[06] Klasifikasi Morfologi Replikasi Virus (Nurul Wiqoyah, Dra.,MSi) 27-02-2013
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Transcript of [06] Klasifikasi Morfologi Replikasi Virus (Nurul Wiqoyah, Dra.,MSi) 27-02-2013
Nurul Wiqoyah
Klasifikasi dan identifikasi virus
Awal 1900an, virus dikelompokkan tersendiri Identifikasi:Karakteristik biologi, morfologi, struktur genom, sifat antigenik
Morfologi: ukuran, bentuk, capsid symmetry, ada tidaknya envelop
Sifat fisik virion,
struktur genom
lipid pattern, KH, protein struktural dan non struktural,\
sifat antigenik dan biologi , strategi replikasi , host range, mode of transmission dan patogenitas
Klasifikasi
Ordo ---- viralesFamili ---- viridaeSubfamili ---- virinae Genera ---- virusSpecies
Taxonomy Ordo MononegairalesOrder Family Subfamily Genus Type Species Hosta Mononegavirales Bornaviridae Bornavirus Borna disease virus V Rhabdoviridae Vesiculovirus Vesicular stomatitis Indiana virus V, I Lyssavirus Rabies virus V Ephemerovirus Bovine ephemeral fever virus V, I Novirhabdovirus Infectious hematopoietic necrosis virus V Cytorhabdovirus Lettuce necrotic yellows virus P, I Nucleorhabdovirus Potato yellow dwarf virus P, I Filoviridae Marburghvirus Lake Victoria marburgvirus V Ebolavirus Zaire ebolavirus V Paramyxoviridae Paramyxovirinae Rubulavirus Mumps virus V Avulavirus Newcastle disease virus V Respirovirus Sendai virus V Henipavirus Hendra virus V Morbillivirus Measles virus V Pneumovirinae Pneumovirus Human respiratory syncytial virus V Metapneumovirus Avian metapneumovirus V
V, vertebrate; I, insect; P, plant.
Fields Vriology (2007) 5th edition, Knipe, DM & Howley, PM, eds, Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia Table 2.2
Klasifikasi virus manusia"Group" Family Genome Genome size (kb) Capsid EnvelopedsDNA
Poxviridae dsDNA, linear 130 to 375 Ovoid YesHerpesviridae dsDNA, linear 125 to 240 Icosahedral YesAdenoviridae dsDNA, linear 26 to 45 Icosahedral NoPolyomaviridae dsDNA, circular 5 Icosahedral NoPapillomaviridae dsDNA, circular 7 to 8 Icosahedral No
ssDNAAnellovirus ssDNA circular 3 to 4 Isometric NoParvoviradae ssDNA, linear, (- or +/-) 5 Icosahedral No
RetroHepadnaviridae dsDNA (partial), circular 3 to 4 Icosahedral YesRetroviridae ssRNA (+), diploid 7 to 13 Spherical, rod or cone shaped Yes
dsRNAReoviridae dsRNA, segmented 19 to 32 Icosahedral No
ssRNA (-)Rhabdoviridae ssRNA (-) 11 to 15 Helical YesFiloviridae ssRNA (-) 19 Helical YesParamyxoviridae ssRNA (-) 10 to 15 Helical YesOrthomyxoviridae ssRNA (-), segmented 10 to 13.6 Helical YesBunyaviridae ssRNA (-, ambi), segmented 11 to 19 Helical YesArenaviridae ssRNA (-, ambi), segmented 11 Circular, nucleosomal YesDeltavirus ssRNA (-) circular 2 Spherical Yes
ssRNA (+)Picornaviridae ssRNA (+) 7 to 9 Icosahedral NoCalciviridae ssRNA (+) 7 to 8 Icosahedral NoHepevirus ssRNA (+) 7 Icosahedral NoAstroviridae ssRNA (+) 6 to 7 Isometric NoCoronaviridae ssRNA (+) 28 to 31 Helical YesFlaviviridae ssRNA (+) 10 to 12 Spherical YesTogaviridae ssRNA (+) 11 to 12 Icosahedral Yes
Fields Vriology (2007) 5th edition, Knipe, DM & Howley, PM, eds, Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia Table 2.1
Struktur dasar virus
DNA/ RNA + Capsid protein ---Nucleocapsid ---Naked virus
Nucleocapsid + lipid membran, glicoprotein --- enveloped virus
Brock Biology of Microorganism, 2012, M.T. Madigan et al
Icosahedral Cymmetry
Icosahedral
A, Human papilloma Virus (HPV), B. Tiga dimensi HPV
Helix
Helical Naked Capsid Virus
Bacteriophage
Virology, principle and Application, 2007, John Carter, V, Saunders
Replikasi virus4 fase dasar:
AttachmentEntry/ PenetrationGenome uncoatingGenome replication and protein synthesisAssembling progenyExit/ release
Attachment dan entry
Virology, principle and Application, 2007, John Carter, V, Saunders
Reseptor sel, protein virus dalam attachment
Virus Reseptor sel Protein yang terlibat dalam
Attachment ke reseptor
Fusi
Naked virus90% Rhinovirus mns
Poliovirus
Intercellular mol adhesion 1 (ICAM 1)CD155
VP1 +VP3
VP1
HIV-1 CD4 Gp120 Gp41
Virus influenzae A,B
Glycoprotein yang mengandung sialic acid
Haemagglutinin Haemagglutinin
Genome uncoating
Tergantung Virus, proses dapat terjadi:
1. pada permukaan sel, capsid tetap di permukaan sel 2. dalam sitoplasma3. dalam pori nukleus4. dalam nukleus
Assembly dan release
Virology, principle and Application, 2007, John Carter, V, Saunders