Days
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0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 0 1 2 3 4 5 6 7 20% Parent 20% shScr 20% shCBS#07 20% shCBS#61 1% Parent 1% shScr 1% shCBS#07 1% shCBS#61 Days Relative cell number 20% O 2 1% O 2 Supplementary Fig. 1
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20% O 2. Relative cell number. 1 % O 2. Days. Supplementary Fig. 1. A. B. C. Tumor Volume (mm 3 ). *. Vascular density. 25. 20. D. E. 15. 10. 5. Depth of invasion ( m m). 0. active caspase-3 positive cells / mm 2. Ki-67 positive cells (%). shNT. Parent. shCBS#07. - PowerPoint PPT Presentation
Transcript of Days
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720% Parent20% shScr20% shCBS#0720% shCBS#611% Parent1% shScr1% shCBS#071% shCBS#61
Days
Rel
ativ
e ce
ll nu
mbe
r20% O2
1% O2
Supplementary Fig. 1
Parent shNT shCBS#070
10
20
30
40
Vas
cula
r de
nsity
Tum
or V
olum
e (m
m3 )
*
0
5
10
15
20
25
Paren
t
shNT
shCBS#0
7
Parent shNT shCBS-07
0
10
20
30
40
Ki-6
7 po
sitiv
e ce
lls (
%)
Dep
th o
f inv
asio
n (m
m)
Paren
t
shNT
shCBS-0
70
100
200
300
400
A B C
D
Supplementary Fig. 2
E
Parent shNT shCBS#07
0
5
10
15
activ
e ca
spas
e-3
posi
tive
cells
/ m
m2
Paren
t
shScr
shCBS#0
7
shCBS#6
10
0.5
1
1.5
2
HIF
-2a
mR
NA
leve
ls
Supplementary Fig. 3