Days

3
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 0 1 2 3 4 5 6 7 20% Parent 20% shScr 20% shCBS#07 20% shCBS#61 1% Parent 1% shScr 1% shCBS#07 1% shCBS#61 Days Relative cell number 20% O 2 1% O 2 Supplementary Fig. 1

description

20% O 2. Relative cell number. 1 % O 2. Days. Supplementary Fig. 1. A. B. C. Tumor Volume (mm 3 ). *. Vascular density. 25. 20. D. E. 15. 10. 5. Depth of invasion ( m m). 0. active caspase-3 positive cells / mm 2. Ki-67 positive cells (%). shNT. Parent. shCBS#07. - PowerPoint PPT Presentation

Transcript of Days

Page 1: Days

0 0.5 1 1.5 2 2.5 3 3.5 4 4.50

1

2

3

4

5

6

720% Parent20% shScr20% shCBS#0720% shCBS#611% Parent1% shScr1% shCBS#071% shCBS#61

Days

Rel

ativ

e ce

ll nu

mbe

r20% O2

1% O2

Supplementary Fig. 1

Page 2: Days

Parent shNT shCBS#070

10

20

30

40

Vas

cula

r de

nsity

Tum

or V

olum

e (m

m3 )

*

0

5

10

15

20

25

Paren

t

shNT

shCBS#0

7

Parent shNT shCBS-07

0

10

20

30

40

Ki-6

7 po

sitiv

e ce

lls (

%)

Dep

th o

f inv

asio

n (m

m)

Paren

t

shNT

shCBS-0

70

100

200

300

400

A B C

D

Supplementary Fig. 2

E

Parent shNT shCBS#07

0

5

10

15

activ

e ca

spas

e-3

posi

tive

cells

/ m

m2

Page 3: Days

Paren

t

shScr

shCBS#0

7

shCBS#6

10

0.5

1

1.5

2

HIF

-2a

mR

NA

leve

ls

Supplementary Fig. 3