2010 KIEC Program Book

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Governor Beshear Welcome Letter…………………………………………………………………………………….....…… i

KY CPE President Robert King Welcome Letter………………………………………………………………………….… ii

KSTC/KSEF Welcome and Overview…………………………………………….…………………………………………….. iii

Table of Contents………………………………...……………………………………………………………………………….… 1

KSTC Funding Programs and Their Socio‐Economic Impact………………………………...………………………… 3

Conference Schedule……………………………………………………………………………………………………………….. 5

Session Summaries…………………………………………………………………………………………………………………. 7

Speaker and Moderator Bios….…………………………………………………………………………………………………. 11

Poster Presenters………..…………………….……………………………………………………………………………………. 21

Poster Abstracts ……………………………..……………………………………………………………………………………… 25

Conference Attendees 55

Menu………………….…………………………………………………………………………………………………………………. 63

NOTES………………………………………………………………………………………………………………………………….. 65

Floor Plans…………………………………………………………………………………………………………………………….. 69 ON THE COVER

Image 1. The Mohan lab has discovered that the natural product withaferin A binds to the intermediate filament glial fibrillary acidic protein (GFAP) and downregulates its expression during retinal gliosis. The three dimensional model shows the 2B domain of

GFAP (four colored ribbon structures) in complex with the small molecule withaferin A (green stick figure). The background shows the staining of GFAP filaments being dismantled by withaferin A (red short structures) in the retina of mice during gliosis. Authors: Bargagna‐Mohan P, Paranthan RR, Hamza A, Dimova N, Trucchi B, Srinivasan C, Elliott GI, Zhan CG, Lau DL, Zhu H, Kasahara K, Inagaki M, Cambi F, Mohan R. Withaferin a targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. Journal of Biological Chemistry (2010). 5;285(10):7657‐69

Image 2. Assenti’s “Smart Lens”, an intraocular lens containing a MEMS sensor and an integrated circuit that can measure eye pressure sitting next to a dime. The MEMS capacitive sensor is on the left, the telemetry IC is in the middle

and 3 discrete capacitors are on the right. Author: John Naber Image credit: Assenti, 2009

Image 3. The figure shows a nanoneedle as it is being inserted into a fixed yeast cell inside SEM vacuum. NaugaNeedles Founders have developed a nanofabrication technology to grow metallic nanoneedles of silver‐gallium (Ag2Ga) at selected location and orientation. The technology was

originally developed at the University of Louisville and licensed to NaugaNeedles. Image credit: M.M. Yazdanpanah, M. Hosseini, S. Pabba, S.M. Berry, V.V. Dobrokhotov, A. Safir, R.S. Keynton, R.W. Cohn “Micro‐Wilhelmy and Related Liquid Property Measurements Using Constant Diameter Nanoneedle‐Tipped AFM Probes” Langmuir, 24, 13753‐13764 (2008)

Image 4. This illustration represents water traveling through a carbon nanotube. As water enters a carbon Nanotube it aligns along the nearly frictionless graphite sheets resulting in extremely fast wall velocities. In membranes of conventional materials, the

fluid velocity along the walls is actually zero. Authors: Majumder, M.; Chopra, N.; Hinds, B.J. Enhanced flow in carbon nanotube, Nature, 438(15), 2005, Image credit: M. Denomme, University of Kentucky

PROGRAMS:

Kentucky Science and Engineering Foundation (KSEF) builds science and engineering capacity by proactively investing in advanced and application oriented R&D, to strengthen innovative ideas and shape them in to emerging technologies for commercialization.

Kentucky Commercialization Fund (KCF) enables university faculty in commercializing the technologies developed through R&D.

Kentucky SBIR-STTR Matching Fund (KY SBIR/STTR Matching) program is designed to invest in for-profit Kentucky based companies or businesses that have been granted Small Business Innovation Research or Small Business Technology Transfer funds from any federal agency.

KSEF Funding Programs and Thei r Socio-Economic Impact

K E N T U C K Y S C I E N C E A N D T E C H N O L O G Y C O R P O R A T I O N

IMPACT: Follow On Funding: $9 in Federal and Industrial Funds for Each $1 KSEF Invested

NSF CAREER Awards: 11 KSEF Awardees Received CAREER Awards

Million Dollar Faculty: 31 KSEF Awardees Se-cured $1M or More for a Total of $50M

Academic Impact: KSEF Awardees (a Sample of the Top 16) Referenced Over 1,500 Times in the Past Five Years

Technological Innovations (KSEF & KCF):

• 92 Invention Disclosures • 49 Provisional Patents • 79 Patent Applications • 30 Issued Patents

Economic Development:

• 12 New Businesses Formed

SBIR Assistance Grants :

• ROI: 27:1

Technology Based Economic Development

Source Fol low on Funding f rom R&D Investments

Sources of Federa l SBIR-STTR Grants to Kentucky Companies

Federal$116,064,263

90%

Private $6,575,061

5%

Industrial$6,032,524

5%

Program Data Since Inception KSEF KCF KY SBIR Matching

Number of Awards 257 43 66

Funds Awarded $14,149,213 $5,554,687 $ 14,251,744 Federal Leverage Funds $ 128,671,848 Not Applicable $ 22,071,498

Return on Investment 9 : 1 New Business Creation 3 : 2

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CONFERENCE SCHEDULE

Poster Set-Up

8:00 AM - 8:45 AM

Registration, Poster Set-up and Continental Breakfast O

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8:45 AM - 9:30 AM Salon A-C

Welcome to the Sixth KIEC

Welcome, Maria Labreveux / Mahendra Jain, KSEF/KSTC Kentucky’s Big Idea, Kris Kimel, KSTC Welcome Remarks, Robert King, Council on Postsecondary Education

9:30 AM -10:15 AM Salon A-C

Session 1. Fostering an Innovation Economy

Speaker: Dan Berglund, States Science and Technology Institute Moderator: Kris Kimel, KSTC

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10:15 AM - 11:00 AM Salon A-C

Session 2. Nanotechnology: Development of Practical Systems and Commercial Applications

Speaker: Meyya Meyyappan, National Aeronautics and Space Administration Moderator: Blaine Ferrell, Western Kentucky University

11:00 to 11:45 AM – Poster Session ODD numbers / Table Top Presentations / Coffee Break

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11:45 AM - 12:30 PM Salon C

Session 3. NIH: New Application Processes and Structure

Speaker: Atul Sahai, National Institutes of Health Moderator: Nancy Martin, University of Louisville

11:45 AM - 12:30 PM Salon AB

Session 4. NSF: Priorities and Opportunities

Speaker: George Antos, National Science Foundation Moderator: Mark Crocker, University of Kentucky

12:30 PM to 1:15 PM – LUNCH (Bluegrass Pavilion)

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– 1:15 PM Bluegrass Pavilion

Session 5: Impact of State Funds on Innovation and Entrepreneurship

Part I: From Innovators at the Bench: Royce Mohan, UK; and Bruce Hinds, UK Part II: From Entrepreneurs Entering the Business World: Mehdi M. Yazdanpanah, UofL/NaugaNeedles; and John Naber, UofL/Assenti Moderator: Linda Linville, Council on Postsecondary Education

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2:15 PM Bluegrass Pavilion

Networking: The Innovation Environment

Mentorship Tables – A Place for Students to Network with Entrepreneurs Seeking Talent – Participating Companies will Post Their Current or Future Openings Networking – Spend Some Time with Program Managers, Attorneys, Innovators

2:30 PM to 3:15 PM – Poster Session EVEN numbers / Table Top Presentations / Coffee Break

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3:15 PM - 4:15 PM DarbyDan/Calumet

Session 6. Why So Few Women in STEM? - The Case of The Leaky Pipeline Speakers: Catherine Didion, The National Academies; and Nancy Martin, University of Louisville; Uschi Graham, Topasol LLC Moderator: Mary Evans Sias, Kentucky State University

3:15 PM - 4:15 PM Salon AB

Session 7. USA National Innovation Marketplace Speaker: Ken Bloemer, Eureka! Ranch International Moderator: Gary Marshall, Eastern Region ICC / Eastern Kentucky University

3:15 PM - 4:15 PM Salon C

Session 8. NIH SBIR/STTR Programs- Priorities and Opportunities Speaker: Jo Anne Goodnight, National Institutes of Health Moderator: Mahendra Jain, KSEF/KSTC

4:15 PM - 5:15 PM Salon AB

Session 9. Valuation of Technology Speaker: Michael Dansky, The Brattle Group Moderator: James Zanewicz, University of Louisville

4:30 PM to 5:15 PM – Poster Removal

SESSION SUMMARIES

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Session 1: Fostering an Innovation Economy Speaker: Dan Berglund, States Science and Technology Institute Moderator: Kris Kimel, Kentucky Science and Technology Corporation Initiatives that promote research innovations into technologies are precursors to initiatives that encourage entrepreneurship that moves the technologies to marketplace. Both initiatives are key to efforts that foster innovation economy. In the current economic situation, challenges facing scientists, innovators, technologists and entrepreneurs are many and growing. In this session, Dan Berglund, President, State Science and Technology Institute, will present the challenges that confront us and the approaches that are used by states to meet these challenges. The speaker will discuss how do we make the most significant difference for our own as well as the regional economy. Session 2: Nanotechnology – Development of Practical Systems and Commercial Applications Speaker: Meyya Meyyappan, Center for Nanotechnology, National Aeronautics and Space Administration Ames Moderator: Blaine Ferrell, Western Kentucky University There are strong nanotechnology research programs across the world in the fields of chemical sensors, biosensors, instrumentation, electromechanical devices, actuators, other nanodevices, composites, and numerous other applications. Basic discoveries have progressed at an amazing pace, as evidenced by the accumulation of publications in the literature. At present, the development of practical systems and commercial products is the next big challenge. Nanoscale is not a human scale. In many cases, development of practical systems demands seamless integration of nano‐micro‐macro scaled components and processes. While the ultimate vision in nanotechnology may be an entirely bottom‐up approach to building systems, it is unrealistic to expect this to happen anytime in the foreseeable

future. Only realistic possiblity to achieve tangible results in a reasonable time frame, before the stakeholders run out of patience, is to use nanomaterials in a hybrid approach that involves a systamatic nano‐micro‐macro integration. Such an approach will also allow us to utilize the existing infrastructure in the micro area (MEMS, microelectronics) from the last couple of decades, which would make economic sense . This talk will expand on this theme on product and system development using nanomaterials and nanotechnology. Examples will include a carbon nanotube(CNT) and nanowire based chemical sensor that has been monitoring air quality in the crew cabin in the International Space Station since January 2009 and under development for security applications; a CNT based biosensor for water quality monitoring; Bio‐field effect transistors for biomedical applications; X‐ray tubes for security and other applications; supercapacitors, and several other developments we have been working on for the last 5‐8 years. The author thanks all past and present NASA Ames colleagues for their contributions to the application development efforts, especially Jing Li, Cattien Nguyen and Michael Oye; and Prof. Jeong‐Soo Lee at POSTECH, Pohang for his contributions to Bio‐FETS. Session 3: NIH – New Application Processes and Structure Speaker: Atul Sahai, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Moderator: Nancy Martin, University of Louisville One of the priorities of the NIH Enhancing Peer Review initiative is to Improve the Quality and Transparency of Review. One of the goals associated with this priority is to shorten the Research Plan and align it with review criteria. Many of the changes to the application were made to coordinate with review criteria used by reviewers in their assessment of scientific and technical merit. The changes are centered on three priority areas: engaging the best reviewers, improving the quality and transparency of review, and ensuring balanced and fair reviews across

SESSION SUMMARIES

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scientific fields and career stages. The goal was to reduce administrative burden placed upon applicants, reviewers, and staff. In this session, Dr. Atul Sahai, Scientific Review Administrator at NIH/NIDDKD, will present and discuss how the restructured application (shortened research plan) has been aligned with review criteria in the new application and review processes. Session 4: NSF – Priorities and Opportunities Speaker: George Antos, Catalysis and Biocatalysis CBET Division, National Science Foundation Moderator: Mark Crocker, Center for Applied Energy Research, University of Kentucky The National Science Foundation is directed by Congress to utilize billions of taxpayer dollars in support of the fundamental scientific research of U.S. scientists and engineers and to educate the next generations of students to enable the continuing delivery of science and technology necessary for the fulfillment of societal needs and wants. A major current goal is to revitalize and reenergize these efforts so as to maintain U.S. leadership in the creation of new knowledge through fundamental research, with enhanced emphasis on advancing innovation to put this knowledge to work for us. Dr. George Antos will discuss broadly the NSF priorities and directions, and more specifically the opportunities and funding programs within the Engineering Directorate of NSF, in support of these goals Session 5: Impact of State Funds on Innovation and Entrepreneurship – Speakers: Royce Mohan, University of Kentucky, and Bruce Hinds University of Kentucky; Mehdi M. Yazdanpanah, University of Louisville/NaugaNeedles, and John Naber, University of Louisville/Assenti Moderator: Linda Linville, Kentucky Council on Postsecondary Education Together, KSEF and KCF have invested nearly $19.5 Million since the first awards were made in 2002. This session provides an opportunity to have a preview of

how State funds have helped our awardees. Did the funds serve as a catalyst in developing an idea, advancing the research, attracting the follow‐on funding, training graduate and undergraduate students, discovering something new, gaining recognition through publications in journals of high repute, generating intellectual property (IP), and commercializing through technology transfer or creation of a new‐ start‐up business? In other words, are these efforts producing returns on the investment (ROI)? Speakers will present on how the state funds provided by KSTC under a contract with CPE have helped them to become well known researchers and entrepreneurs. Linda Linville (Counsel for Postsecondary Education) will act as session moderator of talks presented by Royce Mohan (University of Kentucky), Bruce Hinds (University of Kentucky); John Naber (University of Louisville/Assenti), and Mehdi Yazdanpannah (University of Louisville/Nauganeedles). Session 6: Why So Few Women in STEM? ‐ The Case of The Leaky Pipeline Speakers: Catherine Didion, The National Academies, Nancy Martin, University of Louisville, and Uschi Graham Topasol LLC Moderator: Mary Evans Sias, Kentucky State University The adoption of policies and strategies to encourage girls in K through 12 to excel in Science, Technology, Engineering and Mathematics (STEM) fields has increased the numbers of women graduating with BS, MS and even PhDs in STEM fields. However, research shows that although high school girls and boys are roughly equally prepared for STEM majors, fewer girls than boys still enter college with the intention of majoring in STEM fields. Those women who do graduate with STEM BS, MS and PhDs are not proportionally represented in hierarchical academic nor entrepreneurial positions. Issues such as the rearing of children (e.g. 48% of tenure track women do not have children) or taken care of elderly parents, are common reasons why women do not undertake positions that are viewed as time

SESSION SUMMARIES

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intensive. Yet, the perception of what is female, membership in social groups, and the availability of support networks in the job may have just as much influence on a woman's decision to continue in the scientific or engineering path. Speakers in this session will present reasons why more girls don't choose scientific and technical majors and why those who do "leak" off of the scientific and entrepreneurial pipelines, why it is important to correct this problem, and what can be done about it both at the public and private sector. Session 7: USA National Innovation Marketplace Speaker: Ken Bloemer, Eureka! Ranch International Moderator: Gary Marshall, Eastern Kentucky University Business & technology Accelerator Ken will be introducing the U.S. Department of Commerce’s USA National Innovation Marketplace. The Marketplace is the most business‐friendly Open Innovation site in the world. Through a three step process of translation, valuation and access, the goal is to dramatically accelerate the rate of commercialization of new to the world innovations. The Marketplace is accessible to individuals, companies, universities and federal labs. Session 8: NIH SBIR/STTR Programs: Opportunities and Priorities Speaker: Jo Anne Goodnight, National Institutes of Health Moderator: Mahendra Jain Kentucky Science and Engineering Foundation/ Kentucky Science and Technology Corporation Federal SBIR and STTR programs are highly competitive programs that encourage small businesses to explore their technological potential and, in the process, provide the incentive to profit from its commercialization. High‐risk innovative ideas tend to outcompete the research ideas that present no‐risk. This session will provide a general overview and explain the basics of the SBIR and STTR programs. The speaker, Jo Anne Goodnight, will discuss the NIH specific programs and how the

agency publicizes and manages the opportunities offered by various institutions. She will also discuss the technical assistance programs available for transitioning SBIR/STTR biomedical innovations to the marketplace. Session 9: Valuation of Technology Speaker: Michael Dansky (The Brattle Group) Moderator: James R. Zanewicz (UoL) Intellectual property (IP), whether generated by a university or a company, is considered a valuable asset. Understanding its value and the context of that value is important for university or company to effectively price and negotiate a licensing deal and for a company to raise capital. Often for small or start‐up companies, IP is the most valuable assets that the company possesses. Thus, the value of both IP and other intangible assets is important to understand the value of a company. This session will address various methods that can be used for IP valuation. The speaker, Mike Dansky who brings many years of experience in valuing the intellectual assets of companies, will lead the discussion by presenting the basis for valuing intellectual property and the connection of that value to the execution and structuring of licensing and funding transactions.

SPEAKER AND MODERATOR BIOS

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George Antos is currently the Director of the Catalysis and Biocatalysis Program in the Engineering Directorate at the National Science Foundation. This program receives 150‐200 proposals for university research funding in fundamental catalysis, biocatalysis, biomass conversion, electrocatalysis and photocatalysis each year with millions of dollars awarded annually. George joined NSF after a 33+ year career in industry with UOP LLC. This experience encompassed the research, development and commercialization of process, catalyst and material technologies for the petroleum refining and petrochemical industries. George has authored and co‐authored over 160 US patents, and has developed a large number of presentations and papers in the area. George is also an Adjunct Professor with the Chemical and Biological Engineering Department at the University of Wisconsin, Madison and is CEO of Catalyst Realizations, Inc., a consulting company. His education includes a B.S. in Chemistry from Iowa State University, and M.S. and Ph.D. degrees in Chemistry from Northwestern University. Ken Bloemer is the Executive Director of Planet Eureka!, an international network of innovation marketplaces that includes the US Department of Commerce’s official USA National Innovation Marketplace. Ken’s specific role is to increase the rate of technology commercialization from universities, federal labs, companies and independent inventors. He has a broad diversity of experience in Fortune 100 (Johnson & Johnson), business development and process improvement consulting (TechSolve), academia (University of Cincinnati), government (US Air Force) and his true passion – inventing (founder and managing partner of Bloemer, Meiser and Westerkamp, LLC). Ken is a sought after innovation speaker and has been invited guest lecturer and/or conducted innovation workshops at over 100 universities, federal labs and inventor clubs in the US, Canada & Scotland. He has a Bachelors, Masters and Ph.D. in Industrial Engineering. Dan Berglund is the President and CEO of SSTI, a non‐profit organization that leads, supports, and

strengthens efforts to improve state and regional economies through science, technology, and innovation. SSTI is the most comprehensive resource available for those involved in technology‐based economic development. Leading SSTI since its inception in 1996, Mr. Berglund has helped SSTI develop a nationwide network of practitioners and policymakers dedicated to improving the economy through science and technology. SSTI works with this network to assist states and communities as they build tech‐based economies, conduct research on best practices and trends in tech‐based economic development, and encourage cooperation among and between state and federal programs. Prior to joining SSTI, Mr. Berglund worked as a consultant and for the Ohio Department of Development in a variety of positions, including Acting Deputy Director of the Division of Technological Innovation. Mr. Berglund holds a B.A. in Economics and Political Science and a B.A. in History from Ohio University. Mark Crocker received his BSc and Ph.D. degrees in chemistry from the University of Bristol in the United Kingdom, and subsequently spent two years as a NATO Research Fellow in the group of Prof. Charles P. Casey at the University of Wisconsin‐Madison. Thereafter he spent 15 years working in industry for first Shell Research and then as R&D Manager for Degussa’s automotive catalyst division. He is currently a Senior Scientist at the University of Kentucky Center for Applied Energy Research where his research interests include environmental catalysis and bio‐fuels. Michael J. Dansky is a Principal at The Brattle Group. For more than 25 years Mike has been focused on assisting companies in assessing, valuing, managing and licensing intellectual property assets. As a corporate executive and in his consulting career, Mike has both managed and provided expert services in a wide range of technology related matters involving patents, copyrights, trade secrets, trademarks and other intangible assets. He has structured and negotiated a wide range of transactions throughout the world including company and asset purchases and sales, technology licenses and joint ventures, and a range


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of financing transactions. Mike has been involved in the structuring, management and execution of a number of spin‐out companies including public and private placements. Mike has also testified in Federal and State Courts and administrative agencies as an expert on a range of valuation and transactional issues. Prior to joining Brattle, Mike operated his own intellectual property consulting firm and was an Officer in a publicly traded consulting firm, assisting clients in valuing, managing and executing transactions involving a wide range of intangible and tangible assets. Mike previously held senior corporate positions with Polaroid, Xerox Corporation and Amoco Corporation and has been a partner at two other international consulting firms. At Polaroid, Mike was Vice President of Corporate Strategy and Business Development where he was responsible for technology licensing, intellectual property strategy, the management and resolution of intellectual property disputes and negotiation of major international corporate transactions with Polaroid partners. Mike had similar responsibilities during his tenure at both Xerox and Amoco, where he had corporate responsibility for intellectual property, licensing and the negotiation of major transactions. Mike was recently named by IAM Magazine as one of the world’s top Intellectual Property Strategists. Catherine ‘Kitty’ Didion is the Director of the Committee on Women in Science, Engineering, and Medicine (CWSEM) of the National Academies. The mission of CWSEM is to serve as a resource for organizations and individuals seeking information and analysis about the status of women in science and engineering as well as an institutional focal point on women in science, engineering and medicine for the National Academy of Sciences (NAS), the National Academy of Engineering (NAE), and the Institute of Medicine (IOM). In addition to her work for CWSEM, she is a Senior Program Officer at the National Academy of Engineering (NAE). Her charge there is to provide staff leadership to the Academy’s efforts to enhance the diversity of the engineering workforce at all levels. As part of her responsibilities she is the Project Director for the $2.5 million Engineering

Equity Extension Service Project (EEES) which is working with engineering societies to enhance their gender equity principles within their programs. Before joining the National Academies, Catherine Didion was Vice President of the Didion Group, a public affairs and communications firm, as well as a director of the International Network of Women in Engineering and Science (INWES). Catherine Didion previously served 14 years as the Executive Director of the Association for Women in Science (AWIS). During her tenure AWIS was awarded the U.S. Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring and she was the principle investigator for 17 U.S. government and foundation grants. Catherine Didion has presented testimony before the United States Congress and U.S. federal agencies. Catherine Didion is an internationally recognized expert on issues of equity and gender in science and engineering. She has worked extensively with the European Commission, the South African Ministry of Science and Technology, the Organization of American States, and many other organizations on these issues. She has been an invited speaker on mentoring, networking, and women in science and engineering at over 200 conferences and has authored over fifty publications on women in science and engineering. She was the editor for Women in Science Column for the Journal of College Science Teaching from 1993‐2002. Catherine Didion has extensive experience on Capitol Hill in Washington, DC including staff positions at the U.S. Senate Commerce, Science, and Transportation Committee, Office of Senator Robert Packwood (R‐Oregon), the U.S. Senate Computer Center, and the U.S. Senate Press Gallery. Catherine Didion’s honors and awards include AAAS Fellow (2005); AWIS Fellow (2001); Drucker Foundation Fellow (2000); Texaco Management Institute Fellow (1999); Secretary of the U.S. Air Force Inaugural Environmental Civic Leaders Tour (1996); and Certificate of Commendation and Distinguished Service, Embassy of the United States of America (1989). Blaine Ferrell, Ph.D. is Dean of Ogden College of Science and Engineering at Western Kentucky University, Director of the Applied Research and


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Technology Program of Distinction (ARTP), and a Board Member of the Kentucky Science and Engineering Foundation in addition to other state boards. The ARTP program has faculty and students working in interdisciplinary teams to help constituents meet applied research and technical challenges. The ARTP has worked as a research development catalyst with high‐level companies in the Central Regional Innovation and Commercialization Center at the WKU R&D Center to expand existing companies and create new ones. These partnerships have created many more applied research projects for our students. Jo Anne Goodnight became the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Program Coordinator of the National Institutes of Health (NIH) and the Department of Health and Human Services (DHHS) Public Health Service in March 1999. She also serves as the Director for the Division of Special Programs in the Office of Extramural Research (OER). Most recently, she served on a seven‐month detail to the U.S. Senate Committee on Small Business and Entrepreneurship under Senator Olympia J. Snowe, where she served as a subject matter expert on issues relating to the reauthorization of the SBIR/STTR programs and other science and technology legislative issues. Ms. Goodnight has more than 25 years of Government service. She has held positions in the U.S. Department of Agriculture (USDA), the Food and Drug Administration, and now the NIH where she has been a part of the National Cancer Institute (NCI) Intramural Research Program and the NCI Extramural Research Program. As an intramural research scientist (1989–1994), she published over 20 studies about the selective involvement of Protein Kinase C in differentiation and neoplastic transformation. In 1994, she became a Program Director for SBIR/STTR grants that supported studies in the field of cancer biology, cancer genetics, and cancer immunology. She also served as the NCI’s SBIR/STTR Program Policy Coordinator and Special Assistant to the Director, Division of Cancer Biology. Ms. Goodnight leads NIH’s efforts to better manage and coordinate the NIH SBIR/STTR Programs. She was intimately involved

in the development and implementation of American Recovery and Reinvestment Act small business funding opportunities, the NIH SBIR/STTR Fast‐Track Program, SBIR/STTR Phase II Competing Renewal Awards, NIH Technical/Commercialization Assistance Programs, and the NIH Pipeline to Partnerships initiative. She continues to develop other programs that assist the small business community in commercialization of their technologies. Ms. Goodnight has been an invited speaker at hundreds of SBIR/STTR Conferences. She also has provided written and oral testimony at Congressional hearings related to the reauthorization of the SBIR and STTR Programs. Her contributions to the SBIR/STTR programs and passion for helping small businesses to be successful in these programs have been acknowledged through several national awards including NIH Director’s Awards, NIH Merit Awards, and the Small Business Administration Tibbetts Award. Ms. Goodnight received her Bachelor of Science degree in Microbiology from Virginia Tech in 1983. Go Hokies. We Will Not Forget. Uschi Graham’s primary work is directed at advancements in nano‐engineering of new materials. The work is performed at the Center for Applied Energy Research in cooperation with Argonne National Lab and the US Department of Energy. Many of the materials have significance in geological settings including nano‐clays, nano‐micas and titanium oxides as well as iron oxyhydroxides. Uschi Graham is investigating the growth and reaction mechanisms, dislocations in structurally distinct phases and polycrystalline materials. The design and synthesis of materials with nanometer dimensions (1‐10 nm) are the subject of intense current research, especially in the fields of chemical and bio‐engineering, but need also be applied to the area of geochemistry. Additional work using nano‐clays and iron oxy‐hydroxide crystals is aimed at the field of mineral kinetics (reactions taking place during diagenesis and maturation in sedimentary basins or hydrothermal mineralization involving active spreading zones). The design of hybrids or nano‐composites with intercalation of layered solids is work Uschi Graham participates in with the


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automotive and polymer industries. This type of nano‐particle research involves the formation and structural enhancements of hybrids where either two or several nanoparticles are interlaced in a polymer matrix. In collaboration with the Center for Catalysis at UK and also industrial support several studies are focused on controlling nanoparticle growth through substrate design. It is envisioned that metallocene, single site catalysts, could be incorporated into the interlayer spacing in nanoclays. The chemically functionalized templates are incorporated into structural polymeric materials to help tailor properties such as the molecular architecture, density and crystallinity of the polymer matrix while the nanoclay particles improve the mechanical, thermal and flame‐retardant properties with additions of only minute amounts of nanosized clay platelets. The nanocoposites represent a radical alternative to conventional macroscopic composites. Markedly improved mechanical and physical properties are observed. Improved strength, fire and flame resistance and also gas permeabilities of nano‐hybrid materials may in fact also be important to protect, preserve, and reshape our way of thinking about geochemical processes. Other areas of my research involve fuel cells with emphasis on hydrogen production and storage. Uschi Graham is actively involved in the World Fuel Cell Council and European Fuel Cell Forum (Switzerland). Uschi Graham also serves on the National Hydrogen Association. At the Center for Applied Energy Research Uschi Graham has been involved in the organizational aspects of the International Coal Ash Utilization Symposium, a forum that addresses research and technology in the field of coal combustion by‐products. Bruce Hinds has a unique background in Chemistry and electronic device processing. Bachelor studies were in general Chemistry at Harvey Mudd College in California. His Ph.D. work was on the growth of high temperature superconductors at Northwestern University with Prof. Tobin Marks. In addition to experience with materials growth and characterization, the thesis project included inorganic compound synthesis of CVD precursors. Upon completion of the degree, he went on to

post‐doc with Gerry Lucovsky at NC State to learn about semiconductor processing and interface states in the Si/SiO2 system. After 2 years, he then had an exciting opportunity to learn about nano‐scale fabrication at the Tokyo Institute of Technology with Professor Shunri Oda. This research effort was based on memory devices that stored a single electron in a nano‐crystal of silicon. He then joined the faculty of the University of Kentucky to start a research program to bring electronics fabrication to the molecular level. Mahendra K. Jain, Ph.D. is the founding Executive Director of the Kentucky Science and Engineering Foundation (KSEF) and Vice President of the Kentucky Science and Technology Corporation (KSTC) in Lexington, Kentucky. In his present position, Dr. Jain is fostering partnerships between academic, industrial and state institutions in building and expanding Kentucky’s scientific and engineering capacity to attract external research funds from all sources, to help advance research ideas and to build a pipeline of technologies. In addition, Mahendra has proactively pursued the growth of the Federal SBIR and STTR Programs in the state through outreach and state‐funded assistance programs, was the recipient of the Tibbetts Award in 2006, and currently also serves as the Science Director for Kentucky Space. Before joining KSTC, Mahendra worked at several universities in the USA, Europe and India. He also worked at MBI International, a biotechnology R&D company in Lansing, Michigan where he was involved in technology development and transfer. After receiving his Ph.D. in microbiology in 1972, Dr. Jain received and managed research grants and contracts in several million dollars from federal, state and industrial sources. He is the author of 11 United States patents, one Canadian patent and over 120 research papers, articles and book chapters. Kris Kimel is President and a founder of the Kentucky Science and Technology Corporation (KSTC), a non‐profit company with an international reputation for designing and implementing a range of innovative initiatives. Over the 21 year life of KSTC dozens of projects have been funded by


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diverse supporters involving corporations, private foundations, state and federal governments. KSTC funds important R&D and technology commercialization projects at Kentucky universities. It also designed and manages the Kentucky Enterprise Fund (KEF)…an early‐stage venture fund which currently holds over 60 equity positions in innovation‐driven Kentucky companies. Kimel is a leader behind the vision and implementation of Kentucky Space, a nonprofit enterprise focused on the design, development and application of entrepreneurial and educational space platforms. He is also the founder of the international IdeaFestival (IF), a world‐class event that attracts leading and highly diverse thinkers from across the nation and around the globe to explore and celebrate innovation, imagination and game‐changing ideas. Robert L. King became the third president of the Kentucky Council on Postsecondary Education January 16, 2009. He previously served as president and CEO of the Arizona Community Foundation, a statewide charitable foundation with a strong focus on education, economic development, and scientific research. Mr. King is the former chancellor of the State University of New York, one of the largest comprehensive systems of universities, colleges, and community colleges in the world. Mr. King is very active in community service and has volunteered and served on numerous boards and organizations. He also has served on the White House Commission on Presidential Scholars; the Education Committee of the U.S. National Commission for the United Nations Educational, Scientific, and Cultural Organization (UNESCO); an advisor to the Middle State Commission on Higher Education regarding reauthorization of the Higher Education Act in Congress; the board of directors of the National Soccer Hall of Fame; and the board of trustees of A.T. Still University, a specialized university dedicated to training people for the health care professions, in Kirksville, Missouri, and Mesa, Arizona. Mr. King received a Bachelor of Arts degree in 1968 from Trinity College in Hartford, Connecticut and a juris doctor in 1971 from the Vanderbilt University School of Law. He is married

to Karen, his wife of 32 years, and they have four grown children. Maria Labreveux, Ph.D. joined the Kentucky Science and Technology Corporation (KSTC) in February 2007 and is the Senior Program Manager for the Kentucky Science and Engineering Foundation (KSEF). Dr. Labreveux manages the KSEF R&D and the Kentucky Commercialization Fund (KCF) programs, for which KSTC receives funding from the Commonwealth of Kentucky through a contract with the Council on Post‐Secondary Education. Maria brings research and grants management experiences from the Delaware State University where she worked as an Assistant Professor before moving to Kentucky. Maria secured over $2 million in two and half year period at DSU for her research and teaching from federal and state agencies such as the United States Department of Agriculture, National Recourses Conservation Services, the Cooperative State Research, Education and Extension Services, the National Science Foundation, and University of Delaware. Dr. Labreveux is an active member of the Early Career Professional Division of the Agronomy and Crop Science Societies of America and a contributor to the society's monthly newsletter. Maria received her Ph.D. in Agronomy‐Plant Science from The Pennsylvania State University, and her M.S. and Ag. Engineering degrees in Argentina. Linda Linville, Ph.D. has experience with funded research and programs targeting the resources of postsecondary education, and the development of academic policies fostering workforce and economic development. She is engaged with many STEM education and research initiatives in collaboration with education, government, business and industry. The Council on Postsecondary Education (CPE) is Kentucky’s coordinating organization for postsecondary and adult education, with priority attention given to advance fundamental, long‐term improvement in the quality of life of Kentucky’s citizens and economy through educational policy development, research and implementation throughout the Commonwealth of Kentucky. Dr. Linville holds a


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doctoral degree in educational psychology from the University of Kentucky. R. Gary Marshall is Executive Director of the Eastern Region Innovation and Commercialization Center (ICC), and EKU Business and Technology Accelerator. He is an experienced senior manager with a background in executive management, marketing, sales, and operations. Marshall has held positions as vice president of sales and marketing; marketing manager; quality control and project engineer; and account project manager (for KMAC, the KY‐MEP). Gary Marshall has led private company sales, product development and profit growth through three acquisitions. He has assisted over 40 companies in successful process improvement, growth and funding projects. Gary Marshall’s unique blend of technical and business expertise and experience in diverse applications including medical products, aerospace, automotive and other industries provides significant value‐added client benefit and perspective. Nancy Martin, Ph.D. received her Ph.D. in biology from Harvard University in 1975. She trained as a post doctoral fellow at the University of Chicago in the Department of Medicine and Biochemistry until 1977 when the University of Minnesota appointed her to the faculty in the Department of Biochemistry. She subsequently moved to the University of Texas Southwestern Medical School where she was promoted to Associate Professor in 1982. The University of Louisville (UofL) recruited her in 1987 to hold the rank of professor and the Preston Pope Joyes Endowed Chair in Biochemical Research. In 1994 the University of Umea awarded her an honorary M.D. Throughout her career, she has applied state of the art molecular biological techniques to make distinguished contributions in the areas of mitochondrial biogenesis, RNA enzymology and protein targeting. The National Science Foundation, American Heart Association, American Cancer Society and the National Institutes for Health (NIH) have funded her research. The NIH provided continuous, competitive funding for twenty years. She has served nationally on the Publications Committee of the American Society of Biochemistry and

Molecular Biology (ASBMB), including a term as chair, on the National Council of the ASBMB, and as a founding member of the Innovative Technology Council of the Protein Society. She has been a study section member for the Physiological Chemistry, Molecular Cytology, Genetic Basis of Disease, and Cell Biology II NIH study sections, Metabolic Regulation and Women in Science NSF review panels and the Genetics Visiting Committee. She has served as editor or executive editor for Biochemie, The Journal of Biological Chemistry and Nucleic Acids Research. She has published and lectured extensively and organized many national and international conferences. She has been elected a Fellow by the American Association for the Advancement of Science. She served as Senior Vice President for Research at the University of Louisville from 1996 to 2006 and oversaw a tremendous expansion of research infrastructure and a more than fourfold expansion of extramural funding. She implemented a number of new policies and procedures supportive of research and technology transfer, including creation of a Technology Transfer Office. In addition to her current faculty responsibilities, she serves on the ORAU board, the board of the Northern Kentucky University Research Foundation, Pradama (a biotech startup), the leadership team of the Kentucky Girls Collaborative in STEM (science, technology, engineering and math), the Kentucky state‐wide STEM taskforce and chairs the Kentucky State wide EPSCoR Committee. Meyya Meyyappan is Chief Scientist for Exploration Technology at the Center for Nanotechnology, NASA Ames Research Center in Moffett Field, CA. Until June 2006, he served as the Director of the Center for Nanotechnology as well as Senior Scientist. He is a founding member of the Interagency Working Group on Nanotechnology (IWGN) established by the Office of Science and Technology Policy (OSTP). The IWGN is responsible for putting together the National Nanotechnology Initiative. Dr. Meyyappan has authored or co‐authored over 190 articles in peer‐ reviewed journals and made over 200 Invited/Keynote/Plenary Talks in nano‐technology subjects across the world. His research interests


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include carbon nanotubes and various inorganic nanowires, their growth and characterization, and application development in chemical and biosensors, instrumentation, electronics and opto‐electronics. Dr. Meyyappan is a Fellow of the Institute of Electrical and Electronics Engineers (IEEE), the Electrochemical Society (ECS), AVS, the Materials Research Society (MRS) and the California Council of Science and Technology. In addition, he is a member of the American Society of Mechanical Engineers (ASME) and the American Institute of Chemical Engineers (AIChE). He is currently the IEEE Nanotechnology Council (NTC) Distinguished Lecturer on Nanotechnology, IEEE Electron Devices Society (EDS) Distinguished Lecturer, and was ASME's Distinguished Lecturer on Nanotechnology (2004‐2006). He served as the President of the IEEE's Nanotechnology Council in 2006‐2007. He currently serves as the Vice President of IEEE‐EDS for Educational Activities. For his contributions and leadership in nanotechnology, he has received numerous awards including: a Presidential Meritorious Award; NASA's Outstanding Leadership Medal; Arthur Flemming Award given by the Arthur Flemming Foundation and the George Washington University; IEEE Judith Resnick Award; IEEE‐USA Harry Diamond Award; AIChE Nanoscale Science and Engineering Forum Award. For his sustained contributions to nanotechnology, he was inducted into the Silicon Valley Engineering Council Hall of Fame in February 2009. For his educational contributions, he has received: Outstanding Recognition Award from the NASA Office of Education; the Engineer of the Year Award (2004) by the San Francisco Section of the American Institute of Aeronautics and Astronautics (AIAA); IEEE‐EDS Education Award; IEEE‐EAB (Educational Activities Board) Meritorious Achievement Award in Continuing Education. Royce Mohan, Ph.D. received his B.S. in Chemistry in 1984 from Loyola College, Madras (Chennai), India, his M.Sc. in 1986 in General Chemistry at the Indian Institute of Technology, Kanpur, India and his Ph.D. in 1992 in Biochemistry at Ohio State University. He subsequently held postdoctoral fellowship positions at Harvard Medical School,

Tuft University School of Medicine, and The New England Eye Center. He is the author of numerous publications, three patents, and has received over $3 million in extramural funding. He is a peer reviewer for NIH and CNR grants, and several journals such as Investigative Ophthalmology & Visual Sciences, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Journal of Cellular Physiology, etc. He is currently in the Department of Ophthalmology and Visual Sciences at the University of Kentucky. John Naber obtained his B.S. and M.Eng. in Electrical Engineering in 1983 and 1985 respectively at the University of Louisville and the Ph.D. degree in electrical engineering from Virginia Tech in 1992. Dr. Naber worked in industry as an integrated circuit designer at General Electric (Syracuse, NY) and ITT (Roanoke, VA) from 1985 through 1995. In 1995 he came to the University of Louisville as an Instructor in the Electrical and Computer Engineering Department and is currently employed in ECE as an Associate Professor and Associate Chair. Dr. Naber has been PI or Co‐PI on 29 externally funded grants over the last 8 years with a combined total income in excess of $20,000,000, including multiple Small Business Innovation Research (SBIR) grants, two KSTC Commercialization grants and two Vogt Innovation Awards. He currently supports 3 full‐time research engineers, 4 PhD students and 2 MS students. Dr. Naber has over 60 journal and conference publications in the area of integrated circuits and sensors with applications to implantable biomedical systems. He also has 6 granted patents in the US and multiple pending patents applications both domestically and internationally. Dr. Naber is founder of four active high‐tech start‐up companies that have spun out of the Speed School of Engineering, including: Assenti LLC (implantable sensing system for glaucoma), OrthoData Inc (implantable sensing system for spinal fusion), Simon Sounds (wireless temperature monitor for infants) and Ultra‐Trace Detection LLC (sensing system for explosives). Dr. Naber is a member of Tau Beta Pi and a Senior Member in the Institute of Electrical and Electronics Engineers (IEEE).


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Atul Sahai, Ph.D. received his Ph.D. degree in Biochemistry from Howard University, and completed a Postdoctoral Fellowship at the National Institutes of Health (NIH) in 1985. Since then he has held faculty positions in the Division of Nephrology at various academic institutions and was an Associate Professor at Northwestern University, Chicago. Dr. Sahai has broad‐based experience in renal research, particularly diabetic nephropathy and signaling mechanisms associated with renal tubular and mesangial cell growth and fibrosis. In addition, Dr. Sahai’s recent work involved the role of obesity and diabetes in gastrointestinal diseases, including nonalcoholic steato‐hepatitis. During his tenure in academia, Dr. Sahai’s research work was supported by funding from various agencies including American Diabetes Association. He has published numerous research articles in high quality peer‐reviewed journals and co‐authored several book chapters; served as an ad‐hoc reviewer for numerous scientific journals including Diabetes, American Journal of Physiology, Kidney International, and Hypertension; and was a member of various advisory committees including Center for Obesity Management and Prevention at the Northwestern University. Dr. Atul Sahai joined the NIDDK Review Branch as a Scientific Review Administrator in March, 2005. Mary Evans Sias, Ph.D. was named 13th President of Kentucky State University (KSU) in March 2004. She officially arrived at the University on April 28, 2004. Prior to joining the KSU family, she served as Senior Vice President for Student Affairs and External Relations for the University of Texas at Dallas and as an Associate Professor in the School of General Studies. Dr. Sias served as CEO of the YMCA of Metropolitan Dallas for thirteen years prior to going to UT Dallas. Dr. Sias feels strongly that her 25 years in higher education and public service have provided her with a diversity of experiences that allow her to bring a broad spectrum of ideas and administration strategies to the position of President of Kentucky State. Active in the community, Dr. Sias is a member of the Frankfort Chamber of Commerce, serves on the YMCA Board of Directors, the Frankfort‐Franklin

County Community Education Board, Leadership Kentucky Board of Directors, and the Frankfort‐Lexington LINKS, Inc. While in Texas, she was President of the Tejas Council of Girl Scouts, on the Salvation Army Advisory Board and Vice Chair of Richardson Regional Hospital. She also served as a Director of Oaks Bank and Trust. Dr. Sias has received numerous awards including the “She Knows Where She’s Going Award” for outstanding service to women and girls and the Outstanding Texan Award for Community Service given by the Legislature Black Caucus of the State of Texas. Women’s Enterprise magazine gave her the “Woman of Excellence Award” this year. A native of Jackson, Mississippi, Dr. Sias is a summa cum laude graduate of Tougaloo College, and earned an MBA from Abilene Christian College. Dr. Sias received her M.S. and Ph.D. degrees in Sociology from the University of Wisconsin at Madison, where she was a Ford Foundation Fellow. President Sias and her husband, Shad, have one daughter, Adrienne. Mehdi M. Yazdanpanah is the CEO‐Founder of NaugaNeedles LLC and entrepreneurial fellow of Kauffman Foundation. He holds a Ph.D. degree in electrical engineering from the University of Louisville (2006), where he studied room temperature self‐assembly of metal alloy nanostructures. During his doctoral studies, Mehdi co‐invented a procedure to selectively grow nanoneedles on AFM tips. Later on, this invention became the basis to establish NaugaNeedles in 2007. He also holds a BS degree in physics from Sharif University of Technology (1998) and MS degree in physics from Beheshti University (2001), where he designed and fabricated a scanning tunneling microscope (STM). Mehdi is the author of more than twenty peer‐reviewed journal and conference proceeding papers and the co‐inventor of three pending US patents. He received the 2008 Vogt Innovation Award, an unrestricted cash award of $120,000 awarded to NaugaNeedles. His business plan was the selected winner among fifty industrial applicants. Under Mehdi's leadership, NaugaNeedles has achieved tremendous milestones including: raising more than $800,000 in federal, state and private funding, established the NaugaNeedles' manufacturing facility capable of


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producing more than $3,000,000 worth of products per year, sold NaugaNeedles products to more than 75 customers worldwide, and expect to expand its customer base significantly in near future. Mehdi has been selected as one of 13 Entrepreneurial Fellow of Kauffman Foundation. Mehdi is the PI on 3 active and 3 pending grant proposals to further develop the NaugaNeedles' technology. In his active projects, NaugaNeedles is developing a state of the art Ultra‐Soft Atomic Force Microscope (USAFM) instrument, and a mass fabrication of high aspect ratio AFM probes with low price. These projects are important steps toward NaugaNeedles’ exponential growth. James R. Zanewicz, J.D., L.L.M. started the Office of Technology Development at the University of Louisville in December 2000, and guided the office’s development and growth into the Office of Technology Transfer. He is originally from Kentucky, where he earned a B.S. in Chemistry from Centre College. On his winding path around the USA and back to the Bluegrass State, James lived in New Orleans where he earned his J.D. from Tulane Law School; New Jersey while he was working as a chemist and a patent law clerk for Rhone‐Poulenc; Los Angeles where he handled internet, multimedia, production and intellectual property issues for the Warner Bros. daily syndicated news‐magazine EXTRA; and Urbana‐Champaign, Illinois where he first entered the exciting realm of University Technology Transfer and learned much of what he knows from Ann Hammersla and Jill Tarzian Sorensen. James is admitted to practice before both the Kentucky Bar and the U.S. Patent and Trademark Office, and authored a thesis on “Online Data Privacy in the United States: Analysis and Proposed Regulatory Scheme” as part of earning his L.L.M. in Intellectual Property and Media Issues from the University of Illinois at Urbana‐Champaign. He co‐chairs the Technology Transfer Committee for BIO, is a steering committee member of OVALS (Ohio Valley Affiliates for Life Sciences), has served on several AUTM committees and is an active member of COGR. His proudest achievement is his involvement as a disaster services volunteer for the American Red Cross.


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PRESENTER TITLE POSTER# PRESENTER TITLE POSTER#

21

ENVIRONMENTAL AND ENERGY TECHNOLOGIES

Alexander Barzilov

Experimental Testing of the Wavelet‐Based Classification Algorithm of Active/Inactive Unexploded Ordnance

6

James Polcer

Generalized Bathtub Models for Binary‐Transformed Climate Data

3

Jennifer L Burnett

Planar Fiber‐Optic Chip for Fully Guided Raman Interrogation of Molecular Adsorbates

4

Jonathan Quiton

Cyclic Recurrent Event Modeling and Application to Climate Data

2

Kyle Moss

Broadcast Methods for the Elimination of Random Anomalous Peak Loads

7

Matthew Fuller

CFD Simulation of Flatback Airfoil

8

Monica Moreno

A Study of the Reactivity and Stability in the Presence of Hydrogen of Pd Nanoparticles Coated with Mixed Monolayers of Octylamines and Hexanethiolates

1

Rutooj D. Deshpande

Nano‐Cracks Insite Micron‐Sized Eelectrode Particles Can Change The LI‐ION Transport Mechanism And Diffuse Induced Stress

5

BIOSCIENCES

Ayman S. El‐Baz

Toward Early Diagnosis of Lung Cancer

22

Ayman S. El‐Baz

Appearance Analysis for Diagnosing Malignant Lung Nodules

23

Balmiki Ray

Neuroprotective and Neuropreservative Effects of Curcumin Against Oxidative Insults in Neuronal Cultures

25

Chifu B. Huang

Dual Insulin‐stimulating and Antibacterial Activities of Mogrosides from Lo Han Kuo Fruit (Siraitia grosvenorii)

18

Christopher L. Schardl

Development and Deployment of a Nontoxic Endophyte in Tall Fescue for Forage

37

Doug Jackson

Wireless Temperature Sensing System for Children

28

Eric G. Chapman

Maximizing Collection and Minimizing Risk: Does Vacuum Suction Sampling Increase the Likelihood for Misinterpreta‐tion of Food Web Connections

38

Gautam Pangu

Fully Biodegradable Polymersome‐Encapsulated Hemoglobin as a Novel Nanoparticle‐Based Oxygen Therapeutic

39

Girish Kotwal

Nutraceutical Nano Emulsion to Deliver Antioxidants for Neurodegenerative Diseases

30

Guiliang Tang

Effective Small RNA Destruction by Short Tandem Target Mimics through the Small RNA Degrading Nucleases in Arabidopsis thaliana

13

Hieu Tran

CENTERA Bringing New Courses in Nanotechnology for High School Faculties and Students in Common wealth of Kentucky

31

Jennifer A. White

Molecular Characterization of Microbial Symbionts in Introduced Species

24

Jeremy Hornbeck

The Environment of Young Star PDS 144S

9

Jing Shi

Fast Screening Target Sites for RNAi‐Based Termite Controls

12

Julio Gutierrez

Equine Medication Regulation: Stable Isotope Internal Standards and Certified Reference Standards

29


22

Kyle Hord

Numerical Investigation of Aerodynamics of a Corrugated Airfoil

43

Kyle Schmidt

Multi‐Physics Simulation of a Coulter Counter Device

44

Lewis J. Watson

A Unique Type of Glycosylation is Essential in Cardiomyocytes During Heart Failure

10

Luke H. Bradley

Investigation of the Mitochondrial Neuroprotective Effects of Dopamine Neuron Stimulating Peptide‐11

19

Manish Kulshrestha

Identifying Native Plant Species Containing Metabolites with Novel Activity as Potential Pharmaceuticals

20

Mark K. Adams

Molecular Identification of Interaction Pathways Between Carabid Beetles and Slugs in Alfalfa

35

Matt Druen

An Intergrative Approach t to the Study of Animal Personality

40

Michael Fannon

Analysis of Binding to Vascular Walls under Flow Using a Bioreactor

11

Michael Voor

Hip Strengthening Technology for Hip Fracture Prevention

16

Michael Voor

Hydroxyapatite Cement Augmented with Xenograft Bone Improves Incorporation into Cancellous Defects

17

Michael Wilhelm

Reuse Technology at a Wastewater Treament Plant for Aquaculture

42

Nichola C. Garbett

Differential Scanning Calorimetry: A Novel Tool for Discriminating the Extent of Intraepithelial Neoplasia and Invasive Carcinoma of the Cervix

15

Noel R. Monks

Optimizing Pharmaceutically‐Valuable Metabolites in Medicinal Plant Species by Directed Evolution

21

Palaniappan Sethu

Microfluidic Cell Arrays for High‐Throughput Culture

36

Rafaela De Negri

Evaluation of Recombinant Proteins of Streptococcus equi as Vaccine Components

34

Saeed A. Jortani

A Non‐Invasive Method for Diagnosis of Obstructive Sleep Apnea

41

Sergey C. Artiushin

Comparison of tHDA and Conventional PCR for Detection of Leptospira in Horse Urine

32

Shaun K. Stinton

A Novel Biomechanical Approach for Preventing Spinal Disorders

26

Stan Banks

Transdermal Buprenorphine Delivery for Treatment of Chronic Pain and Oxycontin Addiction

14

Steven G. Van Lanen

Nucleoside Antibiotics Targeting Bacterial Translocase I

27

Trevor P. Creamer

Using Calmodulin to Probe the Role of Intrinsic Disorder in Biomolecular Recognition

33

HUMAN HEALTH AND DEVELOPMENT

Qunwei Zhang

Cigarette Smoke Extract Enhances the Effect of Ambient Ultrafine Particle on Endothelial Cells

45

Richard N. Cloud

Web Assisted Recovery 46

MATERIALS SCIENCE AND ADVANCED MANUFACTURING

Greg Schardein

Electron‐Beam‐Induced Deposition of Metal Nanostructures from Liquid Precursors

52


23

Haluk Karaca Development of Shape Memory Materials for Aerospace and Biomedical Applications

48

Handan Liu

Multifunctional SPIO‐Incorporated Polymer Nanodevices for Magnetothermally‐triggered Drug Delivery for Cancer Therapy

69

Hongwu Zhao

Coupled Viscous Vortex Particle Method and Unstructured CFD Solver for Rotorcraft Aerodynamic Interaction

66

Ibrahim Yucedag

Alpha Alumina Mositure Sensors for Trace Moisture Measurement

62

Issam Harik

High Performance Materials for Structural Repair

60

J. Zach Hilt

FTIR Imaging for Microscale Spatial Analysis of Hydrogel Patterning Reactions

55

Jeremy M. Rathfon

Selectively‐Stimulated Self‐Assembly of Polymer Thin Films into Nanometer‐Scale Air‐Bridges and Suspended Membranes

58

Kan Ni

Three‐Dimensional Fatigue Crack Growth Prediction of Surface Crack on Ti Tubes

65

Lu Wu

High‐Resolution Pulsed‐Field‐Ionization Ion Spectroscopy of Transition‐Metal‐Oxide Clusters

56

Liping Xue

Material Point Method ‐ A Unified Solver for Nonlinear Aeroelasticity and Fluid‐Structure Interactions in ASTE‐P Toolset

64

Mahendra Sunkara

A Reactor for Commercial Production of Metal Oxide Nanowires

51

Manish Sethi

Surface Interactions Between Biomolecules and Au Nanoparticles

53

Mehdi M. Yazdanpanah

Market Development and Manufacturability Scale Up of Nanoneedle Probes

59

Nagendra Dittakavi

Jet Noise Prediction Using Large Eddy Simulation and Acoustic Intensity Based Method of the ASTE‐P Toolset

67

Nicholas Wright

Development of Nanospring‐Based Device for Quick Remote Diagnostics by Analysis of Chemical Compounds in Human Breath

50

Ramji Kamakoti

Pure Particle Method for Fluid‐Structure Interaction Applications in ASTE‐P Toolset

63

Shouchun Deng

A Robust and Efficient Mesh Deforming Algorithm for Aeroelastic Modeling and Simulation

68

Stephen E. Rankin

Predictive Synthesis of Mesoporous Silica with Isolated Titanium Sites with Mixed Surfactants

47

Surendar R. Venna

Microwave Assisted Synthesis of SAPO‐34 Molecular Sieves by Phase Transformation of SAPO‐5

57

Suresh Rajaputra

Nanoporous Template Based Fabrication Approach to Solar Cells and Sensors

49

T. John Balk

Nanoporous Nickel As an Alternative to Raney Nickel

54

YuMing Zhang

Development of Advanced Welding Technologies

61

INFORMATION TECHNOLOGY AND COMMUNICATIONS

Ashok Kumar

Closed System Container Wireless Monitoring Systems

73

Biswajit Panja

Monitoring Runway Using Smart Sensor Networks

75


24

Chamila Walgampaya

Real Time Click Fraud Detection and Prevention

72

Daniel L. Lau

Integral Lens Arrays for On‐Tablet Pharmaceutical Anti‐Counterfeiting

74

Dongqing Chen

New Dental 3D Image Probe for Orthodontic Treatments

78

Olfa Nasraoui

Architecture Analysis of Peer to Peer Data Exchanges for Node Based Probing and Monitoring in Distribution of Contraband Material

77

Patrick Hu

Integrated Variable‐Fidelity Tool Set for Modeling and Simulation of Aeroservothermoelasticity‐Propulsion (ASTE‐P) of Aerospace Vehicles from Subsonic to Hypersonic

71

Solomon Antony

Use of Data Modeling Patterns: An Evaluation

76

Steve Dominick

Multi‐Projector Multi‐Touch Display

70

POSTER ABSTRACTS

25

ENVIRONMENTAL AND ENERGY TECHNOLOGIES 1. A Study of the Reactivity and Stability in the Presence of Hydrogen of Pd Nanoparticles Coated with Mixed Monolayers of Octylamines and Hexanethiolates Francis P Zamborini, and Moreno Monica* Department of Chemistry, University of Louisville Our group recently synthesized 3.0 nm diameter Pd nanoparticles (NPs) modified with octylamine (C8NH2), hexanethiolate (C6S), and mixed monolayers of the two ligands. The average composition of the Pd NPs was Pd919(C8NH2)168‐x(C6S)x, where we varied x to be 0, 3, 10, 17, 34, 84, and 168 by synthesizing pure C8NH2 Pd NPs and place‐exchanging the C8NH2 with various amounts of C6S. We studied the reactivity of the various Pd NPs with H2 by monitoring the UV‐Vis spectrum of solutions of Pd NPs with H2 bubbling over time and by monitoring the change in resistance of solid‐state films of Pd NPs when exposed to various H2 concentrations. The reactivity to H2 and Pd NP stability varied with C8NH2:C6S ratio: When x = 0‐10, the Pd NPs react strongly with H2, leading to aggregated particles in solution or large irreversible changes in morphology for films. This is accompanied by loss of the C8NH2 and the increased film conductivity by 2‐5 orders of magnitude. When x = 168, the Pd NPs are stable against aggregation or large morphology changes, but they are also not highly reactive to H2 as determined by minimal changes in resistance in the presence of H2 compared with pure C8NH2‐coated Pd NPs. Finally, when x = 17, 34, and 84, the Pd NPs are fairly stable, exhibiting minimal aggregation or morphology changes, and they readily react with H2 based on the large, reversible change in film resistance in the presence of H2 from 9.6% down to 1.0% H2, as determined by electronic measurements and verified by spectroscopy measurements of the Pd NPs in solution. Fundamentally, this work is interesting because it shows that reactivity and stability can be controlled by using a mixture of different coordinating ligands as protective groups on NP surfaces. The R‐NH2 ligands allow reactivity while R‐S ligands prevent it.

The correct mixture allows both reactivity and NP stability. From a practical view, this work could lead to the design of improved Pd NPs for sensing and catalysis application. 2. Cyclic Recurrent Event Modeling and Application to Climate Data A. Adekpedjou (1), S. Foster (2) , J. Polcer (3), and J. Quiton* (3) (1) Department of Mathematics and Statistics, Missouri University of Science and Technology; (2) Kentucky State Climatologist, Director of the Kentucky Mesonet, and Professor at the Department of Geography and Geology at Western Kentucky University; (3) Department of Mathematics and Computer Science, Western Kentucky University In this poster, we present two modeling approaches based on hazard‐based stochastic processes from which we model k recurrent and cyclic events. We assume that subjects or units are observed under a fixed monitoring period and the initial state of the subjects are known. In the joint modeling approach, we postulate that the gap times are independently distributed generated by one of the k distinct hazard functions, while in the full likelihood modeling, we assume that the gap times share a common baseline hazard function. Parametric and semi‐parametric estimators are shown and applied to alternating binary‐transformed wind data provided by the Kentucky Mesonet. J. Polcer and J. Quiton acknowledge research support from Kentucky Science and Engineering Foundation (KSEF‐2013‐RDE‐012), Western Kentucky University Junior Faculty Scholarship (No. 223149), and computing support from the Kentucky NSF‐ EPSCoR Research Startup Fund (RSF‐031‐06). In addition, J Polcer acknowledges summer support and data from the Kentucky Mesonet. 3. Generalized Bathtub Models for Binary‐Transformed Climate Data S. Foster (1), J. Polcer* (2), and J. Quiton (2) (1) Kentucky State Climatologist, Director of the Kentucky Mesonet, and Professor at the Department of Geography and Geology at Western Kentucky University; (2) Department of

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Mathematics and Computer Science, Western Kentucky University In this poster, we present our current research on modeling binary‐transformed climate data. In particular, we focused on wind speed data where we transformed the original data into low or high‐energy states based on an arbitrary wind speed threshold. Under a binary‐transformed data, our main objective is to find stochastic models that can characterize the duration of the low and high energy states. Our present modeling approach is through a hazard‐based specification in an alternating recurrent event setting. Initial results led us to the search for a general class of bathtub models flexible to site and season changes. Survivor functions for the low and high states are obtained using least squares or maximum likelihood methods. Finally, we will demonstrate the performance of some bathtub models using selected wind data provided by the Kentucky Mesonet. The authors acknowledge research support from Kentucky Science and Engineering Foundation (KSEF‐2013‐RDE‐012), Western Kentucky University Junior Faculty Scholarship (No. 223149), Kentucky NSF‐ EPSCoR Research Startup Fund (RSF‐031‐06), and the Kentucky Mesonet. 4. Planar Fiber‐Optic Chip for Fully Guided Raman Interrogation of Molecular Adsorbates Jennifer L Burnett*, Nathan A Webster, Joseph M Lynch, and Sergio B Mendes Department of Physics and Astronomy, University of Louisville Planar fiber‐optic chips (FOC) make use of the evanescent field effects of side‐polished fibers, creating a fully integrated device which alleviates bench top optical alignment. The use of the FOC has been exhibited for fluorescence, absorbance, electrochemical investigations, and as presented here, Raman spectroscopy. The fabrication of the FOC begins with a side‐polishing process of a multi‐mode fiber. The fiber core is exposed creating a D‐shape when viewed laterally. The polished portion of the fiber is mounted in a V‐groove of a Si wafer platform for easier handling. Through a seed‐mediated growth method, gold nanoparticles

(AuNP) including rods, spheres, and platelets, are adsorbed to the functionalized surface of the FOC. The Raman‐active analyte p‐aminothiophenol (p‐ATP) is then adsorbed to the AuNP. Electric field enhancement near these AuNP allows for augmentation of both the incident laser line and the resultant Raman signal of the analyte without creating an obstructive background. A 632.8 nm laser line was coupled into the FOC and excitation of the p‐ATP Raman signal by the device was observed. Additionally, when excited externally, it was demonstrated that the Raman signal could be coupled into the FOC and collected using conventional spectroscopic equipment. Future prospects involve coupling the Raman excitation and collection into one process to utilize the advantages of a fully guided system. Pairing this capability with the established facilities of the FOC make this a very useful tool in the field characterization. 5. Nano‐Cracks Insite Micron‐Sized Eelectrode Particles Can Change The LI‐ION Transport Mechanism And Diffuse Induced Stress Rutooj D. Deshpande* (1), Stephen J. Harris (2), Yue Qi (3), Indrajit Dutta (4), Yang‐Tse Cheng (1) (1) University of Kentucky; (2) Electrochemical Energy Research Lab, General Motors Global, R&D, Warren, MI; (3) Chemical Sciences and Materials Systems Laboratory; (4) Trison Business Solutions, Inc., Department of Chemical and Materials Engineering, University of Kentucky Following earlier work of Huggins and Nix, several recent theoretical studies have used the shrinking core model to predict intra‐particle Li concentration profiles and associated stress fields. A goal of such efforts is to understand and predict particle fracture, which is sometimes observed in degraded electrodes. In this paper we present experimental data on LiCoO2 and graphite active particles, consistent with previously published data, showing the presence of numerous internal pores or cracks in both positive and negative active electrode particles. New calculations presented here show that the presence of free surfaces, from even small internal cracks or pores, both quantitatively and substantially qualitatively alters

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the internal stress distributions such that particles are prone to internal cracking rather than to the surface cracking that had been predicted previously. In addition, we suggest that, thus, the fracture strength of particles will likely depends largely on the internal microstructure of particles, about which little is known, rather than on the intrinsic mechanical properties of the particle materials. The validity of the shrinking core model for explaining either stress maps or transport is questioned for particles with internal structure, which includes all secondary electrode particles. 6. Experimental Testing of the Wavelet‐Based Classification Algorithm of Active/Inactive Unexploded Ordnance Bruce Kessler, Phillip Womble, Alexander Barzilov*, and Joseph Howard Applied Physics Institute, Western Kentucky University The Pulsed Fast Thermal Neutron Analysis (PFTNA) method that noninvasively indicates the elemental composition of the test item has been used to determine the active/inactive status of unexploded ordnance (UXO). The method utilizes the neutron‐induced gamma rays – isotopic fingerprints – to evaluate the chemical composition of the object under scrutiny. Neutron‐based methods require a skilled analyst to interpret the spectral data collected. We have developed a wavelet‐based algorithm that automatically interprets the spectral data and makes a classification of the substance. This algorithm has been experimentally tested using a laboratory prototype system consisting of a deuterium‐tritium pulse neutron generator and a high‐purity germanium gamma ray detector. The results of experimental tests of the algorithm on PFTNA data in UXO determination applications are described. 7. Broadcast Methods for the Elimination of Random Anomalous Peak Loads Kyle Moss* (1), Phil Womble (1), and Jonathan Quiton (2) (1) Applied Physics Institute, Western Kentucky University; (2) Department of Mathematics and Computer Science, Western Kentucky University

A problem faced around the globe is that of increasing power consumption. Population growth combined with increased demand from industry lead to a geometric progression of power consumption. The intermittent nature of these heavy demands results in peak power loads on the grid especially during times of excessive heat. In order to help control these random anomalous peak loads, we propose to develop a system which will give electrical utility providers the ability to control AC units on both residential and commercial units. Using communication systems already in place, an integrated switching unit on the AC unit, and algorithms to model multiple environmental conditions, our system will be able to shift and reshape peak electrical loads on the power grid. The distribution strategy is targeted primarily to power producers. Incentives by the large power production companies could be passed along to sub‐users of the system to increase interest in the system. Our system uses resources available through various OEMs and mature switching technology which reduces overall risk, however, the combination of these resources with new algorithms to predict peak load occurrences produces a system which is state‐of‐the‐art. 8. CFD Simulation of Flatback Airfoil Matthew Fuller*, and Yongsheng Lian Department of Mechanical Engineering, University of Louisville Wind generated energy is inhibited by size limitations as well as cost limitations due to size requirements. Due to the ever increasing power demands of the human population alternative sources of energy, such as wind power, are desired to produce at least equivalent if not more power than traditional fossil fuels. This desire incites ever increasing size requirements to produce power on the scale of non‐renewable resources. The increase in size required to produce even a comparable value of energy to present resources has begun to reach a limit in terms of material composition and structural stability. To quell the trend of increasing size in wind power systems alternative wind turbine blade designs are investigated and evaluated to increase power production and efficiency of

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present size machines. These alterative airfoil blade designs will be investigated numerical with computational fluid dynamics techniques and the results will be characterized in terms of aerodynamic benefits. The benefits of a blunt trailing edge style airfoil are shown to be increased lift production at the expense of increased drag force. This increase in drag is shown, through geometry modification, to be reduced through the use of treatments to the blunt trailing edge. BIOSCIENCES 9. The Environment of Young Star PDS 144S Jeremy Hornbeck* (1), Carol Grady (2), and Gerald Williger (1) (1) Department of Physics and Astronomy, University of Louisville; (2) NASA Goddard Flight Center Understanding the evolution of the solar system was, in the past, limited to the study of the solar system itself. The study of young, high inclination (seen close to edge‐on) circumstellar disks has now become an invaluable resource for describing the evolution of young stars. In this study we look at the young star system PDS 144. This star system is composed of two stars, PDS 144 north and PDS 144 south (PDS144N and PDS144S) both of which are Herbig Ae stars (Vieira et al 2003). PDS 144N is highly inclined to our line of sight and thus has a dark band of dust occulting the central star from view (Perrin et al 2004). Our focus in this discussion however is PDS 144S. Originally it was believed that PDS 144S was seen near zero inclination, however we are able to show that it too is highly inclined. Unlike PDS 144N, light from the central star PDS 144S is seen directly. Our analysis of the multi‐wavelength high resolution HST data clearly shows the bi‐polar nature of the surrounding nebulosity that only accompanies stars with disks seen at high inclination. Our recent HST data has allowed the calculation of the proper motion of the system to a much higher degree of certainty, and it shows the system is in fact a binary system; a fact that until now was under debate. This information will further guide us in defining the parameters that govern planet formation.

10. A Unique Type of Glycosylation is Essential in Cardiomyocytes During Heart Failure Lewis J. Watson* (1,2), Gladys A. Ngoh (1,2), Heberty T. Facundo (2), and Steven P. Jones (1,2) (1) Department of Physiology and Biophysics; (2) Institute of Molecular Cardiology, University of Louisville Heart disease is the leading cause of morbidity and mortality in the developed world. It is well known that in heart failure, a metabolic shift from burning predominantly fatty acids to a more glycolytic metabolism occurs. Our lab is focused on the role that the post‐translational modification O‐GlcNAc plays in cardiac physiology. Our current aim is to determine what role O‐GlcNAc signaling plays in the development and progression of infarct‐induced heart failure. We hypothesized that the glucose derived post‐translational modification O‐GlcNAc would be differentially regulated and play prominently in the response to heart failure. To test this hypothesis, we first subjected wild‐type mice to permanent coronary ligation or sham surgery. After five days, we found cardiac OGT (the enzyme that adds O‐GlcNAc to proteins) and cardiac O‐GlcNAc levels were both elevated. We then subjected an inducible, cardiomyocyte‐specific OGT knock‐out mouse to the same surgery and followed them for four weeks using echocardiography. We found that OGT deletion significantly exacerbated heart failure. These same mice were then subjected to histological assessment for typical markers of remodeling. OGT deletion significantly increased both fibrosis and apoptosis in the surviving myocardium. We conclude that OGT ablation exacerbates infarct‐induced heart failure by increasing pathologic remodeling in the remote, surviving myocardium. 11. Title: Analysis of Binding to Vascular Walls under Flow Using a Bioreactor Michael Fannon* (1), Bing Zhao (1), and Kimberly Forsten‐Williams (2) (1) Department of Ophthalmology and Visual Sciences, University of Kentucky; (2) Department of Chemical Engineering, Virginia Tech

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Two dimensional cell studies, although invaluable in many applications, cannot suitably accommodate the three dimensional architecture and dynamic forces that define circulatory systems. In this study we used a bioreactor with endothelial‐lined capillary tubes under pulsatile flow to model the vessel environment. A first pass approach was used to better measure binding potential. Heparin‐binding molecules were used because of their well‐known roles in angiogenesis and tumor growth. Binding experiments showed substantial binding of molecules under flow rates typical of capillary flow (~ 0.65 ml/min), however rates only slightly higher virtually ablated binding of these molecules to vessel walls. Removal of the heparan sulfate moieties on endothelial surfaces using heparinase reduced binding to similar levels but had no significant effect on molecules that do not bind heparin. Our data suggest that the probability of capture of these molecules by vascular endothelium is regulated both by the level and type of proteoglycan on the cell surface and by the flow rate. The regulation of binding by flow rate is likely common to all circulating molecules and this probability of binding is low above capillary flow rates without the benefit of multiple passes. This characteristic would have substantial regulatory effects on molecules that may have short half‐lives in circulation and underscores the optimal environment for bioavailability in capillaries. 12. Fast Screening Target Sites for RNAi‐Based Termite Controls Jing Shi*, Pei Liang, and Xuguo Zhou Department of Entomology, University of Kentucky There are over 2,500 species of termites patrolling on this planet. Because of their unique capabilities of digesting woody materials, termites represent a tremendous challenge to the human society, and are considered by many as one of the most destructive insect pests in the world. The combined damages and control costs exceeds $30 billion per year. Because of their unique biology (e.g., subterranean life style) and social behavior, conventional termite control agents have been predominantly applied underground as a “chemical barrier”. The persistency and highly toxic nature of

effective termiticides post a potential serious treats to our surrounding environment and human health. Compared to the traditional “barrier” soil treatment, a more environmentally friendly approach is through baiting, which involves recruiting termites to feed on cellulosic substrates impregnated with low concentrations of slow‐acting insecticides. In order to reduce our reliance on broad‐spectrum termiticides and expedite the speed of colony elimination through baiting, we selected a genetic active ingredient to replace the insecticide component in the bating system. Here, the actual active agent is a double stranded ribonucleic acid (dsRNA), a genetic messenger between DNA and protein. By interrupting the message transferring processes, challenged organisms will lose certain functions, in extreme cases, result in death. Such phenomena are called RNA interference (RNAi), and here, we use this technology to screen for the potential target sites for dsRNA‐mediated termite baiting controls. 13. Effective Small RNA Destruction by Short Tandem Target Mimics through the Small RNA Degrading Nucleases in Arabidopsis thaliana Yiyou Gu (1), Xiaoyun Jia (1), Xuemei Chen (2), Xiaoqing Tang (1) and Guiliang Tang* (1) (1) Gene Suppression Laboratory, Department of Plant and Soil Sciences and KTRDC, University of Kentucky; (2) Department of Botany and Plant Sciences, University of California‐Riverside, Riverside, CA An endogenous, long noncoding RNA IPS1 inhibits the activity of miR399 through target mimicry in Arabidopsis1. Although the application of IPS1‐based target mimicry to inhibit a few other miRNAs has been reported, the effectiveness of the approach and the underlying mechanism still await further investigation. Here, we report the development of a novel and highly effective technology that targets specific endogenous miRNAs or siRNAs for destruction. We show that the expression of short tandem target mimics (STTMs), two short sequences mimicking small RNA target sites separately by a linker of an empirically determined optimal size, leads to the degradation of the targeted small RNAs by the

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small RNA degrading nucleases SDNs. The efficacy of the technology was demonstrated by the strong and specific developmental defects triggered by STTMs targeting two miRNAs and a trans‐acting siRNA. In summary, we have developed a novel approach for the destruction of endogenous small RNAs, thereby providing a powerful tool for functional genomics of small RNA molecules in plants. 14. Transdermal Buprenorphine Delivery for Treatment of Chronic Pain and Oxycontin Addiction Stan Banks*, Dana Hammell, Miro Golinski, Jeff Howard, and Audra Stinchcomb AllTranz Inc. Buprenorphine (BUP) is an opiate drug (similar to morphine) that has been used for over 25 years for the management of pain. BUP, in most cases, is as clinically effective as morphine, has a longer duration of action, and a more favorable safety profile. It is currently marketed as a sublingual (under the tongue) tablet for opiate addiction (like Oxycontin addiction) treatment in the United States, a transdermal patch (Europe) and as an injectable pain medication. The development of a transdermal patch prodrug product for use in the United States could provide a safer alternative to other potent opiates that can cause patients to stop breathing if the dose is too high. Prodrugs are chemically altered forms of a drug that can improve the skin permeation rate, but change back into the original drug in the body. Prodrugs are better in this type of patch system because less drug needs to be used and the patches can be made smaller in size. In this study, buprenorphine prodrugs were evaluated for transdermal delivery success in experiments using tummy‐tuck surgery skin. Several prodrugs were identified with substantial improvements in skin permeation rates, as compared to BUP. These successful prodrugs are currently being formulated into patches in preparation for future toxicology studies and clinical trials. AllTranz is also adding an abuse deterrent system to these patches so that drug addicts can’t get “high” by chewing the patches (chiclets) or by dissolving the patches and injecting

the contents. Funded by NIH/NIDA grant R43 DA 26266. 15. Differential Scanning Calorimetry: A novel Tool for Discriminating the Extent of Intraepithelial Neoplasia and Invasive Carcinoma of the Cervix Nichola C. Garbett* (1), Daniel Metzinger (1,2), Lynn Parker (1,2), C. William Helm (1,2), A. Bennett Jenson (1) and Jonathan B. Chaires (1) (1) James Graham Brown Cancer Center, University of Louisville; (2) Division of Gynecologic Oncology, University of Louisville Invasive cervical cancer (IC) can be prevented if pre‐cancerous lesions on the cervix (CIN) are detected and treated. Current screening methods cannot reliably differentiate women with significant precancerous lesions (HSIL) that require treatment from those with lesions that do not require treatment. This means that many women have to undergo additional investigations. Once an invasive carcinoma of the uterine cervix is detected the principal need is to determine whether or not the disease is confined to the cervix without metastasis. Differential Scanning Calorimetry (DSC) provides profiles of the behavior of plasma biomolecules in response to heat yielding a denaturation thermogram that is sensitive to the weighted sum of proteins in solution and their interactions with binding ligands. We have found specific changes in plasma can be detected in several types of cancer and are evaluating the potential of DSC as a clinical diagnostic tool in cervical neoplasia. The method is rapid and requires only a small blood sample. Our results have shown that DSC can discriminate plasma from healthy individuals from those with HSIL and IC with no significant effect of age, ethnicity, smoking or parity. Additional specimens are being collected and analyzed to define a DSC signature characteristic for each stage of pre‐cancerous lesion through cancer progression. The method has clear potential in screening for HSIL and IC. 16. Hip Strengthening Technology for Hip Fracture Prevention Michael Voor* and Robert Burden

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Orthopaedic Bioengineering Lab, University of Louisville Hip fractures are devestating to the individual (24% one year mortality) and to society ($81,000 cost per episode). New technology has been developed that can significantly strengthen the proximal femur of individuals with osteoporosis and thus prevent the vast majority of these fractures. This project is the development of that technology into a commercially viable orthopaedic product. 17. Hydroxyapatite Cement Augmented with Xenograft Bone Improves Incorporation into Cancellous Defects Michael Voor* (1), Robert Burden (1), Eric Yoder (1), Seid Waddell (1), Leon Driessens (2), and Pieter Buma (2) (1) Orthopaedic Surgery, University of Louisville; (2) University Medical Center St Radboud, Nijmegen, the Netherlands The purpose of this investigation was to determine the effects of adding decalcified xenograftbone on hydroxyapatite cement(HAC)resorption, new bone formation, and strength over ten weeks in an established animal model. The hypothesis was that the presence of processed xenograftbone particles would increase the incorporation of the HAC and formation of new bone within the HAC without decreasing its strength. 18. Dual Insulin‐stimulating and Antibacterial Activities of Mogrosides from Lo Han Kuo Fruit (Siraitia grosvenorii) Chifu B. Huang*, and Jeff Ebersole Oraceuticals, Inc. Dental caries is the predominant cause of tooth loss in children and young adults, and is the most prevalent of all chronic diseases among children in the US, 5X more common than asthma and 7X more common than hay fever. Lo Han Kuo (LHK) fruit (Siraitia grosvenorii Swingle) has been used in China for centuries as a sweetening agent, as well as phytomedicine to treat sore throats and diabetics. Mogrosides of the LHK fruit are the sweetening agents, which are estimated as much

as 300‐400 times sweeter than sucrose. We recently reported that the Luo Han Kuo (LHK) fruit extract exhibited antibacterial activity against oral bacteria and mogroside V of LHK fruit also exhibited a significant activity in stimulating insulin secretion in the beta cells, which could partially be responsible for the anti‐diabetic activity of LHK fruit extract. We evaluated and compared the biological functions of a group of the related mogrosides of LHK fruit, including, mogroside II, III, IV, V, VI, 11‐o‐Mogroside V, and Siamenoside I. The experimental data supported that like mogroside V, the other mogrosides have the dual anti‐bacterial and insulin‐stimulating activities. There appear to have variation in the bioactivity of the mogrosides and that the number and the position of the sugar groups could play some role in the insulin secretion activity but play little role in the antibacterial activity. The mogrosides of LHK could be attractive sweetener to consume as it could improve the oral health of diabetic patients due to its dual bioactivities. 19. Investigation of the Mitochondrial Neuroprotective Effects of Dopamine Neuron Stimulating Peptide‐11 Jadwiga Turchan‐Cholewo (1), Kristen A. Kelps (1), and Luke H. Bradley* (1,2) (1) Departments of Anatomy and Neurobiology; (2) Molecular and Cellular Biochemistry, University of Kentucky As observed with the mature growth factor, dopamine neuron stimulating peptide‐11 (DNSP‐11), a peptide derived from the prosequence of the glial cell‐line derived growth factor (GDNF), was shown recently to offer neuroprotective and neurorestorative effects in dopaminergic cell culture and parkinsonian rat model systems. However, unlike GDNF, DNSP‐11 was found to prevent staurosporine‐induced toxicity in nutrient‐deprived dopaminergic B65 cells, and its neuroprotective effects included preventing cytochrome c release from mitochondria. We hypothesize that DNSP‐11 exhibits its neuroprotective effects by mediating mitochondrial apoptosis. To test our hypothesis, dopaminergic cell lines MN9D and B65 were

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treated with DNSP‐11 plus several mitochondrial‐specific toxins to evaluate their effects. Time and dose responses were screened by measuring mitochondrial potential activity, caspase‐3 activity, and TUNEL staining assays. In addition, proteomic profile analyses were performed to determine changes in the membrane, cytosolic and mitochondrial proteins involved in DNSP‐11 protection against complex II‐specific toxin 3‐nitropropionic acid. Finally, FACS analyses were performed to determine time and dose dependent localization of DNSP‐11 in the cell. These data support the mitochondrial neuroprotective hypothesis and further suggest that DNSP‐11 is a promising candidate for further evaluation as a downstream therapeutic for age‐related neurodegenerative diseases, like Parkinson’s disease. 20. Identifying Native Plant Species Containing Metabolites with Novel Activity as Potential Pharmaceuticals Manish Kulshrestha* (1), Joseph Lutz (2), Dustin Brown (2), Trent Rogers (2), Samir Gunjan (2), and John Littleton (1,2) (1) Naprogenix, Inc.; (2) University of Kentucky‐KTRDC Plants have evolved many metabolites designed to protect the species against microbial or insect attack. These are sometimes of value as medicines, but identifying which species contains the metabolites of greatest potential value using conventional methods is arduous and expensive. Naprogenix has developed methods for “differential” high throughput pharmacological screening of crude plant extracts which should identify promising species more rapidly. Using this approach we screened a ~1000 species native plant extract “library” for metabolites which selectively activate a subtype of nicotinic receptors for acetylcoline (nicAChRs) in the human brain. We believe that plants are a good potential source of “defensive” metabolites with this activity because these receptors have homology with the major excitatory receptors in the insect brain. From the pharmaceutical viewpoint these “alpha7” nicAChRs are important therapeutic targets in neuro‐

degenerative disease and inflammation. We found only 7 species that contained this activity selectively, and these included Solidago and Lobelia species that had not previously been investigated. Chemical separation, including preparative HPLC and assay‐guided fractionation has now purified the active compounds in S nemoralis and L. cardinalis, and we have tentative identification of these (a flavonol and an alkaloid respectively). In neither case were the metabolites suspected of having this potentially valuable activity. We are now evaluating the effects of the purified compounds in human cell lines, and are beginning to apply our proprietary “Natural Products Genomics” technology (see accompanying poster) to the optimization of the active metabolites generated by cell cultures of these species. 21. Optimizing Pharmaceutically‐Valuable Metabolites in Medicinal Plant Species by Directed Evolution Noel Monks* (1), Samir Gunjan (2), Baochun Li (1), Jordan Smith (1), Joseph Lutz (2), Dustin Brown (2), Trent Rogers (2), Deane Falcone (1) and John Littleton (1,2) (1) Naprogenix, Inc.; (2) University of Kentucky‐KTRDC Many medicines derived from plants are complex molecules that are beyond the capacity of synthetic chemistry. This causes problems for production because the plant source commonly only produces tiny amounts of highly active metabolites, and makes generating “better” molecules by synthetic chemistry based on the original structure extremely difficult. Two examples from cancer chemotherapy are the vinca alkaloids from Catharanthus roseus and the taxoids from Taxus brevifolia. Due to the limitations above, these are extremely expensive medicines and there are very few novel synthetic derivatives. Naprogenix is using a proprietary technology “Natural Products Genomics” to increase yields of the known active compounds in cell cultures from these species, but the same technology is also capable of using the plants own genomic/synthetic capability to generate metabolites which might become novel medicines.

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Using C. roseus as the example, a large population of hairy root cultures carrying random gain‐of‐function mutations is generated and subjected to selection that favors the survival of mutants in which the vinca alkaloid pathway is activated. The resistant sub‐population is then screened against a panel of differential sensitive cell lines. Because the known active vinca alkaloids have a specific “signature” of activity, we are able to determine whether a mutant culture is over‐producing either a known vinca alkaloids, or a novel metabolite with a different spectrum of activity. This is then confirmed by chemical analysis. When applied repeatedly this mutation/selection/screening technology is capable of directing the evolution of plant cells toward potentially valuable pharmaceutical metabolites. 22. Toward Early Diagnosis of Lung Cancer Ayman El‐Baz Bioengineering Department, University of Louisville Our long term research goal is to develop a fully automated, image‐based diagnostic system for early diagnosis of pulmonary nodules that may lead to lung cancer. In this paper, we focus on generating new probabilistic models for the estimated the growth rate of the detected lung nodules from Low Dose Computed Tomography (LDCT). We propose a new methodology for 3D LDCT data registration which is non‐rigid and involves two steps: (i) global target‐to‐prototype alignment of one scan to another using the learned prior appearance model followed by (ii) local alignment in order to correct for intricate relative deformations. Visual appearance of these chest images is described using a Markov‐Gibbs random field (MGRF) model with multiple pairwise interaction. An affine transformation that globally registers a target to a prototype is estimated by the gradient ascent‐based maximization of a special Gibbs energy function. To handle local deformations, we displace each voxel of the target over evolving closed equi‐spaced surfaces (iso‐surfaces) to closely match the prototype. The evolution of the isosurfaces is guided by a speed function in the directions that minimize distances

between the corresponding voxel pairs on the iso‐surfaces in both the data sets. Preliminary results show that the proposed accurate registration could lead to precise diagnosis and identification of the development of the detected pulmonary nodules. 23. Appearance Analysis for Diagnosing Malignant Lung Nodules Ayman S. El‐Baz Bioengineering Department, University of Louisville An alternative method of diagnosing malignant lung nodules by their visual appearance rather than conventional growth rate is proposed. Spatial distribution of image intensities (or Hounsfield values) comprising the malignant nodule appearance is accurately modeled with a rotation invariant secondorder Markov‐Gibbs random field. Its neighborhood system and potentials are analytically learned from a training set of nodule images with normalized intensity ranges. Preliminary experiments on 109 lung nodules (51 malignant and 58 benign ones) resulted in the 96.3% correct classification (for the 95% confidence interval), showing the proposed method is a promising supplement to current technologies for early diagnostics of lung cancer. 24. Molecular Characterization of Microbial Symbionts in Introduced Species Jennifer A. White* and Cheryl B. Lindsay Department of Entomology, University of Kentucky What makes an exotic species invasive in a novel habitat? Despite the major economic and ecological costs associated with invasive insect species, we cannot yet successfully predict characteristics that predispose a species toward invasion, nor do we understand the evolutionary changes that occur following establishment in the new habitat. One aspect of introduced species biology that has been neglected almost entirely is the role of bacterial endosymbionts. Symbionts influence many aspects of the life history and ecology of their arthropod hosts (e.g., reproduction, dispersal, defense); these factors, in turn, can affect establishment and spread of

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introduced species. We propose to test the novel hypothesis that introduced species have fewer endosymbionts in their exotic than native ranges by comparing their microbial symbiont communities using denaturing gradient gel electrophoresis [DGGE]. All of the insect species proposed for investigation are relevant to Kentucky as invasive pests or introduced biological control agents of invasive species. The results will therefore provide insight into successful biological control of invasive species that have local economic or ecological impact. Additionally, the preliminary data collected in this study will be used to formulate further general hypotheses about endosymbionts in invasive species, and specific hypotheses about the ecological role of symbionts in individual systems. 25. Neuroprotective and Neuropreservative Effects of Curcumin Against Oxidative Insults in Neuronal Cultures Ray B.* (1), Bailey J.A. (1), Kotwal G. (2), Tran H. (2), Pathak Y.V. (2), and D.K. Lahiri (1) (1) Department of Psychiatry, Laboratory of Molecular Neurogenetics, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN; (2) Sullivan University College of Pharmacy‐Louisville Curcumin is a yellow colored polyphenol compound obtained from the rhizome of the plant Curcuma longa. The dried rhizome of the plant is also known as turmeric, used as a culinary compound in various countries in south East Asia. From ancient times, apart from its culinary use, turmeric is also used to treat several ailments like skin diseases, rheumatoid arthritis and inflammation. Curcumin, which is one of the active ingredients of turmeric, was shown to possess potent anti‐inflammatory and anti‐carcinogenic properties. Among other molecular effects, anti‐inflammatory action of curcumin is mainly due to its ability to inhibit the activation of nuclear factor kappa beta (NF?B) (Ray et al., 2009). Our goal is to determine whether curcumin can be protective against neurodegeneration and its associated brain disorders, such as Alzheimer’s disease (AD). AD, a progressive neurodegenerative disorder of the

elderly, is characterized by deposition of amyloid ß (Aß) mediated plaques and subsequent severe neuro‐inflammation caused by reactive oxygen species (ROS). Interaction between oligomeric or deposited Aß and activated macrophases also generates a series of cyto‐chemokines leading to neuronal death. Several pre‐clinical researches revealed that curcumin can be effective in the treatment of AD because of its potent anti‐inflammatory activity and Aß lowering property. We have tested the neuro‐protective effect of curcumin in cell culture, where we co‐treated neuronal SK‐N‐SH cells with ROS (H2O2) and different doses of curcumin. Measurement of neuronal morphology and cell viability by luminescence based CTG assay revealed that curcumin protects neuronal cells from ROS mediated insults. Furthermore, in a separate experiment, curcumin was found to increase the levels of one of the important pre‐synaptic proteins SNAP25 in neuronal cells. It is worth mentioning that potent anti‐oxidant properties of some other compounds present in the turmeric are collectively called curcuminoids. Both curcumin and curcuminoids are poorly soluble in aqueous medium, which might be a hindrance in achieving their therapeutic effects when administered through oral route. Nano‐emulsifying these compounds can possibly increase their bioavailability and decrease any adverse effects because of the slow release of the drugs from the emulsion. Thus, the unique neuroprotective effect of curcumin coupled with nano‐emulsification ability of these natural agents can be an appropriate step for developing new drugs to halt and treat several neuro‐degenerative disorders, such as AD. 26. A Novel Biomechanical Approach for Preventing Spinal Disorders Shaun K. Stinton* (1), Robert Shapiro (1,2), David R. Mullineaux (2), William O. Shaffer (4), R. Carter Cassidy (3), and David D. Pienkowski (1,3) (1) Biomedical Engineering, University of Kentucky; (2) Kinesiology and Health Promotion, University of Kentucky; (3) Orthopaedic Surgery, University of Kentucky (4) Northwest Iowa Bone, Joint and Sports

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Disorders of the spine are an expensive and debilitating problem that will grow with the aging population and increasing prevalence of osteoporosis. Our central hypothesis is that static (posture) and dynamic (gait) related abnormal loading of the spine interact with age‐weakened tissue to produce a series of degenerative effects that culminate in disc degeneration and spine fractures. The ultimate goal of our research is to reduce the incidence and severity of spontaneous vertebral compression fractures by identifying motion and postural patterns that could lead to increased loading of the vertebrae resulting in these fractures over time. In Phase I of this study, a non‐invasive method to measure spinal motion was developed and the accuracy of the system was determined by using bone pins and skin markers in cadaver torsos. Phase II uses this validated measurement system in human subjects to record motion data during gait in three subject groups: Thin, Caucasian women over 50 who have a previous vertebral compression fracture; thin, Caucasian women over 50 without a spinal fracture; and thin, Caucasian women under 30 without a spinal fracture. Thin, Caucasian women are the population that most frequently suffers vertebral compression fractures. The motion data will be compared between subject groups in an attempt to identify the key parameters of gait or posture that place subjects “at‐risk” for developing these fractures. Identifying at‐risk subjects could lead to simple, inexpensive and noninvasive counter‐measures (targeted strength training, orthotics, etc.) that could help prevent/retard the development of these debilitating spinal disorders. 27. Nucleoside Antibiotics Targeting Bacterial Translocase I Steven G. Van Lanen*, Zhaoyong Yang, and Xiuling Chi College of Pharmacy, University of Kentucky Several nucleoside antibiotics are known that inhibit the enzyme bacterial translocase I involved in peptidoglygcan cell wall biosynthesis. Capuramycins are one such family of compounds that are currently under development for the

treatment of infections caused by Mycobacterium tuberculosis. The biosynthetic genes for the capuramycins A‐500359 and A‐503083, both from Streptomyces species, have been identified, and three enzymes have been characterized in vitro to reveal a critical mechanism of self‐resistance to capuramycins and a new strategy for amide bond formation in antibiotic biosynthesis. 28. Wireless Temperature Sensing System for Children Doug Jackson*, Jack Blake, David Miller, John Naber, Kevin Walsh, Charles Woods, and Brad Keller University of Louisville Three engineers with the University of Louisville’s (UofL) Electrical and Computer Engineering (ECE) Department have teamed with two UofL pediatric physicians to develop and validate a system that remotely monitors body temperature in young children. This team of engineers and doctors has also engaged two business and marketing experts to help commercialize the technology through a start‐up company called Simon Sounds LLC. The purpose of this novel and patentable device is to allow parents to monitor in real‐time the temperature of their young children and alert them if the temperature has exceeded a predetermined threshold. This technology is required due to the association of rapid changes in body temperature with high risk neurologic events (seizures). The proposed wireless system to continually monitor temperature remotely is called FeverGuard™. 29. Equine Medication Regulation: Stable Isotope Internal Standards and Certified Reference Standards Rodney Eisenberg (1), Julio Gutierrez* (2), Gabrielle Herrensmith* (2), Wojtek Karpiesiuk (2), Thomas Tobin (2), Job Tharappel (2), Charlie Hughes (2), Sihui Long (2), and Li Tiong (2) (1) Frontier BioPharm‐Richmond; (2) University of Kentucky Regulators of equine events now recognize the need for defined regulatory “cut‐offs” or “thresholds” for “trace” residues of therapeutic

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medications, thereby requiring accurate forensic quantification of residues of these medications. This creates a need for certified reference standards and stable isotope internal standards for use in medication analysis. To date, our research group has synthesized about 40 reference standards and has provided at least 20 unique certified standards and/or their appropriate stable isotope internal standards to racing chemists world‐wide. The need for regulatory controls on equine therapeutic medications is unlikely to depart; therefore, there is an ongoing need for reference standards and internal standards to fulfill the world‐wide requirement to regulate equine therapeutic medications to the highest scientific and forensic standards. 30. Nutraceutical Nano Emulsion to Deliver Antioxidants for Neurodegenerative Diseases Y.V. Pathak (1), H. Tran (1), Girish Kotwal* (1), B. Ray (2), D. Lahiri (2), V. Ramesh (3) and Chin Ng (4) (1) Sullivan University College of Pharmacy‐Louisville; (2) Laboratory of Molecular Neuro‐genetics, Institute of Psychiatric Research, Indiana University Purdue University, Indianapolis, IN; (3) Department of Pediatrics, Sleep Medicine Section, University of Chicago, Chicago, IL; (4) Department of Radiology, Brown Cancer Research Center, University of Louisville Applying the nanotechnology to the Nutraceutical products and providing drug delivery systems to deliver the Nutraceutical ingredients such as minerals, vitamins and antioxidants is a novel concept and the project we have done the formulations uses this technology and we have developed a formulation with nano emulsion having globule size 300 to 500 nm. The formulation we have developed as nano emulsion Nutraceutical which is Soybean oil based emulsion with several ingredients including milk protein, flavor, vitamins, preservatives and antioxidants. We will determine the efficacy and toxicity of the Nano emulsion Nutraceuticals formulation containing antioxidants developed in Sullivan University College of Pharmacy. Antioxidants have shown promising and beneficial applications in neuro protection in neurodegenerative diseases like Alzheimer’s

disease, Parkinson’s disease, Stroke disabilities, ALS (amylotropic lateral sclerosis). Study the cellular toxicity of Nano emulsion Nutraceutical formulation using hepato‐cytes (HepG2 cells) We will also study the Neurotoxicity of Nano emulsion Nutraceutical formulation using neuro‐blastoma cells. The Nutraceutical formulation will be administered to small animals such as rats for toxicity study. We will also look at evaluating the effect of Nano emulsion Nutraceutical formulation administration to Alzheimer’s mouse models to study the impact of antioxidants delivered as nano‐emulsion on neuro‐transmitter and pathology/histology of the brain cells. The work will be conducted in collaboration with IUPUI and University of Illinois and Bio‐imaging studies will be done at University of Louisville. 31. CENTERA Bringing New Courses in Nanotechnology for High School Faculties and Students in Common wealth of Kentucky Yashwant Pathak and Hieu Tran* Sullivan University College of Pharmacy Center for nanotechnology Education, research and Applications is a project of Sullivan University College of Pharmacy in Louisville, in Kentucky. CENTERA will help in creating future work force for growing nanotechnology companies and institutes across the United States. CENTERA will provide for education and will create intellectual property. CENTERA is developing a graduate program in nanotechnology. CENTERA is planning to provide opportunity for research in nanotechnology and applications. CENTERA will do contract research for industry. CENTERA will be addressing the needs of the community. CENTERA is proposing courses it will offer to high school students from the commonwealth of KY to create workforce ready to work in the field of nanotechnology. CENTERA had organized a course for the High school teachers at Louisville and will be offering certificate course in nanotechnology teaching for high school teachers soon. Present poster discusses various aspects of CENTERA and the proposed courses it is planning to offer from next year.

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32. Comparison of tHDA and Conventional PCR for Detection of Leptospira in Horse Urine Sergey C. Artiushin* and John F. Timoney Gluck Equine Research Center, University of Kentucky Equine abortion and uveitis caused by Leptospira interrogans are common diseases of horses in N. America. Control of the infection relies on both antibiotic therapy and management measures based on identification of seropositive animals and detection of leptospira in urine and other body fluids. Although PCR has been shown to be the most rapid, specific and sensitive method for detection of leptospira, the requirement for expensive equipment limits its application. The objective of this study was to develop and evaluate an instrument free tHDA assay for pathogenic Leptospira spp. Primers and probes for tHDA were designed using sequences of a multicopy insertion element specific for strains of different serovars of L. interrogans. The assay detected DNA’s from pathogenic but not saprophytic leptospira. The tHDA in combination with colorimetric lateral flow detection of amplicon using a disposable cassette detected as little as 5 pg of leptospira DNA. Evaluation of tHDA for detection of leptospira in horse urine revealed a specificity equal to that as PCR. Sensitivity of tHDA (50% of specimens) is inferior to that of nested PCR (63%) but greatly exceeds that of single step PCR (13%). A tHDA based assay that requires only simple equipment and minimal training of personnel is a practical alternative to PCR for rapid detection of leptospira in clinical samples. 33. Using Calmodulin to Probe the Role of Intrinsic Disorder in Biomolecular Recognition Trevor P. Creamer*, Meghan Hamilton, Serge Cardinali, and Julie Rumi‐Masante Center for Structural Biology, Department of Molecular and Cellular Biochemistry, University of Kentucky Intrinsically disordered regions (IDRs) within proteins are common and often involved in important biological functions such as transcription, signaling pathways and the immune

system. IDRs can function by undergoing a disorder to order transition when bound by another protein. It has been hypothesized that disordered binding regions have evolved in order to partially decouple binding specificity from affinity. An important system that appears to take advantage of this disorder‐mediated decoupling is calmodulin (CaM) and its binding targets (CaMBTs). When CaM binds, it induces, in most cases, alpha‐helical structure in the disordered CaMBT. We are using this system to test the hypothesis that disorder partially decouples specificity from affinity. Under this hypothesis specificity is determined by the residues that directly contact CaM. Affinity is determined in part by the propensity for the unbound CaMBT to adopt alpha‐helical structure. We can modulate the alpha‐helicity of CaMBT peptides by changing flanking residues in the CaMBT, thereby altering the affinity without changing specificity. The extent to which we have altered the alpha‐helicity of the CaMBTs can be determined using circular dichroism spectroscopy. Here we present our attempts to modulate the alpha‐helical content of a CaMBT peptide, the RS20 peptide from myosin light chain kinase, by altering flanking residues. We plan to use this system to generate the preliminary data necessary for future studies of the reasons behind Nature’s widespread use of IDRs in critical molecular recognition processes. 34. Evaluation of Recombinant Proteins of Streptococcus equi as Vaccine Components De Negri, Rafaela*, Artiushin, Sergey C., Fettinger, Mike, and John F. Timoney Gluck Equine Research Center, University of Kentucky, College of Agriculture, Veterinary Science Department Equine Strangles caused by Streptococcus equi is an important and prevalent disease throughout the world. Commercially available vaccines designed to elicit serum antibody responses alone are of low efficacy. Live vaccines have superior efficacy but have safety concerns. Our recent studies of susceptible and immune horses have suggested that acquired immunity is expressed in the tonsil and involves a combination of antibody and local cell mediated responses, We have identified several

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genes encoding immunoreactive surface and secreted proteins expressed during infection (Timoney et al.,2007). Among these proteins, SeM, Se 44.2, Se 75.3, Se 42.0, Se 110.0, Se 18.9, and IdeE showed strong reactivity when tested with a pool of convalescent horse sera and therefore were selected to test for efficacy as vaccine components. A group of 8 yearling ponies was immunized subcutaneously with this pool of proteins in combination with the potent Th1 type adjuvant Quil A.A second group was immunized intranasally with a fusion protein consisting of tonsil binding Se18.9 fused to the N‐terminal sequence of SeM. A control group was inoculated with adjuvant only. Vaccine induced immunity was evaluated by commingling vaccinated animals with 2 ponies infected with virulent S. equi CF32 and comparing the frequency and severity of strangles in the control and vaccinated groups. Antibody levels were measured by ELISA before vaccination, at commingling challenge, and after all sick ponies had recovered. Intranasally vaccinated ponies had a lower incidence of strangles and mounted stronger antibody responses compared to subcutaneously vaccinated and control ponies suggesting the tonsillar complex plays a key role in acquired resistance to S. equi and that this resistance requires local stimulation. 35. Molecular Identification of Interaction Pathways Between Carabid Beetles and Slugs in Alfalfa Mark K. Adams*, Eric G. Chapman, James D. Harwood Department of Entomology, University of Kentucky Global trade facilitates the intercontinental movement of cargo and thus increases the potential introduction of exotic gastropods to new areas of the world. Hence, there is a growing need to understand ecological interactions of newly introduced species with the native fauna. Furthermore, exotic slugs are of particular concern because yield losses to commodities planted throughout much of the continental United States are high and states such as Kentucky, whose humid climate typically supports a high density of these species, have significant acreage of farmland

planted to crops at risk of damage including alfalfa, soybean, wheat and corn. Given these concerns, and the high density of endemic natural enemies inhabiting these agroecosystems, it is essential to examine the mechanisms of predation, decipher the strength of interaction pathways and evaluate the role of predators in biological control. In 2008, over 1,000 specimens of three species of ground beetles (Carabidae) were collected from alfalfa and screened by polymerase chain reaction using species‐specific primers to identify the presence of DNA of the exotic slug Deroceras reticulatum. Feeding trials indicated that slug DNA was detectable in predator guts for approximately 12 h and, significantly, during the month of June, 5% of Harpalus pensylvanicus, 25% of Scarites quadriceps and 5% of S. subterraneus specimens screened positive for D. reticulatum DNA. Drought conditions thereafter likely caused slug predation rates to decrease as their availability to epigeal predators declined. This research has enhanced our understanding of complex and emerging slug‐carabid interactions in North America and provides a valuable framework for future efforts in conservation biological control. 36. Microfluidic Cell Arrays for High‐Throughput Culture Mai‐Dung Nguyen, Kranthi Kumar Bhavanam, Awdhesh Kalia, Yongsheng Lian and Palaniappan Sethu* Department of Bioengineering, Department of Mechanical Engineering and Department of Biology, University of Louisville Microfluidic Cell Arrays (MCAs) offer a scalable platform for highly parallel integration of cell culture with multiple and complex stimuli. However, their application for cell‐based studies is limited due to restrictions on types of cells that can be cultured within these arrays and dependence on microscopy based techniques or secreted factors for evaluation. Towards accomplishing our long‐term goal of universal cell culture, we have deconstructed the existing cell culture array to exploit benefits of automation via high‐throughput microfluidics and maintain elements of simplicity from manual manipulation for cell seeding and

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evaluation. To date we have designed a prototype 4 X 4 array to study pH and lipid gradients along with time dependent delivery of chemokines in AGS cells infected with different strains of Helicobacter Pylori (Hp). This array consists of a gradient generator and flow encoded switch to provide concentration and time dependent signals. AGS cells have been cultured and infected with Hp within the array and mRNA has been reliably isolated and shown to be consistent across the array. We are in the process of subjecting the cells to pH and lipid gradients as well as time dependent stimulus. 37. Development and Deployment of a Nontoxic Endophyte in Tall Fescue for Forage Christopher L. Schardl* (1), and Timothy D. Phillips (2) (1) Department of Plant Pathology, University of Kentucky; (2) Department of Plant and Soil Sciences, University of Kentucky Tall fescue is the most widely planted forage grass in the United States, and a key pasture component in Kentucky. Its exceptional stress tolerance, stand longevity and productivity are largely attributable to the seed‐transmitted, mutualistic symbiont (endophyte), Neotyphodium coenophialum. However, common strains of N. coenophialum produce ergot alkaloids that cause toxic symptoms in grazing livestock. The resulting fescue toxicosis causes close to $1 billion annual loss to U.S. livestock production. These anti‐mammalian effects also impact ecological succession, posing environmental concerns, for example in reclaimed strip mines. Some nontoxic endophytes have recently been deployed in tall fescue cultivars, but may be less beneficial or less compatible with the plant. The ideal strain of N. coenophialum for tall fescue cultivars would confer the key benefits to the grass but would not produce ergot alkaloids. Toward this end, we identified the gene, dmaW, for the first step in ergot alkaloid biosynthesis, and determined that N. coenophialum has two active copies. We eliminated one dmaW copy by replacing it with a foreign marker gene. Furthermore, to obviate public and regulatory concerns, we developed and successfully tested a method to

eliminate the foreign marker gene. We propose to apply these techniques to eliminate the second dmaW copy, and generate a non‐ergot alkaloid endophyte with no foreign genes in the genome. Then, we will establish this modified endophyte in elite tall fescue breeding lines to develop new cultivars, and raise seeds of these cultivars to test their agronomic traits and suitability for pastured livestock. This approach is also applicable to other temperate forage grasses worldwide. 38. Maximizing Collection and Minimizing Risk: Does Vacuum Suction Sampling Increase the Likelihood for Misinterpretation of Food Web Connections? Eric G. Chapman*, Susan A. Romero, and James D. Harwood Department of Entomology, University of Kentucky Molecular tools that characterize the structure of complex food webs and identify trophic connectedness in the field have become widely adopted in recent years. However, characterizing the intensity of predator‐prey interactions can be prone to error. Maximizing collection success of small, fast‐moving predators with vacuum‐suction samplers has the potential to increase the likelihood of prey DNA detection either through surface‐level contamination with damaged prey or direct consumption within the sampling device. In this study, we used PCR to test the hypothesis that vacuum‐suction sampling will not cause an erroneous increase in the detection of “predation” thereby incorrectly assigning trophic linkages when evaluating food web structure. We utilized general (1) Aphidoidea and (2) Collembola primers to measure the predation rates of Glenognatha foxi (Araneae: Tetragnathidae) on these prey collected by hand versus those sampled with a vacuum‐suction device. With both primer pairs, there was no significant increase in predators screening positive for prey DNA when sampled by vacuum‐suction versus those predators collected, in parallel, by hand. These results clearly validate the application of vacuum suction sampling during molecular gut‐content analysis of predator‐prey feeding linkages in the field. Furthermore, we found no evidence that predation was occurring

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inside the suction sampler because specimens collected were never observed to be feeding, nor did they screen positive at greater frequencies than hand‐collected individuals. Therefore, it can be concluded that the use of vacuum suction sampling devices (in this case a Modified CDC Backpack Aspirator Model 1412) is suitable for molecular gut‐content analysis. 39. Fully Biodegradable Polymersome‐Encapsulated Hemoglobin as a Novel Nanoparticle‐Based Oxygen Therapeutic Gautam Pangu* (1), Peter Ghoroghchian (2), Eric Ostertag (3) Vindico Pharmaceuticals Vindico Pharmaceuticals is developing NanoHeme, an advanced cellular hemoglobin‐based oxygen therapeutic that will be the world’s first suitable artificial blood substitute. NanoHeme utilizes Vindico’s proprietary nanoparticle‐based delivery platform known as the polymersome. Polymersomes are synthetic polymer vesicles formed in nanoscale dimensions and have previously been shown to efficiently encapsulate oxygen‐carrying proteins such as hemoglobin. Vindico’s lead NanoHeme formulation is synthesized from FDA approved and completely biocompatible and biodegradable polymeric building blocks. NanoHeme demonstrates all the characteristics of the ideal oxygen therapeutic, including tunable oxygen binding capacity, uniform and appropriately small size distribution, human bloodlike viscosity and oncotic properties and ease of mass production and affordable storage. Versatility of polymersome architecture allows for easy manipulation of its in vivo pharmacokinetic profile to enable optimized oxygen delivery. Notably, NanoHeme exhibits several advantages over other cellular Hb‐based oxygen carriers under development, such as improved in vitro chemical stability, augmented in vivo bioavailablity and prolonged blood circulation half‐lives in addition to its complete and safe in vivo degradation. Thus, NanoHeme is poised to alleviate the current US and worldwide blood shortages by offering the first suitable artificial blood substitute. It will result in tremendous cost saving for transfusion centers and

will obviate problems associated with donated RBC transfusions. NanoHeme will have a market in excess of $1 billion per year in the United States and its development will result in significant new job creation and regional economic stimulus. 40. An Intergrative Approach to the Study of Animal Personality Matt Druen*, and Lee Dugatkin Department of Biology, University of Louisville Personality is defined as stable behavioral differences between individuals across time or contexts, and can be measured along such axes as exploration, risk taking, and sociability. Personality traits may affect fitness through their effects on reproduction, survival, and dispersal. We will conduct a series of experiments using Poecilia reticulata, in order to assess environmental, genetic, and social factors that affect how behavioral variation within and between individuals is generated and maintained. Using a comparative approach, a controlled breeding design, and multivariate analyses, we will collect longitudinal data on personality in two populations of Poecilia reticulata that live along a predation gradient: data collected will include a range of behavioral, hormonal, and neurological traits. This project will broaden our ability to predict how individual differences arise both within and between populations, and will provide new information about how complex traits that function across a range of conflicting situations respond to environmental and developmental challenges. Our research will introduce a new model system to the area of personality research, and will help to unite diverse disciplines through the integration of proximate mechanisms and evolutionary outcomes. 41. A Non‐Invasive Method for Diagnosis of Obstructive Sleep Apnea Saeed A. Jortani* (1), and Fidaa Shaib (2) (1) Department of Pathology and Lab Medicine, University of Louisville; (2) Department of Pulmonary and Critical Care, University of Louisville

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Obstructive Sleep Apnea (OSA) is a syndrome primarily diagnosed by an overnight sleep study. This practice is burdensome, expensive and relatively unavailable to many patients. Diagnosis of OSA in snoring children should be done in a timely manner to assure a more rapid intervention. This is important since many undesirable effects of OSA can be reversed by surgical therapy in children. Several studies have previously shown that OSA is associated with inflammation and stress. We have shown that measurement of urinary markers of stress especially urocortin 3 (UCN3) in the first morning void urine is diagnostic of OSA. Our current project involves further optimization of our ELISA assay for UCN3 and to transfer our immunoassay on an automated ELISA platform. We will then assess if the concentration of UCN3 in urine collected prior to and after sleep are both diagnostic for OSA in children. The business activities will include development of a commercialization plan, market opportunity assessment and to find contacts in the in‐vitro diagnostic industry for further development of the test and its commercialization. This Commercialization Fund has begun the process of developing a clinical diagnostic test for OSA which is non‐invasive and could potentially be available in a larger scale worldwide. It will help assigning snoring children into their appropriate OSA versus habitual snoring categories in a more rapid and less expensive manner. 42. Reuse Technology at a Wastewater Treament Plant for Aquaculture Michael Wilhelm*, Richard J. Onders and Steven D. Mims Aquaculture Research Center, Kentucky State University Reuse of existing facilities that can be retrofitted for aquaculture, such as decommissioned wastewater treatment plants, could be an option. With better methods for processing wastewater, many municipalities are now building new, larger facilities, and decommissioning the old ones, many of which include sedimentation ponds and tanks that could be converted for fish culture. Many are being needlessly demolished, when recycling them

as fish hatcheries could save the community demolition costs, create new jobs and generate revenue. These old urban facilities could provide a reliable system for intensive fish culture and provide ready access to markets and lower transportation cost. Most of the new facilities are being built adjacent to the old, and would conveniently allow the treated wastewater effluent to be reused for fish culture. An experiment was conducted to evaluate the growth and survival of paddlefish using treated wastewater effluent either in a static or flow‐through system over a period of 120 days. Eight 5600‐L conical plastic tanks were stocked with 100 phase I paddlefish. The experimental tanks were divided into two treatments: static in which 50% of the water was replaced weekly, and flow‐through, in which effluent water was flowing continuously at a rate of 15L/min. Fish were fed daily to satiation with a 35% extruded prepared diet. After 120 days, fish were weighed and counted. Further, fish were sampled at the start and the end of the experiment, frozen and analyzed for various contaminants that could be perceived as unsafe for humans. Results and the use of a decommissioned wastewater treatment facility for aquaculture will be discussed. 43. Numerical Investigation of Aerodynamics of a Corrugated Airfoil Kyle Hord*, Yongsheng Lian Department of Mechanical Engineering, University of Louisville Previous experimental studies on static, bio‐inspired corrugated wings have shown that they produce favorable aerodynamic properties such as delayed stall compared to streamlined airfoils and flat plates at low Reynolds numbers (Re = 105). The majority of studies conducted have been carried out with scale models of corrugated dragon fly wings from the Aeshna Cyanea forewing in wind tunnels and water channels. Numerical simulations have also been performed. In this work we will study the aerodynamics of a corrugated wing using computational fluid dynamics method. The flow field is described by solving the incompressible Navier‐Stokes equations on an overlapping grid using pressure‐Poisson method. The equations are

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discretized in space with second‐order accurate central differences. Time integration is achieved through the second‐order Crank‐Nicolson implicit method. The discretized system of equations are then solved using the PETSc package. The corrugated wing will be then compared to a streamlined SD7003 airfoil and a flat plate. The flow fields, particularly the vortex structures that form in the corrugated wing valleys and around the corrugated wing will be studied. It has been hypothesized and demonstrated the favorable properties the corrugated wing produces compared to streamlined airfoils is caused by these vortex structures. 44. Multi‐Physics Simulation of a Coulter Counter Device Kyle Schmidt*, Yongsheng Lian Department of Mechanical Engineering, University of Louisville I am working in conjunction with Cindy Harnett and Adrian Fletcher on developing a microfluidic flow cytometer. My portion of the project is to use Computational Fluid Dynamics (CFD) to numerically analyze a microfluidic cytometer. By using computer aided CFD analysis we will be able to optimize the flow rate of the microfluidic cytometer. This optimization will allow maximum diffusion of the fluid containing diseased cells. When there is maximum diffusion within the cytometer the concentration is at a maximum; ultimately giving the best electrical impedance signal. The CFD analysis will also be used to show the heat transfer effects of a diseased cell after being treated with a heat source. HUMAN HEALTH AND DEVELOPMENT 45. Cigarette Smoke Extract Enhances the Effect of Ambient Ultrafine Particle on Endothelial Cells Yiqun Mo, Rong Wan, David J. Tollerud, Qunwei Zhang* Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville

Our previous studies have shown that ambient ultrafine particles (UFPs) may pass from the lungs to the circulation because of their very small diameter, and induce lung oxidative stress with a resultant dysfunction of lung endothelial cells. A number of epidemiological studies have shown that cigarette smoke induces cardiovascular diseases. However, no studies have addressed the potential combined effects of UFPs and cigarette smoke on vascular endothelial cells. We hypothesize that co‐exposure to UFPs with cigarette smoke extract (CSE) may cause activation of endothelial cells and dysfunction of the endothelium by oxidative stress through activation of NADPH oxidase. We measured the combined effects of UFPs with or without CSE on mouse pulmonary microvascular endothelial cells (MPMVEC) obtained from wild‐type mice and gp91phox knock‐out mice, respectively, (Gp91phox is one of the key components of NADPH oxidase, which is located in the cell membrane). Our results showed that exposure of MPMVEC from wide‐type mice to UFPs, CSE or UFPs with CSEs, at a non‐toxic dose, induced reactive oxygen species (ROS) generation, increased phosphorylation of p38 and Erk1/2, and upregulation of early growth response ‐1 (Egr‐1) and IL‐6 expression. Furthermore, exposure to UFPs with CSE caused significantly increased ROS generation in MPMVEC from wide‐type mice compared to exposure to UFPs or CSE alone. Our results also showed increased phosphorylation of p38 and Erk1/2 and upregulation of early growth response ‐1 (Egr‐1) and IL‐6 expression when MPMVEC from wide‐type mice exposure to UFPs with CSE compared to exposure to UFPs or CSE alone. However, exposure of MPMVEC from gp91phox knock‐out mice did not show the above effects. Our results suggest that the UFPs, CSE, and UFPs with CSE caused activation of NADPH oxidase result in the ROS generation lead to activation of MAPKs through induced phosphorylation of p38 and ERK1/2 MAPKs and upregulation of Egr‐1. This may further result in endothelial dysfunction through production of cytokines such as IL‐6. Our results suggest that co‐exposure to UFPs and cigarette smoke causes synergistic injury to endothelial cells.

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46. Web Assisted Recovery Richard N. Cloud Kent School of Social Work, University of Louisville The KCF award funds pre‐commercialization marketing planning and programming (e.g., billings and program evaluation) required for the Web assisted recoverey (WAR) system. The WAR system creates a low‐cost structure to reduce relapse among addicted persons in the early and high risk periods of early recovery. The structure is driven by a brief (mean = 6 minute) daily inventory that elicits time spent in known risk as well as protective activities and mental states. Using these daily entries, the WAR system is designed to produce accountability, motivation, and social support for abstinence. WAR programming uses established and hypothesized mechanisms to create daily structure and manage the risk of relapse through a)the daily inventory; b) development of relapse risk prediction feedback from daily responses; d) signup and notification of multiple stakeholders supportive of abstinence. Stakeholders are notificed on three conditions: i) failure to complete a daily inventory, ii) admission of using drugs or alcohol, and iii)responses to daily entries suggest heightened relapse risk. MATERIALS SCIENCE AND ADVANCED MANUFACTURING 47. Predictive Synthesis of Mesoporous Silica with Isolated Titanium Sites with Mixed Surfactants Stephen E. Rankin*, M. Shahidur Rahman and Rong Xing Department of Chemical and Materials Engineering, University of Kentucky The synthesis of mesoporous silica with isolated, tetracoordinated titanium sites has been acheived in thin films and bulk powders. Mesoporous silica offers advantages over conventional titanosilicate molecular sieves such as the zeolite TS‐1 due to their large pore size, which allows catalytic reactions to be performed for large reactants. The hypothesis tested in this project is that by understanding the lyotropic liquid crystalline phase

behavior of mixtures of sugar‐based surfactants and cationic surfactants in water, we could predictively synthesize metal oxide materials with the same structure by replacing water with the equivalent volume of oxide by solution‐phase synthesis. Complexation between titanium precursors and the sugar headgroups of one surfactant was also hypothesized. 48. Development of Shape Memory Materials for Aerospace and Biomedical Applications Haluk Karaca* (1), Gurdish Ded (1), Sayed Saghaian (1), Burak Basaran (1), Mohammad Souri (1), Kevin Wieman (1), Ronald Noebe (2) (1) Department of Mechanical Engineering, University of Kentucky; (2) NASA Glenn Research Center Shape memory materials are an important class of smart materials with the ability to recover mechanically induced strain with a change in temperature or magnetic field and tunable material properties (e.g. Young’s modulus, damping properties). They have the ability to sense the changes in environment and respond accordingly. They simplify products, add features, improve performance, and increase reliability with relatively little mechanical complexity. Shape memory alloys have remarkable material properties such as they can produce very high actuation strain (4‐10%), stress (~100‐400 MPa) and work output (~10 MJ/m3) as a result of reversible martensitic phase transformations. Shape Memory Polymers (SMPs), are polymeric smart material that have the ability to return from a deformed state (~100%) to their original (permanent) shape induced by an external stimulus (trigger), such as electric, temperature, magnetic field, light or solution. In this poster, results from the thermomechanical characterization of the shape memory and material properties of developed SMAs and SMPs for aerospace and biomedical applications will be presented. 49. Nanoporous Template Based Fabrication Approach to Solar Cells and Sensors

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Vijay P Singh, Suresh Rajaputra*, Raghu Mangu, Piao Liu, Sai Guduru, Bhavananda Reddy Nadimpally, Srikanth Durgamohanty Center for Nanoscale Science and Engineering, Department of Electrical and Computer Enginering, University of Kentucky Nanostructured materials have recently attracted a great deal of attention due to their tunable optoelectronic properties depending on their size, shape and aspect ratio. Nanoporous templates consisting of ordered pore arrays with controllable diameter, spacing and aspect ratio, provide an ideal platform for nanotube and nanowire based device fabrication. These templates can be filled with semiconductor nanowires and nanotubes for solar cell and sensor applications. In particular, nanostructured solar cells offer two advantages (i) size dependent quantum confinement in inorganic semiconductors and (ii) a short path to hetero‐interfaces resulting in higher short‐circuit currents and higher efficiencies in organic semiconductor solar cells. Nanostructured gas sensors benefit from high surface area, controllable wire/tube diameter and spatial density. Our recent work has focused on nanoporous template approach to fabricating nanowire/nanotube based solar cells and gas sensors. Results on device fabrication and characterization will be presented. 50. Development of Nanospring‐Based Device for Quick Remote Diagnostics by Analysis of Chemical Compounds in Human Breath Landon Oakes, Nicholas Wright*, Derrek Igleheart*, and Vladimir Dobrokhotov Applied Physics Institute, Department of Physics and Astronomy, Western Kentucky University As human breath analysis further develops as a multi‐disciplinary field, it is clear that sensor development, instrumentation systems and algorithms play critical roles within this research area. Although much emphasis in the last decade has focused on breath biomarker compound identification and physiological relevance, we increasingly turn our attention towards portable, fieldable sensor platforms for non‐invasive breath monitoring. In the human body the lungs have an

intimate relationship with the blood: as a result, many volatile compounds from all over the body can be found in the breath. Because of that people with cancer, asthma, and many other diseases carry trace amounts of distinctive biomarkers in their breath. Exhaled breath is an ideal non‐invasive medium for any diagnostic test. It is more convenient, efficient and cost‐effective than blood and urine‐based testing systems, allowing real‐time or near‐instantaneous results delivered at the point of need. Unlike blood, urine and other bodily fluids, exhaled breath is readily available for non‐invasive sampling on a continuous basis. In many ways, breath‐based testing is superior to conventional blood and urine sampling. The research was devoted to the design of an advanced chemical sensor (electronic nose) based on the novel nanomaterials – nanosprings. The device is able to determine the concentration of wide variety of chemical species especially volatile organic compounds (VOCs) – biomarkers of diseases, analyze the data using a recognition scheme, make a decision about the diagnosis, and send a corresponding signal with the condition and location of a patient to the doctor’s office. 51. A Reactor for Commercial Production of Metal Oxide Nanowires Vivekanand Kumar, Jeong H. Kim and M.K. Sunkara* Department of Chemical Engineering, University of Louisville In this poster, we will present a reactor and a gas phase production method for producing bulk quantities of metal oxide nanowires. 52. Electron‐Beam‐Induced Deposition of Metal Nanostructures from Liquid Precursors Greg Schardein*, Eugenii U. Donev, and J. Todd Hastings Department of Electrical and Computer Engineering, University of Kentucky We have developed liquid‐precursor electron‐beam‐induced deposition (LP‐EBID)‐‐a novel technique for direct‐write patterning of materials‐‐and successfully deposited metal nanostructures

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from bulk aqueous solutions of platinum (Pt) and gold (Au) precursors. Conventional EBID processes using gaseous precursors produce metal deposits of low purity (e.g., 25‐40 at.% Pt), whereas we show that LP‐EBID yields high‐throughput, high‐purity metal deposits (e.g., ~90 at.% Pt) without any post‐deposition processing. In addition, we demonstrate that LP‐EBID can produce dense arrays of small nanoparticles and nanowires that compare favorably with those typically achievable via resist‐based electron‐beam lithography. 53. Surface Interactions Between Biomolecules and Au Nanoparticles Manish Sethi* and Marc R. Knecht Department of Chemistry, University of Kentucky The binding affinity of biomolecules with nanostructures needs to be explored in more detail as the applications of these bio‐based materials are becoming more prevalent. Peptides are able to bind to materials surface and control their growth and activities based upon their amino acid sequence and geometrical arrangement. We have developed a sensitive spectroscopic and microscopic method to investigate this process employing Au nanoparticles, exploiting their vibrant optical properties. For this experiment, citrate‐capped Au nanoparticles are employed where partial displacement of the surface ligands with arginine results in a charged, patchy ligand network on the material’s surface. From this, an electronic dipole is generated, which results in the assembly of linear chains of the materials. The shape of the nanostructure and the identity of the original ligand mediate such binding events. Consequently, controlled assembly processes can occur, resulting in the fabrication of nanoparticle‐based superstructures. These results are important as they lend information to the understanding of the biotic/abiotic interface and methods to analyze such binding events. Furthermore, the prepared linear structured could be exploited as novel device components. 54. Nanoporous Nickel As an Alternative to Raney Nickel Lei Wang and T. John Balk*

Chemical and Materials Engineering, University of Kentucky The goal of this project is to develop nanoporous nickel (np‐Ni) as an alternative to Raney Ni, and also study the mechanical behavior of the nanostructured nickel. Research to date has focused on determination of optimal alloy composition and fabrication conditions for producing thin film np‐Ni. This has yielded np‐Ni with pore sizes as small as several nm. Thin films of a Ni‐Cu alloy have been deposited by magnetron sputtering and dealloyed in an etchant that preferentially removes copper. As opposed to the traditional leaching method for producing Raney nickel, this process avoids the absorption of hydrogen within the nickel pores (which makes Raney nickel pyrophoric). The optimal composition of a precursor Ni‐Cu alloy lies in the range of 30‐35 at% Ni. The finest nanoporous structure obtained so far exhibits pores 15‐20 nm in diameter, which is the same length scale as Raney Ni. However, the final composition of the nanoporous film is ~45 at% Ni (i.e. slightly copper‐rich), even though the etchant does not etch pure nickel. Future work will focus on producing higher purity np‐Ni nickel by changing the dealloying process and/or the alloy system, and then measuring the mechanical properties of np‐Ni thin films. 55. FTIR Imaging for Microscale Spatial Analysis of Hydrogel Patterning Reactions Hariharasudhan Chirra, Dipti Biswal, and J. Zach Hilt* Chemical and Materials Engineering, University of Kentucky The overall goal of this project is the development and application of a method for real‐time FTIR imaging characterization of patterning polymerization processes with microscale spatial resolution. These novel methods enable for the control and optimization of processes for the integration of intelligent polymer networks with silicon, glass, and gold surfaces of devices with microscale control. The ability to optimize the integration of these polymers is critical for the fabrication and development of platforms that

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harness the unique abilities of intelligent polymer networks, including diagnostic devices, therapeutic devices, tissue engineering, microarray, and diagnostic and therapeutic clinic‐on‐a‐chip. In these studies, the micropatterning reactions of intelligent polymer networks, which are entirely synthetic and tailored to have various properties and function, have been characterized and optimized for integration as functional components of microdevices. The specific objectives of this project have been to develop a novel method based on FTIR imaging to characterize the patterning polymerization reaction kinetics of intelligent polymer networks on silicon, glass, and gold substrates with microscale spatial resolution, characterize the polymeric networks post‐polymerization to determine their physical and response properties (AFM, SEM, etc. analysis at micro‐ and nanoscale) to develop correlations to reaction conditions, and then optimize microscale polymerization reactions (e.g. micropatterning) to allow for the reproducible and controlled integration of intelligent polymer networks with silicon, glass, and gold surfaces in microdevices. 56. High‐Resolution Pulsed‐Field‐Ionization Ion Spectroscopy of Transition‐Metal‐Oxide Clusters Lu Wu*, Mourad Roudjane, Jung Sup Lee, Changhua Zhang, Sergiy Krasnokutski, and Dong‐Sheng Yang. Department of Chemistry, University of Kentucky Transition metal oxides are widely used as both catalysts and catalyst supports in petroleum refining and other industrial processes. A catalyst is a substance that initiates a desirable chemical reaction or speeds up a reaction that would otherwise be too slow to be economical. However, catalyst development is still carried out by try and error, and the rational design of new catalysts with predictable properties is a long‐term goal requiring both basic and applied research. This KSEF‐sponsored project focuses on the fundamental aspects of the catalyst development. We use laser‐assisted synthesis to prepare metal oxide clusters in gaseous supersonic jets, mass spectrometry to measure the oxide abundance and distribution, and high‐resolution pulsed‐field‐ionization ion

spectroscopy to search for electronic‐vibrational spectra. The outputs of this research include accurate ionization and vibrational energies, electronic states, and geometric structures. The project expands our research program in a new direction, stimulates additional research in cluster science, and increases the basic knowledge about the size‐dependent properties of the transition metal oxide clusters. This work opens up new area for high‐resolution ion spectroscopic applications to transition metal clusters and enhances Kentucky’s emerging international reputation in this field. With the preliminary results from this grant, we have already obtained additional one hundred thousand research dollars from the Petroleum Research Fund of the American Chemical Society and presented several papers at national and international meetings. With this grant, we are training several graduate and postdoctoral students in modern physical chemistry and chemical physics. 57. Microwave Assisted Synthesis of SAPO‐34 Molecular Sieves by Phase Transformation of SAPO‐5 Surendar R. Venna*, Moises A. Carreon Department of Chemical Engineering, University of Louisville SAPO‐34 zeolite displaying ~0.5µm crystal size with narrow particle size distribution and preferrential CO2 adsorption over CH4 was prepared via phase transformation of SAPO‐5 under microwave heating. The short synthesis time, smaller crystal size and narrow particle size distribution of the synthesized SAPO phases, make these materials attractive for the potential preparation of the thinner membranes for CO2/CH4 separation. 58. Selectively‐Stimulated Self‐Assembly of Polymer Thin Films into Nanometer‐Scale Air‐Bridges and Suspended Membranes Jeremy M. Rathfon *, Pavan K. Putcha, and Robert W. Cohn ElectroOptics Research Institute and Nanotech‐nology Center, University of Louisville A new approach toward the fabrication of oriented,

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suspended polymer nanometer‐scale fibers and structures has been developed. Nanometer‐scale "air‐bridges" can be selectively patterned by using a focused laser to anneal thin films atop lithographically fabricated arrays of pillars. Gradient thickness, ultra‐thin polymer films, from ~ 20 to 1000 nm in thickness, are cast using flow coating. The films are then transferred via floating onto micropillar arrays. A specific pattern of holes is melted into the suspended film by a highly focused laser through the use of both a rapid laser scanner and a controlled motion stage. The film written with patterned holes is then annealed above the Tg of the polymer, whereupon the holes undergo expansion, impinge upon each other, and form suspended "air‐bridges" or other designed nanostructures, suspended between pillars. Precise control of this film annealing step allows for tailoring of the dimensions of the resulting nanostructures. To date, holes have been selectively patterned in desired arrangements into ultra‐thin films by annealing with a laser. These holes have been systematically annealed to form designed architectures, such as both linear and orthogonal suspended fibers, with controlled heating in order to better understand the hole expansion and fiber drawing processes. The nanostructures fabricated with this laser annealing technique have potential for use in device applications in nanoelectronics, microelectromechanical systems (MEMS), optical sensors, and nano‐optics. These applications require the ability to fabricate fibers with regular diameters, structure, and orientation, in specific two and three‐dimensional architectures with point to point connections. 59. Market Development and Manufacturability Scale Up of Nanoneedle Probes Sreenath Arva (1), Mehdi M. Yazdanpanah (1,2*), and Robert W. Cohn (1) (1) ElectroOptics Research Institute and Nanotech‐nology Center, University of Louisville; (2) NaugaNeedles LLC The purpose of this KCF award is to commercialize the UofL‐developed invention of self‐assembled metallic nanowires (referred to as “nanoneedles”).

The study focused on market assessment and manufacturing rate improvements. Marketing assessment included presenting the technology at trade shows at major scientific conferences and providing custom evaluation samples (under material transfer agreements) to over 40 interested customers. Studies by these customers with these evaluation samples have already resulted in 10 research reports at national conferences and peer reviewed journals. Also during this time, the inventors filed for a patent on the fabrication and several applications of the technology. Based on these pre‐commercialization activities by UofL, the company NaugaNeedles licensed the invention, obtained an international distributor, and began manufacturing and selling devices based on this technology. Since September, when MMY joined NaugaNeedles full time, his company has sold devices to over 75 labs around the world, won two Phase I SBIRs to further develop the technology, won a Vogt Award and was awarded a Kauffman Foundation Entrepreneurial Postdoctoral Fellowship. The manufacturing milestone for this project (just completed in March) was to fabricate the nanoneedles in parallel using a batch fabrication procedure that is compatible with semiconductor device manufacturing methods. Experiments from the study were used in the NSF Phase SBIR I proposal by NaugaNeedles and UofL that demonstrated potential for batch fabrication. This NSF study is now working on an innovative approach that is expected to demonstrate feasibility of batch fabrication with high yield and uniformity. 60. High Performance Materials for Structural Repair Issam Harik*, Abheetha Peiris, Drew Thompson Department of Civil Engineering, University of Kentucky The “High Performance Materials for Structural Repair” project will develop and test a new product made from high strength carbon fiber strips to strengthen and upgrade existing reinforced concrete and steel bridges and buildings. The primary advantage of this new technology lies in its high strength to weight ratio (more than five times

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stronger than steel and a quarter of the weight of steel by volume), its minimal requirement for construction equipment, and its ease and speed of application by a single worker, thus reducing the cost of strengthening and upgrading structures. 61. Development of Advanced Welding Technologies YuMing Zhang*, Xiangrong Li, Jinsong Chen, Zeng Shao, Kun Qian, Yi Lu, and Chenglin Yi Adaptive Intelligent Systems LLC Adaptive Intelligent Systems (AIS) develops and commercializes cutting edge welding technology. This presentation outlines development efforts for three innovative welding technologies: 1) a modified GMAW process which reduces heat input and improves throughput; 2) a state‐of‐the‐art pipe welding system which allows welders with minimum skills to produce quality welds and 3) a technology for the monitoring of the arcing conditions including presence and size of areas with poor surface conductivity, the geometry of the joint and possible arc deviation. 62. Alpha Alumina Moisture Sensors for Trace Moisture Measurement Zhi David Chen Department of Electrical Engineering, University of Kentucky For trace moisture or dew point measurement, Currently the major sensors on the market are aluminum oxide moisture sensors with a range of ‐100C ‐ +20C dew point. The major drawback of the current sensor are their long term drift. The major reason for the long term drift is that the aluminum oxide is amorphous, which is unstable when it reacts with moisture. The author developed an alpha phase aluminum oxide film moisture sensors. Because of the super stability of alpha‐aluminum oxide, this sensor exhibits long term stability without drift. 63. Pure Particle Method for Fluid‐Structure Interaction Applications in ASTE‐P Toolset Patrick Hu, Ramji Kamakoti*, Zhen Wang, and Liping Xue

Advanced Dynamics Corporation, Lexington Advanced Dynamics has developed a comprehensive and integrated software toolset, ASTE‐P, for mutidisciplinary, multiphysics, multiscale and multifidelity analysis and design optimization (4MAO) of aerospace vehicles, and the module of pure particle method (PPM) is one of the key modules in ASTE‐P for fluid‐structure interaction applications. PPM is similar to the Smooth Particle Hydrodynamic (SPH) method in a sense that the solutions are solved on the particles. But unlike SPH, instead of a kernel function, PPM uses least square technique to interpolate properties to the particles. PPM can handle complex fluid flows and it is also very convenient to treat the fluid‐solid boundaries, thus making it a very powerful method for solving fluid‐structure interaction and aeroelastic problems. This novel method has no numerical diffusion and avoids the time‐consuming grid generation for complex geometries and mathematically solving the fluid and structure compatibility as well as time‐synchronization problems that are typically encountered by standard CFD/CSD coupling approaches for fluid‐structure interaction, leading to the best accuracy and computational efficiency achievable. More importantly, the particle‐based method allows for computing the geometrically nonlinear structure dynamics (i.e. large structure/control surface deformations and/or motions) in the natural and efficient way because particles can freely move. It is an innovative approach that offers significant more advantages than conventional methods. 64. Material Point Method ‐ A Unified Solver for Nonlinear Aeroelasticity and Fluid‐Structure Interactions in ASTE‐P Toolset Patrick Hu, Liping Xue*, Ramji Kamakoti, Kun Qu, and Qingding Li Advanced Dynamics Corporation, Lexington Advanced Dynamics has developed a comprehensive and integrated software toolset, ASTE‐P, for mutidisciplinary, multiphysics, multiscale and multifidelity analysis and design optimization (4MAO) of aerospace vehicles, and

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the module of particle method is one of the key modules in ASTE‐P for fluid‐structure interaction (FSI) applications. The FSI is numerically challenging. In our implementation, the Material Point Method (MPM) is extended and enhanced to solve both fluid and structural dynamics, leading to an innovative unified solver for modeling and simulation of nonlinear aeroelasticity and fluid‐structure interactions. In our approach, the fluid and structure are discretized in a single computational domain, and a unified solver is used to solve both fluid and structural dynamics, but with different EOS. The FSI are modeled by momentum exchange at the interface via the computational background grid. To eliminate the numerical oscillations that are typically encountered by particle‐based methods, a minmod‐type slope limiter is adopted. The distortion of the material point distribution is solved by regularization. Adaptive multi‐level mesh refinement (AMR) algorithm is developed to capture the multi‐scale physics. To speed‐up the calculation, parallelization is implemented. Preliminary results indicate that MPM with dynamic AMR can be a powerful tool to simulate FSI/aeroelastic problems for aerospace vehicles. 65. Three‐Dimensional Fatigue Crack Growth Prediction of Surface Crack on Ti Tubes Kan Ni*, and Patrick Hu Advanced Dynamics Corporation, Lexington A methodology of three‐dimensional fatigue crack growth prediction of surface crack on Ti‐tubes of a rotor aircraft is developed. (1) A laser micromachining technology is developed to provide sharp notch in the specimen, consequently only crack growth stage is considered herein. (2) A three‐dimensional finite element modeling (3D FE) of surface crack is developed for various aspect ratios to calculate the J‐integral and stress intensity factor. (3) The NASGRO crack growth rate is employed to predict the 3D fatigue crack growth of surface crack on Ti tubes. (4) Normal crack, median crack, and long crack and their propagation life have been modeled successfully. (5) Predictions of fatigue crack growth life agree very well with experimental results. (6) A methodology to predict

fatigue damage limit is developed. The prediction of fatigue damage limit agrees very well with experimental data. 66. Coupled Viscous Vortex Particle Method and Unstructured CFD Solver for Rotorcraft Aerodynamic Interaction Hongwu Zhao*, and Patrick Hu Advanced Dynamics Corporation, Lexington In this investigation, a novel and efficient numerical approach for rotor/body aerodynamic interaction will be developed using the fully coupled CFD(Computational Fluid Dynamics) /VPM(Vortex Particle Method). The CFD will be solved using an Eulerian framework and it is only applied in the vicinity of rotor blades, fuselage, or ship structure surface to generate the particles and vorticity sources (location and strength) of the vortices. The evolution of these vortices will be solved using the VPM approach with a Lagrangian framework in the rest of the flow field. The VPM and CFD will then be properly combined through a rigorously formatted VPM/CFD coupling interface to render a hybrid aerodynamic modeling tool that can effectively address the rotor/fuselage and rotor/ship mutual interaction problem. The hybrid VPM/CFD tool thus developed will prevent the rotor wake vorticity from dissipating in a non‐physical and excessive way via robust VPM simulation, and also will be computationally very efficient as the unstructured CFD solver will be only applied to the near the body surface regions. The efficiency and accuracy of the hybrid VPM/CFD method will be demonstrated with two test cases: NACA0015 wing and ROtor and Body INteraction(ROBIN) in current investigation. 67. Jet Noise Prediction Using Large Eddy Simulation and Acoustic Intensity Based Method of the ASTE‐P Toolset Nagendra Dittakavi*, and Patrick Hu Advanced Dynamics Corporation, Lexington Advanced Dynamics Corporation has developed a comprehensive and integrated software toolset, ASTE‐P, for mutidisciplinary, multiphysics, multiscale and multifidelity analysis and design

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optimization (4MAO) of aerospace vehicles, and the Computational Aeroacoustics (CAA) module is one of the key modules in ASTE‐P for flow generated noise predictions. Jet noise prediction results presented are using the ASTE‐P toolset. The aerodynamic noise generated by airplanes continues to be a critical factor in the future development of aviation. In particular, the noise radiated by the jet engine exhaust (historically called “jet noise”) has received significant regulatory attention. Specific near term noise‐reduction goals are driving research in aeroacoustics. Among several existing turbulence models, large‐eddy simulations (LES) offers the most promise in the foreseeable future for noise prediction at Reynolds numbers of practical interest. Various methods have been developed for characterizing sound sources and predicting their radiated acoustic field. The acoustic intensity based method (AIBM) considers the general solution for the Helmholtz equation which is approximated by a linear combination of basis functions. This method has been found to be very efficient compared to other popular acoustic models including Ffowcs Williams‐Hawkings integral method. Jet noise predictions using LES and AIBM techniques will be presented. 68. A Robust and Efficient Mesh Deforming Algorithm for Aeroelastic Modeling and Simulation Shouchun Deng*, and Patrick Hu Advanced Dynamics Corporation, Lexington Advanced Dynamics Corporation has developed a comprehensive and integrated software toolset, ASTE‐P, for multidisciplinary, multiphysics, multiscale and multifidelity analysis and design optimization) (4MAO) of aerospace vehicles, and the module that handles the grid deformation is one of the key modules in ASTE‐P for fluid‐structure interaction applications. Unsteady flow simulations for problems with moving boundaries such as those found in the aeroelastic simulation of wings and aerodynamic shape optimization require a fast and reliable numerical algorithm for deforming the

computational grid as the flow boundary changes. Grid regeneration at each time step in an unsteady calculation or in each design cycle is a natural choice. However, mesh generation for a complex geometry is a nontrivial and time‐consuming task, thus an automatic and fast numerical algorithm to deform an existing grid is highly‐demanded. A robust dynamic mesh deformation algorithm for aeroelastic simulations has been developed at Advanced Dynamics and integrated into ASTE‐P. This grid deformation algorithm uses a method of background grid interpolation / projection. The background grid is linear spring network with nonlinear torsional effect. In this regard, this method is similar to Farhat’s approach. However, the difference exists: the background grid is wholly independent from and much less than CFD grids which covers the same computational domain. The proposed method has also adopted Qin’s interpolation / projection idea, but the background grid in our approach only needs to be deformed rather than regeneration at each time step. Thus the proposed approach is much more efficient than both Farhat’s and Qin’s approaches. 69. Multifunctional SPIO‐Incorporated Polymer Nanodevices for Magnetothermally‐triggered Drug Delivery for Cancer Therapy Handan Liu*, and Patrick Hu Advanced Dynamics Corporation, Lexington Multifunctional nanoscale devices can play a significant role in increasing the effectiveness of the treatment while decreasing severity of side effects for cancer therapy. A SPIO (superparamagnetic iron oxide)‐incorporated Polymeric Micelle Nanodevice (SPMN) for magnetothermally‐triggered drug delivery was presented in this project. SPMN is a formulation of the multifunctional nanodevice, namely tumor‐specific targeting, magnetothermally‐triggered drug release by an AC magnetic field, and imaging sensitivity for cancer applications. SPIO nanoparticles play an important role in this theranostics not only as a heating agent for thermal trigger, but also as a contrast agent for ultrasensitive MRI detection. SPIO nanoparticles were loaded into the cores of PEGylation micelles,

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while DOX (doxorubicin) was entrapped in a thermo‐sensitive layer between the core and shell. A folate ligand was also installed on the micelle surface for cell‐specific targeting. An AC magnetic field was designed for producing heat so that PNIPAm collapses to release the drugs at the accumulated site in the body. The proposed SPMN nanodevice will be appropriately suitable for targeting drug delivery system with longer circulation time, reduced side effects and controlled drug release in response to the change in external temperature. Such theranostic nanodevice will hold considerable promise to achieve personalized therapy of cancer and to maximize the specificity and efficacy of chemotherapy. INFORMATION TECHNOLOGY AND COMMUNICATIONS 70. Multi‐Projector Multi‐Touch Display Steve Dominick*, Ryan Copple, Bill Gregory, Michael Schmidt, and Ruigang Yang Center for Visualization and Virtual Environments, University of Kentucky We present a portable multi‐touch, multi‐projector display demonstrating the scalability of both interaction and display technology. We have combined an open source multi‐touch software package with proprietary multi‐projector rapid calibration and display software developed at the University of Kentucky to create a unique multi‐user interactive experience. Unlike other interactive display technologies such as resistive or capacitive touch screens, each of these techniques can be arbitrarily scaled to any size with a nearly linear relationship of cost per square foot. As interactive multimedia expands further into the marketplace, we believe that unique display technologies such as this will be essential toward meeting the goals of content providers and enhancing the user experience in challenging display environments. 71. Integrated Variable‐Fidelity Tool Set for Modeling and Simulation of Aeroservothermoelasticity‐Propulsion (ASTE‐P) of Aerospace Vehicles from Subsonic to Hypersonic

Patrick Hu* , Liping Xue, Kan Ni , Negendra Dittakavi, Hongwu Zhao, and Ramji Kamakoti Advanced Dynamics Inc. Advanced Dynamics is under the way for development of an Integrated Variable‐Fidelity Tool Set for Modeling and Simulation of Aero‐Servo‐Thermo‐Elasticity and Propulsion (ASTE‐P) Effects of Aerospace Vehicles Ranging from Subsonic to Hypersonic Flight. The ASTE‐P software tool set is developed in the state‐of‐the‐art and commercial standard and enables accurate integration and tight/loose coupling of the fluid, structural and control field simulation with variable fidelity options available. The ASTE‐P software tool can be appli‐cable to modeling and simulation of aerodynamics, structural dynamics, flight control and propulsion dynamics as well as more important interactions of these dynamics. All flight re‐gimes from subsonic to hypersonic are covered. The interface of structural/control surface motion and vibration modes with fluid flows is modeled using either unified particle‐based methods (MPM/PPM) or FVM/FEM based tight/loose coupled fluid/structure solving algo‐rithms. Three levels of simulation environments are included in ASTE‐P tool set: (1) the bot‐tom level of high‐fidelity and full‐order simulation environment, (2) middle level of fast analysis and evaluation environment which is based upon on reduced order models (ROM) and provides fast turn‐around time, and (3) top level of rapid design and optimization envi‐ronment. In addition, various flight control systems (FCS) designs and design optimization are encompassed in the fully developed ASTE‐P software tool set. The test cases presented in this paper indicate that the functionalities of ASTE‐P are compatible or even more efficient than the similar software that is currently available. 72. Real Time Click Fraud Detection and Prevention Mehmed Kantardzic, Chamila Walgampaya*, Darren King, Sean Higgins, Brent Wenerstrom, Chris Simpson, and Joung Woo Computer Engineering and Computer Science, University of Louisville

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Click fraud is a type of internet crime that occurs in pay per click online advertising when a person, an automated script, or a computer program imitates a legitimate user of a web browser clicking on an ad, for the purpose of generating a charge per click without having actual interest in the target of the ad's link. Most of the available commercial solutions are just click fraud reporting systems, not real time click fraud detection and prevention systems. A new solution is proposed that will analyze the detailed user click activities based on data collected form different sources. More information about each click enables better evaluation of the quality of click traffic. 73. Closed System Container Wireless Monitoring Systems Ashok Kumar*, Sid Bhatacharyya, and Patrick Garrity Kentucky State University Wireless sensor technology (WST) plays a significant role in the monitoring of critical operations. WST may be employed for any “closed system” container of liquid (with or without headspace). The deployment of the WST allows in monitoring “real‐time” physical parameters (e.g. pressure, temperature, humidity, etc.) and automated remote sample collection of container’s liquid and/or headspace. The data collected can be analyzed to perform real time monitoring of the industrial processes. Development of such an integrated wireless sensor package for automated monitoring is central to the implementation of an automated response system. This automated response system is what we plan to build as our product to support monitoring the closed containers stored for long periods of time. This will save the industry the expensive and unsafe process of manual monitoring. 74. Integral Lens Arrays for On‐Tablet Pharmaceutical Anti‐Counterfeiting Daniel L. Lau Department of Electrical Engineering and the Center for Visualization and Virtual Environments, University of Kentucky

The goal of this project is to develop an inexpensive means of manufacturing holographic display devices as a security marker. Holograms, like the ones being proposed here, have long been used to protect hard copy documents such as security certificates, credit cards, or identification cards like a drivers license. Having such devices printed onto the surface of medicinal tables would similarly secure our nation's drug supply. So in this project, we will demonstrate an imaging process for forming the hologram, which will include an optics system composed of an off‐the‐shelf DLP projector for projecting the desired holographic image onto the first side of an integral lens array where the integral lens array has a light sensitive material layer spaced relative to the second side of the integral lens array. The active digital mask will allow for varying the provided image to create a three dimensional image and to account for distortions caused by the optics system or curvature in the integral lens array and light sensitive material. 75. Monitoring Runway Using Smart Sensor Networks Biswajit Panja* (1), and Siddhartha Bhattacharyya (2) (1) Morehead State University, (2) Kentucky State University Runway mishaps occur due to the lack of real time monitoring and time gap in alerting on diagnosing a severe condition. The event response time gap can be reduced by deploying automated technology to handle constant 24/7 monitoring, and alerting on severe condition detection by transmitting a warning signal. One such technology we propose is the deployment of wireless sensor network to detect errors/faults on the runway and transmit warning messages to the pilot and air traffic controller in real time. With wireless sensor network deployment, crashes like that of Comair 5191 could be avoided as the pilot would be instantly notified of the length of the runways based on the signals received from the sensors deployed on different runways in an airport. The wireless sensor network could also detect severe

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weather conditions which can go undetected by human beings thus preventing further loss of lives. 76. Software for reusing data modeling patterns Solomon Antony* Murray State University Reuse of data modeling patterns is a viable alternative to developing data models using the traditional methods. This presentation provides details of a software application for data modeling from patterns. In addition, we present results of pilot studies completed at Murray State University. Plans for data collection from other Kentucky universities and colleges are presented also." 77. Architecture Analysis of Peer to Peer Data Exchanges for Node Based Probing and Monitoring in Distribution of Contraband Material Nick Miles, Olfa Nasraoui*, Michael Losavio, Derek Reese, Carlos Rojas, Jeff Marean, Artur Abdullin, Adel ElMaghraby Department of Computer Science and Engineering, University of Louisville Unstructured Peer‐to‐Peer (P2P) networks allow for anonymous transfer of material between computers on the internet. This provides a safe haven for the illegal exchange of contraband material such as child pornography. The purpose of our project is to discover and eventually stop the persons responsible for the introduction of contraband material into an unstructured P2P network. For this aim, we adopt an approach based on data mining that is based on the analysis of network data captured by a number of probe nodes on a P2P network. Our work is validated by a series of simulations on large graphs with activities and scenarios adhering to typical P2P networks. For the validation purposes, we have created an unstructured P2P simulation platform that will allow various algorithms to be tested, allowing a methodology to be developed for discovering high profile contraband sharers. The simulator implementation is based on the gnutella 0.4v protocol. Gnutella is one of the most popular

protocols in use today by several freely available P2P network clients. The simulator will be used to evaluate various listening node placement algorithms and probing techniques to discover nodes sharing contraband. This in turn will allow us to evaluate and select the best techniques for any unstructured P2P protocol. 78. New Dental 3D Image Probe for Orthodontic Treatments Aly Farag (1), David Tasman (2), Dongqing Chen* (1), Mike Miller (1), Salwa Elshazly (1) (1) Electrical and Computer Engineering, University of Louisville CVIP Lab; (2) Dentistry, University of Louisville This project will commercialize a new dental probe which combines a small intra‐oral CCD camera with an integrated magnetic tracker, which enables the capturing of a sequence of calibrated 2D images, from which a 3D model of the visible part of the oral cavity (crowns) will be generated. Our proprietary algorithms and software further enhances the surface model using a teeth library and additional information that may be available about the subject (e.g., an X‐ray, panoramic imaging, cone‐beam CT, etc.) This automated process provides a complete 3D model of the Jaw (crown, bone, root and gum). This 3D model is suitable for various quantitative analysis of teeth movements, gum tissue characteristics and the overall health of the oral cavity. We propose to provide software to analyze and predict the proper adjustment of tooth alignment within the mouth, allowing Orthodontists Technical Assessment, to be able to reduce a teeth alignment protocol from 18‐24 months to 6‐9 months. Various dental procedures (e.g., implants, craniofacial interventions, and gum disease treatments) will be possible by this non‐invasive approach. The instrumentation system for generating these models is intended to be simple and inexpensive. The jaw model will form the basis for biomechanical studies for proper description of tooth movement, which will be very useful for alignments, implants and numerous craniofacial procedures. The model will also be useful for teaching and training of dental students and practitioners.

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CONFERENCE ATTENDEES LAST NAME FIRST NAME POSITION INSTITUTION/COMPANY EMAIL

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Adams Mark University of Kentucky [email protected]

Anderson Kristina Program Manager, Division of Bio Fuels

Energy and Environment Cabinet

[email protected]

Antony Solomon Assistant Professor Murray State University [email protected]

Antos George Program Director, Catalysis and Biocatalysis

National Science Foundation

[email protected]

Artiushin Sergey University of Kentucky [email protected]

Arva Sreenath Research Technician II University of Louisville [email protected]

Baker Chris Director, Information Technology

Kentucky Science & Technology Corporation

[email protected]

Balk T. John Assistant Professor University of Kentucky [email protected]

Banks Stan Senior Scientist AllTranz Inc. [email protected]

Barach Casey Executive Director ezone [email protected]

Baron Andre Assistant Professor University of Kentucky, Markey Cancer Center

[email protected]

Barzilov Alexander Associate Professor Western Kentucky University

[email protected]

Basaran Burak Dr./Post‐Doc University of Kentucky [email protected]

Berglund Dan President and CEO State Science and Technology Institute (SSTI)

[email protected]

Bhattacharyya Siddhartha Assistant Professor Kentucky State University [email protected]

Blake John Student University of Louisville/Simon Sounds

[email protected]

Bloemer Ken Executive Director, Plant Eureka

Merwyn Research Inc. [email protected]

Boggs Kim Coordinator of Entrepreneur Center

Ashland C&T College [email protected]

Bradley Luke Assistant Professor University of Kentucky [email protected]

Burden Robert Research Engineer University of Louisville [email protected]

Burklow Cindy COO Naprogenix, Inc. [email protected]

Burnett Jennifer Post‐Doc University of Louisville [email protected]

Carroll Jim Director Kentucky Highlands Investment Corp

[email protected]

Chapman Eric Post‐doctoral Scholar University of Kentucky [email protected]

Chen Dongqing Professor University of Louisville, CVIP Lab

[email protected]

Chen Zhi Assistant Professor University of Kentucky [email protected]


56

Cloud Richard Associate Professor University of Louisville [email protected]

Cohn Robert Professor University of Louisville [email protected]

Cornell Carol SBDC Director Northern Kentucky University

[email protected]

Cox Nancy Associate Dean for Research

University of Kentucky [email protected]

Creager Mitch Director of Accounting Kentucky Science & Technology Corporation

[email protected]

Creamer Trevor Associate Professor University of Kentucky [email protected]

Crocker Mark Senior Scientist CAER University of Kentucky [email protected]

Dai Jin Senior Scientist Four Tigers, LLC [email protected]

Daly Beverly Research Proposal Officer

University of Louisville [email protected]

Dansky Michael Principal The Brattle Group [email protected]

Daugherty Laurie Director, Venture Finance


[email protected]

De Negri Rafaela Post‐Doc (PhD candidate)


Deng Shouchun Scientist Advanced Dynamics, Inc. [email protected]

Deshpande Rutooj PhD Student University of Kentucky [email protected]

Didion Catherine Director, Committee on Women in Science, Engineering and Medicine

The National Academies [email protected]

Dittakavi Nagendra Scientist Advanced Dynamics, Inc. [email protected]

Dominick Steve Commercialization Engineer


Donev Eugenii Research Associate University of Kentucky [email protected]

Druen Matt Postdoctoral Fellow University of Louisville [email protected]

Eames Chad Executive Staff Advisor Cabinet for Economic Development

[email protected]

Ein Robert Omnitek Inc. [email protected]

Eisenberg Rod Frontier BioPharm, LLC [email protected]

El‐Baz Ayman Assistant Professor University of Louisville [email protected]

Falamarzian Arash Graduate Student GUEST ‐ University of Alberta

[email protected]

Falamarzian Mahmood Professor (Retired) GUEST ‐ Goldaro Herbal Company

[email protected]

Fannon Michael Assistant Professor University of Kentucky [email protected]

Ferrell Blaine Dean, College of Science Western Kentucky [email protected]


57

University

Fosson Mick Director, Ashland Area Innovation Center

Ashland Community and Technical College

[email protected]

Fuller Matthew Post‐Doc University of Louisville [email protected]

Garbett Nichola James Graham Brown Cancer Center, University of Louisville

[email protected]

Garrity Patrick Student Kentucky State University [email protected]

Gersony Richard President Medmovie.com [email protected]

Goodnight Jo Anne NIH SBIR/STTR Program Coordinator

National Institutes of Health

[email protected]

Graham Uschi President Topasol, LLC [email protected]

Gregory Bill University of Kentucky, Visualization Center

[email protected]

Gupta Ramesh Professor University of Louisville [email protected]

Gutierrez Julio Post‐Doc University of Kentucky [email protected]

Hall Stephen Stoll Keenon Ogden PLLC [email protected]

Hanley Carol Agric Extension Specialist


Harik Issam Professor University of Kentucky [email protected]

Heink Phil Ascension Analytical [email protected]

Herrensmith Gabrielle Post‐Doc University of Kentucky [email protected]

Hillard Jan Associate Provost Northern Kentucky University

[email protected]

Hilt J. Zach Assistant Professor University of Kentucky [email protected]

Hinds Bruce Professor University of Kentucky [email protected]

Hord Kyle Post‐Doc University of Louisville [email protected]

Hornbeck Jeremy Graduate Student University of Louisville [email protected]

Hu Patrick President and Chairman Advanced Dynamics Inc. [email protected]

Huang Chifu CEO Oraceuticals, Inc. [email protected]

Igleheart Derrek Research Assistant Western Kentucky University

[email protected]

Jackson Douglas Research Engineer University of Louisville/Simon Sounds

[email protected]

Jain Mahendra Vice President and Executive Director


[email protected]

Jayanthi Chakram Professor/Chair University of Louisville [email protected]

Jones Natasha Commercialization University of Kentucky [email protected]


58

Specialist

Jortani Saeed Associate Professor University of Louisville [email protected]

Kakar Sham Professor University of Louisville [email protected]

Kamakoti Ramji Senior Research Scientist Advanced Dynamics, Inc. [email protected]

Kantardzic Mehmed Professor University of Louisville [email protected]

Karaca Haluk Assistant Professor University of Kentucky [email protected]

Keller Bradley Professor of Pediatrics University of Louisville [email protected]

Khanal Dawadi Deepti Student Kentucky State University [email protected]

Khatri Rajesh Research Scientist Topasol LLC [email protected]

Kim Jeong Hoon Senior Scientist University of Louisville [email protected]

Kimel Kris President Kentucky Science & Technology Corporation

[email protected]

King Robert President KY Council on Postsecondary Education

[email protected]

Knapp Liz Program Manager Kentucky Science & Technology Corporation

[email protected]

Kotwal Girish Professor Sullivan University College of Pharmacy

[email protected]

Kulshrestha Manish Senior Scientist, Natural Products Chemistry

Naprogenix, Inc. [email protected]

Kumar Ashok Professor Kentucky State University [email protected]

Kumar Vivekanand Graduate Research Assistant


Kurzynske Rick Statewide Director Kentucky Science & Technology Corporation

[email protected]

Labreveux Maria Senior Program Manager R&D and Commercialization


[email protected]

Lau Daniel L. Assistant Professor University of Kentucky [email protected]

Lawson Jeramie Talon Technologies [email protected]

Li Xiangrui PhD Student University of Kentucky [email protected]

Lian Yongsheng Assistant Professor University of Louisville [email protected]

Liang Pei University of Kentucky [email protected]

Lind Allen VP of Information & Technology

Council on Postsecondary Education

[email protected]

Linville Linda Assistant VP of Academic Affairs

KY Council on Postsecondary Education

[email protected]

Littleton John CEO‐CSO Naprogenix, Inc. [email protected]

Liu Handan Scientist Advanced Dynamics, Inc. [email protected]


59

Mamaril Natasha Student/Post‐Doc University of Kentucky [email protected]

Mangu Raghu Graduate Student University of Kentucky [email protected]

Marrs Brock Vice President for Research

NuForm Materials, LLC [email protected]

Marshall R. Gary Executive Director Estern Region ICC [email protected]

Martin Nancy Professor University of Louisville [email protected]

McCord Richard President CIMPLE Technologies, Inc dba McCord‐Tech

mccord‐[email protected]

McCord James Student/Post‐Doc CIMPLE Technologies, Inc dba McCord‐Tech

mccord‐[email protected]

McGarvey Matt Vice President, Commercialization and Venture Finance


[email protected]

Meduri Praveen Graduate Research Assistant


Meyyappan Meyya Director, Center for Nanotechnology

NASA Ames Research Center

[email protected]

Miles Nicholas Post‐Doc University of Louisville [email protected]

Miller David Student University of Louisville/Simon Sounds

[email protected]

Miller James Professor Emeritus, Mathematics and Computer Science

Transylvania University [email protected]

Mims Steven Professor Kentucky State University [email protected]

Mohan Royce Associate Professor University of Kentucky [email protected]

Monks Noel Senior Scientist, Oncology

Naprogenix, Inc. [email protected]

Mooers Ian Executive Director EKU/CEDET (Center for Economic Development, Entrepreneurship & Technology at Eastern Kentucky University)

[email protected]

Moreno Monica Graduate Student University of Louisville [email protected]

Moss Kyle Electrical Engineer Western Kentucky University

[email protected]

Naber John Associate Professor University of Louisville [email protected]

Nadimpally Bhavananda Reddy

Graduate Student Department of Electrical & Computer Engineering

[email protected]

Nasraoui Olfa Associate Professor University of Louisville [email protected]

Ng Chin Associate Professor University of Louisville [email protected]

Ni Kan Principal Scientist Advanced Dynamics, Inc. [email protected]


60

O'Leary Sean Senior Director, KY New Energy Ventures


[email protected]

Ostertag Eric CEO Transposagen [email protected]

Palmer Lyn Regional Sales Manager Trinity Video Communications

[email protected]

Pangu Gautam Senior Scientist Vindico Pharmaceuticals [email protected]

Panja Biswajit Assistant Professor Morehead State University b.panja@morehead‐st.edu

Pathak Yashwant Assistant Dean of Research

Sullivan University College of Pharmacy

[email protected]

Peiris Nisal Post‐Doc University of Kentucky [email protected]

Phillips Taunya Assistant VP, Commercialization & Economic Development


Pierce William Interim Executive Vice President for Research


Polcer James Graduate Student Western Kentucky University

[email protected]

Pope Sam Assistant Professor Pikeville College, School of Osteopathic Medicine

[email protected]

Pritchard Carrie Assistant Professor Western Kentucky University

[email protected]

Puli Vijay Kumar Student Sullivan University College of Pharmacy

[email protected]

Putcha Pavan Research Assistant University of Louisville [email protected]

Quiton Jonathan Assistant Professor Western Kentucky University

[email protected]

Rai Satish NUCLEUS [email protected]

Rajaputra Suresh Senior Research Scientist


Ramadugu Hyndhavi Student Sullivan University College of Pharmacy

[email protected]

Rankin Stephen Associate Professor University of Kentucky [email protected]

Rathfon Jeremy Research Engineer University of Louisville [email protected]

Ray Balmiki Post‐Doc Indiana University School of Medicine

[email protected]

Rempfer Debbie Executive Assistant Kentucky Science & Technology Corporation

[email protected]

Rickett Shannon Director of Commercialization

National Institute for Hometown Security

[email protected]

Ronald Ken Program Manager Kentucky Science & Technology Corporation

[email protected]


61

Rose Sheri Partner Commonwealth Leverage LLC

sheri.rose@c‐leverage.com

Sahai Atul NIDDK, National Institutes of Health

[email protected]

Schardein Greg Graduate Student University of Kentucky [email protected]

Schardl Christopher Professor University of Kentucky [email protected]

Schmidt Kyle Post‐Doc University of Louisville [email protected]

Schneider Keith Commercialization Director

ezone [email protected]

Sethi Manish Graduate Student University of Kentucky [email protected]

Sethu Palaniappan Assistant Professor University of Louisville [email protected]

Shapiro Robert Professor University of Kentucky [email protected]

Shelton Emily Shelton and Associates [email protected]

Shi Jing University of Kentucky [email protected]

Shultz Brad Limestone M&A [email protected]

Silas Mary Evans President Kentucky State University [email protected]

Singh Vijay P. Professor University of Kentucky [email protected]

Smith Kristel Director, Entrepreneur Services

Eastern Kentucky University

[email protected]

Stevens Randall ArchVision [email protected]

Stinton Shaun Post‐Doc University of Kentucky [email protected]

Streepey Ben Vice President & General Manager of Business Products

Lexmark International, Inc. [email protected]

Stump Richard VP Operations Transposagen Biopharmaceuticals, Inc.

[email protected]

Sunkara Mahendra Professor University of Louisville [email protected]

Talbott Debra Accounting Specialist Kentucky Science & Technology Corporation

[email protected]

Tang Guiliang Assistant Professor University of Kentucky [email protected]

Thompson Drew Post‐Doc University of Kentucky [email protected]

Timoney John University of Kentucky [email protected]

Tobin Thomas Professor University of Kentucky [email protected]

Tompkins Landon Engineer SCR Inc. [email protected]

Tran David Student Sullivan University College of Pharmacy

[email protected]

Trinkle Christine Assistant Professor University of Kentucky [email protected]

Turner Matt Research Engineer University of Louisville/Simon Sounds

[email protected]


62

van Gilse Margaret Vice President bioLOGIC [email protected]

Van Lanen Steven Assistant Professor University of Kentucky [email protected]

Venna Surendar Graduate Student University of Louisville [email protected]

Voor Michael Associate Professor University of Louisville [email protected]

Wan Rong Research Associate Senior


Warren Sean Engineer SCR Inc. [email protected]

Watson Lewis Graduate Student University of Louisville [email protected]

Webb Bruce Professor University of Kentucky [email protected]

Webster Nathan Post‐Doc University of Louisville [email protected]

Wehrle John Chief Financial Officer Kentucky Science & Technology Corporation

[email protected]

White Jennifer Assistant Professor University of Kentucky [email protected]

Wilhelm Michael Post‐Doc Kentucky State University [email protected]

Williams Jessica Commercialization Specialist


Willis Unique Post‐Doc Kentucky State University [email protected]

Womble Phil Professor Western Kentucky University

[email protected]

Wood Edward Student/Post‐Doc University of Kentucky College of Medicine

[email protected]

Wright Nicholas Research Assistant Western Kentucky University

[email protected]

Wu Lu Post‐Doc University of Kentucky [email protected]

Xie Bin President InfoBeyond Technolgy LLC [email protected]

Xue Liping Principal Scientist Advanced Dynamics, Inc. [email protected]

Yazdanpanah Mehdi CEO‐Founder NaugaNeedles [email protected]

Zanewicz James R. Director University of Louisville [email protected]

Zhang YuMing President Adaptive Intelligent Systems, LLC

[email protected]

Zhang Qunwei Assistant Professor University of Louisville [email protected]

Zhao Hongwu Senior Scientist Advanced Dynamics, Inc. [email protected]

Zhou Xuguo 'Joe' Assistant Professor University of Kentucky [email protected]

63

MENU

Continental Breakfast and Morning Break

Assorted Fruit Breads, Croissants, Muffins, Breakfast Pastries

Freshly Brewed Regular and Decaffeinated Coffee, Assortment of Hot Teas

All American Midwest Lunch Buffet

Mixed Field Greens with Roasted Corn, Cheddar Cheese, Sliced Black Olives, Croutons and Blue Cheese Dressing or Garlic and Herb Vinaigrette (Vegetarian)

Rice and Red Bean Salad with Smoked Cheese, Green Onions and Romano Cheese Vinaigrette (Vegetarian)

Grilled Sausage, Pasta and Roast Pepper Salad with Sweet Onions and Garlic Basil Emulsions

Mixed Citrus Segment Salad (Vegan)

Whole Roast New York Strips with Red Wine Demi‐Glace and English Cut Fried Onions

Parmesan‐Crusted Chicken Breast with Basil and Three Cheese Sauce

Eggplant Parmesan (Vegetarian)

Roasted Red‐Skin Potatoes and Assorted Fresh Vegetables Drizzled with Butter and Sprinkled with Parmesan Cheese (Vegetarian)

Assorted Pies and Cakes

Freshly Brewed Regular and Decaffeinated Coffee, Sweet Tea and Assortment of Hot Teas

Rolls and Butter

Afternoon Break

Freshly Popped Buttery Popcorn

Freshly Baked Assorted Cookies

Iced Tea, Sweet Tea, Lemonade

KIEC 2010 NOTES

65

KIEC 2010 NOTES

66

KIEC 2010 NOTES

67

KIEC 2010 NOTES

68

FLOOR PLAN

KIEC Poster Presentations

KIEC Display Tables

KIEC S iKIEC Sessions

8:45‐11:00 General Sessions: Salon A‐C11:00‐11:45 Poster Presentations: Odd Numbers11:45 12:30 Parallel Sessions: Salons A B and C11:45‐12:30 Parallel Sessions: Salons A‐B and C12:30‐2:15 Lunch/Networking: Bluegrass Pavilion2:30‐3:15 Poster Presentations: Even Numbers3:15‐4:15 Parallel Sessions: Salons A‐C, Darby

Dan and Calumet4:15‐5:15 Technology Session: Salon A‐B

KIEC Lunch

69

Registration

70

12

34

5/67/8

9/10

Display Table 1: A

dvanced Dynam

ics, Inc.Display Table 2: N

uForm M

aterials, LLCDisplay Table 3: SCR, Inc.

Dis play Table 4: Kentucky Energy and Environm

ent Cabinetp

y4

ygy

Display Table s 5‐10: Kentucky Com

mercialization Fund

2010 KIEC Program Book

Documents

Transcript of 2010 KIEC Program Book