Düsseldorf • Germany Programme · from the famous artist Roy Lichtenstein during the poster...

29th Annual Meeting ofthe Society for VirologyGesellschaft für Virologie e. V.

und

Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.

20–23 March 2019 Düsseldorf • Germany

Programme

© jotily l Fotolia.com

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POSTER SESSION 1Infektionskrankheiten

Röteln-Virus IgG, IgM

Vollautomation zur akkuraten Differentialdiagnose

• Anzahl der Tests: 100• Festphase: Rubella Viruspartikel (Stamm HPV 77)• Markierung: Isoluminol-Derivat• Methode: CLIA• Quantitative Assays• Probentyp: Serum/Plasma• Hoher Durchsatz• Referenz an WHO-Standard: 1. NIBSC Internationaler Standard RUBI-1-94 (1997)

Hauptmerkmale der LIAISON® Rubella-Assays

DiaSorin Deutschland GmbHVon-Hevesy-Straße 3D-63128 DietzenbachTel. +49 (0) 6074 401- 0 Fax +49 (0) 6074 401- 209E-Mail: [email protected] www.diasorin.com

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TABLE OF CONTENTS

Welcome Notes Conference Chair ............................................................................................................. 4 President of the Society for Virology .............................................................................. 5

Organisation and Imprint ....................................................................................................... 6

Societies, Keynote Speakers, Awards and Poster Prize Committee ...................................... 7

Programme Overviews ........................................................................................................... 8

Scientific Programme Wednesday, 20 March ..................................................................................................... 12 Thursday, 21 March ......................................................................................................... 20 Friday, 22 March .............................................................................................................. 28 Saturday, 23 March .......................................................................................................... 36

Poster Sessions Overview .......................................................................................................................... 40 Poster Session 1 ............................................................................................................... 41 Poster Session 2 ............................................................................................................... 60 Poster Session 3 ............................................................................................................... 78

Sponsors ................................................................................................................................. 95

Industrial Exhibition ............................................................................................................... 96

Floor Plan ............................................................................................................................... 97

Media Cooperations .............................................................................................................. 98

General Information .............................................................................................................. 99

Social Programme .................................................................................................................. 100

Index of Invited Speakers, Abstract Authors and Chair Persons ........................................... 101

Infektionskrankheiten

Röteln-Virus IgG, IgM

Vollautomation zur akkuraten Differentialdiagnose

• Anzahl der Tests: 100• Festphase: Rubella Viruspartikel (Stamm HPV 77)• Markierung: Isoluminol-Derivat• Methode: CLIA• Quantitative Assays• Probentyp: Serum/Plasma• Hoher Durchsatz• Referenz an WHO-Standard: 1. NIBSC Internationaler Standard RUBI-1-94 (1997)

Hauptmerkmale der LIAISON® Rubella-Assays

DiaSorin Deutschland GmbHVon-Hevesy-Straße 3D-63128 DietzenbachTel. +49 (0) 6074 401- 0 Fax +49 (0) 6074 401- 209E-Mail: [email protected] www.diasorin.com

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WELCOME NOTE I CONFERENCE CHAIR

Dear colleagues,

It is with great pleasure that we welcome you to the 29th Annual Meeting of the Society for Virology at the Heinrich-Heine-University in Düsseldorf.In continuation of a long tradition the annual meeting of the society covers a broad spectrum of topics in basic and clinical virology and provides a platform for young but also experienced scientists to present their work and to discuss their ideas with colleagues and friends. With more than 550 submitted abstracts this year’s meeting corroborates the enormous scientific interest and great achievements in the field of virology within our society and beyond. To further promote presentations by young scientists we established a novel “Spotlight Session” where outstanding abstracts from the scientific workshops were selected for plenary presenta-tions. This year’s Keynote Lectures by outstanding international experts in the field of virology and viral immunology will complement the scientific program. In this year again, we cordially welcome 30 colleagues form China and here especially Prof. Guo as the President of the Virology Division of the Chinese Society for Microbiology. The University of Duisburg-Essen successfully established a Sino-German Virtual Institute of Virology together with partners from China. Some of the scientific activities within this novel collaborative structure will be presented in a satellite workshop at this meeting. The state capital Düsseldorf situated at the river Rhine provides an attractive environment with a high quality of life. The seventh most populous city in Germany is an international business center and is also proud on its old town notorious for being the “the longest bar in the world”. Düsseldorf is also known for its museums and the academy of fine arts, from which world-known artists as Gerhard Richter, Andreas Gursky, Joseph Beuys and August Macke emerged. Notably, at the annual meeting you will have the opportunity to enjoy original wall paintings from the famous artist Roy Lichtenstein during the poster session. The paintings from 1970 were restored in 2017 and were a gift by Roy Lichtenstein to the University of Düsseldorf when the building was constructed. The Heinrich-Heine-University Düsseldorf is one of the younger higher education institutions in the state of North Rhine-Westphalia. Since 1988 the university carries the name of one of the city’s finest sons: the poet Heinrich Heine. Today around 30,000 students study at a modern campus under conditions ideally suited to academic life. We are looking forward to an inspiring meeting with interesting presentations and fruitful discussions. We are very grateful for the support by numerous sponsors who make this meeting possible and who provide important information on new developments on diagnostic tools and research equipment in the industrial exhibition.We wish you all an enjoyable meeting with great science and plenty of fun.

Jörg Timmon behalf of the local organising committee

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WELCOME NOTE I PRESIDENT OF THE SOCIETY FOR VIROLOGY

Dear Colleagues, dear Participants,

It is my great pleasure to warmly welcome you to Düsseldorf for our 2019 scientific meeting of the Society for Virology (GfV) held together with the “Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten” (DVV). On behalf of our societies I want to specifically greet our inter-national guests. I deeply feel the need to give our special thanks to Professor Jörg Timm and all the members of the local organizing committee for designing such an inspiring programme. Last but not least I want to thank the staff at Conventus for their effort in planning the meeting as well as the sponsors for their much appreciated support.

This year’s venue, the medical and university campus of the Heinrich-Heine-University, testi-fies for the past and the future Düsseldorf as a notable place of research in virology. One line of tradition is represented by Helmut Ruska, who was the first scientist demonstrating “sub-microscopic” structures as viruses by using the electron microscope. Helmut Ruska worked here in Düsseldorf from 1958 onwards, pioneering Electron Microscopy (EM) for many biological and medical applications and creating an EM-based taxonomy of viruses.

Several pleasant news make this year’s annual meeting quite unique. First, the newly founded GfV junior academy for clinical and experimental virology (“ACHIEVE”) has started to offer its tuition activities at this meeting, including a Spring School for students and round table discus-sions with renowned invited plenary speakers. Second, generous donations made it possible to present more young scientists with prices, including the new “Promovendenpreis” provided by the Bernhard and Ingrid Fleckenstein-Stiftung. For this reason we will have an even more exciting ceremonial session with the GfV prize winners on Thursday afternoon, during which Franz Heinz (Vienna) will receive the Loeffler-Frosch-Medal after awarding Andrea Marzi (Hamilton, MT/US) and Steeve Boulant (Heidelberg) of the Loeffler-Frosch-Prize.

I wish you all a scientifically rewarding, memorable meeting and an enjoyable stay in Düsseldorf.

Hartmut Hengel

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ORGANISATION AND IMPRINT

VenueHeinrich-Heine-University DüsseldorfBuilding 23.01Universitätsstraße 140225 Düsseldorf (DE)

Organiser Gesellschaft für Virologie e. V.(GfV, Society for Virology)www.g-f-v.org

Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V. (DVV, German Associati on for the Control of Virus Diseases)www.dvv-ev.de

Conference ChairProf. Dr. med. Jörg TimmHeinrich-Heine-University DüsseldorfInsti tute of Virology

Conference Organisati onConventus Congressmanagement & Marketi ng GmbHMarlen Schiller/Ann-Kathrin SchulteCarl-Pulfrich-Straße 107745 Jena (DE)Phone +49 3641 31 16-358/[email protected]

Design/LayoutLayout krea.ti f-studio UG (haft ungsbeschränkt)Print Polyprint GmbHCirculati on 1,000Editorial deadline 01 March 2019

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SOCIETIES, KEYNOTE SPEAKERS, AWARDS AND POSTER PRIZE COMMITTEE

Executive Committee of the Society for Virology (GfV)President Vice PresidentH. Hengel (Freiburg/DE) R. Bartenschlager (Heidelberg/DE) B. Sodeik (Hanover/DE)

Secretary Treasurer S. Smola (Homburg/Saar/DE) K. Überla (Erlangen/DE)

Advisory BoardS. Becker (Marburg/DE) K. Osterrieder (Berlin/DE)W. Brune (Hamburg/DE) T. Pietschmann (Hanover/DE)U. Dittmer (Duisburg-Essen/DE) E. Puchhammer-Stöckl (Vienna/AT)C. Drosten (Berlin/DE) S. Schneider-Schaulies (Würzburg/DE)U. Greber (Zurich/CH) V. von Messling (Langen/DE)

For more information and for membership application, please visit our website www.g-f-v.org.

Executive Committee of the German Association for the Control of Virus Diseases (DVV)President Vice PresidentH. Fickenscher (Kiel/DE) H. Zeichhardt (Berlin/DE)

Secretary TreasurerU. Helling (Kiel/DE) B. Gärtner (Homburg/Saar/DE)

Keynote Speakers

AwardsLoeffler-Frosch-Award Loeffler-Frosch-MedalS. Boulant (Heidelberg/DE) F. Heinz (Vienna/AT)A. Marzi (Hamilton, MT/US)

Poster Prize CommitteeS. Ciesek (Duisburg-Essen/DE) G. Gerold (Hanover/DE)I. Drexler (Düsseldorf/DE) T. Gramberg (Erlangen/DE)

A. Bowie (Dublin/IE)J. Breuer (London/GB)M. Brinkmann (Braunschweig/DE)D. Brockmann (Berlin/DE)M. Carrington (Frederick, MD/US)S. Jiang (Shanghai/CN)

J. Hauber (Hamburg/DE)P. Klenerman (Oxford/GB)R. Koup (Bethesda, MD/US)T. Mettenleiter (Greifswald – Isle of Riems/DE) J. Sinclair (Cambridge/GB)P. Stäheli (Freiburg/DE)

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PROGRAMME OVERVIEW I WEDNESDAY, 20 MARCH

Track I – The Host Track II – The Clinical View Track III – The Virus

Lecture Hall 3A Lecture Hall 3D Lecture Hall 3C12.30–13.00

p. 1213.00–14.30

p. 12

p. 12 p. 13 p. 14

p. 16 p. 17 p. 18

p. 100

Poster Session 1Adaptive Immunity; Antiviral Therapy and Resistance; Clinical Virology

Diagnostic Methods and Tools

18.45–21.00

19.15–21.30

Opening Ceremony

Coffee Break/Industrial Exhibition14.30–15.15

Plenary Session 1Virus Outbreaks and Prevention

Workshop 1Adaptive Immunity 1

Workshop 2Diagnostic Methods and Tools

Workshop 3Virus Receptors and Entry

Coffee Break/Industrial Exhibition17.15–18.45

Workshop 4Adaptive Immunity 2

Workshop 5Epidemiology and Public Health

Workshop 6Host Cell Modulation and Oncogenesis 1

p. 41

15.15–16.45

Get-Together/Industrial Exhibition

16.45–17.15

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PROGRAMME OVERVIEW I THURSDAY, 21 MARCH


Lecture Hall 3A Lecture Hall 3D Lecture Hall 3C

p. 20 p. 21 p. 22

10.45–12.15

p. 23

12.30–13.30

p. 23

p. 23 p. 24 p. 25

16.45–18.15

p. 2618.15–19.15

p. 26

08.30–10.00

10.00–10.45Coffee Break/Industrial Exhibition

12.15–13.45

p. 60

Laudations and Presentations for the Loeffler-Frosch-Award and -Medal

GfV General Assembly

Lunch Break/Industrial Exhibition

13.45–15.15

Workshop 7Innate Immunity 1

Workshop 8Emerging Viruses and Zoonosis 1

Workshop 9Viral Genome Replication

Plenary Session 2 Adaptive Immunity against Chronic Viral Infection

Lunch SymposiumQIAGEN GmbH

Workshop 10Innate Immunity 2

SGVIVISino-German Virtual Institute of Virology Satellite Symposium

Workshop 11Host Cell Modulation and Oncogenesis 2

Poster Session 2Emerging Viruses and Zoonoses; Structure, Assembly and Egress; Vaccines

Viral Receptors and Entry; Viral Vectors and Gene Therapy

15.15–16.45


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PROGRAMME OVERVIEW I FRIDAY, 22 MARCH


Lecture Hall 3A Lecture Hall 3D Lecture Hall 3C

p. 28 p. 29 p. 3010.00–10.45 10.00–10.45 10.00–10.45Coffee Break/Industrial Exhibition Teaching Material DURC p. 31 Coffee Break/Industrial Exhibition10.45–12.15

p. 31

12.30–13.30

p. 31

13.45–15.15

p. 31

p. 33 p. 34 p. 35

08.30–10.00

12.15–13.45

Poster Session 3Epidemiology and Public Health; Host Cell Factors for Replication

Host Cell Modulation and Oncogenesis; Innate Immunity

17.15–18.45

Lunch Break/Industrial Exhibition

Workshop 17Virus Vectors and Gene Therapy

p. 78

20.00–01.30

15.45–17.15


Social evening and Award Ceremony of the Poster Prizesp. 100

Workshop 16Antiviral Therapy and Resistance

Workshop 15Host Cell Factors for Replication 1

Spotlight Session

Workshop 12Emerging Viruses and Zoonosis 2

Workshop 13Vaccines

Workshop 14Structure, Assembly and Egress

Plenary Session 3Innate Antiviral Immunity

Lunch Symposium MSD Sharp & Dohme GmbH

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PROGRAMME OVERVIEW I SATURDAY, 23 MARCH

Track I – The Host Track II – The Clinical View

Lecture Hall 3A Lecture Hall 3D

p. 36 p. 37

11.15–12.45

p. 3812.45–13.15

p. 38

09.00–10.30


Workshop 18Host Cell Factors for Replication 2

Workshop 19Clinical Virology

Plenary Session 4Novel Antiviral Strategies

Farewell

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SCIENTIFIC PROGRAMME I WEDNESDAY, 20 MARCH

12.30–13.00 Opening CeremonyRoom Lecture Hall 3A

Welcome note by the president of the Society for Virology H. Hengel (Freiburg/DE)

Welcome note by the vice president for Strategic Management and Equal Opportunities at the Heinrich-Heine University K. Pfeffer (Düsseldorf/DE)

President of Virology Division of the Chinese Society for Microbiology D. Guo (Guangzhou/CN)

Welcome note by the conference chair J. Timm (Düsseldorf/DE)

13.00–14.30 Plenary Session 1 – Virus Outbreaks and PreventionRoom Lecture Hall 3AChairs S. Ciesek (Duisburg-Essen/DE), F. Klein (Cologne/DE)

13.00 A complex networks perspective on global disease dynamicsIL 01 D. Brockmann (Berlin/DE)

13.30 Illegal Immigrants – viruses and vectorsIL 02 T. Mettenleiter (Greifswald – Isle of Riems/DE)

14.00 Live VZV vaccine – What has it taught us and how does it work?IL 03 J. Breuer (London/GB)

14.30–15.15 Coffee Break within the Industrial Exhibition

15.15–16.45 Workshop 1 – Adaptive Immunity 1Room Lecture Hall 3AChairs A. Kraft (Hanover/DE), A. Halenius (Freiburg/DE)

15.15 Hepatitis B virus anti-capsid antibodies decorate HBV-producing cells and OP 01 activate FcγRIII-mediated effector responses V. Horner, V. Falcone, P. Kolb, N. Göppert (Freiburg/DE) S. Urban (Heidelberg/DE), E. Corrales-Aguilar (San José/CR), M. Nassal H. Hengel (Freiburg/DE)

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15.30 Endemic Paramyxoviruses induce T-cells that cross-recognise zoonotic OP 02 Nipahvirus R. D. de Vries, A. de Jong, J. Verburgh (Rotterdam/NL) L. Sauerhering (Marburg/DE), R. S. van Binnendijk (Bilthoven/NL) G. Rimmelzwaan, A. Osterhaus (Rotterdam/NL), A. Maisner (Marburg/DE) M. P. Koopmans, R. L. de Swart (Rotterdam/NL)

15.45 Zikavirus antibody response impaired by pre-existing Flavivirus immunityOP 03 S. Malafa, J. Aberle, S. Aberle, D. Haslwanter, I. Medits G. Tsouchnikas (Vienna/AT), P. Cherpillod (Geneva/CH) S. Wölfel (Munich/DE), E. Percivalle (Pavia/IT), F. X. Heinz K. Stiasny (Vienna/AT)

16.00 IFNα subtypes modulate retrovirus-specific CD4+ T-cell responsesOP 04 R.-L. Kaiserling, J. Dickow, U. Dittmer, K. Sutter (Essen/DE)

16.15 CMV Immune escaped drives poor long-term protection upon experimental OP 05 adoptive immunotherapy in mice F. Mbui, L. Borkner, Z. Chaudhry, L. Cicin-Sain (Braunschweig/DE)

16.30 Prevalence of HSV-1 cell-to-cell spread inhibiting antibodies in humansOP 06 M. Alt, S. Wolf, R. Dittrich, M. Dirks, U. Aufderhorst, B. Giebel, O. Witzke U. Dittmer (Essen/DE), R. Lotfi (Ulm/DE), M. Roggendorf (Munich/DE) A. Krawczyk (Essen/DE)

15.15–16.45 Workshop 2 – Diagnostic Methods and ToolsRoom Lecture Hall 3DChairs N. Fischer (Hamburg/DE), A. Walker (Düsseldorf/DE)

15.15 Three-dimensional co-cultivation of cells from different species and tissue OP 07 origin in a novel bioprinted array as a diagnostic tool for virus detection F. Schwarz, R. Koban, M. Neumann, S. Bürge, T. Lam, L. Kloke H. Ellerbrok (Berlin/DE)

15.30 Recombinant Fc receptors as a versatile platform technology for the OP 08 development of highly sensitive and specific diagnostic tests P. Emmerich (Hamburg, Rostock/DE), A. Mika, A. Rackow, C. Ehmen R. von Possel (Hamburg/DE), R. Medialdea-Carrera (Liverpool/GB), D. Brown A. M. Bispo de Filippis, P. C. d. Sequeira R. M. Ribeiro Nogueira (Rio de Janeiro/BR), B. Halili, X. Jakupi, L. Berisha S. Ahmeti, K. Sherifi (Prishtina/KX), J. Schmidt-Chanasit, H. Schmitz C. Deschermeier (Hamburg/DE)

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15.45 A pan-genotyping Hepatitis C virus NS5A amplification method for reliable OP 09 genotyping and resistance testing K. S. C. Ennker, N. Lübke (Düsseldorf/DE), R. Kaiser (Cologne/DE), A. Walker J. Timm (Düsseldorf/DE)

16.00 ZIKV patient IgM/IgG response patterns in dengue-endemic countries OP 10 determined by novel accurate Zikavirus ICB antibody assays C. Ehmen (Hamburg/DE), R. Medialdea-Carrera (Liverpool/GB), D. Brown A. M. Bispo de Filippis, P. C. d. Sequeira R. M. Ribeiro Nogueira (Rio de Janeiro/BR), J. Schmidt-Chanasit P. Emmerich, A. Rackow, C. Deschermeier, A. Mika (Hamburg/DE)

16.15 Clinical validation of a novel ELISpot-based in vitro diagnostic assay: OP 11 Monitoring cytomegalovirus-specific cell-mediated immunity and risk stratification in hematopoietic stem cell transplant recipients D. Wolff (Regensburg/DE), E. Wagner, D. Teschner (Mainz/DE), C. Wolschke D. Janson (Hamburg-Eppendorf/DE), K. Schaefer-Eckart J. Gaertner (Nürnberg/DE), S. Mielke (Würzburg/DE; Stockholm/SE) M. Schreder (Vienna/AT; Würzburg/DE), G. Kobbe M. Kondakci (Düsseldorf/DE), S. Klein, D. Heidenreich S. Kreil (Mannheim/DE), I. Hilgendorf, M. von Lilienfeld-Toal (Jena/DE) M. Verbeek, S. Grass (Munich/DE), M. Ditschkowski, T. Gromke (Essen/DE) M. Koch (Hamburg-Eppendorf, Mainz/DE), T. Huenig (Würzburg/DE) M. Lindemann (Essen/DE), T. Schmidt, A. Rascle, H. Guldan, S. Barabas R. Wagner, L. Deml (Regensburg/DE)

16.30 Technical capabilities and limitations of fully automated, random access OP 12 processing of a laboratory developed (“in house”) Coronavirus real time PCR on the Hologic Panther Fusion system A. Cordes, A. Heim (Hanover/DE)

15.15–16.45 Workshop 3 – Virus Receptors and EntryRoom Lecture Hall 3CChairs G. Gerold (Hanover/DE), A. Hahn (Göttingen/DE)

15.15 Human Cytomegalovirus glycoprotein B variants affect viral entry, cellOP 13 fusion and genome stability J. Tang, E. Ostermann (Hamburg/DE), R. Lebbink (Utrecht/NL) W. Brune (Hamburg/DE)

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15.30 Cellular interactions that facilitate nuclear import of human Papillomavirus OP 14 type 16 during mitosis K.-Y. Lai, I. Aydin, M. Rizzato, R. Villalonga-Planells, H. Drexler M. Schelhaas (Münster/DE)

15.45 The promiscuous virus – Filoviruses use redundant cell surface proteins for OP 15 productive entry regardless of the cellular background F. Zapatero-Belinchon (Hanover/DE), E. Dietzel, O. Dolnik (Marburg/DE) K. Döhner (Hanover/DE), R. Costa (Hanover, Essen/DE), B. Hertel B. Veselkova, J. Kirui, A. Klintworth, M. P. Manns (Hanover/DE) S. Pöhlmann (Göttingen/DE), T. Krey (Hanover/DE), S. Ciesek (Essen/DE) G. Gerold (Hanover/DE; Umeå/SE), B. Sodeik (Hanover/DE) S. Becker (Marburg/DE), T. von Hahn (Hanover/DE)

16.00 Impact of naturally occurring polymorphisms in dipeptidyl peptidase 4 on OP 16 host cell entry of MERS-coronavirus H. Kleine-Weber, S. Pöhlmann, M. Hoffmann (Göttingen/DE)

16.15 Influenza A viruses use multivalent sialic acid clusters for cell binding and OP 17 receptor activation C. Sieben (Lausanne/CH), E. Sezgin, C. Eggeling (Oxford/GB) S. Manley (Lausanne/CH)

16.30 The phosphatidylserine receptor TIM-1 is an entry factor for Chikungunya OP 18 virus J. Kirui, L. Lasswitz, R. Moller, S. Franz, C. Goffinet (Hanover/DE) G. Simmons (San Francisco, CA/US), T. Pietschmann (Hanover/DE) G. Gerold (Hanover/DE; Umeå/SE)


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17.15–18.45 Workshop 4 – Adaptive Immunity 2Room Lecture Hall 3AChairs S. Tao (Düsseldorf/DE), A. Krawczyk (Duisburg-Essen/DE)

17.15 Interleukin-1β activates essential checkpoints in the formation of OP 19 lung-resident memory T-cells D. Lapuente, J. Fuchs, C. Maier (Erlangen/DE) M. Storcksdieck genannt Bonsmann, A. Maaske, V. Stab, V. Heinecke K. Liedke, R. Heß (Bochum/DE), A. M. Westendorf, W. Bayer (Essen/DE) C. Ehrhardt (Münster/DE), M. Tenbusch (Erlangen, Bochum/DE)

17.30 T-lymphocyte homing in human Ebola and Lassa virus infectionOP 20 J. Port (Hamburg/DE), P. Ruibal (Hamburg/DE) E. Speranza (Boston, MA/US), D. Wozniak (Hamburg/DE) Y. Ighodalo (Irrua/NG), J. Müller, S. Günther, L. Oestereich C. Muñoz-Fontela (Hamburg/DE)

17.45 The influence of complement C3 on regulatory T-cell responses in a mouse OP 21 retrovirus model J. A. Ross (Essen/DE), Z. Banki, D. Bichler, H. Stoiber (Innsbruck/AT) U. Dittmer (Essen/DE)

18.00 Checkpoint inhibitor therapy in persistent viral infection result in a more OP 22 oligoclonal virus-specific CD8+ T-cell receptor (TCR) repertoire S. Klein, I. Prinz, M. Manns, M. Cornberg, A. Kraft (Hanover/DE)

18.15 HCV neutralising antibody responses in natural infections mapped by OP 23 metric multi-dimensional scaling reveals new insights into HCV antigenicity and broadly neutralising antibodies D. Bankwitz (Hanover/DE), A. Bahai (Braunschweig/DE) T. Khera (Essen, Hanover/DE), C. Ginkel (Hanover/DE) D. Todt (Bochum, Hanover/DE), M. Doepke (Hanover/DE), L. Dold F. Klein (Cologne/DE), A. McHardy (Braunschweig/DE) T. Pietschmann (Hanover/DE)

18.30 Catching the escapees – MHC class I allotype specific targets of the Human OP 24 Cytomegalovirus (HCMV) glycoprotein US10 C. Gerke, M. Schwarzmüller, H. Hengel, A. Halenius (Freiburg/DE)

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17.15–18.45 Workshop 5 – Epidemiology and Public HealthRoom Lecture Hall 3DChairs A. Mankertz (Berlin/DE), J. Wenzel (Regensburg/DE)

17.15 Stronger increase of HPV-associated oropharyngeal squamous cell OP 25 carcinoma in women than in men in Germany S. Lohse, B. Berkó, J. Oppermann, J. Küttten, F. Bochen, M. Linxweiler B. Schick (Homburg/Saar/DE), B. Holleczek (Saarbrücken/DE), J. Rissland S. Smola (Homburg/Saar/DE)

17.30 Molecular and epidemiological investigations of an upsurge in paediatric OP 26 Parechovirus infections in Freiburg, Germany, July to August 2018 S. Böttcher (Berlin/DE), R. Elling, F. du Bois, A. Müller (Freiburg/DE) C. Prifert, B. Weissbrich (Würzburg/DE), J. Hofmann (Berlin/DE) K. Korn (Erlangen/DE), A. M. Eis-Hübinger (Bonn/DE), M. Hufnagel M. Panning (Freiburg/DE)

17.45 Zoonotic transmission and pandemic potential of H7N9 virusesOP 27 Y. Shu (Guangzhou/CN)

18.00 Near real-time forecasting of local Usutuvirus transmission in GermanyOP 28 R. Lühken, D. Cadar (Hamburg/DE), N. Becker (Speyer/DE) U. Ziegler (Greifswald – Isle of Riems/DE), L. Lachmann (Berlin/DE) J. Schmidt-Chanasit (Hamburg/DE)

18.15 Fatal encephalitis caused by zoonotic Borna disease virus 1 (BoDV-1) OP 29 infections H.-H. Niller, K. Angstwurm (Regensburg/DE) D. Rubbenstroth (Greifswald – Isle of Riems, Freiburg/DE) K. Schlottau (Greifswald – Isle of Riems/DE), S. Wunderlich (Munich/DE) B. Banas (Regensburg/DE), A. Ebinger (Greifswald – Isle of Riems/DE) S. Giese (Freiburg/DE), L. Forth, D. Hoffmann D. Höper (Greifswald – Isle of Riems/DE), M. Schwemmle (Freiburg/DE) D. Nobach, C. Herden (Giessen/DE), D. Tappe J. Schmidt-Chanasit (Hamburg/DE), C. Brochhausen M. J. Riemenschnieder (Regensburg/DE), G. Rieder M. Errath (Traunstein/DE), B. Neumann, K. Fuchs, R. Linker, J. Wenzel U. Reischl, W. Jilg, A. Gessner, J. Jantsch (Regensburg/DE) M. Beer (Greifswald – Isle of Riems/DE), B. Schmidt (Regensburg/DE)

18.30 Oral HPV-infection in HIV-positive men who have sex with menOP 30 U. Wieland, M. Hellmich (Cologne/DE), A. Potthoff N. Brockmeyer (Bochum/DE), S. Silling (Cologne/DE), A. Kreuter (Oberhausen/DE)

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17.15–18.45 Workshop 6 – Host Cell Modulation and Oncogenesis 1Room Lecture Hall 3CChairs T. Gramberg (Erlangen/DE), B. Walch-Rückheim (Homburg/Saar/DE)

17.15 The HTLV-1 oncoprotein Tax employs NF-κB signals to augment its protein OP 31 stability S. Millen, L. Wolf, T. Göttlicher, S. Schmitt, B. Fleckenstein A. K. Thoma-Kress (Erlangen/DE)

17.30 Human TRIM5α senses and blocks the replication of LINE-1 retroelementsOP 32 B. Volkmann, S. Wittmann, K. Eissmann, J. J. Ross, T. Gramberg (Erlangen/DE)

17.45 Differential regulation of tumor-promoting S100A8/A9 factors by human OP 33 Papillomavirus oncoproteins and the microenvironment in cervical carcinogenesis M. Podgórska, J. Fischbach, K. Knerr-Rupp, J. Treitz, A. Marthaler J. Weisshaar, K. Metzger, Y.-J. Kim, R. M. Bohle, C. S. L. Müller, R. Ströder I. Juhasz-Böss, E.-F. Solomayer, S. Smola (Homburg/Saar/DE)

18.00 The E6 oncogene of HPV8 targets the protein tyrosine phosphatase H1 OP 34 (PTPH1) which supports proliferation of keratinocytes G. Steger, S. Taute, P. Böhnke, S. Buchholz, M. Hufbauer B. Akgül (Cologne/DE)

18.15 Discovery and characterisation of human oncogenic Gammaherpesvirus OP 35 circular RNAs T. Toptan, B. Abere, M. A. Nalesnik, S. H. Swerdlow, S. Ranganathan, N. Lee K. H. Shair, P. S. Moore, Y. Chang (Pittsburgh, PA/US)

18.30 Manipulation of host chromatin by Kaposi’s sarcoma-associated OP 36 Herpesvirus J. Fröhlich, T. Günther, M. Spohn, A. Grundhoff (Hamburg/DE)

18.45–21.00 Get-together within the Industrial Exhibition (see page 100) 19.15–21.30 Poster Session 1Room Roy Lichtenstein-Foyer Building 22.01

Adaptive Immunity, Antiviral Therapy and Resistance, Clinical Virology, Diagnostic Methods and Tools, Viral Genome Replication

(Please refer to page 40 to take a look at the poster session overview.)

DIE ALINITY-FAMILIE IST JETZT KOMPLETT!

CHOOSE TRANSFORMATION

Klinische Chemie • Immunoassay • Hämatologie Blutspenderscreening • Molekulardiagnostik Point of Care • Professionelle Dienstleistungen

2018AM-DE-001v1

19


DIE ALINITY-FAMILIE IST JETZT KOMPLETT!

CHOOSE TRANSFORMATION

Klinische Chemie • Immunoassay • Hämatologie Blutspenderscreening • Molekulardiagnostik Point of Care • Professionelle Dienstleistungen

2018AM-DE-001v1

20

SCIENTIFIC PROGRAMME I THURSDAY, 21 MARCH

08.30–10.00 Workshop 7 – Innate Immunity 1Room Lecture Hall 3AChairs K. Sutter (Duisburg-Essen/DE), C. Thöns (Düsseldorf/DE)

08.30 Convergent evolution of HLA-C down-modulation in human and simian OP 37 immunodeficiency viruses K. Hopfensperger, F. Kirchhoff, D. Sauter (Ulm/DE)

08.45 Regions- and cell-type-specific regulation of type I interferon in the central OP 38 nervous system protects from tick-borne encephalitis virus infection S. Schreier (Magdeburg/DE), L. Zegenhagen (Braunschweig/DE) A. Överby (Umeå/SE), A. Kröger (Magdeburg, Braunschweig/DE)

09.00 Live-cell imaging reveals a potent block of human Cytomegalovirus IE gene OP 39 expression by the chromatin remodeling factor SPOC1 A. Reichel, A.-C. Stilp, M. Scherer (Ulm/DE), N. Reuter S. Lukassen (Erlangen/DE), B. Kasmapour (Braunschweig/DE) S. Schreiner (Munich/DE), L. Cicin-Sain (Hanover, Braunschweig/DE) A. Winterpacht (Erlangen/DE), T. Stamminger (Ulm/DE)

09.15 Analysis of invariant natural killer T-cells in Hepatitis C Virus infectionOP 40 T. Senff, C. Menne, C. Thöns (Düsseldorf/DE), N. Scherbaum (Essen/DE) G. Lauer (Boston, MA/US), J. Timm (Düsseldorf/DE)

09.30 NK cells regulate liver sinusoidal endothelial cells to promote the OP 41 HBV-specific T-cells response Y. Du (Wuhan/CN; Essen/DE), S. Zou (Wuhan/CN) E. Littwitz-Salomon (Essen/DE), M. Han, J. Li, S. Huang, J. Liu, B. Wang X. Zheng (Wuhan/CN), U. Dittmer, M. Lu (Essen/DE), D. Yang J. Wu (Wuhan/CN)

09.45 Interconnection of type I and III interferon-mediated signaling uniquely OP 42 influences the antiviral protection in human intestinal epithelial cells C. Guo, K. Pervolakari, D. Albrecht, M. Stanifer, S. Boulant (Heidelberg/DE)

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08.30–10.00 Workshop 8 – Emerging Viruses and Zoonosis 1Room Lecture Hall 3DChairs S. Junglen (Berlin/DE), A. Groseth (Greifswald – Isle of Riems/DE)

08.30 Characterisation of the interaction between the Ebolavirus and the nuclear OP 43 RNA export factor NXF1 L. Wendt, T. Hoenen (Greifswald – Isle of Riems/DE)

08.45 A MERS-coronavirus variant that emerged during the Korean outbreak wasOP 44 partially resistant against antibody-mediated neutralisation H. Kleine-Weber, M. T. Elzayat, M. Hoffmann, S. Pöhlmann (Göttingen/DE) L. Wang, B. S. Graham (Bethesda, MD/US), M. A. Müller C. Drosten (Berlin/DE)

09.00 A global screen of interferon-stimulated genes revealed LY6E as potent OP 45 antiviral restriction factor S. Pfänder (Bern/CH), K. B. Mar (Dallas, TX/US) E. Michailidis (New York, NY/US), A. Kratzel, D. Hirth, N. Ebert P. V‘Kovski, H. Stalder (Bern/CH), H. H. Hoffmann M. Saeed (New York, NY/US), R. Dijkman (Bern/CH) J. W. Schoggins (Dallas, TX/US), G. Zimmer (Bern/CH) C. M. Rice (New York, NY/US), V. Thiel (Bern/CH)

09.15 Interferon-γ-Driven iNOS – a molecular pathway to terminal shock in OP 46 Arenavirus hemorrhagic fever M. Remy, M. Sahin (Basel/CH), L. Flatz (Geneva/CH) T. Regen (Mainz/DE), D. Merkler (Geneva/CH), D. Pinschewer (Basel/CH)

09.30 A Tug-of-War between Chikungunyavirus and cellular IFITM restriction OP 47 factors S. Franz (Hanover/DE), T. Zillinger (Bonn/DE), S. Dapa, K. Döhner B. Sodeik (Hanover/DE), C. Goffinet (Berlin, Hanover/DE)

09.45 Antiviral immune studies of bats – natural reservoir hosts of emerging OP 48 infectious diseases P. Zhou (Wuhan/CN)

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08.30–10.00 Workshop 9 – Viral Genome ReplicationRoom Lecture Hall 3CChairs M. Lusic (Heidelberg/DE), S. Taube (Lübeck/DE)

08.30 The DNA Damage Repair Protein XPC acts as a restriction factor for Kaposi OP 49 Sarcoma Herpesvirus lytic replication D. Nivia, G. Mariggiò, S. Koch, M. Weidner-Glunde, G. Zhang T. F. Schulz (Hanover/DE)

08.45 Identification and characterization of avian-adaptive mutations of bat OP 50 influenza A virus chimeras W. Ran (Freiburg/DE), J. Schön, M. Beer D. Hoffmann (Greifswald – Isle of Riems/DE), M. Schwemmle (Freiburg/DE)

09.00 Structure of the cap-binding domain of Rift Valley fever virus L proteinOP 51 N. Gogrefe, S. Reindl, S. Günther, M. Rosenthal (Hamburg/DE)

09.15 Functional regulation of the DNA-repair enzyme FEN1 by the human OP 52 Cytomegalovirus IE1 protein suggests a role for resolution of stalled viral replication forks E.-M. Schilling, M. Scherer, T. Stamminger (Ulm/DE)

09.30 Development and characterisation of an HCV/HEV co-infection modelOP 53 D. Todt (Bochum, Hanover/DE), K. Resner, N. Moeller, L. Knegendorf M. Friesland, P. Behrendt (Hanover/DE), H. Wedemeyer (Essen/DE) E. Steinmann (Bochum, Hanover/DE)

09.45 Hepatitis B virus X (HBx) SUMOylation by the host cell regulates cccDNA OP 54 establishment V. Plank, S. Hofmann, P. Groitl (Neuherberg, Munich/DE) M. Nassal (Freiburg/DE), D. Stadler, U. Protzer S. Schreiner (Neuherberg, Munich/DE)

10.00–10.45 Coffee Break within the Industrial ExhibitionRoom Industrial Exhibition

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10.45–12.15 Plenary Session 2 – Adaptive Immunity against Chronic Viral InfectionRoom Lecture Hall 3AChairs P. Lang (Düsseldorf/DE), A. Westendorf (Essen/DE)

10.45 The impact of immunogenetic variation on HIV diseaseIL 05 M. Carrington (Frederick, MD/US)

11.15 Novel antiviral T-cell responsesIL 06 P. Klenerman (Oxford/GB)

11.45 Engineering HIV neutralising anitbodies to improve antiviral activityIL 07 R. Koup (Bethesda, MD/US)

12.15–13.45 Lunch Break within the Industrial ExhibitionRoom Industrial Exhibition

12.30–13.30 Lunch Symposium – QIAGEN GmbH Room Lecture Hall 3A

New possibilities in infectious disease testing: high throughput routine testing and near patient molecular diagnostics to cover the needs of multiple clinical settings R. Kaiser (Cologne/DE), E. J. Cools (Hilden/DE)

13.45–15.15 Workshop 10 – Innate Immunity 2Room Lecture Hall 3AChairs E.-M. Schilling (Ulm/DE), F. Full (Erlangen/DE)

13.45 Human Myxovirus resistance protein B (MxB) – a novel pan-herpesvirus OP 55 restriction factor S. Weigang (Freiburg/DE), M. Serrero, B. Sodeik (Hanover/DE) G. Kochs (Freiburg/DE)

14.00 Innate sensing of hepatitis B virusOP 56 L. Lauterbach-Rivière, M. Bergez, S. Moench, M. Riess (Langen/DE) B. Qu, S. Urban (Heidelberg/DE), R. Koenig (La Jolla, CA/US; Langen/DE)

14.15 How IFNα subtypes differentially regulate innate immunity to HIVOP 57 J. Ickler, S. Francois, U. Dittmer, K. Sutter (Essen/DE)

14.30 NHL-containing TRIM proteins limit excessive virus-induced autophagyOP 58 L. Koepke, K. Regensburger (Ulm/DE), S. Gableske M. U. Gack (Chicago, IL/US), F. Kirchhoff, K. M. Sparrer (Ulm/DE)

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14.45 ADAR1 controls innate immunity acti vati on by editi ng of endogenous and OP 59 viral duplex RNA structures C. K. Pfaller (Langen/DE; Rochester, MN/US) R. C. Donohue (Rochester, MN/US), S. Nersisyan (Moscow/RU; Haifa/IL) L. Brodsky (Haifa/IL), R. Catt aneo (Rochester, MN/US)

15.00 High-risk human Papillomaviruses suppress chemokines in host OP 60 kerati nocytes but support an infl ammatory microenvironment via NF-κB-signaling in stromal fi broblasts M. Vogelgesang, J. Fischbach, M. Henning, K. Bastuck, R. Ströder I. Juhasz-Böss, E.-F. Solomayer, R. M. Bohle, S. Lohse S. Smola (Homburg/Saar/DE)

13.45–15.15 SGVIVI Room Lecture Hall 3DChairs U. Ditt mer (Essen/DE), D. Yang (Wuhan/CN)

13.45 Selecti on of altered epitope processing is a common immune escape SG 01 mechanism by chronic hepati ti s viruses A. Walker (Düsseldorf/DE)

13.58 An att enuated mouse Cytomegalovirus mutant lacking an interferon SG 02 antagonist mounts immune responses, which confer full protecti on to adult animals and their off spring K. Le-Trilling (Duisburg-Essen/DE)

14.11 SEC14L2, a lipid-binding protein, regulate HCV replicati on in culture with SG 03 inter- and intra- genotype variati ons R. Costa (Duisburg-Essen/DE)

14.24 The intrahepati c microRNA signatures in diff erent natural phases of chronic SG 04 hepati ti s B virus infecti on and identi fi cati on of cell type-specifi c miRNA profi le for liver cells M. Lu (Duisburg-Essen/DE)

14.37 Intravital imaging of regulatory and eff ector T-cells during an acute SG 05 retroviral infecti on L. Ott o (Duisburg-Essen/DE)

14.50 Harnessing new human IFN-α subtype to elicit more potent signaling and SG 06 anti viral eff ectors combati ng Hepati ti s B virus J. Chen (Shanghai/CN)

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15.03 Triggering CD8+ T-cell immunity by liver sinusoidal endothelial cells during SG 07 intrahepatic HBV clearance is HBeAg dependent and is mediated by TNF-α and IL-27 J. Liu (Wuhan/CN)

13.45–15.15 Workshop 11 – Host Cell Modulation and Oncogenesis 2Room Lecture Hall 3CChairs S. Boulant (Heidelberg/DE), J. von Einem (Ulm/DE)

13.45 scSLAM-seq and GRAND-SLAM reveal core features of CMV-induced OP 61 regulation in single cells F. Erhard, M. Baptista, T. Krammer, T. Hennig (Würzburg/DE) M. Lange (Munich, Neuherberg/DE), P. Arampatzi, C. Jürges (Würzburg/DE) F. Theis (Neuherberg, Munich/DE), A.-E. Saliba, L. Dölken (Würzburg/DE)

14.00 Non-endothelial stroma is a major source of latent Cytomegalovirus in the OP 62 spleen K. Sitnik, C. Wiechers, S. Herppich, J. Hühn, L. Cicin-Sain (Braunschweig/DE)

14.15 Low oxygen levels in the human gut influences the barrier and the immune OP 63 functions of intestinal epithelial cells S. Muenchau, R. Deutsch, N. Heber, T. Hielscher, M. Stanifer, B. Niesler S. Boulant (Heidelberg/DE)

14.30 Alternative mRNA polyadenylation modulates influenza A virus induced OP 64 innate immune response V. Bergant, P. Hubel, N. de Andrade Krätzig, T. Engleitner A. Meiler (Munich/DE), D. Schnepf (Freiburg/DE), B. Ryffel (Orléans/FR) R. Rad (Munich/DE), P. A. Knolle (Freiburg/DE), R. Dijkman (Bern/CH) P. Stäheli, G. Kochs (Freiburg/DE), A. Pichlmair (Munich/DE)

14.45 CD137, but not CD134 agonistic therapy in chronically friend virus-infected OP 65 mice mediates FBL-3 tumor cell rejection A. Malyshkina, U. Dittmer (Essen/DE)

15.00 Influenza A virus M2 protein interaction with cellular Na,K-ATPase reduces OP 66 vectorial fluid transport in influenza pneumonia J. Schulze (Berlin/DE), C. Peteranderl, I. Kuznetsova, S. Pleschka S. Herold (Giessen/DE), T. Wolff (Berlin/DE)


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15.15–16.45 Poster Session 2Room Roy Lichtenstein-Foyer Building 22.01

Emerging Viruses and Zoonoses, Structure, Assembly and Egress, Vaccines, Viral Receptors and Entry, Viral Vectors and Gene Therapy

(Pleae refer to page 40 to take a look at the poster session overview.)

16.45–18.15 Laudations and Presentations for the Loeffler-Frosch-Award and -MedalRoom Lecture Hall 3A

16.45 Welcome note by the president of the Society for Virology H. Hengel (Freiburg/DE)

16.46 GfV Award for the best thesis in virology Laudatio by H. Hengel (Freiburg/DE)

16.48 Presentation by L. Bertzbach (Berlin/DE)

16.53 DZIF Award for the best thesis in virology Laudatio by U. Protzer (Munich/DE)

16.55 N. N.

17.00 Loeffler-Frosch-Award – Part 1 Laudatio by P. Stäheli (Freiburg/DE)

17.05 Presentation by S. Boulant (Heidelberg/DE)

17.25 Loeffler-Frosch-Award – Part 2 Laudatio by S. Becker (Marburg/DE)

17.30 Presentation by A. Marzi (Hamilton, MT/US)

17.50 Loeffler-Frosch-Medal Laudatio by R. Bartenschlager (Heidelberg/DE)

17.55 Presentation by F. Heinz (Vienna/AT)

18.15–19.15 GfV General AssemblyRoom Lecture Hall 3A

ZUVERLÄSSIGE SOFORTDIAGNOSE VONINFLUENZA A / B, RSV / ADENO

Verglichen mit dem klassischen Schnelltest wird das Testverfahren mit dem POCT Analysegerät DRI-CHEM IMMUNO AG2 mit einer speziellen Technologie* 100-fach verstärkt*. So ist ein zuverlässiger Viren-Nachweis bereits in einem sehr frühen Krankheitsstadium möglich. In nur 3 Arbeitschritten ist das Ergebnis nach 10 - 15 Minuten sichtbar.

* Die hohe Sensitivität der Silber-Amplifi -kations-Technologie von Fujifi lm wird in wissenschaftlichen Studien bestätigt.

INFOS AUF UNSEREM MESSESTAND-NR. 16

Analysegerät für die Immunologie

27


ZUVERLÄSSIGE SOFORTDIAGNOSE VONINFLUENZA A / B, RSV / ADENO

Verglichen mit dem klassischen Schnelltest wird das Testverfahren mit dem POCT Analysegerät DRI-CHEM IMMUNO AG2 mit einer speziellen Technologie* 100-fach verstärkt*. So ist ein zuverlässiger Viren-Nachweis bereits in einem sehr frühen Krankheitsstadium möglich. In nur 3 Arbeitschritten ist das Ergebnis nach 10 - 15 Minuten sichtbar.

* Die hohe Sensitivität der Silber-Amplifi -kations-Technologie von Fujifi lm wird in wissenschaftlichen Studien bestätigt.

INFOS AUF UNSEREM MESSESTAND-NR. 16

Analysegerät für die Immunologie

28

SCIENTIFIC PROGRAMME I FRIDAY, 22 MARCH

08.30–10.00 Workshop 12 – Emerging Viruses and Zoonosis 2Room Lecture Hall 3AChairs S. Junglen (Berlin/DE), A. Groseth (Greifswald – Isle of Riems/DE)

08.30 Interferon response is essential in containing human pathogenic OP 67 Bourbonvirus, a tick-borne Orthomyxovirus J. Fuchs, T. Straub, M. Seidl, G. Kochs (Freiburg/DE)

08.45 Modulation of HPAIV H5N8 infection in naturally LPAIV -exposed MallardsOP 68 L. Ulrich, S. Köthe, A. Globig, T. Harder M. Beer (Greifswald – Isle of Riems/DE)

09.00 Culex torrentium – a potent vector for the transmission of West Nile virus OP 69 in Central Europe A. Heitmann (Hamburg/DE), S. Jansen (Hamburg, Lübeck, Borstel/DE) R. Lühken, M. Leggewie, M. Helms, M. Badusche (Hamburg/DE) G. Rossini (Bologna/IT), J. Schmidt-Chanasit (Hamburg, Lübeck, Borstel/DE) E. Tannich (Hamburg/DE)

09.15 Rabies virus cell tropism in 3D – comparison of attenuated, lab and field OP 70 strains M. Potratz, V. te Kamp, L. Zaeck, S. Finke (Greifswald – Isle of Riems/DE)

09.30 Characterisation of a previously unknown sandfly-associated Phlebovirus OP 71 with evidence of neutralising antibodies in humans, Kenya D. Tchouassi (Nairobi/KE), M. Marklewitz (Berlin/DE) E. Chepkorir (Nairobi/KE), F. Zirkel (Berlin, Bonn/DE), S. B. Agha, C. C. Tigoi E. Koskei (Nairobi/KE), C. Drosten (Berlin/DE), C. Borgemeister (Bonn/DE) B. Torto (Nairobi/KE), S. Junglen (Berlin/DE), R. Sang (Nairobi/KE)

09.45 Detection of Cosavirus in a patient with acute flaccid paralysis and in OP 72 sewage samples in Germany V. M. Corman, J. Schneider, J. Hofmann, C. Drosten, H.-C. Selinka S. Diedrich, S. Böttcher (Berlin/DE)

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08.30–10.00 Workshop 13 – VaccinesRoom Lecture Hall 3DChairs W. Bayer (Duisburg-Essen/DE), M. Tenbusch (Erlangen/DE)

08.30 In-depth analysis of CD4 T-cell responses to different HIV-1 vaccination OP 73 regimens applied in human clinical trials F. Pissani (Bethesda, MD/US), B. Schulte (Essen/DE) M. Eller (Bethesda, MD/US), B. Schultz (Essen/DE), S. Ratto-Kim M. Marovich (Bethesda, MD/US), P. Tongchaeroen S. Sriplienchan (Bangkok/TH), S. Rerks-Ngarm (Nonthaburi/TH) P. Pitisuttithum (Bangkok/TH), S. Esser (Essen/DE) G. Alter (Boston, MA/US), M. Robb, J. Kim, N. Michael (Bethesda, MD/US) H. Streeck (Essen/DE)

08.45 Locking HIV-1 env trimers impacts titer, breadth and neutralising capacity OP 74 of env-specific antibody responses C. Schmalzl, D. Peterhoff, V. Graßmann (Regensburg/DE) J. McElrath (Seattle, WA/US), G. Tomaras, D. Montefiori (Durham, NC/US) B. Asbach (Regensburg/DE), S. Ding, G. Pantaleo (Lausanne/CH) R. Wagner (Regensburg/DE)

09.00 Development of thermostable Filovirus vaccines based on recombinant OP 75 insect cell expressed subunits A. Lehrer, T. A. Wong, M. Lieberman, L. Medina (Honolulu, HI/US) T. Geisbert (Galveston, TX/US)

09.15 Checkpoint inhibitors as adjuvants for viral vaccinesOP 76 P. Tannig, A. S. Peter, V. Temchura, D. Lapuente, M. Tenbusch K. Überla (Erlangen/DE)

09.30 Successful mucosal vaccination against HPAIV H5N1 with a novel bat OP 77 influenza A virus based chimeric vaccine approach J. Schön (Greifswald – Isle of Riems/DE), W. Ran (Freiburg/DE) D. Hoffmann, M. Gorka (Greifswald – Isle of Riems/DE), M. Juozapaitis M. Schwemmle (Freiburg/DE), M. Beer (Greifswald – Isle of Riems/DE)

09.45 Immunity induced by a measles virus-based Zika vaccine results in fast OP 78 Zikavirus clearance and protects against fetal death C. Nürnberger (Giessen, Marburg, Langen/DE), B. S. Bodmer (Langen/DE) A. H. Fiedler (Giessen, Marburg, Langen/DE) G. Gabriel (Hamburg, Hanover/DE) M. D. Mühlebach (Giessen, Marburg, Langen/DE)

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08.30–10.00 Workshop 14 – Structure, Assembly and EgressRoom Lecture Hall 3CChairs K. Stiasny (Vienna/AT), T. Krey (Hanover/DE)

08.30 Structure of the stem element of the tick-borne encephalitis virus fusion OP 79 protein E and its contribution to post-fusion trimer stabilisation I. Medits (Vienna/AT), A. Rouvinski, M.-C. Vaney, F. A. Rey (Paris/FR) F. X. Heinz, K. Stiasny (Vienna/AT)

08.45 The Orthobunyavirus membrane fusion protein – Structure-based insight OP 80 into function and evolution J. Hellert (Paris/FR), A. Aebischer (Greifswald – Isle of Riems/DE) P. Guardado-Calvo (Paris/FR), M. Beer (Greifswald – Isle of Riems/DE) F. A. Rey (Paris/FR)

09.00 Semiinfectious virions derived from an influenza A virus with modified OP 81 packaging signals do not incorporate ribosomal RNAs in compensation for missing genomic RNAs H. Bolte (Freiburg/DE), A. Pohlmann (Greifswald – Isle of Riems/DE) M. Rosu (Rotterdam/NL), L. Kolesnikova (Marburg/DE) M. Beer (Greifswald – Isle of Riems/DE), M. Schwemmle (Freiburg/DE)

09.15 Coordination of hepatitis C virus (HCV) assembly and release by host OP 82 cellular protein machineries S. Joecks (Hanover, Heidelberg/DE), G. Vieyres (Hanover/DE) A. Frauenstein (Planegg/DE), J. Bruening, G. Gerold (Hanover/DE) R. Brown (Hanover, Langen/DE), L. Kaderali (Greifswald – Isle of Riems/DE) F. Meissner (Planegg/DE), T. Pietschmann (Hanover/DE)

09.30 Chromatin organisation regulates viral egress dynamicsOP 83 V. Aho, S. Mattola, S. Hakanen (Jyvaskyla/FI), J.-H. Chen (Berkeley, CA/US) B. Sodeik (Hanover/DE), C. Larabell (Berkeley, CA/US) M. Vihinen-Ranta (Jyvaskyla/FI)

09.45 Crystal structure of the Kaposi’s sarcoma-associated herpesvirus (KSHV) OP 84 portal-associated pentameric ORF-19 assembly P. Naniima, S. Koch, U. Curth, E. Naimo (Hanover/DE) K. R. Alkharsah (Dammam/SA), L. J. Stroeh, E. Borst, H. Böning M. Messerle, B. Sodeik (Hanover/DE), P. Legrand (Gif-sur-Yvette/FR) T. F. Schulz, T. Krey (Hanover/DE)


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10.00–10.45 Teaching Material – Raising Awareness for DURCRoom Lecture Hall 3D

Dual use research of concern in education. Raising awareness to gain responsibility – Teaching material for members of the GfV L. Brunotte (Münster/DE), J. Bohne (Hanover/DE)

10.45–12.15 Plenary Session 3 – Innate Antiviral ImmunityRoom Lecture Hall 3AChairs I. Drexler (Düsseldorf/DE), H. Streeck (Essen/DE)

10.45 How Herpesviruses fine tune the innate immune responseIL 08 M. Brinkmann (Braunschweig/DE)

11.15 Role of human PYHIN proteins in anti-viral innate immunityIL 09 A. Bowie (Dublin/IE)

11.45 Role of interferon-λ in host defense against InfluenzavirusIL 10 P. Stäheli (Freiburg/DE)

12.15–13.45 Lunch Break within the Industrial Exhibition

12.30–13.30 Lunch Symposium – MSD Sharp & Dohme GmbH Room Lecture Hall 3A

Fallstricke in der CMV-Diagnostik und -Management bei HSCT-Patienten: Was gibt es Neues? R. Kaiser (Cologne/DE), G. Kobbe (Düsseldorf/DE)

13.45–15.15 Spotlight SessionRoom Lecture Hall 3AChairs U. Dittmer (Duisburg-Essen/DE), S. Smola (Homburg/Saar/DE)

13.45 A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SL 01 SAMHD1 J. Deutschmann, A. Schneider (Erlangen/DE), I. Gruska B. Vetter (Berlin/DE), D. Thomas (Frankfurt a. M./DE), M. Kießling A. Herrmann, S. Wittmann (Erlangen/DE), M. Schindler (Tübingen/DE) J. Milbradt (Erlangen/DE), N. Ferreirós (Frankfurt/DE) T. Winkler (Erlangen/DE), L. Wiebusch (Berlin/DE), T. Gramberg (Erlangen/DE)

14.00 Several breakthroughs of resistant Cytomegalovirus during secondary SL 02 letermovir (PREVYMIS) prophylaxis in hematopoietic stem cell transplant recipients D. Michel, M. Michel, A. Schubert, T. Stamminger (Ulm/DE)

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14.15 A protein interaction network of interferon stimulated genes extends the SL 03 innate immune system landscape P. Hubel (Martinsried, Munich/DE), C. Urban, V. Bergang (Munich/DE) W. Schneider (New York, NY/US), A. Stukalov, P. Scaturro (Munich/DE) L. Brunotte (Münster/DE), M. Schwemmle (Freiburg/DE) C. Rice (New York, NY/US), A. Pichlmair (Martinsried, Munich/DE)

14.30 First-In-Human trial – a MVA vector vaccine candidate for Middle East SL 04 respiratory syndrome is safe and immunogenic C. Dahlke, A. Fathi (Hamburg, Braunschweig/DE)

T. Koch (Braunschweig, Hamburg/DE), V. Krähling, A. Kupke, S. HalweC. Rohde, M. Eickmann (Marburg, Braunschweig/DE)

A. Volz (Braunschweig, Munich/DE), T. Hesterkamp (Braunschweig/DE) M. L. Ly, M. E. Zinser, E. Bartels, J. H. S. Poetsch R. Neumann (Hamburg, Braunschweig/DE), R. Fux (Munich/DE), N. Okba B. L. Haagmans (Rotterdam/DE), S. Schmiedel (Hamburg/DE) A. Lohse, M. M. Addo (Hamburg, Braunschweig/DE) G. Sutter (Munich, Braunschweig/DE) S. Becker (Braunschweig, Marburg/DE)

14.45 Knocking at the nuclear door – Rift Valley fever virus virulence factor NSsSL 05 targets nuclear-cytoplasmic transport S. Lau (Giessen, Marburg/DE), A. Weber (Giessen/DE) U. Linne (Marburg/DE), M. Kracht, F. Weber (Giessen/DE)

15.00 Genetically encoded unnatural amino acids in human cells:SL 06 New possibilities to map protein interactions O. M. Olajide, M. Schwemmle (Freiburg/DE)


15.45–17.15 Poster Session 3Room Roy Lichtenstein-Foyer Building 22.01

Epidemiology and Public Health, Host Cell Factors for Replication, Host Cell Modulation and Oncogenesis, Innate Immunity

(Pleae refer to page 40 to take a look at the poster session overview.)

33


17.15–18.45 Workshop 15 – Host Cell Factors for Replication 1Room Lecture Hall 3AChairs C. Goffinet (Hanover/DE), R. König (Langen/DE)

17.15 Analysis of the influence of the host factors NXF1 and CAD on the OP 85 Ebolavirus life cycle J. Brandt, T. Hoenen (Greifswald – Isle of Riems/DE)

17.30 Autophagy as an antiviral defence mechanism is subverted by human OP 86 Cytomegalovirus C. Zimmermann, S. Krauter, N. Krämer, E. Sehn, U. Wolfrum, A. Freiwald F. Butter, B. Plachter (Mainz/DE)

17.45 The impact of guanylate-binding protein 1 on the HCV life cycleOP 87 X. Wen (Langen/DE; Chengdu/CN), F. Elgner, B. Jiang, D. Bender E. Hildt (Langen/DE)

18.00 Glycoprotein G from herpes simplex virus 2 enhances neurite outgrowth OP 88 and facilitates effective infection of DRG sensory neurons K. Kropp (Hanover/DE), A. Domingo (Madrid/ES), B. Ritter S. Srivaratharajan (Hanover/DE), R. Martín, A. Rastrojo (Madrid/ES) J. Czechowicz, C. Henning-Nagel (Hamburg/DE), B. Sodeik (Hanover/DE) A. Alcami (Madrid/ES), A. Viejo-Borbolla (Hanover/DE)

18.15 Perilipin-2 is critical for efficient lipoprotein and Hepatitis C virus particle OP 89 production S. Lassen, C. Grüttner, V. Nguyen-Dinh (Hamburg/DE) E. Herker (Marburg, Hamburg/DE)

18.30 Synaptosomal-associated protein 29 is required for the autophagic OP 90 degradation of hepatitis B virus Y. Lin, X. Wang, T. Kemper, M. Lu (Essen/DE)

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17.15–18.45 Workshop 16 – Antiviral Therapy and ResistanceRoom Lecture Hall 3DChairs N. Lübke (Düsseldorf/DE), A. Schubert (Ulm/DE)

17.15 Identification and characterisation of novel antiviral compounds targeting OP 91 different RSV life cycle steps S. M. Wiechert, S. Trummer, S. Blockus, S. Haid, M. Friesland, J. Rückert C. Grethe, B. Wiegmann (Hanover/DE) T. F. Schulz (Braunschweig, Hanover/DE), W. P. Duprex (Boston, MA/US) M.-A. Rameix-Welti (Montigny-le-Bretonneux/FR) J.-F. Eléouët (Jouy-en-Josas/FR) T. Pietschmann (Hanover, Braunschweig/DE)

17.30 Novel replication assay for archetypal and rearranged BK Polyomaviruses in OP 92 RPTEC and in silico modeling identifies first compound class with direct antiviral effects P. Feld, S. Lohse, M. Sommer (Homburg/Saar/DE) K. M. Götz (Saarbrücken/DE), M. Janssen, M. Stöckle (Homburg/Saar/DE) M. Laue (Berlin/DE), T. Lehr (Saarbrücken/DE), S. Smola (Homburg/Saar/DE)

17.45 Brincidofovir (CMX-001) for refractory Adenovirus infections after stem cell OP 93 transplantation – a single-center experience J. Schulte, P. Hundsdörfer, S. Voigt (Berlin/DE)

18.00 Interim results of a multicentre, open-label phase 2 clinical trial (MYR203) OP 94 to assess safety and efficacy of myrcludex B in combination with peg-interferon alpha 2a in patients with chronic HBV/Hdv co-infection H. Wedemeyer (Hanover/DE), K. Schöneweis (Heidelberg/DE) P. Bogomolov, N. Voronkova, V. Chulanov, T. Stepanova (Moscow/RU) B. Bremer, P. Lehmann, R. Raupach (Hanover/DE), L. Allweiss M. Dandri (Hamburg/DE), S. Cieseck, U. Dittmer (Essen/DE) W. E. Haefeli (Heidelberg/DE), A. Alexandrov (Burgwedel/DE) S. Urban (Heidelberg/DE)

18.15 Small-molecule polymerase inhibitor treatment protects squirrel monkeys OP 95 (Saimiri sciureus) from Measlesvirus K. Wittwer (Langen/DE), D. Anderson (Singapore/SG), K. Pfeffermann R. Plesker (Langen/DE), R. Plemper (Atlanta, GA/US) V. von Messling (Langen/DE)

18.30 Efficacy of novel helicase-primase based therapy for human Herpes simplex OP 96 virus (HSV) in an infection mouse model N. Lindner, J. Krause (Leipzig/DE), G. Kleymann (Bad Salzuflen/DE) T. Grunwald (Leipzig/DE)

35


17.15–18.45 Workshop 17 – Virus Vectors and Gene TherapyRoom Lecture Hall 3CChairs F. Kreppel (Witten-Herdeke/DE), J. Kimpel (Innsbruck/AT)

17.15 Adenoviral vectors for multiplex CRISPR/Cas9 gene editing to treat OP 97 Duchenne Muscular Dystrophy E. Ehrke-Schulz, A. van den Boom, W. Zhang (Witten/DE) V. Mouly (Paris/FR), A. Ehrhardt (Witten/DE)

17.30 Adenoviral vectors armed with HPV oncogene specific CRISPR/Cas9 for OP 98 treatment of cervical carcinoma S. Heinemann, A. Ehrhardt, E. Ehrke-Schulz (Witten/DE)

17.45 A novel oncolytic Vacciniavirus strain with high capacity to kill cancer cells OP 99 and to induce immunogenic cell death of tumors J. J. Rojas, S. Riederer (Munich/DE), L. Van Hoecke, X. Saelens (Ghent/BE) M. Lehmann, G. Sutter (Munich/DE)

18.00 Oncolytic Reovirus overcomes HPV-mediated immune silencing in cervical OP 100 cancer cells, and leads to paracrine dendritic cell activation in a RIPK3-dependent manner B. Walch-Rückheim, M. Ehrhardt, K. Knerr-Rupp, J. Fischbach, N. Graf S. Smola (Homburg/Saar/DE)

18.15 Conditionally cytotoxic and controllable Rhabdoviruses for oncolytic and OP 101 immune stimulatory virotherapy V. Pfaffinger, A. Ghanem, Y. Haddad, K.-K. Conzelmann (Munich/DE)

18.30 Sendai virus vectors efficiently deliver HCMV antigens ex vivo and in vivoOP 102 R. Kiener, M. Fleischmann (Regensburg/DE) M. A. Wiegand (Martinsried/DE), N. Lemmermann (Mainz/DE) C. Schwegler (Regensburg/DE), C. Kaufmann (Martinsried/DE) A. Renzaho (Mainz/DE), S. Thomas (Regensburg/DE) E. Felder (Martinsried/DE), H.-H. Niller, B. Asbach R. Wagner (Regensburg/DE)

20.00–01.30 Social Evening and Award Ceremony of the Poster PrizesRoom Schlösser Quartier Bohème (Please refer to page 100 for more details.)

36

SCIENTIFIC PROGRAMME I SATURDAY, 23 MARCH

09.00–10.30 Workshop 18 – Host Cell Factors for Replication 2Room Lecture Hall 3AChairs L. Brunotte (Münster/DE), C. Münk (Düsseldorf/DE)

09.00 Interferons in the course of Flaviviridae infection:OP 103 Does it make a difference? S. Westhaus, G. Homa (Essen/DE) M. Schwerdtfeger (Essen, Recklinghausen/DE) V. Tharmapalan (Lübeck, Essen/DE), S. Pfänder (Bern/CH), K. Sutter U. Dittmer, S. Ciesek (Essen/DE)

09.15 Merkel cell Polyomavirus DNA replication induces senescence in human OP 104 dermal fibroblasts in a Kap1/Trim28 dependent manner S. Siebels, M. Czech-Sioli, J. Theiss, M. Spohn, T. Günther, A. Grundhoff N. Fischer (Hamburg/DE)

09.30 Gene expression profiling reveals novel Hepatitis C virus host factorsOP 105 C. Dächert, V. Lohmann, E. Gladilin, M. Binder (Heidelberg/DE)

09.45 Transcriptomics landscape of hRSV infected ex vivo primary human airway OP 106 epithelia cells revealed by single-cell RNA-seq S. Haid (Hanover/DE), E. Vafadarnejad (Würzburg/DE) R. Geffers (Braunschweig/DE), B. Wiegmann (Hanover/DE) A.-E. Saliba (Würzburg/DE), T. Pietschmann (Hanover/DE)

10.00 HBV Core protein SUMOylation promotes PML association and chronic OP 107 infection S. Hofmann, V. Plank, P. Groitl, C. Ko (Neuherberg, Munich/DE) M. Nassal (Freiburg/DE), D. Stadler, U. Protzer S. Schreiner (Neuherberg, Munich/DE)

10.15 Profiling the ANP32A splicing landscape to predict influenza A virus OP 108 polymerase host adaptation P. Domingues, D. Eletto (Zurich/CH), C. Magnus (Basel/CH) H. Turkington, O. Zagordi (Zurich/CH), M. Lenk M. Beer (Greifswald – Isle of Riems/DE), S. Stertz, B. Hale (Zurich/CH)

37


09.00–10.30 Workshop 19 – Clinical VirologyRoom Lecture Hall 3DChairs T. Ganzenmüller (Tübingen/DE), H. Holzmann (Vienna/AT)

09.00 Simultaneous absence of two viral proteins in the Alphaherpesvirus OP 109 Pseudorabies virus results in a drastically reduced mortality in mice despite widespread neuroinvasion J. Sehl, J. P. Teifke, B. G. Klupp, J. E. Hoelper T. C. Mettenleiter (Greifswald – Isle of Riems/DE)

09.15 The pathogenesis of measles skin rashOP 110 B. M. Laksono (Rotterdam/NL), P. Fortugno, S. Cordisco (Rome/IT) B. M. Nijmeijer (Amsterdam/NL), S. van Nieuwkoop R. D. de Vries (Rotterdam/NL), T. B. Geijtenbeek (Amsterdam/NL) T. Kuiken (Rotterdam/NL), F. Brancati (Rome/IT) R. L. de Swart (Rotterdam/NL)

09.30 Chronic Sapovirus infections in immunocompromised hostsOP 111 C. Pietsch, U. G. Liebert (Leipzig/DE)

09.45 Torque Tenovirus as new biomarker of immunocompetence in HIV-infected OP 112 patients L. Schmidt, A. Fuchs, B. Jensen, V. Keitel-Anselmino (Düsseldorf/DE) M. Böhm, R. Kaiser (Cologne/DE), J. Timm, N. Lübke (Düsseldorf/DE)

10.00 Biomarker analysis during HCMV-reactivation in lactationOP 113 K. Lazar, T. Rabe, R. Goelz, K. Hamprecht (Tübingen/DE)

10.15 Norovirus evolution during chronic infectionOP 114 S. Q. Afridi, H. Moeini (Munich/DE), R. Beck (Tübingen/DE), K. Haase Z. Usman, D. Frishman, S. Donakonda, U. Protzer, D. Hoffmann (Munich/DE)


38


11.15–12.45 Plenary Session 4 – Novel Antiviral StrategiesRoom Lecture Hall 3AChairs M. Trilling (Duisburg-Essen/DE), E. Steinmann (Bochum/DE)

11.15 Research and development of virus entry inhibitionsIL 12 S. Jiang (Shanghai/CN)

11.45 Antiviral therapy of persistent infection using genome editingIL 13 J. Hauber (Hamburg/DE)

12.15 Novel strategies to target the latent human Cytomegalovirus reservoirIL 14 J. Sinclair (Cambridge/GB)

12.45–13.15 FarewellRoom Lecture Hall 3A

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Quality - Made in Germany

CO incubator C2012

200 litre inner volume

with optional UV decontamination

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with active sterile humidity supply

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Benchtop incubator Labo C-Top

two independent and separate incubation chambers

parameters can be adjusted individually

optimized temperature distribution

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40

POSTER SESSION OVERVIEW

Posters in hard copy will only be displayed during the respective poster session. The electronic versions are available during the whole conference at the ePoster terminals.

The poster exhibition of the hard copy posters is located in the Roy Lichtenstein-Foyer, Building 22.01. It is opposite the congress venue.The ePoster terminals can be found within the industrial exhibition. For further details, please take a look at the floor plan on page 97.

Poster Session 1Wednesday, 20 March I 19.15–21.30

Topics NumbersAdaptive Immunity P 01–P 24Antiviral Therapy and Resistance P 25–P 72, P 356Clinical Virology P 73–P 90Diagnostic Methods and Tools P 91–P 115Viral Genome Replication P 116–P 147

Poster Session 2Thursday, 21 March I 15.15–16.45

Topics NumbersEmerging Viruses and Zoonoses P 148–P 204Structure, Assembly and Egress P 205–P 231Vaccines P 232–P 256Viral Receptors and Entry P 257–P 292Viral Vectors and Gene Therapy P 293–P 296

Poster Session 3Friday, 22 March I 15.45–17.15

Topics NumbersEpidemiology and Public Health P 297–P 307Host Cell Factors for Replication P 308–P 352Host Cell Modulation and Oncogenesis P 353–P 378Innate Immunity P 379–P 443

Poster Exhibition

Roy Lichtenstein-Foyer

Congress Venue

Entrance

Entrance

41

POSTER SESSION 1

Adaptive ImmunityP 01 Interferon-λ enhances adaptive antiviral immunity by boosting TSLP release upon mucosal immunizationL. Ye, D. Schnepf, J. Becker, K. Ebert, Y. Tanriver (Freiburg/DE)V. Bernasconi (Gothenburg/SE), H. H. Gad, R. Hartmann (Aarhus/DK)N. Lycke (Gothenburg/SE), P. Stäheli (Freiburg/DE)

P 02 Coincident Airway Exposure to Low-potency Allergen and Cytomegalovirus Sensitizesfor Allergic Airway Disease by Viral Activation of Migratory Dendritic CellsS. Reuter (Duisburg-Essen/DE), N. A. Lemmermann, J. Maxeiner, J. Podlech (Mainz/DE)H. Beckert (Duisburg-Essen/DE), K. Freitag, D. Teschner, F. Ries (Mainz/DE)C. Taube (Duisburg-Essen/DE), R. Buhl, M. J. Reddehase, R. Holtappels (Mainz/DE)

P 03 Protein structure shapes immunodominance of CD4 T-cell epitopes in human Zika virusinfectionsJ. Aberle, M. Koblischke, K. Stiasny, S. Aberle, S. Malafa, F. X. Heinz (Vienna/AT)

P 04 Immune evasion strategies of HCMV: Functional characterization of the highly polymorphic HCMV Fcγ receptor RL12/gp95K. Hoffmann, J. Brech (Freiburg/DE), E. Mercé-Maldonado, H. Reinhard (Düsseldorf/DE)E. Corrales-Aguilar (San José/CR; Düsseldorf/DE), P. Lacher (Düsseldorf/DE)V. T. K. Le-Trilling (Düsseldorf, Essen/DE), H. Hengel (Freiburg/DE)

P 05 Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the NetherlandsB. Laksono, R. de Vries, J. Verburgh, E. Visser, A. de Jong, P. Fraaij (Rotterdam/NL)W. Ruijs (Bilthoven/NL), D. Nieuwenhuijse, H.-J. van den Ham, M. Koopmans, M. van Zelm A. Osterhaus, R. de Swart (Rotterdam/NL)

P 06 Prolonged exposure to HBV suppresses the induction of efficient HBV-specific immunityafter therapeutic vaccinationA. Kosinska, J. Hareiter, M. Festag, J. Su, P. Knolle, U. Protzer (Munich/DE)

P 07 Investigation into the Ebola virus glycoprotein antigen specific response amongst survivors of the 2014–16 West African outbreakT. Tipton, Y. Hall (Salisbury/GB), M. Martin (Maryland, MD/US), K. Ewer (Oxford, MS/US)M. Carrington (Maryland, MD/US), M. Carroll (Salisbury/GB)

P 08 Analysis of the IgG Response to Ebola Virus Disease (EVD) in a West African CohortJ. Hudson, T. Tipton, Y. Hall (Salisbury/GB), E. Thomson (Glasgow/GB)M. Carroll (Salisbury/GB)

P 09 TLR7 activation enhances the metabolism and functions of CD8+T-cellsL. Qian (Essen/DE), Z. Ejuan (Wuhan/CN), H. Xuan (Guangzhou/CN), M. Lu (Essen/DE), J. Liu D. Yang, H. Yan (Wuhan/CN) J. Hou, X. Zhang (Guangzhou/CN)

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POSTER SESSION 1

P 10 The PD-1/PD-L1 pathway effects the expansion and function of cytotoxic CD8+ T-cells during an acute retroviral infectionP. David (Essen/DE), D. Megger (Bochum/DE), T. Werner, T. Kaiser (Essen/DE)B. Sitek (Bochum/DE), U. Dittmer, G. Zelinskyy (Essen/DE)

P 11 The Fcγ binding glycoprotein gp34 of HCMV antagonizes FcγR activation by soluble immune complexesH. Chen, P. Kolb, H. Hengel (Freiburg/DE)

P 12 Modulation of Memory IgG-B Cells by an Fcγ binding Glycoprotein of human CytomegalovirusP. Cramer (Freiburg/DE), M. Fiedler (Düsseldorf/DE), K. Hoffmann, H. Hengel (Freiburg/DE)

P 14 Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B virus infectionE. Aliabadi (Hanover/DE), C. Mix, M. P. Manns, M. CornbergA. Kraft (Hanover, Braunschweig/DE)

P 15 CD8+ T-cell selection pressure on HBV is predominantly targeted to the core protein and influenced by the HLA class I subtypeT. Schwarz, A. Walker (Düsseldorf/DE), D. Habermann, H. Kefalakes, M. Theissen (Essen/DE) R. C. Hoogeveen (Boston, MA/US), A. Kraft (Hanover/DE)J. Schulze zur Wiesch (Hamburg/DE), M. Maini (London/GB), R. Thimme (Freiburg/DE)H. Wedemeyer (Essen, Freiburg/DE), M. Cornberg (Hanover/DE), G. Lauer (Boston, MA/US)V. Keitel-Anselmino (Düsseldorf/DE), F. M. Heinemann (Essen/DE)C. Neumann-Haefelin (Freiburg/DE), D. Hoffmann (Essen/DE), J. Timm (Düsseldorf/DE)

P 16 Kinetics of APPV specific antibodies during a field infectionG. N. Cagatay, D. Meyer, M. Wendt, P. Becher, A. Postel (Hanover/DE)

P 17 Delivering recombinant antigen by vaccinia B5 as a carrier enhances MVA-induced adaptive immune responses.S. Tao, V. Manokaran, I. Drexler (Düsseldorf/DE)

P 18 IRFE-mediated regulation of mCMV m152 expressionS. Becker, F. Blaum, J. K. Schmiedeke, M. J. Reddehase, N. A. Lemmermann (Mainz/DE)

P 19 Identification of immune escape mutations with a Bayesian logistic regression modelD. Habermann (Essen/DE), T. Schwarz (Düsseldorf/DE), M. Theissen (Essen/DE), A. WalkerJ. Timm (Düsseldorf/DE), D. Hoffmann (Essen/DE)

P 20 Identification of BK polyomavirus derived CD8+ T-cell epitopesC. Menne, T. Senff, O. Adams, J. Timm (Düsseldorf/DE)

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POSTER SESSION 1

P 21 Highly Pathogenic Avian Influenza A (H5N8) virus – from Local to GlobalJ. Chen (Wuhan, Beijing/CN), B. Liang, M. Li, H. Liu (Wuhan/CN), Y. Bi (Beijing/CN), J. SunY. He (Qinghai/CN), G. F. Gao (Beijing/CN), D. Liu (Wuhan, Beijing/CN)

P 22 Beneficial effects of melatonin treatment in Influenza A infection and secondary infection by Streptococcus pneumoniaeJ. Del Sarto (Münster/DE; Belo Horizonte/BR), E. Mathias, L. Tavares, L. AlcantaraA. Machado (Belo Horizonte/BR), S. Ludwig (Münster/DE), M. Teixeira (Belo Horizonte/BR)

P 23 CD8+ T-cells Responding to the Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Delivered by Vaccinia Virus MVA in MiceS. Veit, S. Jany, R. Fux, G. Sutter, A. Volz (Munich/DE)

P 24 Neutralization mechanism of human MAbs against Rift Valley fever virusQ. Wang (Beijing/CN; Texas, TX/US; Shenzhen/CN), T. Ma (Hefei, Beijing/CN), Y. WuZ. Chen, H. Zeng, Z. Tong, F. Gao, J. Qi, Z. Zhao, Y. Chai (Beijing/CN)H. Yang (Hefei, Beijing/CN), G. Wong (Québec/CA), Y. Bi, L. Wu, R. Shi, M. Yang, J. SongH. Jiang (Beijing/CN), Z. An (Texas, TX/US), J. Wang (Beijing/CN), T. D. Yilma (Davis, CA/US) Y. Shi (Beijing, Shenzhen/CN), W. J. Liu, M. Liang, C. Qin (Beijing/CN)G. F. Gao (Hangzhou, Beijing, Shenzhen/CN), J. Yan (Beijing, Hefei, Shenzhen, Hangzhou/CN)

P 356 Characterization of the multi-functional NAKC binding site of HIV-1 NefS. Ananth, K. Morath, B. Trautz, B. Stolp, O. T. Fackler (Heidelberg/DE)

Antiviral Therapy and ResistanceP 25 Diversity mutation recombination and evolution of tomato leaf curl geminiviruses disease complex in Pakistan and its control strategies using RNAiM. Shafiq (Lahore/PK)

P 26 Influenza vRNP export block via Raf/MEK/ERK-pathway inhibition as an alternative anti-viral approachA. Schreiber, L. Boff, T. Krischuns, D. Anhlan, S. Ludwig (Münster/DE)

P 27 Inhibitors of BRD4 suppress HPV16 E6 expression and enhance chemoresponse againstCisplatin – A potential new target in cervical cancer therapy? O. Rataj, J. Haedicke-Jarboui, F. Stubenrauch, T. Iftner (Tübingen/DE)

P 28 Differential efficacy of novel antiviral substances in three-dimensional and monolayer cell cultureM. Neumann, R. Koban (Berlin/DE), P. Nelson (Marburg/DE), H. Ellerbrok (Berlin/DE)

44

POSTER SESSION 1

P 29 Designing and cytotoxicity evaluation of siRNAs against MERS-CoV in cell cultureS. S. Sohrab, S. A. El-Kafrawy, Z. Mirza, E. I. Azhar (Jeddah/SA)

P 30 The role of interferon α subtypes in control of Hepatitis D Virus infectionS. Westhaus, J. C. M. Anspach, S. Sichelschmidt, L. Timmer, K. Sutter, U. DittmerS. Ciesek (Essen/DE)

P 31 Development of Anti-Influenza Drugs Targeting the Viral HemagglutininM. Stadtmüller, S. Liese (Berlin/DE), K. Sellrie (Potsdam/DE), S. Bhatia, K. LudwigR. Netz (Berlin/DE), P. Seeberger (Potsdam/DE), A. Herrmann, R. Haag, T. Wolff (Berlin/DE)

P 32 Endosomal cholesterol imbalance is embedded in the IFN-induced host cell defense against incoming IAV and a druggable antiviral targetS. Schloer, J. Goretzko, A. Kühnl, L. Brunotte, S. Ludwig, U. Rescher (Münster/DE)

P 33 Monitoring antiviral drug susceptibility of influenza virusesS. Duwe, M. Wedde, R. Dürrwald (Berlin/DE)

P 34 Virus-specific cyclin-dependent kinase activity as a targeting strategy for cytomegalovirus-directed small moleculesM. Marschall, M. Steingruber, E. Socher, E. Sonntag, L. Keller, C. Wangen, C. HuttererJ. Milbradt, M. Thomas (Erlangen/DE), Y. Couté (Grenoble/FR), J. EickhoffB. Klebl (Dortmund/DE), S. B. Tsogoeva, H. Sticht, F. Hahn (Erlangen/DE)

P 36 New DSTP derivatives prevent entry of HCMVR. Adfeldt (Berlin/DE), M. Schmidtke (Jena/DE), V. Makarov (Moscow/RU)E. Bogner (Berlin/DE)

P 37 Herpes Virus Entry Mediator (HVEM) or CD270 regulates virus-specific CD8+ T-cells during acute retroviral infectionP. David, T. Werner, S. Schimmer (Essen/DE), J. I. Rodríguez Barbosa (León/ES), U. Dittmer G. Zelinskyy (Essen/DE)

P 38 The antiretroviral effects of LNA mixmers targeting HIV-1 sequences involved in viral RNA expressionF. Hillebrand, P. N. Ostermann, L. Müller, D. Degrandi (Düsseldorf/DE)M. Widera (Essen/DE), S. Erkelenz (Cologne/DE), K. Pfeffer, H. Schaal (Düsseldorf/DE)

P 39 Silvestrol inhibits Chikungunya virus replicationT. Scholz, L. Henß (Langen/DE), A. Grünweller (Marburg/DE), B. Schnierle (Langen/DE)

45

POSTER SESSION 1

46

POSTER SESSION 1

P 40 Decreased CD8 T-cell function induced by integrase inhibitorsE. Richter, M. Korencak, L. Bornemann, M. Schuster, M. Gunzer, S. Esser (Essen/DE)H. Streeck (Essen/DE; Rockville, MD/US)

P 41 T-cell based HLA-independent soluble immunotherapy against Cytomegalovirus infectionsN. Teufert (Erlangen/DE), C. Brey, J. Proff, B. Salzer (Vienna/AT), J. Brozy, M. MünzJ. Pendzialek (Munich/DE), W. Holter, M. Lehner (Vienna/AT), A. Ensser (Erlangen/DE)

P 42 Anti-viral activity of vitamin D3 and its metabolites against HBV, MV and AdV and its physiological concentrations in liver tissueK. Singethan (Brandenburg a. d. H., Munich/DE), W. Dammermann (Brandenburg a. d. H./DE)M. Feuerherd, M. Kächele (Munich/DE), C. Kühne, J. Schulze zur Wiesch (Hamburg/DE)U. Protzer (Munich/DE), S. Lüth (Brandenburg a. d. H./DE)

P 43 A transient early HBV DNA increase during PEG-IFNa therapy of hepatitis D is associatedwith subsequent HDV RNA response and HBsAg lossO. Anastasiou (Essen/DE), C. Yurdaydin (Ankara/TR), S. Hardtke (Hanover/DE)F. Alexandru Caruntu (Bucharest/RO), M. G. Curescu (Timisoara/RO)K. Yalcin (Diyarbakir/TR), U. S. Akarca (Izmir/TR), S. Gürel (Bursa/TR)S. Zeuzem (Frankfurt a. M./DE), A. Erhardt (Düsseldorf/DE), S. Lüth (Hamburg/DE)G. V. Papatheodoridis (Athen/GR), M. Radu (Bucharest/RO), M. P. MannsM. Cornberg (Hanover/DE), H. Wedemeyer (Hanover, Essen/DE)

P 44 Elucidating the relationship between molecular structure and antiviral activity of cationic amphiphilic drugsA.-P. Gunesch, F. J. Zapatero-Belinchon, M. P. Manns (Hanover, Braunschweig/DE) E. Steinmann (Bochum, Hanover, Braunschweig/DE)M. Brönstrup (Hanover, Braunschweig/DE), G. Schneider (Zurich/CH)T. von Hahn (Hanover, Braunschweig/DE)

P 45 Comparative analysis of the antiviral properties of Mediterranean plants – hints and clues in traditional herbal medicineC. Canavan (Dublin/IE), L. Tomas (Elche/ES), S. PhilippotS. Fontanay (Nancy, Vandoeuvre les Nancy/FR), J. Martínez (Madrid/ES)M. Varbanov (Nancy/FR)

P 46 Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce Ebola Virus Infection In VitroA. Sadewasser (Planegg, Martinsried/DE), E. Dietzel (Marburg/DE)S. Michel (Planegg, Martinsried/DE), M. Klüver (Marburg/DE), M. Helfer, T. ThelemannR. Klar (Planegg, Martinsried/DE), M. Eickmann, S. Becker (Marburg/DE)F. Jaschinski (Planegg, Martinsried/DE)

47

POSTER SESSION 1

P 47 Identification of endogenous antiviral peptides from body-derived peptide librariesC. Conzelmann, A. Röcker, F. Krüger, R. Groß, L. Steppe, N. Preising, L. Ständker, K. SparrerJ. Münch (Ulm/DE)

P 48 Antiviral potential of IFNα subtypes against influenza infection in a human lung explantmodelA. da Rocha Matos (Münster/DE; Rio de Janeiro/BR), K. Wunderlich, M. SedersM. de Witt (Münster/DE), R. Wiewrodt, K. Wiebe, P. Barth (Münster/DE), A. HockeS. Hippenstiel, K. Zscheppang (Berlin/DE), U. Dittmer, K. Sutter (Essen/DE)K. Schughart (Braunschweig/DE), S. Ludwig, L. Brunotte (Münster/DE)

P 49 Identification of small chemical compounds blocking tegumentation and assembly of Herpes Simplex VirusJ. C. Villalvazo Guerrero, A. Buch, D. Otoo, A. Pohlmann, G. Beauclair, J. Rückert, T. SchulzB. Sodeik (Hanover/DE)

P 50 The Flavonoid Houttuynoid B prevents cell entry of Zika VirusM. Basic, C. Sabino, F. Elgner (Langen/DE), H.-G. Schmalz (Cologne/DE)E. Hildt (Langen, Braunschweig/DE)

P 51 The HIV2EU project: current strategies and tools for the care of HIV-2 infective/positiveindividuals living in EuropeD. Berzow (Hamburg/DE), S. Matheron (Paris/FR), R. Kaiser (Cologne/DE)M. Obermeier (Berlin/DE), L. Guertler, J. Eberle (Munich/DE), D. DescampsC. Charpentier (Paris/FR), M. Döring (Saarbrücken/DE), J. Ruelle (Brussels/BE)N. Taylor (Salzburg/AT), S. Sierra (Cologne/DE), M. Stürmer (Frankfurt/DE)B. Jensen (Düsseldorf/DE), J. Rockstroh (Bonn/DE), R. Camacho (Leuven/BE)

P 52 Inhibitors of clinically relevant human polyomavirus infectionsE. Kraus (Hamburg, Borstel, Lübeck, Riems/DE), C. Schmidt (Hamburg/DE)J. Rückert (Hanover/DE), T. Schulz (Hanover, Braunschweig/DE), N. FischerA. Grundhoff (Hamburg, Borstel, Lübeck, Riems/DE)

P 53 Combination of inhibitors targeting prefusion F and G glycoproteins of respiratory syncytial virusL. Issmail, C. Möser, C. Jäger, M. Kleinschmidt, D. Ramsbeck, D. Smith, M. BuchholzT. Grunwald (Leipzig/DE)

P 55 CRISPR/Cas 9-mediated inhibition of African swine fever virus replication in cell cultureT. Kabuuka, A. Hübner (Greifswald – Isle of Riems/DE), B. Petersen (Neustadt/DE)K. Pannhorst, J. Carlson, G. Keil, T. C. Mettenleiter, W. Fuchs (Greifswald – Isle of Riems/DE)

P 56 Long-acting HIV-1 fusion inhibitory peptide and its resistance mechanismC. Wang, S. Cheng, Y. Zhang, M. Li, Y. Ding, H. Cheng, W. Liu, H. Xing, H. Liang, D. LiY. Shao (Beijing/CN), S. Jiang (Shanghai/CN), X. Li, L. Ma (Beijing/CN)

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P 57 Elucidation of the mechanism of Anti-Herpes Action of two novel Semisynthetic Cardenolide DerivativesL. Boff (Münster/DE; Florianópolis/BR), N. F. Z. Schneider, C. M. O. Simões (Florianópolis/BR)

P 58 A retrospective analysis of the EuResist data set assessing if NRTI resistance impairs INSTI based treatment with NRTI backboneU. Koppe (Berlin/DE), M. Böhm (Cologne/DE), L. Jovanovic (Belgrade/RS)T. B. Tufa (Assela/ET), J. Büch, T. Lengauer (Saarbrücken/DE), M. Zazzi, A. De Luca (Siena/IT) A. Sönnerborg (Stockholm/SE), F. Incardona, A. Bezencheck (Rome/IT)R. Kaiser (Cologne/DE), M. Doering (Saarbrücken/DE), S. Lennartz (Cologne/DE)M. Obermeier (Berlin/DE)

P 59 A novel neutralizing epitope on glycoprotein H of HCMVM. Thomas, B. Kropff, T. H. Winkler, H. Sticht (Erlangen/DE), W. J. Britt (Birmingham, AL/US) M. Mach, N. Reuter (Erlangen/DE)

P 60 A retrospective analysis of the EuResist data set assessing dual therapy success in a real-life contextO. Elvstam (Lund/SE), M. Böhm (Cologne/DE), D. Schmidt (Berlin/DE), J. Mlakar (Ljubljana/SI)E. Moench (Cologne/DE), C. Prifert (Würzburg/DE), T. Gehring (Bonn/DE)S. Popping (Rotterdam/NL), E. Moseholm Larsen (Copenhagen/DK), K. Bisaso (Kampala/UG)J. Büch, T. Lengauer (Saarbrücken/DE), M. Zazzi, A. De Luca (Siena/IT)A. Sönnerborg (Stockholm/SE), F. Incardona, A. Bezencheck (Rome/IT), S. LennartzR. Kaiser (Cologne/DE)

P 61 Quality control of HBV Drug Resistance Testing – Experiences from INSTAND EQA Schemes 2016–2018M. Kammel (Berlin, Düsseldorf/DE), A. Zimmermann, V. Lindig, W. Güthoff (Berlin/DE)C. Schüttler, H. Slanina, F. Lehmann, W. Gerlich, J. Ziebuhr, D. Glebe (Giessen/DE)H.-P. Grunert (Berlin/DE), H. Zeichhardt (Berlin, Düsseldorf/DE)

P 62 Analysis of determinants controlling antiviral activity of defective interfering influenza Avirus RNAsP. Arora, S. Gärtner, N. Bdeir (Göttingen/DE), M. Schwemmle (Freiburg/DE)U. Reichl (Magdeburg/DE), M. Winkler, S. Pöhlmann (Göttingen/DE)

P 63 Effectiveness of off-label used antiviral substancesP. Langsch, K. Wifling, J. Bodem (Würzburg/DE)

P 64 Fragment-based discovery of a qualified hit targeting the Latency-associated Nuclear Antigen of the oncogenic Kaposi’s Sarcoma-associated Herpesvirus/Human Herpesvirus 8P. Kirsch (Saarbrücken, Hanover, Braunschweig/DE), V. JakobK. Oberhausen (Saarbrücken/DE), S. C. Stein (Hanover, Braunschweig, Saarbrücken/DE)I. Cucarro (Saarbrücken/DE), T. F. Schulz M. Empting (Saarbrücken, Hanover, Braunschweig/DE)

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P 65 Hyperimmunoglobulin therapy during primary HCMV infection in pregnancy: definitionof inclusion criteriaK. Hamprecht, M. Schampera (Tübingen/DE), M. Enders (Stuttgart/DE)K.-O. Kagan (Tübingen/DE)

P 66 Structure-based Design of Broad-Spectrum Antivirals Targeting Coronaviruses and EnterovirusesL. Zhang (Lübeck/DE), D. Lin (Shanghai/CN; Lübeck/DE), Q. Ma, Y. Kusov (Lübeck/DE)H. Liu (Shanghai/CN), A. von Brunn (Munich/DE), P. Leyssen, K. Lanko, J. Neyts (Leuven/BE)A. de Wilde, E. J. Snijder (Leiden/NL), R. Hilgenfeld (Shanghai/CN; Lübeck/DE)

P 67 A system for production of defective interfering particles in the absence of infectious influenza A virusN. Bdeir, P. Arora, S. Gartner, M. Hoffmann (Göttingen/DE), U. Reichl (Magdeburg/DE)S. Pöhlmann, M. Winkler (Göttingen/DE)

P 68 Cold atmospheric plasma as antiviral therapy – effect on human herpes simplex virus type 1O. Bunz, K. Mese (Witten/DE), C. Funk, S. Bailer (Stuttgart/DE), A. PiwowarczykA. Ehrhardt (Witten/DE)

P 69 Cytomegalovirus-based HBsAg vaccine induces robust T-cell responses and results in viral clearance in HBV persistent miceH. Huang (Essen/DE; Wuhan/CN), T. Mirko, J. Liu (Essen/DE), D. Yang (Wuhan/CN; Essen/DE)M. Rückborn (Essen/DE)

P 70 Evaluation of susceptibility of HIV-1 CRF01_AE variants to neutralization by a panel of broadly neutralizing antibodiesR. Yang (Wuhan/CN), H. Wang (Wuhan, Beijing/CN), T. Yuan (Wuhan/CN)T. Li (Wuhan, Beijing/CN), Y. Li (Wuhan/CN), F. Qian, C. Zhu (Suzhou/CN)S. Liang (Nanning/CN), D. Hoffmann, U. Dittmer (Essen/DE), B. Sun, R. Yang (Wuhan/CN)

P 71 Selection of human cytomegalovirus mutants with resistance against the entry inhibitorPDGFRα-FcR. Engels (Ulm, Munich/DE), D. Stöhr, K. Österwinter, K. Laib Sampaio, C. Sinzger (Ulm/DE)

P 72 Prevalence of Active Hepatitis E Virus Infection and Efficacy of Ribavirin Treatment in Renal Allograft RecipientsJ. Friebus-Kardash, U. Eisenberger, J. Ackermann, A. Kribben, O. Witzke (Essen/DE)J. Wenzel (Regensburg/DE), H. Rohn, M. Fiedler (Essen/DE)

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Clinical VirologyP 73 Flu Pathogenesis Proteolytic Theory And Its Role In The Improvement of Flu’s TreatmentV. Divocha (Rubezhoe/UA)

P 74 Epstein-Barr-Virus (EBV) genome analyses by next-generation sequencing directly fromclinical specimens sampled from children with infectious mononucleosis (DZIF IMMUC study)A. Dhingra, Z.-L. Deng, C. Vogt (Hanover, Braunschweig/DE), K. Gerrer (Munich/DE)R. Williams (London/GB), M. Bodenhausen (Munich/DE), J. Breuer (London/GB)A. C. McHardy, T. F. Schulz (Hanover, Braunschweig/DE), U. Behrends (Munich/DE)T. Ganzenmueller (Hanover, Braunschweig, Tübingen/DE)

P 75 Early dissemination of recombinant human respiratory syncytial virus strains in cotton ratsL. Rijsbergen (Rotterdam/NL), L. Rennick (Boston, MA/US), S. NambulliP. Duprex (Pittsburgh, PA/US), R. de Swart, R. de Vries (Rotterdam/NL)

P 76 Inhibition of tubulin-dependent apical mislocalisation of Na+,K+-ATPase in influenza virus-infected cells, improving vectorial water transport and pulmonary edema clearanceI. Kuznetsova, C. Peteranderl (Giessen/DE), J. Schulze (Berlin/DE)B. Selvakumar (Giessen/DE), T. Wolff (Berlin/DE), S. Herold, S. Pleschka (Giessen/DE)

P 77 Invasion of HSV-1 into skin of atopic dermatitis patients: Do epidermal barrier defects facilitate viral entry?M. Möckel, L. Wirtz (Cologne/DE), L. Maintz, T. Bieber (Bonn/DE)D. Knebel-Mörsdorf (Cologne/DE)

P 78 Investigation of Torque Teno Virus replication as a potential factor for invasive Adenovirus infections in pediatric allogeneic HSCT-recipientsK. Kosulin, S. Kernbichler, H. Pichler, A. Lawitschka, R. Geyeregger, V. WittT. Lion (Vienna/AT)

P 79 Molecular identification and confirmation of ovine gammaherpesvirus 2 inducedmalignant catarrhal fever in Saxony dairy FarmA. Muluneh (Dresden/DE), T. Seifert (Pfaffroda/DE), A. Petereit (Dresden/DE)

P 80 Investigation of a porcine teschovirus infection in grower pigs with neurological signs:a longitudinal studyM. Walther, N. Grützner (Halle a. d. S./DE), S. Reiche, K. Goller (Greifswald – Isle of Riems/DE)C. Bredtmann, C. Gurtner (Bern/CH), K. Albrecht (Stendal/DE), P. ScheerH. Nathues (Bern/CH)

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P 81 Human herpesvirus type 7 as a predisposing factor for CMV reactivation in group of patients subjected to allogeneic hematopoietic stem cells transplantation – a single centre studyM. Przybylski, A. Zuk-Wasek, P. Boczek, J. Bilinski, A. Waszczuk-Gajda, M. Krol, J. Rogowska A. Tomaszewska, G. W. Basak, M. Wroblewska, T. Dzieciatkowski (Warsaw/PL)

P 82 Presence of cytomegaloviral DNA in sera samples of allogeneic hematopoietic stem cells recipients in Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw in years 2013–2017P. Boczek, M. Przybylski, M. Krol, J. Rogowska, A. Zuk-Wasek, J. Bilinski, A. Waszczuk-Gajda A. Tomaszewska, G. W. Basak, M. Wroblewska, T. Dzieciatkowski (Warsaw/PL)

P 83 BKPyV genotyping as a simple tool for risk assessment for PyVAN and transplant outcome after renal transplantationJ. Korth, O. E. Anastasiou (Essen/DE), J. H. Bräsen (Hanover/DE), A. Brinkhoff (Essen/DE)U. Lehmann (Hanover/DE), A. Kribben, U. Dittmer, J. Verheyen, B. Wilde, S. CiesekO. Witzke, M. Widera (Essen/DE)

P 84 Active focal epithelial hyperplasia in a bonobo more than 30 years after papillomavirus infectionM. Hoffmann (Göttingen/DE), E. Schütze, A. Bernhard (Leipzig/DE), L. SchlaphoffA. Kaul (Göttingen/DE), S. Schöniger (Leipzig/DE), S. Pöhlmann (Göttingen/DE)

P 85 Quantifying Cytomegalovirus-specific T-cell Responses Prior to Hospital Discharge Allows Risk Stratification for Late Viral Reactivation after Allogenic Hematopoietic Cell TransplantationR. Wagner, R. Kiener (Regensburg/DE), T. Stevens-Ayers, H. Xie, M. Boeckh (Seattle, WA/US)

P 86 HCV treatment optimization through phenotypic resistance testingR. Costa, T. Bartsch (Essen/DE), J. Dietz (Frankfurt a. M./DE), S. Ross (Essen/DE), M. Manns T. von Hahn (Hanover/DE), C. Sarrazin (Frankfurt a. M./DE), S. Ciesek (Essen/DE)

P 87 A Case of Long-term Herpes Simplex Virus DNAemia in a 1-Year-Old ChildS. Aldabbagh, K. Gries, I. Hainmann, A. Müller, S. Buderus, B. Marx (Bonn/DE), D. HuzlyC. Speckmann (Freiburg/DE), R. Kaiser (Cologne/DE), A. Eis-Hübinger (Bonn/DE)

P 88 Whole genome sequencing of influenza A(H1N1)pdm09 viruses isolated from patients with mild or severe outcomeM. Wedde, B. Schweiger, T. Wolff, R. Dürrwald (Berlin/DE)

P 89 Piscine Orthoreovirus 3 is not the causative pathogen of proliferative darkening syndrome of brown trout (Salmo trutta fario)R. Fux, D. Arndt, M. Langenmayer (Munich/DE), J. Schwaiger, H. Ferling (Wielenbach/DE)N. Fischer, D. Indenbirken, A. Grundhoff (Hamburg/DE), L. Dölken (Würzburg/DE)M. Adamek, D. Steinhagen (Hanover/DE), G. Sutter (Munich/DE)

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P 90 First reported case of fetal microcephaly associated with Zika virus infection in a German traveler returning from ThailandJ. Zimmermann, R. Egensperger, F. Weiss, A. Osterman, F. Wehweck, S. Böhm, O. T. Keppler S. Hutter, R. Kästner, J. Eberle (Munich/DE)

Diagnostic Methods and ToolsP 91 The new SOLANA molecular diagnostic platform: Results of an in-house testing on samples for external quality controlL. Schüer, A. Birk, J. Becker, A. Breß, J. Kehle, A. Kleusberg (Kornwestheim/DE)

P 92 Generation and characterization of yellow fever antigens for diagnostic immunoassaysL. Roßbacher, I. Medits, J. Aberle, F. X. Heinz, K. Stiasny (Vienna/AT)

P 93 Congenital CMV infection in newborns: impact of pre-analytic factors for laboratory diagnosisN. Kohmer (Frankfurt a. M./DE), A. Nagel (Erlangen/DE), A. Berger (Frankfurt a. M./DE)M. Enders (Stuttgart/DE), K. Hamprecht (Tübingen/DE), K. Korn (Erlangen/DE)M. Kortenbusch (Frankfurt a. M./DE), K. Überla (Erlangen/DE)H. F. Rabenau (Frankfurt a. M./DE)

P 94 A new multiplex real time RT-PCR for detection and differentiation of avian bornavirusesB. Sigrist, S. Albini, N. Wolfrum (Zurich/CH)

P 95 Establishment of a BK-Polyomavirus in vitro system for drug screeningN. Frericks, S. Westhaus, M. Widera, M. Trilling, S. Ciesek (Essen/DE)

P 96 Whole genome sequencing of avian rotavirus strains using NGSC. Patzina-Mehling, A. Falkenhagen, J. Grützke, S. Tausch, R. Johne (Berlin/DE)

P 97 The impact of the RNA extraction method (manual vs automated) on HDV viral load quantificationO. Anastasiou (Essen/DE), B. Bremer (Hanover/DE), S. CiesekH. Wedemeyer (Essen, Hanover/DE)

P 98 Establishment of anti-Hepatitis C virus IgG Avidity test for Dried Serum/Plasma SpotsA. Eshetu, M. an der Heiden, D. Schmidt, K. Meixenberger (Berlin/DE), S. Ross (Essen/DE) M. Obermeier, R. Ehret, C.-T. Bock, B. Bartmeyer, V. Bremer, N. BannertA. Hauser (Berlin/DE)

P 99 Zika virus envelope-specific antibodies: production and characterizationS. Akhras, F. Elgner, T. Holzhauser (Langen/DE), E. Hildt (Langen, Braunschweig/DE)

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P 100 Synthesis and Characterisation of chimeric Marburg virus GP-specific antibodiesC. Spiegelberg, S. Becker, O. Dolnik (Marburg/DE)

P 101 Validation of a highly sensitive IFN-γ ELISpot assay to monitor CMV-specific cell-mediated immunity in immunocompromised patientsL. Deml, S. Barabas, T. Spindler, R. Kiener, T. Lugner (Regensburg/DE), D. SteublL. Renders (Munich/DE), D. Chittka, M. Banas (Regensburg/DE), T. Wekerle (Vienna/AT)M. Koch (Hamburg-Eppendorf, Mainz/DE), O. Witzke (Essen/DE), A. Muehlfeld (Aachen/DE) C. Sommerer (Heidelberg/DE), A. Habicht (Munich/DE), C. Hugo (Dresden/DE)T. Huenig (Würzburg/DE), M. Lindemann (Essen/DE), J. Batzilla, M. Schemmerer, J. Koestler H. Bendfeldt, T. Schmidt, A. Rascle, C. Boeger (Regensburg/DE), B. KruegerB. Kraemer (Mannheim/DE), B. Banas, R. Wagner (Regensburg/DE)

P 102 Persistent virus infection in mosquito derived cellsK. Franzke (Greifswald – Isle of Riems/DE), M. Leggewie (Hamburg/DE)S. Vattipally (Glasgow/GB), S. Jansen, A. Heitmann (Hamburg/DE), S. Welch, B. BrennanR. Elliott (Glasgow/GB), E. Tannich (Hamburg/DE), S. Becker (Hanover/DE)E. Schnettler (Hamburg/DE)

P 103 yellow fever virus diagnosis kit developmentY. Li, G. F. Gao (Beijing/CN)

P 104 Cost-efficient Hepatitis E genome sequencing and quasispecies determination by Capture- Probe Targeting and Next Generation Sequencing (NGS)S. Gundlach (partner site Hamburg, Borstel, Lübeck, Riems/DE), A. LessD. Indenbirken (Hamburg/DE), S. Pischke, C. Dahlke , M. Addo, M. LütgehetmannJ. Huang (Hamburg/DE), N. Fischer (Hamburg, Borstel, Lübeck, Riems/DE)

P 105 Reliable detection of Lassa virus using combination of two real-time RT-PCR assays targeting S and L segmentsL. Oestereich (Hamburg/DE), S. Ölschläger (Uetersen/DE), L. HechtM. Zaruba (Hamburg/DE), K. Patel (Atlanta, GA/US), S. Duraffour, M. Pahlmann, J. MüllerE. Pallasch, A. Thielebein, J. Hinzmann (Hamburg/DE), Y. Ighodalo, D. Adomeh, I. OdiaC. Aire, E. Tobin, D. Asogun, E. Ogbaini-Emovon (Irrua/NG), S. Günther (Hamburg/DE)

P 106 A targeted proteomics assay for the detection of potential bioterror virusesM. Grossegesse, J. Doellinger, A. Nitsche (Berlin/DE)

P 107 Diagnostic assay development for mouse parvovirus (MPV) and minute virus of mice (MVM) based on recombinant expressed proteins VP2 and NS1M. Harzer, A. Rückner, K. Heenemann, M. Sieg, F. Fingas, T. W. Vahlenkamp (Leipzig/DE)

P 108 Comparison of three different readouts for determination of neutralization titers against human cytomegalovirus in serum and plasma samplesJ. Falk, C. Sinzger, M. Winkelmann (Ulm/DE)

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P 109 Next generation sequencing of Hepatitis B virus with the Vela Sentosa HBV genotypingand resistance assayM. Obermeier, A. Moritz, M. Schütze, S. Breuer, R. Ehret (Berlin/DE)

P 110 Seroprevalence of viral infections in a colony of captive macaquesA. Kaul, U. Schönmann, S. Pöhlmann (Göttingen/DE)

P 111 Tracking Modified Vaccinia virus Ankara in the chicken embryo: In vivo tropism and pathogenesis of egg infectionsA. Volz, M. Langenmayer, A. Luelf-Averhoff, S. Adam-Neumaier, G. Sutter (Munich/DE)

P 112 Metabolic labeling and GRAND-SLAM identify virus-induced changes on isoform usageC. Jürges, L. Dölken, F. Erhard (Würzburg/DE)

P 113 The value of Torque Teno Virus (TTV) as a marker for the degree of immunosuppression in adults patients after hematopoetic stem cell transplantation (HSCT)O. Adams, J. Schmitz, G. Kobbe (Düsseldorf/DE)

P 114 HPV oncogene mRNA testing for the detection of anal dysplasia in HIV-positive men who have sex with menS. Silling (Cologne/DE), A. Kreuter (Oberhausen/DE), J. Swoboda (Bonn/DE)F. Oellig (Mülheim a. d. R./DE), N. H. Brockmeyer, A. Potthoff (Bochum/DE)M. Hellmich, U. Wieland (Cologne/DE)

P 115 Comparison of a novel monotest assay for detection of anti-Hepatitis-E-Virus-IgG and -IgM with routine immunoblot and ELISA assaysA. Osterman, K. Dichtl, M. Köppel, S. Böhm (Munich/DE)

Viral Genome ReplicationP 116 Biochemical characterization of the Lassa virus L proteinD. Vogel, M. Rosenthal, N. Gogrefe, S. Reindl, S. Günther (Hamburg/DE)

P 117 Revising arenavirus persistence: Visualization and characterization of formerly virus-infected but surviving hepatocytesP. Reuther, K. Martin (Basel/CH), D. Merkler (Geneva/CH), D. Pinschewer (Basel/CH)

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P 118 Identification of the direct interactor of the papillomavirus E8^E2 protein in the NCOR/SMRT repressor complexT. Mönch, E. Straub, M. Schindler, T. Iftner, F. Stubenrauch (Tübingen/DE)

P 119 Identification of NS2 determinants stimulating intrinsic NS2 protease activity- molecular insights into the HCV NS2-NS3 autoprotease mechanismT. Walther, O. Isken, L. Wong, N. Tautz (Lübeck/DE)

P 120 Early, but not late, promoters of Acanthocystis turfacea Chlorella Virus-1 (ATCV-1) areactive in host cellsA. Pfitzner, K. Lindner, B. Wahl (Stuttgart/DE)

P 121 Preservation of Coronavirus genome integrityN. Ebert (Bern/CH)

P 122 Growth defects in UL89 mutants of human cytomegalovirus TB40/E BAC 4J. Theiß, B. Vetter, L. Wiebusch, E. Bogner (Berlin/DE)

P 123 Identification and characterization of a human coronavirus 229E nonstructural protein8-associated RNA 3’-terminal adenylyltransferase activityJ. Tvarogová, R. Madhugiri, G. Bylapudi (Giessen/DE), L. Ferguson (Belfast/GB), K. IvanovN. Karl, J. Ziebuhr (Giessen/DE)

P 124 The transcriptional and translational landscape of the Marek’s disease virus (MDV) genome in in vitro infected primary chicken B cellsL. D. Bertzbach (Berlin/DE), F. Pfaff, V. I. Pauker (Greifswald – Isle of Riems/DE)S. Härtle (Munich/DE), A. Karger (Greifswald – Isle of Riems/DE), B. B. Kaufer (Berlin/DE)

P 125 Effect of Apobec3c on HIV-1A. A. Jaguva Vasudevan, K. Balakrishnan, Z. Zhang, D. Häussinger, C. Münk (Düsseldorf/DE)

P 126 “In silico prediction of evolutionary conserved RNA secondary structures in the MERS-CoV RNA genome”B. Alhatlani (Unayzah/SA)

P 127 Putting deletions on the map – Prevalence of structural variations in HBV quasispeciesM. Theissen (Essen/DE), T. Schwarz (Düsseldorf/DE), D. Habermann (Essen/DE), A. WalkerJ. Timm (Düsseldorf/DE), D. Hoffmann (Essen/DE)

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P 128 Impact of single and dual mTOR inhibitors on the BK-Polyomavirus non coding control regionJ. Korth, O. E. Anastasiou, J. Verheyen, J. Dickow, H. Sertznig, N. Frericks, B. BleekmannA. Kribben, A. Brinkhoff, B. Wilde, K. Sutter, U. Dittmer, S. Ciesek, O. WitzkeM. Widera (Essen/DE)

P 129 SilentMutations (SIM): a tool for analyzing long-range RNA-RNA interactions in viral genomes and structured RNAsD. Desirò, M. Hölzer, B. Ibrahim, M. Marz (Jena/DE)

P 130 Understanding the role of Staufen proteins in APOBEC3G stress granule mediated regulation of HIV-1 propagationK. Balakrishnan (Düsseldorf/DE; Hyderabad, Telangana/IN), D. HäussingerC. Münk (Düsseldorf/DE), S. Banerjee (Hyderabad, Telangana/IN)

P 131 Mathematical Modeling Helps to Unravel the Mode of Action of Direct-Acting Antivirals against Hepatitis C VirusC. Dächert (Heidelberg/DE), D. Schweinoch (Greifswald – Isle of Riems/DE)A. Pandey (Basel/CH), L. Kaderali (Greifswald – Isle of Riems/DE), M. Binder (Heidelberg/DE)

P 132 Expression of HIV Gag from a subgenomic reporter gene is limited by an RNA motif located in the 5’ part of the sequenceT. Schuster, B. Asbach, R. Wagner (Regensburg/DE)

P 133 Contribution of quasispecies diversity and de novo mutations to Morbillivirus adaptationM. Dörr, M. Herrmann, V. von Messling (Langen/DE)

P 134 Paramyxovirus mRNA polyadenylation: downstream effects on viral protein expressionB. Sawatsky, K. Brück, V. von Messling (Langen/DE)

P 135 Conserved RNA secondary structures and their role during discontinuous transcriptionin coronavirusesS. Krautwurst, K. Lamkiewicz (Jena/DE), R. Madhugiri (Giessen/DE)J. Ziebuhr (Giessen, Jena/DE), M. Hölzer, B. Ibrahim (Jena/DE)

P 136 VeGETA: whole viral genome multiple sequence alignments based on RNA secondary structuresK. Lamkiewicz, M. Kayser, E. Barth, M. Marz (Jena/DE)

P 137 HBV virions produced under nucleos(t)ide analogues treatment are not infectious dueto irreversible DNA chain terminationF. Lu (Beijing/CN)

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P 138 Productive replication of peste des petits ruminants virus Nigeria 75/1 vaccine strain in Vero cells correlates with inefficiency of maturation of the viral fusion proteinN. A. Osman (Khartoum-North/SD; Greifswald – Isle of Riems/DE), R. Portugal, K. GiesowG. Keil (Greifswald – Isle of Riems/DE)

P 139 First molecular clone of chronic bee paralysis virus (CBPV)K. Seitz, T. Rümenapf, N. Dinhopl, B. Lamp (Vienna/AT)

P 140 Amino acid variations at residue 101 within Rev present different effects on viral replication capacity between HIV-1 clade BC and clade BZ. Wang, X. Ji, Y. Hao, K. Hong, L. Ma, Y. Shao (Beijing/CN)

P 141 Regulation of RNA Polymerase II in Herpes Simplex Virus 1 InfectionA. Whisnant, L. Djakovic, C. Jürges, F. Künzig, F. Erhard, L. Dölken (Würzburg/DE)

P 142 Nanopore direct RNA sequencing reveals modification in full-length coronavirus genomesS. Krautwurst (Jena/DE), A. Viehweger (Jena, Leipzig/DE), M. Marz (Jena/DE)

P 143 Establishment of Chimpanzee Cytomegalovirus Bacterial Artificial Chromosome for the dissection of the pUL32 mediated cell cycle dependency in HCMVQ. V. Phan, C. Hagemeier, L. Wiebusch (Berlin/DE)

P 145 Analysis of the human cytomegalovirus TB40 transcriptome by Nanopore long-read sequencingJ. Ptok, M. Maywald, A. Dilthey, A. Zimmermann (Düsseldorf/DE)

P 146 The mouse cytomegalovirus-encoded M34 is not essential for viral replicationM. Eilbrecht, V. T. K. Le-Trilling, M. Trilling (Essen/DE)

P 147 Role of cellular phosphatase PP2A-dependent dephosphorylation of filoviral VP30s forviral transcription and replicationC. Rohde, I. von Creytz, T. Tharra, N. Mostajo-Berrospi (Marburg/DE), T. Kruse, E. P. T. HertzJ. Nilsson (Copenhagen/DK), S. Becker, N. Biedenkopf (Marburg/DE)

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Emerging Viruses and ZoonosesP 148 Genetic and antigenic diversification of currently circulating G1-like H9 avian influenzavirusesR. Parvin, K. E. Hassan, M. Beer, T. C. Harder (Greifswald – Isle of Riems/DE)

P 150 The Ovarian Tumor (OTU) domain of Crimean-Congo Hemorrhagic Fever virus (CCHFV) influences the polymerase RdRp activity, but does not counteract innate immunityS. Devignot (Giessen/DE), A. Mirazimi (Solna, Uppsala/SE), F. Weber (Giessen/DE)

P 151 Isolation of three novel Hepatitis E Virus strains stably replicating to high viral loads inan optimized cell culture systemM. Schemmerer (Regensburg/DE), R. Johne (Berlin/DE), M. Erl, W. JilgJ. Wenzel (Regensburg/DE)

P 152 Severe encephalitis caused by mammalian 1 orthobornavirusK. Korn, R. Coras, P. Steininger, T. Bobinger, D. Jungnickl, R. Stöhr, A. HilpertH. Lücking (Erlangen/DE), S. M. Herzog (Giessen/DE), S. Kürten, H. B. Huttner, A. Hartmann A. Ensser (Erlangen/DE)

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POSTER SESSION 1

Virus ELISA IIFTChikungunya

Dengue 1– 4

FSME

Gelbfi eber

Hanta*

Japanische-EnzephalitisKrim-Kongo-hämorrhagisches-FieberLa Crosse-Enzephalitis

Mayaro

MERS corona

Murray-Tal-Enzephalitis

Östliche Pferde-Enzephalitis

Rift-Tal-Fieber

Ross River

Sandfl iegen-Fieber

SARS corona

Sindbis

St.-Louis-Enzephalitis

Usutu

Venezolanische Pferde-Enzephalitis

West-Nil

Westliche Pferde-Enzephalitis

Zika

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Leishmania donovani

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Zika-Virus und anderen TropenkrankheitenZika-Virus und anderen Tropenkrankheiten

60

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P153 Novel Hepatitis E Virus Genotype 1 and 2 Variants Identified in an Outbreak in Nigeria,2017B. Wang, O. Akanbi, D. Harms (Berlin/DE), C. Ihekweazu (Abuja/NG)C.-T. Bock (Berlin, Tübingen/DE)

P 154 Susceptibility of tick-borne encephalitis virus and related flaviviruses to inactivation byheat, chemicals, low pH and UV light exposureL. Wiesner, I. Steffen (Hanover/DE)

P 155 Generation of Rotavirus Reassortants using a Plasmid-based Reverse Genetics SystemA. Falkenhagen, R. Johne (Berlin/DE)

P 156 Molecular cloning and characterization of the genes encoding the proteins of tick-borne encephalitis virusV. Breitkopf, I. Steffen (Hanover/DE)

P 157 News about the cowpox virus reservoir – Are host-species specific strains the key?S. Weber, K. Jeske, F. Pfaff, R. G. Ulrich, M. BeerD. Hoffmann (Greifswald – Isle of Riems/DE)

P 158 A MERS-coronavirus variant that emerged during the Korean outbreak was partially resistant against antibody-mediated neutralizationH. Kleine-Weber, M. T. Elzayat, M. Hoffmann, S. Pöhlmann (Göttingen/DE), L. WangB. S. Graham (Bethesda, MD/US), M. A. Müller, C. Drosten (Berlin/DE)

P 159 Small animal models for variegated squirrel bornavirus 1 (VSBV-1)K. Schlottau, M. Beer (Greifswald – Isle of Riems/DE), D. Nobach, C. Herden (Giessen/DE)D. Hoffmann (Greifswald – Isle of Riems/DE)

P 160 Vaccination of Rousettus aegyptiacus Friut Bats with Rift Valley Fever Vaccine Strain MP-12 Proves Competence of this Species as a Putative Reservoir HostM. Rissmann, A. Balkema-Buschmann, N. Kley, R. Ulrich, M. H. GroschupM. Eiden (Greifswald – Isle of Riems/DE)

P 161 Inhibition of GSK3 preferentially inhibits a Zika Virus strain from AsiaF. Elgner, D. Bender (Langen/DE), C. Lange, S. Zeuzem (Frankfurt a. M./DE)K.-H. Peiffer (Langen, Frankfurt/DE), E. Hildt (Langen, Braunschweig/DE)

P 162 The GTPase GBP1 is an antiviral host-factor against HEV and is dysregulated during thevirus’ life cycleM. Glitscher, K. Himmelsbach, A. Schollmeier, C. Kuge, M. Koenig, N. NouriG. Praefcke (Langen/DE), E. Hildt (Langen, Braunschweig/DE)

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P 163 Determination of hemorrhagic fever virus host factors through a co-infection model with hepatitis C virusR. Moeller (Hanover/DE), M. Flosbach (Munich/DE), W. Nicolay (Hanover/DE)H. Moreno (Lausanne/CH), T. Pietschmann (Hanover/DE), S. Kunz (Lausanne/CH)G. Gerold (Hanover/DE; Umeå/SE)

P 164 Evolutionary evidence for multi-host transmission of cetacean morbillivirusW. Jo, J. Kruppa, A. Habierski (Hanover/DE), M. van de Bildt (Rotterdam/NL)S. Mazzariol (Legnaro/IT), G. Di Guardo (Teramo/IT), U. Siebert (Büsum/DE)T. Kuiken (Rotterdam/NL), K. Jung, A. Osterhaus, M. Ludlow (Hanover/DE)

P 165 Polymorphism in the hemagglutinin proteolytic cleavage site of H9N2 affected proteolytic activation and cell-to-cell spread in cell culture and virus excretion in infected chickensC. Blaurock, D. Scheibner, M. Gischke, T. C. MettenleiterE. M. Abdelwhab (Greifswald – Isle of Riems/DE)

P 166 High virulence of a natural H4N2 avian influenza virus with a polybasic cleavage motif after mutation in the hemagglutinin, reassortment with highly pathogenic H5N1 virus or serial passages in eggsM. Gischke, R. Ulrich, F. Winter, O. I. Fatola, D. Scheibner, A. Salaheldin, J. VeitsT. C. Mettenleiter, E. Abdelwhab (Greifswald – Isle of Riems/DE)

P 167 Emerging Viruses and Zoonoses: Data from QCMD External Quality Assessment (EQA)Schemes for WNV and HEV in the Context of Blood Safety MeasuresO. Donoso Mantke (Berlin/DE), E. McCulloch (Glasgow/GB)J. Schmidt-Chanasit (Hamburg/DE), M. Niedrig (Berlin/DE), J. J. Wenzel (Regensburg/DE)M. Chudy (Langen/DE), B. Niesters (Groningen/NL)

P 168 Rescue and characterization of the divergent TBEV-Eu strain SallandT. Hoornweg, G.-J. Godeke (Bilthoven/NL)

P 169 Arenavirus persistence in Mastomys natalensis, the natural rodent reservoir of Lassa virusC. Hoffmann, E. Pallasch, S. Bockholt, D. M. Wozniak, J. Müller, L. OestereichS. Günther (Hamburg/DE)

P 170 Rapid adaptation of bat-derived H18N11 influenza A-like virus to non-bat host speciesK. Ciminski, W. Ran (Freiburg/DE), M. Gorka, A. Pohlmann, J. Schinköthe, R. UlrichD. Hoffmann (Greifswald – Isle of Riems/DE), A. García-Sastre (New York, NY/US)W. Ma (Manhattan, NY/US), T. Schountz (Fort Collins, CO/US)M. Beer (Greifswald – Isle of Riems/DE), M. Schwemmle (Freiburg/DE)

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P 171 Seroprevalence study of anti-Ebolavirus (EBOV) immunoglobulin G (IgG) at the index site of 2013-2016 West African EBOV outbreak – insight into early transmission and case fatality rateM. Carroll, Y. Hall (Salisbury/GB), J. Akoi Bore (Gueckedou/GN)B. Diallo (Gueckedou/GN; Kinshasa/CD), T. Tipton (Salisbury/GB), H. Bower, J. GlynnJ. Timothy (London/GB)

P 172 Inoculation of Seba”s short-tailed bats (Carollia perspicillata) with bat influenza A virusof subtype H18N11M. Gorka, R. Ulrich, J. Schinköthe (Greifswald – Isle of Riems/DE), K. Ciminski (Freiburg/DE)D. Hoffmann (Greifswald – Isle of Riems/DE), M. Schwemmle (Freiburg/DE)M. Beer (Greifswald – Isle of Riems/DE)

P 173 Egyptian poultry: A mixing bowl of different avian influenza virus sub- and pathotypesK. E. Hassan (Greifswald – Isle of Riems/DE), M. el Khady (Beni-Suef/EG)A. el-Sawah, R. Parvin, M. Beer (Beni-Suef/EG; Myminsingh/BD)

P 174 Mutations in conserved neuraminidase residues of avian influenza H5N1 virus naturally isolated from humans modulated sialidase activity and virulence in mice but not in chickensA. Salaheldin, U. Blohm, M. Gischke, D. Scheibner, D. Hoffmann, J. Veits, T. C. Mettenleiter E. M. Abdelwhab (Greifswald – Isle of Riems/DE)

P 175 Bovine hepacivirus field infections: serological response, course of infection, and host tropismC. Bächlein, A. L. Baron, D. Meyer, L. Gorriz-Martin, V. M. PfankucheW. Baumgärtner (Hanover/DE), S. Polywka, S. Peine, N. Fischer (Hamburg/DE), J. RehageP. Becher (Hanover/DE)

P 176 Identification and characterization of novel viruses in domestic animals and wildlifeS. T. Jesse, W. K. Jo, L. van Dyck, V. Pfankuche, C. Puff, I. I. Baumann, K. JungW. Baumgärtner, M. Ludlow, A. Osterhaus (Hanover/DE)

P 177 A novel pigeon-associated clade of rotavirus A (RVA) causes “young pigeon disease syndrome” (YPDS)D. Rubbenstroth (Greifswald – Isle of Riems, Freiburg/DE), C. Wylezich, R. UlrichA. Pohlmann (Greifswald – Isle of Riems/DE), E. Peus (Essen/DE)C. Schulze (Frankfurt a. d. O./DE), S. Rautenschlein, L. Mohr (Hanover/DE)

63

POSTER SESSION 2

P 178 Novel virus related to Kaposi”s sarcoma-associated herpesvirus from a monkey (Colobus guereza) suffering from primary effusion lymphomaA. Dhingra (Hanover, Braunschweig/DE)T. Ganzenmueller (Hanover, Braunschweig, Tübingen/DE), E. Hage (Hanover/DE)N. Suarez (Glasgow/GB), K. Mätz-Rensing (Göttingen/DE), D. Widmer (Dresden/DE)S. Pöhlmann (Dresden, Göttingen/DE), A. J. Davison (Glasgow/GB)T. F. Schulz (Hanover, Braunschweig/DE), A. Kaul (Göttingen/DE)

P 179 Robust hepatitis E virus infection in tissue culture by a replication enhancing mutationD. Todt (Bochum, Hanover/DE), M. Friesland, N. Moeller (Hanover/DE)D. Praditya (Bochum, Hanover/DE), L. Knegendorf (Hanover/DE)J. Steinmann (Essen, Nuremberg/DE), F. W. R. Vondran (Hanover/DE)P. Meuleman (Ghent/BE), P. Behrendt (Hanover/DE), E. Steinmann (Bochum, Hanover/DE)

P 180 A recombinant fosmid-based system for analysis of primate herpesvirusesE. Chukhno, A. Mehr, S. Gärtner, S. Pöhlmann, M. Winkler (Göttingen/DE)

P 181 Impact of internal protein-encoding segments from Eurasian H9N2-type avian influenza A virus (IAV) reassorted into co-circulating highly pathogenic H5N8-type IAV strainson viral replication and pathogenicity in mammalian systems in vitro and in vivoA. Mostafa (Giessen/DE; Dokki, Cairo/EG), E.-S. M. Abd El-Whab, C. MüllerT. C. Mettenleiter, S. Pleschka (Giessen/DE)

P 182 3D Imaging of Virus Infection in Solvent-Cleared OrgansL. Zaeck, M. Potratz, S. Finke (Greifswald – Isle of Riems/DE)

P 183 Temperature dependent transmission of Zika virus by mosquitoes from Central EuropeS. Jansen, A. Heitmann, R. Lühken, M. Leggewie (Hamburg/DE), B. Pluskota (Speyer/DE)N. Becker (Heidelberg, Speyer/DE), O. Vapalahti (Helsinki/FI), J. Schmidt-ChanasitE. Tannich (Hamburg/DE)

P 184 Semen Inhibits Zika Virus Infection of Cells and Tissues from the Anogenital RegionJ. Müller, M. Harms, F. Krüger, S. Joas, R. Groß, M. Hayn, N. Sandi-Monroy, A. DietzS. Lippold, J. von Einem, A. Schubert, B. Mayer (Ulm/DE), M. Cortese (Heidelberg/DE)K. Jang (San Francisco, CA//US), M. Deniz (Ulm/DE), F. Ebner (Ulm, Dachau/DE)R. Bartenschlager (Heidelberg/DE), J. Schmidt-Chanasit (Hamburg, Heidelberg/DE)N. Roan (San Francisco, CA/US), J. Münch (Ulm/DE)

P 185 Hantaviral N proteins play a role as pathogenicity factorS. Hägele (Chicago, IL/US), A. Müller (Heidelberg/DE), J. Reiser (Chicago, IL/US), M. ZeierE. Krautkrämer (Heidelberg/DE)

64

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P 186 Follow-up of survivors of Lassa Fever in Edo State, Nigeria: study of Lassa virus persistence and correlates of immunityA. Thielebein, J. Hinzmann, J. Müller (Hamburg/DE), D. Adomeh, Y. Ighodalo, T. OlokorR. Esumeh, R. Omiunu, A. Ekanem, N. Akpede, A. Taju (Irrua/NG)D. Ehichioya (Hamburg/DE; Irrua/NG), D. Asogun, E. Ogbaini-Emovon (Irrua/NG)M. Pahlmann, L. Oestereich, S. Duraffour, S. Günther (Hamburg/DE)

P 187 Recombinant Modified Vaccinia virus Ankara delivering the G antigen of Nipah virusG. Kalodimou, S. Veit, S. Jany, G. Sutter, A. Volz (Munich/DE)

P 188 Primary Synovial Fibroblasts as an ex vivo model for CHIKV infectionF. Pott (Hanover, Berlin/DE), R. Brown (Langen, Hanover/DE), T. Pietschmann (Hanover/DE) E. Neumann (Bad Nauheim/DE), C. Goffinet (Berlin, Hanover/DE)

P 189 Agua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New WorldK. Hermanns (Berlin/DE), M. Marklewitz (Bonn, Cologne, Berlin/DE)F. Zirkel (Bonn, Cologne/DE), C. Drosten, S. Junglen (Berlin, Bonn, Cologne/DE)

P 190 Clinical course of infection and cross-species transmission of equine parvovirusB. Tegtmeyer (Hanover/DE), V. Kinast, D. Todt, A. Stang (Bochum/DE)M. Badenhorst (Vienna/AT), K. Koeppel, A. Guthrie (Pretoria/ZA), J. Cavalleri (Vienna/AT)E. Steinmann (Bochum/DE)

P 191 Tigray virus as a genetic chimaera between rodent-borne and shrew-borne hantavirusesB. Klempa (Bratislava/SK; Berlin/DE), L. Lavrachenko (Moscow/RU), B. Auste, S. WeissS. Köndgen (Berlin/DE), K. Boršová (Bratislava/SK), D. H. Krüger (Berlin/DE)A. N. Lukashev (Moscow/RU), J. F. Drexler (Berlin/DE)

P 192 Characterization of a filovirus (Měnglà virus) from Rousettus bats in ChinaX. Yang (Wuhan/CN; Singapore/SG), C. W. Tan, D. E. Anderson (Singapore/SG), R.-D. JiangB. Li, W. Zhang, Y. Zhu (Wuhan/CN), X. Fang Lim (Singapore/SG), P. Zhou, X.-L. LiuW. Guan (Wuhan/CN), L. Zhang (Guangzhou/CN), S.-Y. Li, Y.-Z. Zhang (Dali/CN)L.-F. Wang (Singapore/SG), Z.-L. Shi (Wuhan/CN)

P 193 Human Immune responses to Lassa Virus Infection in NigeriaL. Oestereich (Hamburg/DE), E. Speranza (Hamilton, Boston, MA//US), D. M. WozniakJ. R. Port, E. Pallasch, S. Bockholt (Hamburg/DE), D. Asogun, E. Ogbaini-Emovon (Irrua/NG)M. Pahlmann, S. Duraffour, C. Munoz-Fontela (Hamburg/DE), J. Connor (Boston, MA/US)S. Günther (Hamburg/DE)

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POSTER SESSION 2

P 194 Establishment of primary neuronal cultures to study the neurotropism of Ebola and Nipah virusM. Gellhorn Serra, H. Wonneberger, S. Becker, A. Kupke (Marburg/DE)

P 195 Characterization of persistent porcine pegivirus infection: serology, transmission and replication in PBMCsJ. Kennedy, V. M. Pfankuche, D. Höltig, A. Postel, M. Ciurkiewicz, W. BaumgärtnerP. Becher, C. Bächlein (Hanover/DE)

P 196 Phosphorylation of serine 205 of influenza A virus NS1 protein as determinant of adaptation to the human hostA. Patil, Y. Boergeling, D. Anhlan, A. Mecate-Zambrano, C. Nordhoff, V. WixlerS. Ludwig (Münster/DE)

P 197 Evidence for protection from congenital Zika syndrome by maternal multi-typic dengue virus infectionsC. Fischer (Berlin/DE)

P 198 Contact-dependent transmission of Langat virusS. Schreier, K. Cebulski (Magdeburg/DE), M. Grashoff, C. Erck (Braunschweig/DE)A. Kröger (Magdeburg, Braunschweig/DE)

P 199 Novel sandfly-borne phlebovirus from NepalA. Kopp (Berlin/DE), R. Pun (Berlin, Frankfurt a. M./DE), F. Zirkel (Berlin, Bonn/DE)M. Dhimal, I. Gautam, C. L. Bhusal (Kathmandu/NP), D. A. Groneberg (Frankfurt a. M./DE) C. Drosten (Berlin/DE), U. Kuch (Frankfurt a. M./DE), S. Junglen (Berlin/DE)

P 200 Infection with a KSHV-related virus and Kaposi”s sarcoma in a mantled guerezaA. Grewer (Krefeld/DE), M. Bleyer, K. Mätz-Rensing, A. Hahn (Göttingen/DE), T. RüggebergG. Babaryka (Düsseldorf/DE), A. Zimmermann (Neuss, Düsseldorf/DE), A. KaulS. Pöhlmann (Göttingen/DE)

P 201 Inhibition of Myosin Vb-associated recycling pathways disrupts trafficking of Marburgvirus glycoproteinS. Halwe, Y. Takamatsu, S. Becker, O. Dolnik (Marburg/DE)

P 202 Impact of the polybasic cleavage site within the HA of a recent German H7N7 virus onits pathogenicity in different poultry speciesD. Scheibner, E. Abdelwhab, M. Gischke, A. Salaheldin, J. VeitsT. C. Mettenleiter (Greifswald – Isle of Riems/DE)

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P 203 Eurasian avian-like swine influenza A viruses escape human MxA restriction by distinctmutations in their nucleoproteinP. Petric (Freiburg/DE)

P 204 Avian influenza H7Nx: virus evolution and zoonotic potentialM. Naguib (Uppsala/SE), A. Mostafa (Giessen/DE), R. Li (London/GB), M. Wille (Victoria/AU) A. Graaf (Greifswald – Isle of Riems/DE), J. Verhagen (Kalmar/SE), J. Järhult, P. EllströmÅ. Lundkvist, B. Olsen (Uppsala/SE)

Structure, Assembly and EgressP 205 Dissecting human cytomegalovirus secondary envelopment by three-dimensional electron microscopyC. Read, M. Schauflinger, P. Walther, J. von Einem (Ulm/DE)

P 206 Hepatitis B Virus subverts the Autophagy Elongation Complex Atg5-12/16L1 for Viral MaturationL. Zeyen, T. Döring, C. Bartusch, R. Prange (Mainz/DE)

P 207 Surface-exposed lysine residues of the Canine Distemper Virus Matrix protein contribute to membrane association and budding activityN. P. Kadzioch, M. Gast, P. Plattet (Bern/CH)

P 208 Autophagic Degradation of Lamins Facilitates the Nuclear Egress of Herpes Simplex Virus Type-1 in Dendritic CellsL. Grosche, A. Turan (Erlangen/DE), A. Krawczyk (Essen/DE), P. Mühl-Zürbes, C. DraßnerA. Düthorn, M. Kummer (Erlangen/DE), M. Hasenberg, S. Voortmann, H. Jastrow (Essen/DE)J. Dörrie, N. Schaft, M. Kraner (Erlangen/DE), K. Döhner, B. Sodeik (Hanover/DE)A. Steinkasserer, C. S. Heilingloh (Erlangen/DE)

P 209 Virion formation of classical swine fever virus in absence of uncleaved nonstructural protein 2-3 (NS2-3)N. Tautz, S. Schwindt, H. Bischoff, O. Klemens, D. Dubrau (Lübeck/DE)

P 210 Characterization of a fast-replicating hepevirus from fish and its use as hepatitis E virus surrogateM. Bochud (Bern/CH), W. Schäfer (Marburg/DE), N. J. Roth, C. Ros (Bern/CH)

P 211 Ebola virus nucleocapsid-like structures induce actin tails for intracellular transport downstream of Rac1-signallingK. Grikscheit, Y. Takamatsu, S. Becker (Marburg/DE)

P 212 Regulatory aspects of the nuclear egress complex of human cytomegalovirusD. Horsch, E. Sonntag, S. Häge, R. Müller, U. Schlötzer-Schrehardt, M. Marschall (Erlangen/DE)

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P 213 Junín Virus Nucleoprotein Isoforms and their Functional Role in the Viral Infection CycleL. Bostedt, A. Groseth (Greifswald – Isle of Riems/DE)

P 214 Formation of semi-enveloped particles and shorter filaments as unique features of anHBV PreS1 deletion mutantB. Jiang, Q. Wu (Langen/DE), L. Kuhnhenn (Langen, Frankfurt a. M./DE), S. Akas, C. Spengler K. Boller (Langen/DE), K.-H. Peiffer (Langen, Frankfurt a. M./DE), E. Hildt (Langen/DE)

P 215 Analysis of the relevance of exosomes for the spread of hepatitis B virusQ. Wu, B. Jiang, M. Glitscher, S. Akhras (Langen/DE), E. Hildt (Langen, Giessen, Marburg/DE)

P 216 The activator-effector pair ABHD5 –ATGL draws triglycerides from the lipid droplets for HCV productionG. Vieyres, T. Pietschmann (Hanover/DE)

P 217 Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA virusesT. Holm (Prenzberg/DE), J.-D. Kopicki, C. Busch, S. Olschewski, M. Rosenthal, C. UetrechtS. Guenther (Hamburg/DE), S. Reindl (Hamburg, Biberach/Riss/DE)

P 218 Partial conservation of core NEC protein interactions compared between α-, β- and γ- herpesvirusesS. Häge, E. Sonntag, C. Wangen, Y. Muller, M. Marschall (Erlangen/DE)

P 219 The impact of Marburg virus VP40 phosphotyrosines on protein functionV. Hunszinger, L. Kolesnikova, O. Dolnik, S. Becker (Marburg/DE)

P 220 Development and characterization of monoclonal antibodies specifically detecting the herpesvirus nuclear egress complexJ. E. Hölper, B. G. Klupp, S. Reiche (Greifswald – Isle of Riems/DE)T. Ben-Mordehai (Utrecht/NL), K. Grünewald (Hamburg/DE)T. C. Mettenleiter (Greifswald – Isle of Riems/DE)

P 221 Characterization of the accessory protein 4 of human coronavirus 229EA. Friedrich, G. Tekes, J. Ziebuhr (Giessen/DE)

P 222 Time-dependent nuclear egress of herpesvirus through host chromatinS. Mattola, V. Aho (Jyväskylä/FI), E. Mäntylä (Tampere/FI), A. Ekman (Berkeley, CA/US)S. Hakanen (Jyväskylä/FI), J.-H. Chen, V. Weinhardt (Berkeley, CA/US)V. Ruokolainen (Jyväskylä/FI), B. Sodeik (Hanover/DE)C. A. Larabell (San Francisco, Berkeley, CA/US), M. Vihinen-Ranta (Jyväskylä/FI)

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P 223 Multimerisation of the KSHV capsid vertex specific component (CVSC) ORF19 protein is required for the production of infectious viral progenyE. Naimo, P. Naniima, S. Koch (Hanover, Braunschweig/DE), K. Alkharsah (Dammam/SA)T. F. Schulz, T. Krey (Hanover, Braunschweig/DE)

P 224 Exploring the Spatiotemporal Organization of human Cytomegalovirus EgressF. Flomm, T. Soh, C. Schneider, W. Ching, A. Münscher, R. Reimer (Hamburg/DE)K. Grünewald (Hamburg/DE; Oxford/GB), J. B. Bosse (Hamburg/DE)

P 225 First steps towards the mapping of the Lassa matrix protein interactome using proximity-dependent biotin identification in human cellsB. Ehlert, S. K. Fehling, T. Strecker (Marburg/DE)

P 226 Protein-protein interactions of the Ebola virus matrix protein VP40A.-D. Werner (Marburg/DE), E. Ollmann Saphire (La Jolla, FL/US), S. Becker (Marburg/DE)

P 227 Identification of host factors with a role in HTLV-1 p8 transfer between T-cellsN. Donhauser, S. Millen, M. Jeninga, S. Heym, E. Socher, J. Hofmann, H. StichtA. K. Thoma-Kress (Erlangen/DE)

P 228 Genome packaging of Influenza A virus might be regulated by NP acetylationS. Giese, K. Ciminski, H. Bolte, M. Schwemmle (Freiburg/DE)

P 229 Nuclear targeting of incoming Herpes Simplex Virus capsids and a potential interaction of the inner tegument protein pUL36 with the nucleoporin Nup358A. Cornelius, D. Otoo, A. Pohlmann, F. Anderson, K. Döhner (Hanover/DE), F. LagadecR. Kehlenbach (Göttingen/DE), B. Sodeik (Hanover/DE)

P 230 Tyrosine phosphorylation of influenza A virus matrix protein 1 is essential for efficient viral particle assemblyA. Mecate-Zambrano, G. Seebohm (Münster/DE), K. Ciminski (Freiburg/DE), A. SchreiberD. Anhlan, L. Greune, L. Wixler, S. Grothe, N. C. Stein, A. Schmidt, K. Langer (Münster/DE) M. Schwemmle (Freiburg/DE), T. Shi (Basel/CH), S. Ludwig, Y. Börgeling (Münster/DE)

P 231 Structural and functional insights of the capsid protein from Zika virusH. Song, Z. Shang, J. Qi, Y. Shi, G. F. Gao (Beijing/CN)

16. JAHRESTAGUNG der Deutschen Gesellschaft für Klinische

Chemie und Laboratoriumsmedizin e.V.

TAGUNGSPRÄSIDENT Prof. Dr. med. Berend Isermann

Otto-von-Guericke-Universität MagdeburgMedizinische Fakultät

Institut für Klinische Chemie und Pathobiochemie

Labormedizin#moderndenken

25. - 28.09.2019

Messe magdeburg

www.dgkl2019.de

DGKL2019-A6Anzeige-21122018.indd 1 21.12.2018 16:09:42

69

POSTER SESSION 216. JAHRESTAGUNG der Deutschen Gesellschaft für Klinische

Chemie und Laboratoriumsmedizin e.V.

TAGUNGSPRÄSIDENT Prof. Dr. med. Berend Isermann

Otto-von-Guericke-Universität MagdeburgMedizinische Fakultät

Institut für Klinische Chemie und Pathobiochemie

Labormedizin#moderndenken

25. - 28.09.2019

Messe magdeburg

www.dgkl2019.de

DGKL2019-A6Anzeige-21122018.indd 1 21.12.2018 16:09:42

70

POSTER SESSION 2

VaccinesP 232 Porcine epidemic diarrhea vaccine evaluation using a newly isolated strain from KoreaH.-J. Shin (Taejon/KR)

P 233 Impairment of TBE vaccine-induced antibody response by previous yellow fever vaccinationV. Bradt, J. Jarmer, S. Malafa, G. Tsouchnikas, I. Medits (Vienna/AT)U. Karrer (Zurich, Winterthur/CH), K. Stiasny, F. X. Heinz (Vienna/AT)

P 234 Nutritional requirements of animal component-free cell culture media for optimal foot-and-mouth disease virus production in BHK-2P suspension cellsV. Dill (Greifswald – Isle of Riems/DE), A. Zimmer (Darmstadt/DE), M. BeerM. Eschbaumer (Greifswald – Isle of Riems/DE)

P 235 Development of a novel ORFV-based therapeutic cancer vaccine for the treatment of papillomavirus-induced tumorsM. Schneider, M. Müller, A. Yigitliler, J. Xi, T. Feger, H.-J. Rziha, H.-G. RammenseeF. Stubenrauch, T. Iftner, R. Amann (Tübingen/DE)

P 236 Evaluation of a new, VLP-based vaccine against infectious laryngotracheitis (ILT)J. Schädler, B. Sigrist, N. Wolfrum (Zurich/CH)

P 237 VSV-GP as vaccine vector for RSVS. Wilmschen, S. Schneider (Innsbruck/AT), L. Bayer, J. Gümpel, T. Grunwald (Leipzig/DE)D. von Laer, J. Kimpel (Innsbruck/AT)

P 238 Reinforcing the cytotoxic CD8+ T-cell response by a peptide based nanoparticle vaccine elicits type I interferon dependent control of chronic retroviral infectionT. Knuschke, S. Kollenda, W. Bayer, K. Sutter, G. Zelinskyy, U. Dittmer, K. Lang, M. EppleJ. Buer, A. Westendorf (Essen/DE)

P 239 Development of a Lactobacillus-based local HIV-1 prevention with broadly neutralizing nanobodiesS. Kalusche, K. Koch, F. Lehmann (Frankfurt a. M./DE), H. Grüll (Cologne/DE)U. Wernery (Dubai/AE), H. Marcotte (Stockholm/SE), F. Klein (Cologne/DE)U. Dietrich (Frankfurt a. M./DE)

P 240 Systemic prime and mucosal boost immunization effectively protects against viral respiratory tract infectionsJ. Fuchs, D. Lapuente, C. Maier, P. Irrgang (Erlangen/DE), C. Thirion (Martinsried/DE)M. Tenbusch (Erlangen/DE)

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POSTER SESSION 2

P 241 Primary RSV Infection and adenoviral vector immunization induce distinct inflammatory profiles and immune responsesC. Maier, D. Lapuente, J. Fuchs, P. Irrgang, M. Tenbusch (Erlangen/DE)

P 242 Detection of chikungunya virus-specific CD8+T-cells in participants of a phase 1 clinicaltrial with a measles virus-based vaccineK. Schmitz, A. Comvalius (Rotterdam/NL), R. Tschismarov (Vienna/AT)B. E. Martina (Rotterdam/NL), J. Aberle (Vienna/AT), R. D. de VriesR. L. de Swart (Rotterdam/NL)

P 243 Development of a new approach for therapeutic vaccination against chronic HBV infectionT. Zahn, S. Akhras (Langen/DE), E. Hildt (Langen, Braunschweig/DE)

P 244 Development of a heat-stable therapeutic MVA-based prime/boost vaccine to combat chronic hepatitis BJ. Sacherl, K. Singethan, A. Kosinska (Munich/DE), K. Kemter (Martinsried/DE), M. KächeleS. Essbauer (Munich/DE), J. Altrichter (Martinsried/DE), U. Protzer (Munich/DE)

P 245 Novel chimeric marker vaccines against Classical swine fever virus provide full protection and improved differentiation of infected from vaccinated animalsA. Postel, P. Becher (Hanover/DE)

P 246 Novel HIV-1 clade C Envelope trimers as vaccine candidates exhibit optimal antigenic profiles in vitro and in vivoA. Hauser, D. Peterhoff, T. Hartinger, M. Schachtner (Regensburg/DE), N. FriedrichA. Trkola (Zurich/CH), C. Moog (Strasbourg/DE), W. Weissenhorn (Grenoble/FR)Q. Sattentau (Oxford/GB), R. Sanders (Amsterdam/NL), R. Wagner (Regensburg/DE)

P 247 Effective and protective immunization with a novel recombinant MERS-CoV expressedin CHO cells for developing subunit vaccineS. Kim, Y. Park, S. Kim, J. Jang, E. Lee, G. Ryoo, H. Jang (Yesan/KR)

P 248 Development of germline-targeting hepatitis C virus (HCV) immunogens as vaccine candidatesB. Veselkova, L. Stroeh, D. Bankwitz (Hanover/DE), L. Dold, F. Klein (Cologne/DE)T. Pietschmann, T. Krey (Hanover/DE)

P 249 A Recombinant Glycoprotein L-Deficient Gamma-2 Herpesvirus Establishes Persistent Infection in Rhesus Macaques and Elicits Conventional T-cell ResponsesA. Hahn (Göttingen/DE), G. Bischof (Miami, FL/US), A. Großkopf (Göttingen/DE), M. Martins Y. Shin, A. Domingues (Miami, FL/US), E. Rakasz (Madison, WI/US), A. Ensser (Erlangen/DE)R. Desrosiers (Miami, FL/US)

72

POSTER SESSION 2

P 250 An oncolytic herpes simplex virus 1 expressing MelanA kills melanoma cells via direct and indirect effectsJ. B. Boscheinen, S. Thomann (Erlangen/DE), D. M. Knipe (Boston, MA/US)N. DeLuca (Pittsburgh, PA/US), B. Schuler-Thurner, S. Gross, J. Dörrie, N. SchaftC. Bach (Erlangen/DE), A. Rohrhofer, M. Werner-Klein, B. SchmidtP. Schuster (Regensburg/DE)

P 251 Induction of HIV Neutralizing Antibodies by Envelope Trimers Incorporated Into a Highly ReplicationJ. Kimpel, C. A. Bresk (Innsbruck/AT), A. Hauser (Regensburg/DE), T. Hofer, S. WilmschenM. Krismer, A. Beierfuß (Innsbruck/AT), G. Effantin, W. Weissenhorn (Grenoble/FR)R. S. Gelman (Boston, MA/US), D. C. Montefiori, H.-X. Liao (Durham, NC/US)J. E. Schmitz (Boston, MA/US), B. F. Haynes (Durham, NC/US), R. Wagner (Regensburg/DE) D. von Laer (Innsbruck/AT)

P 252 Single-Dose of a Recombinant Vesicular Stomatitis Virus-Based Vaccine Elicits Complete Protection against Severe Fever with Thrombocytopenia Syndrome VirusA. Zheng (Beijing/CN)

P 253 Protecteotype efficacy of some commercial infectious bronchitis virus (IBV) live-attenuated vaccines against field classic and variant IBV challenges in EgyptM. A. Afifi, S. A. Zoelfakkar, E. A. Morsy, H. A. Salem, H. H. Abozeid, K. A. AhmedM. A. Helmy (Cairo/EG)

P 254 Introduction of underrepresented codon pairs, but not CpG dinucleotides, into the influenza A virus neuraminidase gene causes virus attenuation in vitroD. Kunec, N. Groenke, N. Osterrieder (Berlin/DE)

P 255 Characterization of HIV vaccine candidates based on their capability to induce humoral immune responses in a rabbit modelT. Hartinger, A. Hauser, D. Peterhoff (Regensburg/DE), C. Moog (Strasbourg/FR)Q. Sattentau (Oxford/GB), R. Sanders (Amsterdam/NL), R. Wagner (Regensburg/DE)

P 256 Efficacy of some Infectious Bursal disease (IBD) vaccines against recently isolated vvIBD virusM. A. Afifi, S. A. Zoelfakar, H. M. Salem, E. A. Morsy, K. A. Ahmed,A.-A. G.A. M. A. Helmy (Cairo/EG)

73

POSTER SESSION 2

Viral Receptors and EntryP 257 Structural and functional comparison of glycoprotein B fusion loops of Pseudorabiesand Herpes Simplex virusM. Vallbracht, B. G. Klupp (Greifswald – Isle of Riems/DE), F. A. Rey, M. Backovic (Paris/FR)T. C. Mettenleiter (Greifswald – Isle of Riems/DE)

P 258 Determining the proviral function of cathepsin W in influenza A virus entryS. C. Günther, S. Stertz (Zurich/CH)

P 259 Herpes Simplex Virus 1 can switch its entry into fibroblasts from dynamin-dependent to dynamin-independent pathwaysM. Möckel, E. Rahn, N. De La Cruz, L. Wirtz (Cologne/DE), J. van LentG. Pijlman (Wageningen/NL), D. Knebel-Mörsdorf (Cologne/DE)

P 260 Invasion of Herpes simplex virus 1 into murine dermisL. Wirtz, D. Knebel-Mörsdorf (Cologne/DE)

P 261 Cholesterol binding to the transmembrane region of a group 2 HA of Influenza virus isessential for virus replication affecting virus assembly and HA´s fusion activityB. Hu, C. T. Höfer (Berlin/DE), C. Thiele (Bonn/DE), M. Veit (Berlin/DE)

P 262 MHC class II proteins are cross-species entry receptors for bat influenza virusesT. Thamamongood (Freiburg/DE), U. Karakus (Zurich/CH), K. Ciminski, R. Wei (Freiburg/DE) J. Wiener (Neuherberg/DE), C. Jeney (Freiburg/DE), M. Meier (Neuherberg/DE)G. Zimmer (Mittelhäusern/CH), D. Hoffmann, J. Schinköthe (Greifswald – Isle of Riems/DE) M. W. Chang (San Diego La Jolla, FL/US), R. Ulrich (Greifswald – Isle of Riems/DE)C. Benner (San Diego La Jolla, FL/US), M. Beer (Greifswald – Isle of Riems/DE)A. Garcia-Sastre (New York, NY/US), B. G. Hale, S. Stertz (Zurich/CH)M. Schwemmle (Freiburg/DE)

P 263 Impact of genotype on hepatitis B virus life cycleQ. Wu, B. Jiang, C. Spengler (Langen/DE), E. Hildt (Giessen, Marburg, Langen/DE)

P 264 Characterizing the role of α-taxilin for the Hepatitis B virus entry processC. Spengler, F. Elgner (Langen/DE), E. Hildt (Langen, Braunschweig/DE)

P 265 Natural inhibitor of human cytomegalovirus in human seminal plasmaS. Lippold, B. Braun, F. Krüger, M. Harms, J. A. Müller, R. Groß, J. MünchJ. von Einem (Ulm/DE)

P 266 Native mass spectrometry analysis of norovirus glycan interactionH. Yan (Hamburg/DE), K. Bücher (Düsseldorf/DE), R. Creutznacher, A. MallagarayT. Peters (Lübeck/DE), L. Hartmann (Düsseldorf/DE), C. Uetrecht (Hamburg, Schenefeld/DE)

74

POSTER SESSION 2

P 267 Regulation of the transferrin receptor recycling in HCV-replicating cellsV. Haberger, E. Hildt, F. Elgner (Langen/DE)

P 268 Interactions between Zika virus and the host – Epidermal Growth Factor Receptor mediates Zika virus entryC. Sabino (Langen/DE), E. Hildt (Langen, Braunschweig/DE)

P 269 Phosphorylation events in early steps of influenza virus infectionA. Hunziker, S. Stertz (Zurich/CH)

P 270 Proteolytic activation of the fusion glycoprotein of a bat-derived mumps virusS. Hüttl (Hanover/DE), C. Sauder, S. Rubin (Silver Spring, MD/US)M. Hoffmann (Göttingen/DE), N. Krüger (Hanover/DE)

P 271 Differential effect of Ghanaian bat Henipavirus G protein domains on surface expression and fusion activityK. Voigt (Hanover/DE), M. Hoffmann (Göttingen/DE), M. A. Müller, J. F. DrexlerC. Drosten (Berlin/DE), G. Herrler, N. Krüger (Hanover/DE)

P 272 Interaction between interferon-induced transmembrane proteins and gamma2-Herpes virusesB. Hörnich, C. D‘Costa, S. Schlagowski, S. Pöhlmann, A. Großkopf, A. Hahn (Göttingen/DE)

P 273 Effects of N-glycans in positions 63 and 81 of the hemagglutinin on properties and replication efficiency of H3N2/1968 pandemic influenza virusesJ. Beicht, J. West, J. Röder, J. Baumann, J. Doedt, N. Mounogou Kouassi, T. MatrosovichH.-D. Klenk, M. Matrosovich (Marburg/DE)

P 274 Structural characterization of gamma-2 herpesvirus glycoprotein entry receptor complexesT. Fricke, A. K. Großkopf, C. Cretu (Göttingen/DE), R. C. Desrosiers (Miami/US), V. PenaA. S. Hahn (Göttingen/DE)

P 275 Inhibitory effect of soluble forms of trimer- and pentamer-specific receptors for different HCMV gO genotype mutant strainsJ. Kalser, N. Brait (Vienna/AT), B. Adler (Munich/DE), T. Stögerer, I. Kunz, E. PuchhammerI. Görzer (Vienna/AT)

P 276 Identification of a receptor binding site of the human endogenous retrovirus HERV-K(HML-2)H. Al-shehabi, O. Hohn, J. Wamara, N. Bannert (Berlin/DE)

75

POSTER SESSION 2

P 277 EphA7 functions as a receptor for cell-to-cell transmission of Kaposi’s sarcoma-associated herpesvirus into BJAB B cells and for cell-free virus infection by therelated rhesus monkey rhadinovirusA. K. Großkopf, S. Schlagowski, B. F. Hörnich, T. Fricke (Göttingen/DE)R. C. Desrosiers (Miami, FL/US), A. S. Hahn (Göttingen/DE)

P 278 Relating structure and function in heparan sulfate-papillomavirus interactionsD. Pahl, Y. Korpys (Tübingen, Münster/DE), J. Dülfer, R. PoganH. Yan (Hamburg, Tübingen/DE), D. Hurdiss (Leeds/GB), I. Lopez de Blas (Groningen/NL)A. Macdonald (Leeds/GB), W. H. Roos (Groningen/NL), C. Uetrecht (Hamburg, Tübingen/DE) M. Schelhaas (Münster, Tübingen/DE)

P 279 Co-infection of porcine differentiated airway cells by swine influenza virus and porcine respiratory coronavirusJ.-Y. Peng (Hanover/DE), D. Punyadarsaniya (Bangkok/TH)N.-H. Wu (Hanover/DE; Bangkok/TH), D.-L. Shin, G. Herrler (Hanover/DE)

P 280 Importance of the receptor binding affinity of avian and human influenza viruses for growth on the swine airway epithelial cellsD.-L. Shin, N.-H. Wu, J.-Y. Peng, G. Herrler (Hanover/DE)

P 281 Importin α5 is required for efficient nuclear targeting of incoming HSV capsids in neuronsK. Döhner, A. Hickford-Martinez, M. Serrero, F. Anderson, D. Bialy, A. BuchN. Brückner (Hanover/DE), F. Rother (Berlin-Buch, Lübeck/DE), L. de Vries (Hamburg/DE)R. J. Lebbink (Utrecht/NL), R. C. Hoeben (Leiden/NL), J. B. Bosse (Hamburg/DE)E. Hartmann (Lübeck/DE), M. Bader (Berlin-Buch, Lübeck/DE), R. BauerfeindB. Sodeik (Hanover/DE)

P 283 Characterization of the Infection of differentiated Airway Epithelial Cells by Bovine viral diarrhea (BVD) VirusA. Su, G. Herrler, P. Becher (Hanover/DE)

P 284 Identification of a mutation in the Ebola virus glycoprotein that reduces the dependence of host cell entry on cellular cysteine proteasesM. Hoffmann, S. V. Kaufmann, C. Fischer, W. Maurer, S. Pöhlmann (Göttingen/DE)

P 285 Inhibition of Tetraspanin Functions Impairs Human Papillomavirus and Cytomegalovirus InfectionsL. Fast, S. Mikuličić, A. Fritzen, J. Schwickert, F. Boukhallouk (Mainz/DE), D. HochdorferC. Sinzger (Ulm/DE), H. Suarez (Madrid/ES), P. N. Monk (Sheffield/GB)M. Yáñez-Mó (Madrid/ES), D. Lieber (Ulm/DE), L. Florin (Mainz/DE)

76

POSTER SESSION 2

P 286 Genetic fusion of peste des petits ruminants virus haemagglutinin and fusion protein domains to the amino terminal subunit of glycoprotein B of bovine herpesvirus 1 interferes with transport and function of gB for BHV-1 infectious replicationN. A. Osman (Khartoum-North/SD; Greifswald – Isle of Riems/DE), A. Roeder, K. GiesowG. Keil (Greifswald – Isle of Riems/DE)

P 287 Influenza virus entry, neutralization and replicationY. Shi (Beijing/CN)

P 288 Improved delivery of tumor specific oncolytic adenovirus type 5 with NK-92 carrier cells in cancer treatmentJ. Gao, E. Ehrke-Schulz, W. Zhang, M. Schiwon, K. Mese, A. Ehrhardt (Witten/DE)

P 289 A simple DNA-based reverse genetics system and novel plaque assay for murine norovirusesM. Lingemann, A. Schoelzel, S. Taube (Lübeck/DE)

P 290 Entry driven by filovirus glycoproteins depends on cathepsin B/L activity irrespective of particle shape and target cell species and can be limited by low endogenous cathepsin L expressionM. González-Hernández, M. Hoffmann, S. Pöhlmann (Göttingen/DE)

P 291 The CXCR4-blocking albumin fragment EPI-X4 is present at sites of HIV-1 transmissionM. Harms, O. Zirafi (Ulm/DE), O. T. Keppler (Munich/DE), F. Klein, K. Vanshylla (Cologne/DE) F. Kirchhoff, J. Münch (Ulm/DE)

P 292 Alphaherpesviruses require activation of small GTPases: Role of Cdc42 and Rac1 in virus pathogenesisO. Kolyvushko, W. Azab (Berlin/DE)

Viral Vectors and Gene TherapyP 293 Characterization of replication competent high capacity murine cytomegalovirus vectorsA. Riedl, D. Bojková, S. Naumann, C. Jeney, Z. Ruzsics (Freiburg/DE)

P 294 Enhanced genome engineering by transient prototype foamy virus vector-mediated (TraFo) delivery of CRISPR/Cas9F. Lindel, C. Dodt, N. Weidner, M. Noll, F. Bergemann, R. Behrendt, S. Fischer, M. Hamann D. Lindemann (Dresden/DE)

P 295 Screening of reporter gene expressing human adenovirus types with regard to their use as oncolytic/cancer gene therapy vectors for HPV associated cancersL. Schulte, E. Ehrke-Schulz, W. Zhang, A. Ehrhardt (Witten/DE)

77

POSTER SESSION 2

P 296 Insertion and expression of heterologous gene sequences in the vaccinia virus F11L gene locusM. H. Lehmann, C. Brandmüller, G. Sutter (Munich/DE)

Epidemiology and Public HealthP 297 isolation and identification of enterovirus d111 in a child with acute Flaccid Paralysis in NigeriaT. Faleye (Ado-Ekiti/NG), M. Adewumi, O. Olayinka, J. Adeniji (Ibadan/NG)

P 298 Attempted reconstruction of transmission pathways in outbreaks of low pathogenic avian influenza viruses of subtype H5N3 in commercial turkey fattening holdings in Germany (2008-2009)A. Graaf (Greifswald – Isle of Riems/DE), H. Leßmann (Cloppenburg/DE)A. Moss (Wardenburg/DE), M. Beer, T. C. Harder (Greifswald – Isle of Riems/DE)

P 299 Influenza, Malaria and Typhoid Coinfection: Seroepidemiologic Investigation among Children attending Four Healthcare Centres in Lagos, NigeriaA. A. Anjorin, S. R. Babalola, O. P. Iyiade (Lagos/NG)

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POSTER SESSION 3

P 300 Potential threats from Emerging and re-emerging tick-borne viruses in Xinjiang Uygur Autonomous Region, ChinaS. Shen (Wuhan/CN), A. Moming, J. Zhang (Wuhan, Urumqi/CN), T. Luo (Urumqi/CN)C. Chang (Urumqi, Wuhan/CN), Y. Fang, J. Wang (Wuhan/CN), C. Kou (Wuhan, Urumqi/CN) C. Wang (Urumqi/CN), Z. Su, Y. Zhang, S. Tang, Q. Wu (Wuhan/CN)X. Duan (Wuhan, Urumqi/CN), L. Zhu (Wuhan/CN), R. An (Urumqi/CN), J. Shi, J. YangZ. Zhang, J. Liang, Y. Bai (Wuhan/CN), R. Guo (Urumqi/CN), Z. Fan, H. Wang (Wuhan/CN)Y. Zhang, S. Sun (Urumqi/CN), Z. Hu, F. Deng (Wuhan/CN)

P 302 Viral gastroenteritis among children of 0-5 years in Nigeria: Characterization of the first Nigerian aichivirus, recombinant noroviruses and detection of a zoonotic astrovirusM. O. Japhet (Berlin/DE; Ile-Ife, Ado-Ekiti/NG), O. Famurewa (Ado-Ekiti, Odeomu/NG)O. A. Adesina (Ile-Ife/NG), O. O. Opaleye (Osogbo/DE), B. Wang, M. Höhne, T. BockA. Mas Marques, S. Niendorf (Berlin/DE)

P 304 Enterovirus-Surveillance in GermanyK. Keeren, S. Böttcher (Berlin/DE), F. Feil, K. Beyrer (Hanover/DE), S. Diedrich (Berlin/DE)

P 305 Inactivation and removal of Chikungunya and Mayaro virusC. Yue, H. Roth, S. Baylis, J. Blümel (Langen/DE)

P 307 Testing for host-virus co-divergence and cross-species events in the polyomaviruses ofAfrican great apesA. Aghebatrafat, F. H. Leendertz, S. Calvignac-Spencer (Berlin/DE)

Host Cell Factors for ReplicationP 308 Correlation between Virus Replication and NPC1 Receptor Expression in a Potential Bat Reservoir of Ebola virusM. Bokelmann, K. Edenborough, P. Kreher, U. Vogel, A. Lander (Berlin/DE)E. Couacy-Hymann (Bingerville/CI), A. Kurth (Berlin/DE)

P 309 Mammalian haploid cell screen to identify host factors essential for Rift Valley fever virusP. Schmerer, S. Devignot (Giessen/DE), A. Leibbrandt, T. R. Burkhard, U. EllingJ. Penninger (Vienna/AT), F. Weber (Giessen/DE)

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P 310 Functional characterization of a second interaction site of Brd4 with HPV31 E2A. Yigitliler, M. Schneider (Tübingen/DE), C. M. Chiang (Dallas, TX/US), F. StubenrauchT. Iftner (Tübingen/DE)

P 311 The DEAD-Box RNA Helicase eIF4A as a novel broad-spectrum Antiviral TargetA. Grünweller, W. Obermann (Marburg/DE), C. Müller (Giessen/DE), F. W. SchulteK. Lange-Grünweller (Marburg/DE), J. Ziebuhr (Giessen/DE), R. K. Hartmann (Marburg/DE)

P 312 An experimental pipeline to investigate sites of post-translational regulation of SAMHD1M. Schüssler, K. Schott, N. Hein-Fuchs (Langen/DE), R. Derua, V. Janssens (Leuven/BE)R. König (La Jolla, CA/US; Langen/DE)

P 313 SAMHD1 – regulation of DNA end resection at DNA double strand breaks and stalled replication forksC. Majer (Langen/DE), M. Rall-Scharpf (Ulm/DE), K. Schott, N. Hein-FuchsM. Schüßler (Langen/DE), L. Wiesmüller (Ulm/DE), R. König (Langen/DE)

P 314 Characterization of interaction properties between the HCMV protein kinase pUL97 and other herpesviral CDK orthologs with human cyclinsS. Kohrt, M. Steingruber, E. Socher, H. Sticht, M. Marschall (Erlangen/DE)

P 316 Decoding of the pathogen induced cell signaling identifies CDK6 as a novel restrictionfactor of Hepatitis E virusV. Kinast (Bochum/DE), P. Behrendt (Hanover/DE), D. Todt, E. Steinmann (Bochum/DE)

P 317 ZIKV Interference with the Tetherin SystemM.-L. Herrlein, P. Schmanke, F. Elgner, S. Akhras, D. Bender, K. Himmelsbach (Langen/DE) D. Tabari, C. Scholl, J. Stingl (Bonn/DE), E. Hildt (Langen, Braunschweig/DE)

P 318 Upregulation of DHHC-22 palmitoyltransferase upon influenza virus infectionM. R. Gadalla (Berlin/DE; Cairo/EG), E. Morrison, X. Han (Berlin/DE)L. Kordyukova (Berlin/DE; Moscow/RU), C. Freund, M. Veit (Berlin/DE)

P 319 Lipid droplet biogenesis regulates HCV RNA replicationG. Vieyres, F. Vondran, T. Pietschmann (Hanover/DE)

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P 320 Knockdown of the lipid droplet coat protein PLIN2 causes ultrastructural alterationsthat correlate with impaired infectious HCV particle productionV. Nguyen-Dinh (Marburg, Hamburg/DE), S. Lassen, C. Grüttner (Hamburg/DE)E. Herker (Marburg, Hamburg/DE)

P 321 Hepatitis E virus life cycle and egress are reliant on homeostasis of sphingomyelin andcholesterolM. Glitscher, K. Himmelsbach, F. Tebbe, M. Plath (Langen/DE), D. Tabari, C. SchollJ. Stingl (Bonn/DE), E. Hildt (Langen, Braunschweig/DE)

P 322 Activation of influenza B virus by hemagglutinin-cleaving proteases present in human and murine airwaysA. Harbig, H. Limburg, J. Jäger, M. Mernberger, A. Nist, R. Heindl (Marburg/DE), D. A. Stein H. Moulton (Beaverton, OR/US), E. Böttcher-Friebertshäuser (Marburg/DE)

P 323 High glucose inhibits HBV replication through modulating AMPK/mTOR/ULK1-induced autophagy and YAP localizationX. Wang, Y. Lin (Essen/DE), S. Liu (Essen/DE; Wuhan/CN), M. Lu (Essen/DE)

P 324 Let’s replicate! - Characterization of human coronavirus 229E-induced replicative organellesC. Müller, M. Hardt, J. Ziehuhr (Giessen/DE)

P 325 Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous retrovirus (PERV) in non-dividing cellsH. Al-shehabi, H. Hofmann, U. Fiebig (Berlin/DE), J. Kutzner (Heidelberg/DE) J. Denner (Berlin/DE), T. Schaller (Heidelberg/DE), N. Bannert (Berlin/DE)

P 326 Studies on the Interaction of Rotavirus non structural proteins NSP5, NSP2 with host cellular factors and their role in virus replicationV. Tandra, C. D. Rao (Bangalore/IN)

P 327 Inhibition of ULK1 kinase activity impairs the release of viral particles from HCMV-infected cellsP. König (Ulm/DE), A. Svrlanska, S. Feichtinger (Erlangen/DE), T. Stamminger (Ulm/DE)

P 328 CHIKV replication is regulated by ARTD10-mediated mono-ADP-ribosylationS. Krieg, C. Preisinger, M. Bütepage, L. Eckei, B. Lippok, B. Lüscher, P. Verheugd (Aachen/DE)

P 329 The role of RNA binding proteins in Herpes simplex virus 1 infectionE. Wyler (Berlin/DE), A. Whisnant (Würzburg/DE), J. Voß (Berlin/DE)J. Menegatti (Homburg/Saar/DE), M. Kirchner, P. Mertins (Berlin/DE)F. Grässer (Homburg/Saar/DE), L. Dölken (Würzburg/DE), M. Landthaler (Berlin/DE)

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P 330 Analysis of Chromatin Modifications in HSV-1-Induced poly(A) ReadthroughL. Djaković, T. Hennig, F. Erhard, L. Dölken (Würzburg/DE)

P 331 Early but not late gestational influenza leads to the elevation of later life disease markers in mother and offspringH. Jacobsen, L. Scholl, K. Walendy-Gnirss, G. Gabriel (Hamburg/DE)

P 332 The role of SAMHD1 in HIV sensing and restrictionA. Herrmann, S. Wittmann, R. Behrendt, T. Gramberg (Erlangen/DE)

P 333 Identification of Annexin A3- and Perilipin 2-Interacting Proteins in Hepatitis C Virus Infected Cells Using the Proximity Labeling Methods BioID2 and APEX2H. Bley (Hamburg/DE), E. Herker (Hamburg, Marburg/DE)

P 334 Molecular Interactions of HCV Core and the Long Interspersed Nuclear Element 1 (LINE1) ORF1 Protein at HCV Assembly SitesA. Schöbel (Hamburg/DE), G. G. Schumann (Langen/DE), E. Herker (Hamburg, Marburg/DE)

P 335 Label-free quantitative proteomics of UUKV-host cell interactions reveals GBF1 as a cellular factor important for infection by a broad range of RNA virusesR. Moeller (Hanover/DE), Z. Uckeley, C. Robens (Heidelberg/DE), L. Lasswitz (Hanover/DE) A. Lenman (Umeå/SE), V. Passos (Hanover/DE), L. I. Kühn (Martinsried/DE), Y. VossC. Sommerauer, M. Kampmann (Heidelberg/DE), C. Goffinet (Hanover/DE)A. Oeverby (Umeå/SE), F. Meissner (Martinsried/DE), P.-Y. Lozach (Heidelberg/DE)G. Gerold (Hanover/DE; Umeå/SE)

P 336 Cyclophilin A usage patterns by non M HIV-1 groups, HIV-2AB and SIVgorA. P. Twizerimana, Z. Zhang, D. Häussinger, C. Münk (Düsseldorf/DE)

P 337 Interplay of Coronavirus Nsp3 with host factorsY. Ma-Lauer (Munich, Lübeck/DE), J. Lei, R. Hilgenfeld (Lübeck/DE)A. von Brunn (Munich/DE)

P 339 Genetic determinants of severe respiratory syncytial virus infections in infantsS. Haid, M. Wetzke (Hanover/DE), C. Lauber (Dresden/DE), D. Todt (Hanover, Bochum/DE) C. Grethe (Hanover/DE), R. Geffers (Braunschweig/DE)L. Kaderali (Greifswald – Isle of Riems/DE), B. Wiegmann (Hanover/DE)E. Steinmann (Hanover, Bochum/DE), T. F. Schulz, G. Hansen, T. Pietschmann (Hanover/DE)

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P 340 The cytosolic phospholipase A2 gamma facilitates the association of HCV replication and assembly sitesR. Pei, C. Dan, S. Xi, H. Xue, W. Chunchen, W. Yun, C. Yinwen (Wuhan/CN)

P 341 Up-regulation of HBV transcription by sodium taurocholate cotransporting polypeptide at the post-entry step is inhibited by the entry inhibitor Myrcludex BC. Wu (Wuhan/CN), Z. Kaitao, L. Shuhui (Wuhan, Beijing/CN)C. Yingshan (Beijing, Wuhan/CN), Y. Yongxuan (Wuhan, Beijing/CN), Z. Ming (Shenzhen/CN) Y. Yifei (Beijing, Wuhan/CN), W. Yun, P. Rongjuan, C. Jizheng, H. Xue, Z. YuanZ. He (Wuhan/CN), L. Mengji (Essen/DE), C. Xinwen (Wuhan, Beijing/CN)

P 342 Feline Morbillivirus Type 2 (FeMV-2) Infects Primary Cells of the Lung, Kidney, Brain and Peripheral BloodM. Sieg, J. Busch, M. Eschke, D. Böttcher, K. Heenemann (Leipzig/DE)A. Vahlenkamp (Böhlen/DE), A. Reinert, J. Seeger, R. Heilmann, K. SchefflerT. Vahlenkamp (Leipzig/DE)

P 343 Identification of interacting partners of guinea pig-adapted Marburg virus protein VP40-D184N using proximity-dependent biotinylationM. Klüver, A. Koehler, T. Glatter (Marburg/DE), A. Weber (Giessen/DE)U. Linne (Marburg/DE), M. Kracht (Giessen/DE), L. Kolesnikova, S. Becker (Marburg/DE)

P 344 Comparative proteomic analysis reveals the role of ORF2 and UL43 in regulating MAPK and Chemokine signalling pathways during herpesvirus infectionP. Selvaraj, H. Stephanowitz, F. Liu, W. Azab (Berlin/DE)

P 345 The host nonsense-mediated mRNA decay machinery does not block the propagationof negative-strand RNA virusesV. Q. G. Tran, H. F. Preugschas, D. Anhlan, A. Christersson-Wiegers, C. Ehrhardt, S. Ludwig E. R. Hrincius (Münster/DE)

P 346 SEC14L2 promotes HCV RNA replication by modulating Phosphatidylinositol 4-phosphate concentration in hepatoma cellsC. Schenk, T. Kehrer (Heidelberg/DE), S. Ciesek (Essen/DE), V. Lohmann (Heidelberg/DE)

P 347 Mouse cytomegalovirus M28 protein is a host range factor that inhibits EGF receptorsignaling by interacting with SHC1K. Pawletko (Hamburg/DE), S. Loroch (Dortmund/DE), D. Indenbirken (Hamburg/DE)A. Sickmann (Dortmund/DE), E. Ostermann, W. Brune (Hamburg/DE)

P 348 Modulation of hypoxia pathways during HAdV infectionS. Masser, J. Maaz, P. Groitl, J. Mai, S. Hofmann (Neuherberg, Munich/DE)J. McKeating (Neuherberg, Munich/DE; Oxford/GB), S. Schreiner (Neuherberg, Munich/DE)

REFERENCE INSTITUTEFOR BIOANALYTICS

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We develop and provideprofi ciency tests compliantwith German guidelines(Rili-BÄK)Accredited in accordance withDIN ISO 17043 and DIN ISO 17025 www.rfb.bio

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83

POSTER SESSION 3REFERENCE INSTITUTEFOR BIOANALYTICS

EQAS MADE IN GERMANY

We develop and provideprofi ciency tests compliantwith German guidelines(Rili-BÄK)Accredited in accordance withDIN ISO 17043 and DIN ISO 17025 www.rfb.bio

[email protected] Friesdorfer Str. 153 53175 Bonn Phone: +49 228 926 895 0

84

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P 349 Identifying novel cytosolic factors interacting with viral capsidsM. Serrero, A. Hickford-Martinez (Hanover/DE), T. Greco (Princeton, NJ/US)K. Döhner (Hanover/DE), I. Cristea (Princeton, NJ/US), B. Sodeik (Hanover/DE)

P 350 Ubiquitination of the Influenza A Virus Protein NS1F. Günl, T. Krischuns, J. Janowski, S. Leidel, H. Drexler, S. Ludwig, L. Brunotte (Münster/DE)

P 351 Myeloid-specific determinants of HCMV tropismG. Frascaroli, J. Tang, W. Brune (Hamburg/DE)

P 352 The Alpha and the Gamma of Latency Establishment: Deciphering early events after nuclear entry of herpesvirus genomesH. Maier, T. Günther, J. Bosse, K. Grünewald, A. Grundhoff (Hamburg/DE)

Host Cell Modulation and OncogenesisP 353 Human papillomavirus type 8 modulates the PI(4,5)P2 metabolism and causes enhanced phospholipidation of nuclear proteins.B. Marx, M. Hufbauer, P. Zigrino (Cologne/DE), S. Majewski (Warsaw/PL)B. Markiefka (Cologne/DE), T. Sachsenhauser, B. Brügger (Heidelberg/DE)B. Akgül (Cologne/DE)

P 354 A gammaherpesviral tegument protein inhibits the DNA damage responseD. Jungnickl, F. Full, B. Scholz (Erlangen/DE), A. Großkopf, A. Hahn (Göttingen/DE)A. Ensser (Erlangen/DE)

P 355 Modulation of the IL-6 Signaling Pathway in Herpes Simplex Virus Type-1-Infected Mature Dendritic CellsA. Düthorn, P. Mühl-Zürbes, C. Draßner, F. Winkler, A. SteinkassererL. Grosche (Erlangen/DE)

P 357 The Hepatitis C Virus induces CXC chemokine expression in response to the inflammatory cytokines TNFα and Il1βK. Rufinatscha, S. Stindt, J. Dobner, D. Häussinger, J. G. Bode (Düsseldorf/DE)

P 358 Tacaribe virus induces classical intrinsic apoptosis by activating BH3-only proteinsJ. Holzerland (Greifswald – Isle of Riems/DE), L. Banadyga (Winnipeg/CA)A. Groseth (Greifswald – Isle of Riems/DE)

P 359 Sofosbuvir induces changes in cell cycle distribution by upregulation of B-MYB and EGFRD. Bojkova, S. Westhaus, L. Timmer, M. Korencak, H. Streeck, K. Lang, R. BröringS. Heinrichs, F. Vondran, S. Ciesek (Essen/DE)

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P 360 The cytomegaloviral vCDK pUL97 differentially interacts with three types of human cyclins based on individual binding properties resulting in regulatory consequencesM. Steingruber, L. Keller, E. Socher (Erlangen/DE), S. Ferre, A.-M. HesseY. Couté (Grenoble/FR), F. Hahn (Erlangen/DE), N. Büscher, B. Plachter (Mainz/DE)H. Sticht, M. Marschall (Erlangen/DE)

P 362 Comparative characterization of the regulatory protein HBx derived from different hepatitis B virus genotypesB. Jiang, F. Reuter, Q. Wu (Langen/DE), K.-H. Peiffer (Langen, Frankfurt/DE)E. Hildt (Langen/DE)

P 363 A paracrine NF-κB-dependent signalling loop is required for STAT3-activation and p63-positive stem cell expansion in HPV-transformed epitheliumK. Bastuck, J. Fischbach, M. Vogelgesang, J. Treitz, R. Ströder, I. Juhasz-Böss, E.-F. Solomayer R. M. Bohle, S. Lohse, S. Smola (Homburg/Saar/DE)

P 364 HCMV Dense Bodies Induce an Antiviral Cellular EnvironmentI. Penner, M. Dejung, A. Freiwald, F. Butter (Mainz/DE), M. KreutzS. Thomas (Regensburg/DE), C. Zimmermann, B. Plachter (Mainz/DE)

P 365 Replication of IRES-containing viral RNAs supports the translation of IRES-containing cellular mRNAsA. Poshtgohian Madi, A. Penzel, M. Zimmer, S. Friedrich, E. WinklerS.-E. Behrens (Halle a. d. Saale/DE)

P 366 HIV-1 infection and the nonsense-mediated mRNA decay pathwayL. Walotka, F. Hillebrand, N. Diehl, H. Schaal (Düsseldorf/DE)

P 367 Can the replication and transcription activator (RTA) of Kaposi’s sarcoma-associated herpesvirus also act as a transcriptional repressor? K. A. Bussey, H. Todt, M. M. Brinkmann (Braunschweig/DE)

P 368 Herpesviral infection induces a germline-specific transcriptional program mimicking zygotic gene activationS. Walter (Erlangen/DE), E. Wyler, V. Franke, A. Akalin, M. Landthaler (Berlin/DE), A. Ensser F. Full (Erlangen/DE)

P 369 Endogenous retroviral envelope protein(ERVWE1) regulates calcium influx and activates the small conductance Ca2+-activated K+ channelF. Zhu (Wuhan/CN)

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P 370 Contribution of the cellular lipid kinase PI4KA to Hepatitis C virus induced liver pathogenesis.C. S. Tran, C. Schenk, O. Colasanti, P. Mutz, R. Bartenschlager, V. Lohmann (Heidelberg/DE)

P 371 A live-cell imaging approach to track episome dynamics and investigate early events inKSHV latency establishmentT. Günther, M. Hamann, A. Grundhoff (Hamburg/DE)

P 372 The viral chemokine binding protein expressed by varicella zoster virus is spliced and released to the supernatant of infected cellsC. Jürgens (Hanover/DE), V. González-Motos (Strasbourg/FR), S. Krooss, B. Ritter, K. Kropp J. Bohne, A. Viejo-Borbolla, B. B. Kaufer (Hanover/DE)

P 373 Infection of cell lines derived from diffuse large B-cell lymphoma (DLBCL) with the Epstein-Barr virus (EBV) alters the miRNA loading of the Ago2-complexF. Grässer, H. Ayoubian, N. Ludwig (Homburg/Saar/DE), T. Fehlmann (Saarbrücken/DE)J. Menegatti, L. Gröger (Homburg/Saar/DE), E. Anastasiadou, P. Trivedi (Rome/IT)A. Keller (Saarbrücken/DE), E. Meese (Homburg/Saar/DE)

P 374 Transcriptome of rubella virus-infected human induced pluripotent stem cells and derived lineages reveals alteration of developmental signaturesN. C. Bilz, E. Willscher, H. Binder, J. Böhnke, D. Hübner, U. G. Liebert, C. Claus (Leipzig/DE)

P 375 HAdV E2A modulates anti-apoptotic E1B-55K regulation by recruiting the p53 tumorsuppressor proteinM. Stubbe, J. Mai, P. Groitl, S. Schreiner (Neuherberg, Munich/DE)

P 376 Cross-regulation of cyclin A and β-herpesvirus kinases via composite NLS-RXL elementsB. Bogdanow, M. Schmidt (Berlin/DE), E. Ostermann (Hamburg/DE), H. Weisbach, I. Gruska B. Vetter, K. Imami (Berlin/DE), W. Brune (Hamburg/DE), M. Selbach, C. HagemeierL. Wiebusch (Berlin/DE)

P 377 HSV-1 induced transcription termination defects and the immediate early protein ICP22 disrupt genome structure downstream of genesT. Hennig, L. Djakovic (Würzburg/DE), M. Michalski (Cambridge/GB), A. WhisnantF. Erhard (Würzburg/DE), C. Friedel (Munich/DE), L. Dölken (Würzburg/DE)

P 378 Induced protein aggregation and selective autophagy as a viral immune evasion mechanismE. Muscolino, R. Schmitz (Hamburg/DE), S. Loroch (Dortmund/DE), M. RizzatoE. Caragliano (Hamburg/DE), Y.-H. Kim (Cheongju/KR), E. Krause (Hamburg/DE)V. Juranic Lisnic (Rijeka/HR), A. Sickmann (Dortmund/DE), E. OstermannW. Brune (Hamburg/DE)

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P 443 On the way to unravel the role of CrPV E6 in oncogenesisM. Conrady, J. Lim (Tübingen/DE)

Innate ImmunityP 379 Innate immune response to Ebola virusJ. Wildemann, L. Rivière (Langen/DE), T. Hoenen (Greifswald – Isle of Riems/DE)R. König (Langen/DE; La Jolla, CA/US)

P 380 MAPKAP kinases 2 and 3 inhibit formation of intrahepatic myeloid-cell and CD8+ T-cell aggregates and maintain viral replication upon cytomegalovirus infectionC. Ehlting, A. Zimmermann (Düsseldorf/DE), M. Gaestel (Hanover/DE), D. HäussingerJ. G. Bode (Düsseldorf/DE)

P 381 CD47 is a negative regulator of protective immune responses during influenza virus infectionC. Wenzek, A. Westendorf, J. Buer, T. Knuschke (Essen/DE)

Gesellschaft für Virologie e. V.und Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten e. V.

25–28 March 2020 Berlin • Germany

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30th Annual Meeting of the Society for Virology

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P 382 Profiling anti-influenza activities of the pathogen recognition receptor RIG-I: Novel targets for antiviral intervention strategiesG.-D. Panagiotidis, M. Gerlach, F. Weber (Giessen/DE)

P 383 Identification of novel ISGs involved in the antiviral response against influenza A virusE. E. Spieler, S. Harms, S. Stertz, B. G. Hale (Zurich/CH)

P 384 Regulation of Interferon-kappa expression in normal and HPV16-positive keratinocytesK. Klein, C. Habiger, F. Stubenrauch, T. Iftner (Tübingen/DE)

P 385 Integrating at the single cell level viral infection spread and immune response within the human intestinal epitheliumP. Doldan, S. Muenchau, D. Albrecht, M. Stanifer, S. Boulant (Heidelberg/DE)

P 386 Endogenous SERINC5 is modulated by IFN-alpha and antagonized by HIV-1 Nef despite incorporation into virionsV. Passos (Hanover/DE), T. Zillinger (Bonn/DE), N. Casartelli (Paris/FR), S. XuA. Malassa (Hanover/DE), H. Schilling (Bonn/DE), S. Franz (Hanover/DE), K. SutterU. Dittmer (Essen/DE), O. Schwartz (Paris/FR), W. Barchet (Bonn/DE)C. Goffinet (Hanover, Berlin/DE)

P 387 Sex differences in influenza A virus pathogenesis S. Stanelle-Bertram, B. Tuku, J. Sellau, S. Hoenow, H. Lotter (Hamburg/DE)G. Gabriel (Hamburg, Hanover/DE)

P 388 The determinants of innate immune responses against retrovirusesO. Cingöz, N. Bannert (Berlin/DE)

P 389 Puumala orthohantavirus triggers MAVS-dependent innate immune responses in human cellsD. Bourquain, G. Benjamin, C. Bodenstein, S. Schürer, L. Schaade (Berlin/DE)

P 390 An Investigation of Innate Factors Which May Influence Ebola Virus Disease OutcomeJ. Mellors, T. Tipton (Salisbury/GB), S. Armstrong (Liverpool/GB), P. Maes (Leuven/BE)J. Hiscox (Liverpool/GB), M. Carroll (Salisbury/GB)

P 391 Endogenous retroviral LTR12C elements are activated upon HIV-1 infection and potentially regulate the expression of antiviral genes GBP2/GBP5S. Srinivasachar Badarinarayan (Ulm/DE), I. Shcherbakova (Munich/DE)S. Langer (La Jolla, CA/US), F. Kirchhoff (Ulm/DE), G. Schotta (Munich/DE)D. Sauter (Ulm/DE)

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P 392 RNAi response of vector mosquitoes against mosquito-specific viruses in vitroM. Leggewie (Hamburg/DE), V. B. Sreenu (Glasgow/GB), R. A. Hall, J. Hobson-PetersB. McLean (Brisbane/AU), J. Schulze (Hamburg/DE), K. Hermanns, S. Junglen (Berlin/DE)E. Schnettler (Hamburg/DE)

P 393 Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection ofprimary human hepatocytesZ. Zhang, M. Trippler, C. Real, M. Werner, T. Kemper, J. Treckmann, A. Paul, H. BabaG. Gerken, H. Wedemeyer, J. Schlaak, M. Lu, R. Broering (Essen/DE)

P 394 The M35 protein of MCMV antagonizes type I interferon transcription by directly binding to the IFNβ enhancer sequenceH. Schwanke, V. G. Magalhaes, S. Schmelz, J. van den Heuvel, K. Büssow, W. Blankenfeldt M. M. Brinkmann (Braunschweig/DE)

P 395 Association between HCMV UL40 peptide sequence and viremia in lung transplant recipientsS. Hartenberger, H. Vietzen, M. Segura-Wang, E. Puchhammer-Stöckl (Vienna/AT)

P 396 Variants of the immunodominant HCV NS5B2841 epitope presented by HLA-B*27:05impact the function of KIR3DL1+ NK cellsT. Senff, R. Grothmann (Düsseldorf/DE), K. Skibbe (Essen/DE), A. Walker (Düsseldorf/DE)N. Scherbaum, F. Heinemann (Essen/DE), S. I. Khakoo (Southampton/GB)J. Timm (Düsseldorf/DE)

P 397 Insights into Innate Sensing of Prototype Foamy Viruses (PFV)M. Bergez (Langen/DE), J. Weber (Dresden/DE), M. Rieß, J. Seifried (Langen/DE), N. StankeC. Munz (Dresden/DE), V. Hornung (Munich/DE), R. König (La Jolla, CA/US; Langen/DE)D. Lindemann (Dresden/DE)

P 398 USP18 Mediates HIV-1’S Innate Immune Sensing Escape in THP-1 CellsE. Osei Kuffour, A. Ayyappan Jaguva Vasudevan (Düsseldorf/DE), J. HollerB. Kim (Georgia/US), P. A. Lang (Düsseldorf/DE), K. S. Lang (Essen/DE)R. König (Langen/DE), D. Häussinger, C. Münk (Düsseldorf/DE)

P 399 Role of mast cells in cytomegalovirus infectionJ. K. Schmiedeke, A.-K. Hartmann, M. Stassen, N. A. W. Lemmermann (Mainz/DE)

P 400 GBP2 and GBP5 restrict replication of human immunodeficiency, Zika, measles and Influenza A viruses by inhibiting furin-mediated processing of viral envelope proteinsE. Braun, D. Hotter, F. Zech, R. Groß, K. Sparrer, J. Müller (Ulm/DE)M. Winkler (Göttingen/DE), G. Simmons (San Francisco, CA/US)S. Pöhlmann (Göttingen/DE), J. Münch, F. Kirchhoff, D. Sauter (Ulm/DE)

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P 401 Investigation of virus-induced inflammasomes by a novel virus-encoded fluorescent caspase-1 reporterM. H. Christensen, Y. M. Tesfamariam, P. Schumachers, T. Zillinger, F. I. Schmidt (Bonn/DE)

P 402 Human adenoviruses of different species down regulate distinct sets of apoptosisreceptors and the EGFR possibly impacting on diseaseH.-G. Burgert (Coventry/GB; Freiburg/DE), H. England, C. Mayne (Coventry/GB)Z. Ruzsics (Freiburg/DE)

P 403 Establishing staphylococcal and Influenza A viral co-infections of human cellsN. Stelling, S. Surabhi, S. Hammerschmidt, N. Siemens (Greifswald – Isle of Riems/DE)

P 404 Protein A from orange-spotted nervous necrosis virus triggers type I interferon production in fish cell via RIG-I/MDA5-MAVS-IRF3 signal pathwayR. Huang, Q. Zhou, J. Xie (Guangzhou/CN)

P 405 Virus- and interferon alpha-induced transcriptomes of the “microbat” Myotis daubentonii (suborder Yangochiroptera)M. Hölzer (Jena/DE), A. Schoen, J. Wulle (Giessen, Braunschweig, Marburg/DE)M. A. Müller (Moscow/RU; Braunschweig, Berlin/DE), C. Drosten (Braunschweig, Berlin/DE) M. Marz (Jena/DE), F. Weber (Marburg, Braunschweig, Giessen/DE)

P 406 Increased resistance of Zika virus to complement by the uptake of CD55S. Bernklau, B. Schiela, Z. Malekshahi (Innsbruck/AT), N. Thielens (Grenoble/FR)R. Würzner, G. Weiss (Innsbruck/AT), K. Stiasny (Vienna/AT), Z. BankiH. Stoiber (Innsbruck/AT)

P 407 Restriction factors that control hepatitis C virus (HCV) species tropismY. Zhang, R. Brown, A. Kusuma, B. Tegtmeyer (Hanover/DE)V. Kinast (Bochum, Hanover/DE), C. Lauber (Dresden/DE), S. Seitz (Heidelberg/DE)E. Steinmann (Bochum/DE), T. Krey, T. Pietschmann (Hanover/DE)

P 408 Nuclear PYHIN proteins inhibit lentiviral gene expression and are evaded by HIV-1 subtype C strainsM. Bosso, D. Hotter (Ulm/DE), K. L. Jønsson (Aarhus/DK), M. Mayer, S. EngelhartD. Krnavek (Ulm/DE), M. R. Jakobsen (Aarhus/DK), D. Sauter, F. Kirchhoff (Ulm/DE)

P 409 Comparative Structural Analysis of Human, Rhesus, and Rat CytomegalovirusIE1 Proteins by X-ray Crystallography Reveals a Conserved Fold with Similarities to the TRIM Coiled-Coil DomainM. Scherer (Ulm/DE), J. Schweininger (Erlangen/DE), E.-M. Schilling, F. RothemundS. Wörz (Ulm/DE), Y. A. Muller (Erlangen/DE), T. Stamminger (Ulm/DE)

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P 410 Characterization of ATRX as a novel co-regulator of the interferon systemA.-C. Stilp, M. Scherer, T. Stamminger (Ulm/DE)

P 411 Induction of HIV-1 restriction factors upon IFNα subtype treatment in T-cell and macrophage model cell linesH. Sertznig, B. Bleekmann, J. Schuhenn, J. Reich, K. Sutter, U. Dittmer, M. Widera (Essen/DE)

P 412 Identification and characterization of the human cytomegalovirus-encoded interferon antagonist targeting STAT2T. Becker, V. T. K. Le-Trilling (Essen/DE), N. Stern-Ginossar (Rehovot/IL)H. Hengel (Freiburg/DE), M. Trilling (Essen/DE)

P 413 Xenoantigen-dependent complement-mediated neutralization of LCMV glycoprotein pseudotyped VSV in human serumZ. Banki, L. Pipperger, I. Koske, N. Wild, D. Bichler, H. Stoiber, G. Wollmann, J. KimpelD. von Laer (Innsbruck/AT)

P 414 Role of STING in autophagy activation during vaccinia virus infectionN. Vágó (Düsseldorf/DE), H. Khatif (Cologne/DE), A. Jakimovich (London/GB), P. PetzschK. Köhrer, I. Drexler (Düsseldorf/DE), J. Mercer (London/GB), J. Lei (Gainesville, FL/US)

P 415 Quantitative analysis of TRIF cleavage by Hepatitis C and Hepatitis A virus proteases and its impact on innate immunityO. Colasanti, K. Esser-Nobis, J. Traut, O. Grünvogel, V. Lohmann (Heidelberg/DE)

P 416 Human diversity of Killer cell Immunoglobulin-like Receptors (KIRs) and HLA class I molecules, and their impact on Ebola virus disease outcomeT. Wawina-Bokalanga, P. Maes (Leuven/BE), M. Carroll (Porton Down/GB)

P 417 Analysis of NK cells in HIV seropositive individuals with and without CMV co-infectionW. Moskorz, C. Thöns (Düsseldorf/DE), H. Streeck (Essen/DE), J. Timm (Düsseldorf/DE)

P 418 Tracking down viral interference with IRF3 activityJ. D. Wuerth, F. Weber (Giessen/DE)

P 419 Charged-to-alanine scanning analyses of yellow fever virus NS4B protein support a role as interferon antagonistM. Schleif, J. Wieseler, L. Jung, B. Kümmerer (Bonn/DE)

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P 420 The interferon-induced antiviral factor tetherin restricts Nipah virus but not Ebola virus replication in fruit bat cellsM. Hoffmann, I. Nehlmeier, C. Brinkmann (Göttingen/DE), V. KrählingL. Behner (Marburg/DE), A.-S. Moldenhauer (Göttingen/DE), N. Krüger (Hanover/DE)J. Nehls, M. Schindler (Tübingen, Neuherberg/DE), T. Hoenen (Greifswald – Isle of Riems/DE)A. Maisner, S. Becker (Marburg/DE), S. Pöhlmann (Göttingen/DE)

P 421 STING drives DC maturation during MVA infection for the efficient induction of poxviral cytotoxic T-cells in vivoC. Barnowski, G. Ciupka, S. Tao, R. Tao (Düsseldorf/DE), L. Jin (Gainesville, FL/US)I. Drexler (Düsseldorf/DE)

P 422 Directed against the same target: RIG-I mediates the antiviral effect of PKR-derived influenza virus RNAsM. Budt, C. Mache, T. Wolff (Berlin/DE)

P 423 The Human Cytomegalovirus ULb´ Protein UL148A Downregulates the NK Cell-Activating Ligand MICAL. Dassa, E. Seidel, E. Oiknine-Djian, R. Yamin, D. G. Wolf (Jerusalem/IL)H. Hengel (Freiburg/DE), M. Trilling (Essen/DE), O. Mandelboim (Jerusalem/IL)V. T. K. Le-Trilling (Essen/DE)

P 424 Analysis of co-stimulatory molecules on lymphocytes in HCV infectionS. Tewes, A. Walker, J. Timm, C. Thöns (Düsseldorf/DE)

P 425 Salmonella flagellin modulates intrahepatic CD8+ T-cell activation and function by stimulating the TLR5-signal pathway of hepatocytesH. Yan, H. Yan, E. Zhang (Wuhan/CN)

P 426 RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptidesH. Li (Guangzhou/CN)

P 427 Shrimp with knockdown of LvSOCS2, a negative feedback loop regulator of JAK/STAT pathway in Litopenaeus vannamei, exhibit enhanced resistance gainst WSSVS. Wang (Guangzhou/CN)

P 428 Epigenetic modification is regulated by the interaction of influenza A virus nonstructural protein-1 with the de novo DNA methyltransferase DNMT3B and subsequent transport to the cytoplasm for K48-linked polyubiquitinationS. Liu, Z. Li, L. Yong, W. Xueyu, L. Qian, Z. Chengliang, Y. Yuecheng, W. Jun, S. YinglongL. Mengji, Z. Ying (Wuhan/CN)

Qual i tätskontrol le für die molekulare Diagnost ikQual i ty Control for Molecular Diagnost ics

Blutübertragbare Viren MultiparameterdiagnostikZentrales Nervensystem Respiratorische ErkrankungenKongenitale Infektionen Wirkstoffresistenz Tropenkrankheiten / “Emerging Diseases“ Serologie Sexuell übertragbare Infektionen Tx-assoziierte ErkrankungenGastrointestinale Erkrankungen TypisierungImmunschwäche-assoziierte Erkrankungen

SERO

MPP

QCMD – Ihr Partner in der Qualitätssicherung der molekularen Diagnostik

www.qcmd.org

QCMD Head Office Todd Campus, West of Scotland

Science Park, Glasgow, Scotland, UK

Tel: +44 (0) 141 945 6474 Fax: +44 (0) 141 945 5795

93

POSTER SESSION 3

P 429 Early intrahepatic TLR4 activation facilitates HBV persistence through strengthening Kupffer cell mediated T-cell suppressionD. Yang, W. Zhou, J. Luo, Q. Yu, Y. Xie, J. Liu (Wuhan/CN)

P 430 Activation of intrahepatic IFN-alpha/beta signaling at early stage leads to HBV persistence in mice modelW. Jun, S. Zou (Wuhan/CN), Y. Du (Wuhan/CN; Essen/DE), S. Huang, M. Han, Q. Yu, J. LiJ. Liu, X. Zheng (Wuhan/CN), U. Dittmer, M. Lu (Essen/DE), D. Yang, B. Wang (Wuhan/CN)

P 431 Nuclear import of the rabies virus P protein is required for inhibition of RIG-I-like receptor-mediated type I interferon inductionA. A. Hennrich, M. Wachowius, M. Oberhuber, K.-K. Conzelmann (Munich/DE)

P 432 Rat Cytomegalovirus g-chemokine vXCL1 interacts with XCR1+ dendritic cellsJ. C. Madela, A. Bauer, S. Voigt (Berlin/DE)

P 433 Infection of primary fetal endothelial cells with rubella virus induce activation of NF-kB signaling pathwayA. Bauer, P. Rennert, H. Geyer, N. Friedrich, A. Mankertz (Berlin/DE)

Qual i tätskontrol le für die molekulare Diagnost ikQual i ty Control for Molecular Diagnost ics

Blutübertragbare Viren MultiparameterdiagnostikZentrales Nervensystem Respiratorische ErkrankungenKongenitale Infektionen Wirkstoffresistenz Tropenkrankheiten / “Emerging Diseases“ Serologie Sexuell übertragbare Infektionen Tx-assoziierte ErkrankungenGastrointestinale Erkrankungen TypisierungImmunschwäche-assoziierte Erkrankungen

SERO

MPP

QCMD – Ihr Partner in der Qualitätssicherung der molekularen Diagnostik

www.qcmd.org

QCMD Head Office Todd Campus, West of Scotland

Science Park, Glasgow, Scotland, UK

Tel: +44 (0) 141 945 6474 Fax: +44 (0) 141 945 5795

94

POSTER SESSION 3

P 434 The activation of type III interferon pathways in induced pluripotent stem cells and derived embryonic germ layer cellsN. C. Bilz, E. Willscher, H. Binder, J. Böhnke (Leipzig/DE), M. L. StaniferS. Boulant (Heidelberg/DE), G. Frascaroli (Hamburg/DE), U. G. Liebert, C. Claus (Leipzig/DE)

P 435 Murine cytomegalovirus m139 protein regulates interferon induction by interacting with DDX3O. Puhach, E. Ostermann, C. Krisp, H. Schlüter (Hamburg/DE)M. Brinkmann (Braunschweig/DE), W. Brune (Hamburg/DE)

P 436 Absence of cGAS-Mediated Type I IFN Induction in HIV-1-Infected T-CellsJ. Kazmierski (Berlin, Hanover/DE), C. Elsner, A. Ponnurangam (Hanover/DE)T. Zillinger (Bonn/DE), K. Döhner, A. Pohlmann, P. Tegtmeyer, N. Kriedemann, A. DucrouxS. Xu, A. Malassa, U. Kalinke, B. Sodeik (Hanover/DE), W. Barchet (Bonn/DE)C. Goffinet (Hanover, Berlin/DE)

P 437 Dissection of early cellular antiviral responses to HCV infection in adult primary human hepatocytesB. Tegtmeyer, G. Vieyres (Hanover/DE), M. Herrmann (Langen/DE), F. W. R. VondranT. Pietschmann (Hanover/DE), R. J. P. Brown (Hanover, Langen/DE)

P 438 Role of the chromatin-associated proto-oncogene DEK during productive infection with HAdVJ. Mai, S. Masser (Neuherberg, Munich/DE), S. Wells (Cincinnati, OH/US)S. Schreiner (Neuherberg, Munich/DE)

P 439 Apobec3A is a novel restriction factor antagonizing efficient HAdV replicationC. Weiß, L. Göttig, M. Stubbe, S. Hofmann, D. Stadler, U. ProtzerS. Schreiner (Neuherberg, Munich/DE)

P 440 Restriction of herpes simplex virus 1 infection in macrophagesA. Ramos-Nascimento, A. Hinz, T. Koitan (Hanover/DE), R. J. Lebbink (Utrecht/NL)B. Snijder, L. Pelkmans (Zurich/CH), B. Sodeik (Hanover/DE)

P 441 Ebola virus VP35 counteracts PKR to prevent the antiviral effects of stress granule formationK. L. Schierhorn, H. Wilson, R. P. Galao, F. Debeljak, S. J. Neil, C. M. Swanson (London/GB)

P 442 The human cytomegalovirus protein UL35 modulates the type I interferon responseM. Brinkmann, M. Fabits, V. Gonçalves Magalhães, B. Chan (Braunschweig/DE)V. Girault (Munich/DE), E. Elbasani (Hanover/DE), A. Pichlmair (Munich/DE)M. Messerle (Hanover/DE)

95

SPONSORS

We would like to thank the following sponsors for their great support:

Platinum SponsorQIAGEN GmbH

Gold SponsorMSD Sharp & Dohme GmbH

Silver SponsorsAbbott GmbH & Co. KG

Beckman Coulter GmbH

Eurogentec S. A.

FUJIFILM Deutschland, Niederlassung der FUJIFILM Europe GmbH

INSTAND e. V.

Labotect Labor-Technik-Göttingen GmbH

Bronze SponsorsLuminex BV

Takara Bio Europe SAS

Further SponsorsBIOMOL GmbH Caister Academic Press Ltd.Euroimmun AG GeneTex, Inc.InvivoGenSiemens Healthcare Diagnostics GmbH QCMD State at printing.

96

INDUSTRIAL ExHIBITION

The following exhibitors are looking forward to welcoming you at their booth:

Company Booth No.

Abbott GmbH & Co. KG 12

Altona Diagnostics GmbH 5

Analytik Jena AG 6

Beckman Coulter GmbH 18

Becton Dickinson GmbH 26

Bio-Sys GmbH 7

BioLegend GmbH 20

BIOZOL Diagnostica Vertrieb GmbH 3

Biozym Scientific GmbH 14

DiaSorin Deutschland GmbH 23

Eurogentec S. A. 1

Fujirebio Germany GmbH 2

FUJIFILM Deutschland, Niederlassung der FUJIFILM Europe GmbH 16

Hologic Deutschland GmbH 4

INSTAND e. V. 15

INTEGRA Biosciences Deutschland GmbH 19

Labotect Labor-Technik-Göttingen GmbH 10

Luminex BV 13

MACHEREY-NAGEL GmbH & Co. KG 28

MSD Sharp & Dohme GmbH 21

New England BioLabs GmbH 25

Perkin Elmer LAS (Germany) GmbH 17

Sarstedt AG & Co. KG 8

Seegene Germany GmbH 9

Takara Bio Europe SAS 27

QIAGEN GmbH 11

Quidel Germany GmbH 22

Zymo Research Europe GmbH 24

State at printing.

97

FLOOR PLAN

State at printing.

Ground Floor

st1 floorLive

StreamHall 3B

LectureHall 3C

LectureHall 3D(Gallery)

27 26 24

23

22

21

28

Main Entrance

LectureHall 3A (Gallery)

25

19 18

1

2

3

117 9 12

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8 10 13 14 15 16 17

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Entrance

LectureHall 3A

LectureHall 3D Lecture

Hall 3C

Speakers‘ReadyRoom

Registration CateringePoster Terminal 1, 2 and Self Study Terminals

© Heinrich-Heine-University DüsseldorfConference Bags Wardrobe Industrial Exhibition

LiveStreamHall 3B

20

98

MEDIA COOPERATIONS

We would like to give our sincere thanks to the following media partners:

Bundesverband der Hygieneinspektoren e. V.Der Hygieneinspektor

Büro-, Verlags- und TagungsserviceDer Mikrobiologe

Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e. V. Klinische Chemie Mitteilungen

Referenzinstitut für Bioanalytik/Ringversuche (RfB)S. Karger AGIntervirology; Journal of Innate Immunity; Molecular Microbiology and Biotechnology

Springer-Verlag GmbHVirus Genes; European Journal of Clinical Microbiology & Infectious Diseases; Archives of Virology

Trillium GmbH Trillium Diagnostik; Trillium Immunologie

State at printing.

99

GENERAL INFORMATION

AbstractsAll abstracts will be available as a pdf-file on the website at www.virology-meeting.de. Please note that all abstracts are printed as handed-in.

AwardsAll posters will be rated according to scientific basis and visual appearance. There will be awards for the three best posters.

CateringTea, coffee, refreshments and snacks will be provided during the official programme breaks within the exhibition areas (please refer to pages 97). Free lunch boxes will be offered on Thursday and Friday during the industrial symposia.

Certificate of AttendanceCertificates of attendance may be picked up upon leaving the conference at the Check-In.

Education CreditsThe certification of the conference for veterinarians is conducted by the “Medical Chamber of Veterinary” (Bundestierärztekammer, Akademie für tierärztliche Fortbildung).

Credit hours “Medical Chamber of Veterinary”: 20–23 March, 23 hours

GTC

General Terms and ConditionsPlease find all details on our website at www.virology-meeting.de.

InternetA wireless internet access (wifi) is available in the main building.

LanguageThe conference language is English. No simultaneous translation will be provided.

http://www.virology-meeting.de

http://www.virology-meeting.de

SOCIAL PROGRAMME

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Get-Together I Wednesday, 20 MarchA warm welcome in Düsseldorf! Aft er many inter-esti ng talks and presentati ons it is ti me for the fi rst networking evening. We invite you to socialise with your colleagues and other delegates in a pleasant atmosphere with some food and drinks. The Get-Together is included in the registrati on fee.

Date Wednesday, 20 MarchTime 19.00–21.30Locati on Heinrich-Heine-University Building 23.01 I Universitätsstraße 1

Social Evening I Friday, 22 MarchThe social evening will take place on Friday at 20.00 in the Schlösser Quarti er Bohème in the old town of Düsseldorf. Musical highlight of the evening will be the party band “Daniel Ligges & Band” which will certainly set the tone. Enjoy a fantasti c evening and listen to the best hits of the current charts.

Date Friday, 22 MarchTime 20.00–01.30Locati on Schlösser Quarti er Bohème Henkel Saal I Rati nger Straße 25Prize Regular 40 EUR Student* 20 EUR Accompanying person 40 EUR * Confi rmati on of status is required.

Enjoy your time in Dusseldorf

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INDEx OF INVITED SPEAKERS, ABSTRACT AUTHORS AND CHAIR PERSONS

Enjoy your time in Dusseldorf

AAbdelwhab, E. M. P 165 P 166, P 174, P 181, P 202Abere, B. OP 35Aberle, J. OP 03, P 03 P 92, P 242 Aberle, S. OP 03, P 03Abozeid, H. H. P 253Ackermann, J. P 72Adam-Neumaier, S. P 111Adamek, M. P 89Adams, O. P 113, P 20Addo, M. M. SL 04, P 104Adeniji, J. P 297Adesina, O. A. P 302Adewumi, M. P 297Adfeldt, R. P 36Adler, B. P 275Adomeh, D. P 105, P 186Aebischer, A. OP 80Afify, M. P 253, P 256Afridi, S. Q. OP 114Agha, S. B. OP 71Aghebatrafat, A. P 307Ahmed, K. A. P 253, P 256Ahmeti, S. OP 08Aho, V. OP 83, P 222Aire, C. P 105Akalin, A. P 368Akanbi, O. P 153Akarca, U. S. P 43Akas, S. P 214Akgül, B. OP 34, P 353Akhras, S. P 99, P 215 P 243, P 317Akoi Bore, J. P 171Akpede, N. P 186Al-shehabi, H. P 276, P 325Albini, S. P 94Albrecht, D. OP 42, P 385Albrecht, K. P 80Alcami, A. OP 88Alcantara, L. P 22Aldabbagh, S. P 87Alexandrov, A. OP 94Alexandru Caruntu, F. P 43Alhatlani, B. P 126Aliabadi, E. P 14Alkharsah, K. P 223, OP 84Allweiss, L. OP 94Alt, M. OP 06Alter, G. OP 73Altrichter, J. P 244Amann, R. P 235An, R. P 300An, Z. P 24an der Heiden, M. P 98Ananth, S. P 356Anastasiadou, E. P 373Anastasiou, O. P 43, P 83 P 97, P 128

Anderson, D. OP 95, P 192Anderson, F. P 229, P 281Angstwurm, K. OP 29Anhlan, D. P 26, P 196 P 230, P 345Anjorin, A. A. P 299Anspach, J. C. M. P 30Arampatzi, P. OP 61

Armstrong, S. P 390Arndt, D. P 89Arora, P. P 62, P 67Asbach, B. OP 74, OP 102 P 132Asogun, D. P 105, P 186 P 193Aufderhorst, U. OP 06Auste, B. P 191Aydin, I. OP 14Ayoubian, H. P 373Ayyappan Jaguva Vasudevan, A. P 398Azab, W. P 292, P 344Azhar, E. I. P 29

BBaba, H. P 393Babalola, S. R. P 299Babaryka, G. P 200Bach, C. P 250Bächlein, C. P 175, P 195Backovic, M. P 257Badenhorst, M. P 190Bader, M. P 281Badusche, M. OP 69Bahai, A. OP 23Bai, Y. P 300Bailer, S. P 68Balakrishnan, K. P 125 P 130Balkema-Buschmann, A. P 160Banadyga, L. P 358Banas, B. OP 29, P 101Banas, M. P 101Banerjee, S. P 130Banki, Z. OP 21, P 406 P 413Bankwitz, D. OP 23, P 248Bannert, N. P 98, P 276 P 325, P 388Baptista, M. OP 61Barabas, S. OP 11, P 101Barchet, W. P 386, P 436Barnowski, C. P 421Baron, A. L. P 175Bartels, E. SL 04Bartenschlager, R. P 184 P 370Barth, E. P 136Barth, P. P 48

Bartmeyer, B. P 98Bartsch, T. P 86Bartusch, C. P 206Basak, G. W. P 81, P 82Basic, M. P 50Bastuck, K. OP 60, P 363Batzilla, J. P 101Bauer, A. P 432, P 433Bauerfeind, R. P 281Baumann, I. I. P 176Baumann, J. P 273Baumgärtner, W. P 175 P 176, P 195Bayer, L. P 237Bayer, W. OP 19, P 238Baylis, S. P 305Bdeir, N. P 62, P 67Beauclair, G. P 49Becher, P. P 16, P 175 P 195, P 245, P 283Beck, R. OP 114Becker, Ja. P 01Becker, Jü. P 91Becker, N. OP 28, P 183Becker, Sa. P 18Becker, Stephan OP 15 P 100, P 147, P 194 P 201, P 211, P 219 P 226, P 343, P 420 P 46, SL 04Becker, Stephanie P 102Becker, T. P 412Beckert, H. P 02Beer, M. OP 29, OP 50 OP 68, OP 77, OP 80 OP 81, OP 108, P 148 P 157, P 159, P 170 P 172, P 173, P 234 P 262, P 298Behner, L. P 420Behrends, U. P 74Behrendt, P. OP 53, P 179 P 316Behrendt, R. P 294, P 332Behrens, S.-E. P 365Beicht, J. P 273Beierfuß, A. P 251Ben-Mordehai, T. P 220Bender, D. OP 87, P 161 P 317Bendfeldt, H. P 101Benjamin, G. P 389Benner, C. P 262Bergang, V. SL 03Bergant, V. OP 64Bergemann, F. P 294Berger, A. P 93Bergez, M. OP 56, P 397Berisha, L. OP 08Berkó, B. OP 25Bernasconi, V. P 01

Bernhard, A. P 84Bernklau, S. P 406Bertzbach, L. D. P 124Berzow, D. P 51Beyrer, K. P 304Bezencheck, A. P 58, P 60Bhatia, S. P 31Bhusal, C. L. P 199Bi, Y. P 21, P 24Bialy, D. P 281Bichler, D. OP 21, P 413Bieber, T. P 77Biedenkopf, N. P 147Bilinski, J. P 81, P 82Bilz, N. C. P 374, P 434Binder, H. P 374, P 434Binder, M. OP 105, P 131Birk, A. P 91Bisaso, K. P 60Bischof, G. P 249Bischoff, H. P 209Bispo de Filippis, A. M. OP 08, OP 10Blankenfeldt, W. P 394Blaum, F. P 18Blaurock, C. P 165Bleekmann, B. P 128, P 411Bley, H. P 333Bleyer, M. P 200Blockus, S. OP 91Blohm, U. P 174Blümel, J. P 305Bobinger, T. P 152Bochen, F. OP 25Bochud, M. P 210Bock, C.-T. P 98, P 153Bock, T. P 302Bockholt, S. P 169, P 193Boczek, P. P 81, P 82Bode, J. G. P 357, P 380Bodem, J. P 63Bodenhausen, M. P 74Bodenstein, C. P 389Bodmer, B. S. OP 78Boeckh, M. P 85Boeger, C. P 101Boergeling, Y. P 196Boff, L. P 26, P 57Bogdanow, B. P 376Bogner, E. P 36, P 122Bogomolov, P. OP 94Bohle, R. M. OP 33, OP 60 P 363Böhm, M. OP 112, P 58 P 60Böhm, S. P 90, P 115Bohne, J. P 372Böhnke, J. P 374, P 434Böhnke, P. OP 34Bojková, D. P 293, P 359Bokelmann, M. P 308

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Boller, K. P 214Bolte, H. OP 81, P 228Böning, H. OP 84Börgeling, Y. P 230Borgemeister, C. OP 71Borkner, L. OP 05Bornemann, L. P 40Boršová, K. P 191Borst, E. OP 84Boscheinen, J. B. P 250Bosse, J. P 224, P 281 P 352Bosso, M. P 408Bostedt, L. P 213Böttcher, D. P 342Böttcher, S. OP 26, OP 72 P 304Böttcher-Friebertshäuser, E. P 322Boukhallouk, F. P 285Boulant, S. OP 42, OP 63 P 385, P 434Bourquain, D. P 389Bower, H. P 171Bowie, A. IL 09Bradt, V. P 233Brait, N. P 275Brancati, F. OP 110Brandmüller, C. P 296Brandt, J. OP 85Bräsen, J. H. P 83Braun, B. P 265Braun, E. P 400Brech, J. P 04Bredtmann, C. P 80Breitkopf, V. P 156Bremer, B. OP 94, P 97Bremer, V. P 98Brennan, B. P 102Breß, A. P 91Bresk, C. A. P 251Breuer, J. IL 03, P 74Breuer, S. P 109Brey, C. P 41Brinkhoff, A. P 128, P 83Brinkmann, C. P 420Brinkmann, M. IL 08, P 367 P 394, P 435, P 442Britt, W. J. P 59Brochhausen, C. OP 29Brockmann, D. IL 01Brockmeyer, N. OP 30 P 114Brodsky, L. OP 59Broering, R. P 393Brönstrup, M. P 44Bröring, R. P 359Brown, D. OP 08, OP 10Brown, R. OP 82, P 188 P 407Brown, R. J. P. P 437

Brozy, J. P 41Brück, K. P 134Brückner, N. P 281Bruening, J. OP 82Brügger, B. P 353Brune, W. OP 13, P 347 P 351, P 376, P 378, P 435Brunotte, L. P 32, P 48 P 350, SL 03Buch, A. P 49, P 281Büch, J. P 58, P 60Bücher, K. P 266Buchholz, M. P 53Buchholz, S. OP 34Buderus, S. P 87Budt, M. P 422Buer, J. P 238, P 381Buhl, R. P 02Bunz, O. P 68Bürge, S. OP 07Burgert, H.-G. P 402Burkhard, T. R. P 309Busch, C. P 217Busch, J. P 342Büscher, N. P 360Bussey, K. A. P 367Büssow, K. P 394Bütepage, M. P 328Butter, F. OP 86, P 364Bylapudi, G. P 123

CCadar, D. OP 28Cagatay, G. N. P 16Calvignac-Spencer, S. P 307Camacho, R. P 51Canavan, C. P 45Caragliano, E. P 378Carlson, J. P 55Carrington, M. IL 05, P 07Carroll, M. P 07, P 08 P 171, P 390, P 416Carvalho de Sequeira, P. OP 08, OP 10Casartelli, N. P 386Cattaneo, R. OP 59Cavalleri, J. P 190Cebulski, K. P 198Chai, Y. P 24Chan, B. P 442Chang, C. P 300Chang, M. W. P 262Chang, Y. OP 35Charpentier, C. P 51Chaudhry, Z. OP 05Chen, H. P 11Chen, J.-H. OP 83, P 222Chen, Jia. P 21Chen, Jie. SG 06Chen, Z. P 24Cheng, H. P 56

Cheng, S. P 56Chengliang, Z. P 428Chepkorir, E. OP 71Cherpillod, P. OP 03Chiang, C. M. P 310Ching, W. P 224Chittka, D. P 101Christensen, M. H. P 401Christersson-Wiegers, A. P 345Chudy, M. P 167Chukhno, E. P 180Chulanov, V. OP 94Chunchen, W. P 340Cicin-Sain, L. OP 05, OP 39 OP 62Ciesek, S. OP 103, OP 15 OP 94, P 30, P 83, P 86 P 95, P 97, P 128, P 346 P 359 Ciminski, K. P 170, P 172 P 228, P 230, P 262Cingöz, O. P 388Ciupka, G. P 421Ciurkiewicz, M. P 195Claus, C. P 374, P 434Colasanti, O. P 370, P 415Comvalius, A. P 242Connor, J. P 193Conrady, M. P 443Conzelmann, C. P 47Conzelmann, K.-K. OP 101 P 431Coras, R. P 152Cordes, A. OP 12Cordisco, S. OP 110Corman, V. M. OP 72Cornberg, M. OP 22, P 14 P 15, P 43Cornelius, A. P 229Corrales-Aguilar, E. OP 01 P 04Cortese, M. P 184Costa, R. OP 15, P 86 SG 03Couacy-Hymann, E. P 308Couté, Y. P 34, P 360Cramer, P. P 12Cretu, C. P 274Creutznacher, R. P 266Cristea, I. P 349Cucarro, I. P 64Curescu, M. G. P 43Curth, U. OP 84Czech-Sioli, M. OP 104Czechowicz, J. OP 88

DD’Costa, C. P 272da Rocha Matos, A. P 48Dächert, C. OP 105, P 131

Dahlke, C. P 104, SL 04Dammermann, W. P 42Dan, C. P 340Dandri, M. OP 94Dapa, S. OP 47Dassa, L. P 423David, P. P 10, P 37Davison, A. J. P 178de Andrade Krätzig, N. OP 64de Jong, A. OP 02, P 05De La Cruz, N. P 259De Luca, A. P 58, P 60de Swart, R. L. OP 02 OP 110, P 05, P 75, P 242de Vries, L. P 281de Vries, R. D. OP 02 OP 110, P 05, P 75, P 242de Wilde, A. P 66de Witt, M. P 48Debeljak, F. P 441Degrandi, D. P 38Dejung, M. P 364Del Sarto, J. P 22DeLuca, N. P 250Deml, L. OP 11, P 101Deng, F. P 300Deng, Z.-L. P 74Deniz, M. P 184Denner, J. P 325Derua, R. P 312Descamps, D. P 51Deschermeier, C. OP 08 OP 10Desirò, D. P 129Desrosiers, R. C. P 249 P 274, P 277Deutsch, R. OP 63Deutschmann, J. SL 01Devignot, S. P 150, P 309Dhimal, M. P 199Dhingra, A. P 74, P 178Di Guardo, G. P 164Diallo, B. P 171Dichtl, K. P 115Dickow, J. OP 04, P 128Diedrich, S. OP 72, P 304Diehl, N. P 366Dietrich, U. P 239Dietz, A. P 184Dietz, J. P 86Dietzel, E. OP 15, P 46Dijkman, R. OP 45, OP 64Dill, V. P 234Dilthey, A. P 145Ding, S. OP 74Ding, Y. P 56Dinhopl, N. P 139Dirks, M. OP 06Ditschkowski, M. OP 11

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Dittmer, U. OP 04, OP 06 OP 21, OP 41, OP 57 OP 65, OP 94, OP 103 P 10, P 30, P 37, P 48 P 70, P 83, P 128, P 238 P 386, P 411, P 430Dittrich, R. OP 06Divocha, V. P 73Djakovic, L. P 141, P 330 P 377Dobner, J. P 357Dodt, C. P 294Doedt, J. P 273Doellinger, J. P 106Doepke, M. OP 23Doering, M. P 58Döhner, K. OP 15, OP 47 P 208, P 229, P 281 P 349, P 436Dold, L. OP 23, P 248Doldan, P. P 385Dölken, L. OP 61, P 89 P 112, P 141, P 329 P 330, P 377Dolnik, O. OP 15, P 100 P 201, P 219Domingo, A. OP 88Domingues, A. P 249Domingues, P. OP 108Donakonda, S. OP 114Donhauser, N. P 227Donohue, R. C. OP 59Donoso Mantke, O. P 167Döring, M. P 51Döring, T. P 206Dörr, M. P 133Dörrie, J. P 208, P 250Draßner, C. P 208, P 355Drexler, H. OP 14, P 350Drexler, I. P 17, P 414 P 421Drexler, J. F. P 191, P 271Drosten, C. OP 71, OP 72 OP 44, P 189, P 199 P 271, P 405Du, Y. OP 41, P 430du Bois, F. OP 26Duan, X. P 300Dubrau, D. P 209Ducroux, A. P 436Dülfer, J. P 278Duprex, P. P 75Duprex, W. P. OP 91Duraffour, S. P 105, P 186 P 193Dürrwald, R. P 33, P 88Düthorn, A. P 208, P 355Duwe, S. P 33Dzieciatkowski, T. P 81 P 82

EEberle, J. P 51, P 90Ebert, K. P 01Ebert, N. OP 45, P 121Ebinger, A. OP 29Ebner, F. P 184Eckei, L. P 328Edenborough, K. P 308Effantin, G. P 251Egensperger, R. P 90Eggeling, C. OP 17Ehichioya, D. P 186Ehlert, B. P 225Ehlting, C. P 380Ehmen, C. OP 08, OP 10Ehret, R. P 109, P 98Ehrhardt, A. OP 97, OP 98 P 68, P 288, P 295Ehrhardt, C. OP 19, P 345Ehrhardt, M. OP 100Ehrke-Schulz, E. OP 97 OP 98, P 288, P 295Eickhoff, J. P 34Eickmann, M. P 46, SL 04Eiden, M. P 160Eilbrecht, M. P 146Eis-Hübinger, A. M. OP 26 P 87Eisenberger, U. P 72Eissmann, K. OP 32Ejuan, Z. P 09Ekanem, A. P 186Ekman, A. P 222el Khady, M. P 173El-Kafrawy, S. A. P 29el-Sawah, A. P 173Elbasani, E. P 442Eléouët, J.-F. OP 91Eletto, D. OP 108Elgner, F. OP 87, P 50, P 99 P 161, P 264, P 267, P 317Eller, M. OP 73Ellerbrok, H. OP 07, P 28Elling, R. OP 26Elling, U. P 309Elliott, R. P 102Ellström, P. P 204Elsner, C. P 436Elvstam, O. P 60Elzayat, M. T. OP 44Emmerich, P. OP 08, OP 10Empting, M. P 64Enders, M. P 65, P 93Engelhart, S. P 408Engels, R. P 71England, H. P 402Engleitner, T. OP 64Ennker, K. S. C. OP 09Ensser, A. P 41, P 152 P 249, P 354, P 368Epple, M. P 238

Erck, C. P 198Erhard, F. OP 61, P 112 P 141, P 330, P 377Erhardt, A. P 43Erkelenz, S. P 38Erl, M. P 151Errath, M. OP 29Eschbaumer, M. P 234Eschke, M. P 342Eshetu, A. P 98Essbauer, S. P 244Esser, S. OP 73, P 40Esser-Nobis, K. P 415Esumeh, R. P 186Ewer, K. P 07

FFabits, M. P 442Fackler, O. T. P 356Falcone, V. OP 01Faleye, T. P 297Falk, J. P 108Falkenhagen, A. P 96, P 155Famurewa, O. P 302Fan, Z. P 300Fang, Y. P 300Fang Lim, X. P 192Fast, L. P 285Fathi, A. SL 04Fatola, O. I. P 166Feger, T. P 235Fehling, S. K. P 225Fehlmann, T. P 373Feichtinger, S. P 327Feil, F. P 304Feld, P. OP 92Felder, E. OP 102Ferguson, L. P 123Ferling, H. P 89Ferre, S. P 360Ferreirós, N. SL 01Festag, M. P 06Feuerherd, M. P 42Fiebig, U. P 325Fiedler, A. H. OP 78Fiedler, M. P 12Fiedler, M. P 72Fingas, F. P 107Finke, S. OP 70, P 182Fischbach, J. OP 33, OP 60 OP 100, P 363Fischer, Cari. P 284Fischer, Carl. P 197Fischer, N. OP 104, P 52 P 89, P 104, P 175Fischer, S. P 294Flatz, L. OP 46Fleckenstein, B. OP 31Fleischmann, M. OP 102Flomm, F. P 224Florin, L. P 285

Flosbach, M. P 163Fontanay, S. P 45Forth, L. OP 29Fortugno, P. OP 110Fraaij, P. P 05Francois, S. OP 57Franke, V. P 368Franz, S. OP 18, OP 47 P 386Franzke, K. P 102Frascaroli, G. P 351, P 434Frauenstein, A. OP 82Freitag, K. P 02Freiwald, A. OP 86, P 364Frericks, N. P 95, P 128Freund, C. P 318Fricke, T. P 274, P 277Friebus-Kardash, J. P 72Friedel, C. P 377Friedrich, A. P 221Friedrich, Nic. P 433Friedrich, Nik. P 246Friedrich, S. P 365Friesland, M. OP 53, OP 91 P 179Frishman, D. OP 114Fritzen, A. P 285Fröhlich, J. OP 36Fuchs, A. OP 112Fuchs, Ja. OP 19, P 240 P 241Fuchs, Jo. OP 67Fuchs, K. OP 29Fuchs, W. P 55Full, F. P 354, P 368Funk, C. P 68Fux, R. P 23, P 89, SL 04

GG. A., A.-A. P 256Gableske, S. OP 58Gabriel, G. OP 78, P 331 P 387Gack, M. U. OP 58Gad, H. H. P 01Gadalla, M. R. P 318Gaertner, J. OP 11Gaestel, M. P 380Galao, R. P. P 441Ganzenmueller, T. P 74 P 178Gao, F. P 24Gao, G. F. P 21, P 24 P 103, P 231Gao, J. P 288García-Sastre, A. P 170 P 262Gärtner, S. P 62, P 180Gartner, S. P 67Gast, M. P 207Gautam, I. P 199

104


Beckman Coulter GmbHEuropark Fichtenhain B13 D-47807 KrefeldTel: 02151 33 35, E-Mail: [email protected]: beckmancoulter.com

CytoFLEX S Flow CytometerBenchtop Cytometry without Compromises for Special Applications

DuraClone IMBenchtop Cytometry without Compromises Reduce hands-on time, waste and rework, adopt pre-cocktailed Duraclone IM Panels

The CytoFLEX S Flow Cytometer series is an expansion of the CytoFLEX Platform. The CytoFLEX Flow Cytometer offers three laser options, 488 nm, 638 nm, and 405 nm. The CytoFLEX S Flow Cytometer platform expands your research possibilities, with a fourth laser option, multiple confi gurations and unique fi lter sets for your science. CytoFLEX S Systems are available in preset confi gurations with up to four lasers, including 561 nm, 375 nm or lasers in the original palette and up to 13 channels for fl uorescence detection.

Make life easier with pre-cocktailed DuraClone IM Panels. Eliminate errors due to manual cocktail preparation with these ready-to-use, unitized, dry format panels. Dry DuraClone cocktails deliver improved stability compared with liquid cocktails and are room temperature stable, thus eliminating the need to manage varying expiration dates and revalidations among single color liquid reagents. Ready-to-Use DuraClone IM panels are the natural choice for clinical research studies.

www.beckman.com/coulter-fl ow-cytometry/duraclone-im

www.beckman.com/coulter-fl ow-cytometry/instruments/fl ow-cytometers/cytofl ex-s

DuraClone IM PanelsAvailable in convenient 25 test package. Each package includes three complete compensation kits with single color set of compensation reagents, containing lot-matched tubes for tandem dyes, specifi c for each panel.



package. Each package includes three complete compensation kits with single color set of compensation reagents, containing lot-matched tubes for tandem dyes,

Geffers, R. OP 106, P 339Gehring, T. P 60Geijtenbeek, T. B. OP 110Geisbert, T. OP 75Gellhorn Serra, M. P 194Gelman, R. S. P 251Gerke, C. OP 24Gerken, G. P 393Gerlach, M. P 382Gerlich, W. P 61Gerold, G. OP 15, OP 18 OP 82, P 163, P 335Gerrer, K. P 74Gessner, A. OP 29Geyer, H. P 433Geyeregger, R. P 78Ghanem, A. OP 101Giebel, B. OP 06Giese, S. OP 29, P 228Giesow, K. P 138, P 286Ginkel, C. OP 23Girault, V. P 442Gischke, M. P 165, P 166 P 174, P 202Gladilin, E. OP 105Glatter, T. P 343Glebe, D. P 61Glitscher, M. P 162, P 215 P 321Globig, A. OP 68Glynn, J. P 171Godeke, G.-J. P 168Goelz, R. OP 113Goffinet, C. OP 18, OP 47 P 188, P 335, P 386, P 436Gogrefe, N. OP 51, P 116Goller, K. P 80Gonçalves Magalhães, V. P 442González-Hernández, M. P 290González-Motos, V. P 372Göppert, N. OP 01Goretzko, J. P 32Gorka, M. OP 77, P 170 P 172Gorriz-Martin, L. P 175Görzer, I. P 275Göttig, L. P 439Göttlicher, T. OP 31Götz, K. M. OP 92Graaf, A. P 204, P 298Graf, N. OP 100Graham, B. S. Op 44Gramberg, T. OP 32, P 332 SL 01Grashoff, M. P 198Graßmann, V. OP 74Grass, S. OP 11Grässer, F. P 329, P 373

Greco, T. P 349Grethe, C. OP 91, P 339Greune, L. P 230Grewer, A. P 200Gries, K. P 87Grikscheit, K. P 211Groenke, N. P 254Gröger, L. P 373Groitl, P. OP 54, OP 107 P 348, P 375Gromke, T. OP 11Groneberg, D. A. P 199Groß, R. P 47, P 184 P 265, P 400Grosche, L. P 208, P 355Groschup, M. H. P 160Groseth, A. P 213, P 358Großkopf, A. P 249, P 272 P 274, P 277, P 354Gross, S. P 250Grossegesse, M. P 106Grothe, S. P 230Grothmann, R. P 396Grüll, H. P 239Grundhoff, A. OP 36 OP 104, P 52, P 89 P 352, P 371Grunert, H.-P. P 61Grünewald, K. P 220, P 224 P 352Grünvogel, O. P 415Grunwald, T. OP 96, P 53 P 237Grünweller, A. P 39, P 311Gruska, I. P 376, SL 01Grüttner, C. OP 89, P 320Grützke, J. P 96Grützner, N. P 80Guan, W. P 192Guardado-Calvo, P. OP 80Guenther, S. P 217Guertler, L. P 51Guldan, H. OP 11Gümpel, J. P 237Gundlach, S. P 104Gunesch, A.-P. P 44Günl, F. P 350Günther, S. C. P 258Günther, S. OP 20, OP 51 P 105, P 116, P 169 P 186, P 193Günther, T. OP 36, OP 104 P 352, P 371Gunzer, M. P 40Guo, C. OP 42Guo, R. P 300Gürel, S. P 43Gurtner, C. P 80Güthoff, W. P 61Guthrie, A. P 190

HHaag, R. P 31Haagmans, B. L. SL 04Haase, K. OP 114Haberger, V. P 267Habermann, D. P 15, P 19 P 127Habicht, A. P 101Habierski, A. P 164Habiger, C. P 384Haddad, Y. OP 101Haedicke-Jarboui, J. P 27Haefeli, W. E. OP 94Hage, E. P 178Häge, S. P 212, P 218Hägele, S. P 185Hagemeier, C. P 143, P 376Hahn, A. P 200, P 249 P 272, P 274, P 277, P 354Hahn, F. P 34, P 360Haid, S. OP 91, OP 106 P 339Hainmann, I. P 87Hakanen, S. OP 83, P 222Hale, B. OP 108, P 262 P 383Halenius, A. OP 24Halili, B. OP 08Hall, R. A. P 392Hall, Y. P 07, P 08, P 171Halwe, S. P 201, SL 04Hamann, M. P 294, P 371Hammerschmidt, S. P 403Hamprecht, K. OP 113 P 65, P 93Han, M. OP 41, P 430Han, X. P 318Hansen, G. P 339Hao, Y. P 140Harbig, A. P 322Harder, T. OP 68, P 148 P 298Hardt, M. P 324Hardtke, S. P 43Hareiter, J. P 06Harms, D. P 153Harms, M. P 184, P 265 P 291Harms, S. P 383Hartenberger, S. P 395Hartinger, T. P 246, P 255Härtle, S. P 124Hartmann, A.-K. P 399Hartmann, A. P 152Hartmann, E. P 281Hartmann, L. P 266Hartmann, R. K. P 311Hartmann, R. P 01Harzer, M. P 107Hasenberg, M. P 208Haslwanter, D. OP 03

Hassan, K. E. P 148, P 173Hauber, J. IL 13Hauser, Al. P 246, P 251 P 255Hauser, An. P 98Häussinger, D. P 125, P 130 P 336, P 357, P 380, P 398Hayn, M. P 184Haynes, B. F. P 251He, Y. P 21He, Z. P 341Heber, N. OP 63Hecht, L. P 105Heenemann, K. P 107 P 342Heidenreich, D. OP 11Heilingloh, C. S. P 208Heilmann, R. P 342Heim, A. OP 12Hein-Fuchs, N. P 312, P 313Heindl, R. P 322Heinecke, V. OP 19Heinemann, F. P 15, P 396Heinemann, S. OP 98Heinrichs, S. P 359Heinz, F. X. OP 03, OP 79 P 92, P 03, P 233Heitmann, A. OP 69, P 102 P 183Helfer, M. P 46Hellert, J. OP 80Hellmich, M. OP 30, P 114Helms, M. OP 69Helmy, M. A. P 253, P 256Hengel, H. OP 01, OP 24 P 04, P 11, P 12 P 412, P 423Hennig, T. OP 61, P 330 P 377Henning, M. OP 60Henning-Nagel, C. OP 88Hennrich, A. A. P 431Henß, L. P 39Herden, C. OP 29, P 159Herker, E. OP 89, P 320 P 333, P 334Hermanns, K. P 189, P 392Herold, S. OP 66, P 76Herppich, S. OP 62Herrlein, M.-L. P 317Herrler, G. P 271, P 279 P 280, P 283Herrmann, Al. P 332, SL 01Herrmann, An. P 31Herrmann, M. P 133, P 437Hertel, B. OP 15Hertz, E. P. T. P 147Herzog, S. M. P 152Heß, R. OP 19Hesse, A.-M. P 360Hesterkamp, T. SL 04

105


Beckman Coulter GmbHEuropark Fichtenhain B13 D-47807 KrefeldTel: 02151 33 35, E-Mail: [email protected]: beckmancoulter.com

CytoFLEX S Flow CytometerBenchtop Cytometry without Compromises for Special Applications

DuraClone IMBenchtop Cytometry without Compromises Reduce hands-on time, waste and rework, adopt pre-cocktailed Duraclone IM Panels

The CytoFLEX S Flow Cytometer series is an expansion of the CytoFLEX Platform. The CytoFLEX Flow Cytometer offers three laser options, 488 nm, 638 nm, and 405 nm. The CytoFLEX S Flow Cytometer platform expands your research possibilities, with a fourth laser option, multiple confi gurations and unique fi lter sets for your science. CytoFLEX S Systems are available in preset confi gurations with up to four lasers, including 561 nm, 375 nm or lasers in the original palette and up to 13 channels for fl uorescence detection.

Make life easier with pre-cocktailed DuraClone IM Panels. Eliminate errors due to manual cocktail preparation with these ready-to-use, unitized, dry format panels. Dry DuraClone cocktails deliver improved stability compared with liquid cocktails and are room temperature stable, thus eliminating the need to manage varying expiration dates and revalidations among single color liquid reagents. Ready-to-Use DuraClone IM panels are the natural choice for clinical research studies.


www.beckman.com/coulter-fl ow-cytometry/instruments/fl ow-cytometers/cytofl ex-s




package. Each package includes three complete compensation kits with single color set of compensation reagents, containing lot-matched tubes for tandem dyes,

106


Heym, S. P 227Hickford-Martinez, A. P 281, P 349Hielscher, T. OP 63Hildt, E. OP 87, P 50, P 99 P 161, P 162, P 214 P 215, P 243, P 263 P 264, P 267, P 268 P 317, P 321, P 362Hilgendorf, I. OP 11Hilgenfeld, R. P 66, P 337Hillebrand, F. P 366, P 38Hilpert, A. P 152Himmelsbach, K. P 162 P 317, P 321Hinz, A. P 440Hinzmann, J. P 105, P 186Hippenstiel, S. P 48Hirth, D. OP 45Hiscox, J. P 390Hobson-Peters, J. P 392Hochdorfer, D. P 285Hocke, A. P 48Hoeben, R. C. P 281Hoelper, J. E. OP 109Hoenen, T. OP 43, OP 85 P 379, P 420Hoenow, S. P 387Höfer, C. T. P 261Hofer, T. P 251Hoffmann, C. P 169Hoffmann, D. P 70Hoffmann, Da. P 127, P 15 P 19Hoffmann, Di. OP 114Hoffmann, Do. OP 29 OP 50, OP 77, P 157, P 159 P 170, P 172, P 174, P 262Hoffmann, H. H. OP 45Hoffmann, K. P 04, P 12Hoffmann, M. OP 16 OP 44, P 67, P 84, P 270 P 271, P 284, P 290, P 420Hofmann, H. P 325Hofmann, J. OP 26, OP 72 P 227Hofmann, S. OP 54 OP 107, P 348, P 439Hohn, O. P 276Höhne, M. P 302Holleczek, B. OP 25Holler, J. P 398Holm, T. P 217Hölper, J. E. P 220Holtappels, R. P 02Holter, W. P 41Höltig, D. P 195Hölzer, M. P 129, P 135 P 405Holzerland, J. P 358Holzhauser, T. P 99Homa, G. OP 103

Hong, K. P 140Hoogeveen, R. C. P 15Hoornweg, T. P 168Höper, D. OP 29Hopfensperger, K. OP 37Horner, V. OP 01Hörnich, B. P 272, P 277Hornung, V. P 397Horsch, D. P 212Hotter, D. P 400, P 408Hou, J. P 09Hrincius, E. R. P 345Hu, B. P 261Hu, Z. P 300Huang, H. P 69Huang, J. P 104Huang, R. P 404Huang, S. OP 41, P 430Hubel, P. OP 64, SL 03Hübner, A. P 55Hübner, D. P 374Hudson, J. P 08Huenig, T. OP 11, P 101Hufbauer, M. OP 34, P 353Hufnagel, M. OP 26Hugo, C. P 101Hühn, J. OP 62Hundsdörfer, P. OP 93Hunszinger, V. P 219Hunziker, A. P 269Hurdiss, D. P 278Hutter, S. P 90Hutterer, C. P 34Hüttl, S. P 270Huttner, H. B. P 152Huzly, D. P 87

IIbrahim, B. P 129, P 135Ickler, J. OP 57Iftner, T. P 118, P 235 P 27, P 310, P 384Ighodalo, Y. OP 20, P 105 P 186Ihekweazu, C. P 153Imami, K. P 376Incardona, F. P 58, P 60Indenbirken, D. P 89, P 104 P 347Irrgang, P. P 240, P 241Isken, O. P 119Issmail, L. P 53Ivanov, K. P 123Iyiade, O. P. P 299

JJacobsen, H. P 331Jäger, C. P 53Jäger, J. P 322Jaguva Vasudevan, A. A. P 125Jakimovich, A. P 414

Jakob, V. P 64Jakobsen, M. R. P 408Jakupi, X. OP 08Jang, H. P 247Jang, J. P 247Jang, K. P 184Janowski, J. P 350Jansen, S. OP 69, P 102 P 183Janson, D. OP 11Janssen, M. OP 92Janssens, V. P 312Jantsch, J. OP 29Jany, S. P 23, P 187Japhet, M. O. P 302Järhult, J. P 204Jarmer, J. P 233Jaschinski, F. P 46Jastrow, H. P 208Jeney, C. P 262, P 293Jeninga, M. P 227Jensen, B. OP 112, P 51Jeske, K. P 157Jesse, S. T. P 176Ji, X. P 140Jiang, B. OP 87, P 214 P 215, P 263, P 362Jiang, H. P 24Jiang, R.-D. P 192Jiang, S. IL 12, P 56Jilg, W. OP 29, P 151Jin, L. P 421Jizheng, C. P 341Jo, W. P 164, P 176Joas, S. P 184Joecks, S. OP 82Johne, R. P 96, P 151, P 155Jovanovic, L. P 58Juhasz-Böss, I. OP 33 OP 60, P 363Jun, Wa. P 428Jun, Wu P 430Jung, K. P 164, P 176Jung, L. P 419Junglen, S. OP 71, P 189 P 199, P 392Jungnickl, D. P 152, P 354Juozapaitis, M. OP 77Juranic Lisnic, V. P 378Jürgens, C. P 372Jürges, C. OP 61, P 112 P 141Jønsson, K. L. P 408

KKabuuka, T. P 55Kächele, M. P 244, P 42

Kaderali, L. OP 82, P 131 P 339Kadzioch, N. P. P 207Kagan, K.-O. P 65

Kaiser, R. OP 09, OP 112 P 51, P 58, P 60, P 87Kaiser, T. P 10Kaiserling, R.-L. OP 04Kaitao, Z. P 341Kalinke, U. P 436Kalodimou, G. P 187Kalser, J. P 275Kalusche, S. P 239Kammel, M. P 61Kampmann, M. P 335Karakus, U. P 262Karger, A. P 124Karl, N. P 123Karrer, U. P 233Kasmapour, B. OP 39Kästner, R. P 90Kaufer, B. B. P 124Kaufmann, C. OP 102Kaufmann, S. V. P 284Kaul, A. P 84, P 110, P 178 P 200Kayser, M. P 136Kazmierski, J. P 436Keeren, K. P 304Kefalakes, H. P 15Kehle, J. P 91Kehlenbach, R. P 229Kehrer, T. P 346Keil, Gu. P 138, P 286Keil, Gü. P 55Keitel-Anselmino, V. OP 112, P 15Keller, A. P 373Keller, L. P 34, P 360Kemper, T. OP 90, P 393Kemter, K. P 244Kennedy, J. P 195Keppler, O. T. P 291, P 90Kernbichler, S. P 78Khakoo, S. I. P 396Khatif, H. P 414Khera, T. OP 23Kiener, R. OP 102, P 85 P 101Kießling, M. SL 01Kim, B. P 398Kim, J. OP 73Kim, Se. P 247Kim, So. P 247Kim, Y.-J. OP 33Kim, Y.-H. P 378Kimpel, J. P 237, P 251 P 413Kinast, V. P 190, P 316 P 407Kirchhoff, F. OP 37, OP 58, P 291, P 391 P 400, P 408Kirchner, M. P 329Kirsch, P. P 64Kirui, J. OP 15, OP 18

107


Klar, R. P 46Klebl, B. P 34Klein, F. OP 23, P 239 P 248, P 291Klein, K. P 384Klein, Se. OP 22Klein, St. OP 11Kleine-Weber, H. OP 16 OP 44Kleinschmidt, M. P 53Klemens, O. P 209Klempa, B. P 191Klenerman, P. IL 06Klenk, H.-D. P 273Kleusberg, A. P 91Kley, N. P 160Kleymann, G. OP 96Klintworth, A. OP 15Kloke, L. OP 07Klupp, B. G. OP 109, P 220 P 257Klüver, M. P 46, P 343Knebel-Mörsdorf, D. P 259 P 77, P 260Knegendorf, L. OP 53 P 179Knerr-Rupp, K. OP 33 OP 100Knipe, D. M. P 250Knolle, P. P 06Knolle, P. A. OP 64Knuschke, T. P 238, P 381Ko, C. OP 107Koban, R. OP 07, P 28Kobbe, G. OP 11, P 113Koblischke, M. P 03Koch, K. P 239Koch, M. OP 11, P 101Koch, S. OP 49, OP 84 P 223Koch, T. SL 04Kochs, G. OP 55, OP 64 OP 67Koehler, A. P 343Koenig, M. P 162Koenig, R. OP 56Koepke, L. OP 58Koeppel, K. P 190Koestler, J. P 101Kohmer, N. P 93Köhrer, K. P 414Kohrt, S. P 314Koitan, T. P 440Kolb, P. OP 01, P 11Kolesnikova, L. OP 81 P 219, P 343Kollenda, S. P 238Kolyvushko, O. P 292Kondakci, M. OP 11Köndgen, S. P 191König, P. P 327

König, R. P 312, P 313 P 379, P 397, P 398Koopmans, M. OP 02, P 05Kopicki, J.-D. P 217Kopp, A. P 199Koppe, U. P 58Köppel, M. P 115Kordyukova, L. P 318Korencak, M. P 359, P 40Korn, K. OP 26, P 93, P 152Korpys, Y. P 278Kortenbusch, M. P 93Korth, J. P 83, P 128Kosinska, A. P 06, P 244Koske, I. P 413Koskei, E. OP 71Kosulin, K. P 78Köthe, S. OP 68Kou, C. P 300Koup, R. IL 07Kracht, M. P 343, SL 05Kraemer, B. P 101Kraft, A. OP 22, P 14, P 15Krähling, V. P 420, SL 04Krämer, N. OP 86Krammer, T. OP 61Kraner, M. P 208Kratzel, A. OP 45Kraus, E. P 52Krause, E. P 378Krause, J. OP 96Krauter, S. OP 86Krautkrämer, E. P 185Krautwurst, Sa. P 135Krautwurst, Se. P 142Krawczyk, A. OP 06, P 208Kreher, P. P 308Kreil, S. OP 11Kreuter, A. OP 30, P 114Kreutz, M. P 364Krey, T. OP 15, OP 84 P 223, P 248, P 407Kribben, A. P 72, P 83 P 128Kriedemann, N. P 436Krieg, S. P 328Krischuns, T. P 26, P 350Krismer, M. P 251Krisp, C. P 435Krnavek, D. P 408Kröger, A. OP 38, P 198Krol, M. P 81, P 82Krooss, S. P 372Kropff, B. P 59Kropp, K. OP 88, P 372Krueger, B. P 101Krüger, D. H. P 191Krüger, F. P 47, P 184 P 265Krüger, N. P 270, P 271 P 420Kruppa, J. P 164

Kruse, T. P 147Kuch, U. P 199Kuge, C. P 162Kühn, L. I. P 335Kühne, C. P 42Kuhnhenn, L. P 214Kühnl, A. P 32Kuiken, T. OP 110, P 164Kummer, M. P 208Kümmerer, B. P 419Kunec, D. P 254Kunz, I. P 275Kunz, S. P 163Künzig, F. P 141Kupke, A. P 194, SL 04Kürten, S. P 152Kurth, A. P 308Kusov, Y. P 66Kusuma, A. P 407Küttten, J. OP 25Kutzner, J. P 325Kuznetsova, I. OP 66, P 76

LLacher, P. P 04Lachmann, L. OP 28Lagadec, F. P 229Lai, K.-Y. OP 14Laib Sampaio, K. P 71Laksono, B. OP 110, P 05Lam, T. OP 07Lamkiewicz, K. P 135, P 136Lamp, B. P 139Lander, A. P 308Landthaler, M. P 329 P 368Lang, K. P 238, P 359 P 398Lang, P. A. P 398Lange, C. P 161Lange, M. OP 61Lange-Grünweller, K. P 311Langenmayer, M. P 111 P 89Langer, K. P 230Langer, S. P 391Langsch, P. P 63Lanko, K. P 66Lapuente, D. OP 19, OP 76 P 240, P 241Larabell, C. OP 83, P 222Lassen, S. OP 89, P 320Lasswitz, L. OP 18, P 335Lau, S. SL 05Lauber, C. P 339, P 407Laue, M. OP 92Lauer, G. OP 40, P 15Lauterbach-Rivière, L. OP 56Lavrachenko, L. P 191Lawitschka, A. P 78Lazar, K. OP 113

Le-Trilling, V. T. K. SG 02 P 04, P 146, P 412, P 423Lebbink, R. J. OP 13, P 281 P 440Lee, E. P 247Lee, N. OP 35Leendertz, F. H. P 307Leggewie, M. OP 69, P 102 P 183, P 392Legrand, P. OP 84Lehmann, F. P 239, P 61Lehmann, M. OP 99Lehmann, M. H. P 296Lehmann, P. OP 94Lehmann, U. P 83Lehner, M. P 41Lehr, T. OP 92Lehrer, A. OP 75Lei, Jia. P 337Lei, Ji. P 414Leibbrandt, A. P 309Leidel, S. P 350Lemmermann, N. A. OP 102, P 02, P 18, P 399Lengauer, T. P 58, P 60Lenk, M. OP 108Lenman, A. P 335Lennartz, S. P 58, P 60Leßmann, H. P 298Less, A. P 104Leyssen, P. P 66Li, B. P 192Li, D. P 56Li, H. P 426Li, J. OP 41, P 430Li, Mingl. P 56Li, Mingx. P 21Li, R. P 204Li, S.-Y. P 192Li, T. P 70Li, X. P 56Li, Y. P 70Li, Ya. P 103Li, Z. P 428Liang, B. P 21Liang, H. P 56Liang, J. P 300Liang, M. P 24Liang, S. P 70Liao, H.-X. P 251Lieber, D. P 285Lieberman, M. OP 75Liebert, U. G. OP 111 P 374, P 434Liedke, K. OP 19Liese, S. P 31Lim, J. P 443Limburg, H. P 322Lin, D. P 66Lin, Y. OP 90, P 323Lindel, F. P 294Lindemann, D. P 294, P 397

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Lindemann, M. OP 11 P 101Lindig, V. P 61Lindner, K. P 120Lindner, N. OP 96Lingemann, M. P 289Linker, R. OP 29Linne, U. P 343, SL 05Linxweiler, M. OP 25Lion, T. P 78Lippok, B. P 328Lippold, S. P 184, P 265Littwitz-Salomon, E. OP 41Liu, D. P 21Liu, F. P 344Liu, Ha. P 21Liu, Ho. P 66Liu, J. OP 41, P 09, P 69 P 429, P 430, SG 07Liu, S. P 323, P 428Liu, W. P 56Liu, W. J. P 24Liu, X.-L. P 192Lohmann, V. OP 105, P 346 P 370, P 415Lohse, A. SL 04Lohse, S. OP 25, OP 60 OP 92, P 363Lopez de Blas, I. P 278Loroch, S. P 347, P 378Lotfi, R. OP 06Lotter, H. P 387Lozach, P.-Y. P 335Lu, F. P 137Lu, M. OP 41, OP 90, P 09 P 393, P 430, SG 04Lu, M. P 323Lübke, N. OP 09, OP 112Lücking, H. P 152Ludlow, M. P 164, P 176Ludwig, K. P 31Ludwig, N. P 373Ludwig, S. P 350Ludwig, S. P 26, P 32, P 48 P 196, P 22, P 230, P 345Luelf-Averhoff, A. P 111Lugner, T. P 101Lühken, R. OP 28, OP 69 P 183Lukashev, A. N. P 191Lukassen, S. OP 39Lundkvist, Å. P 204Luo, J. P 429Luo, T. P 300Lüscher, B. P 328Lütgehetmann, M. P 104Lüth, S. P 42, P 43Ly, M. L. SL 04Lycke, N. P 01

MMa, L. P 56, P 140

Ma, Q. P 66Ma, T. P 24Ma, W. P 170Ma-Lauer, Y. P 337Maaske, A. OP 19Maaz, J. P 348Macdonald, A. P 278Mach, M. P 59Machado, A. P 22Mache, C. P 422Madela, J. C. P 432Madhugiri, R. P 123, P 135Maes, P. P 390, P 416Magalhaes, V. G. P 394Magnus, C. OP 108Mai, J. P 348, P 375, P 438Maier, C. OP 19, P 24 P 241Maier, H. P 352Maini, M. P 15Maintz, L. P 77Maisner, A. OP 02, P 420Majer, C. P 313Majewski, S. P 353Makarov, V. P 36Malafa, S. OP 03, P 03 P 233Malassa, A. P 386, P 436Malekshahi, Z. P 406Mallagaray, A. P 266Malyshkina, A. OP 65Mandelboim, O. P 423Mankertz, A. P 433Manley, S. OP 17Manns, M. OP 15, OP 22 P 14, P 43P 44, P 86Manokaran, V. P 17Mäntylä, E. P 222Mar, K. B. OP 45Marcotte, H. P 239Mariggiò, G. OP 49Markiefka, B. P 353Marklewitz, M. OP 71 P 189Marovich, M. OP 73Marschall, M. P 34, P 212 P 218, P 314, P 360Marthaler, A. OP 33Martin, K. P 117Martin, M. P 07Martín, R. OP 88Martina, B. E. P 242Martinez, J. P 45Martins, M. P 249Marx, B. P 87, P 353Marz, M. P 129, P 136 P 142, P 405Mas Marques, A. P 302Masser, S. P 348, P 438Matheron, S. P 51Mathias, E. P 22Matrosovich, M. P 273

Matrosovich, T. P 273Mattola, S. OP 83, P 222Mätz-Rensing, K. P 178 P 200Maurer, W. P 284Maxeiner, J. P 02Mayer, B. P 184Mayer, M. P 408Mayne, C. P 402Maywald, M. P 145Mazzariol, S. P 164Mbui, F. OP 05McCulloch, E. P 167McElrath, J. OP 74McHardy, A. OP 23, P 74McKeating, J. P 348McLean, B. P 392Mecate-Zambrano, A. P 196, P 230Medialdea-Carrera, R. OP 08, OP 10Medina, L. OP 75Medits, I. OP 03, OP 79 P 92, P 233Meese, E. P 373Megger, D. P 10Mehr, A. P 180Meier, M. P 262Meiler, A. OP 64Meissner, F. OP 82, P 335Meixenberger, K. P 98Mellors, J. P 390Menegatti, J. P 329, P 373Mengji, L. P 341, P 428Menne, C. OP 40, P 20Mercé-Maldonado, E. P 04Mercer, J. P 414Merkler, D. OP 46, P 117Mernberger, M. P 322Mertins, P. P 329Mese, K. P 288, P 68Messerle, M. OP 84, P 442Mettenleiter, T. C. IL 02 OP 109, P 55, P 165, P 166 P 174, P 181, P 202, P 220 P 257Metzger, K. OP 33Meuleman, P. P 179Meyer, D. P 16, P 175Michael, N. OP 73Michailidis, E. OP 45Michalski, M. P 377Michel, D. SL 02Michel, M. SL 02Michel, S. P 46Mielke, S. OP 11Mika, A. OP 08, OP 10Mikuličić, S. P 285Milbradt, J. P 34, SL 01Millen, S. OP 31, P 227Ming, Z. P 341Mirazimi, A. P 150

Mirko, T. P 69Mirza, Z. P 29Mix, C. P 14Mlakar, J. P 60Möckel, M. P 77, P 259Moeini, H. OP 114Moeller, N. OP 53, P 179Moeller, R. P 163, P 335Moench, E. P 60Moench, S. OP 56Mohr, L. P 177Moldenhauer, A.-S. P 420Moller, R. OP 18Moming, A. P 300Mönch, T. P 118Monk, P. N. P 285Montefiori, D. C. OP 74 P 251Moog, C. P 246, P 255Moore, P. S. OP 35Morath, K. P 356Moreno, H. P 163Moritz, A. P 109Morrison, E. P 318Morsy, E. A. P 253, P 256Moseholm Larsen, E. P 60Möser, C. P 53Moskorz, W. P 417Moss, A. P 298Mostafa, A. P 181, P 204Mostajo-Berrospi, N. P 147Moulton, H. P 322Mouly, V. OP 97Mounogou Kouassi, N. P 273Muehlfeld, A. P 101Muenchau, S. OP 63, P 385Mühl-Zürbes, P. P 208 P 355Mühlebach, M. D. OP 78Müller, Alexander P 185Müller, Alexandra OP 26Müller, A. P 87Müller, C. P 181, P 311 P 324Müller, C. S. L. OP 33Müller, Ja. P 184, P 265 P 400Müller, Jo. OP 20, P 105 P 169, P 186Müller, L. P 38Müller, M. A. OP 44, P 271 P 405Müller, M. P 235Müller, R. P 212Muller, Y. P 218, P 409Muluneh, A. P 79Münch, J. P 47, P 184 P 265, P 291, P 400Münk, C. P 125, P 130, P 336, P 398

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Muñoz-Fontela, C. OP 20 P 193Münscher, A. P 224Munz, C. P 397Münz, M. P 41Muscolino, E. P 378Mutz, P. P 370

NNagel, A. P 93Naguib, M. P 204Naimo, E. OP 84, P 223Nalesnik, M. A. OP 35Nambulli, S. P 75Naniima, P. OP 84, P 223Nassal, M. OP 01, OP 107 OP 54Nathues, H. P 80Naumann, S. P 293Nehlmeier, I. P 420Nehls, J. P 420Neil, S. J. P 441Nelson, P. P 28Nersisyan, S. OP 59Netz, R. P 31Neumann, B. OP 29Neumann, E. P 188Neumann, M. OP 07, P 28Neumann, R. SL 04Neumann-Haefelin, C. P 15Neyts, J. P 66Nguyen-Dinh, V. OP 89 P 320Nicolay, W. P 163Niedrig, M. P 167Niendorf, S. P 302Niesler, B. OP 63Niesters, B. P 167Nieuwenhuijse, D. P 05Nijmeijer, B. M. OP 110Niller, H.-H. OP 29, OP 102Nilsson, J. P 147Nist, A. P 322Nitsche, A. P 106Nivia, D. OP 49Nobach, D. OP 29, P 159Noll, M. P 294Nordhoff, C. P 196Nouri, N. P 162Nürnberger, C. OP 78

OOberhausen, K. P 64Oberhuber, M. P 431Obermann, W. P 311Obermeier, M. P 51, P 58 P 98P, 109Odia, I. P 105Oellig, F. P 114Oestereich, L. OP 20, P 105 P 169, P 186, P 193Oeverby, A. P 335

Ogbaini-Emovon, E. P 105 P 186, P 193Oiknine-Djian, E. P 423Okba, N. SL 04Olajide, O. M. SL 06Olayinka, O. P 297Ollmann Saphire, E. P 226Olokor, T. P 186Olschewski, S. P 217Ölschläger, S. P 105Olsen, B. P 204Omiunu, R. P 186Opaleye, O. O. P 302Oppermann, J. OP 25Osei Kuffour, E. P 398Osman, N. A. P 138, P 286Osterhaus, A. OP 02, P 05 P 164, P 176Osterman, A. P 115, P 90Ostermann, E. OP 13 P 376, P 378, P 435, P 347Ostermann, P. N. P 38Osterrieder, N. P 254Österwinter, K. P 71Otoo, D. P 49, P 229Otto, L. SG 05Överby, A. OP 38

PPahl, D. P 278Pahlmann, M. P 105, P 186 P 193Pallasch, E. P 105, P 169 P 193Panagiotidis, G.-D. P 382Pandey, A. P 131Pannhorst, K. P 55Panning, M. OP 26Pantaleo, G. OP 74Papatheodoridis, G. V. P 43Park, Y. P 247Parvin, R. P 148, P 173Passos, V. P 335, P 386Patel, K. P 105Patil, A. P 196Patzina-Mehling, C. P 96Pauker, V. I. P 124Paul, A. P 393Pawletko, K. P 347Pei, R. P 340Peiffer, K.-H. P 161, P 214 P 362Peine, S. P 175Pelkmans, L. P 440Pena, V. P 274Pendzialek, J. P 41Peng, J.-Y. P 279, P 280Penner, I. P 364Penninger, J. P 309Penzel, A. P 365Percivalle, E. OP 03Pervolakari, K. OP 42

Peter, A. S. OP 76Peteranderl, C. OP 66, P 76Petereit, A. P 79Peterhoff, D. OP 74, P 246 P 255Peters, T. P 266Petersen, B. P 55Petric, P. P 203Petzsch, P. P 414Peus, E. P 177Pfaff, F. P 124, P 157Pfaffinger, V. OP 101Pfaller, C. K. OP 59Pfänder, S. OP 103, OP 45Pfankuche, V. M. P 175 P 176, P 195Pfeffer, K. P 38Pfeffermann, K. OP 95Pfitzner, A. P 120Phan, Q. V. P 143Philippot, S. P 45Pichler, H. P 78Pichlmair, A. OP 64, P 442 SL 03Pietsch, C. OP 111Pietschmann, T. OP 106 OP 18, OP 23, OP 82 OP 91, P 163, P 188 P 216, P 248, P 319 P 339, P 437, P 407Pijlman, G. P 259Pinschewer, D. OP 46 P 117Pipperger, L. P 413Pischke, S. P 104Pissani, F. OP 73Pitisuttithum, P. OP 73Piwowarczyk, A. P 68Plachter, B. OP 86, P 360 P 364Plank, V. OP 54, OP 107Plath, M. P 321Plattet, P. P 207Plemper, R. OP 95Pleschka, S. OP 66, P 181 P 76Plesker, R. OP 95Pluskota, B. P 183Podgórska, M. OP 33Podlech, J. P 02Poetsch, J. H. S. SL 04Pogan, R. P 278Pohlmann, Anj. P 49, P 229 P 436Pohlmann, Ann. OP 81 P 170, P 177Pöhlmann, S. OP 15, OP 16 OP 44, P 62, P 67, P 84 P 110, P 178, P 180 P 200, P 272, P 284 P 290, P 400, P 420Polywka, S. P 175

Ponnurangam, A. P 436Popping, S. P 60Port, J. R. OP 20, P 193Portugal, R. P 138Poshtgohian Madi, A. P 365Postel, A. P 16, P 195 P 245Potratz, M. OP 70, P 182Pott, F. P 188Potthoff, A. OP 30, P 114Praditya, D. P 179Praefcke, G. P 162Prange, R. P 206Preising, N. P 47Preisinger, C. P 328Preugschas, H. F. P 345Prifert, C. OP 26, P 60Prinz, I. OP 22Proff, J. P 41Protzer, U. OP 54, OP 107 OP 114, P 06, P 42, P 244 P 439Przybylski, M. P 81, P 82Ptok, J. P 145Puchhammer, E. P 275Puchhammer-Stöckl, E. P 395Puff, C. P 176Puhach, O. P 435Pun, R. P 199Punyadarsaniya, D. P 279

QQi, J. P 24, P 231Qian, F. P 70Qian, L. P 09, P 428Qin, C. P 24Qu, B. OP 56

RRabe, T. OP 113Rabenau, H. F. P 93Rackow, A. OP 08, OP 10Rad, R. OP 64Radu, M. P 43Rahn, E. P 259Rakasz, E. P 249Rall-Scharpf, M. P 313Rameix-Welti, M.-A. OP 91Rammensee, H.-G. P 235Ramos-Nascimento, A. P 440Ramsbeck, D. P 53Ran, W. OP 50, OP 77 P 170Ranganathan, S. OP 35Rao, C. D. P 326Rascle, A. OP 11, P 101Rastrojo, A. OP 88Rataj, O. P 27Ratto-Kim, S. OP 73Raupach, R. OP 94

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Rautenschlein, S. P 177Read, C. P 205Real, C. P 393Reddehase, M. J. P 02, P 18Regen, T. OP 46Regensburger, K. OP 58Rehage, J. P 175Reich, J. P 411Reiche, S. P 80, P 220Reichel, A. OP 39Reichl, U. P 62, P 67Reimer, R. P 224Reindl, S. OP 51, P 116, P 217Reinert, A. P 342Reinhard, H. P 04Reischl, U. OP 29Reiser, J. P 185Remy, M. OP 46Renders, L. P 101Rennert, P. P 433Rennick, L. P 75Renzaho, A. OP 102Rerks-Ngarm, S. OP 73Rescher, U. P 32Resner, K. OP 53Reuter, F. P 362Reuter, N. OP 39, P 59Reuter, S. P 02Reuther, P. P 117Rey, F. A. OP 79, OP 80 P 257Ribeiro Nogueira, R. M. OP 08, OP 10Rice, C. SL 03, OP 45Richter, E. P 40Rieder, G. OP 29Riederer, S. OP 99Riedl, A. P 293Riemenschnieder, M. J. OP 29Ries, F. P 02Riess, M. OP 56, P 397Rijsbergen, L. P 75Rimmelzwaan, G. OP 02Rissland, J. OP 25Rissmann, M. P 160Ritter, B. OP 88, P 372Rivière, L. P 379Rizzato, M. OP 14, P 378Roan, N. P 184Robb, M. OP 73Robens, C. P 335Röcker, A. P 47Rockstroh, J. P 51Röder, J. P 273RodrÍguez Barbosa, J. I. P 37Roeder, A. P 286Roggendorf, M. OP 06

Rogowska, J. P 81, P 82Rohde, C. P 147, SL 04Rohn, H. P 72Rohrhofer, A. P 250Rojas, J. J. OP 99Rongjuan, P. P 341Roos, W. H. P 278Ros, C. P 210Roßbacher, L. P 92Rosenthal, M. OP 51, P 116 P 217Ross, J. A. OP 21Ross, J. J. OP 32Ross, S. P 86, P 98Rossini, G. OP 69Rosu, M. OP 81Roth, H. P 305Roth, N. J. P 210Rothemund, F. P 409Rother, F. P 281Rouvinski, A. OP 79Rubbenstroth, D. OP 29 P 177Rubin, S. P 270Rückborn, M. P 69Rückert, J. OP 91, P 49 P 52Rückner, A. P 107Ruelle, J. P 51Rufinatscha, K. P 357Rüggeberg, T. P 200Ruibal, P. OP 20Ruijs, W. P 05Rümenapf, T. P 139Ruokolainen, V. P 222Ruzsics, Z. P 293, P 402Ryffel, B. OP 64Ryoo, G. P 247Rziha, H.-J. P 235

SSabino, C. P 50, P 268Sacherl, J. P 244Sachsenhauser, T. P 353Sadewasser, A. P 46Saeed, M. OP 45Saelens, X. OP 99Sahin, M. OP 46Salaheldin, A. P 166, P 174 P 202Salem, H. A. P 253, P 256Saliba, A.-E. OP 61, OP 106Salzer, B. P 41Sanders, R. P 246, P 255Sandi-Monroy, N. P 184Sang, R. OP 71Sarrazin, C. P 86Sattentau, Q. P 246, P 255Sauder, C. P 270Sauerhering, L. OP 02

Sauter, D. OP 37, P 391 P 400, P 408Sawatsky, B. P 134Scaturro, P. SL 03Schaade, L. P 389Schaal, H. P 38, P 366Schachtner, M. P 246Schädler, J. P 236Schaefer-Eckart, K. OP 11Schäfer, W. P 210Schaft, N. P 208, P 250Schaller, T. P 325Schampera, M. P 65Schauflinger, M. P 205Scheer, P. P 80Scheffler, K. P 342Scheibner, D. P 165, P 166 P 174, P 202Schelhaas, M. OP 14, P 278Schemmerer, M. P 101 P 151Schenk, C. P 346, P 370Scherbaum, N. OP 40 P 396Scherer, M. OP 39, OP 52 P 409, P 410Schick, B. OP 25Schiela, B. P 406Schierhorn, K. L. P 441Schilling, E.-M. OP 52 P 409Schilling, H. P 386Schimmer, S. P 37Schindler, M. P 118, P 420 SL 01Schinköthe, J. P 170, P 17 P 262Schiwon, M. P 288Schlaak, J. P 393Schlagowski, S. P 272 P 277Schlaphoff, L. P 84Schleif, M. P 419Schloer, S. P 32Schlottau, K. OP 29, P 159Schlötzer-Schrehardt, U. P 212Schlüter, H. P 435Schmalz, H.-G. P 50Schmalzl, C. OP 74Schmanke, P. P 317Schmelz, S. P 394Schmerer, P. P 309Schmidt, A. P 230Schmidt, B. OP 29, P 250Schmidt, C. P 52Schmidt, D. P 60, P 98Schmidt, F. I. P 401Schmidt, L. OP 112Schmidt, M. P 376

Schmidt, T. OP 11, P 101Schmidt-Chanasit, J. OP 08 OP 10, OP 28, OP 29 OP 69, P 167, P 183 P 184Schmidtke, M. P 36Schmiedeke, J. K. P 18 P 399Schmiedel, S. SL 04Schmitt, S. OP 31Schmitz, H. OP 08Schmitz, J. E. P 251Schmitz, J. P 113Schmitz, K. P 242Schmitz, R. P 378Schneider, A. SL 01Schneider, C. P 224Schneider, G. P 44Schneider, J. OP 72Schneider, M. P 235, P 310Schneider, N. F. Z. P 57Schneider, S. P 237Schneider, W. SL 03Schnepf, D. OP 64, P 01Schnettler, E. P 102, P 392Schnierle, B. P 39Schöbel, A. P 334Schoelzel, A. P 289Schoen, A. P 405Schoggins, J. W. OP 45Scholl, C. P 317, P 321Scholl, L. P 331Schollmeier, A. P 162Scholz, B. P 354Scholz, T. P 39Schön, J. OP 50, OP 77Schöneweis, K. OP 94Schöniger, S. P 84Schönmann, U. P 110Schott, K. P 312, P 313Schotta, G. P 391Schountz, T. P 170Schreder, M. OP 11Schreiber, A. P 230, P 26Schreier, S. OP 38, P 198Schreiner, S. OP 39, OP 54 OP 107, P 348, P 375 P 438, P 439Schubert, A. P 184, SL 02Schüer, L. P 91Schughart, K. P 48Schuhenn, J. P 411Schuler-Thurner, B. P 250Schulte, B. OP 73Schulte, F. W. P 311Schulte, J. OP 93Schulte, L. P 295Schultz, B. OP 73Schulz, T. P 49, P 52

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We take over your lab developed test (LDT) preparation and deliver a ready-to-use solution in line with ISO15189 requirements.

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Schulz, T. F. OP 49, OP 84 OP 91, P 64, P 74 P 178, P 223, P 339Schulze, C. P 177Schulze, J. OP 66, P 76Schulze, J. P 392Schulze zur Wiesch, J. P 15 P 42Schumachers, P. P 401Schumann, G. G. P 334Schürer, S. P 389Schüssler, M. P 312, P 313Schuster, M. P 40Schuster, P. P 250Schuster, T. P 132Schüttler, C. P 61Schütze, E. P 84Schütze, M. P 109Schwaiger, J. P 89Schwanke, H. P 394Schwartz, O. P 386Schwarz, F. OP 07Schwarz, T. P 15, P 19 P 127Schwarzmüller, M. OP 24Schwegler, C. OP 102Schweiger, B. P 88Schweininger, J. P 409Schweinoch, D. P 131Schwemmle, M. SL 03 SL 06, OP 29, OP 50 OP 77, OP 81, P 62 P 170, P 172, P 228 P 230, P 262Schwerdtfeger, M. OP 103Schwickert, J. P 285Schwindt, S. P 209Seders, M. P 48Seeberger, P. P 31Seebohm, G. P 230Seeger, J. P 342Segura-Wang, M. P 395Sehl, J. OP 109Sehn, E. OP 86Seidel, E. P 423Seidl, M. OP 67Seifert, T. P 79Seifried, J. P 397Seitz, K. P 139Seitz, S. P 407Selbach, M. P 376Selinka, H.-C. OP 72Sellau, J. P 387Sellrie, K. P 31Selvakumar, B. P 76Selvaraj, P. P 344Senff, T. OP 40, P 20, P 396Serrero, M. OP 55, P 28, P 3491Sertznig, H. P 128, P 411

Sezgin, E. OP 17Shafiq, M. P 25Shair, K. H. OP 35Shang, Z. P 231Shao, Y. P 140, P 56Shcherbakova, I. P 391Shen, S. P 300Sherifi, K. OP 08Shi, J. P 300Shi, R. P 24Shi, T. P 230Shi, Y. P 24, P 231, P 287Shi, Z.-L. P 192Shin, D.-L. P 279, P 280Shin, H.-J. P 232Shin, Y. P 249Shu, Y. OP 27Shuhui, L. P 341Sichelschmidt, S. P 30Sickmann, A. P 347, P 378Siebels, S. OP 104Sieben, C. OP 17Siebert, U. P 164Sieg, M. P 107, P 342Siemens, N. P 403Sierra, S. P 51Sigrist, B. P 94, P 236Silling, S. OP 30, P 114Simmons, G. OP 18, P 400Simões, C. M. O. P 57Sinclair, J. IL 14Singethan, K. P 42, P 244Sinzger, C. P 71, P 108 P 285Sitek, B. P 10Sitnik, K. OP 62Skibbe, K. P 396Slanina, H. P 61Smith, D. P 53Smola, S. OP 25, OP 33 OP 60, OP 92 OP 100, P 363Snijder, B. P 440Snijder, E. J. P 66Socher, E. P 227, P 314 P 34, P 360Sodeik, B. OP 15, OP 47 OP 55, OP 83, OP 84 OP 88, P 49, P 208, P 222 P 229, P 281, P 349, P 436 P 440Soh, T. P 224Sohrab, S. S. P 29Solomayer, E.-F. OP 33 OP 60, P 363Sommer, M. OP 92Sommerauer, C. P 335Sommerer, C. P 101Song, H. P 231Song, J. P 24

Sönnerborg, A. P 58, P 60Sonntag, E. P 212, P 218 P 34Sparrer, K. OP 58, P 47 P 400Speckmann, C. P 87Spengler, C. P 214, P 263 P 264Speranza, E. OP 20, P 193Spiegelberg, C. P 100Spieler, E. E. P 383Spindler, T. P 101Spohn, M. OP 36, OP 104Sreenu, V. B. P 392Srinivasachar Badarinarayan, S. P 391Sriplienchan, S. OP 73Srivaratharajan, S. OP 88Stab, V. OP 19Stadler, D. OP 54, OP 107 P 439Stadtmüller, M. P 31Staeheli, P. P 01Stäheli, P. IL 10, OP 64Stalder, H. OP 45Stamminger, T. OP 39 OP 52, P 327, P 409 P 410, SL 02Ständker, L. P 47Stanelle-Bertram, S. P 387Stang, A. P 190Stanifer, M. OP 42, OP 63 P 385, P 434Stanke, N. P 397Stassen, M. P 399Steffen, I. P 154, P 156Steger, G. OP 34Stein, D. A. P 322Stein, N. C. P 230Stein, S. C. P 64Steingruber, M. P 314 P 34, P 360Steinhagen, D. P 89Steininger, P. P 152Steinkasserer, A. P 208 P 355Steinmann, E. OP 53, P 44 P 179, P 190, P 316 P 339, P 407Steinmann, J. P 179Stelling, N. P 403Stepanova, T. OP 94Stephanowitz, H. P 344Steppe, L. P 47Stern-Ginossar, N. P 412Stertz, S. OP 108, P 258 P 262, P 269, P 383Steubl, D. P 101Stevens-Ayers, T. P 85

Stiasny, K. OP 03, OP 79 P 03, P 92, P 233, P 406Sticht, H. P 59, P 227 P 314, P 34, P 360Stilp, A.-C. OP 39, P 410Stindt, S. P 357Stingl, J. P 317, P 321Stöckle, M. OP 92Stögerer, T. P 275Stöhr, D. P 71Stöhr, R. P 152Stoiber, H. OP 21, P 406 P 413Stolp, B. P 356Storcksdieck genannt Bonsmann, M. OP 19Straub, E. P 118Straub, T. OP 67Strecker, T. P 225Streeck, H. P 359, P 40 P 417Ströder, R. OP 33, OP 60 P 363Stroeh, L. J. OP 84, P 248Stubbe, M. P 375, P 439Stubenrauch, F. P 118 P 235, P 27, P 310, P 384Stukalov, A. SL 03Stürmer, M. P 51Su, A. P 283Su, J. P 06Su, Z. P 300Suarez, H. P 285Suarez, N. P 178Sun, B. P 70Sun, J. P 21Sun, S. P 300Surabhi, S. P 403Sutter, G. OP 99, P 111 P 187, P 23, P 296, P 89 SL 04Sutter, K. OP 04, OP 103 OP 57, P 128, P 238, P 30 P 386, P 411, P 48Svrlanska, A. P 327Swanson, C. M. P 441Swerdlow, S. H. OP 35Swoboda, J. P 114

TTabari, D. P 317, P 321Taju, A. P 186Takamatsu, Y. P 201, P 211Tan, C. W. P 192Tandra, V. P 326Tang, J. OP 13, P 351Tang, S. P 300Tannich, E. OP 69, P 102 P 183Tannig, P. OP 76

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Tanriver, Y. P 01Tao, R. P 421Tao, S. P 17, P 421Tappe, D. OP 29Taube, C. P 02Taube, S. P 289Tausch, S. P 96Taute, S. OP 34Tautz, N. P 119, P 209Tavares, L. P 22Taylor, N. P 51Tchouassi, D. OP 71te Kamp, V. OP 70Tebbe, F. P 321Tegtmeyer, B. P 190, P 407 P 437Tegtmeyer, P. P 436Teifke, J. P. OP 109Teixeira, M. P 22Tekes, G. P 221Temchura, V. OP 76Tenbusch, M. OP 19, OP 76 P 240, P 241Teschner, D. OP 11, P 02Tesfamariam, Y. M. P 401Teufert, N. P 41Tewes, S. P 424Thamamongood, T. P 262Tharmapalan, V. OP 103Tharra, T. P 147Theis, F. OP 61Theiß, J. P 122Theiss, J. OP 104Theissen, M. P 15, P 19 P 127Thelemann, T. P 46Thiel, V. OP 45Thiele, C. P 261Thielebein, A. P 105, P 186Thielens, N. P 406Thimme, R. P 15Thirion, C. P 240Thoma-Kress, A. K. OP 31 P 227Thomann, S. P 250Thomas, D. SL 01Thomas, M. P 34, P 59Thomas, S. OP 102, P 364Thomson, E. P 08Thöns, C. OP 40, P 417 P 424Tigoi, C. C. OP 71Timm, J. OP 09, OP 40 OP 112, P 15, P 19, P 20 P 127, P 396, P 417, P 424Timmer, L. P 30, P 359Timothy, J. P 171Tipton, T. P 07, P 08, P 171 P 390Tobin, E. P 105

Todt, D. OP 23, OP 53 P 179, P 190, P 316, P 339Todt, H. P 367Tomaras, G. OP 74Tomas, L. P 45Tomaszewska, A. P 81, P 82Tong, Z. P 24Tongchaeroen, P. OP 73Toptan, T. OP 35Torto, B. OP 71Tran, C. S. P 370Tran, V. Q. G. P 345Traut, J. P 415Trautz, B. P 356Treckmann, J. P 393Treitz, J. OP 33, P 363Trilling, M. P 95, P 146 P 412, P 423Trippler, M. P 393Trivedi, P. P 373Trkola, A. P 246Trummer, S. OP 91Tschismarov, R. P 242Tsogoeva, S. B. P 34Tsouchnikas, G. OP 03 P 233Tufa, T. B. P 58Tuku, B. P 387Turan, A. P 208Turkington, H. OP 108Tvarogová, J. P 123Twizerimana, A. P. P 336

UÜberla, K. OP 76, P 93Uckeley, Z. P 335Uetrecht, C. P 217, P 266 P 278Ulrich, L. OP 68Ulrich, R. G. P 157Ulrich, R. P 160, P 166 P 170, P 172, P 177, P 262Urban, C. SL 03Urban, S. OP 01, OP 56 OP 94Usman, Z. OP 114

VVafadarnejad, E. OP 106Vágó, N. P 414Vahlenkamp, A. P 342Vahlenkamp, T. W. P 107 P 342Vallbracht, M. P 257van Binnendijk, R. S. OP 02van de Bildt, M. P 164van den Boom, A. OP 97van den Ham, H.-J. P 05van den Heuvel, J. P 394van Dyck, L. P 176

Van Hoecke, L. OP 99van Lent, J. P 259van Nieuwkoop, S. OP 110van Zelm, M. P 05Vaney, M.-C. OP 79Vanshylla, K. P 291Vapalahti, O. P 183Varbanov, M. P 45Vattipally, S. P 102Veit, M. P 261, P 318Veit, S. P 23, P 187Veits, J. P 166, P 174, P 202Verbeek, M. OP 11Verburgh, J. OP 02, P 05Verhagen, J. P 204Verheugd, P. P 328Verheyen, J. P 128, P 83Veselkova, B. OP 15, P 248Vetter, B. P 122, P 376 SL 01Viehweger, A. P 142Viejo-Borbolla, A. OP 88 P 372Vietzen, H. P 395Vieyres, G. OP 82, P 216 P 319, P 437Vihinen-Ranta, M. OP 83 P 222Villalonga-Planells, R. OP 14Villalvazo Guerrero, J. C. P 49Visser, E. P 05Vogel, D. P 116Vogel, U. P 308Vogelgesang, M. OP 60 P 363Vogt, C. P 74Voigt, K. P 271Voigt, S. OP 93, P 432Volkmann, B. OP 32Volz, A. P 23, P 111, P 187 SL 04von Brunn, A. P 337, P 66von Creytz, I. P 147von Einem, J. P 184, P 205 P 265von Hahn, T. OP 15, P 44 P 86von Laer, D. P 237, P 251 P 413von Lilienfeld-Toal, M. OP 11von Messling, V. OP 95 P 133, P 134von Possel, R. OP 08Vondran, F. W. R. P 179 P 319, P 359, P 437Voortmann, S. P 208Voronkova, N. OP 94

Voß, J. P 329Voss, Y. P 335V`kovski, P. OP 45

WWachowius, M. P 431Wagner, E. OP 11Wagner, R. OP 11, OP 102 OP 74, P 85, P 101, P 132 P 246, P 251, P 255Wahl, B. P 120Walch-Rückheim, B. OP 100Walendy-Gnirss, K. P 331Walker, A. OP 09, P 127 P 15, P 19, P 396 P 424, SG 01Walotka, L. P 366Walter, S. P 368Walther, M. P 80Walther, P. P 205Walther, T. P 119Wamara, J. P 276Wang, Ba. OP 41, P 430Wang, Bo P 153, P 302Wang, Chen P 56Wang, Cheng P 300Wang, H. P 70Wang, Hu. P 300Wang, Jun P 300Wang, Junz. P 24Wang, L.-F. P 192Wang, L. Op 44Wang, Q. P 24Wang, S. P 427Wang, X. OP 90, P 323Wang, Z. P 140Wangen, C. P 218, P 34Waszczuk-Gajda, A. P 81 P 82Wawina-Bokalanga, T. P 416Weber, A. P 343, SL 05Weber, F. P 150, P 309 P 382, P 405, P 418, SL 05Weber, J. P 397Weber, S. P 157Wedde, M. P 33, P 88Wedemeyer, H. OP 53 OP 94, P 15, P 43, P 97 P 393Wehweck, F. P 90Wei, R. P 262Weidner, N. P 294Weidner-Glunde, M. OP 49Weigang, S. OP 55Weinhardt, V. P 222Weiß, C. P 439Weisbach, H. P 376Weiss, F. P 90

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Weiss, G. P 406Weiss, S. P 191Weissbrich, B. OP 26Weissenhorn, W. P 246 P 251Weisshaar, J. OP 33Wekerle, T. P 101Welch, S. P 102Wells, S. P 438Wen, X. OP 87Wendt, L. OP 43Wendt, M. P 16Wenzek, C. P 381Wenzel, J. OP 29, P 72 P 151, P 167Werner, A.-D. P 226Werner, M. P 393Werner, T. P 10, P 37Werner-Klein, M. P 250Wernery, U. P 239West, J. P 273Westendorf, A. OP 19 P 238, P 381Westhaus, S. OP 103, P 30 P 359, P 95Wetzke, M. P 339Whisnant, A. P 141, P 329 P 377Widera, M. P 38, P 83 P 95, P 128, P 411Widmer, D. P 178Wiebe, K. P 48Wiebusch, L. P 122, P 143 P 376, SL 01Wiechers, C. OP 62Wiechert, S. M. OP 91Wiegand, M. A. OP 102Wiegmann, B. OP 91, OP 106, P 339Wieland, U. OP 30, P 114Wiener, J. P 262Wieseler, J. P 419Wiesmüller, L. P 313Wiesner, L. P 154Wiewrodt, R. P 48Wifling, K. P 63Wild, N. P 413Wilde, B. P 83, P 128Wildemann, J. P 379Wille, M. P 204Williams, R. P 74Willscher, E. P 374, P 434Wilmschen, S. P 237, P 251Wilson, H. P 441Winkelmann, M. P 108Winkler, E. P 365Winkler, F. P 355Winkler, M. P 62, P 67 P 180, P 400

Winkler, T. SL 01, P 59Winter, F. P 166Winterpacht, A. OP 39Wirtz, L. P 77, P 259, P 260Witt, V. P 78Wittmann, S. OP 32, P 332 SL 01Wittwer, K. OP 95Witzke, O. OP 06, P 72 P 83, P 101, P 128Wixler, L. P 230Wixler, V. P 196Wolf, D. G. P 423Wolf, L. OP 31Wolf, S. OP 06Wölfel, S. OP 03Wolff, D. OP 11Wolff, T. OP 66, P 31, P 76 P 88, P 422Wolfrum, N. P 94, P 236Wolfrum, U. OP 86Wollmann, G. P 413Wolschke, C. OP 11Wong, G. P 24Wong, L. P 119Wong, T. A. OP 75Wonneberger, H. P 194Wörz, S. P 409Wozniak, D. M. OP 20 P 169, P 193Wroblewska, M. P 81, P 82Wu, C. P 341Wu, J. OP 41Wu, L. P 24Wu, N.-H. P 279, P 280Wu, Qia. P 300Wu, Qin. P 214, P 215 P 263, P 362Wu, Y. P 24Wuerth, J. D. P 418Wulle, J. P 405Wunderlich, K. P 48Wunderlich, S. OP 29Würzner, R. P 406Wyler, E. P 329, P 368Wylezich, C. P 177

xXi, J. P 235Xi, S. P 340Xie, H. P 85Xie, J. P 404Xie, Y. P 429Xing, H. P 56Xinwen, C. P 341Xu, S. P 386, P 436Xuan, H. P 09Xue, H. P 340, P 341Xueyu, W. P 428

YYalcin, K. P 43Yamin, R. P 423Yan, Ha. P 266, P 278Yan, Hu P 425Yan, Hui P 09, P 425Yan, J. P 24Yáñez-Mó, M. P 285Yang, Dongliang OP 4 P 09, P 69, P 429, P 430Yang, H. P 24Yang, J. P 300Yang, M. P 24Yang, R. P 70Yang, Ro. P 70Yang, X. P 192Ye, L. P 01Yifei, Y. P 341Yigitliler, A. P 235, P 310Yilma, T. D. P 24Ying, Z. P 428Yinglong, S. P 428Yingshan, C. P 341Yinwen, C. P 340Yong, L. P 428Yongxuan, Y. P 341Yu, Q. P 429, P 430Yuan, T. P 70Yuan, Z. P 341Yue, C. P 305Yuecheng, Y. P 428Yun, W. P 340, P 341Yurdaydin, C. P 43

ZZaeck, L. OP 70, P 182Zagordi, O. OP 108Zahn, T. P 243Zapatero-Belinchon, F. OP 15, P 44Zaruba, M. P 105Zazzi, M. P 58, P 60Zech, F. P 400Zegenhagen, L. OP 38Zeichhardt, H. P 61Zeier, M. P 185Zelinskyy, G. P 10, P 37 P 238Zeng, H. P 24Zeuzem, S. P 161, P 43Zeyen, L. P 206Zhang, E. P 425Zhang, G. OP 49Zhang, J. P 300Zhang, Lib. P 192Zhang, Lin. P 66Zhang, Wie P 192Zhang, Wen OP 97, P 288 P 295

Zhang, X. P 09Zhang, Ya. P 300Zhang, Yua. P 56Zhang, Yud. P 407Zhang, Yuj. P 300Zhang, Y.-Z. P 192Zhang, Ze. P 125, P 336Zhang, Zh. P 393Zhang, Z. P 300Zhao, Z. P 24Zheng, A. P 252Zheng, X. OP 41, P 430Zhou, P. OP 48, P 192Zhou, Q. P 404Zhou, W. P 429Zhu, C. P 70Zhu, F. P 369Zhu, L. P 300Zhu, Y. P 192Ziebuhr, J. P 61, P 123 P 135, P 221, P 311Ziegler, U. OP 28Ziehuhr, J. P 324Zigrino, P. P 353Zillinger, T. OP 47, P 386 P 401, P 436Zimmer, A. P 234Zimmer, G. OP 45, P 262Zimmer, M. P 365Zimmermann, Al. P 145 P 380Zimmermann, And. P 200Zimmermann, Ani. P 61Zimmermann, C. OP 86 P 364Zimmermann, J. P 90Zinser, M. E. SL 04Zirafi, O. P 291Zirkel, F. OP 71, P 189 P 199Zoelfakar, S. A. P 256Zoelfakkar, S. A. P 253Zou, S. OP 41, P 430Zscheppang, K. P 48Zuk-Wasek, A. P 81, P 82

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POSTER SESSION 1

PREVYMIS® ist der erste und einzige CMV-DNA-Terminaseinhibitor, der speziell zur Prophylaxe einer Cytomegalievirus (CMV)-Reaktivierung und -Erkrankung bei erwachsenen CMV-seropositiven Empfängern [R+]

einer allogenen hämatopoetischen Stammzelltransplantation (hematopoietic stem cell transplant [HSCT]) zugelassen ist.

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PREVYMIS®

PREVYMIS® 240 mg FilmtablettenPREVYMIS® 480 mg FilmtablettenPREVYMIS® 240 mg Konzentrat zur Herstellung einer InfusionslösungPREVYMIS® 480 mg Konzentrat zur Herstellung einer InfusionslösungWirkstoff: Letermovir Zus.: -240 mg/-480 mg Filmtbl.: Arzneil. wirks. Bestandt.: 1 Filmtbl. enth. 240 mg/480 mg Letermovir. Sonst. Bestandt.: Tablettenkern: Mikrokristalline Cellulose (E 460), Croscarmellose-Natrium (E 468), Povidon (E 1201), Siliciumdioxid (E 551), Magnesiumstearat (E 470b). Filmüberzug: Lacto-se-Monohydrat, Hypromellose (E 464), Titandioxid (E 171), Triacetin (E 1518), Eisen(III)-hydroxid-oxid (E 172), Eisen(III)-oxid (nur 480-mg-Filmtabletten) (E 172), Carnaubawachs (E 903). -240 mg/-480 Konz.: Arzneil. wirks. Bestandt.: 1 Durch-stechfl. enth. 240/480 mg Letermovir. 1 ml enth. 20 mg Letermovir. Sonst. Bestandt.: Hydroxypropylbetadex (Cyclodextrin), Natriumchlorid, Natriumhydro-xid (E 524), Wasser für Injektionszwecke. Anw.: Zur Prophylaxe e. Cytomegalie-virus(CMV)-Reaktivierung u. -Erkrankung b. erw. CMV-seropositiven Empfängern [R+] einer allogenen hämatopoetischen Stammzelltransplantation. Gegen anz.: Überempf.-keit gg. d. Wirkstoff od. e. d. sonst. Bestandt. Komb. mit Pimozid od. Mutterkorn alkaloiden. B. Komb. von Letermovir u. Ciclosporin: Komb. mit Dabi-gatran, Atorvastatin, Simvastatin, Rosuvastatin od. Pitavastatin. Stillzeit. Vor-sicht bei: Anw. > 100 Tage. Pat. mit terminaler Niereninsuff. mit od. ohne Dialyse. Komb. mit Ciclosporin, Tacrolimus, Sirolimus. Komb. mit AM, die CY-P3A-Substr. mit ger. ther. Breite sind (z. B. Alfentanil, Fentanyl u. Chinidin). Komb. mit Voriconazol od. Phenytoin. Komb. m. AM, die von OATP1B1/3 transportiert werden (z. B. viele Statine). Vermeiden: Komb. m. Dabigatran. Nicht empf.: Pat. m. schwerer Leberfunkt.-stör. (Child-Pugh Klasse C), Pat. m. mäßiger Leber-funkt.-stör. u. gleichz. besteh. mäßiger od. schwer. Nierenfunkt.-stör. Schwan-gerschaft. Frauen im gebärfähigen Alter, die keine Empfängnisverhütung verw.

Komb. mit versch. Statinen. Filmtbl. zusätzl.: Pat. mit d. selt. heredit. Galacto-se-Intoleranz, Lactase-Mangel od. Glucose-Galactose-Malabsorption. Konz. zu-sätzl.: Pat. mit mäßiger od. schwerer Nierenfunkt.-stör. (Kreatinin-Clearance < 50 ml/min). Pat. unter Natrium kontrollierter Diät. Nebenw.: Häufig: Übelk.; Diarrhö; Erbr. Gelegentl.: Überempfindlichkeit. Vermind. Appetit. Ver änd. d. Ge-schmackswahrnehmung; Kopfschm. Schwindel (Vertigo). Abdom. Schm. Erhöhte ALT; erhöhte AST. Muskelspasmen. Kreatinin im Blut erhöht. Ermüdung (Fatigue); peripheres Ödem. Warnhinw.: -Filmtbl.: Enthält Lactose. Enthält weniger als 1 mmol Natrium (23 mg). -Konz.: Enthält Natrium. Enthält Hydroxypropylbetadex (Cyclodextrin). Hinw.: Konz. muss als i.v. Infusion über 60 Min. gegeben werden u. darf nicht als i.v. Druck- oder Bolusinjektion gegeben werden. Verschreibungspflichtig. Stand: 07/2018Bitte lesen Sie vor Verordnung von PREVYMIS® die Fachinformation!Pharmazeutischer Unternehmer:Merck Sharp & Dohme B.V.Waarderweg 392031 BN HaarlemNiederlandeLokaler Ansprechpartner: MSD SHARP & DOHME GMBH, Lindenplatz 1, 85540 Haar

148x210_AINF-1243749-0003_Prevymis.indd 1 18.02.19 13:43

116

Sample to Insight

QIAstat-DxThe next generation of syndromic insights

The QIAstat-Dx (DiagCORE) is intended for in vitro diagnostic use in Europe.

Trademarks: QIAGEN®, Sample to Insight®, QIAstat-Dx® (QIAGEN Group). DiagCORE® (STAT-Dx Life S.L.) Registered names, trademarks, etc. used in this document, even when not specifically marked as such, are not to be considered unprotected by law.

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