Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview •...
Transcript of Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview •...
![Page 1: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/1.jpg)
Medical mycology
• Overview• Pathogenic Fungi• Opportunistic fungi• Cutaneous• Intoxication
Tinea pedis : Athlete;s foot
![Page 2: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/2.jpg)
Epidemology
• 100,000 spp of fungi• <200 cause disease in humans• Most not contagious,• Except dermatophnytes• Spores• Hard to treat, eukaryotic cells• Not reported so do not know the extent in
the human population
![Page 3: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/3.jpg)
Clinical manifestations
• Fungal infections– most common
• Toxicoses– poisoning through ingestion
• Allergies– hypersensitivity reactions
• Diagnostic– sabouraud dextrose agarKOH
![Page 4: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/4.jpg)
Treatment
• Membrane has ergosterol not cholesterol• Target synthesis• Amphotericin B– treat systemic mycoses,
very toxic to humans• Azoles – less toxic, fungistatic• 5-Fluorocytosine inhibits RNA and DNA
synthesis
![Page 5: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/5.jpg)
Fungal pathogens
• Actively attack and invade tissue
• Dimorphic forms
Figure 22.2 - Overview
![Page 6: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/6.jpg)
Distribution of fungal pathogens
![Page 7: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/7.jpg)
Table 22.1
![Page 8: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/8.jpg)
Candidiasis--opportunistic
Figure 22.10 - Overview
![Page 9: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/9.jpg)
Table 22.2 (2 of 2)
![Page 10: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/10.jpg)
Table 22.3
![Page 11: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/11.jpg)
Figure 22.13
![Page 12: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/12.jpg)
Amanita phalloides—death cap
Contains: phalloidin which binds actin and alpha-amanitin which Inhibits mRNA synthesis. Cause liver damage Figure 22.19
![Page 13: Medical mycology - WOU Homepageguralnl/gural/318fungi.pdf · Medical mycology •Overview • Pathogenic Fungi • Opportunistic fungi • Cutaneous • Intoxication Tinea pedis :](https://reader034.fdocument.pub/reader034/viewer/2022051600/5a9ba27e7f8b9ad96f8e1fe6/html5/thumbnails/13.jpg)
UN 22.1