Legame cometitivo al DNA Mascheramento della superficie di attivazione Interazione con Fattori...
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Transcript of Legame cometitivo al DNA Mascheramento della superficie di attivazione Interazione con Fattori...
Legame cometitivo al DNA
Mascheramento della superficie di attivazione
Interazione con Fattori generali della trascrizione
Reclutamento di complessi di rimodellamento della cromatina repressivi
Reclutamento di istone deacetilasi
HELICASE/ATPase domain
BROMO domainbinds acetylated lysines on histone tails
HSA domain protein interactions
actin/ARP transcription factors
ATPase domain
ROLE of SNF2/BRM domains
SNF2 ATPase activitychange nucleosome positionincreased regulatory protein access!change nucleosome conformationeject histone octamer
displace H2A/H2B dimer
Roles of SWI2/SNF2Role in activation or repression of genesInducible gene expression:transcription initiationtranscription elongation
SplicingRepair
Roles of ISWInucleosome array formationchromatin assembly, replication
heterochromatin formationtranscriptional regulation some PolII, PolI
SANT/HAND domain contacts histone tails
Slide domain linker DNA contact, ’measures’ distanceequal spacing of nucleosomes
ATPase domain
ROLE of ISWI domains
CHD ATPasesCHD1: role in chromatin assembly; open chromatinin pluripotent cellsNuRD complex also contains Me-DNA binding protein (MBD2)complex connects deacetylation, chromatin remodeling and DNA methylation; repressive function
CHROMO and PHD domainsbind methylated lysines on histone tailsmodulate activity of remodelers
ATPase domain
ROLE of CHD ATPase domains
INO80chromatin assemblyDNA repairinteracts with phosphorylated H2A.X (gammaH2A.X)transcription
SWR1H2A exchange with H2A.ZBoundary to heterochromatin spreadingtranscriptionally poised promoters (together with H3.3)
WINAC-WICHWSTF Williams syndrome transcription factor
helix–turn–helix motif (HTH)
tight chromatin binding
stepwise assembly model for transcription initiation.