InmunidadcontraParasitos - UNNE
Transcript of InmunidadcontraParasitos - UNNE
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• TFL 1
• TFL 2
Resistencia innata en humanos contra T. brucei
DaDañño oxidativoo oxidativo
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•• Fagocitosis por macrFagocitosis por macróófagos:fagos:
- Opsonización por el C’
- RLC
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• Liberación de sus gránulos, que contienen proteínas tóxicas
• IRO Schistosoma
Trichuris
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ILIL--1212
INFINF--γγ
TNFTNF--αα
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• NKT: Resistencia a la infección por L. major. No median efecto protector en infección por Trichuris muris
• Tγδ: Se incrementan en sangre de individuos infectados por protozoos y helmintos (IFN-γ, TNF-α, HSP65 en Toxoplasma y Plasmodium)
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• RRP: TLR
(TLR-2)
• PAMP: GPI
(protozoos:
Toxoplasma,
Leishmania,
Plasmodium)
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iNOS
TNF-α
IL-1
IL-12
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Th2
IL-10
PG E-2 LB 1
LT
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• Helmintos: Th2, IgE, Eo, Mastocitos
• Protozoos intracelulares: Th1
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Leishmania major
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L. MajorL. Major
••Resistentes Resistentes (Th1,
IFN-γ). Citocinas: IL-12,
1, 18, 23, 27
••SusceptiblesSusceptibles (Th2).
Citocinas: IL-4, 10, 13,
TGF-β
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• Th2 (Nematodos Intestinales) �
Resistencia = IgE, IgG1, Eosinofilia,
Mastocitosis
• IL-4 (13, 9, 5, 10) � Expulsión de
nematodos intestinales
• Ac anti-IL-4 � Th1 � Susceptibilidad =
IFN-γ, IgG2a
• Ac anti-IL-12 � Th2
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Rol frente a las reinfecciones:
• IgA en mucosas � Giardia
• IgG1 e IgE � T. spiralis
• IgE � Schistosoma
Activación de Mastocitos (RFc)
Cooperación con Eo y Mo en ADCC
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Resistencia al ataque del complemento
• Leishmania � gp63 (C3b � C3bi)
Vía alterna
gp160 = DAF
Expresan un proteína homóloga al
componente C9 del C’ que le permite
romper la membrana del fagosoma y
acceder al citoplasma
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• Alta frecuencia de L T CD4+CD25+
• Activación de linfocitos en forma
inespecífica �Activación policlonal
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