Cosmetics and Natural Products Research Center
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Cosmetics and Natural Products Research Center (CosNat) สถานวิจัยเครื่องสําอางและผลิตภัณฑ์ธรรมชาติ Assoc. Prof. Neti Waranuch, Ph.D. Faculty of Pharmaceutical Sciences Naresuan University
Transcript of Cosmetics and Natural Products Research Center
Cosmetics and Natural Products Research Center
(CosNat)
สถานวจยเครองสาอางและผลตภณฑธรรมชาต
Assoc. Prof. Neti Waranuch, Ph.D. Faculty of Pharmaceutical Sciences
Naresuan University
Cosmetics and Natural Products Research Center
Founded in October 2003
Cosmetics and Natural Products Research Center
Cosmetics and Natural Products Research Center
Cosmetics and Natural Products Research Center
Cosmetics and Natural Products Research Center
Cosmetics and Natural Products Research Center
Researchers
• Assoc. Prof. Neti Waranuch, B.Sc.(Pharm), Ph.D. (Pharmaceutical scientist) • Assoc. Prof. Jarupa Viyoch, B.Sc.(Pharm), Ph.D. (Medico-Pharmaceutical scientist) • Assoc. Prof. Waree Tiyaboonchai, B.Sc.(Pharm), Ph.D.
(Pharmaceutical chemist) • Assoc. Prof. Tasana Pitaksuteepong, B.Sc.(Pharm), Ph.D.
(Pharmaceutical technologist) • Assoc. Prof. Kornanok Ingkaninun, B.Sc.(Pharm), Ph.D.
(Phytochemist) • Asst. Prof. Soravoot Rujivipat, B.Sc.(Pharm), Ph.D. (Pharmaceutical processing scientist)
Researchers
• Supaporn Lamlertthon, B.Sc.(Pharm), Ph.D. (Microbiologist) • Assoc. Prof. Sutatip Pongcharoen, M.D., Ph.D. (Immunologist) • Asst. Prof. Prateep Wornnissorn, M.D., Ph.D. (Dermatologist) • Panlop Chakkavittumrong, M.D. (Dermatologist) • Non Sowanna, M.D. (Family medicine doctor) • Asst. Prof. Katechan Jampachaisri, Ph.D. (Statistician)
Services
• Pharmacological Screening • Cosmetic Formulations Development • Chemical-analytical Research • Microbiology Test • Efficacy and Safety Tests • Consumer Preferences Test • Marketing Survey
Efficacy Tests
• Moisterization (Corneometer) • Transepidermal water loss (Tewameter) • Skin elasticity (Cutometer) • Skin roughness (Visiometer, Visioscan) • Skin oiliness (Sebumeter) • Skin pH measurement (Skin pH Meter) • Skin color (Maxameter)
Efficacy Tests
• Anti-perspirant (Gravimetric Test)
• Deodorant (Sniffing Test) • Home use test • etc.
Safety Tests
• Simple 48 hours patch test • Human repeated Insult patch test • Antecubital wash test • Repeated open application test • Stinging test
Involving Parties in Clinical Evaluation
Trial
Project manager Sponsor(s)
Principal investigator(s)
Site coordinator(s)
Institutional Review Board
FDA
Operator(s)
Subjects
Eight Steps in the Clinical Evaluation
Literature review
Study design
Ethic protocol submission
Volunteers selection
Placebo run-in
Panel study
Data analysis
Report
Wrinkle scales
1 2 3
4 5
16
Instruments
Cutometer for skin elasticity Tewameter for skin irritation
Instruments
Mexameter for skin darkness
Skin-pH meter, Sebumeter, Corneometer
Instruments
Rotameter for hair friction
Instron for hair tensile
Instruments
Instruments
Skin irritation test
Rodamine Red in Chitosan Microparticles
ระบบนาสง
Green Tea in Chitosan Microparticles
21.53
35.66
6.97
63.8
0
21.84
0.35 1.360
10
20
30
40
50
60
70
80
Green tea Solution Green tea loaded chitosanmicroparticle
% o
f app
lied
dose
EGC
EC
EGCG
ECG
Skin absorption
Anti-wrinkle testing
Before After
Turmeric extract in solid lipid nano-particles
Turmeric extract in solid lipid nano-particles
0
10
20
30
40
Before 1 mo ( sun) 1mo( sunprotect) 3 mo (sun) 3 mo (sun protect)
* b
Cream containing curcuminoids SLNs Curcuminoids cream
Color stability
Chemical stability Curcumin
0
20
40
60
80
100
1 mo (sun) 3mo (sun) 1 mo(sunprotect)
3 mo(sunprotect)
% c
urcu
min
cream containingcurcuminoids SLNscurcuminoids cream
Keep at room temperature
Bisdemethoxycurcumin
0
20
40
60
80
100
1 month (sun) 3 month (sun) 1 month (sunprotected)
3 month (sunprotected)
% b
isd
em
eth
oxycu
rcu
min
Demethoxycurcumin
0
20
40
60
80
100
1 month (sun) 3 month (sun) 1month (sunprotected)
3 month (sunprotected)
% d
emet
ho
xycu
rcu
min
Anti-wrinkle testing
Baseline 5 Weeks
Skin images evaluation
Baseline 8 Weeks
Skin product development
Anti-wrinkle testing
Baseline week 12
Anti-wrinkle testing
Baseline week 12
Hair product development
Baseline 4 Months
Hair growth evaluation
Hair growth evaluation
Baseline 4 Months
Under-arm product development
Baseline 11 Weeks
Hair growth suppression
Anti-cellulite product development
Anti-cellulite evaluation
Anti-cellulite evaluation
Our clients
Our clients
- บรษท ทโอลน คอสเมตค จากด
- Complexsion science - บรษท สกนเนกซ จากด
- บรษท ไบรทเซส กรป จากด - บรษท โยนโส จากด
- บรษท กรนบราเธอรส โปรดส จากด
Our clients
