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Transcript of 목차 - kbri.re.kr…„도 뇌연구촉진... · Ⅰ. 계획수립의 배경 ∙ ∙ ∙ 추진...

  • contents

    . 1 3 4 2 2 5 2 2 8

    . 2014 11 13 15

    . 17 19 24

    . 2015 27 15 29 30 32 33 41 43

    44

    2014 44 61

    : 2015 63

  • .

    2 2 2 2

  • . 3

    I

    1

    2 2(1317)

    :

    , ( 5)

    ( 6)

    : , , , (14)

    99.7 : 1 (9807)

    07.12 : 2 (0817)

    - 2017 7

    13.6 : 2 (2, 1317) (13)

    14.4 : 2014 (14)

    2 2('13'17)

    2015

  • 4 2015

    ( 14)

    , R&D ,

    2

  • . 5

    2

    3 2 2

  • 6 2015

    2

    2

    1 R&D , , 3

    2 2

    3 2

  • . 7

    2

    - (1317) 6,245()

    '07 (1 5,000: '08'17) 61.9% ( )

    ( : ) * IBS** *** 2013 561 200 103 8642014 589 200 360 1,1492015 619 200 443 1,2622016 650 200 561 1,4112017 682 200 677 1,559 3,101 1,000 2,144 6,245

  • 8 2015 * '13 561 ('12'16) (5%)

    ** 2 IBS (13 50% )

    *** ()( : ('12, ())

    - (17 9,300)

    , ,

    < >( : )

    12 13 14 15 16 17

    2,844 3,603 4,565 5,784 7,329 9,286

    *

    * 17 1 (15%)

    - 12 22.0% 17 30%

    4 2 2

  • . 9

    ()

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    .

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    3. : ()

    ( 25751, 14.11.19)

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    2

    .

  • . 2014

  • . 2014 13

    II 2014

    1

    1,045('14 -2.6% )

    '14 : 1,073

    (SCI DB )- IF20 IF10 1%10%

    129

    - 59.9% 14 17.9%

    ( 156, 90)

    - 45('14 13.5%), 10('14 37.5%)

    2,426

    () 310 - 113, 197

    66- 51,

    - 15

    24

    6,591 (, )

    () 2014

  • 14 2015

    () 14 : 105,354

    - 75.2% (79,237)

    () 47.4% (49,982)

    - 13.9% (14,643)

    - 6.0% (6,301)

    - 4.9% (5,173)

    < 2014 >( : )

    ()

    15,586(5,096)

    30,661(24,406)

    23,979(17,725)

    9,011(2,756)

    79,237(49,982)

    - - 14,643 - 14,643

    1,514 1,290 1,761 1,738 6,301

    - - - 5173 5,173

    17,100 31,950 40,383 15,921 105,354

    - 38.3% (40,383)

    - 30.3% (31,950)

    - 16.2% (17,100)

    - 15.2% (15,921)

  • . 2014 15

    1)

    IF20 IF10 1%10% 129

    - 106( 56), 14, 9

    - IF20 7, IF10 38

    , 2 93%(120)

    156, 94 59.9%

    45, 10 22.2%

    : 2,426

    : 113, 197

    : 66

    - 51, 15

    : 24

    2)

    , ,

    6,591

    2

  • 16 2015 < 2014 >

    () ()()

    ()

    IF20IF10 JCR

    ()

    1%5%10%

    62 27 12 53 14 6118

    /86911

    - - - 50 88 7622 10 21

    10 6 3 2- 6 230/

    417 - - - 23 41 1193- 1 7

    49 35 13 11 5 304/

    304 1 2 40 14 57 138- 1 2

    16 9 - 0- -

    - 4 4 42 - - 124- - -

    KIST 8 5 5 21 6

    34/54 - - - 19 9 1124 8

    - - - -

    - 19/16 - - - - - 35

    5 3 -

    2 3 1 -- - -

    7/9 - - - - 1 10- - -

    8 9 11 -- - -

    11/22 - - - - - 17- - -

    - - - -

    - -- - - - - - -

    - - -

    IBS 2 - - -2 6

    11/16 - - - 7 1 355 15

    157 94 45 107 38 6724/

    87749 5 6 82 113 197 2,4267 24 53

    / /

  • .

  • . 19

    III

    1

    1990 10(Decade of the Brain) , 1

    - 2013 Brain Initiative"

    ( )

    20042005 : ,

    20062008 : , ,

    20092010 : NIH Blueprint for Neuroscience

    (Grand challenge)

    Blueprint Grand Challenge (09), (10)

    2013. 2 :

    'Brain Initiative

    Brain Initiative 10 30 ( 32)

    ( )

    (NIH) 16

    Blueprint for neuroscience

    research*

    *

  • 20 2015 ( )

    , ,

    - (09) :

    , , , UCLA

    - (20092010) :

    - (2010) :

    - (20102011) :

    - Brain Initiative (2013) :

    (National Alzheimer Project Act

    Law) (11.1.4 )

    2025. 12. 31 .

    , , ,

    ( )

    14 NIH 311 ,

    50

    (8), (4)

    - '13 "Brain Initiative(Brain Activity Map)"

    10 30( 3 2)

    2014(4)

    EU

    (FET )

    (Human Brain Project, HBP)

  • . 21 -

    (Research council)

    , (Welcome Trust)

    - Welcome Trust-MRC

    3 ( 6) ('08.10)

    , ,

    MRC Neuroscience and

    Mental Health Board(NMHB)

    (iPS)

    - CNRS() INSERM(

    )

    400

    7 (FP7) NAD(Nanoparticles for the therapy and diagnosis of Alzheimer's disease)

    - MPI()

  • 22 2015

    MPI, PET-MRI

    Computational Neuroscience Bernstain

    Award (06)

    EPFL Blue Brain Project

    (BBP) , HBP

    21

    (1997~2016)

    - 98 ` (Brain Science Institute)'

    (RIKEN) , , ,

    ,

    : (OIST), (NIPS) : RIKEN BSI, RIKEN

    2009

    300

    2004 NT, IT

    2014 Brain/MINDS 1 30, 2 40

  • . 23

    - 9 2 ( ,)

    - 13 10

    Shanghai Institutes of Biological Sciences(SIBS)

    (ION) * *

    < >

    Decade of Brain (90)- NIH (National AlzheimerProject Act: NAPA)'(11)

    Brain Initiative(13)-

    (0711)

    - 7 council Ageing brain"-

    (ips)

    (96) (97)

    (07) (08)

    Brain/MINDS (14)

    (98) 2 2 (1317)

    (08) (15)

    50(14)( 16%)

    17,580(13)( 20.8%)

    3(10)/(BT 7%) Brain/MINDS(1 30,

    2 40)

    1,045(14)(BT 4.5%)

    NIH 16

    Brain Research UK(11)-

    RIKEN BSI(98 )

    KIST (11)IBS (3)(1213)

    NIH MRC

  • 24 2015

    1

    2014 1,045 2 3 4.5% : (16%), (7%),

    (20.8%)

    98

    ('10 630) : 1.26%*, 21%**

    * NIH() 50 (1,060/), ** 300(10/)

    2012 2(1317) 2

    -

    2

  • . 25 () BT R&D 5

    (13)

    - BT *

    * , , ,

    -

    (World Class Institute: WCI)

    KIST (0914)

    * 70/

    KIST (11) (IBS)

    (12)

    ,

  • 26 2015 < (0714) >

    (: )

    /

    200713,399

    (32.6%)

    5,506

    (13.4%)

    15,605

    (38.0%)

    3,924

    (9.5%)

    2,690

    (6.5%)

    41,124

    (100%)

    200812,563

    (26.4%)

    7,411

    (15.0%)

    13,066

    (25.5%)

    8,353

    (17.0%)

    7,935

    (16.1%)

    49,268

    (100%)

    200911,031

    (19.7%)

    8,961

    (16.0%)

    21,563

    (38.5%)

    8,325

    (14.9%)

    6,078

    (10.9%)

    55,958

    (100%)

    20109,602

    (15.2%)

    8,522

    (13.5%)

    30,644

    (48.7%)

    6,925

    (11.0%)

    7,282

    (11.6%)

    62,975

    (100%)

    201112,093

    (17.7%)

    7,505

    (11%)

    33,669

    (49.2%)

    9,275

    (13.5%)

    5,920

    (8.6%)

    68,462

    (100%)

    201210,733

    (16%)

    7,403

    (11%)

    33,066

    (49%)

    7,039

    (11%)

    7,550

    (11%)

    66,841

    (100%)

    201316,223

    (18.6%)

    20,193

    (23.1%)

    42,606

    (48.8%)

    8,368

    (9.6%)

    87,390

    (100%)

    201417,100

    (16.2%)

    31,950

    (30.3%)

    40,383

    (38.3%)

    15,922

    (15.1%)

    105,354

    (100%)

    :

  • . 2015

    15

  • . 2015 29

    2015

    1 15

    3 15

    1,267

    987

    ( 596)

    67

    141

    72

    < / 2015 >

    ( : )

    1

    R&D

    2

    3

    ()

    55,784(28,780)

    15,271(15,271)

    27,617(15,581)

    98,672(59,632)

    6,668 6,668

    14,111 14,111

    7,199 7,199

    76,563 15,271 34,816 126,650

  • 30 2015

    2

    1) 15

    () (14) 105,354 (15) 126,650(20.2% )

    () 77.9%(98,672)* ,

    11.1%(14,111), 5.7%(7,199),

    5.3%(6,668)

    * () : 47.1%(59,632)

    4.5%,

    (10.3%), (4.1%), (3.1%),

    (1.7%)

    39.2%(2,026), 24.5%(19,435),

    5.8%(367), -3.6%(-532)

    < 2015 >( : , %)

    15 14

    (%)

    ()

    22,782(10,595)

    33,526(24,575)

    30,087(21,136)

    12,278(3,327)

    98,672(59,632)

    79,237(49,982)

    24.5(19.3)

    1,580.5 1,580.5 1,926.5 1,580.5 6,668 6,301 5.8

    7,199 7,199 5,173 39.2

    14,111 14,111 14,643 -3.6

    24,362 35,106 46,125 21,058 126,650 105,354 20.2

  • . 2015 31 2)

    2015

    36.4% 46,125

    (36.4%), (27.8%),

    (19.2%), (16.6)

    42.5% (7,262),

    32.3% (5,136)

  • 32 2015

    3

    *

    -

    , ,

    ,

    - () , ---

    ()

    * ,

    IBS , KIST

    2

    2

    () (34 )

    *

    - ()

    ) (10)

  • . 2015 33

    (14 77,037 15 96,172, 24.5% )

    2015

    4 (, , , )

    8

    2 2 (1317) 4 (, , , )

    8 ()

    (/15/3,620)()

    (/1519(5)/22,700 )(-4 ) (7T MRI)

    (/1418(5)/5,000 )(-)

    (/1418(5)/30,000 )()

    (15/4,700)

    (13,968), (1,000)

    () (15/20,271)

    3 IBS (15/25,701)()

    4

  • 34 2015 (14 6,301 15 6,668, 5.8% )

    2015

    14,000

    BK21 : 250

    (14 5,173 15 7,199, 39.2% )

    2015

    - - /

    - PC Mobile Device

    Agent App

    - / -

    - 1 3D

    -

  • . 2015 35 (14 14,643 15 14,111, 3.6% )

    2015

    - (, )

    - ,M.D.-Ph.D.

    - , Imaging Surrogate Marker

    - ,

    - , , , , 5

    - , , - ,

  • 36 2015 (14 5,146 15 8,578, 66.7% )

    2015

    /

    - - -

    / - -

    - -

    - (FLIPR) - (S1P1/5) - S1P1/5 - (Nrf2) - (EAE) in vivo

    - - miRNA -

    - (mGRASP)

    -

  • . 2015 37 -

    : - , , 3D ,

    (14 14,559 15 20,271, 39.2% )

    2015

    Brain Damage

    Brain Damage - - , ,

    ,

    - () Serial Face Block SEMTIRFM 7

    - () () /

    - () , (/ ) ( )

  • 38 2015 (14 3,245 15 2,500, 23.0% )

    2015

    miRNA

    ()

    miRNA - Alzheimer disease - miRNA

    (14 0 15 1,500)

    2015

    ,

  • . 2015 39 (14 1,098 15 1,081, 1.5% )

    2015

    - NMR/MRI

    - / /

    -

    (14 25,934 15 25,702, 0.9% )

    2015

    ,

    (Synaptic adhesion molecule)

    (Synaptic signaling scaffold)

    (knock-in mice)

    simple system deliberate system

    CA3

    -

  • 40 2015

    MRI/fMRI

    LED

  • . 2015 41

    () BT&ICT

    8

    , ,

    ,

    ()

    14 : 3,500; 14 : 2,426

    67%

    ()

    14, IF20 IF10 1%10% 129,

    JCR 2,100( 6% )

    ()

    14 306, 11

    151 (48%), (29%), (12%), (11%)

    ()

    11 3,000/14 3,500 11.6% (

    )

    310, () 43( 83%,

    14%, 3%) 13.9%

    5

  • 42 2015

    ()

    () (

    )

    ()

    (75%) (46%)

    ()

    ()

  • . 2015 43

    6

    2015

    2015

    2015

    2016

    2016

  • 44 2015 1 2014

    IBS

    /

    1.

    .

    .

    2.

    .

    3.

    .

    -

    .

    -

    .

    - Proc. Natl. Acad. Sci. USA (2014)

    .

  • . 2015 45

    IBS

    /

    1. (Trk)

    ,

    .

    2.

    ,

    .

    3.

    ,

    .

    - ,

    .

    - .

    - Nature Communications (2014)

    - Molecular & Cellular Oncology (2014)

    ,

    .

  • 46 2015

    IBS /

    1.

    .

    2.

    ( )

    .

    3.

    ,

    .

    - ,

    .

    - .

    - Nature Methods (2014)

    - Trends in Biotechnology (2014)- Nature Reviews Molecular Cell Biology (2014)

    .

    .

    ,

  • . 2015 47

    NGL-3 /

    (synaptic protease)

    , NGL-3

    (synaptic adhesion molecule) ,

    (, long-term depression LTD)

    .

    LTD(chemical LTD) .

    (LTD)

    .

    Phil. Trans. R. Soc. B. (2014)

    NGL-3

    NGL-3 /

  • 48 2015

    (crack) /

    1. (Lyriform slit organ)

    (crack)

    2. (crack)

    ,

    ,

    lab on a chip

    3.

    1,000 (2% )

    ,

    (crack)

    lab on a chip

  • . 2015 49

    Glucose Transport & metabolism MRI /

    1.

    2.

    glucose transport metabolism

    3. MRI

    protein, peptide, neurotransmitter

    PET (Positron Emission Tomography) glucose

    MR spectroscopy 100

    biomarker

  • 50 2015

    /

    /

    1. , , ,

    ,

    2.

    ,

    3. REV-ERB (NR1D1)

    , /

    ,

    (mania)

    4. REV-ERB

    First-in-Class

    -

    ,

    -

    - : Chung et al., 2014, Cell 157:858

    - :

    2 ( 10-2014-0055117

    10-2014-0055121)

    REV-ERB

    . /

    / 30~60%

    ,

    /

  • . 2015 51

    3

    /

    1.

    , CA3 CA1

    .

    2.

    (mGRASP) 3

    CA3 CA1 3

    3.

    1:1 CA3, CA1

    .

    4.

    ,

    (WCI)

    -

    1:1

    - ,

    ,

    - : Neuron (2014)

    Nature Protocols (2014)

    (mGRASP) 20nm

    .

    3 3

    ,

    3

    3D Data Base , , ,

  • 52 2015

    /

    1.

    ,

    2.

    -B

    3. -B

    ,

    (WCI)

    Flagship

    - -B

    ,

    .

    - -B

    ,

    - : Nature Medicine (2014)

    - :

    (: 10-1438532, : 5589037)

    -B , ,

    .

    .

    ,

    ,

    MAO-B, Best 1

    -B

  • . 2015 53

    /

    1.

    ,

    2.

    3.

    4. (TWIK-1)

    (TREK-1)

    ,

    (WCI)

    -

    , ,

    -

    - : Nature Communications (2014)

    ,

    .

    -

    , ,

    ,

  • 54 2015

    NASA/

    1.

    2. 100 nanomole

    3.

    ,

    4.

    5.

    ,

    4: U.S. Patent No: 8,909,491 (2014),

    PCT/KR2008/002663 (2010), PCT/KR2008/002662

    (2010), PCT/KR2008/002662 (2010)

    2: 10-1351779 (2014), 10-1351794

    (2014)

    NASA Langley Research Center

    NASA

    1mm3

    image sensor

    1/100

  • . 2015 55

    (, , , )

    , ,

    Medtronics

    Localized Field Potential

    . ,

    ,

    ,

    ,

    ,

    , , , , .

    , polymer film quality check, ,

    ,

    ,

    2015

  • 56 2015

    GluA2- AMPA

    /

    1. ,

    3

    2. -

    GluA2- AMPA

    3. GluA2- AMPA 15

    76%

    4. , (14 8, 9), PLoS One

    (14 8)

    - ,

    .

    - . GluA2-

    AMPA

    - Nat Neurosci (2013)

    - PLoS One (2014)

    GluA2- AMPA

    GluA2- AMPA

    .

    ( , , )

    /

    /

  • . 2015 57

    S100A9

    /

    - S100A9

    ,

    - S100A9

    -

    microglia tumor necrosis

    factor(TNF)-, Interleukins (IL-6, IL-10)

    - ,

    Tg2576 x S100a9K/O in vivo

    ,

    - PLOS ONE (2014)

    S100A9 ,

  • 58 2015

    /

    .

    (

    )

    /World Class Laboratory(WCL)

    -

    - NeuroImage (2014)

    - 2014 YTN, , MBC, , 30

    - / //

    ( 7, 10)

    - BIOMAG2016

    - SQUID NMR

    - -

    - 10

    K-step , /

    , ,

    ,

    ( )

  • . 2015 59

    G lucocerebrosidase depletion enhances cell-to-cell

    transm ission of -synuclein /

    1. (PD) -synuclein

    ,

    2. Glucocerebrosidase

    -synuclein

    3. Glucocerebrosidase

    -synuclein

    (PD) -synuclein

    Glucocerebrosidase

    -synuclein

    -synuclein

  • 60 2015

    Direct cellular delivery of human proteasomes

    to delay tau aggregation /

    1.

    ()

    2.

    ()

    (SiO)

    3.

    -

    -

  • . 2015 61

    2

    14 15

    2,000 1,000

    - 02.9 2,000 1,000

    14,060 24,072

    - 06.11 14,060 24,072

    13,195 13,968

    - 00 3,771 3,360

    - 86 7,188 8,372

    - 97 2,236 2,236

    1317

    5,146 8,578

    - 5,146 8,578

    09.6

    14,559 20,271

    - 14,559 20,271

    3,245 2,500

    - 12.114.12 755 300

    - 12.114.12 290 -

    - 14.117.12 2,200 2,200

    13.115.12

    1,098 1,081

    - 1,098 1,081

    15.119.12

    - 1,500

    - - 1,500

    (IBS) 25,934 25,702

    - 12.716.12 7,934 7,902

    - 12.816.12 6,000 5,800

    - 13.717.12 12,000 12,000

    79,237 98,672

    [] [49,982] [59,632]

    89

    3,979 4,346

    - 3,979 4,346

    BK21 13.920.8

    2,322 2,322- BK21 2,322 2,322

    6,301 6,668

    13.616.7

    - 3674 5326(1499) (1873)

    5,173 7,199

    (R&D)13

    - ()14,032 13,500(611) (611)

    14,643 14,111

    ()105,354 126,650(2,110) (2,484)

  • 2015

  • 65 1.

    []

    (, MRC)

    1.

    :

    10 , 7(4+3)

    - -

    6()

    ( )

    - 22

    2002 9

    - 15 2015.3.1.2016.2.28 / 2015.9.12016.8.31

    214,551(, 14 )

    - 15 33,100() / ( 1,000)

    2. 2014 ()

    1) (, , , )

    NeuroimageIdentifying neuropathic pain using 18F-FDG micro-PET: A multivariate pattern analysis

    2014.02.01.

    Cell death & Differentiation

    Crucial role of calbindin-D28k in the pathogenesis of Alzheimers disease mouse model

    2014.05.23.

  • 66 2015

    1

    2 3

    ()

    2014 ()

    8 9 400 9 19 3

    2)

    ( )

    IF 20

    IF 10

    1%

    5%

    10%

    JCR

    (/

    )

    2 1 35

    Nucleic Acids Research

    ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription

    2014.02.01.

  • 67

    ()

    ()

    ()

    4 3

    () ()

    () () (3)

    2 1 69

    ()

    ()

    () ()

    8

    3. 2014

    4.

    ()

    -

  • 68 2015 5. 2015

    (MRC)33,100, 31, 3

    ( )

    - 1(1,000)

    6.

    7.

    / 14 /15/

    3 /

    - 50% 70% 100%

    50% 70% 100%

    8. ()

    2012

    2103

    2014

    2015

    2016

    (MRC)

    02

    154,851 29,750(2,000)29,950(2,000)

    33,100(1,000) 34,000 281,651

    154,851 29,750(2,000)29,950(2,000)

    33,100(1,000) 34,000 281,651

    154,851 29,750(2,000)29,950(2,000)

    33,100(1,000) 34,000 281,651

    154,851 29,750(2,000)29,950(2,000)

    33,100(1,000) 34,000 281,651

  • 69 9.

    Brand

  • 70 2015 []

    , ,,

    1.

    O O

    /

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  • 72 2015 - GluR2- AMPA (/

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    biomarker

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  • 75

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  • 82 2015 - 4 (, ) 2

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  • 84 2015

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  • 86 2015

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    10% 30% 70%

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  • 87

    9. ()

    2012

    2103

    2014

    2015

    2016

    06~

    32,940 9,110 14,060 24,072 60,144 140,326

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  • 88 2015 10.

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  • 89 []

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  • 90 2015 : (, )

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    201511120161031, 201512120161130

    - '15 142,500( 3,360)

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    Impact of Circadian Nuclear Receptor REV-ERB alpha on Midbrain

    Dopamine Production and Mood Regulation(Cell, 2014.5)

    20

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  • 91

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  • 92 2015 8.

    9. ()

    2012

    2103

    2014

    2015

    2016

    ()1999~

    135,349(3,674)146,100(4,283)

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  • 94 2015 14 30,198

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    1) (, , , )

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    alpha-synuclein(Nature Communications)

    - Extracellular alpha-synuclein-a novel and crucial factor in Lewy

    body diseases(NATURE REVIEWS NEUROLOGY)

    * 2014 50 ( )

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    47

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    314,677 348,795 388,295

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    * 2014 30,198 / 2016

  • 97 10.

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  • 98 2015

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    Biol SciShank mutant mice as an animal model of

    autism 2014.01

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    Biol Sci

    NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that

    are induced by different patterns of stimulation

    2014.01

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    NeuronCoexistence of two forms of LTP in ACC provides a synaptic mechanism for the

    interactions between anxiety and chronic pain2014.12

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  • 103 2) 15

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  • 105

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  • 106 2015 2.

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  • 108 2015

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  • 109 7.

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    2014

    2015

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    89

    291,651(5,125)

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    '15 2,285 96 316

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  • 111 2013. 9 2020. 8

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    Chemical Communications

    ( , 2013.11)

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    Cell ( , 2014.5.8)

    - 9

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    - The 6th International Conference on Brain and Cognitive Engineering

    ('14.6.276.29, )

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  • 112 2015

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  • 113 8.

    ()

    2012

    2103

    2014

    2015

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    BK21

    13.920.8

    138,700(1,394)272,913(2,322)

    273,000(2,322)

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  • 114 2015 3.

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  • 115 16,676( 12,000, 4,676)

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    Meditation (Frontiers in Integrative Neuroscience, '14.01)

    - Heart Brain Synchronicity As An Integrated Heart Brain Anti-aging

    Marke (The 21th International Stress and Behavior Society, '14.02)3.

    - Rate of energy consumption during ADL in Korean life style

    setting (ISBNPA '14.5)

    - An Empirical Analysis on the Performance Factors of Software

    Firm (IJSEIA, '14.12)

    - ()

    (: 10-2014-0037957, '14.03)

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  • 116 2015 - () LVDS Linux SW

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  • 117 4. 2014

    2 (15.10)

    5.

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  • 118 2015 9.

    ()

    2012

    2103

    2014

    2015

    2016

    (

    )

    2013.6 ~2016.10

    3,000 3,674 5,326 12,000

    1,304.2 1,498.641 1,873 4,676

    4,304 5,173 7,199 16,676

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    2. 2014

    1)

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    * Glucocerebrosidase depletion enhances cell-to-cell transmission of

    -synuclein 2014 Nature Communications(IF: 10.74)

    - ()

    * Direct cellular delivery of human proteasomes to delay tau

    aggregation 2014 Nature Communications(IF: 10.74)

    - ADHD(Attention-Deficit/Hyperactivity Disorder)

    * Connectomic disturbances in attention-deficit/hyperactivity disorder:a whole-brain tractography analysis 2014 Biological Psychiatry(IF: 9.47)

    - ( 23 , 2,692 )

  • 120 2015 () 19 , 80 , 3 () 4 , 300 , 3 - ( 5 , 2,295 ) () 500 , 5(3+2) - ( 8 , 1,470 ) (Level 1) 6, 100, 2 (Level 2 ) 2 , 500 , 5 () - ( 19, 16, MOU 3) ( 6, , ) - ( 8) () 1, K-ADNI() ( ) 7, - ( 4) K-ADNI(), ('14.09.25, )

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    6 1 7 230 34

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  • 121

    ()* ()

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    * , 2014

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    3. 2014

    4. 2015

    4,900

    - 2,800( 6, 29)

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    - 3,100()

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  • 122 2015 - 2,000()

    , , , , 5

    : 2,000( 16, 4)

    , , ,

    5. ()

    2012

    20132014

    2015

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    *

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    95,524 95,524

    7,840 7,840

    103,364 103,364

    *

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    13,833 14,032 13,500 13,500 54,053 1,570 611 611 611 3,403 15,403 14,643 14,111 14,111 58,268

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  • 124 2015 3. 2014 ()

    1) (, , , )

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    - Opto-EEG

    - UST 2, 1

    ()

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  • 125 4. 2014

    disease

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    / ,

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    5.

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    6. 2015

    1) '15 /

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  • 126 2015 - /

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    5)

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    8.

    / 14 / 15/ 3 /

    OFC mPFC PLC1-KD

    OFC mPFC PLC1-KD

  • 127

    9. ()

    2012

    2103

    2014

    2015

    2016

    /

    2013.12015.12

    2,074 2,074 2,074 6,222

    2,074 2,074 2,074 6,222

    2,074 2,074 2,074 6,222

    2,074 2,074 2,074 6,222

    / 14 / 15/ 3 /

    1.

    2.

    -

    -

    -

    -

  • 128 2015 10.

    - /

    - ,

    -

    -

    -

    - ,

    ,

  • 129

    1.

    /

    2.

    (ventral hippocampus, VH)

    - , , ,

    -

    -

    2013 1 2015 12

    - '15 2015 1 2015 12

    572 (, )

    - '15 504(, )

  • 130 2015 3. 2014 ()

    1) (, , , )

    -

    Cell Neuron (IF 15.982)

    - Cell

    Neuron (IF 15.982)

    -

    Nature Protocols (IF 7.78)

    ()

    - ( , RIKEN, IINS,

    ) 8 CFC 3

    - Janelia Farm Research Campus, HHMI

    Neuron (IF 15.982)

    - New York University Neuron (IF 15.982)

    2)

    ( )

    IF 20

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    5%

    10%

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    )

    0 2 0 2 2 4/6 0

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    ()

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    () (3)

    12

    ()

    ()

    ()

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    . ,

    5.

    ()

  • 132 2015 6. 2015

    1) '15 /

    -

    -

    ,

    -

    -

    - ,

    2) '15

    3)

    4)

    () ETRI, KAERI,

    , , KAIST, ,

    7.

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    2

    ,

    2) /

    ,

    3) (16 )

  • 133 ,

    4) ()

    Jinny/Axio Slide Scanner(169, 2014)

    NeuroCCD (138, 2013)

    5)

    8.

    / 14 / 15/ 3 /

    10% 30% 70%

    9. ()

    2012

    2103

    2014

    2015

    2016

    2013.12015.12

    786 572 504 1,862

    786 572 504 1,862

    786 572 504 1,862

    786 572 504 1,862

    10.

  • 134 2015

    1.

    /

    2.

    - S1P1/5

    - Nrf2

    - ,

    2014 1 2018 12

    - '15 2015 1 2015 12

    5,850 ()

    - '15 1,170()

    3. 2014 ()

    1) (, , , )

  • 135

    - J. Med. Chem, British J. Pharmacology, Eur. J. Med. Chem.,

    Org. Biomol. Chem., PlosOne SCI 12

    ( )

    - : G

    - 2014.09.01-2018.03.31

    - 15, : 9( )

    -

    - 2014.12.01-2019.10.31

    - 23, : 115

    - 4, 4

    - PCT 2, 1

    - 1, 6

    ()

    -

    ( , 5/)

    2)

    ( )

    IF 20

    IF 10

    1%

    5%

    10%

    JCR

    (/

    )

    0 0 0 0 2 12/12 2

  • 136 2015

    ()

    ()

    ()

    4 4 3

    ()

    ()()

    ()

    (3)

    1 6 6 30

    ()

    ()

    ()

    ()

    1

    4. 2014

    Multiple Sclerosis SIPR Nrf2

    target .

    , . SIP1 SIP5

    .

    1, ( - )

    .

    FTY720 KIST PAK1 kinase

    ( ) .

  • 137 1

    Nrf

    .

    5.

    ()

    S1P1/5

    Nrf2

    6. 2015

    1)

    - FLIPR

    - S1P1/5

    - S1P1/5

    - Nrf2

    - EAE in vivo

    2)

    - 5

    - 5

    3)

    -

    -

  • 138 2015 7.

    1)

    S1P1/5 Nrf2

    in vitro/in vivo

    ADME/Tox, PK

    2) /

    3) (16 )

    4) ()

    Live-cell FRET imaging microscope(1 5,

    FRET )

    Fluorescence-activated cell sorting(FACS)(4, )

  • 139 5)

    5/ 2

    5

    8.

    / 14 / 15/ 3 /

    30% 50% 70%

    9. ()

    2012

    2103

    2014

    2015

    2016

    2014.12018.12

    1,200 1,200 3,600 6,000

    1,200 1,200 3,600 6,000

    1,200 1,200 3,600 6,000

    1,200 1,200 3,600 6,000

    10.

    , ,

  • 140 2015

    1.

    O

    /

    2.

    (Extracellularvesicle)

    -

    - RNA

    -

    -

    - miRNA

    -

    2013 1 2015 12

    - '14 2014 1 2014 12

    3,900 (, )- '14 1,300 (, )

  • 141 3. 2014 ()

    1) (, , , )

    No SCI

    1 SCI

    Partially flexible MEMS neural probe composed of polyimide and sucrose gel for reducing brain damage during and

    after implantation

    Journal of micromechanics

    and microengineering

    2014.02

    2 SCI A multi-channel oscillator for a resonant chemical sensor system

    IEEE transactions on industrial electronics

    2014.10

    3 SCI

    Piezoelectric layer embedded-microdiaphragm sensors for

    the determination of blood viscosity and density

    Applied physics letters 2014.10

    4 SCI Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers Lab on a chip 2014.03

    5 SCIPressure-driven fast reaction and

    recovery of peptide for an electronic nose application

    Applied physics letters 2014.02

    No /

    1 2013.11.25

    2 2014.01.243 2014.07.234 2014.10.07

    5 2014.06.24

    6 PCT 2014.10.28

    7 2014.09.02

    8 2014.09.16

  • 142 2015 - 2()

    () - ()

    2)

    ( )

    () ()

    () ()

    (3)

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    ()

    () ()

    3 1 2 2 0 0 0 0 0

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    5%

    10%

    JCR

    (/

    )

    0 0 0 0 0 9/11 0

  • 143

    ()

    ()

    ()

    ()

    2

    4. 2014

    , exosome prep, detection, miRNA

    , tool

    5.

    ()

    miRNA

    miRNA

  • 144 2015 6. 2015

    1) '15 /

    -

    - miRNA

    -

    -

    - miRNA

    -

    2) '15

    3) 2

    4)

    - ,

    -

    7.

    1)

    2) /

    3) (16 )

    4) ()

    RIE(384, 2013)

    E-beam Evaporation System(396, 2013)

    (292, 2013)

    5)

    15: 2, 16: 2, 17: 1, 1

  • 145 8.

    / 14 / 15/ 3 /

    20% 30% 70%

    miRNA 10% 30% 70%

    9. ()

    2012

    2103

    2014

    2015

    2016

    2013.12015.12

    1,300 1,300 1,300 3,900

    1,300 1,300 1,300 3,900

    1,300 1,300 1,300 3,900

    1,300 1,300 1,300 3,900

    10.

    ELISA, , NTA

    exosome

    exosome

    1,000 target ID endcoding

    miRNA protein profiling, high

    throughput drug screening

    miRNA

  • 146 2015

    1.

    2.

    , , 3D

    ,

    -

    -

    -

    - mGRASP 3D

    -

    -

    /

  • 147 2015 1 2017 12

    - '15 2015 1 2015 12

    10,500 ()

    - '15 3,500 ()

    3. 2014 ()

    4. 2014

    5.

    6. 2015

    1) '15 /

    : (mGRASP),

    (), ,

    - mGRASP

    -

    -

    2) '15

    3)

    ( 17)

    4)

    - () ETRI, KAERI,

    , , KAIST, ,

    7.

    1)

    - ,

  • 148 2015 2) /

    ( , BT IT)

    3) (16 )

    ,

    4) ()

    Airyscan

    Light Sheet Microscopy

    Spinning disk confocal microscopy

    5)

    ( 20)

    8.

    / 14 / 15/ 3 /

    10% 25% 80%

    9. ()

    2012

    2103

    2014

    2015

    2016

    2015.12017.12

    3,500 7,000 10,500

    3,500 7,000 10,500

    3,500 7,000 10,500

    3,500 7,000 10,500

  • 149 10.

    -

    -

    - , ,

  • 150 2015 []

    Brain Damage , ,,

    1.

    2.

    Brain Damage

    -

    - ,

    , , , ;

    -

    ,

    ,

    /

  • 151 ,

    2013 2017(1 3)

    - '15 2015 1 2015 12

    2,144,000()*

    - '15 5,000()**

    *() (12)**2015 (20,271)

    3. 2014 ()

    (, , , )

    1) (SCI 9)

    - - DHED

    (Korean J Physiol Pharmacol. 14.2)

    - S100A9 (Tg2576)

    (PLoS One. 14.2)

    - MAP2

    (Rev Neurosci, '14.4)

    - RNAi (Nat Commun, '14.4)

    - III -G-GPR56-RhoA

    (PLoS One. 14.6)

    - VEGFR2

    -1 (eLife, '14.9)

    - (Am J Pathol, '14.9)

    - TGF

    (J Neurosci. '14.11)

    - 5

    (J Neurosci, '14.12)

  • 152 2015 2)

    ()

    1 S100A9 NRF2014.05.012015.04.30 45,630

    2 GPR - NRF2014.06.012015.05.31 45,630

    3 synucleins NRF 2014.06.012015.05.31 50,916

    4 ALS/FTD , TDP-43 NRF2014.06.012015.05.31 49,810

    5 ,

    2014.08.202015.08.19 63,500

    6 (ASD)

    NRF 2014.09.012015.08.31 36,830

    7Decoding global networks underlying Tourette symptom subtypes using PET and electrophysiological methodologies

    TSA 2014.09.012015.08.31 77,722

    8 NRF 2014..11.012015.04.30 24,905

    9 NRF2014..11.012015.04.30 24,905

    10 NRF2014..11.012015.04.30 24,905

    11 CLC-ec2 ,

    NRF 2014..11.012015.04.30 24,905

    12 NRF2014..11.012015.04.30 24,905

    13 RNA NRF2013.12.012014.11.30 54,990

    14 -

    /

    2014.11.012015.03.31 250,000

    15 NEDD4 NEDD4L -

    NRF 2014.11.012015.07.31 37,995

  • 153 ()

    - MOU 7 KIST ,

    7

    () -ETRI- 3 MOU (14.8, 2014 UKC )

    - ()

    2 ()

    (20)

    ( 17)

    2)

    ( )

    IF 20

    IF 10

    1%

    5%

    10%

    JCR (

    /

    )

    1 5 3 9/16 15

  • 154 2015

    ()

    ()

    () ()

    2 1 2 2 7 1

    4. 2014

    5.

    ()

    Brain Damage

    6. 2015

    1) '15 /

    -

    - -

    -

    - ,

    - ,

    , /

    , ,

    ,

    2) '15

  • 155 3)

    DGIST, UST, -

    -

    ( )

    - , IT, BT, NT

    , ,

    ** UST UST- (2016)

    4)

    SK ( 1)

    KBRI-ETRI-

    (MGH)

    7.

    1)

    ,

    ,

  • 156 2015 2) /

    KIST ETRI , IT

    , (*)* ,

    IBS -

    NIH / NIAID(RML) Dr. Byron Caughey

    DGIST, UST, ()

    , ETRI, (Exosome, extracellular

    vesicle )

    3) (16 )

    3 ,

    - ( )

    - ,

    - ,

    5)

    8.

    / 14 / 15/ 3 /

    10% 80% 10%

    - 20% 80%

    - - 100%

    30% 80% 100%

  • 157

    9. ()

    / 14 / 15/ 3 /

    10% 50% 100%

    - 2% 10% 30%

    20% 60% 100%

    5% 20% 70%

    - 10% 40%

    TDP-43 ,

    10% 30% 70%

    10% 30% 85%

    10% 20% 70%

    (Exosome, EV )

    5% 10% 50%

    10% 20% 85%

    10% 25% 65%

    2013

    2013

    2014

    2015

    2016

    2013.1

    3,000 5,000 5,000 13,000 3,000 5,000 5,000 13,000

    3,000 5,000 5,000 13,000 - 3,000 5,000 5,000 13,000

  • 158 2015 10.

    ---

    , ,

    , ,

  • 159

    1.

    2.

    ,

    ,

    -

    - (Serial Face Block SEM

    TIRFM 7 )

    - ()

    (

    )-()-( )

    ( 10870)

    /

  • 160 2015

    2013 2017(1 3)

    - '15 2015 1 2015 12

    2,144,000()*

    - '15 3,800()*** () ('12)

    ** 2015 (20,271) ( 3,000,

    800)

    3. 2014 ()

    1) (, , , )

    ()

    - (14)

    MOU (3)

    - (14.3), (14.11), (14.12)

    2)

    ( )

    IF 20

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    1%

    5%

    10%

    JCR (

    /

    )

  • 161

    ()

    ()

    ()

    () ()

    () ()

    (3)

    35

    ()

    ()

    () ()

    3

    4. 2014

    5.

    ()

    6. 2015

    1) '15 /

  • 162 2015 - ( )

    -

    - ,

    , DB(Brain Library)

    -

    /

    -

    ()

    -

    -

    - ,

    - fMRI, PET/CT

    - ,

    ,

    2) '15

    3)

    4)

    -

    ---

  • 163 -

    - ()

    ( , )

    -

    7.

    1)

    ,

    --

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  • 164 2015 3) ('16 )

    fMRI, PET-CT

    8.

    9. ()

    10.

    ,

    --

    ,

    2013

    2013

    2014

    2015

    2016

    2013.1

    3,000 3,500 3,000 9,500 3,000 3,500 3,000 9,500

    ()

    2014.1

    800 800 1,600

    800 800 1,600

    2016.1

    500 500 500 500

    3,000 4,300 3,800 45,130 3,000 4,300 3,800 45,130

  • 165 []

    1.

    /

    2.

    - circulating miRNA

    - miRNA

    - circulating miRNA

    - microRNA

    circulating miRNA 1

    2 ('08'17)

    2012 1 2015. 12

    - '15

  • 166 2015 1,893()

    - '15 300

    3. 2014 ()

    1) (, , , )

    - KO

    Cas9 CRISPR (G3, 2014)

    -

    (Trends in Endo. & Met. 2014)

    -

    (2014. 06.262019.06.25., 5 (3+2), 15(3/)

    - PCT : DYRK1A

    (2014 10, PCT/KR2013/000329)

    - :

    (2014 4, 10-1392942), DYRK1A

    (2014 9, 10-1447560)

    - : Dyrk1aa

    (2014 7

    2014-009480)

    - (UST , )

    - (4)

    ()

  • 167 2)

    ( )

    IF 20

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    1%

    5%

    10%

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    ()

    () 1 2 1

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    () () (3)

    1 4 10

    4. 2014

    2014 :

    5.

    ()

  • 168 2015

    (inter-organ communication) , ,

    6. 2015

    1) '15 /

    miRNA

    - Alzheimer disease

    - miRNA

    - circulating miRNA 1

    2) '15

    3) (1)

    4)

    ()

  • 169 7.

    1)

    - microRNA

    microRNA hit

    - dataset

    microRNA

    - microRNA

    - microRNA /

    2) /

    ()

    (microRNA)

    KIST/ microRNA

    ()

    3) (16 )

    4) ()

    5)

    (1-2015, 1-2017)

    8.

  • 170 2015 9.

    ()

    10.

    - , AD

    miRNA

    AD AD

    - AD GDP 1%

    600

    -

    2012

    2103

    2014

    2015

    2016

    2012.012014.12

    419 719 755 300 1,893

    419 719 755 300 1,893

    419 719 755 300 1,893

    419 719 755 300 1,893

  • 171

    /

    1.

    2.

    /

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    2 (0817)

    2012 01 2014 12

    - '15

    850()

    - '15

    3. 2014 ()

    1) (, , , )

    /

  • 172 2015 - De novo mutations in the motor domain of KIF1A

    cause cognitive impairment, spastic paraparesis, axonal neuropathy

    and cerebella atrophy" (2015) Human Mutation 36:69 (IF 5.44)

    -

    - / PTPRT

    (10-2011-0037335)

    ()

    - Montreal (Human Mutation, 2015)

    - Georgia Regents /

    PTPRT ( )

    2)

    ( )

    IF 20

    IF 10

    1%

    5%

    10%

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    (/

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    1 1

    ()

    ()

    ()

    1

  • 173

    4. 2014

    PTPRT

    5.

    6. 2015

    1) '15 /

    2) '15

    ()

    ()

    () ()

    2

    ()

    /

  • 174 2015 3)

    4)

    7.

    1)

    , , ,

    2) /

    ()

    ( )

    3) (16 )

    4) ()

    5)

    8.

    / 14 / 15/ 3 /

    / 20% 50% 70% 100%

    /

    30% 70% 100%

    / 10% 30% 70%

  • 175 9. ()

    10.

    ( ),

    - /

    - / /

    2012

    2103

    2014

    2015

    2016

    /

    2012.012014.12

    284 276 290 850

    284 276 290 850

    284 276 290 850

    284 276 290 850

  • 176 2015

    1.

    :

    2.

    ,

    -

    -

    - ,

    -

    - /

    -

    -

    - /

    /

  • 177 2 (0817)

    2014. 1 2017. 12

    - '15 2015.01 2015.12

    8,800(, )

    - '15 2,200(, )

    3. 2014 ()

    1) (, , , )

    - Progesterone production is affected by unfolded protein response

    (UPR) signaling during the luteal phase in mice / Life sciences

    - FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential

    Anti-Angiogenic Factor during Zebrafish Vascular Development / PLOS ONE

    - Therapeutically Targeting Neuroinflammation and Microglia after

    Acute Ischemic Stroke / BioMed Research International

    - Mitochondrial ROS govern the LPS-induced pro-inflammatoryresponse in microglia

    cells by regulating MAPK and NF-B pathways / Neuroscience Letters

    ()

    2)

    ( )

    IF 20

    IF 10

    1%

    5%

    10%

    JCR

    (/

    )

    4

  • 178 2015

    ()

    ()

    () ()

    6 1 1

    4. 2014

    5.

    6. 2015

    1) '15 /

    - DJ-1

    -

    - DJ-1

    -

    ()

  • 179 2) '15

    3)

    4)

    R&D

    7.

    1)

    2) /

    SPF

    ,

    , CRISPR/Cas9 design

    knockout

    3) (16 )

    ,

    /

    4) ()

    5)

  • 180 2015 8.

    / 14 / 15/ 3 /

    10% 30% 100%

    - 30% 70%

    9. ()

    2012

    2103

    2014

    2015

    2016

    2014.1-2017.12

    2,200 2,200 4,400 8,800

    2,200 2,200 4,400 8,800

    2,200 2,200 4,400 8,800

    - - - -

    2,200 2,200 4,400 8,800

    10.

    ,

    ,

    / 2

  • 181 []

    1.

    2.

    -

    -

    -

    :

    ()

    2015 01 2019 12

    - '15 2015 1 2015 12

    7,500()

    - '15 1,500()

    /

  • 182 2015 3. 2014 ()

    4. 2014

    5.

    ()

    -

    NDA

    -

    -

    6. 2015

    1) '15 /

    -

    -

    ,

    -

  • 183 -

    -

    -

    -

    -

    -

    2) '15

    3)

    4)

    - ()

    (KIST)

    - ( ,

    , , , )

    - 12

    -

    7.

    1)

    o

    -

  • 184 2015 2) /

    o KIST bio-transformation

    3) (16 )

    4) ()

    5)

    8.

    / 14 / 15/ 3 /

    30% 100%

    9. ()

    2012

    2103

    2014

    2015

    2016

    2015.01.01.~2019.12.31

    - - - 1,500 6,000 7,500 - - - - - - - - - 1,500 6,000 7,500

    - - - 1,500 6,000 7,500 - - - - - - - - - 1,500 6,000 7,500

    10.

    -

    -

  • 185 []

    1.

    /

    2.

    - NMR/MRI

    - / /

    -

    -

    (14.12.30)

    2013. 01. 2015. 12.

    - '15 2015. 01. 2015. 12.

    3,251()

    - '15 1,081()

  • 186 2015 3. 2014 ()

    1) (, , , )

    - NeuroImage(/

    IF 5% ) 5

    - NeuroImage(/ IF

    5% ) 4

    - KRISS (3)

    - 2014

    - 10

    - ,

    (19) (9)

    No. 1 3 2014.03.21 10-2014-0033636

    2 2014.04.17 DE 112012 004 490.8

    3 2014.04.24 US 14/260,750

    4 2014.04.25CN

    201280052725.4

    5 2014.04.25 US 14/262,251

    6 2014.07.07 14/324,472 7 2014.07.16 8 2014.07.30 US 14/446,764

    9 2014.08.29 PCT/KR2014/008049 PCT

    10 SQUID MEG 2014.09.05 10-2014-0119290

    11

    2014.09.12 10-2014-0121324

    12

    2014.09.12 10-2014-0121328

  • 187

    -

    No.

    1 2014.03.10 10-1374621

    2 2014.04.16 10-1387999

    3 2014.05.28 10-1403318

    4 2014.05.28 10-1403319

    5 2014.06.20 10-1412739

    6 SQUID 2014.07.04 10-1418339

    7 ECG EEG SQUID 2014.09.04 10-1440458

    8 2014.01.08 10-1351424

    9GNSS ,

    2014.04.15 10-1387659

    -

    SQUID ( BMP )

    - UST 2014

    No.

    13 SQUID 2014.10.14 PCT/KR2014/009612 PCT

    14 2014.10.24 10-2014-0145487

    15 2014.10.24 10-2014-0145495

    16Thin Film Superconducting Acceleration Measuring Apparatus, SQUID Sensor Module, and Fabrication Method of SQUID Sensor Module

    2014.09.05 PCT/KR2014/008351 PCT

    17System and Method for Measuring Magnetocardiogram of Small Animal

    2014.12.26.

    U.S. Patent Application No. 13/504,873

    18 12 19 2014.10.30 10-2014-0149486

  • 188 2015 ()

    ()

    PTB (Div.8.2) NMR/MRI

    -

    SQUID NMR NMR

    - (Applied Physics Letter)

    - (ASC2014, Biomag2014)

    - (IEEE Trans. Appl. Supercond.)

    PTB (Div.8.2) NMR

    - -

    NMR

    - PTB 2 KRISS (1);

    Dr. Burghoff, Dr. Koerber - KRISS 1 PTB

    (3); - (Journal of

    Magnetic Resonance)

    Princeton Univ.

    -

    - (NeuroImage)

    Univ. of Maryland

    Tokyo metropolitan Univ.

    DBS

    Spatial filtering

    NPL rf

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  • 191

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  • 198 2015 2)

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  • 203 - (LTD) tau ,

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  • 212 2015

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  • 214 2015

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  • 216 2015 10.

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