Cover Picture

Jos Alem�n, Bo Richter, Karl Anker Jørgensen,*

Jos Alem�n, Silvia Cabrera, Eddy Maerten, Jacob Overgaard, andKarl Anker Jørgensen*

One, but not the same describes the painting “Double Me” (Michael Kvium)depicted on the cover which shows two men who appear at first to be competing.However, on closer inspection it appears that their shoes are joined together: Arethey in fact cooperating? An analogy is drawn to two organocatalytic enantioselectivearylation reactions presented in the Communications by K. A. Jørgensen and co-workers on pages 5515 and 5520 ff. Both reactions feature quinone but follownoncovalent (left) and covalent (right) organocatalytic pathways. (Thanks to M.Kvium for permission to use the painting.)

Gold nanoparticlesIn their Essay on page 5480 ff., P. P. Edwards and J. M. Thomas demonstrate thatMichael Faraday performed experiments with gold nanoparticles already 150 yearsago. His conclusions were admirable as is shown by the presentation ofrepresentative research results.

Synthetic MethodsIn the Review on page 5488 ff., L. E. Overman and A. Steven describe thedevelopment of a toolbox of synthetic methods and their validation through the totalsynthesis of a number of structurally complex cyclotryptamine alkaloids. The mainchallenge lies in the stereoselective construction of quaternary carbon centers in closeproximity to one another.

BiomineralizationIn their Communication on page 5510 ff., T. R. Ward and co-workers show that, inthe presence of calcium ions, metal–organic protein frameworks form bundles thatserve as a template for the biomineralization of calcite.