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Alesa 2.5 gel Clindamycin 1%

Benzoyl peroxide 2.5%

Alesa 5 gel Clindamycin 1%

Benzoyl peroxide 5

Availability1 sachet

Alesa 2.5 / 5 gel

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A Additive Bactericidal with Anti-inflammatory action.

L Least Bacterial Resistance

E Efficacious for Inflammatory Acne

S

Speedy onset of action A Accuracy of dosing

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Alesa Gel

Combination gel have demonstratedefficacy through differentmechanisms of action in treatment ofacne vulgaris.

Both drugs have an antibacterial

effect, anti-inflammatory propertiesthrough different means

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Benzoyl peroxide has a mild keratolytic effect whichresults in desquamation and comedolysis

Benzoyl peroxide because of its lipophilicity is able toeasily enter and concentrate in lipid-rich pilosebaceousunits.

Moreover, the combination of benzoyl peroxide andclindamycin has been shown to reduce antibacterialresistance of P. acnes.

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Alesa Gel

Clindamycin Phosphate Clindamycin is

bacteriostatic,

(bactericidal dependingon bacterialsusceptibility &concentration of drug atsite of infection)

Inhibits proteinsynthesis

Benzoyl peroxide : Through interaction of the

oxidized intermediates ofbenzoyl peroxide with

elements of the bacterialcell.

Rapid & greater effect insuppressing P acne

compared with topicalantibiotic.

No evidence of P acneresistance to BP

A ntib acter ia l Prop er t ies

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Anti-Inflammatory PropertiesClindamycin :

Topically applied clindamycin directly reduceinflammation in acne lesions by methods other thanthrough reduction of P. acnes counts

When PMNs arrive at comedo, lysosomal hydrolyticenzymes are secreted which may contribute torupture of follicular duct.

Clindamycin has been shown to significantlysuppress complement-derived chemotaxis of PMNswith minimal effect on their random migration.

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Anti-Inflammatory PropertiesBenzoyl peroxide : Antibacterial, mildly comedolytic, and sebostatic agent. It reduces number of inflammatory lesions of acne Main effect through bactericidal means Weak anti-inflammatory properties

PMNs migrate to site of inflammation following release ofchemotactic factors by both P. acnes & host. PMNssubsequently phagocytize bacteria, during which process,oxygen is consumed and tissue-toxic reactive oxygen

species (ROS) are released enhancing inflammatorydamage.

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Anti-Inflammatory Properties

Benzoyl peroxide : Benzoyl peroxide dose-dependently inhibit

release of ROS from PMNs This inhibition elicited through drug-

induced killing of PMNs

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Indications indicated in treatment of severe

inflammatory acneDosage and Administration Apply to affected areas once or

twice daily after washing with a mildsoap, rinsing & patting skin dry

Alesa gel

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Alesa gel : Competition

Indirect :[Clindamycin]Clindac A, Solution & gel (Galderma)

Crixan gel (Crosslands)Clear gel (H & H)[Benzoyl peroxide]

Benzac AC (Galderma)