001 hematopoyesis
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DR. MARIO GUTIERREZ ROMERO
SERVICIO DE HEMATOLOGIAHOSPITAL GENERAL DE MEXICO, O.D. CLINICA LONDRES – ANGELES. México, D.F.
E mail: mgutierrezr_2000 @ yahoo.com.mx
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PERIODOS DE DESARROLLO:
1º MESOBLÁSTICO.- Fin de la 3er semana de gestación.
Islote eritroide (SACO VITELINO): Eritroblastos embrionarios (Hb F,
Hb Gower I y II, Hb Portland, estas 3 últimas desparecen al 2º mes ).
2º HEPATO-ESPLÉNICO ( BAZO Y G. LINFATICOS): 3º– 9º mes
Eritroblastos Eritrocitos (Hb A, Hb A2, HbF).
Megacarioblastos Megacariocitos Plaquetas.
Mieloblastos Granulocitos: Neutrófilos, Eosinófilos y Basófilos.
Monoblastos Monocitos. Células plasmáticas
Linfoblastos Linfocitos T y B .
3º MÉDULA ÓSEA: 5º mes y para toda la vida (Después del nacimiento
TODAS LAS CELULAS SE PRODUCEN UNICAMENTE EN MO).
HEMATOPOYESIS. ONTOGENIA
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HEMATOPOYESIS: ORIGEN
CÉLULA COMPROMETIDA MIELOIDE( UFC-E, Meg, G, M, E0, Ba ) FEC - GM
CÉLULA COMPROMETIDA LINFOIDE( UFC – LB, LT ) IL2
CÉLULA MADRE (STEM CELL) IL 3. CD 34.
MIELOIDE LINFOIDE
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UFBEPO
UFC-MEGTPO
UFC-Eo
IL5UFC-Ba
IL4
ERBL MEGCBL MLBL-Eo MLBL-Ba
Eritroc Plaq Eos Bas
FEC-G FEC-M
MLBL-N MNBL
Segm.Gr-Nt Mon
HEMATOPOYESIS: ORIGEN MIELOIDE
CÉLULA MADRE (STEM CELL) IL3
CÉLULA COMPROMETIDA MIELOIDE( UFC-E, Meg, G, M, Eo, Ba ) FEC - GM
UFC - GMMédulaósea
Sangre
*®
®
® También basófilos tisulares
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HEMATOPOYESIS: ORIGEN LINFOIDE
CÉLULA COMPROMETIDA LINFOIDE( UFC – LB, LT ) IL2
UFC – LBIL-6
UFC – LTIL-7
LFBL - B LFBL - T
Lnfc B Lnfc T
CÉLULA MADRE (STEM CELL) CD34+, IL-3
MMédulaósea
Sangre
C Plsm
UFC - NK IL-9
BL - NK
C - NK
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HEMATOPOYESIS. FUNCIÓN
TIPO: SOBREVIDA: FUNCIÓN:
GLÓBULOS ROJOS
PLAQUETAS
MONOCITOS
LINFOCITOS B. /CÉLULAS PLASMÁTICAS
LINFOCITOS T(CD 4 COOPERADORES,
CD 8 CITOTÓXICOS)
120 días.
11 días.
7 horas.
?
?
?
Acarreo de O2 y de CO2
Hemostasia trombo blanco.
Fagocitosis/Inflamación. Puente con algunos procesos inmunes.
Células procesadoras de Ag (CPA). Fagocitosis.
Inmunidad humoral (Ac)
y memoria inmunológica.
Inmunidad celular o de
hipersensibilidad retardada.
GRANULOCITOS: NEUTROFILOS,EOSINOFILOS Y BASOFILOS.
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