Farmacos hipolipemiantes
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Transcript of Farmacos hipolipemiantes
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FÁRMACOS
HIPOLIPEMIANTES
Farmacología I
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FISIOLOGÍA DE LOS
LÍPIDOS
Prostaglandinas
Ácidos biliares
Hormonas esteroides
Vitamina D
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PERFIL LÍPIDICO
Transportar TG exógenos hasta los
tejidos
VLDL – Transportan TGIDL y LDL – Transportan CT hacia tejidos periféricosHDL – Transportan CT desde los tejidos al hígado
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VALORES NORMALES
LDL <100mg/dl (2,6mmol/L)
TG <150mg/dl (1,7mmol/L)
HDL <40mg/dl (1 mmol/L)
Colesterol total <200 mg/dl (5,18mmol/L)
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COLESTEROL (CT)
Constitución de la MC
Fuente de las hormonas esteroideas
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ÁCIDOS GRASOS
Almacenamiento de energía
Lipolisis en tejido adiposo
Constituyen membranas biológicas de toda célula
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FÁRMACOS
HIPOLIPEMIANTES
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ESTATINAS Farmacodinámica
Inhiben Síntesis de
colesterol
Niveles de ldl
ACTUANHmg-COA
REDUCTA
SA
Ldl Y vldl
NIVELES
PLASMÁTICOS
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Farmacocinética
BHE
B.Placentaria
Oatp2
Difusión
simple
Atraviesan Unen
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Efectos adversos
Gastrointestinal
neurológico
dermatológica
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FIBRATOS Farmacodinámica
Oxidación de ácidos
grasos
Secreción de lp
o Estimulan a la lpl
Degradación de vldl
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Farmacocinética
une
• BHE
• B.Placentari
a
• Vía renal
• Vía biliar
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Efectos adversos
digestivo
neurológicas
Hematológicas
Cutáneas
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ÁCIDO NICOTINICO O
NIACINA
Farmacodinámica
Síntesis hepatica de tg y vldl
Conversión de vldl a ldl
Lipoproteína(a) en 30-40‰%
Hdl en 30‰
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Farmacocinética
uneHígado ⁺ Glicina
Ácido
nicotinuricoActividad
Hipolipemiant
e
Eliminacion ---
orina
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Efectos adversos
digestivo Niveles
plasmáticos
dermatológicas
cardiovascular
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RESINAS
Circulación enterohepática
Vía fecal
Farmacodinámica
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Farmacocinética
o No se absorbe
rápidamente por vía
oral
o No se afectan por los
enzimas intestinales
o La excreción final es
principalmente fecal
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Efectos adversos
gastrointestinales
La absorción de vitaminas
liposolubles
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PROBUCOL
Farmacodinámica
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Farmacocinética
Eliminación
Bilis
Heces
Renal
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Efectos adversos
digestivo
dermatológica
neurológica
hematológica
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Factores de Riesgo
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Ácido nicotínico
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Probucol
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FÁRMACOS ADECUADOS A CADA
HIPERLIPOPROTEINEMIA
El tratamiento de la
enfermedad causal
Mejorar las
alteraciones
lipídicas
La obesidad
Diabetes mellitus
Con dieta hipocalórica Controlada con la insulina
Normalización de los lípidos plasmáticos
Uso del
medicamento
La obesidad
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DIETA A INDICAR EN LAS
HIPERLIPOPROTEINEMIA
Carnes limitadas a 200 g/día
Lácteos restringidos
Todas las frutas y vegetales
Cocinados bajos en grasas
Evitar las grasas sólidas
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