10 g/h
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10 g/h
glucagon
Glycémie 0,8 g/l
4 g/h
6g/hGLUCOSE
insuline
insuline
Homéostasie glucidiqueétat basal à jeun
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50 g/h
Glycémie 1,3 g/l
6g/hGLUCOSE
glucagon
insuline
44 g/h
insuline
Homéostasie glucidiqueaprès les répas
0 g/h
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GLUCOSE, INSULIN AND GLUCAGON PROFILES FOLLOWING MEALS
TIME (hours)Velho et al.,JCI 98:1755-1761, 1996
GLU
CO
SE
(m
M)
INS
ULI
N (
pM)
GLU
CA
GO
N (
ng/l)
151296304
5
6
7
8
9
10
11
151296300
100
200
300
400
500
600
700
15129630100
150
200
250
300
350
breakfast lunch dinner
n = 11 (m ± SEM)
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50 g/h
Glycémie 1,3 g/l
6g/hGLUCOSE
glucagon
insuline
44 g/h
insuline
Homéostasie glucidiqueaprès les répas
0 g/h
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Bell et al.: Nature, 2001
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Saltiel et al.: Nature, 2001
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Saltiel et al.: Nature, 2001
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10 g/h
glucagon
Glycémie 0,8 g/l
4 g/h
6g/hGLUCOSE
insuline
insuline
Homéostasie glucidiqueétat basal à jeun
![Page 9: 10 g/h](https://reader036.fdocument.pub/reader036/viewer/2022070400/5681352f550346895d9c9671/html5/thumbnails/9.jpg)
20 g/h
glucagon
Glycémie 1,6 g/l
4 g/h
6g/hGLUCOSE
insulineinsuline
Diabète de type 2 état basal à jeun
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50 g/h
Glycémie 1,3 g/l
6g/hGLUCOSE
glucagon
insuline
44 g/h
insuline
Homéostasie glucidiqueaprès les répas
0 g/h
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Diabète de type 2glycémie post-prandiale
50 g/h
Glycémie 2,4 g/l
6g/hGLUCOSE
glucagon
insuline
20 g/h
insuline
10 g/h
glycosurie
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GLUCOSE, INSULIN AND GLUCAGON PROFILES FOLLOWING MEALS
TIME (hours)Velho et al.,JCI 98:1755-1761, 1996
breakfast lunch dinner
n = 11 (m ± SEM)
MODY2 (n = 7)
controls (n = 11)(m ± SEM)