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58 Abstracts / Current Opinion in

3

SA analysis of transcranial Doppler signal using IIR fil-ers designed with ABC algorithm

urhan Karaboga 1, Fatma Latifoglu 2, Turker Koza 3

Department of Electronic Engineering, Engineering Faculty, Erciyesniversity, Kayseri 38039, TurkeyBiomedical Engineering Department, Engineering Faculty, Erciyesniversity, Kayseri 38039, TurkeyElectronic Technologies, Vocational School, Bozok University, Yozgat6200, Turkey

-mail address: turkerkoza@gmail.com (T. Koza)

In biomedical signals, noise and interference affect originalnformation signal. Noise cancellation can be carried out withnfinite impulse response (IIR) filters which have high efficiencynd shorter filter length from finite impulse response (FIR) filterypes. In this study, the noise elimination on Transcranial DopplerTCD) signals and Singular Spectrum Analysis (SSA) for healthy andatient TCD signals is proposed. Noise reduction was achieved by

IR filters, designed by the artificial bee colony (ABC) algorithmhich is a popular swarm intelligence based optimization algo-

ithm, on TCD noise signals. The noise eliminated healthy andatient TCD signal’s, data analysis was made by SSA method. Finallyew TCD signal parameters were found with SSA method for theetermination of healthy and patient subjects.

oi:10.1016/j.copbio.2011.05.159

4

stablishing cell-banks of Anatolian domestic breedsith visualization of cryostorage

atih Karakaya 1, Arzu Tas Caputcu 1, Ozlem Celasin 1, Gayeetinkaya 1, Tolga Akkoc 1, Umut Tasdemir 2, Sezen Arat 1

TUBITAK Marmara Research Center, Genetic Engineering andiotechnology Institute (MRC, GEBI), Kocaeli, TurkeyLalahan Livestock Central Research Institute (LLCRI), Ankara, Turkey

-mail address: fatih.karakaya@mam.gov.tr (F. Karakaya)

The project “In vitro Conservation and Preliminary Molecu-ar Identification of Some Turkish Domestic Animal Resources-I”imed to establish cryobanks containing somatic cell, gametes andNA samples where in both MRC, GEBI, Kocaeli and LLCRI, Ankara inonformity with FAO declarations. A fully functional and accessibleell-bank could only obtain the base material for cloning technolo-ies. For this study, a commercial cryo-container system is fullyisualized to access correctly to somatic cell vials. Visualization isesigned with photo editing software and data structure is builtith AccessTM via JET engine, both are unified over web-interface.

his visual database system is also connected to project’s wholeatabase with all bioinformatics data including GPS records. Theell-bank part of the cryostorage is so important to rescue endan-ered Anatolian domestic animals in case of extinction. The projectnd its database interface claim to supply ordered informationbout animals and its cryopreserved materials. The industry stan-

art web-based applications could help researchers to access rightaterial independent from time.

oi:10.1016/j.copbio.2011.05.160

Cccctdn

hnology 22S (2011) S15–S152

5

novel quantitative systems biology approach to canceresearch and treatment

obert Clyde 1, Hemanth Tummala 1, Hilal S Khalil 1, Katarzynaoszcz 1, Isabella Lucka 1, Maria Grazia Tupone 1, Monika Zwirek 1,aura Cavicchi 1, Jhansi Vallatur 1, Vili Stoyanova 2, Vanio Mitev 3,ikolai Zhelev 1

University of Abertay Dundee, Dundee, Scotland, UKMedical University Plovdiv, Plovdiv, BulgariaMedical University Sofia, Sofia, Bulgaria

-mail address: n.zhelev@abertay.ac.uk (N. Zhelev)

The aim of our research is to demonstrate how mathematicalnd computational modelling can be utilized for better under-tanding of the cell cycle control and cancer for benefit of a betterreatment of the disease. Our experimental work includes the quan-itative measurement of the molecules being investigated and theirctivity in live cells. We have used a novel modelling methodologyo construct a model which incorporates the activity of some 200

olecular species in a single dynamical system which can be solvedsing genetic algorithms designed to match experimental data tohe model kinetics. We have developed a methodology for unify-ng the knowledge base, particularly in relation to molecular celliology, molecular pathology, pharmacology and clinical trials. Weave illustrated the approach using breast cancer as an examplend have demonstrated its potential for the development of indi-idual patient-based models to analyse treatment protocols at theolecular level, thereby predicting drug therapies based on indi-

idual patient molecular profiles. The methodology we describes capable of absorbing a wide range of data types. It will lead toersonalised cancer models and can predict patient’s response toespective drug regimes.

oi:10.1016/j.copbio.2011.05.161

6

imulation of the chemical phase in water radiolysis withhe help of Petri nets

ana Pisakova 1, Milos Lokajicek 1, Jiri Barilla 2, Pavel Simr 2

Institute of Physics, Academy of Sciences of the Czech Republic, CzechepublicFaculty of Science, J.E. Purkinje University in Usti nad Labem, Czechepublic

-mail address: pisakova@fzu.cz (H. Pisakova)

The simulation of the chemical phase in water radiolysis maye very helpful in the study of the radiobiological effect of ion-

zing radiation when the water radicals formed by the denselyonizing ends of primary or secondary charged particle damageNA molecules in living cells. The proposed mathematical modelonsists of two main parallel processes: chemical reactions and dif-usion of radicals that have arisen in radical cluster after energyransfer. The diffusion of radicals is practically independent ofhemical reactions and depends on the diffusion coefficients only.hemical reactions depend then on radical diffusion due to thehange of radical concentration. It is possible to study the timehange of concentration of individual radicals due to their chemi-

al reactions during the diffusion process, which is important whenhe influence of different substances present in medium to the DNAamage (radiobiological effect) is to be studied. Continuous Petriet enabling to consider the role of diffusion process and chemical