Lap Du an Xay Dung Nha May Hoa Duoc Tri Ung Thu Tu Duoc Lieu Viet Nam

Phng n tin kh thi: XY DNG NH MY HA DC PHM TR UNG TH T DC LIU VIT NAM.

Phn I: NH HNG U T, IU KIN THUN LI V KH KHN

I. GII THIU V D N U T:

a ch nh my:

Tr s:

in thoi:

i din bi:

Chc v:

Email:

II. CN C PHP L XY DNG D N:

1. Quyt nh s 61/2007/Q-TTg ngy 7/5/2007 ca Th tng Chnh ph v ph duyt Chng trnh nghin cu khoa hc cng ngh trng im quc gia v pht trin cng nghip ha dc n nm 2020, c tnh n nm 2030 (sau y gi tt l Chng trnh Ha dc). Mc tiu chung ca Quyt nh 61 nu trn bao gm vic nghin cu khai thc v s dng c hiu qu cc hot ng cht thin nhin v xut khu.

Mc tiu c th ca Chng trnh Ha dc theo Quyt nh 61 l nhm gp phn xy dng v pht trin ngnh cng nghip ha dc Vit Nam.

Cc nhim v ch yu ca Chng trnh Ha dcgm c:

- To vng nguyn liu cy Da cn lm nguyn liu sn xut thuc iu tr bnh ung th.

- Nghin cu hon thin v thng mi ha cng ngh sn xut cc hot cht thin nhin sn xut thuc trong nc.

2. Quyt nh s43/2007/Q-TTg ngy 29 thng 3 nm 2007 ca Th tng Chnh phv ph duyt n v pht trin cng nghip dc v xy dng m hnh h thng cung ng thuc ca Vit Nam giai on 2007 -2015 v tm nhn n nm 2020.

Theo Quyt nh s 43 n nm 2020 s u t mi xy dng mt s nh my sn xut nguyn liu khng sinh th h mi c bit xy dng cc nh my sn xut nguyn liu thuc ung th, ni tit, tim mch v cc nh my chit xut dc liu, tng hp, bn tng hp.

3. Cc c s php l khc:

- Ngh quyt s46 - NQ/TW ngy 23/02/2005 ca B Chnh tr BCH TW v cng tc bo v, c s v nng cao sc khe nhn dn trong tnh hnh mi.

Ngh nh s210/2013/N-CP ngy 19/12/2013: Khuyn khch doanh nghip u t vo nng nghip nng thn.

Quyt nh s 68/2013/Q-TTg ngy 14/11/2013 v chnh sch h tr gim tn tht trong nng nghip.

- Ngh nh s 55/2015/N-CP ngy 9/6/2015 v chnh sch tn dng phc v pht trin nng nghip, nng thn.

- Cc thng t, vn bn di lut ca cc B: K hoch v u t, Ti chnh, Y t.

III. TN D N V NI DUNG U T:

1. Tn d n: u t xy dng nh my sn xut ha dc cha ung th t dc liu Vit Nam.

2. nh hng u t:

2.1 Ni dung u t:

+ u t xy dng nh my sn xut ha dc cha ung th t cc dc liu Vit Nam (V d:Thng , da cn, ngh, hoa he ).

+ u t xy dng xng bo ch thuc ung th thay th thuc nhp khu.

+ Xy dng vng trng dc liu (Thng , Da cn, Ngh, Hoa he v cc dc liu cha ung th khc) cung ng cho nh my.

+ u t xy dng phng th nghim qui m PILOT nghin cu hon thin qui trnh sn xut, qui trnh bo ch thuc ung th v mt s cc sn phm t hot cht thin nhin (phng th nghim R&D).

2.2 Mc tiu chung:

+ Gp phn pht trin tim nng dc liu Vit Nam, xy dng ngnh dc Vit Nam thnh ngnh kinh t - k thut mi nhn (Ngh quyt s 46-NQ/TW ngy 23/02/2005 ca B Chnh tr).

+ Gp phn lm gim gi cc loi thuc ung th nhp khu.

2.3 Mc tiu c th:

2.3.1 Sn xut ha dc cho thuc ung th.

Cc sn phm t cy Thng : 5kg/nm.

Cc sn phm t cy Da cn: 5kg/nm.

Quercetin/Rutin: 20 tn/nm.

Curcumin: 20 tn/nm.

Tetrodotoxin: 1kg/nm.

+ Bo ch thnh phm thuc ung th bo m cho nhu cu cha bnh trong nc t sn xut 06 loi sn phm ch yu:

a. Paclitaxel 100mg/l.

b. Docetaxel 20mg/l.

c. Vinplastin 10mg/amp.

d. Vincristin 1mg/amp.

e. Vinorelbin 50mg/l.

f. Vinorelbin 20mg/vin.

g. Curcumin 1g/Tab.

h. Quercetin 0,5g/Caps.

i. Tetrodotoxin 0,2mg/Caps.

2.3.2 Xy dng vng nguyn liu (nui + trng dc liu) 250 ha: m bo cung ng dc liu cho nh my ha dc.

a. Vng trng Thng : 20 ha.

b. Vng trng Da cn: 20ha.

c. Vng Hoa he: 100ha.

d. Ngh: 20ha.

e. Dc liu khc (gc, bn chi lin, bn bin lin.): 90 ha.

2.3.3 Xy dng Phng th nghim R&D (PTN R&D) nghin cu: Chit tch, bn tng hp; bo ch thuc ung th v h tr iu tr ung th t cc dc liu khc ca Vit Nam.

+ Nhim v ca Phng th nghim R&D: i) Nghin cu chit, tch, bn tng hp cc hp cht thin nhin lm thuc; ii) Nghin cu bo ch.

+ Mc tiu c th ca Phng th nghim R&D:

a) V ha dc: Nghin cu hon thin cng ngh chit tch sn phm cha Vim gan C v ung th gan t cy h Sophora (Matrine) v Fucoidan (t rong nu ca Vit Nam) (hp tc vi Vin Nghin cu Bin Nha Trang); Nghin cu chit Lumbritin t giun t; Nghin cu hon thin cng ngh chit tch Tetraodotoxin t c nc; Nghin cu chit tch nc b cp (Ratsutoxin); Sn xut Morphin, Codein t cy thuc phin, t cy Gai mo sn xut Delta9-THC (nu c Chnh ph cho php); Nghin cu ch phm Nm Vn Chi, Nm Lim Xanh: Cha ung th gan; Nghin cu sn xut Matrine tr vim gan C v ung th gan,

b) V bo ch cng ngh cao: Nghin cu cc cng ngh Nan,Liposome, Microcapsul; S dng cc cht mang dn thuc n cc t bo b bnh (Dimethylsulfoxid, Carboxymetyl Chitosan).

c) Nghin cu hon thin cng ngh bo ch v cng ngh chit, tch, bn tng hpphc v cho qu trnh sn xut.

3. S cn thit phi u t; Cc cn c ch yu xc nh phi u t:

3.1 Tnh hnh mc bnh ung th v cht v ung th Vit Nam (theo s liu ca Hi ung th):

- T l mc mi trung bnh hng nm: 200.000 ngi/nm (nm 2010: 216.300 ngi).

- S ngi cht trung bnh/nm: 75.000 ngi/nm (ton th gii 14 triu ngi cht/nm, l bnh c t l cht cao nht trong 11 loi bnh).

- Ngi mc bnh ung th: Hong lon v tinh thn, au n v th xc, khnh kit v kinh t.

- S ngi phi iu tr hng nm: Khong 1,5 n 2 triu ngi.

- S tin thuc iu tr, c tnh khong 10.000 t ng (theo s liu u thu thuc).

3.2 Cc phng php cha tr ung th,

- Phu thut: Ct b cc b phn b ung th.

- Ha tr liu: Dng thuc v ha cht tiu dit t bo ung th.

-X tr: Dng tia phng x dit t bo ung th hoc km hm s pht trin

ca t bo ung th.

-Min dch tr liu: Lm tng cng kh nng min dch chng li t bo ung

th (CIC/Comdined immunotherapy For cancer);Chin lc ca CIC trong nghin

cu Vaccine; B sung thuc y hc c truyn v phn ln cc bnh nhn ung th iu

yu t, v, kh (chc nng lu chuyn ca c th),

3.3 Phn loi thuc ung th:

Thuc cha ung th phn loi theo m ACT m gii phu quc t ha (K hiu L trong dc th quc gia Vit Nam v cc dc in nc ngoi).

C 04 nhm: L01; L02; L03; L04

- C th v 04 nhm thuc (L01; L02; L03; L04) nh sau:

a) Nhm L01: L cc cht chng ung th kim ch t bo: Nhm ny c

xem l thuc ha tr tc dng l ngn cn khng cho cc t bo ung th sinh, cn tr

qu trnh pht trin ca ADN v ARN, tc dng ln cc Enzyme tham gia vo qu

trnh sao chp AND, lm chm qu trnh pht trin t bo ung th, hoc tiu dit t bo

ung th,

b) Nhm L02 liu php ni tit t: Cng c xem l thuc ha tr gm cc

cht Corticoide l nhng hormon t nhin v ging hormon dng tiu dit cc t

bo ung th, hoc lm chm qu trnh pht trin ca chng,

c) Nhm L03: Nhm cc loi thuc kch thch min dch hin nay trn th

gii pht trin c nhiu loi Vaccin nga ung th, (V phn ln cc loi ung th

khng phi do virus gy ra), V vy, xu th nghin cu thuc ung th l kch thch

phn ng min dch t nhin ca con ngi tn cng bnh ung th khi chng xut

hin trong c th,

(V phn loi: Nhm ny khng thuc nhm Thuc Ha Tr, nhng thng kt hp vi nhm ha tr cha ung th),

kch thch min dch thuc thuc nhm ny s dng 02 loi min dch liu php khc nhau:

- Min dch liu php ch ng (Kch thch h min dch ca c th

cha bnh ung th) v

- Min dch liu php th ng cn gi l: Liu php khng th n dng

(L vic s dng nhng thnh phn ca h min dch (V d nh: Khng th), c

to ra Labo a vo c th),

d) Nhm L04: Cc tc nhn c ch min dch,

Tc dng ch yu l c ch min dch, cn tr hoc chng chuyn ha t bo, c ch tng hp DNA, RNA v Protein,

c th hiu khi qut chung v thuc cha ung th chng ti gii thiu bng 1 (di y) l bng danh mc thuc cha ung th theo m ACT trong dc th quc gia Vit Nam,

3.4 Tnh hnh sn xut v cung ng thuc ung th Vit Nam:

- Ha dc: 100% nhp khu t nc ngoi.

- Cc c s sn xut trong nc:Cho ti nay Vit Nam mi c 2 nh my bt u u t nghin cu bo ch, nhng cha c nh my sn xut thuc t tiu chun bo ch thuc ung th.

3.5 Gi bn thuc ung th trn th trng: Cao v khng kim sot c; nu sn xut trong ncth d kin gi bn ch bng 50% gi nhp khu (t cc nc thuc khi G7). S liu tng hp thuc iu tr ung th v min dch ch yu nhp khu v tiu th 2012 Thuc iu tr ung th (theo m phn loi ti dc th quc gia Vit Nam) l 2,600 t VN (lm trn s) gm: (Xem ph lc Danh mc thuc iu tr ung th v min dch ch yu nhp khu v tiu th 2012)

- LO1: 1,208,7 t, - LO2: 202,2 t, - LO3: 215,78 t, - LO4: 511,21 (nhm ny trn thc t ln hn nhiu v khng c trong

danh mc thu, nn khng thng k c), - Nhm khc: 91,45 t (V d: Vaccine),

Nhm thuc chng au v gim nh: 500 t,

Cc loi thuc h tr (ng y, YHCT): 1,500 t,

Ha cht khc: 500 t,

Tng cng: Khong 5,100 t VN n 6,000 t VN (chim 10-12% th phn thuc cha bnh Vit Nam).

3.6 S ngi mc bnh ung th Vit Nam c kh nng tip cn vi thuc cha v dch v ca bnh vin cng: Ch khong 30% (con s ny: c tnh da vo s tin thuc tiu th ca bnh vin, v s ging bnh ca cc bnh, khoa ung bu ca c nc 2012, 2013) (theo webcancer.iaea.org: Th trng B Y t Nguyn Th Xuyn: Vit Nam mi p ng 10% yu cu phng chng ung th).

3.7 Ngnh dc Vit Nam t lu ph thuc vo nc ngoi, trn 90% nguyn liu ha dc phi nhp khu, khin cho gi thuc lun bt n.

4. iu kin thun li, nu u t vo d n ny:

4.1 Th trng thuc ung th ca Vit Nam nhu cu tng 0,5 n 2 ln trong 5 nm ti, c bit l cc thuc phng chng ung bu.

- T l ngi mc ung th ca Vit Nam c xu hng gia tng.

- T l ngi c tip cn thuc ung th s gia tng cao nu chnh sch bo him ton dn, gi thuc ung th gim do sn xut c trong nc (hin ti ch khong 30%)

4.2 Tm tt v nng lc khoa hc cng ngh l t chc v c nhn s tham gia d n.

Bng 1: Gii thiu nng lc khoa hc cng ngh ca cc t chc v n v

tham gia d n

STT n v tham gia d n

Nng lc, kinh nghim

(1) (2)

I Cc nh u t:

1 Cng ty C phn Y Dc phm VIMEDIMEX

4 L mt trong cc doanh nghip phn phi dc phm ln nht Vit Nam (TOP 500 doanh nghip ln nht Vit Nam) doanh thu v dc phm trung bnh 3 nm 2010, 2011, 2012: 5.000 t VN; trong c 700 t cc sn phm ung th v h tr iu tr ung th

5 thc hin (v a vo ng dng):

6 ti, d n cp nh nc

5 ti, d n cp b

10 ti, d n cp c s 6 Hin Cng ty Vimedimex ang cng Cng ty C phn BV Pharma

u t cho d n sn xut th nghim cp nh nc:

Trng 10 ha Thng

Sn xut Paclitaxel qui m Pilot

Sn xut Paclitaxel tim truyn.

2 Cng ty C phn BV Pharma

7 L Cng ty lin doanh vi nc ngoi chuyn nghin cu v trng v ch bin cy thuc (Thuc B Nng nghip Cng ha Lin bang Nga)

8 L Cng ty hng u ca Vit Nam trong lnh vc: Sn xut nguyn liu lm thuc v thc phm chc nng; vi cc sn phm ch yu (n 2011)

Cao kh dc liu: 200tn/nm

Ha dc t dc liu: Mangiferin (TCDDVN4) Curcumin; Rutin DAB8; Chitosan; glucosanin sulfat.

Vi cc dng sn phm c bit:

Bt sy phun sng (cao kh dc liu)

Bt ng kh (sa ong cha, phn hoa ) 9 BV Pharma ang ch tr ti nh nc sn xut th nghim

Paclitaxel, 10DABIII, thuc tim Paclitaxel, sn xut du gc cht lng cao (Beta-Caroten 0,200mg%, 0,100mg% lycopene).

10 Quan h i ngoi: BV Pharma, Vimedimex ang xy dng chng trnh hp tc u t sn xut Ha dc v sn xut thuc ung th ti Vit Nam vi cc Cng ty c, Nht, Trung Quc, Nga.

3 Cng ty CP

SXCBNLS Dc liu sch k Nng.

11 C i ng cn b khoa hc k thut c kinh nghim trin khai cc d n ln v sn xut nng, lm sn, dc liu

12 C t trin khai d n 13 C c s vt cht k thut tham gia sn xut ging, ch

bin dc liu.

(1) (2)

I

I

Cc n v tham gia ng gp v nghin cu v khoa hc-cng ngh

1

Trung tm ung bu Bnh vin 19.8 (B Cng An)

C i ng cc nh khoa hc trong lnh vc ung th v chng au trong ung th. Tham gia trong d n ch tr phn:

14 nh gi sinh kh dng, tng ng sinh hc

2 i hc Y Dc TP. HCM

15 L c s o to cn b Y dc i hc v trn i hc ln ca c nc

16 L c s nghin cu khoa hc: Tham gia gii quyt cc vn cng ngh trong sn xut v bo ch; tiu chun ha

3 i hc Bch khoa TP.HCM

17 Mt trong cc trung tm ln ca c nc o to cn b cho ngnh cng ngh ha dc.

18 T vn hoc tham gia thit k dy truyn cng ngh sn xut 19 Tham gia gii quyt cc vn cng ngh chit tch bn

tng hp cng vi cc nh khoa hc

4 i hc Khoa hc t nhin TPHCM

5 Khoa Ha, i hc khoa hc t nhin H Ni

6 i hc Nng Lm TP.HCM

20 L trung tm o to ln ca c nc, o to v nghin cu khoa hc trong lnh vc: Nui-trng dc liu

7 Trung tm Sm v

Dc liu TP.HCM 21 n v nghin cu hng u pha Nam trong lnh vc iu

tra dc liu; nghin cu trng v pht trin dc liu 22 Nghin cu tc dng ca Dc liu 23 Xy dng tiu chun dc liu

8 Vin Ha hc Cng nghip (Tp on Ha cht VN, B Cng Thng)

24 L Vin nghin cu chuyn ngnh ha 25 L n v nghin cu khoa hc - ng dng ln ca c nc,

ch tr nghin cu nhiu ti, d n ca nh nc.

9 Vin Ha hc (Vin

Hn lm Khoa hc Vit Nam)

4.3 Nhn lc khoa hc cng ngh:

Bng 2: Danh sch cc nh khoa hc v nh cng ngh tham gia d n

STT H tn v chc danh khoa hc Phm vi tham gia

1 DS. Ths. Nguyn Tin Hng Ch nhim d n

2 TS. Trn Ch Lim Ph ch nhim d n

3 TS. Vng Ch Hng Ph ch nhim d n

4 PGS. TS. Trn Cng Lun Ch tr v nghin cu chit tch Palitaxel, Docetaxel

5 TS. Trn Bch Dng Ch tr nghin cu chit tch alcaloide t da cn

6 PGS. TS. Phm Ngc Bng Ch tr nghin cu v Bo ch: Cc sn phm chung.

7 PGS. TS. L Minh Tr Ch tr nghin cu v Bo ch tim: Paclitaxel, Docetaxel, Vinplastin, Vincristin, Navelbin

8 GS. Hong Xun Ba Ch tr: Hp tc quc t v nh gi sinh kh dng

9 TS. Trn Quc Hng Ch tr: nh gi lm sngv tng ng sinh hc

10 TS. H Hi Th k d n

11 DS. o Ngc Quynh Thnh vin d n

12 DS. Trn Vn o Thnh vin d n

13 Nguyn Quc Dng MBA Thnh vin d n

14 PGS. TS. Hunh Thanh Hng Thnh vin d n

15 PGS. TS. Hunh Thnh o Thnh vin d n

4.4 Vt lc:t (phc v cho d n, cc doanh nghip c th gp ti sn cho d n):

Bng 3: Danh sch cc n v tham gia gp vn (t) cho d n

STT Tn cng ty, n v Ni dung gp vn Tr gi gp vn

1 Cng ty VIMEDIMEX t lm vn bo tn v vn ging dc liu: 10ha ( Lt)

10 t VN

2 Cng ty BVPHARMA t xy dng phng th nghim trng im 0,2ha (C Chi TP. HCM)

6 t VN

3 Cng ty k Nng APM

(ti k Nng) 1. Vn nghin cu v sn xut ging 2. t xy dng nh my.

0,8 t VN

4 t VN

Cng: 160 t VN

Bng 4: Danh sch cc n v tham gia gp vn bng nh xng

v my mc thit b cho d n

STT n v gp vn Ti sn gp vn qui ra tin Tr ga tin gp vn

1 Cng ty c phn tp on dc phm Vimedimex

1. Ton b nh, Xng t GMP - WHO. 2. Trang thit b R&D & KTCL t GLP. 3. Trang thit b v dng c ca hai phn xng

thuc rn phn liu. 4. Kho 1.000m2 t GSP. 5. Vn phng lm vic v c s h tng. 6. Nh cho R&D & kim tra cht lng.

u t mi 100%.

Tr gi: 140 t VN.

2 Cng ty CP BV Pharma 1. Dy chuyn ng b sn xut dch truyn v dung mi t GMP.

u t mi 100%

22 t VN

Cng: 162 t VN

Bng 5: Danh sch cc phng th nghim ca cc vin, trng

tham gia vo thc hin d n

STT Tn cng ty, n v Ni dung hp tc

1 Vin Ha hc cng nghip Vit Nam 1. Pilot nghin cu chit tch bn tng hp

2. Labo R&D

3. Phng th nghim kim tra cht lng

4. Vn n, vn th nghim

5. Nhn lc ca cc n v

2 Khoa Ha, i hc Khoa hc t nhin (TPHCM)

3 i hc Bch khoa TPHCM

4 i hc Y Dc TPHCM (Khoa Dc)

5 i hc Nng lm TPHCM

6 i hc Khoa hc t nhin (H Ni)

4.5 Cc i tc ca doanh nghip hp tc h tr doanh nghip trong thc hin d n: Cc khch hng, cc nh u t nc ngoi:

- Cng ty BV Pharma c i tc l Vin Vilar (Vin nghin cu cy thuc thuc Cng ha lin bang Nga).

- Cng ty Vimedimex: L mt doanh nghip thng mi hng u,chim khong 22% th phn dc phm ca Vit Nam, c cc i tc l cc nh sn xut thuc ung th hng u nh:SOGES (CHLB Nga); BMS (M); Roche (Thy S); Ebewe; Pierre Fabre: Php; Aqvida (c); Pharmex; Nagase (Nht); Cisen, Hengrui (Trung Quc); Belmedpreparaty (Belarus).

Cc cng ty trn l cc i tc tim nng, s tham gia d n theo cc hnh thc Businese co-operation contracts; Toll Manufactoring, Joint Venture v l lc lng quan trng thc y s pht trin ca sn phm v thc hin vic chuyn mn ha sn xut.

5. Kh khn v h qu:

5.1 Kh khn:

+ u t nh my sn xut ha dc tr ung th l u t ln v lu di, tng vn u t cao nhiu ln so vi u t vo nh my sn xut thuc thng thng.

+ V sn xut ha dc chng ta phi cnh tranh vi cc tpon ln v cng ngh v vi cc cng quc v ha dc (n , Trung Quc, c, Ty Ban Nha, M ). Mc d c li th, nhng khng th trnh khi nhng kh khn ban u.Hiu qu kinh t - k thut c th khng cao.C th gi bn bng nhau, sn xut ha dc khng c li trong sn xut (nhng nm u).

+ Xy dng vng trng dc liu tp trung: Chi ph n b gii phng mt bng cao, mua li t ca dn v doanh nghip cao, nu khng c s h tr ca nh nc th rt kh thc hin (c bit l i vi vng trng Thng ).

5.2 H qu (c th):

+ Vic tiu th (gi thit cht lng ngang bng vi cc nc tin tin) th cng l vic kh khn, c th kh khn hn c vic u t v p dng cng ngh.

+ Tht bi tm thi do thiu k nng v kinh nghim do ch quan ca con ngi.

Hai vn trn s c trnh by c th phn Kt lun v Kin ngh.

Phn II: QUY M D N V HNH THC U T

I. QUY M.

1. Nh my sn xut ha dc: 20.000m2

Bng 6: Hng mc u t nh my ha dc

VT: T ng

STT Hng mc Vn u t Hnh thc u t

1 Phn xng chit tch 81.5 Mi 100%

2 Phn xng bn tng hp 17 Mi 100%

3 Phn xng tinh ch 19 Mi 100%

4 Phn xng nghin cu v pht trin

60 Mi 100%

5 Xy dng 47 Mi 100%

TNG 224.5

2. T chc sn xut theo hp ng hp tc kinh doanh(BCC-Busines

Co-operation Contract)

Bng 7: Hng mc u t nh my bo ch dc phm

VT: T ng

STT Hng mc Vn u t Hnh thc u t

1 My thit b cho sn xut thuc tim

145 Hp tc BV Pharma v Vimedimex

2

My thit b cho sn xut thuc rn phn liu v dung mi


3 My thit b cho b phn R&D bo ch


4 Xy dng 76 Hp tc BV Pharma v Vimedimex

5 Dy truyn sn xut dung mi v dch truyn


TNG 305

3. u t cho nui trng cy dc liu ( vng nguyn liu):

Cng ty t t chc sn xut 20 ha vhp ng vi h nng dn sn xut 230 ha

II. TRCH NHIM CA CC BN THAM GIA U T THEO PHNG THC HP NG HP TC KINH DOANH (BCC)

Bng 8: Phn cng trch nhim v quyn li ca cc bn tham gia u t

u t Qun tr Phn chia l - li

Trch nhim ca d n Trch nhim i tc

u t mi my, thit b cho sn xut (mt dy truyn hon thin).

u t: B sung cho i tc:Thit b nghin cu chuyn dng; Thit b kim tra cht lng.

Xy dng nh xng.

Cung cp cc dch v ph tr (hi, kh, cp thot nc, in, in lnh ).

Cung cp dch v: Kho, bi, hnh chnh,

qun tr bo v, vn phng

Khng hnh thnh

php nhn mi (l mt n v thuc i tc qun tr).

Thnh lp mt b phn kinh doanh ring ca BCC hch ton ph thuc.

Ngi ng u ca cc bn BCC s lnh o BCC theo qui nh.

L, li ca cc bn trong BCC khng nh hng n kt qu sn xut kinh doanh ca n v.

L: Phn chia theo t l gp vn trong BCC

Li: Phn chia theo t l gp vn trong BCC.

III. NI DUNG, PHNG THC U T CHO H SN XUT, DOANH NGHIP SN XUT NNG NGHIP THEO PHNG THC: Hp ng lin kt nui trng ch bin tiu th (Hp ng theo m hnh li ch ton chui).

Bng 9: Quyn li, trch nhim ca cc bn tham gia hp ng

Trch nhim nh u t Trch nhim h sn xut theo hp ng

Li ch ca nh u t, h sn xut

Lp k hoch sn xut k hp ng.

Cung cp qui trnh sn xut.

o to, hng dn sn xut theo qui trnh.

Cung cp ging.

H tr ti chnh theo hp ng.

Qun tr sn xut theo GAPC.

Kim sot vic thc hn.

Thu mua.

Ch bin.

t ai, cng c, phng tin sn xut.

Lao ng v lao ng c o to v GAPC.

Vt t, phn bn chm sc bo v thc vt.

Ghi chp hng dn, yu cu qun tr, bo co.

Chm sc.

Thu hoch.

Chu s kim sot theo GAPC.

Nh u t:

Ch ng cho k hoch sn xut ca nh u t.

Khng chu ri ro do bin ng gi c khi mt cn i cung cu.

An ton v cht lng.

H sn xut:

An ton u t.

Thu nhp n nh v ch ng.

c bo lnh, ri ro v gi.

Bo him thin tai, ri ro (nu mua bo him).

c bo him y t (nu c tha thun).

Hng phc li.

IV. HNH THC U T V PHNG THC QUN L:

Hnh thc u t: u t mi nhng mng ha dc v kt hp vi u t theo hp ng hp tc cc phn xng bo ch.

Phng thc qun l:

M hnh qun l: Thnh lp cng ty c phn theo lut doanh nghip. Tn gi: Cng ty C phn Ha dc phm cc sn phm cha ung th (D kin).

S t chc:

26 Cc cng ty nc ngoi

27 Cc cng ty Vit Nam

28 Cc h, n v: SX nng nghip

29 Cc phng nghip v

30 Cc xng sn xut, bo

ch

31 n v nghin cu c lp

32 Cng ty phn phi

33 Cng ty Marketing

Phn III: A IM XY DNG

I. THNG TIN CHUNG V HUYN K GLONG

1. V tr xy dng

D n u t nh my sn xut ha dc cha ung th t dc liu Vit Namc xy dng tix kha, huyn k GLong, tnh k Nng

V tr a l: k Glong nm pha ng Nam ca tnh k Nng cch trung tm th x Gia Ngha 11km trn ng i x Qung Sn, c tng din tch t nhin l 144.875,46 ha, gip vi cc huyn Lk - tnh k Lk pha ng Bc, am Rng pha ng, Lm H pha ng Nam, Di Linh v Bo Lm pha Nam, k R'lp v huynGia Ngha pha Ty Nam, k Song pha Ty v Krng N pha Bc.

Mi quan h vng: k GLong c v tr quan trng c v kinh t, chnh tr v an ninh - quc phng, l ca ng pha ng Nam ni Lm ng vi k Nng v cc tnh Ty Nguyn, trn a bn huyn c Quc l 28 i qua to iu kin thun li cho

Ban iu hnh

Cc V trc thuc

Cc cng ty lin kt Cc cng ty con

vic lu thng hng ho, m ra mt mi thng thng quan trng cho vic pht trin kinh t ca k Glong v tnh k Nng.

2. c im v kinh t- x hi

- Din tch: k GLong c tng din tch t nhin l 144.875,46 ha.

- Dn s: Tng dn s trn a bn huyn l 43.072 ngi.

- Dn tc: Trn a bn huyn c 24 dn tc, bao gm: Kinh; MNng; Nng; Ty; Thi; Dao; M; ; Mng; Hoa; Mng; Sn Chay; Sn Du; Kh Me; XTing; Hre; Co; K Ho; Th; Chu Ru; Giy; X ng; Ch Ro; Chm.

- Tn gio: Trn a bn huyn c 03 tn gio chnh, bao gm: o Cng gio; Pht gio; Tin lnh

L mt huyn mi thnh lp vi im xut pht ban u rt thp, k G'Long phi i din vi nhiu kh khn: hu ht cc x trong huyn l vng 3, vng 2, giao thng i li kh khn, c s h tng gn nh cha c g ng k; tr s lm vic v ni sinh hot ca cc cp chnh quyn, ban, ngnh trong thi gian u hu ht phi thu, mn tm b... Thi gian gn y tc tng trng kinh t hng nm t t 15 n 20%. C cu kinh t chuyn dch theo hng tch cc, t trng nng - lm nghip gim, cng nghip - tiu th cng nghip, thng mi - dch v tng.

3. a hnh

a dng v phong ph, c s xen k l cc thung lng; cao trung bnh trn 800 m. y l khu vc c t bazan l ch yu, rt thch hp vi pht trin cy cng nghip lu nm nh c ph, cao su, iu, tiu v chn nui gia sc, gia cm.

4. Kh hu

k GLong va mang tnh cht kh hu cao nguyn nhit i m, va chu nh hng ca gi ma Ty Nam kh nng. Kh hu c 2 ma r rt: ma ma v ma kh. Ma ma bt u t thng 4 n ht thng 11, tp trung 90% lng ma hng nm. Ma kh t thng 11 n thng 4 nm sau, lng ma khng ng k.

Nhit trung bnh nm khong t 21-220C, nhit cao nht 330C, nhit thp nht 140C, thng nng nht l thng 4, thng lnh nht vo thng 12. Lng ma trung bnh nm khong 2200-2400 mm, lng ma cao nht 3000mm. Thng ma nhiu nht vo thng 8, 9; ma t nht vo thng 1, 2. m khng kh trung bnh 84%. bc hi ma kh 14,6-15,7mm/ngy, ma ma 1,5-1,7 mm/ngy.

5. H tng khu t xy dng d n

5.1. Hin trng s dng t

a. Ti nguyn t:

Mc d l vng c nhiu i ni, nhng k GLong nm trong vng trung tm t bazan, to ra ph nhiu cao trong t, lm cho cy trng pht trin ht sc thun li, thch hp vi cy cng nghip v cy ly g.

Tng din tch t nng nghip trn a bn l 16.673 ha, chim 11,56% ch yu ph hp trng cy cng nghip di ngy nh c ph v cao su v cc loi cy cng nghip khc, to iu kin thun li cho vic pht trin vng cc chuyn canh cy cng nghip sau ny.

b. Ti nguyn rng

Ti nguyn thin nhin ln nht ca huyn l rng t nhin, vi din tch 125.793,2 ha, che ph 65%, ch yu l kiu rng khp kn trong c nhiu loi g qu nh cm lai, hng, cm x, bng lng, lim, sn, kate.v.v c bit huyn c khu rng nguyn sinh chn dy T ng. y c hng trm loi ng vt qu him sinh sng v c ghi vo sch tr thnh ti sn qu ca quc gia nh voi, bo, h, t gic, nhiu loi linh trngNgoi ra cn bo lu nhiu loi thc vt c t thi nguyn sinh v cc loi cy dc liu qu nh ng sm, trm hng, m tin...

c. Ti nguyn nc

Ngun nc ngm phn b hu khp trn a bn trong huyn, c tr lng ln su 60-90m,y l ngun cung cp nc b sung cho sn xut v sinh hot vo ma kh, c s dng ph bin cho sinh hot, lm kinh t vn, kinh t trang tri. Tuy nhin trn mt s ni trong vng ngun nc ngm hn ch. Nc ngm c khai thc ch yu thng qua cc ging khoan, ging o, nhng do ngun nc nm tng su nn mun khai thc cn c u t ln v phi c ngun nng lng.

5.2.Hin trng thng tin lin lc

in s dng h thng in li quc gia c qun l s dng bi Cng ty in lc k Nng. C mng li bu chnh vin thng p ng nhu cu cho mi i tng s dng trong x, cc im bu in vn ha u c kt ni internet.

6. Nhn xt chung

T nhng phn tch nu trn, Ch u t nhn thy rng khu t xy dng d n rt thun li tin hnh thc hin. Mt khc cc yu t v t nhin, kinh t, h tng uthun li cho vic trin khai d n.

II. A IM U T NH MY

1. Thng tin chung

a im u t: d n cch trung tm th x Gia Ngha 11 km v hng ng i x Qung Sn, huyn k GLong.

Din tch xy dng: nh my ch bin dc liu sch c xy trn din tch 2ha trong tng s 4,9ha c UBND tnh cp cho cng ty CP Sn xut Ch bin Nng Lm Sn sch k Nng (k Nng APM).

Hin trng a im xy dng:

+ in: Cha c, tuy nhin c ng dy trung th i qua t nh my;

+ Nc: Cha c h thng nc my v ang s dng nc khoan;

+ Cng trnh giao thng: cha c

+ a hnh: i dc 10 n 15o, nn cn c san i to thnh bc thang trc khi xy dng nh my.

2. t ai

t rng, rng cn t chuyn thnh ry trng c ph, c m, tiu. Tuy nhin, t y l t ngho, nng sut thp, tng canh tc su, b mt nhiu qung boxit.

Nhu cu t cho vng nguyn liu v t xy dng nh my chim t trng rt thp trung khu vc v hon ton l t cng (ang b dn ln chim).

3, Mi trng

+ Ha cht c hi

Trong dy chuyn sn xut, bi thi c th pht sinh t qu trnh cp pht nguyn liu, to ht, pha trn nh hng trc tip n cng nhn tham gia sn xut vn hnh. Tuy nhin, do c tnh ca sn phm do nh my sn xut l tng i c hi nn ton b quy trnh sn xut ti nh my l quy trnh khp kn, cn phi u t h thng ht v kh bi cho ton b dy chuyn; cng nhn tham gia sn xut phi c trang b cc dng c bo h lao ng cn thit (gng tay, khu trang hot tnh, ng,) khi sn xut v phi c o to v an ton ha cht.

+ Nc thi

Mc d nc thi ca nh my c ha cht trong qu trnh x l v ch bin nhng trong phng n x l nc thi doanh nghip u t hin i v phn loi nc thi lm 2 nhm:

- Nhm thng thng: nh my x l theo phng php BIOGAS ly kh lm nhin liu cho ni hi v h thng sy dc liu.

- Nhm c ha cht c hi: Hp ng vi cng ty mi trng m bo x l nc thi t hiu qu ti u nht thi ra ngun mi trng m khng gy nhim, nc thi t qu trnh sn xut s c x l thng qua h thng b x l UASB(Upflow Anaerobic Sludge Blanket)kt hp b Aerotank, kh trng bng Clo trc khi thi ra ngun tip nhn. Cht lng nc u ra m bo t ct A QCVN 40: 2011/BTNMT.

4. Lao ng

+ Lao ng k thut: Vo giai on ban u do lao ng ti a phng cha p ng c, cn a lao ng k thut c o to ti nh my BV Pharma ln, sau y s tng cng o to v s dng ngun lao ng ti ch.

+ Chuyn gia: t Cng ty BV Pharma v t mt s n v ti thnh ph H Ch Minh.

+ Lao ng nng nghip: Dn a phng hin ti ch yu trng c ph, tiu vi phng thc sn xut lc hu, thu nhp thp, t l ngho cn cao. V vy, doanh

nghip s o to v s dng lao ng ti ch, gp phn ci thin i sng kinh t a phng.

+ Phng n lu di v nhn lc: o to ti ch; T chc iu kin n tt thu ht lao ng ngoi tnh. y l phng n c tnh kh thi cao v k Nng ang l a im thu ht u t ln ca khu vc Ty Nguyn vi cc c s ln nh nh my ch bin nng sn; khai thc v ch bin boxit.

Phn IV: PHN TCH, NH GI S B V THIT B,

CNG NGH K THUT V IU KIN CUNG CP CC VT T, NGUYN LIU, DCH V H TNG C S

I. TRANG THIT B NH MY HA DC:

1. Nhng thit b ch yu:

+ H thng chit xut bng dung mi CO2 siu ti hn.

+ H thng chit p sut gim c thu hi dung mi, chng chy.

+ H thng lc khung bn.

+ H thng ni phn ng chu c p sut ln, c trng men s trong li.

+ Ni phn ng trong iu kin nhit rt thp (-80oC) v nhit cao (>350

oC).

+ H thng tinh ch bng phng php sc k dng ln.

+ Ct ct phn t (cho ra cc tinh du c trng lng phn t khc nhau ).

y l cc thit b c hm lng khoa hc cng ngh cao nhng tng i ph bin i vi cc doanh nghip ha hc, nhiu nc sn xut (vi gi c khc nhau, cng ngh khc nhau) v khng b cm xut, cm nhp; d mua.

2. Ha cht: L cc ha cht d mua, d nhp khu, d vn chuyn.

II. CNG NGH

Trong 11 hot cht nh my t mc tiu sn xut c hai nhm (alcaloide ca cy Da cn v hp cht vng Taxan t cy Thng ) c rt t cc quc gia trn th gii sn xut (Da cn: Php, Hungary; Thng : M, n , Trung Quc, c).

sn xut cc sn phm trn i hi cng ngh cao mc d doanh nghip v cc nh khoa hc ca cc vin, trng nghin cu gn 10 nm, lm ch v cng ngh chit, tch (tr cng ngh bn tng hp Docetaxel), nhng mi sn xut qui m Pillot, s lng cha nhiu v gi thnh cn cao.

Phng n sn xut Docetaxel: 3 nm u Vit Nam sn xut 10-Deacetylbaccatin III (10 DAB III) sau chuyn 10 DAB III cho Cng ty Aq Vida

(c) gia cng sn xut Docetaxel. Sau thi gian 3 nm Ch u t s hon thin v tin hnh t sn xut ti Vit Nam.

Cc sn phm khc: Nhm Flavonoide ca cy hoa he, Curcumin t cy ngh; Cepharanthin t cy bnh vi bin c nghin cu, chit, tch ti Vit Nam, tuy nhin vic t chc sn xut cn manh mn, cha c u t,dn ti gi thnh cao v cht lng khng n nh.

Doanh nghip v cc nh khoa hc Vit Nam c th ch ng thit k, la chn my mc, thit b v xy dng nh my, tuy nhin vic tham kho v t vn ca cc i tcl cn thit.

III. VIC TRNG CY NGUYN LIU V CHT LNG DC LIU TRNG TI VIT NAM

1. Cht lng (hm lng hot cht) ca dc liu trng ti Vit Nam c nhiu u vit hn mt s nc sn xut ha cht cng loi (Thng : M, c, Trung Quc; Da cn: Php, Hungary);

+ Cy Thng Vit Nam trng 18 thng c th thu c 10-DAB III, Paclitaxel t nhin t cnh v l (hm lng 10-DAB III: 0,001% v Paclitaxel t nhin: 0,001%). Trong khi ti Trung Quc, ngi ta thu10-DAB IIIv Paclitaxel t nhin t v v r, vi hm lng hot cht tng ng, th thi gian trng phi cn ti 4 nm.

+ Cy Da cn Vit Nam c xut khu sang Php v Hungrary sn xut Vinblastin, Vincvistin, c nh gi l c cht lng cao hn cc nc trong khu vc.

+ Cc cy trng khc:Cy Hoa he Vit Nam l nguyn liu sn xut Rutin, Troxerutin, Quercetin vi hm lng Rutin t trn 31% (trong khi c, chu u hm lng Rutin ch t 7%).Cy ngh Vit Nam: Hm lng Curcumin 5,5%, nng sut c th t trn 40 tn/ha. Trong khi cy ngh n c hm lng Curcumin trn 11% nhng nng sut ch t mc 10 tn/ha.

2. Cc so snh v li th khc

Khi t vn xy dng nh my ha dc ti Ty Nguyn, chng ti cn nhn nhn cc li th khc, th d v t ai: c th d dng m rng din tch. Mt khc cy dc liu c th trng xen cy c ph, trng di tn rng. V din tch c ph Ty Nguyn 500.000 ha c th trng he xen c ph ( c Cng ty nghin cu). Ti Ty Nguyn c nhiu dc liu t nhin qu, ngun cung cp nguyn liu sn xut cc loi ha dc v hng liu khc:

+ Vng ng (Hong Lin r): Sn xut Berberin.

+ Hong ng: Sn xut Palmatin.

+ Tiu (loi lp): Sn xut tinh du tiu.

+ C ph lp, Tr vn: Sn xut Cafein.

+ Mng tang: Sn xut tinh du mng tang.

+ Mng rng: Sn xut tnh du Ylang Ylang.

IV. CC LI TH V XY DNG H TNG K THUT

Vic xy dng nh my ti k Nng trc mt gp kh khn v nhn lc khoa hc cng ngh v cng nhn k thut, nhng c li th:

+ Gn vng nguyn liu.

+ Khng b hn ch qui m khi mun m rng sn xut.

+ Xa khu dn c tp trung.

+ D gii quyt vn mi trng.

+ Vi hai khu lin hp: Sn xut Boxit, sn xut nhm sp hnh thnh, k Nng chc chn l tnh cng nghip pht trin nht Ty Nguyn.

Phn V: PHNG THC XY DNG

I. K HOCH U TIN

Bng 10: Th t cc hng mc u tin u t

TT Bc cng vic v ni dung Yu cu kt qu

Thi gian

B

Bt u

K

Kt thc

(1) (2) (3) (4)

I

1

2

3

4

5

6

u tin 1:u t xy dng PTN R&D Lm th tc t, xy dng. B tr s trong cng ngh. La chn nh my, thit b. u thu v mua bn. Tip nhn, lp t, chy th, o to. Trin khai KH NCKH-CN.

L mt Pillot c kh nng thc hin cc k thut:Chit, tch; Bn tng hp; Bo ch thuc tim, vin m bo an ton cho ngi v mi trng. Xy dng cc qui trnh cng ngh cho sn xut cng nghip v chit, tch, bn tng hp v bo ch sn phm.

S

Sau

khi

c

quyt nh u t

S

Sau 9

thng

I

I

1

2

3

u tin 2:Xy dng vng nguyn liu cho nh my ha dc Chun b t, ging cho trng Thng , Da cn. Hon tt cc qui trnh sn xut-ch bin. Hon tt h s GAPC.

Lm xong cc th tc giao t, thu t, bn giao t. Xy dng c s h tng m bo cho iu kin sn xut. o to GAPC. Trin khai k hoch sn xut ging

Sau

khi

c

quyt nh u t

S

Sau

12

thng

I

II

1

2

3

4

5

6

7

u tin 3: Xy dng xng bo ch thuc ung th Qui hoch: S b tr cc phn xng sn xut v h thng cp thot, x l nc, h tng k thut. La chn cng ngh-thit b bo ch. Xy dng h s thu v my, thit b bo ch. Thit k k thut: Cc phn xng theo tiu chun GPS ca Chu u-Nht bn. Gi thu xy dng v mua bn my-thit b. Trin khai xy dng, lp t, o to. Xy dng cc SOP.

t GPS Chu u/Nht. m bo an ton cho ngi v mi trng. c cp chng nhn GPS

Sau

khi

c

quyt nh u t

S

Sau

24

thng

I

V 1

2

3

4

5

6

u t xy dng nh my ha dc Hon thin qui trnh cng ngh sn xut cc sn phm t Thng , Da cn. B tr s cng ngh. Thit k k thut cc phn xng: Chit, tch, bn tng hp. La chn cng ngh-thit b. Lp h s k thut cho xy dng v my, thit b. Xy dng-lp t-o to-chuyn giao CN.

S

Sau

12

thng

S

Sau

24

thng

II. TIN : TRIN KHAI CC CNG ON C TH CA CC TIU D N (K T KHI IU KIN U T)

1. Xy dng phng th nghim nghin cu v pht trin (PTN)

Bng 11: Tin u t xy dng phng th nghim R&D

TT Ni dung v cng vic u t,

mc tiu

K hoch trin khai (bc 6 thng)

6

thng

u

6

thng

th 2

6

thng

th 3

6

thng

th 4

6

thng

th 5

6

thng

th 6

(1) (2) (3) (4) (5) (6) (7)

I PTN R&D

1 Thit lp h thng Labo lin kt thc hin mc tiu nghin cu d n.

2 Xc lp mc tiu ca cc Labo cc n v lin kt v b sung trang thit b (TTB) cho cc n v (nu cn)

3 Thit k nh, xng PTN R&D

4 Lp h s thu cho TTB PTN R&D

5 Gi thu: Thi cng nh, xng v TTB PTN R&D

6 K hp ng xy dng v mua bn TTB PTN

7 Tip nhn v lp t TTB

8 Chy th

9 o to, xy dng cc SOP cho vn hnh my, TTB PTN.

10 Sn xut th

2. T chc v xy dng vng nguyn liu cho nh my ha dc

Mc tiu: Xy dng hai c s nghin cu trng v ch bin Thng , Da cn, trong : Thng : 10 ha; Da cn: 10 ha.

Sn phm:

+ Ging m bo tin cung ng.

+ Dc liu: m bo cho k hoch sn xut theo tin ca d n.

Bng 12: Tin u t xy dng vng trng cy dc liu

TT Ni dung v cng vic u

t, mc tiu


6

thng

u

6

thng

th 2

6

thng

th 3

6

thng

th 4

6

thng

th 5

6 thng

th 6

(1) (2) (3) (4) (5) (6) (7)

1 Lm th tc chuyn nhng, thu t cho trng Thng (100ha) Da cn (50ha)

2 Thit k v gi thu xy dng c s h tng-k thut cho sn xut ging (Thng , Da cn) ch bin sn phm dc liu (sau thu hoch) (cho hai c s)

3 Xy dng danh mc thu v gi thu my v TTB cho hai c s

4 Sn xut ging cho vng trng nguyn liu (theo tin ).

- Thng : 700.000 cy (4 nm). - Da cn: 1.400.000 cy (2 nm)

5 u t: Nghin cu xc lp qui trnh-cng ngh sn xut ch bin hai cy Dc liu (Thng , Da cn) nng cao hiu qu kinh t-k thut sn phm

6 Nghin cu trng-ch bin cc dc liu trong d n

3. Xy dng nh my ha dc: Sn xut cc sn phm cho bo ch thuc ung th.

Mc tiu: t tiu chun: GPS, bt u sn xut t thng 36; m bo cung cp ha dc nhm Taxon v alcaloide t Da cn cho bo ch thuc ung th ti Vit Nam; Nghin cu: Cc sn phm ha dc t cc HCTN cha ung th.

Sn phm:

+ Alcaloide ton phn t cy Da cn v cao ton phn t cy Thng .

+ Sn xut 10 DAB III: 100 kg/nm;

+ Sn xut cc sn phm ha dc t cy Thng v Da cn theo d n.

+ Cc loi ha dc v cao dc liu: (theo d n).

Bng 13: Tin u t xy dng nh my ha dc


t, mc tiu


6 thng

u 6

thng

th 2

6

thng

th 3

6

thng

th 4

6

thng

th 5

6

thng

th 6

(1) (2) (3) (4) (5) (6) (7)

1 Xc lp qui trnh cng ngh sn xut cc sn phm t cy Thng , Da cn qui m cng nghip.

2 o to nhn lc k thut cho nh my (bao gm c o to ngoi nc)

3 La chn my, TTB cho nh my

4 Lp h s thu mua my v TTB

5 Qui hoch v b tr nh, xng, c s h tng k thut.

6 Thit k nh xng v gi thu xy dng nh xng v c s h tng.

7 Gi thu mua my v TTB cho nh my

8 Lp t my v TTB

9 Sn xut th bn thnh phm

10 Khi ng sn xut cc sn phm ha dc t hai cy Thng v Da cn

4. Xy dng xng bo ch:

Mc tiu:Xy dng xng sn xut thuc ung th t GPS. EURO; Bo m an ton cho ngi v mi trng.

Phn cng: Xy dng xng; My, thit b.

Phn mm: o to, nhn lc.

Bng 14: Tin u t xy dng xng bo ch


t, mc tiu


6

thng

u

6

thng

th 2

6

thng

th 3

6

thng

th 4

6

thng

th 5

6

thng

th 6

(1) (2) (3) (4) (5) (6) (7)

1 Xc lp v tr xy dng nh, xng v phng n iu tr

2 Thit lp cc i tc BCC

3 Xc lp: Phng n chn my, thit b, cng ngh

4 Thit k k thut nh, xng theo tiu chun GPS Chu u

5 Lp h s thu xy dng nh xng, my thit b v gi thu

6 Gi thu xy dng

7 Gi thu my, thit b

8 Lp t nh xng, my thit b

Phn VI: TNG MC U T D N

I. NI DUNG TNG MC U T

1. Tng vn u t

Bng 15: Tng mc u t ca d n

VT: T ng

STT Hng mc Gi tr

trc thu VAT

Gi tr sau thu

1 Chi ph xy dng 126.4 12.6 139.0

2 Chi ph my mc thit b 421.7 42.2 463.9

3 Chi ph qun l d n 6.3 0.6 6.9

4 Chi ph t vn u t xy dng 6.7 0.7 7.4

5 Chi ph khc 1.1 0.1 1.2

6 Chi ph d phng 48.2 4.8 53.0

7 t 20.8 20.8

8 Chi ph nghin cu hon thin cng ngh 23.0 23.0

9 Chi ph o to chy th iu chnh 10.0 10.0

TNG VN U T 664.2 61.0 725.2

2. Tng hp ngun vn cho tng hng mc u t cn huy ng

Bng 16: Tng hp ngun vn cho tng hng mc u t

VT: T ng

TT Ni dung u t Tng

s

Ngun vn ngh

Doanh

nghip Vn vay

NSNN

cp

-1 -3 -4 -5 -6

I Gii quyt cc vn t cho d n 20.8 20.8

II Xy dng nh xng v c s h tng ca d n

139 66 60.964 12.036

1 Nh my ha dc 27 14.964 12.036

2 Xng bo ch thuc 61 61

3 PTN R&D 15 5 10

4 Xng ch bin dc liu 20 20

5 Vn nghin cu nui trng dc liu 16 16

III Trang thit b u t cho d n (ha dc, bo ch, R&D, trng dc liu)

463.9 101 279.15 83.75

1 Nh my ha dc 117.5 101 16.5

2 Xng bo ch 187 187

3 PTN R&D 80 80

4 Ch bin dc liu 45 45

5 My, TTB SX nng nghip 12.4 8.65 3.75

6 Dy chuyn pha ch dch truyn, dung mi 22

IV Nghin cu hon thin cng ngh 23 20 3

V o to, chy th (my-TB) 10 9 1

VI Chi ph khc 1.2 1.167 0.033

VII Qun tr d n 14.3 14.3

VIII Chi ph d phng 53 53

Tng s: 725.2 187.8 437.581 99.819

II. PHNG THC HON TR VN VAY V CHI PH LI VAY

Phng n hon tr vn vay c xut trong d n ny l phng n tr li v n gc nh k hng nm t khi bt u hot ng d n. Phng n hon tr vn vay c th hin c th nh sau:

- T l vn vay 59%

- S tin vay 437.581 T ng

- Thi hn vay 12 nm

- n hn 2 nm

- Li vay 7.8% nm

- Thi hn tr n 10 nm

Khi d n i vo khai thc kinh doanh, c ngun thu s bt u tr vn gc. S tin phi tr mi thng bao gm li vay v khon vn gc u mi thng. Tuy nhin

chnh sch h tr li sut 100% theo ngh nh s 68/2013/Q-TTg ngy 14/11/2013 iu 1 khon 2 v h tr chnh lch li sut.

Bng 17: Tin vay v tr n d kin

VT: T ng

Ngy

D n u k

Vay n trong

k

Tr n trong

k

Tr n gc

Tr li vay

D n cui k

Khon h tr 100%

li vay

Khon h tr chnh

lch li vay

10/1/2016 - 146 -

- 146

10/1/2017 146 292 11

11 438 0.897 0.3861

10/1/2018 438

78 44 34 394 0.897 0.3861

10/1/2019 394

75 44 31 350 0.448 0.3861

10/1/2020 350

71 44 27 306 0.224 0.3861

10/1/2021 306

68 44 24 263 0.112 0.3861

10/1/2022 263

64 44 20 219

0.3861

10/1/2023 219

61 44 17 175

0.3861

10/1/2024 175

57 44 14 131

0.3861

10/1/2025 131

54 44 10 88

0.3861

10/1/2026 88

51 44 7 44

0.3861

10/1/2027 44

47 44 3 (0)

0.3861

CNG 637 438 199

Phn VII: NH GI HIU QU U T

I. HIU QU KINH T:

1. Chi ph: Cc chi ph cu thnh trong gi thnh sn phm

Bng 18: Din gii chi ph sn xut

STT Cu thnh sn phm Phng php tnh

I Chi ph c nh (fix cost)

1.1 Chi ph khu hao nh xng, t ai v thit b my mc

- Chi ph khu hao cho 1 n v sn phm = (Khu hao nh xng, t ai, trang thit b ca

xng bo ch)/ S lng sn phm sn xut trong nm

1.2 Chi ph in nc

- Chi ph in nc cho 1 n v sn phm = tng chi ph in nc mt nm/ S lng sn phm trong mt nm. - Trong : Tng chi ph in nc 1 nm c tnh = 250 triu ng/ thng x 12 thng = 3 t ng. Mi nm tng 3%

1.3 Chi ph lng cng nhn sn xut

- Chi ph lng cng nhn sn xut = tng lng cng

nhn mt nm/S lng sn phm trong mt nm Trong : - S lng cng nhn sn xut d kin 79 ngi, tng lng d kin 610 triu ng/ thng (tng ng 7,32 t ng/nm). Mi nm tng 3%

1.4 Chi ph lng qun l phn xng

- Chi ph lng qun l phn xng = tng lng qun

l phn xng mt nm/S lng sn phm trong mt nm Trong : - S lng qun l phn xng d kin l 4 ngi, tng lng 65 triu ng/ thng (tng ng 780 triu ng/ nm). Mi nm tng 3%

1.5 Chi ph kim tra cht lng - Chi ph kim tra cht lng d kin.

II Chi ph bin i

2.1 Nguyn vt liu chnh Nguyn vt liu chnh = [Gi nguyn vt liu (USD/kg) x T gi la / 1.000.000] x Khi lng nguyn vt liu chnh trong 1 n v sn phm (mg)

2.2 Nguyn vt liu ph Nguyn vt liu ph = 30% x nguyn vt liu chnh

2.3 H hao nguyn vt liu H hao nguyn vt liu = 1,5% x (nguyn vt liu chnh + nguyn vt liu ph)

2.4 Bao b v h hao bao b Bao b v h hao bao b = n gi bao b x (1 + t l h hao bao b)

III Chi ph Licence

- i vi nhm sn phm I v II (nhm sp mc tiu v generic)

Chi ph Licence = 20% x gi thnh phn xng - i vi nhm sn phm III, IV, V: Chi ph Licence = 8% x gi thnh phn xng

Bng19: C cu gi bn s

I Chi ph cng ty v cu thnh chi ph qun l cng ty 10% Doanh thu

II Chi ph Marketing 35% Doanh thu

III Chi ph bn hng 10% Doanh thu

IV Chi ph Logistic 8% Doanh thu

V Chi ph khc (li vay, h hao, bo qun, d phng ri ro, li) 37% Doanh thu

Bng 20: Bng tng hp chi ph sn xut

VT: T ng

NM

HNG MC 1 2 . 9 10

Chi ph lng nhn vin 8.1 8.3 10.3 10.6

Chi ph BHYT,BHXH 1.7 1.8 2.2 2.2

Chi ph in nc 3.0 3.1 3.8 3.9

Chi ph kim tra cht lng 5.7 5.7 6.1 6.1

Nguyn vt liu v bao b 53.6 109.8 177.3 177.3

Chi ph Licence 10.1 18.8 28.1 28.1

Chi ph qun l 35.9 66.7 103.8 103.8

Chi ph marketing 125.5 233.6 363.2 363.2

Chi ph bn hng 35.9 66.7 103.8 103.8

Chi ph Logistic 28.7 53.4 83.0 83.0

Li vay h tr 32.8 30.0 6.4 3.0

TNG CNG 341.0 597.9 887.9 885.0

2. K hoch sn xut:

Bng 21: Sn lng d kin k hoch sn xut cho 10 nm cho cc sn phm mc tiu (nhm I v II)

TT Tn hng VT K hoch sn xut 10 nm Tng cng

10 nm 4 nm u 3 nm tip theo 3 nm cui

I Nhm sn phm mc tiu

1 Paclitaxel 100mg L 70.000 60.375 69.431 199.806

2 Docetaxel 20mg L 50.000 43.125 49.594 142.719

3 Vinorelbin 50mg L 25.000 21.563 24.797 71.359

4 Vinblastin 10mg Amp 5.000 4.313 4.959 14.272

5 VinCristin 1mg L 100.000 86.250 99.188 285.438

6 Vinorelbin 20mg Vin 25.000 21.563 24.797 71.359

7 Oxaliplatin 50mg L 25.000 21.563 24.797 71.359

8 Cis-Platin 10mg L 50.000 43.125 49.594 142.719

9 Carbo Platin 150mg L 50.000 43.125 49.594 142.719

Cng nhm I:

400.000 345.000 396.750 1.141.750

II Cc sn phm generic

1 DoxoRubixin 10mg ng 250.000 215.625 247.969 713.594

2 Anastrazole 1mg Vin 2.000.000 1.725.000 1.983.750 5.708.750

3 Gemcitabi 200mg L 150.000 129.375 148.781 428.156

4 Etoposide 50mg L 125.000 107.813 123.984 356.797

5 Methotrexate 2,5mg Vin 1.000.000 862.500 991.875 2.854.375

6 Tamoxiphen 10mg Vin 2.500.000 2.156.250 2.479.688 7.135.938

7 Cyclophospharmide 50mg Vin 2.500.000 2.156.250 2.479.688 7.135.938

8 Methotrexate 50mg ng 50.000 43.125 49.594 142.719

9 Ciclosporin 25mg Vin 2.500.000 2.156.250 2.479.688 7.135.938

10 Cyclophospharmide 200mg ng 150.000 129.375 148.781 428.156

11 Etoposide 50mg Vin 200.000 172.500 198.375 570.875

Cng nhm II:

11.425.000 9.854.063 11.332.172 32.611.234

Bng 22: Sn lng d kin k hoch sn xut cho 10 nm cho cc sn phm

h tr iu tr ung th v chng au (nhm III v V)

TT Tn hng VT

K hoch sn xut 10 nm

Tng cng 10 nm

Mc tiu SX & tiu

th 1 nm Nm 1 Nm 2 Nm 3 Nm 10

1 2 3 4 5 6 7 14 15

III Nhm dch truyn v chng au h tr iu tr ung th

1 DISO+NaHCO3 100 Chai 150.000 45.000 105.000 150.000 173.250 1.445.354

2 DISO+Paracetamol Chai 200.000 60.000 140.000 200.000 231.000 1.927.139

3 DISO+FDP 100 Chai 200.000 60.000 140.000 200.000 231.000 1.927.139

4 DISO+ALA: 50 Chai 200.000 60.000 140.000 200.000 231.000 1.927.139

5 DISO+BVP: 50 Chai 200.000 60.000 140.000 200.000 231.000 1.927.139

6 DMSO+Matrime

0,2g/500ml Chai 200.000 60.000 140.000 200.000 231.000 1.927.139

7 Omeprazole 40mg Chai 270.000 81.000 189.000 270.000 311.850 2.601.637

8 Esomeprazole (ng kh)

Chai 250.000 75.000 175.000 250.000 288.750 2.408.923

9 Tramadol 100mg/2ml Amp 250.000 75.000 175.000 250.000 288.750 2.408.923

10 Pethidime 100mg/2ml Amp 250.000 75.000 175.000 250.000 288.750 2.408.923

11 Morphine 10mg/10ml

(tim ty sng) Amp 150.000 45.000 105.000 150.000 173.250 1.445.354

Cng nhm III:

2.320.000 696.000 1.624.000 2.320.000 2.679.600 22.354.807

IV Nhm sn phm gia cng

-

1 Nhm sn phm ampoul

Amp 5.330.000 1.599.000 3.731.000 5.330.000 4.557.150 44.695.656

2 Nhm sn phm dung dch tim truyn

Chai 330.000 99.000 231.000 330.000 282.150 2.767.273

3

Nhm sn phm capsoul (trong dy

chuyn thuc ung th) Caps 11.000.000 3.300.000 7.700.000 11.000.000 9.405.000 92.242.442

4 Nhm sn phm capsoul ng dc

Caps 6.245.000 1.873.500 4.371.500 6.245.000 5.339.475 52.368.550

Cng nhm IV:

22.905.000 6.871.5000

16.033.500

0 22.905.000 19.583.775 192.073.920

V Nhm thuc YHCT:

-

1 Exelis 500mg Caps 1.000.000 300.000 700.000 1.000.000 1.155.000 9.635.693

2 Nm VC + CMC Gi 2.000.000 600.000 1.400.000 2.000.000 2.310.000 19.271.385

3 VC+Curcumin (nano) Gi 2.000.000 600.000 1.400.000 2.000.000 2.310.000 19.271.385

4 Bongaxo cream 15g Tube 200.000 60.000 140.000 200.000 231.000 1.927.139

5 Tetraodotoxin 0,2mg Caps 500.000 150.000 350.000 500.000 577.500 4.817.846

6 Dihydro Quercetin

0,5g + VitC 0,5g Caps 2.000.000 600.000 1.400.000 2.000.000 2.310.000 19.271.385

7 Du gc + SOC Soft 1.000.000 300.000 700.000 1.000.000 1.155.000 9.635.693

8 VIHACOPEN Soft 500.000 150.000 350.000 500.000 577.500 4.817.846

9 Pollen-ng kh 1g Caps 2.000.000 600.000 1.400.000 2.000.000 2.310.000 19.271.385

Cng nhm V:

11.200.000 3.360.000 7.840.000 11.200.000 12.936.000 107.919.758

3. Tng hp doanh thu

Bng 23: Tng hp doanh thu 10 nm theo mc tiu d n

VT: T VN

NM 1 2 3 . 9 10

I Nhm sn phm mc tiu 86.1 86.1 86.1

113.9 113.9

II Cc sn phm generic 41.0 40,985 40,985

54.2 54.2

III Nhm dch truyn v chng au h tr iu tr ung th

90.0 208.9 298.4

344.6 344,65

2

IV Nhm sn phm gia cng 22.0 51.1 73.0

62.4 62.4

V Nhm thuc YHCT: 120.1 280.4 400.5

462.6 462.6

TNG CNG 358.6 667.4 899.0

1,037.7 1,037.7

4. Li nhun:

Bng 24: Bng tnh khu hao v li nhun ca d n VT: T VN

Nm 1 2 9 10

Doanh thu 358.6 667.4 1,037.7 1,037.7

Chi ph hot ng 308.2 567.9 881.4 882.0

Chi ph khu hao 73.3 73.3 63.5 63.5

Li nhun trc thu (22.8) 26.2 92.7 92.2

Thu TNDN - - 18.5 18.4

Li nhun sau thu (22.8) 26.2 74.2 73.8

5. Ngn lu:

Bng 25: Bng tnh dng tin vo v ra ca d n (t lc u t cho n nm th 11)

VT: T VN

Nm 0 1 2 9 10 11

NGN LU VO

Doanh thu

358.6 667.4 1037.7 1037.7

Thu hi ti sn thanh l

10.4

Tng ngn lu vo 0.0 358.6 667.4 1037.7 1037.7

NGN LU RA

Chi ph u t ban u 725.2

Chi ph hot ng

308.2 567.9 881.4 882.0

Tng ngn lu ra 725.2 308.2 567.9 881.4 882.0

Ngn lu rng trc thu -725.2 50.5 99.5 156.3 155.7

Thu TNDN

18.5 18.4

Ngn lu rng sau thu -725.2 50.5 99.5 137.7 137.3

H s chit khu 1.00 0.93 0.86 0.50 0.46

Hin gi ngn lu rng -725.2 46.7 85.3 68.9 63.6

Hin gi tch lu -725.2 -678.5 -593.2 19.8 83.4

6. Hiu qu v ti chnh:

NPV 83.43 t ng

IRR 10.24%

Thi gian hon vn 9 nm

- Hin gi thu nhp thun ca d n l: NPV = 83.43 t ng >0 - Sut sinh li ni b l: IRR = 10.24% - Thi gian hon vn tnh l 9 nm

Qua qu trnh hoch nh, phn tch v tnh ton cc ch s ti chnh trn cho thy d n mang li li nhun cao cho ch u t, sut sinh li ni b cng t s k vng ca nh u t.

D n D n u t nh my sn xut ha dc t dc liu c nhiu tc ng tch cc n s pht trin kinh t x hi. ng gp vo s pht trin v tng trng ca nn kinh t quc dn ni chung v ca khu vc ni ring. Nh nc v a phng c ngun thu ngn sch t Thu GTGT, Thu Thu nhp doanh nghip. To ra cng n vic lm cho ngi lao ng v thu nhp cho ch u t.

II. HIU QU X HI:

1. Hiu qu vi ngnh dc

Nng cao v th ca ngnh cng nghip dc Vit Nam vi v th ca ngnh dc Vit Nam nh B Y T nh gi: hn 90% nguyn liu phi nhp khu (iu cn ni r l k c dc liu cng nhp khu n 80%) sn xut. Cc thuc thng thng, vi cc dng thuc thng thng v cha cc bnh thng thng.

Th vic, chng ta t sn xut ha dc v thnh phm cc sn phm (Paclitaxel, Docetaxel, Vincristin, Vinorelbin ) vn l c quyn ca cc tp on dc phm ln TOP 10 ca th gii nh BMS, Aventis, Roche, Pierre Fabre.

chng minh cho vic, cc nh khoa hc Vit Nam hon ton c th lm nhng vic m cc nc giu, c nn cng nghip tin tin lm.

2. Khai thc tim nng cy, con dc liu Vit Nam

Vit Nam c li th hn nhiu nc v tim nng pht trin cy, con lm thuc, phong ph v chng loi, hm lng hot cht cao.T nhng nm 1985 n nm 2005, Vit Nam xut khu cy da cn sang Php (Pierre Fabre), Hungary (Rideon Richter) sn xut Vinblastin, Vincristin, Vinorelbin. Cy thng ca Vit Nam trng 18 thng c thu chit xut Paclitaxel; trong khi Trung Quc phi trng 4 nm. Rutin: Cy he Vit Nam c hm lng rutin ln hn 30% trong hoa kh, trong khi cy he ca Bulgaria ch c 14% v mch ba gc ch c 3,5%.

3. Hnh thnh r hn ngnh cng nghip ha dc Vit Nam i t th mnh dc liu, nh ch o ca B Chnh Tr BCH Trung ng ghi trong NQ46/NQ-TW ngy 23/2/2005 Pht trin ngnh dc Vit Nam thnh ngnh kinh t - k thut mi nhn.

3.1 Thuc t cy, con c trong t nhin: T khi c loi ngi, con ngi bit dng cy, c cha bnh nh l mt bn nng sinh tn, cho n khi khoa hc k thut pht trin mi xut hin thuc ty.

3.2 Trong danh mc thuc thit yu, c 30% thuc c ngun gc t thin nhin v 70% thc phm chc nng c ngun gc t thin nhin.

3.3 Vit Nam c th mnh v dc liu, chng ta c th sn xut hng trm sn phm thuc thit yu, thuc ti cn, nhng hin vn ang nhp khu, do ngnh dc Vit Nam qu thp b, thiu vn, thiu B .

Sau s kin Vit Nam sn xut thuc ung th t dc liu Vit Nam chc chn s c nhiu doanh nghip Vit Nam u t vo sn xut ha dc t cy c, khi ngnh dc mi c th tr thnh ngnh kinh t - k thut mi nhn.

4. Hiu qu x hi

4.1D n tp hp c i ng cn b khoa hc cng ngh trong nhiu lnh vc chung sc thc hin cc mc tiu cad n:

- Nng - Lm nghip

- Ha hc, ha cc hp cht t nhin

- Dc hc, sinh hc

- Thit b - Cng ngh.

Mt khc thng qua vic trin khai d n, nh nc s c thm l lun v thc tin b sung cho chnh sch khoa hc cng ngh, chnh sch i vi cc nh khoa hc, thc s lc lng khoa hc cng ngh l ng lc pht trin kinh t - x hi ca t nc. D n gp phn lm r thm c s l lun v hp tc gia 4 nh: Nh nc nh khoa hc nh nng nh doanh nghip, khng c s hp tc gia 4 nh th kinh t - k thut ca Vit Nam (c bit: L nc ngho i ln t sn xut nh, 70% sn xut nng nghip) kh c th pht trin.

4.2Nhiu ngi bnh ung th c tip cn vi dch v chm sc y t ca nh nc, gi thuc r. Theo tp ch ung th s 1-2010 hng nm s ngi cht do ung th vo khong 75.000 ngi, s ngi mc mi khong trn di 200.000 ngi (nm 2010: 216.000 ngi). Con s ngi mc ung th phi iu tr hng nm ln ti 2 triu ngi, nhng ch c di 30% ngi mc ung th c kh nng tip cn vi cc dch v y t v chi ph tn km, gi thuc cao.

PHN VIII: NGH V KIN NGH

I. C S XUT NGH V KIN NGH:

1. Ch trng ca ng v Nh nc trong vic u t xy dng nh my ha dc, sn xut nguyn liu, sn xut thuc cho phng v cha bnh ni chung v ung th ni ring.D n u t ny c xut theo mc tiu, k hoch ca Chnh ph c ghi ti cc Quyt nh:

+ Quyt nh s 61/2007/Q-TTg ngy 7/5/2007 v Chng trnh nghin cu khoa hc cng ngh trng im quc gia pht trin cng nghip ha dc n nm 2020;

+ Quyt nh s 43/2007/Q-TTg ngy 29/3/2007 v pht trin cng nghip dc v xy dng m hnh cung ng thuc ca Vit Nam giai on 2007 2015 v tm nhn n 2020;

+ Quyt nh s 348/Q-TTg ngy 22/02/2013 ca Th tng Chnh ph v ph duyt Chng trnh nghin cu o to v xy dng h tng k thut cng ngh cao.

2. Cc xut kin ngh trong d n l da trn cc vn bn ca Chnh ph:

+ Ngh nhs210/2013/N-CP 19/12/2013 v Chnh sch khuyn khch doanh nghip u t vo nng nghip nng thn.

+ Ngh nh s55/2015/N-CP ngy 9/6/2015 v Chnh sch tn dng phc v pht trin nng nghip, nng thn.

+ Quyt nh ca Th tng Chnh ph s68/2013/Q-TTg ngy 14/11/2013 v Chnh sch h tr gim tn tht trong nng nghip.

+ Quyt nh ca Th tng Chnh ph s 61/2007/Q-TTg ngy 7/5/2007 ph duytChng trnh nghin cu khoa hc cng ngh trng im quc gia v pht trin cng nghip ha dc n nm 2020, c tnh n nm 2030

II. CC XUT V KIN NGH

1. H tr xy dng d n:

t ai: c min, gim theo Ngh nh ca Chnh ph s: 210/2013/N-CP theo cc iu 5, iu 6, iu 7 min tin s dng t, min tin thu t, mt nc, min gim tin s dng t khi chuyn mc ch s dng theo N 210/2013/N-CP (hoc giao t ng tin tin s dng t mt ln nu doanh nghip phi b tin n b, gii phng mt bng, mua li t ca dn nh nc coi y l khon ng tin mt ln).

H tr tin u t: Theo Ngh nh s 210/2013/N-CP cc iu 9, iu 12, iu 16 mc h tr: Mc ti a.

H tr gim tn tht trong nng nghip: Theo Quyt nh ca Th tng chnh ph s 68/2013/Q-TTg ngy 14/11/2013.

2.Ngn sch h trtheo quyt nhs 68/2013/Q-TTg

2.1. H tr 100% li sut theo iu 1 khon 2a, 2b, 2. Thi hn vay ngh: Theo mc ti a 05 nm.

2.2. H tr chnh lch li sut, thi gian h tr 12 nm theo iu 2 khon 4, 5:

2.3. Cc mc h tr qui nh ti iu 2, khon 2b, khon 2a vi mc vay: 70%.

3.Chnh sch tn dngtheo Ngh nh s55/2015/N-CP ngy 9/6/2015:

ngh Nh nc ghi c th trong giy chng nhn u t: c vay ngn hng thng mi 80% gi tr d n khng cn ti sn th chp.

ngh cc khon h tr ni mc 2, mc 3 ni trn c cp t ngn sch Trung ng.

4. H tr u t xy dng phng th nghim trng im v chit, tch bn tng hp ha dc t cc hp cht thin nhin.

4.1. Cn c xut:

+ Quyt nh s 348/Q-TTg ngy 22/02/2013 v Nghin cu u t vo xy dng h tng k thut cng ngh cao.

+ Quyt nh s 61/2007/Q-TTg ngy 7/5/2007 v Chng trnh nghin cu khoa hc cng ngh trng im quc gia pht trin cng nghip ha dc n nm 2020.

4.2. ngh:Chnh ph, B Cng Thng, B Y t, h tr Cng ty c phn BV Pharma cng nhm cc n v nghin cu v ha dc ti TP.HCM gm cc n v:

- i hc Bch khoa TP.HCM (Khoa ha dc). - i hc Khoa hc t nhin TP.HCM (Khoa ha) - i hc Y dc TP.HCM (Khoa dc) - i hc Nng lm TP.HCM - Vin ha Phn vin TP.HCM (Vin khoa hc Vit Nam)

xy dng phng th nghim trng im chung ca c 6 n v theo Quyt nh s 61/2007/Q-TTg v ha dc thc hin mc tiu nghin cu ca d n v chng trnh ha dc trng im quc gia.

(Cng ty c phn BV Pharma s c n thnh lp Vin nghin cu sn xut ha dc t cc hp cht thin nhin trnh B v Chnh ph)

Tp. H Ch Minh, ngy 25 thng 6 nm 2015 CNG TY C PHN BV PHARMA

TNG GIM C

NGUYN QUC DNG

T.T Thuc & Nhm thuc

(Theo m ACT) VT n gi S lng Thnh tin

(1) (2) (3) (4) (5)

A THUC KIM T BO 1.208.461.000.000

I TC NHN ALKYL HA

(NITROGENMISTANRD)

1

Nhm Chlor methin & thuc tng t

19.430.000.000

1.1 MELPHALAN (2mg. 5mg ) Vin 115.000 2.000 230.000.000

1 Alkeran(2mg.5mg).Melphalan 50mg Vin

1.2

CYCLOPHOSPHAMIDE(50mg.

200mg)

2 Cyclophosphamid 200mg/l - Tim l 50.000 150.000 7.500.000.000

3 Cyclophosphamid 50mg/vin Vin 3.700 2.500.000 9.250.000.000

( Cyclostin .Cytoxan .Endoxan )

1.3 ESTRAMUSTIN PHOSPHATE

4 Ifosfamid 1g /l l 490.000 5.000 2.450.000.000

( Holoxan . Ifoslib )

2 Dn cht Alkyl sulfonate

2.1 BUSULPHAN

(1) (2) (3) (4) (5)

5 Busulphan 2mg

6 Misulban 2mg

7 Mitobronitol 250 mg

8 Treosulfan

3 Dn cht Nitroso-Ur

3.1 LOMUSTIN

9 Lomustin 40 mg Vin

3.2 STREPTOZOCIN

10 Carmustin 100 mg Tim

3.3 CAMUSTIN

11 Cinu

12 Fotemustin 208 mg Tim

4 Dn cht khc Triazine 4.095.000.000

4.1 ALTRETAMIN

13 Altretamin 100 mg Tim

14 Hexastat 100mg Tim

4.2 TEMOZOLOMIDE

15 Pipobroman 25mg Vin

4.3 DACARZIN (100mg .200mg)

16 Dacarbazine 100mg Tim

17 Dacarbazine 200mg l 409.500 10.000 4.095.000.000

( Detimedac )

II TC NHN (CC CHT) CHNG CHUYN HA

1 Cht tng t acide Fulic 21.090.000.000

1.1 METHOTREXAT

18 Methotrexat 2.5mg /vin vin 17.500 1000000 17.500.000.000

19 Emthexate 50mg /ng ng 71.800 50.000 3.590.000.000

(Ledertrexate. Emthexat)

2 Cht tng t Purin 2.337.500.000

2.1 MERCAPTOPURIN (6MP)

20 Azathioprin 50mg Tim

21 Mercapto 50mg Vin 9.350 250.000 2.337.500.000

22 Tioguanun 50mg Vin

3 Cht tng t Pyrimidin 365.610.000.000

3.1 FLUORO-URACIL (5 FU)

23 Adrucil 500 mg Tim 105.000 100.000 10.500.000.000

(1) (2) (3) (4) (5)

(Curacil .Utoral )

3.2 GEMCITABIN

24 Gemcitabin 200mg/l Tim 630.000 150.000 94.500.000.000

3.3 CYTARABIN

25 Alexan 100mg /500mg/ng tim ng 61.000 10.000 610.000.000

26 Cyrarabine 500mg/ng ng 65.000 4.000.000 260.000.000.000

3.4 FLUDARABIN

3.5 PENMETREXED

Cytosar 1g; 2g Tim

III CC ALCALOIDE T THC VT & SP T NHIN KHC

1

Alealoide ca Vincarusa & tng t

488.720.000.000

1.1 VINBLASTIN 10mg/10ml ng 294.000 5.000 1.470.000.000

27 Cytoblastin 10mg Tim

28 Velb/Velban

1.2 VINCRISTIN

29 Cytocristin 1mg/l Tim 115.000 100.000 11.500.000.000

30 Cytocristin 2mg Tim

1.3 VINORELBIN (50mg ) l 3.900.000 25.000 97.500.000.000

31 Vinorelbin 2mg Vin 1.470.000 25.000 36.750.000.000

1.4 PACLITTAXEL

32 Paclitaxel 100mg - Tim /l L 3.900.000 70.000 273.000.000.000

1.5 DOCETAXEL

33 Taxothere 20mg/ng ng 1.370.000 50.000 68.500.000.000

34 Docetaxel 20mg/ng ng

1.6 ESTRAMUSTIN

35 Emcyt

2

Cc cht dn PODOPHYLLOTOXIN

73.625.000.000

2.1 ETOPOSIDI

36 Etoposide 50mg/vin Vin 65.000 200.000 13.000.000.000

37 Etoposide 100mg/l - Tim l 185.000 125.000 23.125.000.000

2.2 IRINOTECAN

38 Campto 40mg/100mg/ng 20ml ng 1.250.000 30.000 37.500.000.000

39 Ir Nocam mg Tim

2.3 TENIPOSID

40 Teniposid 50mg Tim

(1) (2) (3) (4) (5)

41 Vumon 50mn Tim

IV CC KHNG SINH C T BO & CC CHT LIN QUAN

1 Cc Actionmycin

42 ACTIONMYCIN D

43 Adriamycin 10mg Tim

44 Adriblastin (E) 10mg Tim

45 Adriblastina RD 10mg Tim

46 Ametycine (Php) 2mg Tim

47 Blenoxane (M) 15mg Tim

2 Cc anthracyclin v cc cht lin quan

88.100.000.000

2.1 DOXORUBICIN

48 Doxorubicin DBL10mg . Epirubicin Tim 80.000 250.000 20.000.000.000

49

Doxorubicin DettaWest.

Daktinomycin Tim

50 Doxorubicin Ebewe 10mg/ 50mg ng 490.000 120.000 58.800.000.000

51 Doxorubicin Phamacia 2mg Tim

2.2 DAUNORUBICIN

52 Daunomycin 20mg/ng/ tim ng 186.000 50.000 9.300.000.000

3 Cc khng sinh c t bo khc 2.703.500.000

3.1 BLEOMYCIN

53 Bleomycine LardBeck 15mg Tim

3.2 MITOMYCIN C

54 Bleomycine Roger- Bellon 15mg/l l 540.700 5.000 2.703.500.000

V CC HA CHT CHNG UNG TH KHC

1 Hp cht platin 139.750.000.000

1.1 CISPLANTIN

55 Cis-platin DBL 10mg / l l 115.000 50.000 5.750.000.000

55 Oxaliplatin 50mg/ l10ml l 4.600.000 25.000 115.000.000.000

56 Carboplatin 150mg/l l 380.000 50.000 19.000.000.000

57 Crasnitine Tim

2 Cc Methylhydrazin

2.1 PROCARBAZIN

58 Triptorelin 0.1mg Tim

3 Cc ha cht chng ung th khc 3.000.000.000

(1) (2) (3) (4) (5)

3.1 ASPARAGINASE

59 Asparaginaza Tim 600.000 5.000 3.000.000.000

60 Carboplatin Tim

B LIU PHP NI TIT T 210.973.400.000

I HORMON V CC CHT LIN QUAN

1 Cc Estrogen 133.775.000.000

1.1 ETHINYLESTRADID

61 Dutystilbestrot 1mg. 25mg Vin

62 Distilbene 1mg. 25mg Vin

63 Posfestrol 100mg Vin

64 Honvan 120mg Vin

65 Honvan (Thy S) 120mg Vin

66 Stilphostrol (M) 50mg Vin

1.2 FULVESTRANT

67 Faslodex

68 Torennifen

1.3 C CH AROMATASE

69 Anastrazole 1mg (Arimidex) Vin 54.000 2.000.000 108.000.000.000

70 Esemestane (Aromasin) 25mg Vin 82.000 200.000 16.400.000.000

71 Lestrozole (Femara) 2.5mg/vin Vin 75.000 125.000 9.375.000.000

2 Cc Progestogen

2.1 MEGESTROL

72 Apotex 40mg Vin

73 Farlutal 500mg Vin

74 Farlutal Pepot 500mg Tim

75 Gestornon Caproat 2ml Tim

2.2 MEDROXYPROGESTERON

76 Megace 240 ml Ung

77 Megestrol Acetal 40mg Vin

78 Prodasone 100mg Vin

3

Cc thuc tng t Hormon gii phng Gonadotropin

3.1 BUSERELIN

79 Suprefact 1mg Tim

3.2 LEUPRORELIN

80 Lucrin. Enatone 2ml Tim

3.3 GROSERELIN

(1) (2) (3) (4) (5)

81 Zolatex 3.6mg Tim

3.4 TRIPTORELIN

82 Decapeptyl SR 0.1mg/l

II

CC THUC I KHNG HORMON V CHT LIN QUAN

1 Cc khng Strogen 86.064.000.000

1.1 TAMOXIFEN

83 Tamoxifen Ebewe10mg Vin 2.000 2.500.000 5.000.000.000

84 Zitazonium 10mg Vin

(Tamoxifen)

1.2 CORTICOID

85 Prenisolone Vin 184 5.000.000 920.000.000

86 Methyl Prenisolone 16mg Tim 16.000 5.000.000 80.000.000.000

87 Dexamethysone 0.5mg Vin 72 2.000.000 144.000.000

(Pharbaco)

2 Khng Androgen 134.400.000

88 Bicalutamide (Casodex) 50mg/vin Vin 33.600 4.000 134.400.000

89 Flutamide ( Eulexin)

90 Nifutamide ( Nilandon)

3 ng vn LHRH

91 Leuprolide (Lupron)

92 Gosserelin (Zoladex)

C

CC CHT KCH THCH MIN DCH

215.780.000.000

I CC AFTOKIN V CC CHT IU HA MIN DCH

1

Cc yu t kch thch tng trng cm bch cu

1.1 FILGRASTIM 300mcg

5.850.000.000

93 Falgrastim 300mcg Tim 1.170.000 5.000 5.850.000.000

(Leukokine.Neutrofil)

2 Cc interferon 250.000.000.000

2.1 INTERFERON ALFA

94 Peginterferon alfa-2a (135mcg/) ng 2.337.400

95 Peginterferon alfa-2a (180mcg/) ng

3.078.300

96 Interferon 3MIV/0.5ml ng 426.000

97 Interferon 4.5MIV/0.5ml ng 602.200

98

Peginterferon alfa-2b

( 50 . 80 . 120. 150mcg) ng

(1) (2) (3) (4) (5)

99

Interferon alfa-

2b(3MIV.5MIV)/0.5ml ng

100

Interferon alfa-n3

( Natural alpha interferon) ng

2.2 INTERFERON BETA

1a : L 33 mcg (6.6 triu n v Quc t)

Tim

bp

1b : L 300 mcg (9.6 triu n v Quc t)

Tim

di da

3 Cc Interleukin

3.1 ALDESLEUKIN

1.2ml nc ct +18x106vqt (mg) Tim

4 Liu php khng th n dng 165.000.000.000

101 Rutuximab 500mg/50ml l 33.000.000 5.000 165.000.000.000

(Mabthera . Rituxam)

102 Alemtuzumab (Cempath)

5 Min dch liu php 70.000.000.000

5.1 VACCIN BCG Tim

5.2 VACCIN ung th c t cung

6 Thuc iu chnh min dch 44.930.000.000

103 Thalidomide 50mg/vin Vin 58.000 5.000 290.000.000

104

Lenalidomide( Revlimid) 100mg/

vin Vin

108.000 5.000 540.000.000

105 Tacrolimus 1mg; 0.5 mg/vin Vin 29.400 1.500.000 44.100.000.000

( Frograf )

D

TC NHN GY C CH MIN DCH

511.210.000.000

I Tc nhn gy c ch min dch 121.400.000.000

1 CICLOSPORIN 25mg

Vin

nang 17.000 2.500.000 42.500.000.000

Cha cht lng 25.50.100 mg ciclosporin

Truyn tnh mch : 50mg/ml Tim

106 Epirubicin 50mg/ng tim ng 840.000 70.000 58.800.000.000

107 Temozolomid 250mg; 100mg/vin Vin 2.010.000 10.000 20.100.000.000

II Tc nhn gy c ch min dch khc

1 AZATHIOPRIN

Vin nn 50mg Vin

III Tc ng vo h min dch 389.810.000.000

(1) (2) (3) (4) (5)

108 Mycophenolat 180/250/500mg Vin 25.000 500.000 12.500.000.000

109 Mytomycin 10mg/ng ng 263.200 100.000 26.320.000.000

110 Octreotide Acetate 0.1mg ng 190.000 250.000 47.500.000.000

111

Ironotecan (Ironoteca HCL.3H2O)

ng

2.900.000 100.000 290.000.000.000

112 Basiliximab 20mg l 30.000.000 200 6.000.000.000

113 Bicalutamide 50mg/vin vin 50.000 15.000 750.000.000

( Casodex ; Pharmatamid)

114 Hydoxyurea(Hydra;Hytinon)500mg Vin 3.200 500.000 1.600.000.000

115 Goserelin Zoladex 3.6mg ng 2.570.000 2.000 5.140.000.000

E CC LOI THUC KHC 91.145.000.000

116 Imatinib (Guvec) 100mg/vin Vin 403.000 10.000 4.030.000.000

117 Gefinitib ( Iressa) 250mg/v 1 vin Vin 1.200.000 5.000 6.000.000.000

118 Erlotimib ( Tarceva) 150mg/vin Vin 890.000 5.000 4.450.000.000

119 Bortezomib ( Velcade)

120 Trastuzumab 150mg/440mg l 15.550.000 2.500 38.875.000.000

121 Herceptin 440mg l 45.000.000 300 13.500.000.000

122 Calcium .Foliat ( thuc i khng Acide Folic) 5/10/25mg A.Folinic

Vin 90.000 50.000 4.500.000.000

Calcium .Foliat ( thuc i khng Acide Folic) 25/50/100/200/350mg

A.Folinic

Tim

65.000 50.000 3.250.000.000

123 Everolimus ( Afinitor) 5mg 94.000 10.000 940.000.000

124 Benefos ( Clodronate) 400mg/vin Vin 28.000 500.000 14.000.000.000

125 Benefos ( Clodronate) 300mg/ng ng 80.000 20.000 1.600.000.000

F NHNG TC NHN BIT HA

126 Rentinoid ( Atra )

127 Tretinoin ( Atralin)

128 Bexarotene ( Targetin )

129 Asenictrioxide

TOTAL

2.557.569.400.000

Cu thnh gi v phng php tnh gi trong d n:

I. GII THCH:

1. Gi thnh phn xng = Chi ph c nh + chi ph bin i + chi ph bn

quyn.

2. Cch tnh tng ni dung chi ph:

TT Khon mc chi ph P.P tnh

I. Chi ph c nh: (Fix cost)

1.

2.

Khu hao nh, xng. Khu hao my, thit b ca phn xng

- T l khu hao theo qui nh. - ------ - Thi gian khu hao: Tnh chung

10 nm. - P.P khu hao: Phn b vo mt

n v sn phm.

3. Chi ph in, nc P.P phn b: Tng chi ph in nc/lng sn phm sn xut trong k

4. Tin lng cng nhn sn xut trc tip

P.P phn b: Tng lng/lng sn phm sn xut trong k KH.

5. Chi ph lng qun l phn xng P.P phn b: 10% so vi lng cng nhn sn xut trc tip.

6. Chi ph kim tra cht lng bao gm c lu mu bn thnh phm

- 1,0% 1,5%, gi thnh phn xng.

- S lng mu lu (thnh phm) theo qui nh ca qui ch dc

II. Chi ph bin i:

1. Nguyn vt liu chnh (gm c t l h hao)

Tnh theo cng thc pha ch do cng ty qui nh

T l h hao theo nh mc

2. Nguyn vt liu ph (gm c h hao)

Theo cng thc pha ch, thng bng 30% nguyn liu chnh

T l h hao theo nh mc

3. Bao b cc loi (gm c h hao) Theo qui nh ca cng ty T l h hao theo nh mc

4. Nguyn vt liu, dch v mua ngoi Ty theo sn phm

III. Chi ph bn quyn

1. i vi nhm thuc ung th (I v II)

P.P tnh: 10% n 20% gi thnh phn xng

2. Cc thuc khc P.P tnh: 8% gi thnh phn xng tr trc tip cho n v, c nhn.

Cng : Gi thnh phn xng: I + II + III

Bng n gi nguyn vt liu chnh sn xut thuc ung th

STT Nguyn vt liu chnh n gi VT

1 Paclitaxel 90.000,0 USD/kg

2 Docetaxel 140.000,0 USD/kg

3 Vinorelbin (Navelbin) 400.000,0 USD/kg

4 Vinblastin 140.000,0 USD/kg

5 VinCristin 160.000,0 USD/kg

6 Carboplatin 200,0 USD/kg

7 Oxaliplatin 612,0 USD/kg

8 Cis-Platin 200,0 USD/kg

9 DoxoRubixin 405,0 USD/kg

10 Anastrazole 265,0 USD/kg

11 Gemcitabin 131,3 USD/kg

12 Etoposide 38,0 USD/kg

13 Methotrexate 175,0 USD/kg

14 Tamoxiphen 8,0 USD/kg

15 Cyclophospharmide 15,0 USD/kg

16 Methotrexat 175,0 USD/kg

17 Ciclosporin 12,8 USD/kg

18 Methyl Presnisolone 120,0 USD/kg

19 Curcunim 75,0 USD/kg

20 Tetraodotoxin 250.000,0 USD/kg

21 Quercetin 120,0 USD/kg

22 DISCO (DMSO) 14,0 USD/lit

23 NaHCO3 5,0 USD/kg

24 Paracetamon 10,0 USD/kg

STT Nguyn vt liu chnh n gi VT

25 FDP 65,0 USD/kg

26 ALA 60,0 USD/kg

27 Matrin 480,0 USD/kg

28 Omeprazole 65,0 USD/kg

29 Esomeprazol 130,0 USD/kg

30 Tramadol 80,0 USD/kg

31 Pethidime 110,0 USD/kg

32 Morphin 250,0 USD/kg

33 Bt Exelis 50,0 USD/kg

34 Nm vn chi 500,0 USD/kg

35 CMC 70,0 USD/kg

36 Du gc 50,0 USD/lit

37 Sa ong cha 125,0 USD/kg

38 Phn hoa 12,5 USD/kg

39 Vitamin C 12,0 USD/kg

Bng n gi bao b sn xut thuc ung th n v tnh: VND

STT Bao b n gi T l h hao Tng cng n gi

bao b + h hao

1 Chai 8.500 5,0% 8.925,0

2 L 7.660 5,0% 8.043,0

3 Ampoule 2.500 7,0% 2.675,0

4 Capsul 80 5,0% 84,0

5 Tube 1.200 2,0% 1.224,0

6 Gi 800 2,5% 820,0

7 Softgel 350 2,5% 358,8

Lap Du an Xay Dung Nha May Hoa Duoc Tri Ung Thu Tu Duoc Lieu Viet Nam

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Transcript of Lap Du an Xay Dung Nha May Hoa Duoc Tri Ung Thu Tu Duoc Lieu Viet Nam