Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge...
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![Page 1: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/1.jpg)
Impact of Alzheimer’s Disease in MinnesotaBroadening the Research Agenda to Meet the Challenge
Steve Waring DVM, PhD, FACESenior Research Scientist
Essentia Institute of Rural HealthDuluth, MN
![Page 2: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/2.jpg)
Epidemiology of Alzheimer’s DiseaseProjected US Prevalence: 2010 - 2050
Alz Facts and Figures 2014
![Page 3: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/3.jpg)
Epidemiology of Alzheimer’s DiseaseUS Mortality: 2010
SOURCE: Alzheimer’s Association Facts and Figures, 2014* CHAP=Chicago Health and Aging Project
6th leading cause of death in US Deaths = 83,494 (CDC) to 600,000 (CHAP*)
died “from” died “with”
![Page 4: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/4.jpg)
Impact of Alzheimer’s Disease in MinnesotaBaby Boomer Effect 2010-2050
2010 2020 2030 2040 20500
200,000
400,000
600,000
800,000
1,000,000
1,200,000
1,400,000
85+75-8465-74
By 2030, more than 1 in 5 Minnesotans will be an older adult, including all the Baby Boomers.
MN.GOV 2014
![Page 5: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/5.jpg)
Impact on Alzheimer’s Disease in MinnesotaProjected Prevalence: 2010-2050
2010 2020 2030 2040 20500
20,000
40,000
60,000
80,000
100,000
120,000
140,000
160,000
180,000
200,000
85+75-8465-74
101,500
140,600
180,200 184,000
![Page 6: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/6.jpg)
Economics of Alzheimer’s Disease: Research Spending vs Cost of Care (US)
2025 Goal – prevention and treatment for AD
“…without quadrupling research funding to $2 billion a year, that goal is virtually remote.” Robert Egge, VP Public Policy, Alz Association
Research Cost* RatioResearch : Cost of Care
Alzheimer’s 0.5 214.1 1:428
Cancer 5.8 125 1:22
Heart Disease 2.1 109 1:52
HIV/AIDS 3.1 16.3 1:5
NIH funding on research vs total cost of care, 2013
* Sources: Alzheimer’s (Alz Report 2014; Cancer (IOM report, 2013) Heart disease (CDC); HIV (CDC)
![Page 7: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/7.jpg)
Roadmap for Alzheimer’s Research:What we knowWhat we need to know
Changing Trajectories
Preclinical• Modifying risk• Delay onset• Prevention
Clinical
• Preserve function• Improve quality• Aging in place
![Page 8: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/8.jpg)
Reducing the Impact of Alzheimer’s DiseaseBroadening the Research Roadmap
Feldman et al 2014
Working Groups• Basic research• Early development/translational• Prevention trials• Public/private interface
Increased likelihood of success when overlap maximized
Shared output
![Page 9: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/9.jpg)
Interventions to delay onset, slow progression
Prevention of Alzheimer’s DiseaseCompressing morbidity - Prevention by delay
PrevalenceImpact of 5% Reduction (number of individuals less)
Annual 5-year
US 5 million 250,000 1.25 million
MN 100,000 5,000 25,000
Becker et al. Am J Psy 2007
![Page 10: Impact of Alzheimer’s Disease in Minnesota Broadening the Research Agenda to Meet the Challenge Steve Waring DVM, PhD, FACE Senior Research Scientist Essentia.](https://reader030.fdocument.pub/reader030/viewer/2022032517/56649cb95503460f9498054a/html5/thumbnails/10.jpg)
We don't stop playing because we grow old;we grow old because we stop playing
George Bernard Shaw