Amphotericin B liposomal
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Reactions 1449 - 27 Apr 2013 S Amphotericin B liposomal Various toxicities: case report A 51-year-old man with laryngeal precancerosis and laryngeal leishmaniasis experienced various toxicities while receiving amphotericin B liposomal. The man was initiated on treatment with IV amphotericin B liposomal 3 mg/kg/day. He developed severe side effects, such as elevated liver enzymes, fever, renal impairment, hypokalaemia and severe back pain resistant to paracetamol [acetaminophen]. The man’s amphotericin B liposomal was withdrawn on the fourth day. His clinical parameters normalised 10 days later. The man was resumed on amphotericin B liposomal, but back pain and fever recurred, and the drug was discontinued. Author comment: "The patient was treated with liposomal Amphotericin B (3 mg/kg/day; i.v.), but drug administration was discontinued on the fourth day because of the onset of severe side effects". Allegra E, et al. Rare association of laryngeal precancerosis and laryngeal leishmaniasis. Gazzetta Medica Italiana Archivio per le Scienze Mediche 171: 823-827, No. 6, 2012 - Italy 803086197 1 Reactions 27 Apr 2013 No. 1449 0114-9954/10/1449-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Amphotericin B liposomal
Reactions 1449 - 27 Apr 2013
SAmphotericin B liposomal
Various toxicities: case reportA 51-year-old man with laryngeal precancerosis and
laryngeal leishmaniasis experienced various toxicities whilereceiving amphotericin B liposomal. The man was initiated ontreatment with IV amphotericin B liposomal 3 mg/kg/day. Hedeveloped severe side effects, such as elevated liver enzymes,fever, renal impairment, hypokalaemia and severe back painresistant to paracetamol [acetaminophen]. The man’samphotericin B liposomal was withdrawn on the fourth day.His clinical parameters normalised 10 days later. The man wasresumed on amphotericin B liposomal, but back pain and feverrecurred, and the drug was discontinued.
Author comment: "The patient was treated with liposomalAmphotericin B (3 mg/kg/day; i.v.), but drug administrationwas discontinued on the fourth day because of the onset ofsevere side effects".Allegra E, et al. Rare association of laryngeal precancerosis and laryngealleishmaniasis. Gazzetta Medica Italiana Archivio per le Scienze Mediche 171:823-827, No. 6, 2012 - Italy 803086197
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Reactions 27 Apr 2013 No. 14490114-9954/10/1449-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
