DENTAL DEFECTS - · PDF file• Hypophosphatemia (Vit D refractory rickets) • Regional...
Transcript of DENTAL DEFECTS - · PDF file• Hypophosphatemia (Vit D refractory rickets) • Regional...
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DENTAL DEFECTS
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Tooth Anomalies, sporadic and genetic
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CLASSIFICATION
• MORPHOLOGY• NUMBER• SIZE• STRUCTURE• ERUPTION DEFECTS
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ALTERATION IN MORPHOLOGY• MICRODONTIA• MACRODONTIA• DILACERATION• DENS IN DENTE• DENS EVAGINATUS• ENAMEL PEARLS• TAURODONTIA• HYPERCEMENTOSIS• FUSION• GEMINATION• CONCRESCENCE• HUTCHINSON’S TEETH
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Microdontia
• Focal or Limited – confined to one or only a few teeth
• Peg laterals• Conical teeth – hereditary
ectodermal dysplasia
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Microdontia
Conical teeth
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Macrodontia
• Focal – a single tooth is enlarged• Generalized – Gigantism• Hemifacial Hypertrophy• Fusion and Gemination
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Macrodontia
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Dilaceration• Difficult to extract
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Dens in dente
• Developmental invagination of enamel organ
• Periapical infections without caries
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Dens Invaginatus, apical abscess
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Dens Evaginatus
• Evagination of enamel organ• Pulp horn protrudes into
evagenated region
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Coronal Anomalies
Cuspal anatomy
Conical crowns
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Enamel Pearl (Enameloma)Nodular round smooth deposit of enamel on the root surface
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Taurodontia• Elongated pulp chambers (bull teeth)
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Hypercementosis
• Osteitis deformans (Paget’s Disease)
• Complicated extractions
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Hypercementosis
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Fusion• Mergence of contiguous teeth into a single large tooth• Count teeth – one is missing
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Gemination
• Duplication of tooth germ into a single large tooth
• Count teeth – none are missing
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Concrescence
• Fusion of cementum between contiguous teeth
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Congenital Syphilis
HUTCHINSON’S TEETHMulberry Molars
Notched incisors
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Mulberry Molars, congential syphilis
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Alterations in Number• Decreased numbers
– Partial Anodontia• 2nd bicuspid/3rd molar agenesis,
autosomel dominant, MSXI gene mutation
– Oligodontia– Anodontia– Hereditary Ectodermal Dysplasia– Ellis-van Crevald Syndrome– Incontinentia pigmenti
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Partial Anodontia
Mandibular centrals
2nd premolar/3rd molarAgenesis
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Hereditary Ectodermal Dysplasia• Inherited as an X-linked recessive, confined to
males. Heterozygotes may show mild manifestations. Rare forms are autosomal recessive.
• Mutation in ED1 gene that encodes ectodysplasin-A (EDA), a tumor necrosis factor family protein
• Anodontia, partial vrs complete• Conical crowns• Anhidrosis, heat intolerant (eccrine agenesis• Lanugo hair• Frontal bossing, saddle nose
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Hereditary Ectodermal Dysplasia
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HED
Lanugo Hair
Complete Anodontia
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Incontinentia Pigmenti
• Skin and oral mucosal white and pigmented lesions
• Missing teeth, delayed eruption• Mutation in proteins involved with • signal transduction (NFkappaB)
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Alterations in Number
• Increased Numbers– Supernumerary Teeth
• Mesiodens• Premolars• Paramolars
– Cleidocranial Dysplasia– Gardner Syndrome
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Supernumerary Teeth
mesiodens
paramolar
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Supernumerary Teeth
Lateral Incisor
Premolar
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Cleidocranial Dysplasia
• Clavicular Agenesis• Supernumerary teeth• Multiple impactions• Cranial ossification anomalies
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Cleidocranial Dysplasia: Clavicular Agenesis
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Cleidocranial Dysplasia
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Cleidocranial Dysplasia: Dental Changes
Supernumeraty Impacted Teeth
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Gardner SyndromeAdenomatous Polyposis Syndrome
• Premalignant Colonic Polyps that transform into adenocarcinomas
• Hereditary loss or mutation of the tumor suppressor gene APC1
• Multiple osteomas of the craniofacial bones
• Multiple supernumerary impacted teeth
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Gardner Syndrome
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Tooth Wear and Loss of Structure
• Attrition• Abrasion• Erosion
– Subcervical Erosion• Enamel hypoplasia• Fracture
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Attrition
• Physiologic wear, course diet
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Abrasion
• Pathologic Tooth Wear
carpenter
toothbrush
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Erosion• Idiopathic loss of tooth structure• Defective DEJ, acidic foods, regurgitation
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Bulemia> Gastric Acid Erosion of the lingual surfaces
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Enamel Hypoplasia• Linear pitted loss of enamel
corresponding to date of precipitating event (fever).
• In today’s world, fevers are usually controlled with antipyretic analgesics; hence, hypoplastic dental changes are very rare.
• Delve into potential heritable cause – c/w pitted hypoplastic form of
amelogenesis imperfecta– Pitted enamel in Tuberous
Sclerosis• Turner’s tooth
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Turner’s ToothInfection of deciduous tooth, usually an anterior tooth,
causing damage to underlying secondary tooth
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Coronal Fracture
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Alterations in Structure• Fluorosis• Amelogenesis imperfecta• Dentinogenesis imperfecta• Dentin dysplasia• Cemental agenesis (hypophosphatasia)• Hypophosphatemia (Vit D refractory
rickets)• Regional Odontodysplasia• Internal and External Root Resortion
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Fluorosis• Fluoride ion in excess of 1 ppm in
drinking water, encountered in well water and assimilated into developing teeth.
• Mottled enamel, brown and chalky white.
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Amelogenesis Imperfecta• Various forms with differing modes of
inheritance– Specific mutations have been discovered, many
involving the amelogenin and enamelin enamel proteins
• Three major phenotypes– Hypomaturation: enamel is structurally defective and
soft, often being discolored– Hypoplastic: enamel is sound structurally, yet is thin, a
defect in quantitative synthesis– Hypocalcification: enamel matrix is formed, yet
hydroxyappatite crystal formation is defective, leaving punctate pits similar to acquired enamel hypoplasia
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Amelogenesis Imperfecta
HYPOPLASTICTYPE
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AMELOGENESIS IMPERFECTASnow Capped Teeth
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Amelogenesis ImperfectaPigmented Hypomaturation
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Amelogenesis ImperfectaHypoplastic Pitted
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Dentinogenesis Imperfecta• Dentin is defective with haphazardly arranged dentinal tubules• Autosomal dominant
– Type I: DGI1 (DI with OI) > COLIA1 and COLIA2, genes that encode the α-1 and α-2 chains of type I collagen
– Type II: DGI2 > (DI alone with mutation in dentinal sialoprotein) – Type III: DGI3 (Brandywine type) > mutations in Dentin
sialophosphoprotein gene, sialoprotein fraction (DSP)• Pulp chambers are obliterated• Spike shaped roots• Enamel is sound, yet DEJ adhesion is poor and it therefore flakes
away• Once enamel goes, the defective dentin is rapidly abraded away,
being most severe in DGI3 where pulp exposures are common• Association with osteogenesis imperfecta (DGI1)
– Multiple fractures– Blue sclera
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Dentinogenesis Imperfecta (DGI2)
“opalescent teeth”
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Dentinogenesis imperfecta
“pulpless teeth”
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Dentinogenesis Imperfecta with Osteogenesis Imperfecta (DGI1)
• Autosomal dominant heritable disease, mutations in type 1 collagen genes
• Dentinogenesis imperfecta exhibits same appearance as the uncomplicated form
• Osteogenesis imperfecta is characterized by weak fragile bones with a history of multiple fractures
• Blue Sclera• Diminutive stature• Truncated life span
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Dentinogenesis/Osteogenesis Imperfecta (DGI1)
Blue sclera
“Pulpless teeth”
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Dentin dysplasia type I• Heritable disorder involving dentin
and radicular morphogenesis• “Rootless” teeth; normal appearing
crowns• Crescent shaped pulp chambers• Microscopically, the dentin is
markedly altered with a cascade-like pattern.
• Premature tooth loss
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Dentin Dysplasia type I
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Dentin Dysplasia Type I
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Dentin Dysplasia type II• Heritable disorder involving
entire dentition• Mutation in Dentin
sialophosphoprotein, phosphoprotein fraction (DDP)
• Large pulp chambers• Large pulp stones• Thistle shaped radicular canals• Normal appearing crowns
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Dentin Dysplasia Type II
Martini glass teeth
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Cemental Agenesis• Hypophosphatasemia (Hypophosphatasia)• Autosomal recessive defect in alkaline
phosphatase, an enzyme critical for phosphorylation of osteoid matrix (1p36-p34)
• A milder autosomal dominant form also occurs
• Rachitic bone changes in children, osteomalacia in adults
• Premature exfoliation of teeth due to defective PDL-cementum adhesion
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Hypophosphatasia
Cemental agenesis
Premature exfoliation
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Vitamin D Dependent Hereditary Rickets
• Inherited as an autosomal dominant trait with inability to form 1α,25 dihydroxy-Vit D3– Type I – mutation in 1α hydroxylase– Type II – mutation in vitamin D receptor complex
• Coronal fissures in which bacteria can gain access to the pulp in the absence of carious lesions
• Periapical radiolucencies representing spread of endodontic infection
• Generalized features in common with vitamin D deficient rickets (without response to vitamin therapy)
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Coronal Fissures, Apical InfectionsVitamin D Refractory Rickets
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Regional Odontodysplasia• Sporadic• Deficient odontogenesis of all dental
hard tissues in a focal area• Usually 3-4 teeth involved• Ghost teeth of Rushton• Spheroidal calcifications seen
histologically in the dental follicles of affected areas
• Anomalous vascular tissue in region
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Ghost Teeth
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Regional Odontodysplasia
• Peridental soft tissues
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Discoloration/Pigmentation• Dental decay• Pink Tooth of Mummery (coronal internal resorption)• Pulpal necrosis • Congenital Jaundice
– Hepatitis, Biliary Atresia, Hemolytic Anemia: bilirubin pigment incorporated into developing dentin
• Fluorosis• Amelogenesis imperfecta• Dentinogenesis imperpecta• Extrinsic pigmentation
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Pigmentations
FLUOROSIS NECROTIC PULP
PINK TOOTH (INTERNAL RESORPTION) DENTINOGENESIS IMPERFECTA
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PIGMENTATIONS
TETRACYCINE AMELOGENESIS IMPERFECTA
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Delayed Eruption• Hypopituitarism• Hypothyroidism (Cretinism)• Impaction
– Third molars>cuspids– Overlying neoplasms (e.g.:
odontoma)– Cleidocranial dysplasia– Cherubism
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Impaction
Cysts
Odontomas preventing eruption
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Premature Tooth Loss
• Juvenile Periodontitis• Langerhans Cell Histiocytosis• Hypophosphatasia• Vitamin C Deficiency• Neoplasms
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Tooth Resorption
• External– Idiopathic– Post Orthodontic Therapy– Pathologic Processes– Subcervical Erosion
• Internal
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Subcervical Erosion• Idiopathic loss of enamel, cementum and dentin in the cervical region
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External Resorption
Pathologic Processes
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Incomplete Development
History of Radiation to Head and Neck