Investigation of allergic sensitisation in areas of Hungary with different level of ragweed...
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Transcript of Investigation of allergic sensitisation in areas of Hungary with different level of ragweed...
Investigation of allergic sensitisation in areas of Hungary
with different level of ragweed pollution
Páldy A1 Bobvos J1., Nékám K2., Bitay Zs3., Csajbók V4., Kelemen A5., Major T6.
1 National Institute of Environmental Health, 2Hospital of Brothers of Mercy, Budapest, 3Bács-Kiskun County Dispensary Kecskemét,
4Józsa András Hospital, Nyíregyháza, Szabolcs-Szatmár Bereg County 5Heves County Dispnesary Eger, 6HRCh Hospital of Cardio-pulmonary patients Mosdós
Aim
To investigate the pattern of sensitisation of allergic patients in areas with different level of ragweed pollution
Sampling sites and patients: Kecskemét, Nyíregyháza, Eger
50-50 adult allergic patients Mosdós: 22 allergic patients Study: questionnaire survey
Specific IgE measurement by using a common panel
Cladosporium herbarum Cladosporium herbarum Alternaria alternata Alternaria alternataHámszövet keverék mix of cutaneous tissueMacska hámszövet cat cutaneous tissueKutya hámszövet dog cutaneous tissueKutya szőr dog hairMacska szőr cat hairHázipor keverék (H1, D1, D2, I6) mix of housedustCsótány cocroachDermatophagoides pteronyssinus (poratka) Dermatophagoides pteronyssinus (poratka)Dermatophagoiedes farinae (liszt atka) Dermatophagoiedes farinae (liszt atka)Lepidoglyphus destructor Lepidoglyphus destructorTyrophagus putresentiae Tyrophagus putresentiaeFű keverék (G2,G3,G5,G6,G8,G10,G12,G13,G14,G15,G16)grass mixCsenkesz faj Fescue (Festuca)Kukorica maizeGyom keverék (W6, W9, W10, W12, W20) weed mixLándzsás útifű plantain (Plantago)Fehér libatop Goose-foot family(chenopodiaceae)Aranyvessző golden rodnagy csalán nettle family (Urticaceae)Fekete üröm Mugwort (Artemisia)Szőrös disznóparéj Amaranth (Amaranthus)Juh sóska Sorrel (Rumex)Közönséges falgyom Common pellitory (Parietaria erecta)Ürömlevelű parlagfű ragweed (Ambrosia)Fa keverék (T1, T2,T 3, T4, T7, T11, T12, T14)mix of trees)Juhar Maple (Acer)Hamvas éger Alder (Alnus)Nyírfa Birch (Betula)Mogyoró Hazel (Corylus)Platán Plane (Platanus)Fűz Willow (Salix)Magas kőris Ash (Fraxinus)Élelmiszer keverék (F1,F2,F4,F5,F8, F75, F76,F77,F78,F79,F81)mix of food)Tojásfehérje egg white Tehéntej cow milkBúzaliszt flour of cornRozs ryeTojássárgája egg yellowKazein (marha) caseineÉlelmiszer keverék (F13, F14, F16, F17, F26, F45, F48, F83)mix of food)Földimogyoró peanutSzójabab soybeenDió nutMogyoró hazel nutSzezámmag sesam seedMustár mustardLatex Latex
Examined allergens in children and adult population with symptoms of allergy,
Hungary, 2006
Results
Evaluation of the questionnaire Description of sensitisation Demonstration of the association of
ragweed sensitisation and answers to the questions
Distribution of answers to the questionnaire I.
In Eger and Kecskemét the rate of breast fed patients was higher In Eger and Nyíregyháza the rate of complaints due to feather allergy was high The rate of smokers and rate of mould in flats was the highest in Kecskemét
Sampling site: M - E - K - NY
4321
cou
nt
60
50
40
30
20
10
0
Do you have
allergic symptoms
Feather
Breast-fed
Ever smoked
Mold
Number of sample
Distribution of answers to the questionnaire II.
The leading complaints are housedust mite and pollen allergy – highest in Eger, Allergic skin symptoms and pet allergy – highest in Kecskemét.
Sampling site: M - E - K - NY
4321
cou
nt
60
50
40
30
20
10
0
Dust allergy
Pollen allergy
Food allergy
Allergic skin
symptoms
Pet allergy
Drog allergy
Insect bite
Number of
sample
Distribution of polysensitisation acc. to the questionnaire
Rate of polysensitized patients -highest in Eger, lowest in Nyiregyhaza
Sampling site: M - E - K - NY
4321
Co
un
t
60
50
40
30
20
10
0
Multiple allergy
7
6
5
4
3
2
1
0
Animal hair allergy
Cow hair allergy was reported in Mosdós and KecskemétRate of patients reporting dog hair allergy is high in each site
Sampling site: M - E - K - NY
4321
Su
m
70
60
50
40
30
20
10
0
Cow
Pig
Poultry
Cat
Dog
Type of house and allergic complains
Sampling site: M - E - K - NY
4321
cou
nt
60
50
40
30
20
10
0
Type of house
Other
Housing
district (H)
Block
of f lats (B)
Attached
house (A)
Family
hause (F)
Missing
In Mosdós, majority of patients live in family houses, In Eger and Nyíregyháza the majority of them live in housing district (panel building).
The type of house does not affect the allergic complaints. House dust mite allergy is the most frequent in block houses, drug allergy and skin symptoms – in family houses, pet hair – in panel buildings.
Type of house: F - A - B - H
4321
Su
m
100
90
80
70
60
50
40
30
20
10
0
Insect bite
Drug allergy
Pet allergy
Allergic
skin symptoms
Food allergy
Pollen allergy
Dust allergy
Allergic symptoms and breast feeding
Multiple allergy
76543210
Co
un
t
100
90
80
70
60
50
40
30
20
10
0
Breast fed
Yes
No
Multiallergic symptoms are less frequent among non breast fed patients.
Rate of pollen and mite alleric symptoms are less frequent among breast fed patients.
Breast fed
10M
ea
n
100.0
90.0
80.0
70.0
60.0
50.0
40.0
30.0
20.0
10.0
0.0
Insect bite
Drog allergy
Pet allergy
Allergic
skin symptoms
Food allergy
Pollen allergy
Dust allergy
X
X
X
X
X
X
X
X
X
X
X
X
x
egg yellowcaseinsoybeennut
pea nutgoose featheregg white
cat hairdog cutaneous tissue
cow milkHazel
Cat cutaneous tissueSesam seedLatex
Dog hairSorrrel
AshAlternaria alternataMustard
CocroachRye
AmaranthPlaneWilllow
Golden rodflour mite
grasshousedust mite
HazelMaizeMugworth
UrticaPlantago
MapleCorn wheet
BirchGoose-foot
AshFescue (Festuca)
Common pellitoryRagweed
Cladosporium herbarum
0,0 5,0 10,0 15,0 20,0 25,0 30,0 35,0 40,0
Percentage of sensitisation in the total sample
The most frequently detectable outdoor allergen IgEs by sites
0,0 20,0 40,0 60,0 80,0
Eger
Nyíegyháza
Mosdós
Kecskemét
The most frequently detectable food allergen and animal IgE levels (%) by sites
0,0 10,0 20,0 30,0 40,0 50,0 60,0 70,0
cat cutaneous tissuedog cutaneous tissue
dog hair
goose feather
cocroach
dust mite
flour mite
corn wheet
rye
sesam seed
mustard
latex
%
Eger
NyíegyházaMosdós
Kecskemét
Frequency of sensitisation in Eger
Corn flour
Ash
PlantagoUrtica
CocroachMaize
BirchGoose feather
Plane
Flour mite
Dog hairAmaranth
Golden rodSorrel
RAGWEED
Common pellitory
Cat cutaneous tissue
Sesam seedRye
Willow
Hazel
Alternaria
Housedust mite
Mugwort
Mustard
Goosefoot
Maple
Fescue
0,0 10,0 20,0 30,0 40,0 50,0 60,0 70,0
%
Frequency of sensitization in Kecskemét
Golden rod
Mugwort
Alder
Maple
Latex
Hazel
Urtica
Plane
Sesam seed
RAGWEED
Corn flour
Willow
Sorrel
Ash
Fescue
Mustard
Amaranth
Rye
Birch
0,0 10,0 20,0 30,0 40,0 50,0 60,0
%
Frequency of sensitisation in Nyíregyháza
UrticaGoosefoot
Alder
BirchFescue
PlantagoMugwort
WillowMustaed
Alternaria
Housedust miteGolden rosAmaranth
Corn flourCocroach
Cat cutaneous tissue
Rye
Common pellitory
MapleGoose feather
PlaneSorrrel
Flour miteAsh
Sesam seed
Dog hair
Hazel
MaizeRAGWEED
0,0 10,0 20,0 30,0 40,0 50,0 60,0
%
Frequency of sensitisation in Mosdós
FescueBirch
AlderHazel
MaizeMugwort
PlantagoGolden rod
PlaneAsh
Willow
UrticaRyeCommon pellitory
Sorrel
AlternariaLatex
Flour miteGoosefoot
Cat cutaneous tissue
RAGWEED
Housedust mite
Dog hair
Maple
Amaranth
0,0 10,0 20,0 30,0 40,0 50,0 60,0 70,0 80,0
%
Prevalence of pollen and dust mite allergy complaints in relation to ragweed sensitised patients
Sampling site: M - E - K - NY
4321
N o
f W
1
30
20
10
0
Pollen allergy
No
Yes
In general 33% of patients have IgE against house dust mite - in more than 50% in Nyíregyháza.
In Eger and Kecskemét complaints do not correlate with ragweed IgE positivity
Sampling site: M - E - K - NY
4321
N o
f W
1
100
90
80
70
60
50
40
30
20
10
0
Dust allergy
Yes
No
Detectable anti - ragweed IgE in breast fed and smoking patients
Sampling site: M - E - K - NY
4321
N o
f W
1
30
20
10
0
Breast-fed
No
Yes
In Kecskemét and in Nyíregyháza rate of ragweed IgE pozitivity is higher among non breast fed patients.
In Kecskemét rate of smoking patients is higher among ragweed positive patients
Sampling site: M - E - K - NY
4321N
of
W1
30
20
10
0
Ever smoking
No
Yes
The project was founded by:
National
Research and Development Program - socio-health research
NKFP -1B/022/04. 2005-2006