Gurukul kangri B. Pharm. Syllabus-wef-2013-2014

8/12/2019 Gurukul kangri B. Pharm. Syllabus-wef-2013-2014

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BACHELOR OF PHARMACY

1

51

Department of PharmaceuticalSciencesFaculty of Ayurved & Medical Sciences

Gurukul Kangri Vishwavidyalaya,Haridwar

COURSESTRUCTURE

B. PHARM. FIRST SEMESTER

S.No. Code Theory Course Hrs/

Week

Exam

Hrs.

E.S.E. I.A. Total

Marks

L T C.T. T.A

1. BPM-101 Pharmaceutical Chemistry - I[Inorganic Chemistry]

3 1 3 70 20 10 100

2. BPM-102 Pharmaceutical ChemistryII[Analytical Chemistry]

3 1 3 70 20 10 100

3. BPM-103 Pharmaceutical ChemistryIII[Organic Chemistry-I]

3 1 3 70 20 10 100

4. BPM-104 MathematicsOR 3 1 3 70 20 10 100

5. BPM-105 Biology 1 1 3 40 05 05 50

S.No. Code Practical Course Hrs/

Week

Exam

Hrs.

E.S.E. I.A. Total

Marks

P C.T. T.A

6. BPM-151 Pharmaceutical Chemistry - I[Inorganic Chemistry]

3 4 70 20 10 100

7. BPM-152 Pharmaceutical ChemistryII[Analytical Chemistry]

3 4 70 20 10 100

8. BPM-153 Pharmaceutical ChemistryIII[Organic Chemistry-I]

3 4 70 20 10 100

9. BPM-154 Biology 2 4 40 05 05 50

E.S.E. --- End Semester Examination

I.A. --- Marks for Internal Assessment

L --- Lectures

T --- Tutorials

C.T. --- Class TestT.A. --- TeachersAssessment

Note:-BPM- 104 is for students with PCB at class XII level. BPM- 105 and BPM-109 are for thestudents with PCM at class XII level.


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2

B. PHARM. SECOND SEMESTER


Week

Exam

Hrs.

E.S.E. I.A. Total

Marks

L T C.T. T.A

1. BPM-201 Pharmacology - I [HumanAnatomy & Physiology]

3 1 3 70 20 10 100

2. BPM-202 Pharmaceutics - I [GeneralPharmacy & Dispensing

Pharmacy]

3 1 3 70 20 10 100

3. BPM-203 Pharmaceutics - II [ComputerApplications]

3 1 3 70 20 10 100

4. BPM-204 Environmental Studies 3 1 3 70 20 10 100


Week

Exam

Hrs.

E.S.E. I.A. Total

Marks

P C.T. T.A

5. BPM-251 Pharmacology - I [HumanAnatomy & Physiology]

3 4 70 20 10 100

6. BPM-252 Pharmaceutics - I [GeneralPharmacy & DispensingPharmacy]

3 4 70 20 10 100

7. BPM-253 Pharmaceutics - II [ComputerApplications]

3 4 70 20 10 100

9. BPM-254 Professional Communication 3 4 70 20 10 100



L --- LecturesT --- Tutorials

C.T. --- Class Test

T.A. --- TeachersAssessment

Note:BPM-204 will be qualifying paper and the marks obtained will not be counted in the final

result.


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3

B. PHARM. THIRD SEMESTER


Week

Exam

Hrs.

E.S.E. I.A. Total

Marks

L T C.T. T.A.

1. BPM-301 PharmaceuticsIII[Pharmaceutical Microbiology]

3 1 3 70 20 10 100

2. BPM-302 Pharmaceutics - IV[Pharmaceutical EngineeringOperations]

3 1 3 70 20 10 100

3. BPM-303 Pharmacognosy - I 3 1 3 70 20 10 100

4. BPM-304 Pharmacology - II 3 1 3 70 20 10 100


Week

Exam

Hrs.

E.S.E. I.A. Total

Marks

P C.T. T.A.

5. BPM-351 PharmaceuticsIII[Pharmaceutical Microbiology]

3 4 70 20 10 100

6. BPM-352 Pharmaceutics - IV[Pharmaceutical EngineeringOperations]

3 4 70 20 10 100

7. BPM-353 Pharmacognosy - I 3 4 70 20 10 100

8. BPM-354 Pharmacology - II 3 4 70 20 10 100


I.A. --- Marks for Internal AssessmentL --- Lectures

T --- Tutorials



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4

B. PHARM. FOURTH SEMESTER


Week

Exam

Hrs.

E.S.E. I.A. Total

Marks

L T C.T. T.A

1. BPM-401 Pharmaceutical ChemistryIV[Physical Chemistry]

3 1 3 70 20 10 100

2. BPM-402 Pharmaceutical ChemistryV[Pharmaceutical Analysis-I]

3 1 3 70 20 10 100

3. BPM-403 Pharmaceutical ChemistryVI[Organic ChemistryII]

3 1 3 70 20 10 100

4. BPM-404 Pharmaceutics-V [HospitalPharmacy]

3 1 3 70 20 10 100


Week

Exam

Hrs.

E.S.E. I.A. Tota

Mark

L C.T. T.A

5. BPM-451 Pharmaceutical ChemistryIV[Physical Chemistry ]

3 4 70 20 10 100

6. BPM-452 Pharmaceutical ChemistryV[Pharmaceutical Analysis-I]

3 4 70 20 10 100

7. BPM-453 Pharmaceutical ChemistryVI[Organic ChemistryII]

3 4 70 20 10 100

8. BPM-454 Pharmaceutics-VI[Pharmaceutical Engineering

Drawing]

3 4 70 20 10 100




C.T. --- Class Test



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5

B. PHARM. FIFTH SEMESTER


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

L T C.T. T.A.

1. BPM-501 Pharmaceutical ChemistryVII [Pharmaceutical Analysis

- II]

3 1 3 70 20 10 100

2 BPM-502 Pharmaceutical ChemistryVIII [Heterocycles,

Carbohydrates, Proteins &

Nucleic Acid]

3 1 3 70 20 10 100

3. BPM-503 Pharmaceutical ChemistryIX [Biochemistry]

3 1 3 70 20 10 100

4. BPM-504 Pharmaceutics - VII [PhysicalPharmacy]

3 1 3 70 20 10 100


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

P C.T. T.A.

5. BPM-551 Pharmaceutical ChemistryVII [Pharmaceutical Analysis- II]

3 4 70 20 10 100

6. BPM-552 Pharmaceutical Chemistry

VIII [Heterocycles,Carbohydrates, Proteins &

Nucleic Acid]

3 5 70 20 10 100

7. BPM-553 Pharmaceutical Chemistry -IX [Biochemistry]

3 5 70 20 10 100

8. BPM-554 Pharmaceutics - VII [PhysicalPharmacy]

3 5 70 20 10 100



L --- Lectures

T --- TutorialsC.T. --- Class Test



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6

B. PHARM. SIXTH SEMESTER


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

L T C.T. T.A.

1. BPM-601 Pharmaceutics - VIII[Formulation Techniquesand Cosmeticology]

3 1 3 70 20 10 100

2. BPM-602 Pharmacognosy- II[Natural Products]

3 1 3 70 20 10 100

3. BPM-603 Pharmacology - III[Pathophysiology and

Toxicology]

3 1 3 70 20 10 100

4. BPM-604 Pharmacology - IV 3 1 3 70 20 10 100


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

P C.T. T.A.

6. BPM-651 Pharmaceutics - VIII[Formulation Techniques and

Cosmeticology]

3 5 70 20 10 100

7 BPM-652 Pharmacognosy - II [NaturalProducts]

3 5 70 20 10 100

8 BPM-653 Pharmacognosy - III [PlantCollection Tour]

- 3 - - - 100

9. BPM-654 Pharmacology - IV 3 5 70 20 10 100



L --- Lectures

T --- TutorialsC.T. --- Class Test



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B. PHARM. SEVENTH SEMESTER


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

L T C.T. T.A.

1. BPM-701 Pharmaceutical ChemistryX[Medicinal Chemistry - I]

3 1 3 70 20 10 100

2. BPM-702 Pharmaceutics - IX[Pharmaceutical Management]

3 1 3 70 20 10 100

3. BPM-703 PharmaceuticsX[Pharmaceutical Technology]

3 1 3 70 20 10 100

4. BPM-704 PharmaceuticsXI[Pharmacokinetics &

Biopharmaceutics]

3 1 3 70 20 10 100

5. BPM-705 Pharmaceutics - XII[Pharmaceutical Jurisprudence]

3 1 3 70 20 10 100


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

P C.T. T.A.

6. BPM-751 Pharmaceutical Chemistry- X[Medicinal Chemistry - I]

3 4 70 20 10 100

7. BPM-752 PharmaceuticsX[Pharmaceutical Technology]

3 5 70 20 10 100

8. BPM-753 Pharmaceutics - XI[Pharmacokinetics &

Biopharmaceutics]

3 5 70 20 10 100




C.T. --- Class Test



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8

B. PHARM. EIGHTH SEMESTER


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

L T C.T. T.A.

1. BPM-801 Pharmaceutical ChemistryXI [Medicinal Chemistry -

II]

3 1 3 70 20 10 100

2. BPM-802 Pharmaceutical ChemistryXII [Medicinal Chemistry -

III]

3 1 3 70 20 10 100

3. BPM-803 PharmacologyV [ClinicalPharmacology]

3 1 3 70 20 10 100

4. BPM-804 PharmacognosyIV

[PharmaceuticalBiotechnology]

3 1 3 70 20 10 100


Week

Exam

Hrs.

E.S.E. I.A. Total

marks

L C.T. T.A.

5. BPM-851 Pharmaceutical ChemistryXI& XII [Medicinal Chemistry-II

& III]

3 5 70 20 10 100

6 BPM-852 Pharmacology - V [ Clinical

Pharmacology]

3 5 70 20 10 100

7. BPM-853 Pharmacognosy - IV[PharmaceuticalBiotechnology]

3 5 70 20 10 100

8. BPM-854 Pharmaceutics - XIII [IndustrialTour]

0 3 - - 100


I.A. --- Marks for Internal AssessmentL --- Lectures

T --- Tutorials



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COURSESTRUCTURE

Theory

B.PHARM. FIRST SEMESTER

BPM-101 Pharmaceutical Chemistry - I [Inorganic Chemistry]

BPM-102 Pharmaceutical ChemistryII [Analytical Chemistry]BPM-103 Pharmaceutical ChemistryIII [Organic Chemistry-I]

BPM-104 MathematicsORBPM-105 Biology

Practical

BPM-151 Pharmaceutical Chemistry - I [Inorganic Chemistry]BPM-152 Pharmaceutical ChemistryII [Analytical Chemistry]BPM-153 Pharmaceutical ChemistryIII [Organic Chemistry-I]

BPM-154 Biology

TheoryB.PHARM. SECOND SEMESTER

BPM-201 Pharmacology - I [Human Anatomy & Physiology]BPM-202 Pharmaceutics - I [General Pharmacy & Dispensing Pharmacy]

BPM-203 Pharmaceutics - II [Computer Applications]

BPM-204 Environmental Studies

Practical

BPM-251 Pharmacology - I [Human Anatomy & Physiology]BPM-252 Pharmaceutics - I [General Pharmacy & Dispensing Pharmacy]BPM-253 Pharmaceutics - II [Computer Applications]

BPM-254 Professional Communication

B.PHARM. THIRD SEMESTER

TheoryBPM-301 PharmaceuticsIII [Pharmaceutical Microbiology]BPM-302 Pharmaceutics - IV [Pharmaceutical Engineering Operations]

BPM-303 PharmacognosyI

BPM-304 PharmacologyII

PracticalBPM-351 PharmaceuticsIII [Pharmaceutical Microbiology]BPM-352 PharmaceuticsIV [Pharmaceutical Engineering Operations]

BPM-353 PharmacognosyIBPM-354 Pharmacology - II

Theory

B.PHARM. FOURTH SEMESTER

BPM-401 Pharmaceutical ChemistryIV [Physical Chemistry]

BPM-402 Pharmaceutical ChemistryV [Pharmaceutical Analysis-I]


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BPM-403 Pharmaceutical ChemistryVI [Organic ChemistryII]BPM-404 Pharmaceutics-V [Hospital Pharmacy]

PracticalBPM-451 Pharmaceutical ChemistryIV [Physical Chemistry]BPM-452 Pharmaceutical ChemistryV [Pharmaceutical Analysis-I]

BPM-453 Pharmaceutical ChemistryVI [Organic ChemistryII]

BPM-454 Pharmaceutics-VI [Pharmaceutical Engineering Drawing]

Theory

B.PHARM. FIFTH SEMESTER

BPM-501 Pharmaceutical ChemistryVII [Pharmaceutical Analysis - II]

BPM-502 Pharmaceutical ChemistryVIII [Heterocycles, Carbohydrates, Proteins & Nucleic

Acid]BPM-503 Pharmaceutical ChemistryIX [Biochemistry]

BPM-504 Pharmaceutics - VII [Physical Pharmacy]

Practical

BPM-551 Pharmaceutical ChemistryVII [Pharmaceutical Analysis - II]BPM-552 Pharmaceutical ChemistryVIII [Heterocycles, Carbohydrates, Proteins & Nucleic

Acid]BPM-553 Pharmaceutical Chemistry - IX [Biochemistry]

BPM-554 Pharmaceutics - VII [Physical Pharmacy]

Theory

B.PHARM. SIXTH SEMESTER

BPM-601 Pharmaceutics - VIII [Formulation Techniques and CosmeticologyBPM-602 Pharmacognosy - II [Natural Products]

BPM-603 Pharmacology - III [Pathophysiology and Toxicology]

BPM-604 PharmacologyIV

Practical

BPM-651 Pharmaceutics - VIII [Formulation Techniques and Cosmeticology]BPM-652 Pharmacognosy - II [Natural Products]BPM-653 Pharmacognosy - III [Plant Collection Tour]

BPM-654 PharmacologyIV

Theory

B.PHARM. SEVENTH SEMESTER

BPM-701 Pharmaceutical ChemistryX [Medicinal Chemistry - I]

BPM-702 Pharmaceutics - IX [Pharmaceutical Management]BPM-703 PharmaceuticsX [Pharmaceutical Technology]

BPM-704 PharmaceuticsXI [Pharmacokinetics & Biopharmaceutics]

BPM-705 Pharmaceutics - X II [Pharmaceutical Jurisprudence]

PracticalBPM-751 Pharmaceutical Chemistry- X [Medicinal Chemistry - I]BPM-752 PharmaceuticsX [Pharmaceutical Technology]


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BPM-753 Pharmaceutics - XI [Pharmacokinetics & Biopharmaceutics]

B.PHARM. EIGHTH SEMESTER

TheoryBPM-801 Pharmaceutical ChemistryXI [Medicinal Chemistry - II]BPM-802 Pharmaceutical ChemistryXII [Medicinal Chemistry - III]

BPM-803 PharmacologyV [Clinical Pharmacology]BPM-804 Pharmacognosy - IV [Pharmaceutical Biotechnology]

PracticalBPM-851 Pharmaceutical ChemistryXI & XII [Medicinal Chemistry-II & III]BPM-852 Pharmacology - V [Clinical Pharmacology]

BPM-853 Pharmacognosy - IV [Pharmaceutical Biotechnology]

BPM-854 Pharmaceutics - XIII [Industrial Tour]

Note:-BPM- 104 is for students with PCB at class XII level. BPM-105 and BPM-109 are for thestudents with PCM at class XII level. BPM-204 will be qualifying paper and the marks obtained

will not be counted in the final result.


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FIRST SEMESTER

THEORY

BPM101

PHARMACEUTICAL CHEMISTRYI [INORGANIC CHEMISTRY]

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1 (L+T);Duration of Exam.3 hrs

Instructions to examiners:Two questions should be asked from each unit. Students shall be required to attem

one question from each unit. In all, five questions shall be attempted. All questions shall be of 14 marks each.

NOTE:Topics 3-11 will be treated coveringONLYan outline of methods of preparation, test for identity a

purity including limit test, chemical properties, assay procedures and Pharmaceutical uses.

UNIT I

1. Arrhenius theory for electrolytic dissociation in solutions. Concepts of Acids and Bases, Role of Solv

in deciding the acid-base nature, Common ion effect, Ionic product of water, pH, Buffers, Henders

Hesselbalsch equation, Hydrolysis of salts.

2. Impurities in Pharmaceutical substances and their control.

3. Pharmaceutical aids and necessities: Acids, bases, buffers, antioxidants, water and pharmaceutic

acceptable glass.

UNITII

4. Major Intra and extra-cellular electrolytes: Major physiological ions, electrolytes used in replacem

therapy: Physiological acid-base balance; electrolytes used in acid base therapy; electrolyte combina

therapy.

5. Essential and trace elements, Copper, Zinc, Chromium, Manganese, Molybdenum, Selenium, Sulphur

Iodine.

UNITIII

6. Gastrointestinal agents: Acidifying agents; antacids protective and absorbents: saline cathartics.

7. Topical agents: Protectives, antimicrobials and astringents.

UNITIV

8. Dental Products: Anticaries agents and dentifrices.

9. Nuclear chemistry: Nuclear composition, forces and stability, isotopes, measurement of radioactiv

modes of decay, half life period, artificial radioactivity, application in Pharmacy, Radiopharmaceutic

Radiopharmaceutical preparations and radiopaque contrast media.

UNITV

10. Co-ordination compounds and complexations.


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FIRST SEMESTER

11. Miscellaneous Inorganic Pharmaceutical Agents: Inhalants, respiratory stimulants, expectorants

emetics, antidotes, tableting aids and suspending agents.

List of books recommended (Latest editions unless specified):

1. J. H. Block, E. Roche, T. O. Soine and C.O. Wilson, Inorganic Medicinal and Pharmaceutical Chemis

Lea & Febiger, Philadelphia, PA, USA.

2. L. M. Athorton, Bantley and Drivas, Text Book of Pharmaceutical Chemistry, Oxford University Pr

Delhi.

3. Indian Pharmacopoeia Vol. I & II, Ministry of Health, Government of India (Latest Edition).

4. A. H. Beckett and J. B. Stenlake, Practical Pharmaceutical Chemistry, Part I, The Athlons Pre

University of London, London.

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FIRST SEMESTER

THEORY

BPM102

PHARMACEUTICAL CHEMISTRYII [ANALYTICAL CHEMISTRY] Max.

Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1 (L+T);Duration of exam: 3 hrs

Instructions to examiners: Two questions should be asked from each unit. Students shall be required to attem


UNITI

1. Accuracy and Precision. Expressing the accuracy and precision - Error, Relative error, Deviation, M

deviation, relative mean deviation, standard deviation, relative standard deviation, Variance, Coeffic

of variation.

2. Classification of errors Systematic errors, Random errors and Mistakes, Additive and proportion

errors. Minimization of errors.

3. Significant figures, Rejection Quotient test, Method of least squares.

4. Numerical problems related to the above topics.

UNITII

5. Concept of Mol, g-atom, g-ion, g-formula weight and g-equivalent. Concept of Oxidation-reduct

Oxidation number, balancing of equations, Reactions of commonly used oxidizing reducing age

Equivalent weight of acids and bases, Equivalent weight of oxidizing and reducing agents. Law

equivalence as the basis of Acid-Base titrations and Redox titrations.6. Standard solutions: Expressing the concentration or strength of solutions In Percentage, g/

Normality, m. eq. /ml, Molarity, Formality, Molality, Mol fraction and in P.P.M. Expressing

concentration of H2O2solutions. Concentrations of gases in liquids. Expressing the percentage of SO

Oleum.

7. Numerical problems related to the above topics.

UNITIII

8. Different types ofAcidBase titrations(Strong acidStrong base, Strong acid- Weak base, Weak a

strong base, and Weak acid- weak base).

9. AcidBase indicators, Choice and Theory of these indicators.

10. Multi-step equilibrium, Polyprotic, Polyamine and amino acid systems. Application of acid base titrati

in assay of NaOH, CaCO3& Na2CO3.


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FIRST SEMESTER

11.Non-aqueous Titrations: Theoretical consideration, acid base equilibria in non-aqueous media, acid-b

titrations, indicators, applications.

UNITIV

12.Redox titrations: Iodometry and Iodimetry. Titrations involving Ceric sulphate, potassium iodate,

potassium bromate, Potassium permanganate, Potassium dichromate. Redox indicators (Internal, Exte

and self indicators).

13.Complexometric Titrations: Complexation and chelation, Warner theory and electronic structur

complex ions, stability constants. Types of complexometric titrations, indicators for complexome

titrations, factors influencing the stability of complexes, EDTA-metal ion complexes, determination

hardness of water.

14.Precipitation titrations, Preferential adsorption theory. Functioning of Adsorption indicators. Moh

method and Volhards method.

UNITV

15.Miscellaneous Methods of Analysis: Diazotization titrations, Kjeldahls method for estimation

nitrogen in inorganic compounds, organic compounds, soil and fertilizers, Karl-Fischer titration

estimation of water.

16.Gravimetric Analysis: Precipitation technique related to solubility product. Elementary idea of Collo

state. Super saturation, Co-precipitation and Post precipitation. Digestion, washing of precipit

Filtration, Filter papers and crucibles, Ignition of precipitate. Thermo gravimetric curves. Spec

examples like estimation of barium as barium sulphate, aluminium as aluminium oxide, calcium

calcium oxalate and magnesium as magnesium pyrophosphate, Organic precipitants.


1. K.A.ConnersA Text Book of Pharmaceutical AnalysisWilley Interscience.

2. J.Medham, R.C.Denny, J.D.Barnes, M. Thomas and G.H. JefferyVogels Text book of Quantitat

Analysis. Pearson Education Asia.

3. A.H.Beckett and J.B.StenlakePractical Pharmaceutical AnalysisVol. I & II. The Antherden Pr

of the University, London.

4. British PharmacopoeiaHer Majestys Stationary Office, University Press, Cambridge.

5. A.AlexeyevQuantitative analysisCBS Publishers and Distributors, New Delhi.

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FIRST SEMESTER

THEORY

BPM103

PHARMACEUTICAL CHEMISTRYIII [ORGANIC CHEMISTRYI] Max.

Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1 (L+T);Duration of exam: 3 hrs



UNIT I

1. Structure and Properties: Covalent bonding, Hybridization, Multiple bonds. Electronegativity, Dip

moment, Inductive and field effects. Bond lengths, bond angle and bond energies. Delocalizat

Hyperconjugation, Tautomerism. Hydrogen bonding. Organic acids and bases.

2. Stereochemistry (Basic Concepts only): Optical activity, Chirality, Enantiomers, Diastereomers, D/L

R/S nomenclature. Recemic mixture and resolution. Geometrical isomerism.

UNITII

3. Alkanes: Nomenclature, Physical properties, Industrial source and preparation. Halogenation, Combus

and pyrolitic reactions.

4. Cycloalkanes: Nomenclature, Physical properties, Industrial source and preparation. Bayers strain the

Conformations of cyclohexane.

5. Alkenes, Dienes and Alkynes: Nomenclature, physical properties, industrial source, preparation

addition reactions. Polymerization of dienes. Acidity of alkynes.UNITIII

6. Alcohols, Alkyl Halides and Ethers: Nomenclature, General methods of preparation, physical proper

chemical reactions.

7. Aliphatic nucleophilic substitution: SN1, SN

2 mechanisms. Hydrolysis of esters.

UNITIV

8. Addition to carbon/carbon and carbon/hetero multiple bonds: Electrophilic, nucleophilic and free rad

addition to carbon-carbon multiple bonds, Michael, Mannich, Grignard, Reformatsky, Witting and Pe

reactions. Aldol, Knoevengal and Bezoin condensations.

9. Elimination Reactions: E1, E2, mechanisms, Saytzeff and Hoffman rules.

UNITV

10. Aldehyde and Ketones: Structure, nomenclature, physical properties, industrial source, preparation

reactions. Acidity of hydrogens.


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FIRST SEMESTER

11. Active methylene compounds: Ethyl acetoacetate synthesis and applications in organic synthesis.

List of books recommended (Latest editions unless specified)

1. R.T. Morrison and R.N. Boyd. Organic Chemistry, Allyl and Bacon, Inc., Boston, USA.

2. I.L. Finar, Organic Chemistry, Vol. I and II, The English Language Book Society.

3. P. Sykes, A Guidebook to Mechanisms in Organic Chemistry, Orient Longman, New Delhi.

4. J. March, Advanced Organic Chemistry, Reaction, Mechanisms and structure, Wiley Eastern, New Del

5. S. Pine, Organic Chemistry, McGraw Hill, 1987.

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FIRST SEMESTER

THEORY

BPM104

MATHEMATICS

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1 (L+T);Duration of exam: 3 hrs



UNIT I

1. Algebra: Arithmetic, geometric & harmonic progressions, evaluation ofn, n2

and n3

(Element

treatment only )

2. Trigonometry: Measurement of angle, trigonometrical ratio of sum and difference of ang

transformation formulae, trigonometrical-ratios of multiple and submultiple angles. Logarith

(Elementary treatment only).

UNITII

3. Analytical plans geometry:Cartesian coordinates system, distance between two points, area of triang

Section formula, equation of straight line (slope intercept form, point slope form, two point slope fo

intercept form, general equation of first degree).

UNITIII

4. Calculus: Limit and continuity (elementary concept only), definition of differential coeffic

differential coefficient of trigonometric functions (exclusive inverse circular and hyperbolic function

differential coefficient ofa constant and function, logex, ex, ax, sum of two or more than two functi

product of two functions, quotient of two functions, parametric and implicit function. Differentiating

method of substitution, derivative of a function of second order derivatives. Application of derivative

rate measurer. Maxima and minima of a function of single variable. (elementary treatment only)

UNITIV

5. Integration:Integration as inverse of differentiation, indefinite integral of standards forms, integration

sum and difference of two functions. Integration by substitution and integration by parts.

6. Differential Equation:Formation of a differential equation, order and degree, differential equation of

first order and first degree (equation solvable by separation by the variables, linear equation of the f

order), linear differential equation with constant coefficients.


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FIRST SEMESTER

7. Statistics:

UNITV

Collection, presentation and diagrammatic representation of data, frequency distribution, mea

of central tendency.

Probability: Sample spaces, algebra of events, axiomatic approach to probability, finite sam

spaces combinational problem.

Test of significance: One tailed and two tailed tests, student t-test for single mean, differe

between two means tests of correlation coefficient chi-square test of goodness of fit

independence of attributes, chi-square test for population variance.

--------------------------------------

List of books recommended (Latest unless specified)

1. Gorakh Prasad "Differential calculus

2. Elementary Engineering MathematicsB. S. Grewal Khanna Publishers, Delhi.

3. Gorakh PrasadIntegral Calculus

4. Examples in Statistics by H.C. Sexana, Atma Ram and Sons, Delhi.

5. AyresMathematics and Statistics for students of Pharmacy,

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FIRST SEMESTER

THEORY

BPM105

BIOLOGY

Max. Marks: 40;Pass percentage: 40;Hrs/ wk: 1+1 (L+T);Duration of exam: 3 hrs



UNIT I

1. Methods of classification of plants.

UNITII

2. Plant Cell: Its structure and non living inclusions: mitosis and meiosis; different types of plant tiss

and their functions.

UNITIII

3. Morphology and histology of root, stem, bark, wood, leaf, flower, fruit and seed, Modification of root

stem.

UNITIV

4. General survey of animal kingdom; Structure and life history of parasites as illustrated by amoe

antanoeba, trypanosoma, plasmodium, taenia, ascaries, schistosoma, oxyuris, and ancylostoma.

UNITV

5. General structure and life history of insects like mosquito, housefly, mites and silkworm.


1. A.C.DuttaBotany for degree studentsOxford.

2. Marshall & WilliamsText Book of ZoologyCBS Publishers & Distributors, New Delhi.

3. FahnPlant AnatomyAdsitya Books private Limited, New Delhi.

4. Weiz B. PaulLaboratory Manual in science of BiologyMc Graw- Hill Book Company.

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FIRST SEMESTER

PRACTICAL

BPM151

PHARMACEUTICAL CHEMISTRYI [INORGANIC CHEMISTRY]

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3;Duration of exam: 4 hrs

Experiments related to the following:

1. The background and systematic qualitative analysis of Inorganic mixtures containing upto 4 radicals.

2. Quantitative analysis of Inorganic compounds.

3. Limit tests for impurities in Pharmaceutical compounds.

4. Preparation and Purification of selected Inorganic Pharmaceutical substances.

NOTE:Any other experiment(s) may be included in support of theoretical aspects of the course.

Distribution of Marks:

1. Experiments : 50 marks

2. Record : 10 marks

3. Viva voce : 10 marks

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FIRST SEMESTER

PRACTICAL

BPM152

PHARMACEUTICAL CHEMISTRYII [ANALYTICAL CHEMISTRY]

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3;Duration of Exam.4 hrs


1. Standardization of analytical weights and calibration of volumetric apparatus.

2. Acid Base Titrations: Preparation and standardization of acids and bases; some exercises related

determination of acids and bases separately or in mixture form some official assay procedures e.g. b

acid shall also be covered.

3. Oxidation-Reduction Titrations: Preparation and standardization of some redox titrants e.g. Potass

permangnate, potassium dichromate, iodine, sodiumthiosulphate etc., Some exercises related

determination of oxidizing and reducing agents in the sample shall be covered. Exercises involv

potassium iodate, potassium bromate, Iodine solution, titanous chloride, sodium 2, 6- dichlorophe

indophenol, & cerric ammonium sulphate be designed.

4. Precipitation Titrations: Preparation and standardization of titrants like silver nitrate and ammon

thiocyanate, titration according to Mohars, Volhards and Fazans methods.

5. Gravimetric analysis: Preparation of Gooch crucible for filtration and use of sintered glass crucib

Determination of water of hydration; some exercises related gravimetric analysis shall be covered.






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FIRST SEMESTER

PRACTICAL

BPM153

PHARMACEUTICAL CHEMISTRYIII [ORGANIC CHEMISTRYI]



1. Introduction to various laboratory techniques viz. recrystallization, distillation, sublimation, thin la

chromatography etc.

2. Simple organic preparations involving acetylation, benzylation, substitutions, sulphonation, oxidation

reduction reactions.

3. Identification of simple organic compounds and preparation of suitable simple derivatives.






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FIRST SEMESTER

PRACTICAL

BPM154

BIOLOGY



1. Morphology of plant parts indicated in theory.

2. Care, use and type of microscopes.

3. Gross identification of slides of structure and life cycle of lower plants, animals mentioned in theory.

4. Preparation, microscopic examination of stem, root and leaf of monocot and dicot plants.

5. Structure of human parasites and insects mentioned in theory with the help of specimens.

Note:Any other experiment (s) may be included in support of theoretical aspects of the course.






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SECOND SEMESTER 1

THEORY

BPM201

PHARMACOLOGYI [HUMAN ANATOMY & PHYSIOLOGY]

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1(L+T);Duration of exam: 3 hrs

Instructions to examiners: Two questions would be asked from each unit. Students shall be

required to attempt one question from each unit. In all, five questions shall be attempted. All

questions shall be of 14 marks each.

A. ANATOMY

1. Histology & Cytology

UNITI

1. Cell components (Structure and Functions)

2. Structural and functional characteristics of tissues

(a) Epithelial

(b) Connective

(c) Muscle

(d) Nervous

2. Skeletal System

1. Structure (gross and microscopic), composition & functions of skeleton

2. Classification of joints

(a) Fibrous

(b) Cartiligenous

(c) Synovial

3. Classification of synovial joints

4. Types of movements of joints

5. Joints of upper 7 lower limb (basic concepts)

3. Lymphoid organs (Structure and functions)

(a) Spleen

(b) Thymus

(c) Lymph node

B. PHYSIOLOGY

1. Membrane transport


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SECOND SEMESTER 2

2. Body compartments

3. Ionic equilibrium and resting membrane potential

4. Neuron action potential

5. Synaptic transmission

6. Excitation-contraction coupling (Skeletal muscles)

UNIT II

A. Renal system

1. Structure (Gross and microscopic) and function of urinary tract

2. Physiology of urine formation

3. Acid-Base balance

4. Clearance

B. DIGESTIVE SYSTEM

1. Structure (Gross and microscopic) of GI tract

2. GI tract secretion; absorption and digestion of food

3. Structure (Gross and microscopic) & functions of

Liver,

Pancreas

Gall bladder

A. RESPIRATORY SYSTEMUNIT-III

1. Structure (Gross and Microscopic) respiratory tract

2. Respiration (Mechanism & regulation)

3. Respiratory volumes and vital capacity

B.ENDOCRINE SYSTEM

Basic anatomy and physiology of pituitary, thyroid, parathyroid, adrenal glands, pancreas, testes,

ovaries, their hormones and functions.

C. REPRODUCTIVE SYSTEM

1. Male reproductive system, structure (gross and microscopic) and functions

2. Female reproductive system, structure (gross and microscopic) and functions

3. Family planning: Contraception, medical termination of pregnancy


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SECOND SEMESTER 3

A. NEUROSCINCE

Central Nervous system

UNIT-IV

1. Anatomy & functions of different parts of brain and spinal cord

2. Neurohormonal transmission in CNS

3. Reflex action

4. Cranial nerves and their functions

5. Electroencephalogram

Autonomic nervous system:

1. Physiology and functions of the autonomic nervous system

2. Mechanism of neurohormonal transmission in ANS

B.SENSE ORGANS

1. Structure (Gross and Microscopic) and functions of

A. Eye (Vision)

B. Ear (Hearing)

C. Nose (smell and equilibrium)

D. skin (Superficial receptors)

E. Taste buds

A. CARDIOVASCULAR SYSTEM

UNIT-V

1. Structure (gross) of heart & blood vessels & circulation

2. Electrical activity of the heart (ECG)

3. Cardiac muscle mechanics (cardiac cycle and heart sounds)

4. Regulation of cardiac output, blood flow & blood pressure

B.HAEMATOPOIETIC SYSTEM

1. Composition and functions of blood and its cellular components

2. Blood groups and their significance

3. Mechanisms of coagulation

4. Parameter for blood donors, procedure of blood collection and storage.

C. FIRST AID

Emergency treatment of


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SECOND SEMESTER 4

1. Shock

2. Burns

3. Poisoning

4. Fractures

5. Snake bites

6. Resuscitation methods


1. Ross & Wilson,Anatomy and Physiology in health and illnessChuchill Livingtone

2. C.C. Chatterjee,Human PhysiologyMedical Allied Agency, Calcutta

3. B.D. ChaurasiaHuman Anatomy, regional & AppliedPart I, II & III. CBS Publishers &

Distributors, New Delhi.

4. C.A. Keele, E. Niel and N. Joels Samson Wrights Applied Physiology Oxford

university Press.

5. N.S. Parmar Health Education and Community Pharmacy CBS Publishers and

Distributors, New Delhi.

6. A.C. Guyton and J.E.HallText Book of Medical Physiology.

7. Grays Human Anatomy, ELBS, London

8. Keel & Neil, Samson Wrights applied PhysiologyWB Saunders company

9. G.J. Tortora and N.P. Anagnodokos Principles of Anatomy & physiology Harper &

Row Publishers, New Delhi.

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SECOND SEMESTER 5

THEORY

BPM202

PHARMACEUTICSI [GENERAL PHARMACY & DISPENSING PHARMACY] Max.

Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1 (L+T);Duration of exam: 3 hrsInstructions to

examiners:Two questions should be asked from each unit. Students shall be required to

attempt one question from each unit. In all, five questions shall be attempted. All


Unit-I

1. Definitions and general dispensing procedures including labeling of dispensed products, ethics,

oath and scope of pharmacy.

2. Introduction to official compendia, with emphasis on Indian Pharmacopoeia, British

Pharmacopoeia and United State Pharmacopoeia.

3. Prescription: Handling of prescription, sources of error in prescription, pharmaceutical Latin

terms used in prescription and their English equivalents.

4. Containers, closures, colours, flavours, sweetening agents, antioxidants and preservatives used

in prescriptions.

Unit-II

5. Incompatibilities: Physical and chemical incompatibilities, methods to overcome inorganic

incompatibilities including incompatibilities of metals and their salts, non-metals, acids, alkalis.6. Extraction and extractives: Various methods of extraction including infusion, decoction,

maceration, percolation and digestion. Preparation of infusion, tinctures, dry and soft extracts.

Unit-III

7. Routes of drug administration: Need of dosage forms, therapeutic consideration in dosage form

designing, routes of drug administration and dosage forms for oral, rectal, parenteral,

epicutaneous, ocular, otic and nasal route.

8. Powder dosage form: Standard powders, sieves and their usage in grading, bulk powders and

divided powders for internal and external use. Special powders including insufflations,

effervescent powders and granules.

9. Emulsions and suspensions: Emulsions: Types, emulsifying gents, manufacturing and

identification of emulsions, creaming and cracking and their prevention.Suspensions: flocculated


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SECOND SEMESTER 6

and non-flocculated suspensions, sedimentation, suspending agents, wetting agents, flocculating

agents.

Unit-IV

10. Suppositories: Ideal requirements, bases, manufacturing procedures, packaging and evaluation

11. Semi-solid dosage forms: Definitions, types, mechanism of drug penetration, factors

influencing penetration, semisolid bases and their selection, general formulation of semisolids,

manufacturing procedure, evaluation and packaging.

Unit-V

12. Pharmaceutical Calculations: Posology, calculation of doses for infants, adults and elderly

patients. Percentage solutions, enlarging and reducing recipes, allegation, alcohol dilutions, proof

spirits, isotonic solutions, displacement value.

13. Principles involved and procedures adopted in dispensing of typical preparations like

mixtures, syrups, elixirs, glycerins, mouth washes, gargles, spirits, nasal drops, ear drops,

aromatic waters, emulsions, creams, suspensions, ointment, powders, paste, mucilages, jellies,

suppositories, lozenges, pills, lotions, liniments, inhalations, paints, sprays, tablet, capsule,

triturates.


1. Remingtons Pharmaceutical Sciences Mack Publishing Company, USA.

2. J.W. Copper & G. Gunn, Tutorial Pharmacy, Pitman Books Ltd. London.

3. S.J. Carter, - Dispensing for Pharmaceutical Students 12th Edition, GBS Publishers &

Distributions.485 Bhola Nath Nagar, Shahdara, Delhi32.

4. Theory and Practice of Industrial Pharmacy. Lachman et.al, Varghese Publishing House,

Hind Rajasthan Building, Dadar, Bombay400014.

5. Bentleys Text Book of pharmaceuitcsVol. I & II. Churchill Livinstone

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SECOND SEMESTER 7

THEORY

BPM- 203

PHARMACEUTICSII [COMPUTER APPLICATIONS]

Max. Marks : 70; Pass Percentage : 40; Hrs/ Wk : 3+1 (L+T); Duration of Exam : 3 Hrs

Instructions to examiners: Two questions should be asked from each unit. Students shall be



UNITI

A Simple Model of Computer, Characteristics of Computer, Problem Solving Using Computers.

Representation of Characters in Computers, Representation of Integers, Representation of

Fractions. Number system: Decimal, Binary, Octal and Hexadecimal numbers and their

arithmetic; Computer Generation and Classification: First, Second, Third, Fourth, Fifth

Generation of Computers.

UNIT- II

Programming Language:Classification machine code, assembly language, high level language,

compiling a HLL Program, fourth generation languages.

Operating Systems:Need of Operating System, Type of Operating systems(single user, multi-

user, batch, multiprogrammed, time sharing), Internal & external commands of MS- DOS,Features of Windows based O.S., creating, copying, deleting and renaming files/ folders.

UNIT- III

Basic Features of C language: Data types, Constants, Variables, I/O functions, Arithmetic

operators, Unary operators, Relational and Logical Operators, the conditional operators, Control

structures of C, Switch Statements.

UNIT- IV

Arrays :Defining an array, processing an array, Arrays and strings.

Functions:Defining and accessing a simple function.

Pointer: Simple concept, Function using pointer type argument(s).


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SECOND SEMESTER 8

UNIT- V

Computers and Communication: Types of Communication, Need For Computer

Communication Networks, Internet and WWW, Use of email, search engine, types of sites.

Applications:Role of computers in Pharmaceutical Industries, Use of computers for maintaining

issue & dispatch record of stocks in Pharma company inventory maintenance.


1. V. Rajaraman- Fundamental of Computers (PHI), 2000.

2. B. B. Gottfried: Programming with C (TMH), 1997.

3. D. Comer, Internet and its working, Pearson Education.

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SECOND SEMESTER 9

THEORY

BPM204

ENVIRONMENTAL STUDIES

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1 (L+T);Duration of Exam: 3 hrs




UNITI

1. The Multidisciplinary nature of environmental studies and eco-system

a) Definition, scope and importance of ecology and environment.

b) The ecological components

i. Abiotic components-soil, water light, humidity and temperature

ii. Biotic components and their relationships- symbiosis, mutalism,

commensalisms, parasitism, predation and antibiosis.

c) Concept of an eco-system

d) Structure and function of an eco-system

e) Producers, consumers and decomposers.

f) Energy flow in the eco-system

g) Ecological successionh) Food chain, food webs and ecological pyramids.

i) Introduction, types, characteristics, features, structure and function of the following

ecosystem:

i. Forest Eco-system

ii. Aquatic Eco- system (ponds, streams, lakes, river, oceans, estuaries)

iii. Grassland Eco-system

iv. Desert Eco-system

j) Need of public awareness

2. Natural Resources:

UNITII

a) Renewable and non-renewable resources

b) Natural resources and associated problems.


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SECOND SEMESTER 10

i. Forest resources: Use and over-exploitation, deforestation, case studies, timber

extraction, mining, dams and their effects on forest and tribal people.

ii. Water resources: Use and over utilization of surface and ground water, floods, drought,

conflicts over water, dams benefits and problems.

iii. Mineral resources: Use and exploitation, environmental effects of extracting and using

mineral resources, case studies.

iv. Food resources: World food problems, changes caused by agriculture and overgrazing,

effect of modern agriculture, fertilizer-pesticide problems, water logging, salinity, case

studies.

v. Energy resources: Growing energy needs renewable and non-renewable energy

sources, use of alternate energy sources, case studies.

vi. Land resources: Land as a resource; land degradation, man induced landslides, soil

erosion and desertification.

vii. Biodiversity and its conservation: Definition, genetic, species and ecosystem diversity,

value of biodiversity (consumptive use, productive use, social, ethical, aesthetic and

option values)

viii. Biodiversity at global, national and local levels, India as a mega diversity nation, hot

spots of biodiversity. Threats to biodiversity: habitat loss, poaching of wildlife, man

wildlife conflicts. Endangered and endemic species of India. Conservation ofbiodiversity. In-situ and Ex-situ conservation of biodiversity.

ix. Bio-geographical classification of India.

x. Role of individual in conservation of natural resources.

xi. Equitable use of resources for sustainable lifestyles.

UNITIII

3. Environmental Pollution:

i. Definition, causes, effects and control measures of:

a). Air pollution

b). Water pollution

c). Soil pollution

d). Marine pollution

e). Noise pollution


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SECOND SEMESTER 11

f). Thermal pollution

g). Nuclear hazards

ii. Soil Waste Management: Causes, effects and control measures of urban and industrial

wastes.

iii. Role of an individual in prevention of pollution.

iv. Pollution case studies.

v. Disaster management: floods, earthquake, cyclone and landslides.

UNIT IV

Social issues and the environment

a) From unsustainable to sustainable development

b) Urban problems related to energy

c) Water conservation, rain water conservation, rain water harvesting, management.

d) Resettlement and rehabilitation of people: its problems and concerns. Case studies.

e) Environmental ethics: Issues and possible solutions.

f) Wasteland reclamation.

g) Consumerism and waste products.

h) Population growth, variation among nations. Family welfare program.

i) Environment and human health, human rights, value education.

j) HIV/AIDS.k) Role of information Technology in Environment and human health.

l) Case studies.

Environmental Policies and laws:

(i) Salient features of following Acts:

UNITV

a) Environment protection Act. 1986.

b) Air (prevention and control of pollution) Act. 1981.

c) Water (prevention and control of pollution) Act. 1974.

d) Wildlife (protection) Act. 1972.

e) Forest conservation Act. 1980.

f) Issues involved in enforcement of environmental legislation.

g) Public awareness.


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SECOND SEMESTER 12

PRACTICAL

BPM251

PHARMACOLOGYI [HUMAN ANATOMY & PHYSIOLOGY] Max.

Marks: 70;Pass percentage: 40;Hrs/ wk: 3;Duration of Exam.4 hrs


1. Study of human skeleton

2. Study of different systems with help of charts and models

3. Microscopic study of different tissues

4. Estimation of haemoglobin in blood. Determination of bleeding time, clotting time,

RBC count, TLC, DLC, and ESR, Blood group determination.

5. Recording of body temperature, pulse rate and blood pressure, basic understanding ofECG-PQRST waves and their significance.

6. Determination of vital capacity, experiments on spirometry.

7. Analysis of normal and abnormal urine: collection of specimen appearance,

determination of pH, sugar, proteins, urea and creatinine.






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SECOND SEMESTER 13

PRACTICAL

BPM252

PHARMACEUTICSI [GENERAL PHARMACY & DISPENSING PHARMACY]



1. Preparation of at least 20 Pharmaceutical products such as waters, solutions, mixtures,

emulsions, infusions, sprits, tinctures and other official preparations in Indian

Pharmacopoeia.

2. Filling of hard gelatin capsules having different dosages.

3. Introduction to prescription, Latin terms commonly used types of dispensing

preparations.

4. Solid Dosages Forms: Bulk powders, incorporation of different ingredients preparationof different varieties of powders such as powders for internal use effervescent

powders, dusting powders, dentifrices etc.

.NOTE:Any other experiment(s) may be included in support of theoretical aspects of the course.





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SECOND SEMESTER 14




PRACTICAL

BPM- 253

PHARMACEUTICSII [COMPUTER APPLICATIONS]Max. Marks: 70; Pass Percentage: 40; Hrs/ Wk : 3; Duration of Exam : 4 Hrs

Experiments related to the following:1). Use of external commands of DOS2). Use of Ms- Word :Document creation, saving, printing, formatting, table handling and

spell checking, and letter mail and merge.

3). Use of MS- Excel:Creation, Opening, saving and printing of worksheet, Use of formulas,Creation of graphs & charts, protection.

4). Program to find the area of a rectangular.

5). Program to find the simple interest for the given values of principle, rate of interest andtime period.

6). Program to find the compound interest for the given values of principle, rate of interest

and time period.

7). Program to make a simple calculator which can perform basic arithmetic operations.8). Program to find the average of 5 integer numbers.9). Program to find the maximum of four integer numbers using if- statement.

10). Program to find the maximum of four integer numbers using conditional operator.11). Program to find the roots of a quadratic equation.

12). Program to display the following triangle using nested for loops:*

********

****************

************************

13). Program to search an integer item from a list of integer items.14). Program to sort a list of integer numbers.

15). Program to count the number of vowels and blank spaces in a given string.16). Program to find the simple and compound interests by defining two functions.

17). Program to find the area and perimeter of a square by making a single function for that.(Dont use the global variable(s))

18). Program to find the average of n integer numbers.

19). Design a menu- driven calculator program for simple arithmetic operations using switchstatement.

20). Write a program to count the number of words from a string; multiple spaces may be usedbetween two consecutive words.




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SECOND SEMESTER 15

PRACTICAL

BPM254

PROFESSIONAL COMMUNICATION



Objectives:

1. To expose the learners to English sound system and acquire phonetic skill and speech

rhythm.

2. To help the learners use grammar correctly.

3. To train the learners to speak English, clearly, intelligibility and effectively.

4. To equip the learners to compete for a career, and enable them to function effectively in

careers which demand good communicative skills.

Contents:

i) Nonverbal communication

- Use of hands

- Posture of shoulders

- Eye contact

- Weight of the body

- Movement of the body

ii) Applied Phonetics

- Sound of English-consonants and Vowels

- Phonemic Transcription

- Stress, Rhythm and Intonation

Remedial Grammar

- Some useful expression (introduction, greetings etc.) that are used frequently

- Common mistakes in the use of nouns, pronouns, adjectives, adverbs, prepositions and

conjunctions.


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SECOND SEMESTER 16

- Use of the who and whom, much and many, still and yet, so as and so that, make and do

- Tense and their use

- Confusion of participles

- Tag Questions

Reading and Speaking skills, Listening and Speaking skills

- Presentation and addresses

- Group discussions

- Interviews

- Role playing

Reading and Writing skills, Listening and Writing skills

- Letter writing-formal and informal

- Real life social situations

- Curriculum vitae

- Agenda, notice and minutes


1. Total :70 Marks

2. Exercise : 30 Marks

3. Viva Voce : 30 Marks


List of recommended Books (Latest editions unless specified):

1) T. Balsubramaniam.Phonetics for Indian Students, Macmillan Indian Ltd.

2) Jones, Daniel.English Pronouncing Dictionary, Cambridge Univ. Press.

3) Oxford Advanced Learners Dictionary.

4) Taylor, Grant.Conversation practice, Tata Mc grew Hills, New Delhi.

5) F.T.A. Wood.Remedial English Grammar, Macmillan India Ltd.6) Berry, Thomas Elliot. The Most Common Errors in English Usage, Tata Mc grew hills,

New Delhi.

7) N. Krishnaswamy.Modern English, Macmillan India Ltd.

8) Desmond.People Watching.

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THIRD SEMESTER 1

THEORY

BPM301

PHARMACEUTICSIII [PHARMACEUTICAL MICROBIOLOGY]

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1(L+T);Duration of Exam: 3 hrs

Instructions to Examiners: Two questions should be asked from each unit. Students shall be



UNITI

1. General Microbiology: Importance of pharmaceutical microbiology. Eukaryotes &

prokaryotes (Structure of bacterial cell). Morphology and classification of bacteria, viruses,

actinomycetes, recktsieae fungi and spirochetes.2. Nutrition, cultivation, isolation and identification of bacteria and fungi.

UNITII

3. Methods of Sterilization:

a. Physical Methods:Dry heat and moist heat, design of equipment, factors governing

selection of processes. Testing efficiency of sterilizers and their applications.

b. Mechanical Methods:Bacteria proof filtration. Different devices used to retain bacteria

and mechanisms of bacterial filtration. Pore size determination and Bubble pressure

technique.

c. Chemical Methods: Treating with a bactericide, Gaseous sterilization and factors

affecting these methods.

d. Radiation Methods: Ultra violet and ionization radiations. Advantages and

disadvantages, methods of radiations production.

4. Aseptic Techniques:

Sources of contamination and methods of prevention. Water for injection and pyrogenicity.

Evaluation for particular matter, design of aseptic area, laminar flow benches.

5. Antiseptics and Disinfectants:

Definition, factors influencing disinfectants, dynamics of their action and evaluation.

Preservatives and their recommended concentrations.


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THIRD SEMESTER 2

UNIT - III

6. Immunology and Immunological Preparations:

Principles, antigens and haptens, immune system, cellular and humoral immunity,

immunological tolerance, antigen-antibody reactions and their applications. Hypersensitivity,

active and passive immunization, their preparations, standardization and storage.

7. Microbial attack and host defense, virulence and pathogenecity, primary and specific defense

mechanisms of body, infection and its transmission,

UNIT- IV

8. Microbiological Assay of antibiotics, vitamins, amino acids.

9. Sterility testing of pharmaceutical products and equipments.

10. Microbial limit test for pharmaceutical products.

UNITV

11.Fermentation and Industrial Microbiology: Fermentation and its design, Control of

different parameters in Fermentation process. Use of mutagenic agents. Isolation of mutants,

Factors influencing rate of mutation. Preparation and isolation of fermentation products with

special reference to Penicillins, Streptomycines, Tetracyclines, Alcohol, Citric acid and

Vitamin B12(Cyanocobalamin).

12. Genetic Engineering: Transformation, conjugations, transduction, protoplast fusion and gene

cloning and their applications. Development of hybridoma for monoclonal antibodies.

Books recommended (Latest editions):

1. S. J. Carter, Cooper and Gunns Tutorial Pharmacy. Sixth edition, pitman publishing co,

London.

2. M. Furbisher, Fundamentals of Microbiology, 8th

Edition, W. B. Saunders Company

Philadelphia, USA.

3. W. B. Hugo and A. D. Russell, Pharmaceutical Microbiology, Blackwell Scientific

Publications, Oxford.

4. Presscot and Donn, Industrial Microbiology, CBS, Publishers, Delhi.

5. K. K. Kieslich (Editor). Biotechnology, Vol. 6a, Verlag chemic, Basel, Switzerland.

6. M. J. Pcelzar, Reid and Chan, Microbiology, TATA Mc-Graw Hill Publishing, New Delhi.


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THIRD SEMESTER 3

7. S. J. Carter, Cooper and Gunns dispensing for pharmaceutical students, 12th Edition CBS

Publisher & Distributors, 485, Bhola Nath Nagar, Shahdara, Delhi-32.

8. A. Osal, Remingtons Pharmaceutical Sciences, Mack publishing company, Pennsylvania,

U.S.A.

-----------------------------


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THIRD SEMESTER 4

THEORY

BPM302

PHARMACEUTICSIV [PHARMACEUTICAL ENGINEERING OPERATIONS]

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1 (L+T);Duration of Exam. 3 hrs




Unit-I

1. Stoichiometry:Unit processes, material and energy balances, molecular units, mole fraction,

tie substances, gas laws, mole volume, primary and secondary quantities, equilibrium stats rate

processes, steady and unsteady states, dimensionless equations, dimensionless formulae,dimensionless groups, different types of graphic representation

2. Fluid Flow: Types of flow, Reynolds number, Viscosity, Concept of boundary layer, basic

equations of fluid flow, manometers (simple and differential), flow meters (Venturi & Orifice),

valves (Plug cock valve, Globe valve, Gate valve), measurement of flow and pressure

(reciprocating and rotary pumps).

Unit-II

3. Heat Transfer: Concept of heat flow, applications of Fouriers law, source of heat, steam and

electricity as heating media, forced & natural Convection, surface coefficients, heat exchangers,

heat interchangers, steam pressure, solar capacity, Stefan Boltzmann equation, Kirchoffs law.

4. Evaporation:Basic concept of phase equilibrium, factors affecting evaporation, evaporators:

film evaporators, single and multiple effect evaporators.

5. Distillation: Raults law, phase diagrams, volatility, simple, steam and flash distillation,

principles of rectification, McCabe thiele method for calculations of number of theoretical plates,

Azeotropic and extractive distillation, Vacuum distillation, molecular distillation (only basic

concepts)

Unit-III

6. Drying: Moisture content and mechanism of drying, rate of drying and time of drying,

classification and types of dryers (spray dryer, drum dryer, rotating drum dryer, fluidized bed

dryer and tray dryer), sublimation and freeze drying


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THIRD SEMESTER 5

7. Size reduction and size separation:Definition, objectives of size reduction, factors affecting

size reduction, laws governing energy and power requirements of mills including ball mill,

hammer mill, fluid energy mill,

8. Separation:Different techniques of size separation (sieves, sieve shakers, sedimentation tank,

cyclone separators, bag filters).

9. Filtration and centrifugation: Theory of filtration, continuous and baton filters, filter aids,

filter media, industrial filters including filter press, rotary filter, edge filter, factors affecting

filtration, principles of centrifugation, industrial centrifugal filters and centrifugal sedimenters.

Unit-IV

10. Mixing:Theory of mixing, mixing of solid-solid, solid-liquid, liquid-liquid; mixing devices:

propellers, turbines and paddles

11. Crystallization: Characteristics of crystals like purity, size, shape, geometry, habit, forms,

size and factors affecting them, solubility curves and calculation of yields, materials and heat

balances around Swenson walker crystallizer, super saturation theory and its limitation,

Nucleation mechanisms, crystal growth. Study of various types of crystallizers (tank, agitated

batch, Swenson walkers, single vacuum, circulating magma and Krystal crystalizer), caking of

crystals and its prevention.

12. Dehumidification and Humidity control:Principles of humidification, dehumidification, air

conditioning and refrigeration, hygrometric chart & measurement of humidity, equipments for

dehumidification and humidification, application of humidity measurement in pharmacy.

Unit-V

13. Material of Construction: Properties and application of the materials of construction with

special reference to stainless steel and glass, Classification & mechanism of corrosion, factors

affecting, prevention and control.

14. Industrial Hazards and safety Precautions: Mechanical, Chemical, Electrical and dust

hazards, industrial dermatitis, accident records


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THIRD SEMESTER 6

Books recommended (Latest editions):

1. Mc Cable & Smith,Unit Operations of Chemical Engineering.

2. Bedger et. Al.Introduction to Chemical Engineering, McGraw Hill Co.

3. E. Lrown,Unit Operations.

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THIRD SEMESTER 7

THEORY

BPM303

PHARMACOGNOSYI





UNITI

1.Introduction, Development, present status and future scope of Pharmacognosy, different groups

of plants constituents.

2. Classification of Drugs: Morphological, Taxonomical, Pharmacological and chemical

classification.

3. Cultivation, collection, processing and storage of crude drugs: factors influencing

cultivation of medicinal plants. Types of soils and fertilizers of common use. Plant hormones and

their applications. Polyploidy, mutations and hybridization with special reference to the medicinal

plants.

UNITII

4. Study of carbohydrate containing drugs: Biological source, Geographical distribution,

Collection, commercial production, chemical constituents, chemical tests for identity, Substitutes,

adulterants and uses of the following:Gum Acacia,Tragacanth, Sterculia, Guargum and Plantago,

Starch, (wheat, potato, maize and rice).

5. Study of lipids and lipid containing drugs: General methods of extraction of fixed oils,

Biological sources, Chemical constituents, Tests for identity and uses of the following: Arachis

oil, Castor oil,Sesame oil, Cottonseed oil, Almond oil, Olive oil and linseed oil.

UNITIII

6. Study of drugs containing, resins and Resin combinations: Colophony,Podophyllum,

Jalap,Cannabis. Capsicum, Myrrh, Asafoetida, Balsam of Peru, Balsam of Tolu and Benzoin,

Turmeric, Ginger.

7.Study of tannins and tannin containing drugs: Hamamelis, Pale & Black catechu, Ashoka

bark, Arjuna bark, Bahera, Harad andNut meg


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THIRD SEMESTER 8

UNIT- IV

8. Study of Biological sources, Cultivation, Collection, Commercial varieties, Chemical

constituents, Substitutes, Adulterants, Uses, Diagnostic macroscopic and microscopic features and

chemical tests for identity of the following groups of drugs.

a) Glycoside containing Drugs:

i.Saponin Containing Drugs:Glycyrrhiza,Senega and Dioscorea.

ii.Cardioactive Drugs:Digitalis, Squill, Strophanthus and Thievetia.

iii.Anthraquinone Cathartics:Aloe,Senna, Rhubarb and Cascara.

b) Alkaloids Containing Drugs:

i Pyridine piperidine group:Tobacco,Arica, and Lobelia.

ii.Trepan group:Belladonna, Hyoscyamus, Datura and Cocoa.

iii.Quinoline isoquinoline group:Cinchona, ipecac and opium.

iv.Indole group:Ergot, Rauwolfia, Catharanthus, Nux-vomica and physostigma.

v.Indiazole group:Pilocarpus.

vi.Steroidal group:Veratrumand kurchi bark.

vii.Alkaloid amino group:Ephedraand colchicum corm and seeds.

UNITV

9.Study of Drugs from Animal Sources:

i.Cantharides, Mylbaris and Coccus.

ii.Beeswax, Wool fat and Spermaceti.

iii.Shark liver oiland Cod liver oil.

iv. Musk v.

Honey vi.

Gelatin

Note:Italicized drugs would be dealt at primary level (whole Pharmacognosy) while other drugs

would be dealt at secondary level (only source, chemical constituents and uses).

List of books recommended (Latest editions):

1. T. E. Wallis,The Text Book of Pharmacognosy, J. & A. Churchill Lets London.

2. G. E. Treason & W. C. Evans, Pharmacognosy(12 Edition), V Bailiore Findall, London,

1983, Lea Fobiger, Philadelphia.


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THIRD SEMESTER 9

3. V. E. Taylor, Lynn R. Brady, H. E. Robbers, Pharmacognosy(9thEdition), Lea & Fobiger,

Philadelphia, 1988.

4. B. P. J. C. Jackson and D. W. Snowden, Powered Vegetable drugs, Stenley Thorns Ltd,

London 1974.

5. C. K. Atlas and B. K. Kappur, Cultivation and Utilization of Medicinal plants, CSIR, India,

1982.

6. A. Krishnamurthi,The Wealth of India, Vol. I to XI, CSIR, New Delhi, 1968.

7. Iyanger,Powered crude drugs.

8. Kokate C.K, Gokhale S.B Purohit A.PPharmacognosyNirali Prakashan New Delhi.

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THIRD SEMESTER 10

THEORY

BPM304

PHARMACOLOGY - II





UNITI

1. Introduction: Definition, Scope, source of drugs, dosage forms & concept of

receptors, factor modifying action.

2. ADME: Routes of drugs administration, dynamics of absorption, distribution,metabolism and excretion of drugs.

3. Molecular Pharmacology: Molecular mechanisms of drugs action, theories of

receptors, dose response relationship affinity constants, potentiation, antagonism

phenomenon.

UNITII

4. Pharmacology of Autonomic Nervous System: Automatic nerve transmission,

parasympthomimetics, parasympatholytics, sympathomimetics, sympatholytics

ganglion transmission and blockers, neuromuscular blocking agents and antispasticity

drugs.

5. Pathophysiology and drug therapy of Myasthenia gravis.

UNIT - III

6. Local anesthetics:Pharmacological study of various local anesthetic agents.

7. Autacoids:Archidonic acid metabolites, histamine, PAF, bradykinin, 5-HT.

UNIT- IV

8. Pharmacology of Central Nervous System: Synaptic transmission in the CNS.

General anesthetics, sedatives and hypnotics, Opioid analgesics.

UNITV

9. NSAIDs and drugs used in gout, antiepileptics, antiparkinsonian drugs,

psychopharmacological agent, CNS stimulants and hallucinogens.


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THIRD SEMESTER 11

10. Vitamins: Vitamin toxicity. Vitamin-drug interaction, role of vitamins in management

of adverse drug reaction

List of books recommended (Latest editions):

1. B.G. Katzung, Basic and Clinical Pharmacology Lange Medical publication, 1995.

2. A. G. Gilman, L.S. Goodmen, T. W. Rall & F. Murad,. The Pharmacological Basis

Therapytics, Macmillan Publishing Co., Ino, 1996.

3. C. R. Craige and R. F. Stitzel, Modern Pharmacology Little Brown & Co, 1994.

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THIRD SEMESTER 12

PRACTICAL

BPM351

PHARMACEUTICSIII [PHARMACEUTICAL MICROBIOLOGY]


Laboratory experiments related to the following:

1. Preparation and sterilization of aerobic and anaerobic media.

2. Aerobic and anaerobic cultivation of bacteria.

3. Grams staining, acid fast staining and hanging drop preparation.

4. Separation of mixed cultures and maintenance of pure cultures.

5. Microbial viable count in pharmaceutical formulations.

6. Particle count in water for injection.

7. Thermal death time studies.

8. Morphological characteristics of moulds and yeasts.

9. Turbidimetric assay of at least one drug using microbial culture.

10. Bio-Chemistry reactions:

a. Starch Hydrolysis b. Gelatin liquification c. Haemolysis of blood

d. Catalase production e. Fermentation of Carbohydrates (A/g production)

11. Phenol coefficient test for disinfectant.

12. Production of at least one product by fermentation.

13. Biological assay of tetracycline and cyanocobalamin.

14. Test for limit of alkalinity of glass.

15. Test for sterility of Pharmaceutical products as per I.P.

16. Preparation of injections of water, Dextrose, Normal saline and Oily phenol. Carrying out

quality control tests.

17. Microbial limit test for liquid and dry products.

Note:Any other experiment(s) may be included in support of the theoretical aspects of the course.


1. Experiment(s) : 50 marks

2. Record : 10 marks3. Viva voce : 10 marks

-------------------------------


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THIRD SEMESTER 13

PRACTICAL

BPM352

PHARMACEUTICSIV [PHARMACEUTICAL ENGINEERING OPERATIONS]



1. (a) Determination of absolute humidity, Relative humidity, Dew point saturated-volume

and humid heat using psychromotic chart.(b) Determination of dew point using ice & water and to compare it with that obtainedusing psychrometric chart.

2. To compare the efficiencies of simple and differential manometers.

3. To perform Reynoldss experiment and to calculate Reynolds number for laminar, Criticaland turbulent flows.

4. Determination of overall efficiency of steam distillation unit (Aniline/water mixture).5. Determination of overall heat transfer coefficient (HTC) of a distillation unit.

6. To determine rate of flow using water.7. (a) Determination of rate of flow by Venturimeter / Orifice meter.

(b) Determination of coefficient of Venturimeter / Orifice meter.

8. To determine the hardness of water.9. Study of effect of insulating material on loss of heat.

10. To study the effect of factors affecting rate of filtration (pressure, thickness of cake, filteraids, viscosity)

11. To study the effect of viscosity on rate of sedimentation.

12. To determine equilibrium-moisture-content (EMC) of various substances like (a) Kaolin.(b) Talc and (c) Starch.

13. To study the effect of factors affecting rate of drying (surface area, temperature etc.)

14. Study of factors affecting rate of evaporation (temperature, surface area)15. Study to efficiency of number of balls on size reduction in Ball mill.

16. Study of characteristics of crystals, solubility curves of crystals.


Distribution of Marks:1. Experiment(s) : 50 marks

2. Record : 10 marks3. Viva voce : 10 marks

---------------------------------


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THIRD SEMESTER 14

PRACTICAL

BPM353

PHARMACOGNOSYI

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3;Duration of Exam:4 hrs


1. Taxonomic study of some medicinal plants with at least one representative of each of the

families covered in theory (organoleptic examination and physiochemical test of selected

drugs).

2. Use, Care and focusing practices of microscope. Macroscopic examination of diagnostic

principles of individual and mixtures of powered crude drugs: Senna, Stramonium,

Cinchona, Rauwolfia, Liquorice, sphere and Nux vomica.

3. Chemical tests of selected unorganized drugs.4. Test for identification of glycosides, saponins, anthraquinone, steroids, tannins.



1. Experiment(s) : 50 marks



---------------------------------


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THIRD SEMESTER 15

PRACTICAL

BPM354

PHARMACOLOGY - II

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3;Duration of Exam:4 hrs


1. Preparation of different solution for experiments, drug dilutions, common laboratory

anesthetics used in animal study, commonly used instruments in experimental

pharmacology. Some common and standard techniques.

2. To study the effect of hepatic microsomal enzyme inhibitors and induction on the

phenobarbitone sleeping time in mice.

3. Study the dose response relationship, calculation of EC50, dose ratios and affinity

constants.

4. Study of various routes of administration of drugs in mice/rate.

5. Common evaluation techniques of analgesic, anticonvulsants, drug affecting muscle

rigidity, anti-inflammatory, local anesthetics etc.


Distribution of Marks:1. Experiment(s) : 50 marks



---------------------------------


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FOURTH SEMESTER 1

THEORY

BPM401

PHARMACEUTICAL CHEMISTRYIV [PHYSICAL CHEMISTRY]

Max. Marks: 70;Pass percentage: 40;Hrs/ wk: 3+1(L+T);Duration of Exam. 3 hrs




UNITI

1. Liquid State: Classification of physical properties, (Surface tension, Parachor, Viscosity,

Molar viscosity, Rheochor, Refractive index, Molar refractivity, Refrachor, Optical

rotation, Dipole moment only) and their use in determination of Chemical constitution.

2. Adsorption: Basic terms, Physical and Chemical adsorption, Their comparison and factors

influencing them, Types of adsorption curves, Types of Adsorption isotherms,

Freundlichs and Langmuirs adsorption isotherm equations including derivation.

Applications of adsorption in industries, Chromatography indicators.

UNITII

3. Colligative Properties: Osmotic pressure (Definitions, Experimental determination by

Berkley and Hartley method and Townsends method, Vant Hoff theory, Hypertonic,

Hypotonic and Isotonic solutions). Lowering of vapour pressure (Raoultslaw of relative

lowering of vapour pressure, Experimental determination by using Barometer, Manometer,

isoteniscope and Ostwald-Walker method). Ebullioscopy (Elevation of boiling point,

Experimental determination by Landsbergers and Cottrells method). Cryoscopy

(Depression of freezing point, Experimental determination by Beckman and Rasts

methods). Derivation of formulas to be excluded for each colligative property mentioned;

abnormal colligative properties and molecular weights, Vant Hoff factor.

UNITIII

4. Chemical Kinetics: Rate of reaction, Rate constant, Molecularity, Order and pseudo

order. Derivation of elementary zero order and 1st order kinetic equations, Examples and

Characteristics of zero order, 1st

and 2nd

order reactions. Derivation of second order kinetic

equation only when initial concentration of reactants is same, factors influencing the

reaction rate, Rate constant and order of reactions (Elementary idea). Effect of


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FOURTH SEMESTER 2

Temperature, Temperature coefficient, Activation energy and Transition state. Arrhenius

equation.

5. Catalysis: Characteristics of catalyst and catalysis. Intermediate compound formation

theory, Adsorption theory and MichaelisMenten theory (Excluding the formula

derivation), characteristics of enzyme catalysis.

UNITIV

6. Thermodynamics I: Basic terms System, Surrounding, Universe, Types of systems,

Types of processes in thermodynamics, Thermodynamically reversible process, State and

non-state functions, Thermodynamic equilibrium, Thermodynamically spontaneous

processes. Concept of work done, Old and new sign conventions for heat change and work

done. Intrinsic energy, Enthalpy, Free energy and work function. Zeroth law of

thermodynamics, Definition of temperature. 1st Law of thermodynamics different

statements, Derivation of state functions like E and H from 1st

law equation,

Applications of 1st

law including its applications to biological systems, Failure of 1st

law.

7. Thermodynamics II: Different statements of 2nd Law of thermodynamics, Concept of

Entropy, Physical significance of entropy, Criteria for thermodynamically spontaneous

processes. Basic idea of 3rd

law of thermodynamics and its application in calculation of

entropy (Only elementary idea)

UNIT - V

8. Chemical Energetics: Methods to write the Thermo chemical equations, Different ways

to express the heat changes; Heat of reaction, Heat of Formation, Heat of combustion,

Heat of neutralization, Heat of fusion, Heat of vaporization, Heat of sublimation, Heat of

transition, Bond dissociation energy, Heat of atomization, Integral Heat of solution, Lattice

energy, Heat of hydration, Differential Heat of solution, Heat of dilution, Heat of

precipitation, Heat of polymerization. Hesss Law of constan

Gurukul kangri B. Pharm. Syllabus-wef-2013-2014

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