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Aulton'sPharmaceuticsThe Design and Manufacture of Medicines

Edited byM i c h a e l E . AultOriBPharmPhDFAAPSFRPharmS

THIRD EDITION

CHURCHILLLIVINGSTONE

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Contents

What is "pharmaceutics'? 1Design of dosage form s 4

12 Mixing 152\ \ t I n It, l u l l

13 Powder flow 168./ \ Sldiutuitli M I Aultmi

PART1Scientific principles of dosage formdesign 152 Dissolution and solubility 16

\l I Aitllnn3 Properties of solutions 33

U / \ultun4 Rheology 42

< MdHIUtt

5 Surface and interracia l phenomena 59./. / I'll6 Disperse systems 70

/). Atlwmul7 Kinetics of product stability 99

PART 3Pharmaceutical microbiologyand sterilization 18114 Fundamentals of microbiology 182

(,. H. lUtnlun

15 Pharm aceutical applications ofmicrobiological techniques 205.\ A Hu,l rs

16 Action of physical and chem ical agents onmicroorganisms 225(, \\ llunlun. \ .\. / / . . , / ! .: Maillanl18 Sterilization in practice 251

./>. MailUinl. S. I, Wdhh

PART 2Particle science and powdertechnology 1098 Solid-state properties 110

(/, Bin ktun9 Particle size ana lysis 121

./. ,V Stdiiitorth. M. /.. Altitun10 Pa rticle size reduction 137

./. ,V. Stdiiifurth, M. E. Altitun11 Pa rticle size separation 145./. N. Staniforth. M . E. Aulton

PART 4Biopharmaceutical principles of drugdelivery 26519 Introduction to biopharmaceutics 266

M. Ashlunl20 Gastrointestinal tract - physiologyand drug a bsorption 270

M. Ashfoni21 Bioavailability - physicochemicaland dosage form factors 286M. Ashfoni

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CONTENTS

22 Assessment of biopharmaceuticalproperties 304M. Ashtonl

23 Dosage regimens 324./. //. (ulleti

PART 5Dosage form design andmanufacture 33524 Pha rma ceutical preform ulation 336./. /. Wells. M /;. Altitun25 Solutions 361

M. K. Billanv26 Clarification 374A. M. Iw it, hell27 Suspensions and emulsions 383

M. R HilldiiY28 Powders and granules 406

M I' Summers29 Granulation 410

M. I' Summers, M. E. Aiilton30 Drying 425

M. /.. Aultnn31 Tablets and compaction 441

(/'. Alderhuni32 Mo dif ied-relea se pero ral dosage

forms 483./. H. Collclt. R. ('. Moreton33 Coating of tablets andmultipart iculates 500

S. C. Porter

34 Hard gelat in capsules 515II /.'. Junes35 Soft ge lat in capsules 527

K. (i. Hutchison, J. lerdiiidinlu36 Pulmonary drug delivery 539A. M (i. Taylor37 Nas al drug delivery 555

/ ' M Idxlur38 Transderm al drug del ivery 565

B. W. Barrx39 Wo und dressings 598

(7. M. Ea lestun40 Rectal and vaginal drug delivery 606./. ./. Tukker41 Delivery of pharm aceutical proteins 616I) . ./. A. Cruinmelln, E. vanWiiuicn. A. Mckkinti42 Packs and packaging 626/ ' M. Taylor43 Microbial con tamination, spoilage andpreservation of medicines 640

A'. A. Hud Ke\44 Product stab ility and stability testing 650

A. R. Barnes45 P h a r m a c e u t i c a l p l a n t d e s i g n 666

M. /;. Aulton, A. M. Twitehell46 H e a t t r a n s f e r and the p r o p e r t i e s and use

of steam 679/\ . M. TwitehellIndex 691