METHYL ALCOHOL

Methanol Added to industrial rectified spirit - render it

unfit for drinking.

Methylated spirit(denatured spirit) is 5 parts of wood naphtha added to 95 parts of

rectified spirit.

It is tinted blue by methylene blue-identification.

Manufacturing of chemicalsDenaturing agentSolvents in laboratoryFuel It can be applied on skin for the following As antiseptic For cleaning Astringent purposes

USES

Metabolism of Methanol

Methanol Poisoning• Mixing of methylated spirit with alcoholic

beverages or its inadvertant ingestion –poisoning.

• Blood level>50mg/dl- severe poisoning 15ml methanol-blindness 30ml methanol-death 75-100ml-fatal dose• Toxic effect-folate

ManifestationsInitial symptoms:• Central nervous system depression• Headache• Dizziness and disorientation• Confusion• Nausea and vomiting• Epigastric pain• Delirium and seizures leading to coma may occur.

Second set of symptoms:

Blurring of vision-blindnessAcidosis

Respiratory failure-Death

Signs•Tachypnoea•Dyspnoea•Bradycardia•Hypotension

TREATMENT Keep the patient in dark room

Gastric lavage with sodium bicarbonate.

Sodium bicarbonate i.v infusion-combat acidosis

Potassium chloride infusion

Ethanol treatment-competitive inhibition

Haemodialysis- clears methanol and formate

Fomepizole-inhibit alcohol dehydrogenase - 15mg/k[loading dose] 10mg/kg/12hr - longer half life ,no inebriating action compared to ethanol

Folate therapy-Calcium leucovorin 50mg/6hr

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