ChemInform Abstract: Synthesis of Optically Active α-Bromohydrins via Reduction of...

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ChemInform 2012, 43, issue 41 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Alcohols Q 0230 DOI: 10.1002/chin.201241066 Synthesis of Optically Active α-Bromohydrins via Reduction of α-Bromoaceto- phenone Analogues Catalyzed by an Isolated Carbonyl Reductase. — A new se- lective synthesis of (S)-α-bromohydrins is presented, involving the highly stereoselec- tive (>99% e.e.) reduction of α-bromoacetophenones (I) with carbonyl reductase in a D-glucose—D-glucose dehydrogenase-based NADP regeneration system. — (REN, J.; DONG, W.; YU, B.; WU, Q.; ZHU*, D.; Tetrahedron: Asymmetry 23 (2012) 6-7, 497-500, http://dx.doi.org/10.1016/j.tetasy.2012.03.015 ; State Eng. Lab. Ind. Enzymes, Tianjin Inst. Ind. Biotechnol., Chin. Acad. Sci., Tianjin 300308, Peop. Rep. China; Eng.) — Mischke 41- 066

Transcript of ChemInform Abstract: Synthesis of Optically Active α-Bromohydrins via Reduction of...

Page 1: ChemInform Abstract: Synthesis of Optically Active α-Bromohydrins via Reduction of α-Bromoacetophenone Analogues Catalyzed by an Isolated Carbonyl Reductase.

AlcoholsQ 0230 DOI: 10.1002/chin.201241066

Synthesis of Optically Active α-Bromohydrins via Reduction of α-Bromoaceto-phenone Analogues Catalyzed by an Isolated Carbonyl Reductase. — A new se-lective synthesis of (S)-α-bromohydrins is presented, involving the highly stereoselec-tive (>99% e.e.) reduction of α-bromoacetophenones (I) with carbonyl reductase in a D-glucose—D-glucose dehydrogenase-based NADP regeneration system. — (REN, J.; DONG, W.; YU, B.; WU, Q.; ZHU*, D.; Tetrahedron: Asymmetry 23 (2012) 6-7, 497-500, http://dx.doi.org/10.1016/j.tetasy.2012.03.015 ; State Eng. Lab. Ind. Enzymes, Tianjin Inst. Ind. Biotechnol., Chin. Acad. Sci., Tianjin 300308, Peop. Rep. China; Eng.) — Mischke

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ChemInform 2012, 43, issue 41 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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