n◊ YTf v11-~N IOEM r-Gtt11'.;;q n,u6c

TP.lt{) CHI ."\11:--tl ,_..;._..;,.,_ __ ,_, SC, q.1Z,. . ..... .

VII;: ~fEN NOOL6M THVOG TW TT LfyJ!IEN -DUQC T~~.~' N

&.1 h'ijo ~ TDHDTVN. V/v: tai ban Duqc dien Vi~t Nam VTfn 2

va dinh chinh DE)VNV lfrn 2.

C()NG HOA XA H()I CHU NGHiA VIE:T NAM D<)c l~p - Tl)' do - H~nh phuc

Ha N(Ji, ngay A.-t-thcing ~ nam 2020

Kinh gui: Cac cO' quan, dO'Il vi, doanh nghi~ p DtrQ'C Vi~t Nam

Trung tam Duqc diSn Vi?t Nam xin tran tr9ng thong bao dSn Quy co quan, don

vi v~ Duqc diSn Vi?t Nam V tai ban lful thu 2. Sau lful xmit ban d§.u tien vao thang 12

nam 201 7 va lful tai ban thu nh§.t vao thang 8 narn 2018, H9i d6ng Duqc diSn Vi~t

Nam da dua ra thong bao dinh chinh lfm thu nh§.t.

Tu d6 dSn nay, H9i d6ng Duqc diSn tiSp t\}c nh~ duqc g6p y phan h6i tu

nguai SU dl,lilg va trong qua trinh ra soat Duqc diSn, cac chuyen gia cua H9i d6ng

cung da phat hi~n them m9t s6 16i. H9i d6ng da ph6i hqp v6i Nha xu§.t ban Y h9c sua

chfra cac 16i va in DDVNV tai ban lftn thu 2.

Nhu v~y cac don vi, ca nhan sir d\Ulg ban in DDVNV tai ban 1§.n thu 2 se

Ir.hong c~n bfLtJ dinh chinh nua. Tuy nhien, DfJVNV in 1§.n aftu va 1§..'1 tai ban thu nh§.t

ck phai duqc sir d\Ulg kem theo Dinh chinh Duqc diSn Vi?t Nam V 1§.n 2.

Trung tam Duqc diSn - Duqc thu Vi~t Nam xin gui dSn nguai sir d\Ulg

DDVNV ban Dinh chinh Duqc diSn Vi~t nam V 1§.n 2 la t~p hqp cac n9i dung dinh

chinh lful d§.u va n9i dung dinh chinh m6i. D6ng thai, cac co quan, don vi, ca nhan c6

nhu d.u mua DDVNV tai ban 1§.n thu 2 c6 thS lien h~ voi can b9 ph\l trach phat hanh:

DS. Ph~m Binh Minh. 0T: 0936559950, 0243 8256905. Email: phamminh_sunny85

@yahoo.com; ho?c mua tnJc tiSp t~i Trung tam Duqc diSn - Duqc thu Vi~t Nam

t~i 48 Hai Ba Trung - Hoan KiSm - Ha N9i.

Xin tran tr9ng cam on.

N<Ji nh~n: - Nhutren, -Luu.

;o .. C

'" ~ TR

(~ D''O~ \~. V \,

'" -;',

Dinh chinh Dm;rc ditn Vi~t Nam V l§n 2

Trahe: _ ... Cot •o - - .Don2 Dain Sfra lai I ' .• :,.~ I "" - -

" , v 1$,(f Ban b6 sung DuQ'c di~n Vi~t Nam V Ban b6 sung DuQ'c di~n Vi~t Nam IV X',{\ ;:;.., ... ~ ~,,

·t~t xv ~1, ' _,,/fPit quan ky quan ly 16 " ~i:l:ll y0~9i Pha loang 1 ml dung dich thir (1) Pha loang 1 ml dung djch (1) 24 1 26! T?-p chat H: (2R)-2- T?-P chat H: Methyl (2R)-2-

30 2 2!, 6!, 10!, 2,86% 1,06% 19!, 23!

31 2 26,27! Dung dich chua 0,5 mg/ml acid 4- Dung djch chua 0,5 µg/ml acid 4-aminobenzoic (TT) va 2,0 mg/ml aminobenzoic (TT) va 2,0 ug:/ml

41 1 17, 18j

ch~ phAm can 20j 55 1 22! Pha loang dung djch (1) thanh 200 Ian Pha loang dung dich thu 200 Ian 75 1 Ii ceton keton 83 1 4j Ph\l l\lc 5.13 Ph1,1 l1,1c 6.4 144 2 li tinh theo che oham khan tinh theo che pham da lam kho 156 2 9 i Khong it hon 7 5 % Khong ft hon 75 % (Q) 157 1 l! dung dich thu (I) dung djch thir 162 2 13! ethanol ethanol 96 % 166 1 6i 0,5 ml 5,0 ml 251 l 21 phuang ohao B phuong phap 2 252 2 21j 20 mg/ml 20 ug/ml

12, 13 i 6 hai bu&c song eve d?,i 6 bu&c song CIJC d?,i 264 2 hi~u s6 d9 hip thv 6 2 bu&c song cµc hi~u s6 d9 h~p th1,1 6 hai bu&c song

9j d?-i Mcit chfr do in dung djch natri pentcuzs,ut+onat mr;nohycb-at

281 1 16, 17 ! 0,096 % (IT) da dUQ'C dieu chinh den pH 2,5 bing acid phosphoric (IT).

377 l 13j, !Si dung djch 0) dung djch thir (I) 378 2 20!, 22! dung djch (1) dung djch thir (1) 427 I 3! 1,0 g 0,25 g

430 1 9! Them 200 ml acetonitril (IT) va tr9n Them 300 ml acetonitril (IT) va tn)n d~u. d~u.

431 l 14 i Them 200 ml acetonitril (IT) va tr9n Them 300 ml acetonitril (IT) va tr9n d~u. d€u.

439 l 5! acid hydrocloric 10,3 % acid hydrocloric 1 M 467 2 22i Acid stearic: 90,0 % den 99,0 % Acid stearic: 80,0 % den 99,0 % 531 l 19 ! 45 h 45 min

555 1 3,4! va (0,5 phan tri~u hay 0,5 mg/ml) (0,5 ph!n tri~u hay 0,5 mg/I) 23,34! (st'.ra ca 6 4 o trong bang 1)

557 2 2i pie t?-p chat A pie lansoprazol 619 1 2! Mentho/um Levomentholum 631 1 31 d~y cMt ngay nap 19. d~y cMt ngay nap 19, can 19. 672 2 14j AlPO4.H2O AIPO4.xH2O 678 1. 25,26! dung dich (I) dung dich tht'.r 680 1 6! Dung djch nifedipin Dung dich nifedipin chuan 714 2 19! Phl1 lµc 9.1 Ph\l l\lc 9.2

1 16! da tam kho khan 716

2 8j, 13j, da lam kho khan 26j,32j 723 2 23i dung dich doi chieu (1) dung dich doi chieu 769 2 20! Phµlµc9.1 Phµ lµc 9.2 770 1 27j (1) (2) 781 1 16i Ph\l lt,ic 9.1 Phµ lµc 9.2 819 2 23 j Quinin bisulfat. Quinin hydroclorid.

820 ') 61 bisulfat". hydroclorid". --823/f ~~- ::.c::~ t bisulfat". hydroclorid".

83~s/ .,, 2 ,r -:.,,1\~t 100,0 % 110,0 % 8SiS::"( _ ~"l.~- ~., -9·j,,:24 i Phµ lµc 4.4 Phµ lµc 5.4 9t;t; 1,, ---· r - ...... __, ,r 2(3] 0,2 g natri sulfll 0, 1 g natri sulfit khan 93'4;,;.\ \I l 1i l . -1,~ ttt 4,6 cm 4,6mm

945~< -~ ~ 0A'4t Ph1,1 l1,1c 5.3 Ph1,1 l1,1c 5.4 .... ........_.- ~~

13t IM 0,5M 946 1

2j 3 binh dinh mt'.rc 3 binh dinh mt'.rc dung tich 50 ml

967 2 21 0,32 mm 0,53 mm

1078 2 21 2 cm den 5 cm 2 mm den 5 mm

1088 1 241 Ph1,1 h,ic 9.7 Ph1,1 l1,1c 9.8

1112 2 St Cortex Terminaliaen ni,zrovenulosae Cortex Terminaliae niwovenulosae

1136 1 251 dung djch sat (III) clorid (IT) dung djch sat (III) clorid 5 % (IT)

1139 2 51 Gymnemae sylvestris Gymnematis sylvestris

1144 I 41 mit ray 3,15 mm mit ray 0,355 mm

1151 1 61 30 ml 3 ml

1159 2 17,181 them 10 ml methanol (IT), dun hoi luu, them 100 ml methanol (IT), dun hoi luu 1 h,

1179 l 8j (7,5 : 2,5 : 4 gi9t) (7 ,5 : 2,5 : 0,2)

1182 2 191 (TT), xuat hi~n mau d6 tfa (IT), dun n6ng nh~, xuat hi~n mau d6 tfa

1184 1 24t HOANG BA (V6 than) HOANG BA (V 6 than, v6 canh)

1189 1 231,251 ethanol 96 % ethanol 70 %

1220 1 17, 18 1 duang kinh 2 cm d6n 0,5 cm duang kinh 0,2 cm d6n 0,5 cm

1221 1 lt dunf! djch acid hydrocloric IO % (IT) acid hydrocloric (IT)

1223 1 21i 8,5 % 11,0 %

1242 1 24 i Them 25 ml nuac Mo hoa n-butanol Them 25 ml n-butanol biio hoa nwc

Tren sac ky do, dung dich thfr phai c6 Tren sac ky do, dung dich thu phai c6 vet

1264 2 10, 11 i cac v~t (3 v~t) cimg mau sic va gia tri Rr cung mau sic va gia tri Rr v6i v6t cua v6i 3 v6t cua curcumin chuin curcumin chuin

Khong it hon 20,0 % tinh theo dm;rc li~u Khong du6i 20,0 % chat chiet duqc trong

kho ki~t. Ti6n hanh theo phuang phap nuac va khong du&i 1 0 % ch~t chi6t duqc

1301 2 6, 7, 81 chiSt n6ng (Ph1,1 l1,1c 12.10). Dung trong ethanol (IT) tinh theo duqc li~u kho ki~t. TiSn hanh theo phuang phap chiSt n6ng

ethanol (IT) lam dung moi. (Phu luc 12.10).

1322 2 12 i Herba Loranthi Graci'flolii Herba Loranthi paracitici

1382 2 l0j den 5 cm, den 35 cm,

Tro toan phin Tro toan phan (Phµ lµc 9.8)

1383 2 14,151 Khong qua 8,0% d6i v6i Thuy xuang b6 va Khong qua 4,6 % (Ph1,1 l1,1c 9.8). khong aua 10,0% d6i v&i Thi.ich xuang 1:>6.

1398 2 2j, 8j, 30j,

dung djch kali hydroxyd 0,5 N (CD) dung djch kali hydroxyd 0,5 N trong ethanol

32j, 38i, (CD)

P-33 Hinh du6i-

Ethambutol Fexofenadin g6c trai

PL-183 2 12j phuang phap 1 phuang phap 2

PL-225 2 23j Pha loang 1,0 ml Pha loang 10 ml thanh 100 ml bang nu&c. Pha loang 1,0 ml

PL-236 1 22t dioxin dioxan PL-248 2 . 22,23j dai khong qua 2,5 cm dai tu 2,5 cm tr& len

PL-258 I 14t pH4,8 pH5,8

PL-272 2 61 g 8

91 8 9 Phep thti nay khong ap d1,1ng duc;rc doi B6 cau nay

PL-300 1 9 i voi ch6 phftm thu6c c6 thanh phfrn chinh la vi sinh v~t s6ng