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8/18/2019 jk hjk fhuik yugifyugi yfui

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Drugs with topical

administration in the oralcavity area


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• A. DRUGS FOR DISEASES OF

THE ORAL MUCOSA, RELATED TISSUESOR DENTAL PATHOLOGY

• B. DRUGS THAT ARE APPLIED TOTHE ORAL MUCOSA IN ORDER TO TREAT

DISEASES CORRESPONDING TO OTHER

AREAS OF THE BODY.


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• A. DRUGS FOR DISEASES OF

THE ORAL MUCOSA, RELATED TISSUESOR DENTAL PATHOLOGY

a)antiseptics)n!n"ste#!i$a% anti"in&%a''at!#( $#*s

c)%!ca% anest+etics

$)antii!tics e)+ae'!statics


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A) ANTISEPTICS

• . O-IDIING AGENTS

• /. HALOGENATED AGENTS

• 0. ACIDs

• 1. PHENOL DERI2ATI2ES• 3. DETERGENTS

• 4. HEA2Y METALS

• 5. HYDRO-IDES 6AL7ALIS)• 8. COLORING AGENTS

• 9. ACTI2E PRINCIPLES OF PLANTS


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A) ANTISEPTICS• . O-IDIING AGENTS

have antiseptic and haemostatic effects and are used as oral-pharyngeal showers in stomatitis, angina and capillary bleeding.

.a. H($#!*en pe#!:i$e

- Exhibits haemostatic effects

- It is administrated as oral showers in stomatitis,gingivitis and non-severe oral mucosa bleeding.

- The concentration of the solutions is 1 to !.

.. S!$i' an$ ca%ci' pe#!#ates

- used to treat gingivitis and ulcerative necroticperiodontitis.

.c. P!tassi' pe#'an*anate


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A) ANTISEPTICS• /. HALOGENATED AGENTS• /.a. Ha%!*ens;• 2.a.a.Iodine:

• " Tinct#e !& i!$ine, E%e'enta% i!$ine 6L*!% s!%ti!n), I!$!&!#', Beta$ine.• /.a..C+%!#ine;• " Ca%ci' +(p!c+%!#ite<• " S!$i' +(p!c+%!#ite 6c!ncent#ati!n 0 t! 3= &!# #e'!>in* !#*anic $e#is),

Da?in s!%ti!n<• " C+%!#a'ines.

• /.a.c.F%!#i$e;• " S!$i' &%!#i$e in t+e &!#' !& s!%ti!ns, >a#nis+es an$ *e%s.• /.. Ha%!*enate$ a*ents;• CHLORHE-IDINE is acti>e a*ainst G#a'"p!siti>e an$ ne*ati>e acte#ia, &n*i,

sp!#es an$ >i#ses an$ $isesta%is+ t+e acte#ia% p%a@e.• C+%!#+e:i$ine +as a p%a@e $isc%!sin* e&&ect, it is n!t i##itatin*, it can a&&ect

taste an$ can p#!$ce t+e $es@a'ati!n !& 'c!sa.• Dai%( se !& c+%!#+e:i$ine ./= '!t+as+ si*ni&icant%( #e$ces $enta%

p%a@e.• C+%!#+e:i$ine is a>ai%a%e in 'an( $!sa*e &!#'s sc+ as; '!t+as+

6C!#s!$(%), %!en*es 6T#ac+isan " c+%!#+e:i$ine %i$!caine, He:!#a%etten "c+%!#+e:i$ine en!caine), *e% 6P%a? !t), p%>e#ie# 6C!%%stan),pe#i!$!nta% pe%%ets 6Pe#i!c+ip ).


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A) ANTISEPTICS

• 0. ACIDs

• 0..B!#ic aci$

• " ea? antiseptic

• " is se$ in t+e t#eat'ent !& '!t+ap+t+ae an$ %ce#s<

• 0./.Sa%ic(%ic aci$

• " e:+iits &n*ici$a%, castic an$?e#at!%(tic e&&ects.


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A) ANTISEPTICS• 1. PHENOL DERI2ATI2ES

1.. P+en!%" is included in "al#hoff solution which is used in

endodontics.

1./. C#es!%

1.0. He:(%#es!#cin!%1.1. T+('!%

1.3. E*en!%

- is extracted from certain essential oils especially

from clove oil, nutmeg, cinnamon, basil and bay leaf.

- It has antiseptic, revulsive and local anesthetic effects.1.4 He:eti$ine is an antiseptic included in the composition of

toothpastes and mouthwashes $%E&'()* + - topical

solution 1! or spray !.


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A) ANTISEPTICS

3. DETERGENTS

" S!$i' %a#(% s%p+ate $/*/ is

a detergent found in many personal care

products such as toothpaste<

" Bena%?!ni' c+%!#i$e is a detergent and

0uaternary ammonium compound with a broad

range of antimicrobial activity.


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A) ANTISEPTICS

• 4. HEA2Y METALS

-" in!#*anic si%>e# sa%ts; SIL2ER NITRATE

6s!%ti!n e:+iits a st#!n* acte#ici$a% e&&ect

an$ = s!%ti!n is se$ t! cate#ie p!%(ps !#

nec#!sis !& spe#&icia% tisse !& t+e ps a*s)<

" c!%%!i$a% si%>e# c!'p!n$s; COLARGOL,

PROTARGOL.


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A) ANTISEPTICS

• 5. HYDRO-IDES 6AL7ALIS)

- ca%ci' +($#!:i$e enters in the composition of pastesfor root canal treatment


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A) ANTISEPTICS

• 8. COLORING AGENTS

- exhibit wea# bacteriostatic effect

- are used in prevention, as dental pla0ue revealer

revealed and in cariology to identify the altered

dentin.- Gentian >i!%et - dye which consists of a mixture

of violet rosanilinis with antibacterial and

antifungal properties.

- Ac#i$ine $(es $acriflavine, proflavine, euflavine,rivanol

- )2o-dyes and 'et+(%ene %e.


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A) ANTISEPTICS• 9. ACTI2E PRINCIPLES OF PLANTS

•R!'as%an $from chamomile flowers, )ftoli2ol

$extract of rose petals•>!%ati%e !i%s 62!sept!%)<

•A'a!ne 6Fa#in*!sept) is used as an antisepticespecially in infections with 3ram-positive bacteria.•San*ina#ine and bloodroot extract is a vegetal

product used in dentistry as a 4.! solution for the

treatment of gingivitis and as anti-pla0ue agent.

/anguinarine is a mixture of

ben2ophenanthride al#aloids extracted from rhi2omes

of Sanguinaria Canadensis.


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B) NON STEROIDAL ANTI"

INFLAMMATORY DRUGS• it is used in gingivitis, stomatitis and some

periodontitis.

• Examples in$!'et+acin , nap#!:en, en($a'ine.

• 5en2ydamide is an anti-inflammatory, antiseptic, andlocal analgesic agent with good penetration intooropharyngeal tissues.

• It is indicated in inflammation of the oropharyngeal

area pharyngitis, tonsillitis, gingivitis, stomatitis,periodontal disease, oral mucosal lesions of variousetiologies $prostheses, irradiation, and accidentalwounds due to dentistry treatments.


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C) LOCAL ANESTHETICS

• ben2ocaine $6entocalm-gel

• lidocaine $/tomacaina-spray

• bupivacaine• mepivacaine.


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D) ANTIBIOTICS

• in sprays, mouth wash $gargle solutions,

collutoriums, gels, dental cones, lo2enges 7

trochs.

• There are also fibers with antibiotics for the

treatment of gum diseases.

• 8ost commonly used tet#ac(c%ines

6tet#ac(c%ine, $!:ic(c%ine, '!n!c(c%ine)

an$ 'et#!ni$a!%.


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E) HAEMOSTATICS

• in sponges, gels etc, are usually used in

order to stop or prevent haemorrhage

associated to diverse stomatology

procedures. Examples 9 &i#in, t+#!'in,>ita'in 7.


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B. DRUGS THAT ARE APPLIED TO

THE ORAL MUCOSA IN ORDER TO TREATDISEASES CORRESPONDING TO OTHER AREAS

OF THE BODY.

• /:5*I;3:)* T)5*ET/ $nitroglycerin,isosorbid dinitrate, etc 9 for coronary

heart disease $avoidance of first pass

metabolism, rapid absorption.


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