動物実験を用いた研究成果

発表論文等

（Ｈ２５年度，Ｈ２６年度，Ｈ２７年度，Ｈ２８年度，Ｈ２９年度）

Tsukamoto; Y. Katayama; C. Shinohara M, Shinohara A, Maekawa S. Miyamoto M. (2013) The small GTPase Rab5 homologue Ypt5 regulates cell morphology, sexual development, ion-stress response and vacuolar formation in fission yeast. Biochem. Biopjys. Res. Comm. 441, 867-872. Morita, M, Cerebral recovery and glial activation in a novel closed-head injury model "photo injury" Cerebral Blood Flow and Metabolism (2014), in press Kono K, Fujii H, Nakai K, Goto S, Kitazawa R, Kitazawa S, Shinohara M, Hirata M, Fukagawa M, Nishi S Anti-oxidative effect of vitamin d analog on incipient vascular lesion in non-obese type 2 diabetic rats 2013 年 Am J Nephrol 37・2 167-74 Ueki M, Ueno M, Morishita J, Maekawa N D-ribose ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice 2013 年 Tohoku J Exp Med 229・3 195-201 Yokoi N, Hoshino M, Hidaka S, Yoshida E, Beppu M, Hoshikawa R, Sudo K, Kawada A, Takagi S, Seino S A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat 2013 年 J Diabetes Res 2013・103731 9 Shima, F, and Kataoka, T Structure-based drug design of small-molecule Ras inhibitors having anti-tumor activity 2013 年 SPring-8 Research Frontiers Iwakura T, Lee SY, Miwa M, Sakai Y, Niikura T, Oe K, Matsumoto T, Kuroda R, Kurosaka M Analysis of circulating mesenchymal progenitor cells in arterial and venous blood after fracture 2013 年 6 月 J Tissue Eng Regen Med 7・6 501-4 Kureha F, Satomi-Kobayashi S, Kubo Y, Kinugasa M, Ishida T, Takai Y, Hirata KI, Rikitake Y Nectin-Like Molecule-5 Regulates Intimal Thickening After Carotid Artery Ligation in Mice 2013 年 6 月 Arterioscler Thromb Vasc Biol 33・6 1206-11 Sugiyama H, Mizutani K, Kurita S, Okimoto N, Shimono Y, Takai Y Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly 2013 年 6 月 Genes Cells 18・6 519-28 Adhim Z, Otsuki N, Kitamoto J, Morishita N, Kawabata M, Shirakawa T, Nibu K Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention against head and neck cancer-containing HPV16 cell lines 2013 年 7 月 Acta Otolaryngol 133・7 761-71 Li X, Yamagata K, Nishita M, Endo M, Arfian N, Rikitake Y, Emoto N, Hirata K, Tanaka Y, Minami Y Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis 2013 年 7 月 Genes Cells 18・7 608-19 Ueba H, Shiomi M, Brines M, Yamin M, Kobayashi T, Ako J, Momomura S, Cerami A, Kawakami M

Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin 2013 年 7 月 Mol Med 19 195-202 Kanagawa M, Yu CC, Ito C, Fukada S, Hozoji-Inada M, Chiyo T, Kuga A, Matsuo M, Sato K, Yamaguchi M, Ito T, Ohtsuka Y, Katanosaka Y, Miyagoe-Suzuki Y, Naruse K, Kobayashi K, Okada T, Takeda S, Toda T Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression 2013 年 8 月 Hum Mol Genet 22・15 3003-15 Harada R, Kawamoto T, Ueha T, Minoda M, Toda M, Onishi Y, Fukase N, Hara H, Sakai Y, Miwa M, Kuroda R, Kurosaka M, Akisue T Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells 2013 年 8 月 Exp Cell Res 319・13 1988-97 Behnsawy HM, Shigemura K, Meligy FY, Yamamichi F, Yamashita M, Haung WC, Li X, Miyake H, Tanaka K, Kawabata M, Shirakawa T, Fujisawa M Possible role of sonic hedgehog and epithelial-mesenchymal transition in renal cell cancer progression 2013 年 8 月 Korean J Urol 54・8 547-54 Purnomo E, Emoto N, Nugrahaningsih DA, Nakayama K, Yagi K, Heiden S, Nadanaka S, Kitagawa H, Hirata K Glycosaminoglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease 2013 年 8 月 J Am Heart Assoc 2・5 e000405 Yamamoto M, Iguchi G, Fukuoka H, Suda K, Bando H, Takahashi M, Nishizawa H, Seino S, Takahashi Y SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver 2013 年 9 月 Proc Natl Acad Sci U S A 110・37 14948-53 Tian H, Matsuo Y, Fukunaga A, Ono R, Nishigori C, Yodoi J Thioredoxin ameliorates cutaneous inflammation by regulating the epithelial production and release of pro-inflammatory cytokines 2013 年 9 月 Front Immunol 4 269 Komaki R, Togashi H, Takai Y Regulation of dendritic filopodial interactions by ZO-1 and implications for dendrite morphogenesis 2013 年 10 月 PLoS One 8・10 e76201 Matsui K, Oda K, Mizuta S, Ishino R, Urahama N, Hasegawa N, Roeder RG, Ito M Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter 2013 年 10 月 Biochem Biophys Res Commun 440・1 184-9 Ishino R, Minami K, Tanaka S, Nagai M, Matsui K, Hasegawa N, Roeder RG, Asano S, Ito M FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro 2013 年 10 月 Biochem Biophys Res Commun 440・1 125-31 Yamamoto H, Maruo T, Majima T, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Mandai K, Takai Y Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain 2013 年 11 月 PLoS One 8・11 e80356 Sakaguchi M, Bito T, Oda Y, Kikusawa A, Nishigori C, Munetsugu T, Yokozeki H, Itotani Y, Niguma T, Tsuruta D, Tateishi C, Ishii N, Koga H, Hashimoto T Three cases of linear IgA/IgG bullous dermatosis showing IgA and IgG reactivity with multiple antigens, particularly laminin-332 2013 年 11 月 JAMA Dermatol 149・11 1308-13

Shiomi M, Ishida T, Kobayashi T, Nitta N, Sonoda A, Yamada S, Koike T, Kuniyoshi N, Murata K, Hirata K, Ito T, Libby P Vasospasm of atherosclerotic coronary arteries precipitates acute ischemic myocardial damage in myocardial infarction-prone strain of the Watanabe heritable hyperlipidemic rabbits 2013 年 11 月 Arterioscler Thromb Vasc Biol 33・11 2518-23 Shiomi M, Koike T, Ito T Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins 2013 年 11 月 Atherosclerosis 231・1 39-47 Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, Katayama Y Osteocytes regulate primary lymphoid organs and fat metabolism 2013 年 11 月 Cell Metab 18・5 749-58 Ali H, Emoto N, Yagi K, Vignon-Zellweger N, Nakayama K, Hatakeyama K, Asada Y, Rikitake Y, Hirata K Localization and Characterization of a Novel Secreted Protein, SCUBE2, in the Development and Progression of Atherosclerosis 2013 年 11 月 Kobe J Med Sci 59・4 E122-31 Ratta-Apha W, Hishimoto A, Mouri K, Shiroiwa K, Sasada T, Yoshida M, Supriyanto I, Ueno Y, Asano M, Shirakawa O, Togashi H, Takai Y, Sora I Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain 2013 年 12 月 Neurosci Res 77・4 222-7 Harada K, Miyake H, Kusuda Y, Fujisawa M Characterization of mechanism involved in acquired resistance to sorafenib in a mouse renal cell cancer RenCa model 2013 年 12 月 Clin Transl Oncol Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N: Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells 2014 年 J Cell Sci Iwamoto N, Higashi T, Furuse M Localization of angulin-1/LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo 2014 年 1 月 Cell Struct Funct 39・1 1-8 Fukuda T, Kominami K, Wang S, Togashi H, Hirata K, Mizoguchi A, Rikitake Y, Takai Y Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities 2014 年 1 月 Development 141・2 399-409 Fujiwara S, Nagai H, Shimoura N, Oniki S, Yoshimoto T, Nishigori C Intratumoral CD4+ T Lymphodepletion Sensitizes Poorly Immunogenic Melanomas to Immunotherapy with an OX40 Agonist 2014 年 1 月 J Invest Dermatol Tsugawa H, Tsujimoto Y, Sugitate K, Sakui N, Nishiumi S, Bamba T, Fukusaki E Highly sensitive and selective analysis of widely targeted metabolomics using gas chromatography/triple-quadrupole mass spectrometry 2014 年 1 月 J Biosci Bioeng 117・1 122-8 Okada K, Miyake H, Yamaguchi K, Chiba K, Maeta K, Bilasy SE, Edamatsu H, Kataoka T, Fujisawa M Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis 2014 年 2 月 Biochem Biophys Res Commun 445・1 89-94 Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y

Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons 2014 年 2 月 PLoS One 9・2 e89763 Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S, Minami H, Azuma T, Takai Y Absence of primary cilia in cell cycle-arrested human breast cancer cells 2014 年 2 月 Genes Cells 19・2 141-52 Hatakeyama Y, Kobayashi K, Nagano T, Tamura D, Yamamoto M, Tachihara M, Kotani Y, Nishimura Y Synergistic effects of pemetrexed and amrubicin in non-small cell lung cancer cell lines: Potential for combination therapy 2014 年 2 月 Cancer Lett 343・1 74-9 Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, Matsui T Posttranscriptional Modulation of Cytokine Production in T Cells for the Regulation of Excessive Inflammation by TFL 2014 年 2 月 J Immunol 192・4 1512-24 Matsumoto Y, Kanamori A, Nakamura M, Takahashi T, Nakashima I, Negi A Sera from patients with seropositive neuromyelitis optica spectral disorders caused the degeneration of rodent optic nerve 2014 年 2 月 Exp Eye Res 119 61-9 Hirata H, Yurube T, Kakutani K, Maeno K, Takada T, Yamamoto J, Kurakawa T, Akisue T, Kuroda R, Kurosaka M, Nishida K A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype 2014 年 3 月 J Orthop Res 32・3 455-63 Yamamoto K, Nishiumi S, Yang L, Klimatcheva E, Pandina T, Takahashi S, Matsui H, Nakamura M, Zauderer M, Yoshida M, Azuma T Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection 2014 年 3 月 Mucosal Immunol Ueshima E, Yamaguchi M, Ueha T, Muradi A, Okada T, Idoguchi K, Sofue K, Akisue T, Miwa M, Fujii M, Sugimoto K Inhibition of Growth in a Rabbit VX2 Thigh Tumor Model with Intraarterial Infusion of Carbon Dioxide-Saturated Solution 2014 年 3 月 J Vasc Interv Radiol 25・3 469-76 Nugrahaningsih DA, Emoto N, Vignon-Zellweger N, Purnomo E, Yagi K, Nakayama K, Doi M, Okamura H, Hirata K Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice 2014 年 3 月 Hypertens Res 37・3 202-9 Nakai K, Fujii H, Kono K, Goto S, Kitazawa R, Kitazawa S, Hirata M, Shinohara M, Fukagawa M, Nishi S Vitamin d activates the nrf2-keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats 2014 年 4 月 Am J Hypertens 27・4 586-95 Bao W, Morimoto K, Hasegawa T, Sasaki N, Yamashita T, Hirata K, Okita Y, Okada K Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats 2014 年 4 月 J Vasc Surg 59・4 1098-108 岩佐 賢二郎, 林 申也, 藤代 高明, 神崎 至幸, 橋本 慎吾, 坂田 周平, 鎮西 伸顕, 黒田 良祐, 黒坂 昌弘

ヒト軟骨細胞において PTEN は酸化ストレス下に基質の産生を調整する 2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1321 戸田 達史 【サルコペニアとアンチエイジング】 筋肉研究の最前線 筋ジストロフィー 2013 年 8 月 アンチ・エイジング医学 9・4 号 541-547 坂田 周平, 藤代 高明, 林 申也, 神崎 至幸, 橋本 慎吾, 岩佐 賢二郎, 鎮西 伸顕, 黒田 良祐, 黒坂 昌弘 エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する 2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1322 松下 雄彦, 黒田 良祐, 松崎 時夫, 高山 孝治, 石田 一成, 佐々木 宏, 松本 知之, 藤田 周史, 長井 寛斗, 黒坂 昌弘 軟骨変性の病態 長寿因子 SIRT1 による軟骨変性と変形性関節症における役割 2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1520 松崎 時夫, 松下 雄彦, 高山 孝治, 松本 知之, 岡 真也, 長井 寛斗, 上藤 淳郎, 齊藤 高志, 田畑 泰彦, 黒田 良祐, 黒坂 昌弘 マウス変形性関節症モデルにおける徐放化 rapamycin 投与の関節症進行抑制効果 2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1605 上藤 淳郎, 松本 知之, 松下 雄彦, 川上 洋平, 岡 真也, 西澤 勇一郎, 松崎 時夫, 長井 寛斗, 黒田 良祐, 黒坂 昌弘 膝前十字靱帯由来細胞の細胞特性における年齢による差異の検討 2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1508 長井 寛斗, 松下 雄彦, 松崎 時夫, 松本 知之, 張 樹蓉, 高山 孝治, 岡 真也, 西澤 勇一郎, 上藤 淳郎, 黒田 良祐, 黒坂 昌弘 ヒト軟骨細胞における長寿遺伝子 SIRT6 による役割の検討 2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1359 佐々木 直人, 平田 健一 【制御性 T 細胞-その基礎と臨床展開】 動脈硬化症における制御性 T 細胞の役割 2013 年 9 月 医学のあゆみ 246・10 号 893-901 山下 智也, 佐々木 直人, 平田 健一 心臓と他臓器のコミュニケーションを探る 臓器関連から考える新しい循環器病治療戦略 腸管は心血管病予防の新たな治療ターゲットになる 2013 年 9 月 循環器専門医 21・2 号 291-296 Mifune Y, Matsumoto T, Murasawa S, Kawamoto A, Kuroda R, Shoji T, Kuroda T, Fukui T, Kawakami Y, Kurosaka M, Asahara T Therapeutic Superiority for Cartilage Repair by CD271 Positive Marrow Stromal Cell Transplantation 2013 年 Cell Transplant 22・7 1201-11 Kim M, Platt M, Shibasaki T, Quaggin S, Backx P, Seino S, Simpson J, Drucker D GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure 2013 年 Nat Med 20・1 123-126 Naoko Ikuta, Yukiko Uekaji, Daisuke Nakata, Keiji Terao, Seiichi Matsugo Safety evaluation of R(+)-alpha lipoic acid-gamma cyclodextrin complex 2013 年 J Biochem Pharmacol Res 1・4 212-218 Matsuoka Y, Takahashi A, Kumamoto E, Morita Y, Kutsumi H, Azuma T, Kuroda K High-resolution MR imaging of gastrointestinal tissue by intracavitary RF coil with remote tuning and matching technique for integrated MR-endoscope system 2013 年 Conf Proc IEEE Eng Med Biol Soc 2013 5706-10

Kumamoto E, Takahashi A, Matsuoka Y, Morita Y, Kutsumi H, Azuma T, Kuroda K Navigation technique for MR-endoscope system using a wireless accelerometer-based remote control device 2013 年 Conf Proc IEEE Eng Med Biol Soc 2013 5698-701 Mostaço-Guidolin LB, Ko AC, Wang F, Xiang B, Hewko M, Tian G, Major A, Shiomi M, Sowa MG Collagen morphology and texture analysis: from statistics to classification 2013 年 Sci Rep 3 2190 Kawachi E, Uehara Y, Hasegawa K, Yahiro E, Ando S, Wada Y, Yano T, Nishikawa H, Shiomi M, Miura S, Watanabe Y, Saku K Novel molecular imaging of atherosclerosis with gallium-68-labeled apolipoprotein A-I mimetic peptide and positron emission tomography 2013 年 Circ J 77・6 1482-9 Takahashi N, Nomura T, Takahara Y, Yamamoto H, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse TK, Kimura A, Matano T A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8 T-cell responses in SIVmac239 infection of Burmese rhesus macaques 2013 年 PLoS One 8・1 e54300 Mizobuchi S, Kanzaki H, Omiya H, Matsuoka Y, Obata N, Kaku R, Nakajima H, Ouchida M, Morita K Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia 2013 年 J Pain Res 6 87-94 Zen K, Guo Y, Bian Z, Lv Z, Zhu D, Ohnishi H, Matozaki T, Liu Y Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state 2013 年 Nat Commun 4 2436 Zibaei M, Sadjjadi SM, Karamian M, Uga S, Oryan A, Jahadi-Hosseini SH A comparative histopathology, serology and molecular study, on experimental ocular toxocariasis by Toxocara cati in Mongolian gerbils and Wistar rats 2013 年 Biomed Res Int 2013 109580 Miyamoto Y, Uga H, Tanaka S, Kadowaki M, Ikeda M, Saegusa J, Morinobu A, Kumagai S, Kurata H Podoplanin is an inflammatory protein upregulated in Th17 cells in SKG arthritic joints 2013 年 6 月 Mol Immunol 54・2 199-207 Lim SH, Lee S, Noda K, Kawamura T, Tanaka Y, Shigemura N, Nakao A, Toyoda Y Adenosine injection prior to cardioplegia enhances preservation of senescent hearts in rat heterotopic heart transplantation 2013 年 6 月 Eur J Cardiothorac Surg 43・6 1202-8 Katsuta H, Fukushima Y, Maruyama K, Hirashima M, Nishida K, Nishikawa S, Uemura A EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries 2013 年 6 月 Invest Ophthalmol Vis Sci 54・6 4102-8 Majima T, Takeuchi K, Sano K, Hirashima M, Zankov DP, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ogita H An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo 2013 年 6 月 PLoS One 8・6 e68134 Cheng Y, Kawamura K, Takae S, Deguchi M, Yang Q, Kuo C, Hsueh AJ Oocyte-derived R-spondin2 promotes ovarian follicle development 2013 年 6 月 FASEB J 27・6 2175-84

Maeki T, Hayashi M, Kawabata A, Tang H, Yamanishi K, Mori Y Identification of the human herpesvirus 6A gQ1 domain essential for its functional conformation 2013 年 6 月 J Virol 87・12 7054-63 Asada N, Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells 2013 年 6 月 Cell Stem Cell 12・6 737-47 Terada S, Ota S, Kobayashi M, Kobayashi T, Mifune Y, Takayama K, Witt M, Vadalà G, Oyster N, Otsuka T, Fu FH, Huard J Use of an antifibrotic agent improves the effect of platelet-rich plasma on muscle healing after injury 2013 年 6 月 J Bone Joint Surg Am 95・11 980-8 Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer 2013 年 6 月 Cell Metab 17・6 1000-8 Haredy AM, Takenaka N, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Yamanishi K, Okamoto S An MDCK cell culture-derived formalin-inactivated influenza virus whole-virion vaccine from an influenza virus library confers cross-protective immunity by intranasal administration in mice 2013 年 7 月 Clin Vaccine Immunol 20・7 998-1007 Mifune Y, Matsumoto T, Takayama K, Terada S, Sekiya N, Kuroda R, Kurosaka M, Fu FH, Huard J Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34 cell sheets for ACL reconstruction 2013 年 7 月 Biomaterials 34・22 5476-87 Popiel HA, Takeuchi T, Burke JR, Strittmatter WJ, Toda T, Wada K, Nagai Y Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases 2013 年 7 月 Neurotherapeutics 10・3 440-6 Sekiguchi M, Katayama S, Hatano N, Shigeri Y, Sueyoshi N, Kameshita I Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder 2013 年 7 月 Arch Biochem Biophys 535・2 257-67 Ishida T, Miki I, Tanahashi T, Yagi S, Kondo Y, Inoue J, Kawauchi S, Nishiumi S, Yoshida M, Maeda H, Tode C, Takeuchi A, Nakayama H, Azuma T, Mizuno S Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice 2013 年 8 月 Eur J Pharmacol 714・41642 125-31 Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Kuroda R, Akimaru H, Mifune Y, Shoji T, Fukui T, Asahi M, Kurosaka M, Asahara T A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization 2013 年 9 月 Lab Invest 93・9 1036-53 Takahashi S, Tomioka M, Hiromura K, Sakairi T, Hamatani H, Watanabe M, Ikeuchi H, Kaneko Y, Maeshima A, Aoki T, Ohnishi H, Matozaki T, Nojima Y SIRPα signaling regulates podocyte structure and function 2013 年 9 月 Am J Physiol Renal Physiol 305・6 F861-70 Yamamoto K, Tsuzuki S, Minami Y, Yamamoto Y, Abe A, Ohshima K, Seto M, Naoe T

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大輔, 持田 讓治, 舛田 浩一, 森田 有亮, 黒坂 昌弘 椎間板変性と臨床 未来への展望 椎間板変性の発生機序と臨床との関連について 2015 年 9 月 日本整形外科学会雑誌 89・9 号 579-584 北岡 志保, 古屋敷 智之 【脂質疾患学 なぜあぶらの異常が病気を引き起こすのか?その質的量的変化と肥満、がん、不妊症、免疫・皮膚・神経疾患】 (第 2 章)多彩な疾患における脂質の量的・質的変化 神経疾患 ドパミン依存的な情動行動における PGE2-EP1 経路の役割と精神疾患との関連 2015 年 9 月 実験医学 33・15 号 2468-2473 向山 順子, 下野 洋平, 船越 洋平, 河野 誠之, 山下 公大, 向原 徹, 高尾 信太郎, 南 博信, 掛地 吉弘 NK 細胞浸潤がヒト乳がん異種移植マウスの腫瘍増殖に与える影響 2015 年 10 月 癌と化学療法 42・10 号 1252-1255 江本 拓央, 山下 智也, 平田 健一 腸内細菌と循環器疾患 2015 年 10 月 臨床化学 44・4 282-289 淀井 景子, 山下 智也, 河野 浩之, 佐々木 直人, 北 智之, 笠原 和之, 佐々木 義浩, 松本 卓也, 江本 拓央, 溝口 泰司, 林 友鴻, 平田 健一 ンジオテンシン II 誘発性大動脈瘤形成に対する n-3 系多価不飽和脂肪酸 EPA と DHA の差異の検討 2015 年 10 月 薬理と治療 43・10 1409-1416 Fukuda I, Nishiumi S, Mukai R, Yoshida KI, Ashida H Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers 2015 年 Int J Food Sci Nutr Takamatsu Y, Hagino Y, Sato A, Takahashi T, Nagasawa SY, Kubo Y, Mizuguchi M, Uhl GR, Sora I, Ikeda K Improvement of learning and increase in dopamine level in the frontal cortex by methylphenidate in mice lacking dopamine transporter 2015 年 Curr Mol Med 15・3 245-52 Kasahara Y, Arime Y, Hall FS, Uhl GR, Sora I Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice 2015 年 Curr Mol Med 15・3 237-44 Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study 2015 年 Curr Mol Med 15・3 265-74 Ueda S, Kokaji Y, Simizu S, Honda K, Yoshino K, Kamisoyama H, Shirai Y, Yamanoue M Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle 2015 年 Biosci Biotechnol Biochem 79・11 1867-75 Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes 2015 年 Metabolomics 11・5 1277-1286 Ohbuchi K, Nishiumi S, Fujitsuka N, Hattori T, Yamamoto M, Inui A, Azuma T, Yoshida M Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma 2015 年 Evid Based Complement Alternat Med 2015 871832 Gheni G, Yokoi N, Beppu M, Yamaguchi T, Hidaka S, Kawabata A, Hoshino Y, Hoshino M, Seino S Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat

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Ibi M, Liu J, Arakawa N, Kitaoka S, Kawaji A, Matsuda KI, Iwata K, Matsumoto M, Katsuyama M, Zhu K, Teramukai S, Furuyashiki T, Yabe-Nishimura C Depressive-like behaviors are regulated by NOX1/NADPH oxidase by redox modification of NMDA receptor 1 2017 年 3 月 J Neurosci 横井 伯英, 清野 進 【インクレチン-最近の話題】 膵β細胞に対するインクレチン作用に関する新たな知見 2016 年 6 月 BIO Clinica 31・7 号 687-691 秋末 敏宏, 河本 旭哉, 原 仁美, 深瀬 直政, 上羽 岳志, 酒井 良忠 最新基礎科学 知っておきたい 二酸化炭素の経皮吸収による悪性腫瘍の抗腫瘍効果 2016 年 7 月 臨床整形外科 51・7 号 644-646 大塚 郁夫, 菱本 明豊, 朴 秀賢, 岡崎 賢志, 毛利 健太朗, 曽良 一郎 ニコチン依存における CDH13 の役割 マウス神経前駆細胞と統合失調症臨床サンプルを用いた解析(Possible role of CDH13 in nicotine dependence: Investigations on mouse neural progenitors and schizophrenia patients)(英語) 2016 年 7 月 日本神経精神薬理学会年会プログラム・抄録集 46 回 220 森田 圭紀, 東 健 【消化器治療・最前線】 CO2 レーザーの大腸 ESD への応用 2016 年 7 月 Medical Photonics 22 号 29-34 横井 伯英 【糖尿病の遺伝素因の解明研究】 多遺伝子型(polygenic)糖尿病の解析 モデル動物を用いた 1 型糖尿病の解析 2016 年 8 月 Diabetes Frontier 27・4 号 484-487 小林 千浩, 戸田 達史 【筋ジストロフィー・筋疾患-最近の進歩】 ミオパチーの臨床と研究の最新トピックス 福山型筋ジストロフィーと類縁疾患 リビトールリン酸とアンチセンス核酸 2016 年 10 月 医学のあゆみ 259・1 号 51-57 美舩 泰, 乾 淳幸, 坂田 亮介, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史, 国分 毅 高齢ラットにおける腱板組織への糖化最終生成物沈着の検討 2016 年 10 月 肩関節 40・2 号 476-480 西海 信, 東 健, 吉田 優 医と食 2017 年 2 月 特集「オミックスと栄養学のパラダイムチェンジ」 メタボローム最新の話題-腸疾患に対するメタボローム. 9・1 18-21 Haba D, Minami C, Miyagawa M, Arakawa T*, Miki A (2017) Morphological study on the pressure ulcer-like dermal lesions formed in the rat heel skin after transection of the sciatic nerves. Acta Histochem, 119(1): 39-47. S. Tanaka, A. Maekawa, L. Matsubara, A. Imanishi, M. Yano, R.G. Roeder, N. Hasegawa, S. Asano, M. Ito Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro. 2016 年 9 月 Biochem. Biophys. Res. Commun. 478, 1706-1712, 2016. Sakai M, Tsujimura T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M. The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch. Nat Commun 7:13147, 2016 Watanabe H, Inaba Y, Kimura K, Asahara S, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H. Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-induced, Non-alcoholic Fatty Liver Disease. J Nutr 147:52-60, 2017

Kohei Tanaka, Minoru Tanaka, Junya Takegaki, Hidemi Fujinoa Preventive effects of electrical stimulation on inflammation-induced muscle mitochondrial dysfunction 2016 年６月 Acta Histochemica,volume118, Issue5, Pages 464-470 M. Tanaka, K. Tanaka, J. Takegaki, H. Fujinoa Preventive effects of kilohertz frequency electrical stimulation on sepsis-induced muscle atrophy 2016 年 6 月 Journal of Musculoskeletal and Neuronal Interactions, volume16, Issue1, Pages 152-60 Toshiyuki Maezawa, Masayuki Tanaka, Miho Kanazashi, Noriaki Maeshige, Hiroyo Kondo, Akihiko Ishihara, Hidemi Fujino Astaxanthin supplementation attenuates immobilization-induced skeletal muscle fibrosis via suppression of oxidative stress 2016 年 9 月 The Journal of Physiological Sciences, volume67, Issue5, Pages 603-611 Uchida K, Tanaka M, Kondo H, Ishihara A, Fujino H. L-arginine supplementation attenuates capillary regression without increasing integrated succinate dehydrogenase activity and VEGF expression in skeletal muscle during hindlimb unloading 2016 年 10 月 General Physiology and Biophysics, volume35, Issue4, Pages 425-432 Ryosuke Nakanishi , Yusuke Hirayama, Minoru Tanaka, Noriaki Maeshige, Hiroyo Kondo, Akihiko Ishihara, Roland R. Roy, Hidemi Fujino Nucleoprotein supplementation enhances the recovery of rat soleus mass with reloading after hindlimb unloading–induced atrophy via myonuclei accretion and increased protein synthesis 2016 年 12 月 Nutrition Research, volume36, Issue12, Pages 1335-1344 Yusuke Hirayama, Ryosuke Nakanishi, Noriaki Maeshige, Hidemi Fujino Preventive effects of nucleoprotein supplementation combined with intermittent loading on capillary regression induced by hindlimb unloading in rat soleus muscle 2017 年 2 月 Physiological Reports, volume5, Issue4, Pages e13134 Hirayama Y, Nakanishi R, Tategaki A, Maeshige N, Kondo H, Ishihara A, Roy RR, Fujino H. Enterococcus faecium strain R30 increases red blood cell velocity and prevents capillary regression in the soleus of hindlimb-unloaded rats via the eNOS/VEGF pathway 2017 年 3 月 Microcirculation, volume24, Issue4, Pages e12356 Shimizu K, Nishiyama T, Hori Y. Gemcitabine enhances Kras-MEK-induced matrix metalloproteinase-10 expression via histone acetylation in gemcitabine-resistant pancreatic tumor-initiating cells. 2017.2 Pancreas 46: 268-275 (2017) Mukumoto N, Nakayama M, Akasaka H, Shimizu Y, Osuga S, Miyawaki D, Yoshida K, Ejima Y, Miura Y, Umetani K, Kondoh T, Sasaki R Sparing of tissue minimizes neurotoxicity when using micro-slit beam versus broad beam radiation therapy 2017 年 1 月 Journal of Radiation Research Vol. 58, No. 1, pp. 17–23 Journal of surgical research 212, 22-32, 2017 A lard-rich high-fat diet increases hepatic peroxisome proliferator-activated receptors in endotoxemic rats. Kai M, Miyoshi M, Fujiwara M, Nishiyama Y, Inoue T, Maeshige N, Hamada Y, Usami M. Sakitani N, Iwasawa H, Nomura M, Miura Y, Kuroki H, Ozawa J, Moriyama H. Mechanical stress by spasticity accelerates fracture healing after spinal cord injury. in press Calcified Tissue International Nomura M, Sakitani N, Iwasawa H, Kohara Y, Takano S, Wakimoto Y, Kuroki H, Moriyama H. Thinning of articular cartilage after joint unloading or immobilization. An experimental investigation of the pathogenesis in mice. 2017 年 5 月 Osteoarthritis and Cartilage 25(5): 727–36.

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Takaoki Saneyasu, Nami Tsuchii, Yuma Nakano, Ayana Kitashiro, Tatsuya Tsuchihashi, Haruka Shindo, Kazuhisa Honda, Hiroshi Kamisoyama. Domestic Animal Endocrinology 61, 54-61 2017/10 The IGF-1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching. Takaoki Saneyasu, Tatsuya Tsuchihashi, Ayana Kitashiro, Nami Tsuchii, Sayaka Kimura, Kazuhisa Honda, Hiroshi Kamisoyama. Animal Science Journal, in press 2017 The IGF-1/Akt/S6 signaling pathway is age-dependently downregulated in chicken breast muscle. Takaoki Saneyasu, Mariko Inui, Sayaka Kimura, Yu Yoshimoto, Nami Tsuchii, Haruka Shindo, Kazuhisa Honda, Hiroshi Kamisoyama. The Journal of Poultry Science 53, 213-219 2016/07 Hayashi D, Yagi K , Song C, Ueda S, Yamanoue M, Topham M, Suzaki T, Saito N, Emoto N, Shirai Y. (2017) Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice. Sci Rep. 7, 2597-2604. Mitani T, Yoshioka Y, Furuyashiki T, Yamashita Y, Shirai Y, Ashida H. (2016) Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress. Free Radic Biol Med. 106, 355–367. Takashi Kuwata, Takashi Hashimoto, Nobuaki Ohto, Hiroshige Kuwahara, Jae Won Lee, Takeshi Bamba, Masashi Mizuno A metabolite of dietary glucosylceramide from pineapples improves the skin barrier function in hairless mice 2017 年 3 月 Journal of Functional Foods, 30, 228-236 Sae Yamashita, Yuki Yokoyama, Hashimoto Takashi, Masashi Mizuno A novel in vitro co-culture model comprised of Caco-2/RBL-2H3 cells to evaluate anti-allergic effects of food factors through the intestine 2016 年 8 月 Journal of Immunological Methods, 435, 1-6 OGURA Yukari,TAKAGISHI Yuki, HARAYAMA Hiroshi Changes in the distribution and molecular mass of boar sperm acrosome-associated 1 proteins during the acrosome reaction; their validity as indicators for occurrence of the true acrosome reaction 2016/09 Animal Reproduction Science 172 (1) :94-104 星 信彦（2017）：第 9 章 リンパ器官 pp.125-132（担当：リンパ組織，胸腺，リンパ節），日本獣医解剖学会（編），獣医組織学 改訂第 7 版，学窓社，東京． Yanai S, Hirano T, Omotehara T, Takada T, Yoneda N, Kubota N, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. Prenatal and early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile male mice. J Vet Med Sci. 79(7): 1196-1203, 2017. doi: 10.1292/jvms.17-0154. Epub 2017 Jun 3. Omotehara T, Minami K, Mantani Y, Umemura Y, Nishida M, Hirano T, Yoshioka H, Kitagawa H, Yokoyama T, Hoshi N (2016): Contribution of the coelomic epithelial cells specific to the left testis in the chicken embryo. Developmental Dynamics, 246: 148-156. Yuasa H, Mantani Y, Masuda N, Nishida M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H (2017): Differential expression of Toll-like receptor-2, -4 and -9 in follicle-associated epithelium from epithelia of both follicle-associated intestinal villi and ordinary intestinal villi in rat Peyer’s patches. The Journal of Veterinary Medical Science, 78, 1797-1804. 石庭寛子，十川和博，安元研一，星信彦，関島恒夫 (2016): ダイオキシン汚染がアカネズミ個体群に及ぼす影響: 遺伝子マーカーを用いて個体群の反応を捉える試み．（特集１ 生態系における汚染の動態と影響）日本

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