PowerPoint Presentation

The Present and Future of CXL

Rajesh K. Rajpal, MDChief Medical Officer

Founder and Medical DirectorSee Clearly Vision Group

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Financial DisclosuresAbbottAlconAllerganAvedroBausch & LombCalhounMimetogenOcular Therapeutix

OmerosPolyactivaRPSSantenShireStemnionTear SolutionsValeant

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First and Only FDA Approved Cross-Linking Now a Reality

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Reza Zadno CEORajesh K. Rajpal, MD - CMOSteven Blinn - COOMarc Friedman, PhD CSOSenior ManagementBoard of DirectorsRobert J. Palmisano Joe Mandato, PhDGil Kliman, MDJonathan SilversteinAvedro Senior Management Team

Lead Investors: InterWest and OrbiMed MA-00569A

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258,065 - 103,226 - 180,645 - 103,226 - 103,226 51,613 LASIK Vision Correction History and StatisticsLASIK StatisticsNumber of LASIK vision correction procedures performed worldwide through 2006: 24.6 million +3.7+3.5+2.8=34.6Number of LASIK vision correction procedures in the US through 2004: 10.9 million + 4.5 = 15.4 @ 2009Number of US surgeons in 2006 who performed refractive surgery: 3,762Number of excimer lasers world wide October 2006: 5,335 Number of excimer lasers US October 2006: 1,400Number of procedures referred by an optometrist 2006: approximately 207,000(Source: 2006 Market Scope Comprehensive Report in the Global Refractive Market)

MarketScope, our industry barometer, noted in its August 12, 2009 newsletter, Ophthalmic Market Perspectives, Persistently low consumer confidence and tight credit continued to severely reduce demand for refractive surgery in Q2-2009, especially when compared to a relatively robust Q2-2008. Six quarters of double-digit volume declines has begun to take a severe toll on U.S. laser vision surgery providers and led to record number of laser center closures. Although there are some signs of improvement in the economy, continuing high rates of unemployment and economic stress are expected to dampen consumer confidence and restrict demand for vision correction surgery for the balance of 2009. U.S. laser refractive procedures declined 30.8% to 192,000 in Q2-2009 when compared with 277,000 procedures in Q2-2008.

1,200,000 - 2006 1,400,000 - 20074X 277,000 = 1,100,000 - 20084 X 192,000 = 768,000 - 2009

PETTER PETTERSEN, MDThe financial crisis is just as serious in Northern Europe as it is in North America and elsewhere, but currently, our region has not seen a resulting decrease in LASIK volume. LASIK procedure volume increased steadily in Norway until 2006, and then the curve flattened. Volume has been stable for the past 3 yearsat approximately 15,000 procedures a year in our population of 4.5 million. This is roughly equivalent to the volume of LASIK in the other Nordic countries. 15,000/4,500,000 = .00333333 x 700,000,000 Europe = 2,340,000 treatments.00333333 X .05 = .00016666 X 4,700,000,000 Asia & Latin Am. = 783,000 treatmentsI practice in a chain of clinics called Memira, a major Northern European LASIK chain with 33 clinics across the Nordic countries.http://www.crstodayeurope.com/Issues/0309/0309_04.php

>140,000 crosslinking procedures performed worldwide

60 Countries covered

Avedros Approved Countries

Global PresenceUnited StatesOnly FDA approval for progressive Keratoconus and post-refractive corneal ectasiaDirect Sales and Service RepsOnly GMP riboflavin

Outside the United StatesLasik Xtra, PRK Xtra, SMILE XtraAccelerated CrosslinkingPiXL for Myopia42 International Distributors

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6 Direct Service reps7 Direct Sales Reps

PiXL The Future of Refractive CXL

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We are truly the only novel refractive procedure

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PiXL: Photorefractive Instrastromal Cross-linking

UVA patterning is applied to the center (myopia), the midperiphery (hyperopia), or a bowtie shaped region (astigmatism) of the riboflavin-soaked cornea

Goal: induce focal stiffening in the cross-linked regions, resulting in bulging of the cornea in untreated regions in response to the normal intraocular pressure

Myopia TreatmentHyperopia TreatmentMA-00569A

Cosimo Mazzotta MD, PhDDepartment of Medical Surgical and Neurosciences, Ophthalmology UnitUniversity of Siena, ItalyMA-00569A

7.6 Million 18-44 yr eyes