Gangguan Pubertas Kel.ppt 2
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Transcript of Gangguan Pubertas Kel.ppt 2
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PUBERTY
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Precocious Puberty
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ClassificationGnRH dependent (central) : premature reactivation hypothalamus-pituitary-gonad axis increased gonadotropin increased sex steroids (dependent)Usually idiopathicGnRH independent (peripheral): autonomous sex steroid secretion, depressing the hypothalamus-pituitary-gonad axisUsually pathologic
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Classification Variantpremature thelarchepremature adrenarchegynecomastia
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HypothalamusPituitaryGnRHGonadLH/FSHE2 or T(-)H-P-G axis
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HypothalamusPituitaryGnRHGonadLH/FSHSex steroid (-)H-P-G axis in GDPPPrimary
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HypothalamusPituitaryGnRHGonadLH/FSH(-)Extra GonadalH-P-G axis in GIPPSex steroid PRIMARY
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ConclusionNot all pubertal disorders are pathologicEarly increase of sex steroid should be thoroughly investigatedGnRH agonist = drug of choice for GDPP
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LHRHLH/FSHHipotalamusHipofisisTarget Organ(gonad)Sex Steroid Primary defectHipergonadotropik(-)
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LHRHLH/FSHHipotalamusHipofisisTarget Organ(gonad)Sex Steroid Primary defectHipogonadotropik(-)DELAYED PUBERTY
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KESIMPULANPubertas berlangsung menurut stadium, umur tertentuPubertas harus selalu menjadi perhatian orangtua / tenaga kesehatanSetiap tenaga kesehatan dapat mendeteksi kelainan pubertas secara dini dan segera melakukan rujukan