Astore Easo SBT ekipazio berria 2013-2014 denboraldia Temporada 2013-2014.
BIOELECTRO- MAGNETISMlehre-svn.emsp.tu-berlin.de/Evicab/astore/06malmi/book/demo.pdf · BIOELECTRO-...
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BIOELECTRO BIOELECTRO - - MAGNETISM MAGNETISM Jaakko Malmivuo Demo Slides BIOELECTROMAGNETISM BIOELECTROMAGNETISM TAMPERE UNIVERSITY OF TECHNOLOGY TAMPERE UNIVERSITY OF TECHNOLOGY
Transcript of BIOELECTRO- MAGNETISMlehre-svn.emsp.tu-berlin.de/Evicab/astore/06malmi/book/demo.pdf · BIOELECTRO-...
BIOELECTROBIOELECTRO-- MAGNETISMMAGNETISM
Jaakko Malmivuo
Demo Slides
BIOELECTROMAGNETISMBIOELECTROMAGNETISMTAMPERE UNIVERSITY OF TECHNOLOGYTAMPERE UNIVERSITY OF TECHNOLOGY
AmberAmber
ηλεκτρον = amber
Hans Christian Hans Christian ÖrstedÖrsted 18191819
Magnetic needle
I
I
Battery
B
B
600
Generation of bioelectric signalGeneration of bioelectric signalVm [mV]
200 400 800 1000
-100
-50
0
50
Time [ms]
K+
Na+
K+
K+
K+
K+
K+
K+
K+
K+K+
K+
K+
K+
K+
K+ K+
K+
K+
K+
K+
K+
K+
Na+
Na+
Na+ Na+
Na+Na+
Na+
Na+
Na+
Na+ Na+
Na+
Na+ Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+K+
K+
K+
K+
K+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
Na+
K+
K+K+
K+K+
K+
K+
K+
K+
K+
K+
K+
K+
K+K+
K+K+
K+
K+
K+K+
K+K+
K+K+
Na+
Na+
Na+
Na+Na+
Na+
Na+Na+
Na+
Na+Na+
K+
Na+K+
K+
Restoring ionic balanceRestoring ionic balanceDepolarizationDepolarization RepolarizationRepolarizationNa+Na+
Na+
K+
K+
Hubert MannHubert Mann
Monocardiogram1916
RR LL
FF
L E A D 2 L E A D 3
L E A D 3
L E
A D
1
L E
A D
1
4
5
6
7
8
9
103
1
0 2
Monocardiogram1916
Hubert MannHubert Mann
Hubert MannHubert Mann
L E A D 3
L E A D 3L E A D 2
L E
A D
1
L E
A D
1
RR LL
FF
4
6
53
2
18
10
9
7
Monocardiogram1916
SquidSquid
Space clampSpace clamp
Ist = t1
x
Experimental chamberPhysiological salt solution
MembraneAxoplasm
Internal electrode
im
t = t4t = t2
t = t3
Vm is constant along the axon
Vm
A B
Φi
Φo
Vm rm
Em
cm
imimcimi
mV
secImpulses in sensory axon
Reflex ArchReflex Arch
Muscle spindle
cm
secMuscle stretch
Stretch
MuscleSpinal cord
mV
secReceptor potential in sensory terminal
mV
secSynaptic potentials in motoneuron
mV
sec
Impulses in muscle fibers
mV
sec
Impulses in motoneuron
gm
sec
Tension in muscle
0 5 10 15 25 30 35 40 45 50 55 60 6520 ms
Heart rate 1/2Heart rate 1/2NORMAL SINUS RHYTHM Impulses originate at S-A node at normal rate
All complexes normal, evenly spaced. Rate 60 – 100/min.
S-A node
SINUS BRADYCARDIA Impulses originate at S-A node at slow rate
All complexes normal, evenly spaced. Rate < 60/min.
1.0 s
1 mV
2
Jacques Fabien Gautier D’Agoty: “Anatomie des parties de la génértion de l’homme et de la femme”. Paris, 1773. Colored mezzotint. National Library of Medicine
Gautier D’Agoty’s colored mezzotints have a painterly quality. This pregnant woman calmly looks back at the viewer, a characteristic pose of 18th-century French portraiture.
The FetusThe Fetus
Fetal ECG and MCGFetal ECG and MCGVernix Caseosa: A white, cheesy waxy substance that coats the skin of a fetus in late pregnancy.Fetus body, maternal abdomen: ρ
= 5 ΩmVernix Caseosa: ρ
= 0.5 MΩm
Neighboring Method
Current flow lines Isopotential lines
V
V
V
V8
9 7
6
5
4
3
2
1 I1615
14
13
12
11
10
A
B.H. Brown and A.D. Segar, (Sheffield) 1987Current is applied through neighboring electrodes. Voltage is measured successively from all other adjacent electrode pairs. 16×13 = 208 voltage measurements, 104 independent.
89 7
6
5
4
3
211615
14
13
12
11
10
VV
V
V
I
B
![BIOELECTRO- MAGNETISM - Bioelectromagnetism · Generation of bioelectric signal V. m [mV] 200. 400. 800. 1000-100-50. 0. 50. Time [ms] K + Na + K + K + K + K + K + K + K + K + K +](https://static.fdocument.pub/doc/165x107/5ad27ef17f8b9a72118d34d0/bioelectro-magnetism-bi-of-bioelectric-signal-v-m-mv-200-400-800-1000-100-50.jpg)
