeted allele.
Bin Zhang et al. Blood 2011;118:3384-3391
©2011 by American Society of Hematology
FV and FVIII levels in Lman1 WT (+/+), heterozygote (+/−), and homozygous (−/−) mice.
Bin Zhang et al. Blood 2011;118:3384-3391
©2011 by American Society of Hematology
Budding of COPII-coated vesicles is not affected by LMAN1 deficiency.
Bin Zhang et al. Blood 2011;118:3384-3391
©2011 by American Society of Hematology
ER morphology and expression of UPR markers in WT (+/+) and Lman1−/− cells.
Bin Zhang et al. Blood 2011;118:3384-3391
©2011 by American Society of Hematology
Plasma and liver AAT levels.
Bin Zhang et al. Blood 2011;118:3384-3391
©2011 by American Society of Hematology
