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nlttTEPATYPA

1. Anb6epTci"e", M.: MVlP, :.~ 2. AMHpTaeB

3, Ape~nVlHR'.it

D. HAP. - MoneKynRpHaR 6V10norVlR KneTKVI, T.2. 1986. K.f. HAP. - Oltt~ltt, P19-~8-191, Ay6Ha, 1988. A.3. - ltt3Y4eHVle aKTVlBHOCTVI A~P-Kap60KcVlnas~ VI

.., $p¢n-aMHAoTpaHc¢epa3~ y WTaMMOB APomwe~,Hecy~Vlx MyTa4 V1 V1, ~ , 3aTparHBa~~He 6V10CHHTe3 nypVlHoB de novo. ABTope¢epaT AVlC­

cepTa4V1V1 Ha COHCKaHHe y4. CT o KaHA. 6V1on. HayK. n.: Vl3A. L nrv, 1984 0

Ij 4. ~HMyneB ltto¢o, 6enReBa E.C. - feHeTVlKa, 1977, 13, W8,tl c.1398.I

,I ~

\: )i 8

9

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M.: B~cwa~ WKona, 1983. 7. KaneHAo r.c. - Ycnex~ cosp. 6~on., 1972, 73, rl, c.59. 8. KepK~c ~.~. - ~oKnaA~ AH CCCP, 1939, 24, r4, c.388. 9. KepK~c ~.~. - Ycnex~ cosp. 6~on., 1940, 12, Wl, c.143.

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On the Possible Correlation of Mutagenesis with Gene Activity

On the basis of our experiments on the spontaneous mutagenesis in yeast we proposed the following hypothesis~ the mutation rate of actively working genes is higher than that of the inactive genes. It this paper data from the literature are collected which may serve as a basis for this hypothe­sis:

- dependence of gene activity on the environment; - differences between active and inactive genes (in conformation. in

chemical modification, etc.); - the effect of the activity of the gene on the sensitivity of the gi­

ven DNA segment and on the processes running on it (r:epar~ti~n" recombina­tion, ••• ); . .

- hints on the connect ion between th'e' ra te' of Induced and even sporrtane-] ous mutab iii ty and gene, act iv i ty. ,...:.

, The investigation has been perfonmed at the Laboratory of Nuclear Prob­

lems. JINR. . Preprint of the'.,Joirit Institute'fOr Nuclear Research.'Dubna 1988

4