Mastering+Autism

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A Comprehensive Guide to Mastering Autism,Autoimmune, and Other Neurological Disorders

Formerly, To Infuse or Not to Infuse and A Comprehensive Guide to Managing Autism

Willis S. Langford

Copyright November 1999-2011


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Mastering Autism!do" #May $%, $&''(

A Comprehensive Guide to Mastering Autism

TABLE OF CONTENTSSubject Page

Introduction...1Immune 101.................!Lea"# $ut............................................................................................................%&'ige(tion 101. .%)Serotonin Connection........................................................................................11&*ea+ing t,e Lea"# $ut.......................................................................................1-&$ABA...............................................................................................................1-Candida..............................................................................................................1&/A Second Scenario............................................................................................1!Coer,ead(......................................................................................................1/0*......................................................................................................................1/&'r. C,ene#( O2#gen Treatment .......................................................................1/&Tran(3er Factor..................................................................................................1)0Negati4e E33ect( o3 Secretin..............................................................................1)1*#droc,+oric Acid 5a# be a So+ution...............................................................1)&Bioc,emica+ Ob(er4ation(.................................................................................1))So+ution( to t,e Prob+em(..................................................................................1%

*i(tamine6 So+ution or Prob+em7.......................................................................1/En8#me(6 T,e Fountain o3 Li3e.........................................................................1%Imro4ed Nutrition 9e+ie4e( Bo:e+ and In3ection............................................1Care and Feeding o3 t,e Bo:e+.........................................................................!0!Some additiona+ aid( to o4ercome diarr,ea6......................................................!0/Cod;+i4er Oi+ and


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A Comprehensive Guide to Mastering Autism

Willis S. Langford

Warning: Do not scan and read this paper piecemeal. It must be studied to avoid mis-steps.

Use FIND, COPY, and PASTE to extrat !a!agra!"s of interest into a ne#, s"orter do$%ent for &etter orrelation.

Auti(m can be ma(tered T,ere are (e4era+ 4er# ba(ic t,ing( di(cu((ed in t,i( aer t,at can be done at,ome :it, +itt+e or no e2en(i4e te(ting. Foremo(t i( t,e ,ome te(ting 3or t,#roid 3unction di(cu((edto:ard t,e end o3 t,i( aer and (uort o3 t,#roid 3unction. T,e un+oading o3 t,e don"e#D i( 4ita+ too((ib+# %0 o3 t,e(e troub+ed c,i+dren 3or t,e# are oi(oned dro:ning in t,eir o:n to2ic :a(te(.E+imination o3 bo:e+ di(order( i( 4er# 3ir(t on t,e +i(t o3 4ita+ action. It i( o3ten a( (im+e a( (u+#ing adige(ti4e en8#me (u+ement or remo4ing mi+". A 3e: auti(tic c,i+dren can be ,e+ed dramatica++# b#medica+ rocedure( (uc, a( an in3u(ion o3 t,e inte(tina+ ,ormone Secretin but b# and +arge :e aredea+ing :it, a to2ic condition reuiring bioc,emica+Gdietar# not drug;ba(ed inter4ention.

T,e need and t,e bene3icia+ re(on(e to Secretin treatment I t,in" are deendent uon t,e amount o3 damage to t,eduodenum and (ma++ inte(tine and on t,e (tomac,( abi+it# to roduce adeuate ,#droc,+oric acid ?*C+@ 3or roerdige(tion. Additiona++# the WG le!tin of "heat #gl$ten%gliadin& "as sho"n to red$!e Se!retin prod$!tion by

'()* ho"ever+ administration of '00 mg of N-a!etylgl$!osamine t"i!e a day #preferably at beginning of themeal& !ompletely s$ppressed this effe!t,Since t,e(e 3actor( +arge+# determine roer dige(tion and a((imi+ation it i(4ita+ t,at a++ (#(tem( be 3unctioning otima++#. *ea+ing o3 t,e inte(tine( inc+uding reba+ancing o3 3+ora i( 4ita+ to ,ea+t,and :e++;being and menta+ 3unction. 9e+ea(e o3 Secretin i( deendent on adeuate *C+ in t,e c,#me and uon t,ebinding ?neutra+i8ation@ o3 Lectin( 3ound in grain( and +egume( in articu+ar. Secretin i( reduced in ,#ot,#roid rat(?9obberec,t et a+ 1%1@H (o (uort t,e t,#roid and bind ?or remo4e@ t,e +ectin( ?more +ater@. =it,out adeuate *C+Secretin in3u(ion can at be(t be on+# artia++# e33ecti4e in re(toring dige(tion and roer ,#(ica+ and menta+ 3unction.*C+ roduction and t,#roid 3unction are a+(o 4er# deendent on adeuate 8inc +e4e+( u(ua++# +ac"ing in t,e(ec,i+dren. T,i( +ac" o3 8inc ma# +ead to ("in condition( +o(( o3 ta(te neuro(#c,iatric (#mtom( (+ee rob+em( ande4en t,e (ure((ion o3 gro:t,. An ad4anced 8inc de3icienc# i( indicated b# :,ite (ec"( or (ot( on 3ingernai+(. =it,(uort 3or t,e t,#roid neutra+i8ing o3 +ectin( ?N;acet#+g+uco(amine neutra+i8e( t,e =$A o3 :,eat and a+(o t,e

otato +ectin@ adeuate 8inc and 4itamin B/inta"e (u+ementa+ betaine ,#droc,+oride ?*C+ :,ere needed@'5AE andGor Bet,anec,o+ Secretin in3u(ion ma# be tota++# unnece((ar#.

T,e at, o3 auti(m i( di33erent 3or eac, c,i+d. Some are rone to (ei8ure( (ome are notH (ome be,a4eaggre((i4e+# ot,er( are o4er+# a((i4e. *o:e4er c,i+dren :it, auti(m and :it, A'*' (,are (e4era+3actor(. In one (tud# // o3 atient( diagno(ed :it, A'*' :ere 3ound to be ,#ot,#roid ?at +ea(t a(man# :it, auti(m are ,#ot,#roid@. Suorting t,eir t,#roid +e4e+( :a( +arge+# curati4e.


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3ran" aranoia mood (:ing( and aggre((ion. T,#roid ,ormone di(order( ma# induce a+mo(t an#(#c,iatric (#mtom or (#ndrome inc+uding rageDJAron(on and 'odman 1).

5ood( and be,a4ior are +arge+# in3+uenced b# t,e ratio o3 3i4e centra+ ner4ou( (#(tem c,emica+( "no:n a(amine(. T,e(e inc+ude6 noreine,rine ?noradrena+ine@ eine,rine ?adrena+ine@ (erotonin ?;*T@doamine and ,en#+et,#+amine ?PEA@. T,e 3ir(t t,ree e2cite t,e CNS ?centra+ ner4ou( (#(tem@ :,i+e t,e+a(t t:o in,ibit or modu+ate t,at e2citement. T,e ratio o3 t,e(e amine( contro+( our +e4e+( o3 irritabi+it#.

Kiro4 ,a( ob(er4ed an a((ociation bet:een (e4erit# o3 an2iet# or dere((ion and +o: +a(ma 5agne(ium?5g@. P+i(8"a and 9ogene(( mea(ured (erum 5g in 1/ bo#( admitted to a (#c,iatric ,o(ita+ and 3ound+o: 5g +e4e+( to be a((ociated :it, d#(,oric mood and (+ee di(order(. For a detai+ed (tud# a(" 3or5anaging


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)G!&G0/. T,i( o2idati4e (tre(( articu+ar+# 3rom burn injurie( ma# re+ea(e e2ce((i4e ,i(tamine.T,i( increa(e( t,e roduction o3 t,e en8#me 2ant,ine o2ida(e :,ic, generate( ,#drogenero2ide and (uero2ide t:o otent 3ree radica+( t,at cau(e additiona+ ti((ue damage. T,e(eriou(ne(( o3 t,i( i( (een in t,e reort t,at t,i( +o:er( nitric o2ide in t,e b+ood reducing o2#gento t,e brain b# /! T,i( can on+# be o33(et b# a 4er# ,ig, inta"e o3 care3u++# (e+ectedantio2idant( a( recommended ,erein.

%. 5a((i4e de3icienc# o3 '*EA in t,e auti(tic( ?3actor o3 t,ree@D ditto.. S,a: recent+# reorted 1);1 ,a4e +o: c,o+e(tero+ ?$PL; C,o+e(tero+ 95C 1!G0)G0).

A recent (tud# ?Arno+d $L *#man SL 5oone# 9A Kirb# 9S. ourna+ o3 Auti(m and 'e4e+omenta+'i(order(. Augu(t !00-H --?&@6 &&;&&@ 3ound t,at % o3 c,i+dren :it, auti(m :,o con(umed aregu+ar diet ,ad at +ea(t one e((entia+ amino acid de3icienc# and t,i( grou :a( mo(t +i"e+# to bede3icient in 4a+ine +eucine ,en#+a+anine ?t,at roduce( t#ro(ine doamine and adrena+ ,ormone(@ or+#(ine. Si2t# ercent o3 c,i+dren :it, auti(m on a re(tricted diet ,ad at +ea(t one amino acid de3icienc#and t,i( grou :a( mo(t +i"e+# to be de3icient in 4a+ine i(o+eucine +eucine ,en#+a+anine or +#(ine. T,e(e:ere (+ig,t+# more +i"e+# to be de3icient in tr#to,an t,e amino acid t,at i( a nece((ar# e+ement in t,eroduction o3 (erotonin and in re4ention o3 (ubc+inica+ Pe++agra. I(o+eucine +eucine and t#ro(ine ?t,atroduce( doamine and adrena+ ,ormone(@ :ere reorted a( being t,e mo(t 3reuent+# ob(er4ed

de3iciencie(. On+# 1 o3 !& c,i+dren in t,e contro+ grou ,ad an e((entia+ amino acid de3icienc#. In anot,er(tud# re(earc,er( mea(ured +a(ma amino;acid +e4e+( o3 -/ AS' c,i+dren and 3ound t,at a++ ,ad mu+ti+ede3iciencie(. T,i( (,ou+d come a( no (urri(e but :,at i( troub+ing i( t,at 10 o3 t,e -/ c,i+dren :ere on ag+uten;3reeGca(ein;3ree ?$3GC3@ diet and t,o(e ten :ere 3ound to ,a4e t,e mo(t (e4ere de3iciencie(. T,i( i(not (urri(ing a( commercia+ intere(t( ,abit and (e+3;(e+ection ,a4e made $3GC3 into a ,ig,;carbo,#drate diet. In time increa(ing a++ergie( and (e+3;(e+ection narro: t,e diet (ti++ 3urt,er. Initia+ gain(are (ometime( +o(t and t,e c,i+d i( +itera++# (tar4ing. A c,i+d cannot t,ri4e on (uc, a diet Eit,er t,e SC'diet or 'onna $ate( Bod# Eco+og# diet i( +i"e+# a better aroac,.

Protein +a#( a critica+ ro+e in e4er# a(ect o3 ,ea+t,. Our ("in ,air and nai+( are rotein. Our immune(#(tem 3unction( +arge+# b# re+ea(ing rotein( ca++ed immunog+obu+in(H (o :it,out enoug, rotein t,e

immune (#(tem come( to a ,a+t (#(temic in3+ammation de4e+o( and t,e bod# +i4e( ?e2i(t(@ b# eating it(mu(c+e( :,ic, are rotein Brain c,emi(tr# it(e+3 i( deendent on rotein and 3att# acid( :,ic, are u(edto ma"e neurotran(mitter(. =it,out enoug, rotein t,e brain cant ma"e t,e(e neurotran(mitter( anddere((ion ,#eracti4it# or be,a4iora+ di(order( can re(u+t. T,e t,ou(and( o3 en8#me( needed 3or +i3eroce((e( are rotein(. T,ere are man# ,#(ica+ (ign( o3 rotein de3icienc# in c,i+dren. A 4er# commonone i( t,e c,aracteri(tic rotruding abdomen t,at (o man# c,i+dren :it, auti(m ,a4e. Ot,er (ign( inc+ude+o: mu(c+e tone reduced :eig,t gain or gro:t, and :ea" or (+o:;gro:ing nai+(. ou mu(t not a++o:t,e diet to be +arge+# carbo,#drate. E4er# mea+ and major (nac" mu(t ,a4e a ba+anced amount o3 roteinin ratio to carbo,#drate( Seed( and nut( are good (ource( (u+#ing about Q to 1G-t,eir content a(good ua+it# rotein. Sun3+o:er (eed ,a( ! rotein and (e(ame (eed ro4ide( good ua+it# roteinHbut not,ing can re+ace anima+ (ource(. A 4egetarian diet t#ica++# +ac"( rotein 8inc and 4itamin B1!. A+arge+# carbo,#drate diet ,a( too +itt+e rotein. T,e +i4er deend( ,ea4i+# uon adeuate amount( o3rotein or it can become cirrotic. =,en anima+( :ere rotein (tar4ed 3or on+# t:o :ee"( t,eir +i4er((,ran" &0 A gro:ing c,i+d mu(t ,a4e at +ea(t 100 gram( o3 rotein dai+#. T,i( ma# be too +itt+e 3or t,eo+der acti4e c,i+d. A gro:n man o3 1) ound( need( 1! gram( ?!& o3 a !000 ca+orie dietar#@. T,e$o4ernment (a#( #ou need on+# ,a+3 t,at

Egg( ,a4e 3rom / to 1! gram( o3 rotein deending uon t,eir (i8e. A (er4ing o3 about & o8 o3 meat ou+tr# or3i(, contain about 1/;!0 gram( o3 be(t ua+it# rotein ?bee3 i( 1;! 3at or" i( !;-) 3at c,ic"en i( 1!3at and tur"e# i( !0 3at@ a (er4ing o3 otato ro4ide( on+# ! gram( o3 rotein ?and (,ou+d be eaten on+# :it,butter or cream@. One cannot go b# t,i( tab+e o3 content ,o:e4er 3or e4en t,oug, a ,ea+t,# er(on can dige(t


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meat( and egg( at ) e33icienc# cerea+( and 3ruit( (u+# on+# % o3 t,eir roteinH 4egetab+e( %- +egume()% and nut( on+# )0. T,o(e :,o +ac" ,#droc,+oric acid :i++ not dige(t rotein t,at :e++ b# an# mean(. 5ore3rig,tening :it,out adeuate 8inc t,e amino acid( t,at are dige(ted are +arge+# e2creted in t,e urine a( :a(teand 4itamin A cannot be re+ea(ed into t,e b+ood A +ac" o3 8inc contribute( to t,e c,ronic diarr,ea o3ten (een inauti(tic(. A (u+ement o3 8inc (,o:ed a 1 reduction o3 diarr,ea.

9ecent re(earc, ,a( (,o:n t,at t,e ca(cade o3 (igna+( in t,e roin3+ammator# immune re(on(e tend to cau(e t,e

amino acid tr#to,an to brea" do:n into damaging "#nurenic acid rat,er t,an (erotonin a brain c,emica+ t,atin3+uence( mood. T,at( e2treme+# intere(tingD (a#( Fa++on becau(e (erotonin de+etion (eem( to be in4o+4ed indere((ion. So #ou can (ee a 4er# c+ear mec,ani(m :,ereb# eo+e :it, c,ronic immune acti4ation can becomedere((ed.D Su+ementing 4itamin B/ niacin and 4ariou( anti;in3+ammatorie( ma# o33(et t,i( a++o:ing tr#to,anto metabo+i8e to (erotonin. En(ure adeuate 8inc and rotein inta"e.

T,e brain i( t,e mo(t c,o+e(tero+;ric, organ o3 t,e bod#. 5#e+in i( +arge+# c,o+e(tero+. Pregnant :omen :it, +o:c,o+e(tero+ reading( are t:ice a( +i"e+# to ,a4e remature birt,( or to ,a4e babie( :it, (ma++ ,ead( ?brain(@. $reatP+ain( Laborator# reort( dangerou(+# +o: c,o+e(tero+ in 1). o3 auti(tic( (tudied. NI* conc+uded ear+ier t,ateo+e :it, tota+ (erum c,o+e(tero+ be+o: 1/0 mgGd+ ,ad a deat, rate 10;!0 ,ig,er t,an t,o(e :it, 1/0;10mgGd+. Seci3ica++# t,e# died o3 cancer ?+ung and b+adder cancer rimari+#@ re(irator# and dige(ti4e di(ea(e(uicide and trauma and ,emorr,agic (tro"e. T,e# (u33ered dere((ion an2iet# bio+ar and Par"in(on( di(ea(e andtubercu+o(i( and men :it, LL +e4e+( be+o: 1/0 mgGd+ ,ad (igni3icant+# +o:er number( o3 :,ite b+ood ce++( o3 a++t#e(. T,u( L'L rotect( again(t in3ection( and a+(o again(t dead+# to2in( (uc, a( t,at roduced b#(ta,#+ococcu(. S,a: (tud#ing auti(m and Tierne# (tud#ing t,e rare genetic conditon SLOS 3ound t,at articu+ar+#t,o(e :it, tota+ (erum c,o+e(tero+ be+o: 100 mgGd+ additiona++# di(+a#ed auti(tic (#mtom( (uc, a( (+eedi(turbance( ?+et,arg# and e2ce(( (+eeing@ inabi+it# to ta+" or :a+" anti(ocia+ tendencie( increa(ed rate( o3in3ection ("in ra(,e( (e+3;,urt3u+ be,a4ior +o:;mu(c+e tone tacti+e de3en(i4ene(( oor gro:t, rate and 4ariou(be,a4iora+ rob+em(. Lo: c,o+e(tero+ 4a+ue( are a((ociated :it, mangane(e de3iciencie( ce+iac di(ea(e,#ert,#roidi(m +i4er di(ea(e ma+ab(ortion and ma+nutrition. T,e(e condition( a++ (igni3icant+# imro4ed e4en(ome adu+t( (o"e 3or t,e 3ir(t time a++ :it,in da#( o3 ta"ing a c,o+e(tero+ (u+ement T,e +ac" o3 adeuatec,o+e(tero+ :a( 3ound to be 3rom a +ac" o3 roduction in t,e +i4er. So muc, 3or t,e dri4e to ,a4e e4er#one u(e a(tatin drug to reduce roduction b# &0 En(ure t,at #our c,i+d( tota+ (erum c,o+e(tero+ i( abo4e 1/0 mgGd+ and

t,at L'L i( 10;1/0 mgGd+ t,at i( ,i( tota+ (erum reading (,ou+d be around !00 T,i( i( be(t done :it, 3ood(?egg( and red meat@ :,ere o((ib+e but a (u+ement ma# be nece((ar# ?Ne: Beginning( Nutritiona+( SonicCholesterol@. A c,i+d :it, IgE a++erg# to egg( (,ou+d eat t,em on+# on ad4ice o3 ,i( doctor. T,e(e 3ood( ,e+ toen(ure t,at bot, rotein and c,o+e(tero+ are adeuate.

A3ter 3eeding a mi2ture o3 amino acid( to brain;damaged mice t,e rig,t ba+ance o3 brain c,emica+( :a( re(tored int,e anima+( and t,eir +earning abi+it# returned to norma+ T,e amino acid( gi4en :ere +eucine i(o+eucine and 4a+ine"no:n a( branc,ed c,ain amino acid( ?BCAA(@. BCAA( ma"e u near+# one;3i3t, o3 a++ mu(c+e rotein( anden,ance t,e biogene(i( o3 mitoc,ondria in t,e ce++( en(uring greater energ# roduction. One (tud# o3 e+der+#diabetic( (,o:ed t,at a BCAA;ric, amino acid mi2ture imro4ed numerou( arameter( o3 b+ood (ugarmetabo+i(m inc+uding ,emog+obin A1c. Anima+ (tudie( (,o: romi(e t,at ora+ BCAA( can imro4e t,ede4a(tating con(euence( o3 traumatic brain injur# b# imro4ing cogniti4e er3ormance. BCAA( ,a4e imro4edt,e (ur4i4a+ and t,e ua+i# o3 +i3e o3 t,o(e :it, +i4er cirr,o(i( ?3ree 3rom ,eatic 3ai+ure ruture o3 e(o,agea+ orga(tric 4arice( or +i4er cancer.@ T,e(e e((entia+ amino acid( are 4ita+ 3or t,e creation o3 t:o brain c,emica+( t,at+a# a "e# ro+e in t,e 3unctioning o3 ner4e(. T,e t:o neurotran(mitter( g+utamate and gamma;aminobut#ric acid?$ABA@ :or" toget,er to "ee brain acti4it# in ba+ance. $+utamate e2cite( neuron( (timu+ating t,em to 3ire:,i+e $ABA in,ibit( t,em. I3 neuron( are too e2cited or not e2cited enoug, t,e brain doe( not 3unction roer+# On+ine journa+Proceedings of the National Academy of Sciences. In 3act too muc, $ABA cau(e( +et,arg# and:i++ cau(e a di(tinct +earning di(abi+it# a( t,ere i( no retention o3 t,ing( (tudied

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Additiona++# t,ere i( ,ea4#;meta+( oi(oning6 i++ ame( 3ound t,at man# auti(tic c,i+dren are genetica++#de3icient in t,eir caacit# to roduce g+utat,ione an antio2idant generated in t,e brain t,at ,e+( remo4emercur# 3rom t,e bod#. A recent (tud# 3ound % ercent e2,ibited (e4ere+# e+e4ated CoerGMinc ?CuGMn@ratio( in b+ood (ugge(ting a di(order o3 meta++ot,ionein ?5T@ a (,ort +inear rotein re(on(ib+e 3or,omeo(ta(i( o3 coer and 8inc and man# ot,er meta+(. T,e (e4erit# o3 t,e CuGMn imba+ance :a( 3argreater t,an t,at o3 an# ot,er ou+ation :e ,a4e (tudied o4er t,e a(t ! #ear(D (aid =i++iam =a+(,P,.'. P,#(ician bioc,emi(t and c,ie3 (cienti(t o3 t,e P3ei33er Treatment Center Naer4i++e I++inoi(. *i(databa(e (ugge(t( t,at coer o4er+oad and 8inc de+etion are t,e mo(t common meta+;metabo+i(mabnorma+itie( in be,a4iora+ condition( (uc, a( A'*' auti(m dere((ion bio+ar di(order( and(c,i8o,renia. In anot,er reort o3 !- auti(tic c,i+dren :,o ,ad (erum 3erritin mea(ured 1! :ere ironde3icient. Iron de3icienc# i( a 3reuent 3actor in re(t+e(( +eg (#ndrome. A (tud# o3 iron;de3icient non;anemic rat( conc+uded /he res$lts of this st$dy sho" that L-thyroine administration and%or irons$pplementation in!reases Gl$tathione #GS&+ Gl$tathione eroidase #GS-&+ and S$per3ide ism$tase #S3& levels of erythro!ytes #red blood !ells&45Ch$ng $a 6$ 7ang 8 s$eh /saChih 199 Nov* :0#&;:'1-:.Note ,o:e4er t,e contradiction :,en u(ing (erum iron mea(urement(?(erum iron te(t( are not a( e33icient i( detecting iron de3icienc#@6 I c,ec"ed iron +e4e+( in our ou+ationo3 -000 auti(m atient(. =e 3ound t,at auti(tic c,i+dren e2,ibited ,ig,er (erum iron +e4e+( t,an contro+(?non;auti(tic ,ea+t,# c,i+dren@. *o:e4er a++ o3 t,e di33erence( occurred in about 1G- o3 t,e auti(m

ou+ation :it, t,e ot,er !G- re(emb+ing t,e contro+(. T,e ,ig,;iron "id( :ere e2treme+# ,ig, t,e re(t o3t,e auti(tic( :ere uite norma+. It aear( t,at a (egment o3 t,e auti(m ou+ation ,a( 4er# abnorma+ ironmetabo+i(m ?and abnorma+ ceru+o+a(min@DJBi++ =a+(,. So are ourD "id( ,ig, or +o: iron7 'o not re+#on (erum iron.

So (erum iron i( not t,e be(t mea(ure o3 iron (u33icienc#. B+ood te(t( 3or ,emog+obin and (erum 3erritin+e4e+( t,at are c,ec"ed 3or tran(3errin (aturation ercentage( are more u(e3u+ but t,e re(u+t( o3 t,e(e te(t(are con3ounded in (tate( o3 ro+onged in3+ammation or di(ea(e (uc, a( auti(m 3or auti(m i( a (tate o3c,ronic brain in3+ammation ?'r. 5arce+ u(t o,n *o"in(@. Tran(3errin i( a g+#corotein t,at bind( iron4er# tig,t+# but re4er(ib+#. T,e a33init# 3or Fe?III@ i( e2treme+# ,ig, but t,e a33init# decrea(e(rogre((i4e+# :it, decrea(ing * be+o: neutra+it#. A ("i++ed ,emato+ogi(t i( o3ten t,e be(t ro3e((iona+3rom :,om to obtain er(ona+ in3ormation concerning b+ood iron +e4e+(. Ferritin metabo+i(m i( in3+uencedb# t,#roid ,ormone a( :e++ a( b# iron. T,u( t,e rai(ed (erum 3erritin in ,#ert,#roid atient( ma# beartia++# attributed to increa(ed 3erritin (#nt,e(i( in t,e +i4er and it( o((ib+e +ea"age into circu+ation.=,en coer i( de3icient t,e bod# cant u(e iron (o it accumu+ate( and cau(e( damage increa(ing t,eri(" o3 T#e II diabete( b# - time(. T,ere ma# be a coer;de3icienc# anemia. T,e di(ea(e i( ca++ed(idero(i( :,ic, i( c,aracteri8ed b# a gra# a++or to t,e ("in 3rom iron accumu+ation in t,e ti((ue(. Inaddition t,e(e (u33erer( ?o3 e2ce(( (erum iron@ are unu(ua++# (en(iti4e to +ead cadmium mercur# andot,er to2ic meta+( (o t,at t,e# tend to accumu+ate rat,er t,an e+iminate t,em. T,i( i( robab+# becau(eP,a(e I :a( o4eracti4e comared to P,a(e II in %/. P,a(e I :a( 3unctiona+ but P,a(e II :a( imairedin 1& t,u( 100 o3 c,i+dren :it, auti(m ,ad abnorma+ +i4er deto2i3icationJ S. Ede+(on and '. CantorTo2ico+og# and Indu(tria+ *ea+t, ?!000@ 1/ 1;. C,i+dren are more (u(cetib+e t,an adu+t(. T,e# ,a4emore e2o(ure ?cra:+ing +a#ing in dirt +ic"ing ,and(@ and t,e# e2crete +e(( ?adu+t( retain on+# 1

c,i+dren retain --@. Iron inter3ere( :it, t,e ab(ortion o3 t,e e((entia+ minera+( 8inc mangane(e andmo+#bdenum and it de(tro#( 4itamin E. It( o:n ab(ortion i( b+oc"ed b# ca+cium and magne(ium.Additiona++# :,en a minera+ i( +ac"ing it( ,ea4# meta+ eui4a+ent tend( to be ,e+d and u(ed 3or e2am+e6cadmium (it( ju(t beneat, 8inc in t,e eriodic tab+e o3 t,e e+ement( (o t,eir (tructure( are (imi+ar.Cadmium can re+ace 8inc in t,e ti((ue( and in en8#me binding (ite(. An imortant cau(e o3 cadmiumto2icit# ot,er t,an e2o(ure i( a 8inc de3icienc#. I3 8inc i( de3icient due to oor diet or (tre(( t,e bod#:i++ ab(orb cadmium 3rom 3ood :ater or t,e air and u(e it in +ace o3 8inc. Our greate(t e2o(ure tocadmium i( :,ite 3+our

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Ne4ert,e+e(( i3 a mou(e cannot ma"e 5T t,en it (,ou+d not get coer de3icient :,en 3ed a ,ig,;8incdiet. =e 3ed (ome o3 t,e(e mice and (ome contro+ mice ?one( t,at can ma"e 5T@ diet( t,at containednorma+ amount( o3 8inc and (ome t,at contained muc, more 8inc. T,e re(u+t( (,o:ed t,at t,e mou(e:it,out 5T got coer de3icient :,en 3ed t,e (ame ,ig,;8inc diet a( t,e mou(e t,at ,ad 5T. T,i( (tud#(trong+# (ugge(t( t,at t,e o+d t,eor# i( not true and t,at (timu+ation o3 5T i( not nece((ar# 3or ,ig,;8incto bring about a coer de3icienc#. =e (ugge(t in(tead t,at t,e ,ig, 8inc i( in,ibiting a coer tran(ortrotein in t,e inte(tina+ membrane and coer cannot be ab(orbedDJ9ee4e( P$ Coer 5etabo+i(m in5eta++ot,ionein;nu++ 5ice Fed a *ig,;8inc 'iet. Nutr Bioc,em 6%;/01 1%. Coer i(re3erentia++# bound to tran(3errin t,e rotein tran(ort mo+ecu+e in t,e muco(a cometing :it, iron.Norma++# t,i( tran(ort mec,ani(m i( not com+ete+# (aturated (o t,ere are adeuate binding (ite( 3orbot, t,e iron and t,e coer. Ne4ert,e+e(( :,en coer i( admini(tered in e2ce(( iron ab(ortion i(in,ibited becau(e o3 t,e re3erentia+ binding o3 coer to t,e tran(3errin. Su+ement coer and 8inc andcoer and iron at di33erent time( o3 da#. =,en (erum iron i( ,ig, (u+ement tran(3errin ?+acto3errin@ tobind t,e iron and tran(ort it (a3e+#. Co+o(trum i( a good (ource o3 +acto3errin.

Tran(3errin i( a b+ood rotein t,at carrie( iron t,roug, t,e b+ood to t,e bone marro: (+een and +i4er 3oreit,er t,e (torage o3 iron a( 3erritin or t,e manu3acture o3 ne: red b+ood ce++(. It i( a rotein :it, a re+ati4e+#(,ort ,a+3;+i3e t,at can be a mar"er 3or recent rotein (tatu( and it i( u(ed 3or t,i( uro(e. Lo: b+ood

tran(3errin ma# be an indicator o3 rotein or ca+orie ma+nutrition re(u+ting in inadeuate (#nt,e(i( o3tran(3errin b# t,e +i4er or it can re(u+t 3rom e2ce(( rotein +o(( t,roug, t,e "idne#( ?roteinuria@. A (#(temicin3ection or cancer can a+(o +o:er t,e b+ood tran(3errin +e4e+. A ,ig, b+ood tran(3errin i( a mar"er o3 ironde3icienc#. I3 an indi4idua+ ,a( a +o: b+ood tran(3errin +e4e+ t,e roduction o3 ,emog+obin can be imaired andcan +ead to anemia e4en i3 t,ere i( am+e iron in t,e bod#.

Ceru+o+a(min i( a coer;containing rotein in4o+4ed in ,anding o4er iron 3rom tran(3errin to,emog+obin in t,e 3ormation o3 ne: red b+ood ce++( or in remo4ing iron 3rom o+d red b+ood ce++( 3orinc+u(ion in ne: one(. A coer de3icienc# re(u+t( in +o: ceru+o+a(min and can re(u+t in anemia t,atre(ent( muc, +i"e iron;de3icienc# ?microc#tic ,#oc,romic@ anemia o((ib+# +eading to a mi(diagno(i(.A ceru+o+a(min de3icienc# i( a((ociated :it, iron accumu+ation in t,e ancrea( +i4er and brain re(u+ting

in neuro+ogica+ di(order(. Laborator# te(ting 3or iron o4er+oadG,emoc,romato(i( begin( :it, t:o (eci3icb+ood te(t( Serum Iron and TIBC ?tota+ iron binding caacit#@ 3rom :,ic, t,e Serum Tran(3errinSaturation i( ca+cu+ated. Serum Ferritin i( 3reuent+# mea(ured a( :e++ i3 o((ib+e :,i+e 3a(ting toe4a+uate t,e bod#( iron (tore( and e(timate t,e degree o3 iron o4er+oad.

B+ood and urine ana+#(e( #ie+ded e4idence o3 a meta++ot,ionein d#(3unction in & o3 0- atient( ?@ diagno(ed:it, auti(m (ectrum di(order( according to =a+(, (ugge(ting t,at auti(m ma# be cau(ed b# eit,er a genetic 5Tde3ect or a bioc,emica+ abnorma+it# :,ic, di(ab+e( 5T rotein. 5ec,ani(m( :it, t,e otentia+ 3or di(ruting 5T3unctioning inc+ude (e4ere Mn de+etion o((ib+# 3rom a #rro+e di(order imaired (#nt,e(i( o3 $S* to2ic meta+o4er+oad and a (u+3ur amino acid abnorma+it#. An 5T di(order ma# a33ect t,e de4e+oment o3 brain neuron( andma# cau(e imairment( in t,e immune (#(tem and ga(trointe(tina+ tract a+ong :it, ,#er(en(iti4it# to to2ic meta+(D,e (aid. T,e e2ce(( coer in t,e(e "id( i( robab+# 3rom t:o cau(e(. 5ercur# dere((e( 8inc and t,ere i( a ,ig,

incidence o3 8inc ma+ab(ortion. To reduce coer #ou mu(t u(e (igni3icant amount( o3 4itamin C and 8inc.Ne4ert,e+e(( t,e (+o:er t,e metabo+i(m o3 an indi4idua+ t,e more +i"e+# ,e i( to de4e+o coer o4er+oad regard+e((o3 ,i( coer inta"e according to 'a4id L. =att( '.C. P,.'. director o3 re(earc, at Trace E+ement( Inc. in 'a++a(Te2a( and aut,or o3 Trace E+ement( and Ot,er E((entia+ Nutrient( ?Trace E+ement( 1@.

Treatment 3or t,i( imba+ance bet:een 8inc and coer center( on (timu+ation o3 5T rotein :it, di4a+entmeta+( ?(uc, a( 8inc and mangane(e@ t,at are in de+etion and b# ro4iding N;acet#+c#(teine (erine(e+enium and ot,er con(tituent( o3 5T. O3 (econdar# bene3it are 4itamin( B/ A C ' E g+utat,ioneand g+ucocorticoid( ?anti;in3+ammator# drug(@. T,i( treatment (,ou+d be gradua+ during t,e 3ir(t & :ee"(o3 treatment to a4oid raid re+ea(e o3 coer 3rom ti((ue( :,ic, cou+d cau(e a (udden :or(ening o3

%


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(#mtom(. 5T;Promotion mu(t be done 4er# care3u++# to a4oid 8inc de+etion t,at can re(u+t intemorar# :or(ening o3 be,a4ior (timming enure(i( etc. Se4ere 8inc de3icienc# ,a( e33ect( on t,edi(tribution o3 nine e+ement( ?ota((ium ,o(,oru( (odium magne(ium ca+cium iron 8inc coerand mangane(e@ in region( o3 t,e rat brainD Nutr 11-?10@61%;0 ?1%-@R.

Sea"ing o3 Fibrom#a+gia 'r. Brice E.


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C,ronic ancreatiti( a+t,oug, re+ati4e+# rare in t,e =e(tern =or+d i( common in certain troica+ 8one(:,ere (ta+e cro( (uc, a( ca((a4a are ric, in c#anogenic g+#co(ide(. T,i( aer re4ie:( t,e e4idence 3ora c#anide connection :it, re3erence to e2erimenta+ (tudie( u(ing anot,er +ant nitri+e crambeneH andt,en e2amine( t,e ,#ot,e(i( t,at !hroni! pan!reatitis represents a manifestation of $n!oordinateddetoifi!ation rea!tions bet"een hase 8+ pan!reati! !yto!hrome


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a( a ,#drogen tran(ort in ce++u+ar re(iration. It 3unction( a( a de,#drator and diuretic. It i( t,e KE togood ,ea+t,. =atc, 3or t,e (ign( t,at re4ea+ re;e2i(ting c,ronic 4itamin C de3iciencie(. S,a: ?1& @(tate( t,at 3ood deo(it( on our teet, and denta+ tartar rere(ent( t,i( condition. ?I mig,t add an# (ign( o3#rro,ea andGor no(eb+eed (,ou+d be a red 3+ag.@ Peo+e :,o 3ind t,at t,e# are counted in t,i( grou(,ou+d (u+ement t,eir diet :it, at +ea(t t:o gram( o3 4itamin C ?a( Sodium A(corbate@ eac, da# ; 'rFred 9. K+enner 5'.

$+utat,ione con(umtion 3rom 3ood( range( 3rom !;1! mi++igram( er da#. =it, t,e ro4i(ion o3(u33icient amount( o3 (u+3ur t,e +i4er :i++ roduce 3ar more g+utat,ione ?u to 1&000 mi++igram( er da#@t,an :,at t,e diet ro4ide(. Su+3ur;ric, 3ood( ?gar+ic egg( a(aragu( onion(@ ma# be +ac"ing in 4ariou(diet( and t,e ro4i(ion o3 (u+3ur in 3ood (u+ement( ?(u+3ur;bearing amino acid( +i"e N;acet#+c#(teinetaurine 5S5 and +ioic acid@ or g+utat,ione it(e+3 ma# be ad4antageou(.

Glyconutrients have proven to enhance glutathione, glutathione peroxidase, and superoxide dismutaseSugars that

Heal, by Emil I. Mondoa, MD, Page 191. The Mannose found in Ambrotosesignificantly inhibits superoxide anion

formation, thus reducing hydrogen peroxide formation Kim HS, et al, 8/99. Ambrotose AOby Mannatech

combines vital glyconutrients with needed antioxidants and precursors that form glutathione nicely addressing this

lack. Additionally, vitamin D reduces inflammatory cytokines and increases concentrations of glutathione - the brains

master antioxidant. N-acetylcysteine (NAC) can raise abnormally low GSH levels also. Van Zandwijk found that adaily dose of 600 mg NAC was beneficial and innocuous while 1200 mg and 1800 mg per day caused significant

adverse effects, possibly by contributing to cysteine toxicity and to its chelating heavy metals (moving mercury).

Cysteine catabolism produces two sets of products: pyruvate + sulfate + ammonia and taurine + CO2. One of

cysteines breakdown enzymes, cysteine dioxygenase (CDO), needed to form these metabolites has been

demonstrated to be low in children with autism. This tends to an excess of cysteine that can reach toxic levels, and

possibly to a lack of CO2. Excess free cysteine has been implicated in several degenerative diseases including

Rheumatoid Arthritis, Alzheimers Disease, Autism (neurodevelopmental), Parkinsons Disease, Peripheral Neuron

Degeneration, and others. This requires some caution in using NAC and GSH (transdermally). Note that cysteine

dioxygenase is a non-heme iron enzymethat catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine

sulfinate) by incorporation of dioxygen. Supplement serine and vitamin B6, magnesium, zinc, selenium, molybdenum,

and iron (if needed) to support this pathway. The amino acid glycine readily converts to serine and supports glutathioneproduction.

5eta++ot,ionein( acro(( (ecie( are ric, in c#(teine ?V-0@ and ,a4e ,ig,er a33initie( 3or mercur# ?*g@ andcadmium ?Cd@ t,an 3or 8inc. T,ere3ore a( *g and Cd bind to meta++ot,ionein and are re(tricted 3rom entering t,emitoc,ondria 8inc i( re+ea(ed. T,e 3ree ioni8ed 8inc :,ic, :ou+d be to2ic i3 ermitted to accumu+ate bind( to ameta+ regu+ator# e+ement on t,e romoter region o3 t,e meta++ot,ionein gene and turn( onD t,e (#nt,e(i( o3meta++ot,ionein. Increa(e( o3 a( muc, a( -;time( are reorted. Suc, induction o3 meta++ot,ionein ro4ide( increa(edbinding caacit# 3or bot, to2ic meta+( ?rotecti4e@ and 8inc ?3unctiona+@. T,e di(+acement o3 8inc in t,e re(enceo3 to2ic meta+ burden ma# e2+ain in art :,# increa(ed +e4e+( o3 8inc are (o common+# (een in t,e (ca+ ,air o3atient( e2,ibiting (igni3icant +e4e+( o3 to2ic meta+( *g Cd Pb ?Wuig unub+i(,ed ob(er4ation(@. 5o(t o3 t,e 8inc

i( ce++u+ar :it, on+# a (ma++ amount in t,e b+ood +a(ma. For t,i( rea(on b+ood te(t( are a oor indicator o3(#(temic 8inc (tatu(.

9etro(ecti4e ana+#(i( o3 t,e 3u++;b+ood count and a( 3ar a( :a( a4ai+ab+e (erum;3erritin mea(urement( o3 / c,i+dren?! :it, auti(m and && :it, A(erger( (#ndrome@ :a( underta"en. Si2 o3 t,e auti(tic grou ?11.&@ :a( (,o:n to,a4e iron de3icienc# anemia and o3 t,e !- auti(tic c,i+dren :,o ,ad (erum 3erritin mea(ured 1! ?!.1)@ :ere ironde3icient. On+# t:o o3 t,e A(erger( grou ?&.@ ,ad iron de3icienc# anemia and o3 t,e !- c,i+dren :,o ,ad t,eir(erum 3erritin mea(ured on+# t,ree ?1-./&@ (,o:ed iron de3icienc# anemia. Iron de3icienc# :it, or :it,out anemiacan imair cognition and i( a((ociated :it, oor mu(c+e (trengt, and :it, de4e+omenta+ (+o:ing in in3ant( and moodc,ange( and oor concentration in c,i+dren.

11


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Furt,ermore auti(tic( minera+( 3att# acid( and amino acid( are de3icient andGor imba+anced. T,eir roduction o3 redand :,ite b+ood ce++( i( irregu+ar. T,e# ,a4e a d#(3unctiona+ immune (#(tem ?o3ten attac"ing (e+3D@. T,e# 3reuent (,o:a ,ig, :,ite;b+ood;ce++ count indicating in3+ammation ?no: (een a( a (tro"e redictorJc,ronic +o:;+e4e+ in3+ammationincrea(e( ri(" o3 ,eart di(ea(e b# and ri(" o3 (tro"e b# & in o(tmenoau(a+ :omen@ t,at :i++ uic"+# norma+i8e :,enadeuate anti;in3+ammator# en8#me( are ro4ided. ?I recommend or =oben8#m NT53rom #our ,ea+t, 3ood(tore. At t,e 4er# +ea(t gi4e brome+ain in (igni3icant amount(. Ne4ert,e+e(( remember t,at (ome :,o ta"e brome+ainget diarr,ea and (ome are a++ergic to it. 'r. Car+o( Pardo;


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ma+ab(ortion o3 (e+enium. o not give seleni$m "ith a!id =$i!es, Furt,er a (tud# o3 c,i+dren in Maire3ound t,at in ,#ot,#roidi(m induced b# iodine de3icienc# (u+ementing a( +itt+e a( 0 mcgGda# (e+eniumcau(ed increa(ed ,#ot,#roid condition( +o:ering T& rai(ing TS* ?robab+# due to increa(edcon4er(ion o3 T& to T- a good t,ing@. 'o not (u+ement (e+enium :,en iodine i( de3icient or betterdo (u+ement iodine (igni3icant+# :,en (u+ementing (e+enium. Additiona++# #ou mu(t (u+ementiodine and antio2idant( 4itamin( C and E and (e+enium :,en (u+ementing t,e 3att# acid( or #ou :i++de+ete t,e(e 4ita+ nutrient( and (u33er 3ree;radica+ damage.

9e(u+t( obtained 3o++o:ing iodine (u+ementation re4ea+ed t,at in some s$b=e!ts+ the $rine levels ofmer!$ry+ lead+ and !admi$m in!reased by several fold after =$st one day of s$pplementation, Fora+uminum t,i( increa(ed e2cretion :a( not ob(er4ed u(ua++# unti+ a3ter one mont, or more on t,e iodine(u+ement. Additiona++# iodine (u+ementation re(u+ted in mar"ed increa(e in bromide e2cretion and toa +e((er e2tent in 3+uoride a+(o. Iodine ma# cau(e ga(triti( and re3+u2 b# di(engaging t,e bromine 3ound incommercia+ bread in articu+ar in t,e gut and it i( re+ie4ed b# c,+oro,#++. Lac" o3 iodine and 8inccontribute to +ac" o3 (tomac, acid roduction. T,e(e 3inding( ,a4e (ince been re+icated in a +argenumber o3 te(t(. Fema+e atient( :it, brea(t cancer (eem to retain more iodine on t,e +oading te(t t,ennorma+ (ubject( and e2creted more bromide t,an norma+ (ubject(.

T,e 3orm o3 B/ (u+emented ma# be imortant a( it :a( 3ound t,at t,e amount o3 acti4ated B/?#rido2a+;;,o(,ate@ :a( +o: in &! o3 auti(tic(. T,e(e de3iciencie( comromi(e immune 3unctionand ro4ide inadeuate antio2idant rotection to o33(et t,e ,ig, o2idati4e (tre(( t,e(e c,i+dren (u33ert,u( cau(ing (igni3icant damage to ce++( t,roug,out t,e bod# and brain.

T,e mec,ani(m o3 (tre(( uon t,e bod# :a( ju(t reorted in t,e 5a# !00% i((ue o3 Brain Be,a4ior andImmunit#. Te+omere( are ca( at t,e end( o3 c,romo(ome( t,at contribute to t,eir (tabi+it#. Eac, time ace++ di4ide( te+omere( +o(e +engt,H and t,u( a ce++( +i3e i( determined. Abnorma++# (,ortened te+omere( in:,ite b+ood ce++( "no:n a( +#m,oc#te( ,a4e been a((ociated :it, *I


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1%&! and !00- and 3ound an 11 ercent dec+ine in iron content a 1/ ercent dec+ine in coer a ! ercentdec+ine in 8inc and a 0 ercent dec+ine in (e+enium T,i( 3act ma"e( u(e o3 a good mu+ti4itaminGminera+(u+ement 4ita+ to ,ea+t, :e++;being and +engt, o3 +i3e e(ecia++# in toda#( (tre((ed out :or+d. One (tud#con3irmed t,i(. O4er a ten #ear eriod on+# ,a+3 a( man# :,o too" a mu+ti4itaminGminera+ (u+ement died

5ot,er( are under a( muc, or more (tre(( t,an t,eir c,i+dren and need to dea+ :it, it a( out+ined ,erein. Studie( (,o:t,at 4itamin C at 100;-000 mg da# reduced a++ mar"er( o3 (tre(( in bot, marat,oner( and :or";(tre((ed (ubject(

inc+uding +o:er corti(o+ +e4e+(. Sti++ ot,er (tudie( (,o:ed t,at bot, omega;- 3i(, oi+ and P,o(,atid#+(erine(igni3icant+# b+unted t,e ri(e in corti(o+ +e4e+( and +o:ered ot,er mar"er( o3 (tre(( re(u+ting in reduction o3 angeraggre((ion and dere((ion. C,romium ?!00 mg da#@ reduce( corti(o+ +e4e+( b# &) a( doe( a &;minute ma((age?bac"rub7@. Ta"e a ,ot E(om (a+t( bat,. 9,odio+a 9o(ea an adatogenic ,erb re4ent( adrena+ burnout t,at o3tenoccur( 3rom +ong;continued c,ronic (tre((. Fina++# moderate dai+# e2erci(e +o:er( (tre((;induced ,ormone +e4e+(en,ance( immune 3unction boo(t( circu+ation to t,e brain imro4e( ua+it# o3 (+ee and aid( in :eig,t;contro+. Arecent (tud# (,o:ed t,at t,e te+omere( t,at determine :,en a ce++ can no +onger reroduce it(e+3 and mu(t die :ere(,ortened b# o2idati4e (tre(( decrea(ing b# at +ea(t 10 #ear( one( +i3e e2ectanc# Anot,er (tud# (,o:ed t,at t,o(e:,o :ere otimi(tic ,ad a +o:er ri(" o3 deat, 3rom a++ cau(e( and a !- +o:er ri(" o3 cardio4a(cu+ar deat,Anot,er (tud# 3ound t,at t,o(e under con(tant re((ure :ere u to !;1G! time( more +i"e+# to (u33er a ,eart attac"t,an t,o(e :it, re+ati4e+# (tre((;3ree +i4e(. 5om u(e t,e(e (u+ement( "ee a ,oe3u+ e2ectant out+oo". Socia+i8e

+aug, a +ot ta"e a :a+" and ta"e care o3 #our(e+3 3ir(t our 3ami+# need( #ou 3or t,e 3u++ cour(e.Anot,er (tud# i( reorted6 Abou 'onia o3 'u"e Xni4er(it# in a decade o3 neuro+ogic re(earc, ,a( re4ea+ed:ide(read damage to t,e brain ner4ou( (#(tem +i4er and te(te( o3 rat( e2o(ed to /0 da#( o3 +o:;do(ec,emica+( ;; t,e in(ect ree++ant 'EET t,e in(ecticide ermet,rin and t,e anti;ner4e ga( agent #rido(tigminebromide. T,e(e are t,e drug( gi4en (o+dier( during t,e Per(ian $u+3 =ar and t,e rat( :ere e2o(ed to t,e (ame+e4e+( ;; in :eig,t;adju(ted do(e( ;; a( t,e (o+dier( :ere reorted+# gi4en. 'EET a+one cau(ed a decrea(e inBBB ermeabi+it# in t,e brain(tem. A combination o3 'EET and ermet,rin (igni3icant+# decrea(ed t,e BBBermeabi+it# in t,e corte2. A++ treatment( cau(ed a (igni3icant dec+ine in (en(orimotor er3ormance in a do(e;andtime;deendent manner. T,e(e re(u+t( (,o: t,at dai+# derma+ e2o(ure to 'EET a+one or in combination :it,ermet,rin decrea(ed BBB ermeabi+it# in certain brain region( and imaired (en(orimotor er3ormance. 'onot u(e 'EET on c,i+dren.

No: Abou 'onia ,a( demon(trated t,at t,e combination o3 (tre(( and (,ort;term e2o(ure to c,emica+( ?!% da#(@can romote ce++u+ar deat, in (eci3ic brain region( and (eriou( injur# to t,e +i4er. Brain region( t,at (u(tained(igni3icant damage in t,i( (tud# :ere t,e cerebra+ corte2 ?motor and (en(or# 3unction@ t,e ,iocamu( ?+earningand memor#@ and t,e cerebe++um ?gait and coordination o3 mo4ement(@. *i( ear+ier (tudie( demon(trated (e4eredamage to t,e cingu+ate corte2 dentate g#ru( t,a+amu( and ,#ot,a+amu(.

Stre(( a+one cau(ed +itt+e or no brain injur# in t,e rat( nor did t,e t,ree c,emica+( gi4en toget,er in +o: do(e( 3or!% da#(. But :,en :e ut t,e anima+( under moderate (tre(( b# (im+# re(tricting t,eir mo4ement in a +a(tic,o+der 3or 3i4e minute( at a time e4er# da# t,e anima+( e2erienced enoug, (tre(( t,at it inten(i3ied t,e e33ect( o3t,e c,emica+( dramatica++#.D T,e (tud# (,o:ed t,at (tre(( +u( c,emica+( increa(ed t,e amount o3 de(tructi4emo+ecu+e( in t,e brain ca++ed reacti4e o2#gen (ecie( ;; a+(o "no:n a( o2#gen 3ree radica+(. T,i( a(toni(,ing (tud#(,o:( again t,e ab(o+ute nece((it# o3 maintaining ,ig, +e4e+( o3 a 4ariet# o3 antio2idant( b# a++ :,o 4a+ue t,eir,ea+t, and :e++ being in toda#( to2ic (tre((;3i++ed :or+d

An e2+anation o3 t,e :,# o3 (ome o3 t,e(e t,ing( i( (ugge(ted in te(t( on mice. Since t,e immune (#(temde4e+o( during ge(tation materna+ 8inc deri4ation ,a( been (tudied in mice. T,e re(u+t( (,o:ed t,att,e o33(ring born to 8inc;de3icient dam( ,ad a great+# reduced immunocometence t,e +#m,oid organ(being articu+ar+# a33ected. Anot,er (tud# b# t,e (ame aut,or( 3ound t,at t,i( dimini(,edimmunocometence can er(i(t 3or a( +ong a( t,ree generation( o3 norma++# 3ed o33(ring T,e rob+em i(in,erited but not genetic Furt,er (tudie( (,o:ed t,at i3 t,e o33(ring :ere on+# moderate+# deri4ed o3

1&


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8inc during t,e +atter t:o;t,ird( o3 regnanc# e4en t,i( can +ead to +ong;+a(ting aberrant attern( o3(erum Immunog+obu+in(;$ ?Ig$@ and Immunog+obu+in;A ?IgA@ +e4e+( de(ite a com+ete nutritiona+re,abi+itation beginning at birt,. T,i( (eem( di(couraging o3 reco4er# but t,e o((ibi+it# o3 reco4er# i( int,eraeutic amount( o3 4itamin B/and 8inc. Additiona++# t,e o:er3u+ antio2idant 3ormu+a Ambroto(eAO> :i++ great+# en,ance t,at o((ibi+it#. Since muc, o3 t,e rob+em i( 3rom to2in(D 3rom Candida orot,er gut at,ogen( and en4ironmenta+ oi(on( it i( ,e+3u+ to "no: t,at 4itamin B1! great+# +ac"ing in t,eAmerican diet i( o:er3u+ in decomo(ing a++ to2in(. Sub+ingua+ 5et,#+coba+amin ?Source Natura+(@ or B1!injection( are 4er# bene3icia+. 5an# 'AN doctor( are u(ing B1!injection( :it, good re(u+t(.

*a4ing read t,e abo4e one ma# get t,e imre((ion t,at a++ i( :e++ :it, 5om and 'ad. Not (o T,oug, a recent(tud# reort( t,at auti(tic atient( are in 3act c,aracteri8ed b# re(enting in t,eir b+ood ,ig, +e4e+( o3 non;in,erited antibodie( again(t t,e bod#( o:n brain ti((ue and con3irmed t,at t,e(e antibodie( :ere not re(ent int,eir arent( t,e(e are (ti++ in,erited c,aracteri(tic(. Studie( (,o: tremendou( +ac" in t,e American ub+ic. 5enand :omen (,o: t,e(e de3iciencie( in a(toni(,ing+# ,ig, number(6


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POTTEN$E9 CAT EPE9I5ENT SX55A9

G?3@ A C B

733 7B ?a" meat ?a" mil aste$ri>ed mil Bvaporated mil Condensed mil

1st Generation?emainedhealthy

?emainedhealthy

eveloped diseases and illnesses near end of life

2nd Generation ?emainedhealthy ?emainedhealthy eveloped diseases and illnesses in middle of life

:rd Generation?emainedhealthy

?emainedhealthy

eveloped diseases and illnesses in beginning of life* many diedbefore si months of age*

yme-less+n$trient-poor diet.T,e (tud# ro4ed t,at eigenetic :ea"ne(( become( more e4ident :it, eac, generation butmore imortant+# t,at t,ere come( a oint :,en it become( tota++# out o3 contro+. T,i( i( e4ident in t,e 3ourt,generation. 8t too another three generations for third-generation !ats pla!ed on a ra"-food diet at birth toret$rn to base-line health of the first generation, Con3irming t,i( a (tud# o3 4er# o+d ,uman( (,o:ed t,at t,eir+i3e(t#+e ,ad more to do :it, t,eir ad4anced age t,an did t,e age attained b# t,eir arent(. Ne4ert,e+e(( arent(mu(t ta"e care o3 t,eir ,ea+t, need( be3ore concei4ing a c,i+d T,o(e concerned ma# reue(t m# aerPrearation 3or a *ea+t,# *a# C,i+dD.

One (tud# 3ound t,at rob+em 3ood( in t,e diet accounted 3or !& o3 t,e (#mtom( in c,i+dren "ho "erealready gl$ten-free and !asein-free*,o:e4er rob+em 3ood( in t,e diet accounted 3or -& o3 t,e(#mtom( in c,i+dren :,o :ere not re4iou(+# g+uten;3ree and ca(ein;3ree. A+t,oug, t,ere i( great4ariation among c,i+dren in mo(t c,i+dren :e 3ound aro2imate+# one;t,ird o3 t,e (#mtom( :ere 3oodre+ated and t:o t,ird( o3 t,e (#mtom( :ere re+ated to t,e en4ironmenta+ 3actor(6 4o+ati+e organic(+a(tic( re(in( and mo+d(. In term( o3 t,e t#e( o3 (#mtom( t,ere :a( great 4ariationH ,o:e4er mo(tc,i+dren re(onded a( 3o++o:(6 P,#(ica+ (#mtom( (uc, a( conge(tion ec8ema and a(t,ma :ere eua++#

cau(ed b# 3ood and en4ironmenta+ 3actor(. S#mtom( a((ociated :it, t,e dige(ti4e (#(tem :erea((ociated :it, 3ood( t:o;t,ird( o3 t,e time and a((ociated :it, en4ironmenta+ 3actor( one;t,ird o3 t,etime. Ne$rologi!al symptoms "ere asso!iated "ith environmental fa!tors F


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+ioic acid@ (ca4enge( ero2#nitrite ?a dangerou( 3ree radica+ t,at contribute( to in3+ammator# roce((e( and ,ardeningo3 t,e arterie(JC,en !00!@H and t,u( in,ibit( CNS in3+ammation b+ood;CNS barrier ermeabi+it# c,ange( and ti((uedamage in a mou(e mode+ o3 mu+ti+e (c+ero(i(JFASEB !000 ArH 1&?@6/1;%. 5an# o3 t,e(e c,i+dren ,a4e +o:ureaGuric acid o((ib+# re3+ecting ,ig, o2idati4e (tre((. Stre(( a+(o cau(e( t,e bod# to u(e 8inc and magne(ium and t,ere(u+ting +ac" o3 magne(ium can cau(e dere((ion an2iet# (en(iti4itie( to +ig,t (ound( temerature and touc, and to,eart rob+em( articu+ar+# a raid beat and arr,#t,mia(. T,i( ma# not be 3rom +ac" o3 inta"e but due to e2ce((i4ega(trointe(tina+ +o((e( 3rom ma+ab(ortion ?ta"e magne(ium taurate to great+# en,ance ab(ortion and to reduce t,e+a2ati4e e33ect o3 unab(orbed magne(ium@ diarr,ea bo:e+ re(ection or rena+ +o((e( due to ,#erca+cemia a+co,o+e2ce(( or u(e o3 diuretic( c,emot,era# or antibiotic(. It occur( a+(o a( a metabo+ic derangement o3 bot, t,#roid andarat,#roid di(order(. T,e +o:er +e4e+( o3 magne(ium :it,in t,e ce++ not on+# doub+e( t,e generation o3 3ree radica+( butgreat+# +o:er( g+utat,ione ?a( doe( a +ac" o3 4itamin '@ re(u+ting in &0 to 0 more damage T,e nutrient de3iciencie(can occa(iona++# cau(e e2treme be,a4ior(H (ome c,i+dren :it, auti(m ,a4e been reorted to ,a4e actua++# gouged outt,eir e#e( due to a ca+cium de3icit. I3 #our c,i+d i( u(,ing at ,i( e#e( (u+ement ca+cium magne(ium and 4itamin '-and get ,im in t,e (un. Ne4ert,e+e(( re(earc,er( too" ("in bio(ie( o3 1! c,i+dren :it, burn injurie( and trac"ed t,eir4itamin ' +e4e+( 3or (e4en #ear(. T,e# 3ound t,at t,e c,i+dren( ("in ?e4en unburned ("in@ became (o ine33icient atgenerating 4itamin ' t,at e2o(ure to (un+ig,t a+one doe( not roduce enoug, o3 t,e 4itamin

*#eracu(i( :,ic, i( de3ined a( abnorma+ acutene(( o3 ,earing due to increa(ed irritabi+it# o3 t,e (en(or# neura+

mec,ani(mH i( c,aracteri8ed b# into+erance 3or ordinar# (ound +e4e+(. Xn+i"e ,#er(en(iti4it# to +o:;itc,ed ,um( t,i( i(,#er(en(iti4it# to a++ (ound( ma"ing da#;to;da# +i3e a mi(er#. One reort +in"( &0 o3 auti(m ca(e( :it, *#eracu(i(

C,i+dren :it, auti(m ,a4e a +ot o3 metabo+ic abnorma+itie( a( indicated but t,at i( a re(u+t o3 t,e rob+em( :it,t,eir immune (#(tem. *ea4# meta+( (uc, a( mercur# ?*g@ induce a dramatic acti4ation o3 t,e immune (#(temand autoantibod# roduction in t,e genetica++# (u(cetib+e. T,i( autoimmune (#ndrome i( deendent on T;Ce++(:,ic, are imortant 3or B;Ce++ acti4ation and c#to"ine (ecretion. Studie( ,a4e 3ound mercur# imair( t,e bod#(abi+it# to "i++ Candida a+bican( b# imairment o3 t,e +#tic acti4it# o3 neutro,i+(. P+ant :or"er( :it, a4eragemercur# e2cretion o3 !0;ugGg creatinine :ere 3ound to ,a4e +ong;+a(ting imairment o3 neutro,i+ 3unction.Candidia(i(Gd#(bio(i( a((ociated :it, *g burden can comromi(e t,e ab(ortion o3 aromatic amino acid( (uc,a( ,en#+a+anineGt#ro(ine and tr#to,an :,ic, are recur(or( to doamine eine,rine and noreine,rineand (erotonin re(ecti4e+#D T,e ro;o2idati4e e33ect( o3 t,e meta+( are comounded b# t,e 3act t,at t,e meta+(a+(o in,ibit antio2idati4e en8#me( and de+ete intrace++u+ar g+utat,ione.D ?Wuig unub+i(,ed@. T,i( can +ead toman# i3 not a++ t,eir ,ea+t, and be,a4ior rob+em( and i( a major rea(on to en(ure a ,ig, inta"e o3 rotecti4eantio2idant( (uc, a( Ambroto(e AO> ?5annatec, Inc.@ (e+enium a+,a +ioic acid and 4itamin( C and E.

A +i"e+# cau(e o3 t,i( ,oarding o3 ,ea4# meta+( b# t,e auti(tic c,i+d i( (et 3ort, and t:o e33ecti4e :a#( too4ercome autoimmunit# are (ugge(ted6


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roer+# and t,u( unab+e to remo4e ,ea4# meta+( t,e# ma# be damaged b# ,ea4# meta+ +oad(norma+ c,i+dren ea(i+# e2crete. YTa"e note t,at t,e u(ua+ 4itamin ' (u+ement ?ergoca+ci3ero+@ ,a(otenc# o3 about one;uarter t,at o3 (un;generated 4itamin '-?c,[email protected]

Sei8ure( are 4er# common in auti(m and acti4ated 4itamin ' reduce( t,e (ei8ure t,re(,o+db# ma"ing brain ti((ue +e(( +i"e+# to (ei8e. A contro++ed (tud# 3ound 4itamin ' reduced t,eincidence o3 (ei8ure( in atient( :it, intractab+e (ei8ure( ?a( doe( magne(ium (u+3ate ;E(om (a+t( ; a( a bat, or medica++# in3u(edGinjected@.

Pro3e((or( *o++i( and =agner o3 t,e 5edica+ Xni4er(it# o3 Sout, Caro+ina di(co4ered t,atbrea(t mi+" i( a (ource o3 4itamin ' t,at i( ric, enoug, to maintain ,ea+t,# +e4e+( in in3ant(Jprovided the mothers too at least


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g+utamate and g+utamine among ot,er amino acid( are e2citator# in e2ce(( or in ab(ence o3 (u33icient3ue+ in t,e brain. T,e# are antagoni(tic to t,e 3unction( o3 taurine a+anine $ABA and g+#cine accordingto a contemorar# re4ie: o3 taurine b# 9ic,ard Sma#da '.O. Con(euent+# taurine doe( deto2i3#g+utamate(. Taurine ?and magne(ium@ re4ent( g+utamate e2citoto2icit# t,roug, regu+ation o3 ca+cium andmitoc,ondria+ energ# metabo+i(m according to (cienti(t( :riting in t,e No4ember 1 i((ue o3 ourna+ o3Neuro(cience. T,e# c+ear+# and unambiguou(+# oint out t,at t,e contro+ o3 intrace++u+ar ca+ciumconcentration( i( a 3undamenta+ roce(( in neurona+ (ur4i4a+ and 3unction. T,i( re4ention o3 g+utamatee2citoto2icit# i( e2act+# :,at :e need. A4oid ,#og+#cemia to a4oid e2citoto2ic reaction( cau(ed b# a+ac" o3 brain 3ue+.

Furt,ermore 4iru(e( are cau(ati4e6 T,ere are o4er !0 4iru(e( t,at ,a4e been (,o:n to cau(e (ei8ure( ineo+e inc+uding man# t,at are ubiuitou( and "no:n to ,a4e +atent (tate( :it, E(tein Barr ot,er*ere( 4iru(e( in3+uen8a Co2(ac"ie mea(+e( and mum( being among t,em. I am er(ona++# o3 t,eoinion t,at c,ronic +atent 4iru(e( :,ic, ,a4e an a33init# 3or g+ia+ ce++( are t,e main under+#ing cau(e o3idioat,ic ei+e(#.D ; o,n B. S#me( '.


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inter+eu"in;! (#nt,e(i( and ce++ ro+i3eration.D

Car+o( A. Pardo;


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in3+ammator# di(order ?In4itti !00!H Lee et a+. !00!H Santoro et a+. !00!H Sit8er et a+. !00!@. =,en a c#to"ineb+ood ro3i+e i( conducted on eo+e in a :ea"ened condition an e2ce(( +e4e+ o3 one or more o3 t,e in3+ammator#c#to"ine( e.g. TNF?a@ IL;/ IL;1?b@ or IL;% i( u(ua++# 3ound ?Santoro et a+. !00!@.

Ob(er4e t,e +i"e+# (cenarioH ,ea4# meta+( cau(e **


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3o++o:( t,e acute in3ection and i( ca++ed (ubacute (c+ero(ing anence,a+iti( ?SSPE@. T,i( t#e re(ent( it(e+3 1;10#ear( +ater a( a er(i(tent mea(+e( in3ection :it, man# mutation( in(ide t,e ce++( o3 t,e cerebe++um and (ina+ cord ineo+e :it, cometent mature immune (#(tem(. SSPE can be 3ata+ becau(e it cau(e( genera+ de(truction o3 brainti((ue +eading to rogre((i4e dementia (ei8ure( and c,ronic neuro+ogica+ di(order( a33ecting coordination.

T,e 3ina+ t#e o3 mea(+e(;re+ated com+ication in brain in3+ammation i( a rogre((i4e in3ectiou( one in eo+e:it,out cometent immune (#(tem( (uc, a( immunocomromi(ed eo+e or c,i+dren :it, immune (#(tem( t,atare (ti++ de4e+oing. T,i( 3orm mani3e(t( it(e+3 1;/ mont,( 3o++o:ing mea(+e( in3ection. Common (#mtom( inc+ude(ei8ure( motor and (en(or# (#(tem de3icit( and +et,arg# ?3atigue@ :it, t,e acute or (ub;acute rogre((ion o3 t,i(t,ird t#e o3 ence,a+iti(. T,e (#mtom( are a re(u+t o3 brain ti((ue deat, cau(ed b# unre(tricted 4ira+ re+ication:,ic, ,aen( :,en immune 3unction i( decrea(ed due to ab(ence or immaturit#. T,e(e (#mtom( o3 mea(+e(4iru( in3ection in t,e brain( o3 eo+e :it,out cometent immune (#(tem( are too (imi+ar to auti(m to ignore.5ea(+e( in3ect( (eci3ic brain area( (uc, a( t,e 3ronta+ corte2 t,a+amu( ,#ot,a+amu( (ub(tantia nigra +ocu(ceru+eu( ra,e nuc+ei ,iocamu( am#gda+a r,ina+ corte2 and cingu+ate g#ru( :,ere neuron( ,a4e (eci3icC'&/ or gro:t, 3actor recetor(. T,e(e are common+# damaged area( o3 t,e brain in auti(m.

5ea(+e( norma++# mutate( on+# one t,ird a( 3a(t a( *I


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E33ecting a cure :,en a 4iru( i( t,e o33ending agent and man# time( bringing about t,i( c,ange in t,e(,ort (ace o3 !& ,our( i( a re:arding moment in medicine.


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t,ere3ore robab+e t,at t,e bio+ogica+ 3unction o3 4itamin C can be +ocated in t,e metabo+ic reaction(:,ic, are connected :it, e+ectron tran(3er.D


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tumm#. 'ont c,i++ t,e c,i+d. Force :ater.


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uite ,ig, comared to t,e genera+ ou+ation ?1 in )00;1000@. About ! o3 t,e (ubject( ,ad Ig$(ubc+a(( de3icienc#. ?Po(iti4e Ig$ antibodie( to g+uten :ere 3ound in 100 o3 IgA;de3icient er(on( :it,bio(# ro4en ce+iac di(ea(e but :,o :ere negati4e b# t,e endom#(ia+ antibod# te(t. T,e(e Ig$antibodie( are t,oug,t to increa(e inte(tina+ ermeabi+it#;=SL@. About ! o3 t,e atient( ,ad ade3icienc# o3 4ariou( (ub(et( o3 +#m,oc#te( ?e.g. C'- C'& and C'% Ki++er T;Ce++(@. In 3act a+mo(t&0 o3 t,e(e auti(tic c,i+dren ,ad a de3icienc# in Natura+ Ki++er Ce++( ?T,1 (ure((ed@. In genera+ t,ec#to"ine( IL;! and a+,a;inter3eron are increa(ed :,i+e IL;1 i( norma+.D Ig$ anti;brain autoantibodie(:ere re(ent in !) :it, AS' and :it, ! 3rom ,ea+t,# c,i+dren. Ig5 autoantibodie( to t,e m#e+in:ere re(ent in -/ :it, AS' comared :it, 0 o3 contro+(. T,e re(ence o3 t,e(e antibodie( rai(e(t,e o((ibi+it# t,at autoimmunit# +a#( a ro+e in t,e at,ogene(i( o3 +anguage and (ocia+ de4e+omenta+abnorma+itie( in a (ub(et o3 c,i+dren :it, t,e(e di(order( ; Serum autoantibodie( to brain in Landau;K+e33ner 4ariant auti(m and ot,er neuro+ogic di(order(. Pediatr 1 5a#H 1-&?@6 /0);1-.

A Corne++ re(earc,er 9odne# 'ietert ro3e((or o3 immunoto2ico+og# at Corne++( Co++ege o3


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re(enting ce++( i( imaired b# 8inc de3icienc# a( :e++ a( b# energ# re(triction. C,i+dren :it, c+inica+ or(ubc+inica+ 4itamin A de3icienc# a+(o ,a4e dere((ed Ig$ re(on(e( to tetanu( to2oid comared :it,c,i+dren (u+emented :it, 4itamin A. T,e re(u+t( o3 more t,an t,ree decade( o3 :or" indicate t,at 8incde3icienc# raid+# dimini(,e( antibod# and ce++;mediated re(on(e(. T,e moderate de3iciencie( in 8incnoted in (ic"+e ce++ anemia rena+ di(ea(e c,ronic ga(trointe(tina+ di(order( and Acrodermatiti(Enteroat,icaH (ubject( :it, ,uman immunode3icienc# 4iru(H c,i+dren :it, diarr,eaH and t,ema+ab(ortion o3 auti(tic and e+der+# er(on( can great+# a+ter ,o(t de3en(e (#(tem( +eading to increa(e( inoortuni(tic in3ection( and morta+it# rate(. /his is liely be!a$se adeH$ate >in! is needed to releasevitamin from the liver. Cortico(teriod( ?,#rocorti(one redni(one de2amet,a(one etc.@ :i++ increa(et,e rate o3 4itamin A tran(ort 3rom t,e +i4erH ,o:e4er t,e# :i++ re(u+t in e+e4ated (erum +e4e+( andde+etion o3 4itamin A re(er4e(. Bot, 4itamin A and 8inc de3icienc# are :ide(read among our c,i+drenand arent(. T,e(e de3iciencie( ,a4e 4er# negati4e a(ect( on t,e immune 3unction.

'r. Sing, 3urt,er (tate(6 I 3irm+# be+ie4e t,at u to eig,t# ercent ?and o((ib+# a++@ ca(e( o3 auti(m arecau(ed b# an abnorma+ immune reaction common+# "no:n a( autoimmunit#. T,e autoimmune roce(( inauti(m re(u+t( 3rom a com+e2 interaction bet:een t,e immune (#(tem and t,e ner4ou( (#(tem.

Antibodie( to mea(+e( ?rubeo+a@ ?5


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neonata+ inten(i4e care unit :,o :ere gi4en t:o or more 4accine( on t,e (ame da# ?Crimina+@. A(earate grou o3 ?reemie@ in3ant( :ere gi4en one (,ot at a time e4er# t,ree da#(. T,e 4accine(admini(tered :ere 'TaP *ib o+io YIP


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P#rido2ine deendenc# i( robab+# more common t,an re4iou(+# t,oug,t and (igni3icant imro4ementma# be (een :it, aroriate treatment e4en i3 t,e diagno(i( i( de+a#ed.D

One o3 t,e more recent (tudie( on T#e I diabete( :a( ub+i(,ed in !001 in t,e Lancet. T,i( articu+ar reortconcerned a -1;#ear ro(ecti4e (tud# o3 o4er 10000 c,i+dren born in 1// in nort,ern Fin+and. T,e arent( :eread4i(ed to gi4e t,e c,i+dren !000 IX o3 4itamin ' er da#. A #ear +ater t,e re(earc,er( 3o++o:ed u :it, t,e3ami+ie( to determine :,ic, c,i+dren ,ad been gi4en t,e 4itamin '@ :,ic, ,ad not and i3 an# o3 t,em ,ad (ign( o3

ric"et( ?cau(ed b# (e4ere 4itamin ' de3icienc#@. T,e c,i+dren :,o :ere regu+ar+# gi4en t,e (u+ement during t,eir3ir(t #ear ,ad aro2imate+# %0 +e(( t#e I diabete( diagno(ed o4er t,e ne2t -1 #ear( In (,ar contra(t t,o(ec,i+dren :,o (,o:ed (ign( o3 ric"et( at age one ,ad -00 more t#e I diabete( diagno(ed o4er t,e ne2t -1 #ear(.A (tud# 3rom Ita+# con3irm( t,e +ac" o3 4itamin ' in ne:+# diagno(ed T#e 1 diabete(. 5oreo4er it i( t,oug,t t,at4itamin '-(u+ementation in articu+ar it( acti4ated 3orm 1;di,#dro2#4itamin '-Y1!;?O*@!'-R ma# act a(an immunomodu+ator 3aci+itating t,e (,i3t 3rom a T,! to a T,1 immune re(on(e according to (cienti(t( :riting int,e journa+ *ormone and 5etabo+ic 9e(earc,.

9ecent re(earc, b# 5ar(,a++ et a+ in (arcoido(i( and Cro,n( (,o:( t,at t,e acti4e 3orm o3 t,e 4itamin ' ,ormone?1! '@ i( re(ent in e2ce((i4e +e4e+( re+ati4e to t,e inacti4e ! ' 3orm in atient( diagno(ed :it, a number o3in3+ammator# i++ne((e( (uc, a( c,ronic 3atigue (#ndrome 3ibrom#a+gia and L#me di(ea(e. E4idence (ugge(t( t,att,i( i( due to unregu+ated roduction o3 1! 4itamin ' b# macro,age( in t,e cour(e o3 an e2ce((i4e T,1 immunere(on(e. 9e(earc, indicate( t,at t,i( occur( in re(on(e to ce++;:a++;de3icient ?L;3orm@ bacteria ara(iti8ing ?ta"ingu re(idence :it,in@ immune ce++( and ot,er ti((ue. Te(ting 3or t,e acti4e 1 ! ?O*@ ' mu(t be done :it, 3ro8enurine (am+e( b# LabCor :,o u(e( a more re+iab+e +o: co(t te(t met,od. A ,ig, 1! ?O*@ ' to ! ?O*@ ':ou+d (ugge(t in3ection b# L;3orm bacteria.

X(ua++# t,e in3+ammation cau(ed b# autoimmunit# ?(ic@ i( treated b# (ure((ion o3 t,e immune (#(tem. T,i( (eem(to :or" but :it, a ,ig, rice tag in (ide e33ect(. It :ou+d (ure+# be better to get at t,e cau(e. 9e(earc,er( 3romEin(tein Co++ege o3 5edicine o3 e(,i4a Xni4er(it# and ot,er( recent+# conducted a (tud# o3 autoimmune mice.T,e(e mice u(ua++# get 3ata+ autoimmune "idne# di(ea(e and die b# age ! mont,(. T,o(e recei4ing norma+ dietar#amount( o3 Indo+e;-;carbino+ ?I-C@ a +ant comound 3rom cruci3erou( 4egetab+e( +i4ed to t,e ,uman eui4a+ent o31!0 #ear( ?T,i( (ub(tance i( 3ound in P,#t;A+oe_ b# 5annatec, Inc.@ It i( robab+e t,at t,i( e33ect i( due to t,e

modu+ation o3 t,e roce(( o3 met,#+ation b# t,e I-C. 5et,#+ation decrea(e( :it, age i( di(ruted b# autoimmunit#and I-C en,ance( t,i( +i3e;(u(taining roce((. T,e(e cruci3erou( 4egetab+e( a+(o great+# en,ance roduction o3$+utat,ione and $+utat,ione Pero2ida(e t,at (trengt,en t,e immune 3unction and t,e deto2i3ication ?c+ean(ing@caabi+itie( o3 t,e bod#. Indo+e;-;carbino+ i( imortant in norma+i8ing c,emica++# (en(iti4e eo+e 3or t,e 3ood andc,emica+( t,e(e da#( are ,ig, in (eudoe(trogen comound( and dio2in. T,e antidote 3or dio2in ?TC''@ i( indo+e;-carbino+. T,i( mig,t ,e+ norma+i8ed (ome c,i+dren( be,a4ior. 5# re(earc, ,a( (,o:n t,at t,e c,ie3 t,eraeuticinter4ention to re4ent :eig,t gain ?regard+e(( o3 age@ i( t,e anti;in3+ammator# diet. I ,a4e ob(er4ed (igni3icant:eig,t +o(( in t,ou(and( o3 indi4idua+( :,o 3o++o: t,e (im+e 3ormu+a o3 a4oiding 3ood( t,at are ro;in3+ammator#and c,oo(ing in t,eir +ace 3ood( :it, anti;in3+ammator# roertie(.D ; 'r Nic,o+a( Perricone 5'.

9eed =arren et a+ mention ,o: t,e IgA 3inding( re+ate to in3ection( and reort a 3a(cinating doub+e(u(cetibi+it# in t,at (i2 o3 eig,t auti(tic "id( :it, +o: IgA +e4e+( a+(o ,ad nu++ a++e+e( o3 t,e com+ement

C&b6 ...IgA i( a+(o imortant in rotection again(t at,ogenic in3ection( and articiate( in t,e c+earanceo3 at,ogen( 4ia t,e a+ternati4e com+ementD at,:a#. C& rotein( Ye.g. 3rom t,e C&a and C&b gene(Rare in4o+4ed in t,e ot,er com+ementD at,:a# t,e c+a((ica+ com+ement at,:a#. T,ere3ore it i(intere(ting t,at o3 t,e eig,t auti(tic (ubject( :it, decrea(ed IgA +e4e+( a++ but t:o a+(o ,ad a C&b nu++a++e+e (ugge(ting t,at in t,e(e atient( bot, at,:a#( o3 com+ement acti4ation Yand re(on(e toin3ection(R are robab+# oerating at +e(( t,an otima+ +e4e+.D

I3 t,e# are 4itamin A de3icient are t,e# roducing (ecretor# IgA7 5an# o3 t,e(e c,i+dren ,a4e ,adrecurrent ga(trointe(tina+ andGor re(irator# in3ection( and otiti( media beginning at 1;1% mont,(.Adeuate 4itamin A i( needed to roduce (ecretor# IgA and to ,ea+ ci+iated membrane( inc+uding t,o(e

-0


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t,at (ecrete IgA. To re+ace #our mucou( (ecreting ce++( #ou need 4itamin A. To create (ecretor# IgA#ou need t,o(e ce++( ,ea+t,# and t,e(e c,i+dren need 4itamin A to rebui+d retinoid recetor( a((ociated:it, $;rotein a++ o4er t,e bod#D ; 'r. 5ar# 5eg(on 5'.

A te(t o3 t,irt#;(i2 c,i+dren re4ea+ed grade I or II re3+u2 e(o,agiti( in ! ?/.&@ ?4accine induced7@c,ronic ga(triti( in 1 ?&!@ and c,ronic duodeniti( in !& ?/)@. Lo: inte(tina+ carbo,#drate dige(ti4een8#me acti4it# :a( reorted in !1 c,i+dren ?%.-@ a+t,oug, t,ere :a( no abnorma+it# 3ound in

ancreatic 3unction. Se4ent#;3i4e ercent o3 t,e auti(tic c,i+dren ,ad an increa(ed ancreatico;bi+iar# 3+uidoutut a3ter intra4enou( admini(tration o3 Secretin ?indicating ,#er(en(iti4it# o3 t,e ancrea(@;$a(trointe(tina+ abnorma+itie( in c,i+dren :it, auti(tic di(order. Pediatr 1 No4H1-?@6;/-.

C,i+dren :it, auti(m roduce ,ig,er +e4e+( o3 ro;in3+ammator# c#to"ine( ?a +oca+i8ed rotecti4ereaction o3 ti((ue to irritation injur# or in3ection c,aracteri8ed b# ain redne(( (:e++ing and (ometime(+o(( o3 3unction.@ t,an c,i+dren :it,out auti(m. A +ac" o3 (+ee mar"ed+# increa(e( in3+ammator#c#to"ine( e(ecia++# IL;/ :it, an a4erage o3 &0;/0 increa(e in men and :omen. 5en ob(er4ed a !0;-0 increa(e in TNF?a@ a+(o.

'uring t,e rogre((ion o3 5g de3icienc# in a rodent mode+ dramatic increa(e( o3 in3+ammator# c#to"ine(:ere ob(er4ed articu+ar+# in inter+eu"in( 1 and / ?IL;1 IL;/@ and tumor necro(i( 3actor ?TNF@. ?In

addition to attac"ing tumor ce++( (e+ecti4e+# TNF i( acti4e again(t 4iru(;in3ected ce++(. E2ce(( TNF i("no:n to reduce 4a(cu+ar b+ood 3+o: increa(e o2idati4e (tre(( reduce g+utat,ione +e4e+( increa(e bonere(ortion (ure(( m#e+in 3ormation comete :it, in(u+in at recetor (ite( damage ancreatic;betace++( :it, a+de,#de( and induce ce++ deat,.@

A +andmar" in our under(tanding o3 c#tomega+o4iru( ?C5


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c#to"ine( b# u to 0 ?ame( et a+. !000@. '*A i( e((entia+ to memor# and to retina+ 3unction and(,ou+d be 3a4ored o4er EPA in our (u+ement(.

'r. =e(ton Price ob(er4ed t,at a 3e: dro( o3 CLO :it, a 3e: dro( o3 Butter oi+ under t,e tongue re4i4ed t,ei++ but (ing+# t,e# did not =e no: "no: t,e butter oi+ i( ric, in 4itamin K! and t,at t,e t,ree nutrient( aree((entia+ to t,e ,and+ing o3 ca+cium. Lauric acid o3 butter coconut oi+ and 5ot,er( mi+" imro4e( t,e 3unctiono3 t,e Omega;/ at,:a# and enab+e( t,e 3att# acid( to accumu+ate in t,e ti((ue( :,ere t,e ro(tag+andin( are

3ormed.


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5aier a+(o (,o:ed t,at ,ig, +e4e+( o3 (tre(( a+one cou+d roduce t,e(e (ame immune re(on(e( and ma"e#ou (ic" E2ce(( corti(o+ ,a( been (,o:n to roduce ,#erten(ion oor :ound ,ea+ing bone +o((mu(c+e :a(ting t,in ("in and (+ee 3ragmentation. *ig, corti(o+ induced b# (tre(( cau(e( bot, in(u+inre(i(tance and t,#roid ,ormone re(i(tance :,ic, increa(e( t,e e(trogen burden Xn3ermented (o#contribute( a ,ig, e(trogen inut a( :e++. '#(bio(i( and oor dige(tion re4ent( t,e bod# 3rome+iminating unnece((ar# e(trogen. E2ce(( e(trogen bind( t,e t,#roid tran(ort rotein( (o t,e t,#roid,ormone( cannot get to t,e ce++( cau(ing ,#ot,#roid (#mtom(.D ; 'r 'ati( K,arra8ian '*Sc 'C5S. Iodine di(arm( e(trogen and reduce( #our cancer ri(" T,i( a+(o ,e+( re(tore an o+der man(te(to(teroneGe(trogen ba+ance re4enting man# (#mtom( inc+uding big boob( Corti(o+ i( a "i++er o3brain ce++( e(ecia++# in t,e ,iocamu( a33ecting memor# ad4er(e+#H but it a+(o drain( #our immune3unction and ma"e( #ou dere((ed ?e2ce(( corti(o+ (ure((e( ce++u+ar immune re(on(e( and de(tro#(immature T;ce++( (,i3ting to T,! dominance@ C,ronic (tre(( (uc, a( t,e(e c,i+dren ?and #ou 5om(@(u33er increa(e( be,a4iora+ bioc,emica+ ,ormona+ ,#(io+ogica+ and (#c,o+ogica+ re(on(e( and ut(an# e2ce(( 3at on #our midd+e ?4i(cera+ 3at t,e mo(t dangerou( "ind@

Additiona++# i(o+ation :it,out (ocia+ (uort a+(o rai(e( corti(o+. 5om( ta"e time to re+a2 and (ocia+i8e 'o adai+# re+a2ation;meditation e2erci(e. Ta"e a 4igorou( !0;minute :a+" in t,e (un bring t,e c,i+dH ,e need( t,ee2erci(e and t,e (un a( muc, a( #ou. *e :i++ eat and (+ee better a( :i++ #ou. ou mig,t :ant to con(ider

9,odio+a 9o(ea an ,erba+ adatogen t,at en,ance( energ# ?burn( ca+orie(@ and menta+ 3unction( and ta"e !00to &00 mcg o3 c,romium ?not ico+inate@ t,at reduce( Corti(o+ b# &). Te(t( :it, 4itamin C ?1000;-000mgGda#@ (,o:ed (igni3icant +o:ering o3 corti(o+ and b+ood re((ure a3ter ,#(ica+ and (#c,o+ogica+ (tre((.T,ree mg o3 me+atonin be3ore bedtime reduce( 4i(cera+ 3at.

);Keto '*EA :a( (,o:n a+(o to reduce dia(to+ic b+ood re((ure increa(e neutro,i+( t,e 3ir(t :,ite b+oodce++( to re(ond to in3ectionH and it counteracted t,e e33ect o3 g+ucocorticoid( (uc, a( corti(o+. =,en mice :it,comromi(ed immune 3unction :ere (ubjected to mi+d (tre(( 3or one mont, a +ong time in a mou(e( +i3e t,eir:,ite b+ood ce++( and t,#roid ,ormone( :ere decrea(ed ,o:e4er :,en t,e# gi4en );Keto '*EA at 1 mgG"gt,eir b+ood ce++( ro+i3erated and Natura+ Ki++er Ce++ acti4it# :a( dramatica++# en,anced. T,#roid +e4e+( returnedto norma+. Xn+i"e '*EA );Keto doe( not a33ect (e2 ,ormone +e4e+(. Li3e E2ten(ion Foundation ,a( acombined (u+ement o3 '*EA and );"eto ?'*EA Com+ete@.

=,en ce++u+ar immune 3unction ?T,1@ i( decrea(ed antibodie( are great+# increa(ed. Con4er(e+# :,ence++u+ar immune 3unction i( re(tored antibodie( decrea(e. T,e attern o3 antibod# re(on(e a+(o :i++ 4ar#a( t,e antigen +oad c,ange( ua+itati4e+# and uantitati4e+#. I under(tand t,i( to mean t,at ,ig, antibodie(to an antigen indicate a re(ent ,ea4# +oad o3 t,at in3ectiou( agent. ?Lo: +#m,oc#te( and ,ig,monoc#te( ma# be (imi+ar+# indicati4e o3 c,ronic in3ectionGin3+ammation.@

Intractab+e c,i+d,ood ei+e(# i( a((ociated :it, +o: b+ood 4a+ue( o3 Ig$;! and Ig$;&H re+acementt,era# ma# +ead to remi((ion o3 (#mtom(. Ig$;& ma# a+(o be +o: in (ome c,i+dren :it, 3ebri+econ4u+(ion(. T,e anti(ei8ure drug carbama8eine ?TegretolTM@ ma# cau(e a reduction in Ig$;! :,i+e,en#toin ?DilantinTM@ ma# be a((ociated :it, decrea(e( in IgA Ig$;- and Ig$;&. Anti;IgA antibodie(,a4e been detected in ei+etic atient( :it, +o: (erum IgA concentration(. In c,i+dren :it, t,e(eabnorma+ antibod# attern( (e+enium ?Se@ (u+ementation at a do(e o3 10;mcgG"g bod#:eig,t 3or (i2mont,( (igni3icant+# increa(ed Ig$;! and Ig$;& +e4e+( and reduced t,e number o3 in3ection(. Lo: b+ood4a+ue( o3 t,e(e t:o immunog+obu+in antibodie( are a((ociated :it, intractab+e (ei8ure(. Se+enium and4itamin E (u+ementation ,a4e o4ercome intractab+e (ei8ure( t,at :ere re(i(tant to drug(. Xnder norma+condition( a Se inta"e o3 +e(( t,an 1000 gGda# ?or 1 gGKg bod#:eig,t@ doe( not cau(e to2icit#.Peo+e in art( o3 C,ina t,e XS


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Bot, (e+enium and 4itamin E de3iciencie( are "no:n to indeendent+# (timu+ate t,e 3ormation o3antibodie(. Studie( ,a4e (ugge(ted t,at Se ro4ided in certain 3orm( can neutra+i8e carcinogen( and ,ea4#meta+( en,ance t,#roid and immune (#(tem 3unction re4ent ,arm3u+ mutation o3 4iru(e( 3a4orab+# a+tergene ?inc+uding -@ e2re((ion in,ibit tumor ce++ metabo+i(m and neo;angiogene(i( ?b+ood 4e((e+de4e+oment around tumor(@ and romote aoto(i( ?rogrammed ce++ deat,@. Ot,er (#mtom( o3(e+enium ?Se@ de3icienc# ma# be mu(c+e ac,e( ain( and :ea"ne(( tender t,ig,( and di(com3ort in:a+"ing. T,ere ma# be ("in rob+em( and in3erti+it#. C,i+dren ma# not gro: roer+#. Se aear( to bein3+uentia+ in t,e brain and (e4era+ (tudie( t,at indicate +o: Se +e4e+( are a((ociated :it, cogniti4eimairment dere((ion an2iet# into+erance and ,o(ti+it#. T,e(e condition( can be a++e4iated inindi4idua+( :it, +o: ba(e+ine Se +e4e+( b# Se (u+ementation. 9ecent (tudie( (ugge(t t,at (e+enoroteinP (e+enorotein =) and (e+enorotein 5)/ ,a4e imortant ro+e( in t,e brain. T,e 4ita+ need 3or(e+enium in t,e brain i( indicated in t,at it ,oard( t,e a4ai+ab+e (e+enium :,en it i( +ac"ing. Se 3orm((e+enide( :it, a++ meta+( and deto2i3ie( mercur# cadmium +ead (i+4er t,a++ium and ar(enic. T,i( e33ectcan be en,anced b# 4itamin E. Ne: Mea+and Fin+and Serbia and certain countie( in C,ina ,a4e t,e+o:e(t (e+enium in t,e :or+d. T,e Nort,:e(t Nort,ea(t and Sout,ea(t Xnited (tate( ,a4e +o: +e4e+( int,e (oi+. Se+enium +e4e+( +ummet a3ter (urger# injur# in3ection b+ood +o(( and :it, ad4ancing age ?Amourna+ o3 C+inica+ Nutrition Oct 1)@. A +ac" o3 (e+enium induce( T- de3icient ,#ot,#roidi(m. Fi(, and:,eat are t,e ric,e(t (ource( o3 (e+enium. T,oug, 3i(, i( ,ig, in (e+enium ta"ing 0;mcg (e+enium :it, a

3i(, mea+ en(ure( binding o3 t,e mercur#.*uman ou+ation( e2o(ed en4ironmenta++# to ar(enic ,a4e a ,ig, incidence o3 b+adder "idne# +i4er and ("incancer ?Kitc,in !001@. One (tud# (,o:ed t,at t,o(e :it, T#e ! diabete( ,ad !/ ,ig,er +e4e+( o3 ar(enic t,ant,o(e :,o :ere 3ree o3 t,e di(ea(e. T,o(e :it, t,e ,ig,e(t +e4e+( o3 ar(enic :ere 3our time( more +i"e+# to ,a4e t,edi(ea(e t,an t,o(e :,o ,ad t,e +o:e(t +e4e+( o3 ar(enic. 5ot,er( o3ten a(" :,ere t,e ,ig, ar(enic +e4e+( 3ound int,eir c,i+dren come 3rom. It can come 3rom +a#ground( :,ere :ood :a( treated :it, ar(enic t,at ,a( no:contaminated t,e (and in t,e (andbo2 3rom t,e dec"ing around #our ,ou(e +a(tic +a#en adding :oo+ rug andunder+a#( but +arge+# it ma# come 3rom #our drin"ing :ater. 5an# :ater( ,a4e (igni3icant amount( o3 ar(enic. A("#our agenc# 3or a +ab reort on :ater content. Ar(enic e2o(ure in mice (ure((ed t,e Ig5 and Ig$ antibod#3orming ce++ re(on(e in,ibited antigen dri4en T;ce++ ro+i3eration and macro,age acti4it# decrea(ed C'& (+enic

ce++ number and (ure((ed contact ,#er(en(iti4it# re(on(e( ?Burn( and 5un(on 1-H Patter(on et a+. !00&HSi"or("i et a+. 1%@. In ot,er :ord( it de(tro#( t,e norma+ immune re(on(e. One o((ib+e mec,ani(m 3oren,anced tumorigene(i( in ar(enic;e2o(ed ou+ation( i( t,at damage to t,e immune (#(tem imair( t,e re(on(e(to tran(3ormed ce++( ?Andre( !00@. In 3act in,ibition o3 +#m,oc#te ro+i3eration in re(on(e to,#to,emag+utinin ?P*A a +ectin 3ound in +egume(@ (timu+ation ,a( been reorted in adu+t ,uman ou+ation(e2o(ed to ar(enic contaminated drin"ing :ater. No: Soto;Pena et a+. ?!00/@ demon(trated t,at ro+i3eration o3eri,era+ b+ood mononuc+ear ce++( in re(on(e to P*A :a( (igni3icant+# decrea(ed in a((ociation :it, an increa(ein ar(enic concentration in urine o3 c,i+dren /10 #ear( o3 age e2o(ed c,ronica++# to ar(enic. 9e+ea(e o3inter+eu"in;! ?a T;ce++ gro:t, 3actor@ 3rom t,e(e ce++( :a( a+(o (igni3icant+# (ure((ed. Studie( t,at demon(trate(igni3icant immune (ure((ion in c,i+dren e2o(ed to en4ironmenta++# re+e4ant +e4e+( o3 a to2icant are not acommon occurrence (o t,i( ca(e i( articu+ar+# notab+e.

T,e antibod# re(on(e to di,t,eria to2oid decrea(ed at age 1% mont,( b# !& 3or eac, doub+ing o3 t,ecumu+ati4e PCB e2o(ure at t,e time o3 e2amination. At !;#ear( o3 age !1 o3 c,i+dren ,ad di,t,eria to2oidantibod# concentration( be+o: t,e +imit 3or +ong;term rotection. T,e *ei+mann (tud# (ugge(t( t,at c,i+drene2o(ed to PCB( in utero or (oon a3ter birt, are at greater ri(" o3 in3ection and in 3act (tudie( ,a4e (,o:n anincrea(ed 3reuenc# o3 c,i+d,ood in3ection( in c,i+dren :,o ,a4e been e2o(ed to PCB( and ot,er organoc,+orineo++utant( 4ia t,eir mot,er( contaminated diet ?'a++aire et a+. !00/H 'e:ai++# et a+. !000H Naga#ama et a+.1%H=ei(g+a(;Kueru( et a+. !000@. Simi+ar (tudie( :it, cigarette;(mo"ing mot,er( and in anima+( :it, to2in( o3 man#"ind( (,o: (ure((ion o3 t,e immune 3unction in o33(ring.

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Additiona++# in :or"er( e2o(ed to 3+uorine t,o(e :it, (ubc+inica+ ,#ot,#ro(i( Yreduced tri;iodot,#ronine ?T-@ in 1R ,ad immune a+teration( t,at :ere more e4ident. T;+#m,oc#te( count ro(ebut t,eir 3unctiona+ acti4it# dec+ined indicating imaired cooeration o3 immunoc#te( a( a re(u+t o3imer3ect contro+ under +o: concentration( o3 T- ?Ba+abo+"in 1@. Some con4ert T- into t,e inacti4ere4er(e T- and t,u( ,a4e a re+ati4e de3icienc# o3 t,e acti4e ,ormone ?=i+(on( S#ndrome@. T,eirimmune (#(tem i( dri4ing :it, no bra"e( Additiona++# in ab(ence o3 T- a ner4e 3iber :i++ not conduct animu+(e


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=e ,a4e ob(er4ed t,e c,ronic in3ection( re(ent and t,e e33ect uon t,em o3 4ariou( nutrient(. T,i(ab(tract i( (o 4ita+ to t,e reco4er# 3rom auti(m t,at I uote it in it( entiret#6

Ear+# 'iagno(i( o3 A+8,eimer( 'i(ea(e and Auti(m b# Non;In4a(i4e+# 5ea(uringAcet#+c,o+ine ;Am#+oid ?1;&!@ A+ *g and


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Se+ecti4e 'rug Xta"e 5et,od to t,e brain i( er3ormed eit,er b# (timu+ation o3 t,e brainrere(entation area at t,e 1(t (egment o3 t,e midd+e 3inger eit,er mec,anica++# or b# red (ectra++ig,t 3rom LE'. 5ore t,an o3 t,e e2ce(( meta+ deo(it in ,iocamu( and re(t o3 brain canbe remo4ed u(ing Ci+antro and Se+ecti4e 'rug Xta"e En,ancement to (e+ecti4e+# de+i4er t,eCi+antro to t,e brain :it,in (e4era+ ,our(. Once t,e major art o3 e2ce((i4e deo(it o3 meta+ i(remo4ed 3rom brain Acet#+c,o+ine o3ten increa(e( ! or - o3 t,e origina+ abnorma++#;reducedamount :it,out an# ot,er treatment. =it,in t,e a(t ! #ear( t,e aut,or di(co4ered t,at t,e t:omajor cau(e( o3 t,e increa(e in :ater in(o+ub+e ;Am#+oid ?1;&!@ i( due to brain in3ection?articu+ar+# ,iocamu(@ o3 C,+am#dia trac,omati( and 5#cobacterium tubercu+o(i(. T,eaut,or a+(o (ucceeded in reducing in a majorit# o3 t,e atient( ;Am#+oid ?1;&!@ to norma+ +e4e+and in more t,an )0 o3 t,e atient( not on+# (toed t,e rogre(( o3 A+8,eimer( 'i(ea(e andAuti(mH but a+(o o3ten :a( ab+e to (ucce((3u++# re4ert to norma+ condition b# treating C,+am#diatrac,omati( and 5#cobacterium tubercu+o(i( (ucce((3u++# i3 t,e atient :a( diagno(ed :it,in ! or- #ear(.

T:o #ear( ago t,e aut,or 3ound t,at t,e mo(t common major cau(e o3 increa(e in ;Am#+oid ?1; &!@ in brain i( C,+am#dia trac,omati( in3ection o3 t,e brain. In !00! t,eaut,or 3ound in a :oman atient t,at ,e :a( ab+e to reduce t,e amount o3 ;Am#+oid

?1;&!@ 3rom 1!ng to /ng b# treating ,er C,+am#dia trac,omati( in3ection o3 more t,an100ng but ,e cou+d not reduce it an# 3urt,er. Xon 3urt,er e4a+uation o3 t,e brain t,eaut,or 3ound e2ten(i4e 5#cobacterium tubercu+o(i( in3ection o3 &0 gH and t,e (,ort;termmemor# de3icienc# cou+d not be e+iminated in t,i( -0;#ear;o+d :oman. In addition (,e ,adC5< in3ection and **


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(ame time. T,e Indigo +ant i( "no:n emirica++# to ,a4e bene3icia+ e33ect on (ome o3'iabetic atient(. According to t,e aut,or( c+inica+ re(earc, t,e mo(t common cau(e o3'iabete( i( C5< in3ection C,+am#dia trac,omati( in3ection or mi2ed in3ection o3 t,eC5< and C,+am#dia trac,omati(. Since t,e aut,or 3ound t,at Indigo P+ant i( bene3icia+ 3or'iabete( on+# due to C,+am#dia Trac,omati( in3ection :,i+e it i( not e33ecti4e 3or 'iabete(due to C5< a+one *a#a(,ibara Bioc,emica+ Laborator# e2tracted ;major comonent(o3 Indigo P+ant 3or t,e aut,or to e4a+uate. A++ o3 t,e origina+ ;e2tract( :ere to2ic and,ad no bene3icia+ e33ect(. *o:e4er a3ter t,e aut,or di+uted a++ o3 ;e2tract( ! - and& t,en t,e aut,or 3ound on+# one o3 to be bene3icia+ 3or C,+am#dia trac,omati(in3ection. T,i( (ub(tance Indigo ;1 i( an e33ecti4e 3orm o3 one o3 t,e ;majorcomonent( o3 Indigo +ant t,at t,e aut,or 3ound to ,a4e an anti;C,+am#dia trac,omati(e33ect.

Origina++# :,en comonent( :ere i(o+ated b# 'r. Fu"uda and ,i( a((ociate( o3 *a#a(,baraBioc,emica+ Laborator# o3 O"a#ama Cit# aan t,e aut,or 3ound t,at it ,a( a de3inite anti;C,+am#dia trac,omati( e33ect but un3ortunate+# it( e33ecti4e duration :a( an a4erage o3 one,our and t,ere3ore :e cou+d not treat t,e atient e33ecti4e+# a( no atient :ant( to ta"emedicine 1! time( a da#. To (o+4e t,i( rob+em :,en t,e aut,or and *a#a(,ibara Bioc,emica+

re(earc,er( (+ig,t+# modi3ied origina+ natura+ rearation o3 e33ecti4e comonent to ro+ong t,eduration it( e33ecti4e duration :a( en,anced to an a4erage o3 /;% ,our(H a( a re(u+t t,e aut,or3ound it ,ad a mo(t o:er3u+ anti;C,+am#dia e33ect but a+(o no "no:n (ide e33ect. =e namedt,i( natura+ (ub(tance a( Sub(tance MD. Sub(tance MD ,a( additiona+ ad4antage( name+# it i(comatib+e :it, mi2ture o3 EPA['*A it i( comatib+e :it, Trimo2 and it i( comatib+e :it,Sai"o"ei(,ito. T,u( (ince !00! it become( o((ib+e to treat 5#cobacterium tubercu+o(i( andC,+am#dia trac,omati( at t,e (ame time a+ong :it, ot,er bacteria+ in3ection( (en(iti4e toTrimo2 and 4ira+ in3ection (en(iti4e to t,e mi2ture o3 EPA[ '*A a( an anti;4ira+ agent. =e3ound t,at :e cou+d treat a atient :it, a++ t,e(e mu+ti+e in3ection( inc+uding 4ira+ in3ection(en(iti4e to mi2ture o3 EPA['*A bacteria+ in3ection (en(iti4e to Trimo2 C,+am#diatrac,omati( (en(iti4e to Sub(tance MD and 5#cobacterium tubercu+o(i( (en(iti4e toSai"o"ei(,ito ?once otima+ do(e o3 eac, medication i( determined 3or eac, indi4idua+ atient@a++ at t,e (ame time :it,out t,e mutua++# cance+ing e33ect o3 drug interaction(. In addition :eu(e (e+ecti4e drug;uta"e en,ancement de+i4ering drug( (e+ecti4e+# to t,e at,o+ogica+ area o3t,e brain b# (timu+ating an organ rere(entation area o3 t,e brain on t,e 3ir(t (egment o3 t,emidd+e 3inger( or t,e brain rere(entation area o3 t,e under(ide o3 t,e tongue or t,e ear +obu+e(b# eit,er mec,anica+ (timu+ation or red (ectra+ +ig,t (timu+ation. A( a re(u+t :e are no: ab+e to(igni3icant+# e+iminate mo(t o3 t,e in3ection( :it,in a 3e: da#( and to e+iminate t,e abo4e +i(tedabnorma+ 3inding( in t,e brain.

In t,e norma+ brain ;Am#+oid ?1;&!@ i( +e(( t,an -ng but :,en it increa(e( abo4e & or ng o3ten eo+e de4e+o (,ort;term memor# de3icienc# and :,en it( increa(e( bet:een) and 1!ng it i( con(idered to be ear+# (tage o3 A+8,eimer( di(ea(e. Acet#+c,o+ine

norma++# (,ou+d ,a4e at +ea(t 100g but brain d#(3unction began to aear becomingnoticeab+e b# ot,er( :,en it( reduced be+o: 00g. In ear+# (tage( o3 A+8,eimer(di(ea(e it goe( do:n bet:een !00 and 100g and in mo(t o3 t,e ad4anced A+8,eimer(atient( Acet#+c,o+ine i( be+o: 10;100g. =it, t,e +ate(t e33ecti4e (a3e treatmentde(cribed abo4e :,en :e e+iminate mo(t o3 t,e in3ection( to ractica++# 8ero (uc, a(C,+am#dia trac,omati( and 5#cobacterium tubercu+o(i( are ^+ 8g ?10;!1g@ (,ort;termmemor# de3icienc# :i++ di(aear articu+ar+# :,en ;Am#+oid ?1;&!@ become +e(( t,an! or - ng. *o:e4er in t,e ad4anced o+d A+8,eimer( atient :,en t,e ;Am#+oid i(increa(ed to 1! or !0ng 3or a eriod o3 more t,an - or & #ear( o3ten neuron( are a+read#damaged irre4er(ib+#. A( a re(u+t e4en :,en :e (ucceed in +o:ering ;Am#+oid ?1;&!@

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to +e(( t,an ! or - ng (,ort;term memor# 3ai+ure cannot be re4er(edH t,ere3ore it i( mo(timortant to ma"e ear+# diagno(i( and treat t,em a( uic"+# a( o((ib+e.

Simi+ar+# in Auti(m atient( t,e rob+em u(ua++# (tarted at t,e time o3 birt, but mo(t o3 t,e arent(and ,#(ician( on+# recogni8e it :,en c,i+dren reac,e( 1 1G! or ! #ear( o+d and t,u( it i( imortantto detect non;in4a(i4e+# abo4e de(cribed abnorma+ bioc,emica+ c,ange( and in3ection(. Idea++#t,e# (,ou+d be e2amined (,ort+# a3ter birt,. In t,e ca(e o3 Auti(m ?un+i"e ad4anced A+8,eimer(

atient@ o3ten it i( o((ib+e to re4er(e artia++# and (ometime( e4en (igni3icant+# :it, more t,an -or &;#ear ,i(tor#. End o3 Ab(tract.

F+uoride i( a (courge and utting it in cit# :ater i( a crimina+ act again(t t,e American eo+e T,ere3ore:e mu(t ta"e re(on(ibi+it# 3or our o:n ,ea+t,6 Eat more 3ood( ,ig, in iodine ca+cium and 4itamin( Cand ' and (u+ement iodinc to reduce t,e ab(ortion o3 3+uoride b# t,e bod# and to romote t,ee2cretion o3 3+uoride 3rom t,e bod# to en(ure better ,ea+t, 3or eo+e in t,e ,ig, 3+uoride region(.

F+uoride( damage t,e $S* and SO' en8#me( and act muc, +i"e dio2in :,ic, :or"( 4ia t,i( en8#meroce(( to create reacti4e o2#gen (ecie( ?9OS@ damage. T,ere :ere airG+ung at,:a# e33ect( (oi+contaminationG3ood at,:a#( into t,e ga(trointe(tina+ (#(tem and ground and (ur3ace :ater at,:a#(into communitie(. T,e(e at,:a#( 3or 3+uoride( connected t,em :it, t,e CFS;+i"e (#mtom( and a(t,ma

(een in :or"er( and communitie(. A(t,ma i( direct+# connected to reduced $S* and SO'. T,e :or"er(,ad ,ig, +e4e+( o3 ca+cium t,at i( indicati4e o3 3+uoride e2o(ure. T,e# a+(o ,ad ,ig, retention o3 meta+(and ,ig, or,#rin. Por,irine and or,#rin( are diagno(tic indicator( o3 to2ic;ce++ damage e33ect( 3rommeta+( and c,emica+(.

F+uoride( are u++ed into t,e +#m, node( and t,e a33init# o3 3+uoride 3or ca+cium roduce( an in(o+ub+ereciitate t,at i( (imi+ar to t,e e33ect( cau(ed b# t,e in(o+ub+e meta+(. T,e e33ect (et( u TNF?a@ and ,#er;o2#gen ?9OS@ damage t,at +oca++# +o:er( g+utat,ione in t,e +#m, ce++(. TNF?a@ romote( 4ira+ 9NAre+ication. Increa(ing 4ira+ in3ection in t,e t#e;I macro,age( romote( more TNF?a@ and t,i( i( mu+ti+ied b#t,e reeating e33ect o3 ce++( in t,e +#m, (#(tem. T,i( acti4ation o3 t,e T;ce++ ,e+er;1 ?T,1 ; Natura+;"i++er ce++(@roce(( a+(o (et( u a (:itc, to T;ce++ ,e+er;! ?T,! ; antibod#@ mode (+o:+# a( t,e macro,age( (to :or"ing

and 3oreign;ce++ roduct( accumu+ate in t,e ti((ue( t,at trigger t,e T,! mode.T,e 3+uoride damage to t,e en8#me roce((e( +i"e g+utat,ione ?$S*@ and ot,er( +i"e it (et u 3actor(t,at re(u+t in retention o3 t,e +et,a+ meta+( (uc, a( mercur# cadmium +ead nic"e+ and ot,er(. T,i( re(u+t(in t,e aearance o3 er(on( :it, ,ig,;3+uorine e33ect( ,a4ing ,ea4#;meta+ oi(oning. T,e 3+uoride e33ectdri4ing t,e retention o3 meta+( +i"e mercur# add( dramatica++# to:ard t,e ner4ou(;(#(tem damage and+o(( o3 T;ce++(. T,e +o(( o3 $S* and ot,er c+earing en8#me( re(u+t( in a (ee;(a: +i"e e33ect :,ere t,ebene3icia+ trace e+ement( (uc, a( (e+enium 8inc magne(ium and coer are de+eted and t,e ,arm3u+meta+( +i"e mercur# +ead and cadmium are increa(ed. Suc, ob(er4ation( o3ten +ead to c,e+ation;t#et,era# :,ic, need( to be done care3u++# :it, reintroduction o3 bene3icia+ minera+ coc"tai+( and "eeing$S* +e4e+( re(er4ed or increa(ing.

F+uoride( tend to be accumu+ated ?integrated@ o4er a +i3etime and t,e (ame net do(e occur( 3rom a ten;unit do(e o4er one #ear or t,at o3 a one unit do(e o4er ten #ear( T,i( ta"en 3rom t,e 'OE( co4eru onCFS F+uoride and it( ma((i4e e33ect on ,uman ,ea+t,6 T*E C*9ONIC FATI$XE SN'9O5E9EPO9T B#6 . E. P,e+( Co#rig,t !00& !00.

*o: t,en to get rid o3 t,i( (courge7 Pame+a 3rom =a(,ington :rite(6

I ,a4e (u33ered :it, Fibrom#a+giaG9o(acea and T5 3or o4er 10 #ear(... 5# 3ir(t (#mtom(aeared (,ort+# a3ter I began ta"ing Pa2i+. A3ter about % mont,( :,en I 3ound t,e Pa2i+ (idee33ect( into+erab+e m# doctor (:itc,ed me to Pro8ac. =e++...:it,in ! #ear( I ,ad gained )ound cou+dnUt get m# temerature to a norma+ %./ ?it :ou+dnUt budge abo4e /./@ bro"e

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out :it, a 3ierce ca(e o3 9o(acea ?("in b+i(tering \ ea+ing in +a#er( o33 m# c,ee"(@ :a(c,ronica++# 3atigued and (u33ered 3rom T5 (#mtom(.

A3ter reading t,e FLXO9I'E in3ormation on Eart,C+inc and re(earc,ing t,e c,emica+3ormu+a( o3 t,e man# antidere((ant( t,at I ,ad ta"en o4er t,e +a(t 10 #ear( I ,ad anei,an#...5# rob+em :a( FLXO9I'E Incidenta++# t,e (#mtom( o3 FLXO9I'ETOICIT are t,e (ame a( Fibrom#a+giaH (o it :a(nt (urri(ing to +earn t,at FLXO9I'E i(

t,e rimar# ingredient in 5AN :ide+# re(cribed antidere((ant( inc+uding PAIL andP9OMAC

=it,out de+a# I began adding 1G% t( o3 BO9A and 1G% t( o3 NATX9AL ?XN;b+eac,ed@SEA SALT to a +iter o3 'E;CLO9INATE' :ater. ?A (imi+r amount in bat, :ater (,ou+d :or":onder(.@ T,i( regimen ju(t ,aen( to bot, neutra+i8e t,e FLXO9I'E and KILL t,e na(t#mite( t,at cau(e 9o(acea. I began drin"ing 1 +iter er da# 3or da#(. On t,e t:o o33 da#( I(im+# dran" uri3ied bott+ed (ring :ater.

T,e re(u+t( :ere not,ing (,ort o3 5I9ACXLOXS :it,in t:o :ee"( m# 3ace c+eared t,eredne(( 3aded and be(t o3 a++ m# temerature norma+i8ed to %./ and m# energ# +e4e+ beganto (teadi+# increa(e. ?'o e2ect t,e brea" out to get :or(e be3ore it get( better a( t,e mite(

die o33.@In ju(t one mont, :it,out dieting or c,anging m# dai+# routine ?ot,er t,an adding BO9A \SEA SALT to m# drin"ing :ater@ I droed & ound( and I continue to dro :eig,t at abouta ound a :ee". I attribute t,i( to m# increa(ed bod# temerature and e+e4ated metabo+i(m.

ALSO...:,en I e+iminated t,e FLXO9I'E in m# toot,a(te m# gum( (toed (:e++ing andb+eeding and a++ P9E


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Lac" o3 iodine cau(e( ac,+or,#dria ?+ac" o3 (tomac, acid@ :,ic, re(u+t( in a ,o(t o3 dige(ti4e rob+em(and e4entua+ rotein de3icienc#.

Bot, organic and inorganic 3+uoride comound( ,a4e been (,o:n to in,ibit 8inc;containing en8#me((uc, a( carbonic an,#dra(e ?'ugad et a+ 1%%1%H $e+b et a+ 1%@ t,at i( not on+# nece((ar# todige(tion but i( no: u(ed a( a mar"er 3or t,#roid d#(3unction ?*ori et a+ 1%@. Minc;deendenten8#me( contro+ t,e re+ea(e o3 4itamin A 3rom t,e +i4erH t,u( t,eir being in,ibited ma# :e++ +ead to a

4itamin A de3icienc# and a arado2 o3 ,eatoto2icit# o3 4itamin A. Anot,er (tud# 3ound t,at +arge ora+(u+ement( o3 4itamin A re(er4ed muco(a+ IgA +e4e+ during rotein ma+nutrition o((ib+# b# (timu+atingT,! c#to"ine roduction and t,ereb# inducing re(i(tance again(t in3ection. F+uoride cau(e( damage to t,e3at in #our bod# ?+iid ero2idation@ :,ic, i( counteracted b# t,e antio2idant( beta;carotene and(uero2ide di(muta(e.

In =i+(on( 'i(ea(e re(earc,er( ,a4e (,o:n t,at a er(i(tent coer to2icit# can o4er+oad and di(ab+e5T rotein(. Coer i( neuroto2ic at +o:er +e4e+( t,an recent+# t,oug,t and it roduce( +arge amount( o33ree radica+(. In rabbit( e2ce(( coer induce( accumu+ation o3 beta am#+oid and (eni+e +aue( t,e,a++mar"( o3 A+8,eimer( 'i(ea(e t,at o3ten a33ect( 'o:n( and o+der auti(tic(. Auto(# o3 Brain( o3A+8,eimer( 4ictim( (,o:( ,a++mar" at,o+ogica+ c,ange( cau(ed b# 3ree;radica+ acti4it# inc+uding 'NAdamage and o2idation o3 rotein( and 3at(. T,e +eading =i+(on( 'i(ea(e t,era# in4o+4e( remo4a+ o3e2ce((i4e coer 3rom +i4er "idne#( and brain 3o++o:ed b# re(toration o3 norma+ 8inc +e4e+(. 'r. =.=a+(, roo(e( t,at t,e (ame treatment ma# be e33ecti4e in treating auti(m. Te(t 3or coer in ta :ater6mi2 ,a+3 a g+a(( o3 :ater :it, a ,a+3;ounce o3 ,ou(e,o+d ammonia ; ;ounce :ou+d be a tab+e(oon. I3 itturn( b+ue #ou need #our :ater te(ted 3urt,er.

E+e4ated (erotonin +e4e+( ,a4e been con(i(tent+# 3ound in -0;0 o3 auti(tic atient( and ma#rere(ent a mar"er 3or 3ami+ia+ auti(m. *#er(erotonemia in auti(m aear( to be due to en,anced ;*T?(erotonin@ uta"e a( 3ree ;*T +e4e+( are norma+ and t,e current reort o3 an e2ce(( o3 t,e +ongG+ong ;*TTLP9 genot#e in auti(m cou+d ro4ide a artia+ mo+ecu+ar e2+anation 3or ,ig, +ate+et (erotonincontent in auti(m;P5I'6 11-)%%&. Serotonin (#nt,e(i( i( decrea(ed in t,e brain( o3 auti(tic c,i+dren andincrea(ed in auti(tic adu+t( re+ati4e to age;matc,ed contro+( ?C,ugani et a+ 1@ :,i+e :,o+e b+ood

(erotonin in +ate+et( i( e+e4ated regard+e(( o3 age ?Lebo#erH Coo" 10@. One (tud# reort( t,at adecrea(e in cortica+ ;*T!A recetor( i( t,e main neuroc,emica+ e4ent under+#ing t,e imairing e33ect o3,#ot,#roidi(m on ;*T neurotran(mi((ion ?Ku+i"o4 et a+ 1@. 'r. =ard 'ean 5' (tate( t,at ;*TPdoe( not rai(e eri,era+ +e4e+( o3 (erotonin a( it i( con4erted to (erotonin in t,e brain. T,i( :ou+d (eemto ro4ide a (o+ution to t,e need 3or en,anced (erotonin in t,e brain( o3 c,i+dren :,i+e re(tricting it in t,eb+ood (tream. Adeuate magne(ium :ou+d re4ent remature de(truction in t,e (#na(e a+(o contributingto increa(ed re(ence in t,e brain.

Lo: brain (erotonin +e4e+( are a((ociated :it, increa(ed (en(iti4it# to ain and c,ronic ain (u33erer(aear to ,a4e reduced (erotonin 3unctioning. Serotonin i( "no:n to ,a4e an e33ect on ain a:arene(( inart b# contro++ing t,e re+ea(e o3 a ain;(igna+ing brain c,emica+ ca++ed Sub(tance P.

9e(earc,er( ,a4e 3ound a mutation in t,e ,uman (erotonin tran(orter gene ,SE9T in unre+ated 3ami+ie(:it, OC'. A (econd 4ariant in t,e (ame gene o3 (ome atient( :it, t,i( mutation (ugge(t( a geneticdoub+e ,itD re(u+ting in greater bioc,emica+ e33ect( and more (e4ere (#mtom(. Inter4ie:( o3 t,eatient( 3ami+ie( re4ea+ed t,at / o3 t,e ) indi4idua+( :it, t,e mutation ,ad OC' or OC er(ona+it#di(order and (ome a+(o ,ad anore2ia ner4o(a A(erger( (#ndrome (ocia+ ,obia tic di(order anda+co,o+ or ot,er (ub(tance abu(eGdeendence.

T,e combination o3 t,e(e c,ange( bot, o3 :,ic, increa(e (erotonin tran(ort ma# e2+ain t,e unu(ua+(e4erit# and treatment re(i(tance o3 t,e i++ne((e( in t,e (ubject( and t,eir (ib+ing(. T,i( i( robab+# t,e

&1


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3ir(t reort o3 a modi3ication in a tran(orter gene re(u+ting in a gain rat,er t,an a decrea(e in 3unctionD(aid NI5* 'irector T,oma( In(e+ 5.'.

SE9T a++o:( neuron( +ate+et( and ot,er ce++( to accumu+ate t,e c,emica+ neurotran(mitter (erotonin:,ic, a33ect( emotion( and dri4e(. Neuron( communicate b# u(ing c,emica+ me((enger( +i"e (erotoninand doamine bet:een ce++(. T,e tran(orter rotein b# rec#c+ing (erotonin bac" into t,e neuronregu+ate( it( concentration in a ga or (#na(e and t,u( it( e33ect on a recei4ing neuron( recetor. T,i(

mutation remo4e( a4ai+ab+e (erotonin 3rom t,e (#na(e ,a4ing t,e e33ect o3 a (erotonin de3icienc#.

Tran(orter( are imortant (ite( 3or agent( t,at treat (#c,iatric di(order(. 'rug( t,at reduce t,e bindingo3 (erotonin to tran(orter( ?(e+ecti4e (erotonin reuta"e in,ibitor( or SS9I(@ are u(ed ?:it, aarentinitia+ (ucce((@ to treat menta+ di(order(. T,i( re4ent( norma+ reuta"e into +ate+et( and ot,er ce++( ?a(:e++ a( into neuron(@ and a( a re(u+t cou+d contribute to b+eeding a( a certain +e4e+ o3 (erotonin i(needed 3or +ate+et( to aggregate norma++# in contro++ing b+eeding. T,i( re4iou(+# unreorted in3ormationindicate( t,at SS9I( are a++ t,e more dangerou( :,en ta"en :it, coumadin NSAI'( or a(irin ?% 3o+dri("@. Combining NSAI'( a(irin and and SS9I( increa(e ri(" to !%;3o+d T,e (tud#

Mastering+Autism

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