Linfoma de Hodgkin Médula ósea
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Luis Humberto Cruz Contreras
Residente de anatomía patológica
Hospital General «Miguel Silva»
Linfoma de HodgkinMédula ósea
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Neoplasia clonal de cél. B de los centros
germinales.
2.7 por 100 000 EUA
2 picos de Inc.
Adultos jóvenes
40-45a
Introducción
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Subclasificación
60 a 70%
*Entidad clínica diferente, más parecida a LNH
30 %
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Linfadenopatia
+ Frec. Ganglios cervicales
G Mediastínicos, Hepatoesplenomegalia
Síntomas B
Clínica
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Diseminación por cadena ganglionar
Prurito
Dolor post etílico
Clínica
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EstadificaciónInvasión MO 5-15% de pac.NO es posible subclasificar LH
Evaluación MO
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>35a WBC <6,000 mm3
Ganglios inguinales
Síntomas B
Estadio III o IV
Prob. Infiltración MO
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Grande Citoplasma eosinófilo
Nucleólo prominente eosinófilo
Binucleada
Variantes
Célula Reed-Sternberg
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CD45- CD 15+
CD 30+
Célula Reed-Sternberg
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Cél. Reed-Sternberg Fibrosis
Dx en Biopsias / NO en aspirado
Dx Infiltración MO
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MO con áreas fibrosas focales características en LH
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Lás áreas fibrosas deben contener cél. Reed-Stenberg
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Variedad de esclerosis nodular con cél. Reed-Sternberg, linfocitos, y eosinófilos
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Cél. De RS en Variedad de Esclerosis nodular clásico
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Cél. Lacunar (izq) Cel. RS mononucleares (der)
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Tratamiento
Enfermedad localizada : 90% Curación
Qt inicial
Rt En ganglios afectados