Diversity Plus Panel of BioMAP® Systems
-
Upload
biomap-systems -
Category
Health & Medicine
-
view
5.901 -
download
0
description
Transcript of Diversity Plus Panel of BioMAP® Systems
![Page 1: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/1.jpg)
Bridging the Gap From In Vitro to In Vivo
BioMAP® Diversity Plus Profiling
1
![Page 2: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/2.jpg)
BioMAP® Diversity Plus Panel
12 Systems include a variety of immune and tissue cell types
• Primary human vascular cells (endothelial and smooth muscle), epithelial cells (skin
and lung), fibroblasts, myofibroblasts, T cell, B cell, monocytes, macrophages
• Good blend of co-culture and single cell type BioMAP® Systems
• Format: > 140 biomarker readouts; 4-dose, single well format
• Useful for:
• Mechanism of action studies
• Covers most mechanisms represented in BioMAP Database
• Safety-related compound properties
• Efficacy-related activities for autoimmune or inflammatory disease areas
• Business terms
• Single compound profiling with Terms and Conditions, per compound pricing
• Competitive terms for ongoing profiling agreements or large studies
2
![Page 3: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/3.jpg)
3
BioMAP® Diversity Plus Panel (1-6)
![Page 4: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/4.jpg)
4
BioMAP® Diversity Plus Panel (7-12)
![Page 5: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/5.jpg)
BioMAP® Diversity Plus – Cell Types & Co-cultures
B cells
Endothelial Cells
Bronchial Epithelial Cells
Keratinocytes
Smooth Muscle Cells
Dermal Fibroblasts
Lung Fibroblasts
Peripheral Blood Mononuclear Cells
Macrophages
BioMAP Systems
5
10 primary human cell types
12 assay systems
• Different cell types, co-culture combinations
• Different activation conditions – disease models
![Page 6: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/6.jpg)
BioMAP® Diversity Plus – Biology Covered
Vascular Biology
Wound Healing
Th1 Inflammation
Skin Biology
Th2 Responses
Immune Biology
Th17 Biology
Lung Biology
6
![Page 7: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/7.jpg)
BioMAP® Profiling – Process
7
Compounds
are ShippedCell Culture Data Analysis
Report
Delivery
BioMAPDatabase
Readout Assays
6-8 weeks (12 systems) 1-2 weeks
Automated, Validated
ProceduresSpecially trained staff
Proprietary Database
and Analysis Software
High Throughput Lab
Program Manager
![Page 8: Diversity Plus Panel of BioMAP® Systems](https://reader034.fdocument.pub/reader034/viewer/2022052602/559c17ee1a28abb4428b467b/html5/thumbnails/8.jpg)
Bridging the Gap From In Vitro to In Vivo
BioMAP® Diversity Plus ProfilingContact
Carmen Bryant
Program Manager
BioSeek, LLC
650-416-7647
BioSeek, LLC310 Utah, #100South San Francisco, CA 94080