2014 年 4 月 研究生读书报告
description
Transcript of 2014 年 4 月 研究生读书报告
![Page 1: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/1.jpg)
2014年 4月研究生读书报告王凯硕士研究生临床检验诊断学
![Page 2: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/2.jpg)
Seminars In Cancer Biology
A review of the current understanding and clinical utility of miRNAs in esophageal cancerComparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma
Cancer Discovery
![Page 3: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/3.jpg)
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
![Page 4: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/4.jpg)
Four miRNAs (mi-R-25, -99a, -133a and -133b) showed good potential as diagnostic markers and interestingly five (mi-R-21, -27b, -126, - 143 and -145) appeared to be useful both as diagnostic and prognostic/predictive markers.
![Page 5: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/5.jpg)
Summary of studies looking at miRNA expression in tumor tissues and non-tumor tissues
![Page 6: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/6.jpg)
Summary of miRNAs identified to have a role in determining prognosis
![Page 7: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/7.jpg)
Summary of key miRNAs identified as having a potential role in the diagnosis and/or prognosis of oesophageal cancer
![Page 8: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/8.jpg)
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
![Page 9: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/9.jpg)
11 EAC
23 fresh-frozen
primary tumors
NOTCH1 TP53 C:G>G:CA:T>C:G
Tumor Tissue EAC
12 ESCC
ESCC
![Page 10: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/10.jpg)
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
![Page 11: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/11.jpg)
Find out the drive gene
MicroRNAs matched with the drive gene
Quantitative detection of the expression of the gene and microRNA
Analyze the relationship between the expression of the gene and microRNAs
Experimental verification
![Page 12: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/12.jpg)
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
![Page 13: 2014 年 4 月 研究生读书报告](https://reader036.fdocument.pub/reader036/viewer/2022081416/568161e8550346895dd218b7/html5/thumbnails/13.jpg)
Thank You