목차 - kbri.re.kr…„도 뇌연구촉진... · Ⅰ. 계획수립의 배경 ∙ ∙ ∙ 추진...
-
Upload
phungthien -
Category
Documents
-
view
235 -
download
0
Transcript of 목차 - kbri.re.kr…„도 뇌연구촉진... · Ⅰ. 계획수립의 배경 ∙ ∙ ∙ 추진...
-
contents
. 1 3 4 2 2 5 2 2 8
. 2014 11 13 15
. 17 19 24
. 2015 27 15 29 30 32 33 41 43
44
2014 44 61
: 2015 63
-
.
2 2 2 2
-
. 3
I
1
2 2(1317)
:
, ( 5)
( 6)
: , , , (14)
99.7 : 1 (9807)
07.12 : 2 (0817)
- 2017 7
13.6 : 2 (2, 1317) (13)
14.4 : 2014 (14)
2 2('13'17)
2015
-
4 2015
( 14)
, R&D ,
2
-
. 5
2
3 2 2
-
6 2015
2
2
1 R&D , , 3
2 2
3 2
-
. 7
2
- (1317) 6,245()
'07 (1 5,000: '08'17) 61.9% ( )
( : ) * IBS** *** 2013 561 200 103 8642014 589 200 360 1,1492015 619 200 443 1,2622016 650 200 561 1,4112017 682 200 677 1,559 3,101 1,000 2,144 6,245
-
8 2015 * '13 561 ('12'16) (5%)
** 2 IBS (13 50% )
*** ()( : ('12, ())
- (17 9,300)
, ,
< >( : )
12 13 14 15 16 17
2,844 3,603 4,565 5,784 7,329 9,286
*
* 17 1 (15%)
- 12 22.0% 17 30%
4 2 2
-
. 9
()
( 12844, 14.11.19)
6( ) 14( )
6 ( )
( "" ) .
.
.
.
14 ( )
.
1. : ,
, ,
,
12. :
,
2. :
3. : ()
( 25751, 14.11.19)
4( )
4( ) 62
( "" )
2
.
-
. 2014
-
. 2014 13
II 2014
1
1,045('14 -2.6% )
'14 : 1,073
(SCI DB )- IF20 IF10 1%10%
129
- 59.9% 14 17.9%
( 156, 90)
- 45('14 13.5%), 10('14 37.5%)
2,426
() 310 - 113, 197
66- 51,
- 15
24
6,591 (, )
() 2014
-
14 2015
() 14 : 105,354
- 75.2% (79,237)
() 47.4% (49,982)
- 13.9% (14,643)
- 6.0% (6,301)
- 4.9% (5,173)
< 2014 >( : )
()
15,586(5,096)
30,661(24,406)
23,979(17,725)
9,011(2,756)
79,237(49,982)
- - 14,643 - 14,643
1,514 1,290 1,761 1,738 6,301
- - - 5173 5,173
17,100 31,950 40,383 15,921 105,354
- 38.3% (40,383)
- 30.3% (31,950)
- 16.2% (17,100)
- 15.2% (15,921)
-
. 2014 15
1)
IF20 IF10 1%10% 129
- 106( 56), 14, 9
- IF20 7, IF10 38
, 2 93%(120)
156, 94 59.9%
45, 10 22.2%
: 2,426
: 113, 197
: 66
- 51, 15
: 24
2)
, ,
6,591
2
-
16 2015 < 2014 >
() ()()
()
IF20IF10 JCR
()
1%5%10%
62 27 12 53 14 6118
/86911
- - - 50 88 7622 10 21
10 6 3 2- 6 230/
417 - - - 23 41 1193- 1 7
49 35 13 11 5 304/
304 1 2 40 14 57 138- 1 2
16 9 - 0- -
- 4 4 42 - - 124- - -
KIST 8 5 5 21 6
34/54 - - - 19 9 1124 8
- - - -
- 19/16 - - - - - 35
5 3 -
2 3 1 -- - -
7/9 - - - - 1 10- - -
8 9 11 -- - -
11/22 - - - - - 17- - -
- - - -
- -- - - - - - -
- - -
IBS 2 - - -2 6
11/16 - - - 7 1 355 15
157 94 45 107 38 6724/
87749 5 6 82 113 197 2,4267 24 53
/ /
-
.
-
. 19
III
1
1990 10(Decade of the Brain) , 1
- 2013 Brain Initiative"
( )
20042005 : ,
20062008 : , ,
20092010 : NIH Blueprint for Neuroscience
(Grand challenge)
Blueprint Grand Challenge (09), (10)
2013. 2 :
'Brain Initiative
Brain Initiative 10 30 ( 32)
( )
(NIH) 16
Blueprint for neuroscience
research*
*
-
20 2015 ( )
, ,
- (09) :
, , , UCLA
- (20092010) :
- (2010) :
- (20102011) :
- Brain Initiative (2013) :
(National Alzheimer Project Act
Law) (11.1.4 )
2025. 12. 31 .
, , ,
( )
14 NIH 311 ,
50
(8), (4)
- '13 "Brain Initiative(Brain Activity Map)"
10 30( 3 2)
2014(4)
EU
(FET )
(Human Brain Project, HBP)
-
. 21 -
(Research council)
, (Welcome Trust)
- Welcome Trust-MRC
3 ( 6) ('08.10)
, ,
MRC Neuroscience and
Mental Health Board(NMHB)
(iPS)
- CNRS() INSERM(
)
400
7 (FP7) NAD(Nanoparticles for the therapy and diagnosis of Alzheimer's disease)
- MPI()
-
22 2015
MPI, PET-MRI
Computational Neuroscience Bernstain
Award (06)
EPFL Blue Brain Project
(BBP) , HBP
21
(1997~2016)
- 98 ` (Brain Science Institute)'
(RIKEN) , , ,
,
: (OIST), (NIPS) : RIKEN BSI, RIKEN
2009
300
2004 NT, IT
2014 Brain/MINDS 1 30, 2 40
-
. 23
- 9 2 ( ,)
- 13 10
Shanghai Institutes of Biological Sciences(SIBS)
(ION) * *
< >
Decade of Brain (90)- NIH (National AlzheimerProject Act: NAPA)'(11)
Brain Initiative(13)-
(0711)
- 7 council Ageing brain"-
(ips)
(96) (97)
(07) (08)
Brain/MINDS (14)
(98) 2 2 (1317)
(08) (15)
50(14)( 16%)
17,580(13)( 20.8%)
3(10)/(BT 7%) Brain/MINDS(1 30,
2 40)
1,045(14)(BT 4.5%)
NIH 16
Brain Research UK(11)-
RIKEN BSI(98 )
KIST (11)IBS (3)(1213)
NIH MRC
-
24 2015
1
2014 1,045 2 3 4.5% : (16%), (7%),
(20.8%)
98
('10 630) : 1.26%*, 21%**
* NIH() 50 (1,060/), ** 300(10/)
2012 2(1317) 2
-
2
-
. 25 () BT R&D 5
(13)
- BT *
* , , ,
-
(World Class Institute: WCI)
KIST (0914)
* 70/
KIST (11) (IBS)
(12)
,
-
26 2015 < (0714) >
(: )
/
200713,399
(32.6%)
5,506
(13.4%)
15,605
(38.0%)
3,924
(9.5%)
2,690
(6.5%)
41,124
(100%)
200812,563
(26.4%)
7,411
(15.0%)
13,066
(25.5%)
8,353
(17.0%)
7,935
(16.1%)
49,268
(100%)
200911,031
(19.7%)
8,961
(16.0%)
21,563
(38.5%)
8,325
(14.9%)
6,078
(10.9%)
55,958
(100%)
20109,602
(15.2%)
8,522
(13.5%)
30,644
(48.7%)
6,925
(11.0%)
7,282
(11.6%)
62,975
(100%)
201112,093
(17.7%)
7,505
(11%)
33,669
(49.2%)
9,275
(13.5%)
5,920
(8.6%)
68,462
(100%)
201210,733
(16%)
7,403
(11%)
33,066
(49%)
7,039
(11%)
7,550
(11%)
66,841
(100%)
201316,223
(18.6%)
20,193
(23.1%)
42,606
(48.8%)
8,368
(9.6%)
87,390
(100%)
201417,100
(16.2%)
31,950
(30.3%)
40,383
(38.3%)
15,922
(15.1%)
105,354
(100%)
:
-
. 2015
15
-
. 2015 29
2015
1 15
3 15
1,267
987
( 596)
67
141
72
< / 2015 >
( : )
1
R&D
2
3
()
55,784(28,780)
15,271(15,271)
27,617(15,581)
98,672(59,632)
6,668 6,668
14,111 14,111
7,199 7,199
76,563 15,271 34,816 126,650
-
30 2015
2
1) 15
() (14) 105,354 (15) 126,650(20.2% )
() 77.9%(98,672)* ,
11.1%(14,111), 5.7%(7,199),
5.3%(6,668)
* () : 47.1%(59,632)
4.5%,
(10.3%), (4.1%), (3.1%),
(1.7%)
39.2%(2,026), 24.5%(19,435),
5.8%(367), -3.6%(-532)
< 2015 >( : , %)
15 14
(%)
()
22,782(10,595)
33,526(24,575)
30,087(21,136)
12,278(3,327)
98,672(59,632)
79,237(49,982)
24.5(19.3)
1,580.5 1,580.5 1,926.5 1,580.5 6,668 6,301 5.8
7,199 7,199 5,173 39.2
14,111 14,111 14,643 -3.6
24,362 35,106 46,125 21,058 126,650 105,354 20.2
-
. 2015 31 2)
2015
36.4% 46,125
(36.4%), (27.8%),
(19.2%), (16.6)
42.5% (7,262),
32.3% (5,136)
-
32 2015
3
*
-
, ,
,
- () , ---
()
* ,
IBS , KIST
2
2
() (34 )
*
- ()
) (10)
-
. 2015 33
(14 77,037 15 96,172, 24.5% )
2015
4 (, , , )
8
2 2 (1317) 4 (, , , )
8 ()
(/15/3,620)()
(/1519(5)/22,700 )(-4 ) (7T MRI)
(/1418(5)/5,000 )(-)
(/1418(5)/30,000 )()
(15/4,700)
(13,968), (1,000)
() (15/20,271)
3 IBS (15/25,701)()
4
-
34 2015 (14 6,301 15 6,668, 5.8% )
2015
14,000
BK21 : 250
(14 5,173 15 7,199, 39.2% )
2015
- - /
- PC Mobile Device
Agent App
- / -
- 1 3D
-
-
. 2015 35 (14 14,643 15 14,111, 3.6% )
2015
- (, )
- ,M.D.-Ph.D.
- , Imaging Surrogate Marker
- ,
- , , , , 5
- , , - ,
-
36 2015 (14 5,146 15 8,578, 66.7% )
2015
/
- - -
/ - -
- -
- (FLIPR) - (S1P1/5) - S1P1/5 - (Nrf2) - (EAE) in vivo
- - miRNA -
- (mGRASP)
-
-
. 2015 37 -
: - , , 3D ,
(14 14,559 15 20,271, 39.2% )
2015
Brain Damage
Brain Damage - - , ,
,
- () Serial Face Block SEMTIRFM 7
- () () /
- () , (/ ) ( )
-
38 2015 (14 3,245 15 2,500, 23.0% )
2015
miRNA
()
miRNA - Alzheimer disease - miRNA
(14 0 15 1,500)
2015
,
-
. 2015 39 (14 1,098 15 1,081, 1.5% )
2015
- NMR/MRI
- / /
-
(14 25,934 15 25,702, 0.9% )
2015
,
(Synaptic adhesion molecule)
(Synaptic signaling scaffold)
(knock-in mice)
simple system deliberate system
CA3
-
-
40 2015
MRI/fMRI
LED
-
. 2015 41
() BT&ICT
8
, ,
,
()
14 : 3,500; 14 : 2,426
67%
()
14, IF20 IF10 1%10% 129,
JCR 2,100( 6% )
()
14 306, 11
151 (48%), (29%), (12%), (11%)
()
11 3,000/14 3,500 11.6% (
)
310, () 43( 83%,
14%, 3%) 13.9%
5
-
42 2015
()
() (
)
()
(75%) (46%)
()
()
-
. 2015 43
6
2015
2015
2015
2016
2016
-
44 2015 1 2014
IBS
/
1.
.
.
2.
.
3.
.
-
.
-
.
- Proc. Natl. Acad. Sci. USA (2014)
.
-
. 2015 45
IBS
/
1. (Trk)
,
.
2.
,
.
3.
,
.
- ,
.
- .
- Nature Communications (2014)
- Molecular & Cellular Oncology (2014)
,
.
-
46 2015
IBS /
1.
.
2.
( )
.
3.
,
.
- ,
.
- .
- Nature Methods (2014)
- Trends in Biotechnology (2014)- Nature Reviews Molecular Cell Biology (2014)
.
.
,
-
. 2015 47
NGL-3 /
(synaptic protease)
, NGL-3
(synaptic adhesion molecule) ,
(, long-term depression LTD)
.
LTD(chemical LTD) .
(LTD)
.
Phil. Trans. R. Soc. B. (2014)
NGL-3
NGL-3 /
-
48 2015
(crack) /
1. (Lyriform slit organ)
(crack)
2. (crack)
,
,
lab on a chip
3.
1,000 (2% )
,
(crack)
lab on a chip
-
. 2015 49
Glucose Transport & metabolism MRI /
1.
2.
glucose transport metabolism
3. MRI
protein, peptide, neurotransmitter
PET (Positron Emission Tomography) glucose
MR spectroscopy 100
biomarker
-
50 2015
/
/
1. , , ,
,
2.
,
3. REV-ERB (NR1D1)
, /
,
(mania)
4. REV-ERB
First-in-Class
-
,
-
- : Chung et al., 2014, Cell 157:858
- :
2 ( 10-2014-0055117
10-2014-0055121)
REV-ERB
. /
/ 30~60%
,
/
-
. 2015 51
3
/
1.
, CA3 CA1
.
2.
(mGRASP) 3
CA3 CA1 3
3.
1:1 CA3, CA1
.
4.
,
(WCI)
-
1:1
- ,
,
- : Neuron (2014)
Nature Protocols (2014)
(mGRASP) 20nm
.
3 3
,
3
3D Data Base , , ,
-
52 2015
/
1.
,
2.
-B
3. -B
,
(WCI)
Flagship
- -B
,
.
- -B
,
- : Nature Medicine (2014)
- :
(: 10-1438532, : 5589037)
-B , ,
.
.
,
,
MAO-B, Best 1
-B
-
. 2015 53
/
1.
,
2.
3.
4. (TWIK-1)
(TREK-1)
,
(WCI)
-
, ,
-
- : Nature Communications (2014)
,
.
-
, ,
,
-
54 2015
NASA/
1.
2. 100 nanomole
3.
,
4.
5.
,
4: U.S. Patent No: 8,909,491 (2014),
PCT/KR2008/002663 (2010), PCT/KR2008/002662
(2010), PCT/KR2008/002662 (2010)
2: 10-1351779 (2014), 10-1351794
(2014)
NASA Langley Research Center
NASA
1mm3
image sensor
1/100
-
. 2015 55
(, , , )
, ,
Medtronics
Localized Field Potential
. ,
,
,
,
,
, , , , .
, polymer film quality check, ,
,
,
2015
-
56 2015
GluA2- AMPA
/
1. ,
3
2. -
GluA2- AMPA
3. GluA2- AMPA 15
76%
4. , (14 8, 9), PLoS One
(14 8)
- ,
.
- . GluA2-
AMPA
- Nat Neurosci (2013)
- PLoS One (2014)
GluA2- AMPA
GluA2- AMPA
.
( , , )
/
/
-
. 2015 57
S100A9
/
- S100A9
,
- S100A9
-
microglia tumor necrosis
factor(TNF)-, Interleukins (IL-6, IL-10)
- ,
Tg2576 x S100a9K/O in vivo
,
- PLOS ONE (2014)
S100A9 ,
-
58 2015
/
.
(
)
/World Class Laboratory(WCL)
-
- NeuroImage (2014)
- 2014 YTN, , MBC, , 30
- / //
( 7, 10)
- BIOMAG2016
- SQUID NMR
- -
- 10
K-step , /
, ,
,
( )
-
. 2015 59
G lucocerebrosidase depletion enhances cell-to-cell
transm ission of -synuclein /
1. (PD) -synuclein
,
2. Glucocerebrosidase
-synuclein
3. Glucocerebrosidase
-synuclein
(PD) -synuclein
Glucocerebrosidase
-synuclein
-synuclein
-
60 2015
Direct cellular delivery of human proteasomes
to delay tau aggregation /
1.
()
2.
()
(SiO)
3.
-
-
-
. 2015 61
2
14 15
2,000 1,000
- 02.9 2,000 1,000
14,060 24,072
- 06.11 14,060 24,072
13,195 13,968
- 00 3,771 3,360
- 86 7,188 8,372
- 97 2,236 2,236
1317
5,146 8,578
- 5,146 8,578
09.6
14,559 20,271
- 14,559 20,271
3,245 2,500
- 12.114.12 755 300
- 12.114.12 290 -
- 14.117.12 2,200 2,200
13.115.12
1,098 1,081
- 1,098 1,081
15.119.12
- 1,500
- - 1,500
(IBS) 25,934 25,702
- 12.716.12 7,934 7,902
- 12.816.12 6,000 5,800
- 13.717.12 12,000 12,000
79,237 98,672
[] [49,982] [59,632]
89
3,979 4,346
- 3,979 4,346
BK21 13.920.8
2,322 2,322- BK21 2,322 2,322
6,301 6,668
13.616.7
- 3674 5326(1499) (1873)
5,173 7,199
(R&D)13
- ()14,032 13,500(611) (611)
14,643 14,111
()105,354 126,650(2,110) (2,484)
-
2015
-
65 1.
[]
(, MRC)
1.
:
10 , 7(4+3)
- -
6()
( )
- 22
2002 9
- 15 2015.3.1.2016.2.28 / 2015.9.12016.8.31
214,551(, 14 )
- 15 33,100() / ( 1,000)
2. 2014 ()
1) (, , , )
NeuroimageIdentifying neuropathic pain using 18F-FDG micro-PET: A multivariate pattern analysis
2014.02.01.
Cell death & Differentiation
Crucial role of calbindin-D28k in the pathogenesis of Alzheimers disease mouse model
2014.05.23.
-
66 2015
1
2 3
()
2014 ()
8 9 400 9 19 3
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
2 1 35
Nucleic Acids Research
ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription
2014.02.01.
-
67
()
()
()
4 3
() ()
() () (3)
2 1 69
()
()
() ()
8
3. 2014
4.
()
-
-
68 2015 5. 2015
(MRC)33,100, 31, 3
( )
- 1(1,000)
6.
7.
/ 14 /15/
3 /
- 50% 70% 100%
50% 70% 100%
8. ()
2012
2103
2014
2015
2016
(MRC)
02
154,851 29,750(2,000)29,950(2,000)
33,100(1,000) 34,000 281,651
154,851 29,750(2,000)29,950(2,000)
33,100(1,000) 34,000 281,651
154,851 29,750(2,000)29,950(2,000)
33,100(1,000) 34,000 281,651
154,851 29,750(2,000)29,950(2,000)
33,100(1,000) 34,000 281,651
-
69 9.
Brand
-
70 2015 []
, ,,
1.
O O
/
O O
2.
,
4
: 4 (
, , )
* 9( ), 2
(, (), )
2006. 11
- '15
14 56,110
- '15 240.72()
-
71 3. 2014 ()
1) (, , , )
- (/) * Cell ('14. 5, IF 33.116) -
( /)* JCI ('14. 5, IF 12.812)
- Sox2 Sox6 (/)
* PNAS ('14. 2, IF 9.809) -
(/)* Plos Biol ('14. 10, IF 11.771)
()
14 *
14.819.7 4,500 30,000
/ 14.1019.9 1,000 22,700
7T MRI
14.719.6 1,000 5,000
*
- (NASA/) * (U.S. Patent No: 8,909,491, 2014 11)
-
72 2015 - GluR2- AMPA (/
)
* , ('14. 8, 9)
- 14( 6, 8) 1
, ( 2)
()
-(Asan International Symposium on Diabetes,
Obesity and Metabolism) (/)* 14 7() , 6 150
2)
( )
* 1014
()
()
()
38 14 7 5
IF 20
IF 10
1%
5%
10%
JCR
(/
*)
1 4 2 5 0.27(112/414) 3
-
73
() ()
() ()
(3)
26 32 36 5 603
()
()
() ()
2 1
4. 2014
5.
()
,
-
74 2015
()
biomarker
subtype EEG
biomarker
fMRI -
Encoding Retrieval
-
75
()
/ 3D
MEMS
, ,
-
RF
RF
/
/
SiPM
PET/MR
-
76 2015
()
7T PET/MR , ,
/
FAM19A5
/
-
77
()
/
/
vocoder -
-
78 2015
()
,
/
Microtubule
mTOR
non-coding RNA
ephrin/Eph/mTOR
mTOR
-
79
()
NAD+
NAD
, ,
-
80 2015
6. 2015
1) 15 /
(15 47)
()
O
RF
-
81 - ()
(15 36.12)
- ()/
,
2) 15
3)
2 2 (1317)
- / 122 ( 1 0.77, )
4)
//
7.
1)
()
, ,
4 BT, IT, CS()
() 4
8
2) /
, , ,
,
3) (16 )
16 (67 )
-
82 2015 - 4 (, ) 2
( 30 )
-
(10 )* , ,
17 (55 )
- 4 2 ( 27 )
4) ()
()
2015.2()
3
() 3
* 5)
2013 2014 2015 2016 2017
()
60 58 122 173 229
* ( 1 `16 0.81, `17 0.86)
8.
/ 14 / 15/3
/
80% 120% 200%
10% 30% 70%
60% 80% 100%
60% 80% 100%
-
83
/ 14 / 15/3
/
60% 80% 100%
10% 30% 50%
/ 70% 100% 100%
/ /
10% 20% 70%
70% 100%
50% 85% 100%
50% 85% 100%
50% 85% 100%
40% 85% 100%
/ 3D 30% 50% 100%
MEMS 40% 60% 100%
RF
RF
20% 60% 100%
10% 70% 100%
/
30% 60% 100%
-
84 2015
/ 14 / 15/3
/SiPM 20% 60% 100%
20% 40% 100%
PET/MR 0% 0% 100%
7T PET/MR 0% 20% 100%
10% 40% 80%
0% 10% 40%
10% 30% 60%
/ 10% 30% 70%
0% 10% 30%
50 70 100
60 80 100
FAM19A5 30% 50% 100%
10% 30% 70%
10% 30% 70%
neurotool 30% 60% 100%
30% 60% 100%
-
85
/ 14 / 15/3
/
30% 60% 100%
-
10% 30% 60%
10% 30% 50%
20% 50% 100%
, 10% 30% 70%
40% 60% 100%
40% 60% 100%
40% 60% 100%
vocoder - 10% 20% 70%
,
30% 20% 50%
10% 20% 70%
30% 70% 100%
/
0% 30% 70%
0% 10% 90%
mTOR / 10% 20% 70%
-
86 2015
/ 14 / 15/3
/
10% 40% 50%
ephrin/Eph/mTOR
10% 30% 60%
mTOR
10% 40% 50%
50% 100%
20% 60% 100%
30% 70% 100%
35% 70% 100%
70% 100%
NAD+
20% 40% 70%
NAD
10% 30% 70%
10% 30% 90%
20% 30% 70%
0% 30% 70%
-
87
9. ()
2012
2103
2014
2015
2016
06~
32,940 9,110 14,060 24,072 60,144 140,326
32,940 9,110 14,060 24,072 60,144 140,326
32,940 9,110 14,060 24,072 60,144 140,326
32,940 9,110 14,060 24,072 60,144 140,326
/ 14 / 15/3
/
0% 30% 70%
0% 30% 70%
30% 90% 100%
BMBI
100%
80% 100%
80% 100%
80% 100%
80% 100%
-
88 2015 10.
SCI 06 13 12 10
(: 2 (0817))
BT, IT, NT CS
-
89 []
1.
(, )
2.
-
-
,
( )
( 7 40 )
( )
(
)
(),
25
-
90 2015 : (, )
:6()
( )
2000
- '15 2015512016430, 2015612016531,
2015712016630, 2015812016731,
201511120161031, 201512120161130
- '15 142,500( 3,360)
3. 2014 ()
1) (, , , )
Remote Control of Gene Function by Local Translation(Cell, 2014.3)
Impact of Circadian Nuclear Receptor REV-ERB alpha on Midbrain
Dopamine Production and Mood Regulation(Cell, 2014.5)
20
11, 3
4, 28
()
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
2 5 2 5 10 20
-
91
()
()
()
9 3 2
() ()
() ()
(3)
5 28 100
()
()
() ()
4. 2014
2014 R&D
5.
6. 2015
2015 ( 40(2,000),
106(3,360))
7.
-
92 2015 8.
9. ()
2012
2103
2014
2015
2016
()1999~
135,349(3,674)146,100(4,283)
141,937(3,771)
142,500(3,360)
166,000(5,360)
731,886(20,448)
- - - - - -
135,349(3,674)146,100(4,283)
141,937(3,771)
142,500(3,360)
166,000(5,360)
731,886(20,448)
135,349(3,674)146,100(4,283)
141,937(3,771)
142,500(3,360)
166,000(5,360)
731,886(20,448)
- - - - - -
135,349(3,674)146,100(4,283)
141,937(3,771)
142,500(3,360)
166,000(5,360)
731,886(20,448)
( )
10.
-
93
1.
(, )
2.
,
-
-
-
,
(, )
6(
)
( )
1986
-
94 2015 14 30,198
- 15 388,295
3. 2014 ()
1) (, , , )
- Glucocerebrosidase depletion enhances cell-to-cell transmission of
alpha-synuclein(Nature Communications)
- Extracellular alpha-synuclein-a novel and crucial factor in Lewy
body diseases(NATURE REVIEWS NEUROLOGY)
* 2014 50 ( )
- Subcellular Neural Probes from Single-Crystal Gold Nanowire(ACS Nano)
47
-
- 15
- ,
6
- ()Brain image analysis using MRI
()
- , 16
( 24, 15)
()
- (2nd IEEE International Winter Workshop on Brain-Computer
Interface)
-
95 2)
( )
IF 20
IF 10
1%
5%
10% *
JCR ** (/
)
3 4 5,997/86,421 47
* IF 9
** (2014)
(2014 SCI 1 )
()
()
()
15 6 1
() ()
() ()
(3)
15 24 2
()
()
() ()
3 1
-
96 2015 4. 2014
2014 A
- ()
, 13
5.
( )
6. 2015
-
- 388,295( 1,556, 1,024 )
- 8,372( 60 ), (50, 70
(2014 ))
7.
8.
9. ()
2012*
2103
2014
2015
2016
86~
314,677 348,795 388,295
314,677 348,795 388,295
314,677 348,795 388,295
314,677 348,795 388,295
* 2014 30,198 / 2016
-
97 10.
( )
-
-
( )
-
( )
( R&D )
-
98 2015
1.
/
2.
- ()
- ()
- () 58 , 9(3+3+3)
- () 15 , 10(5+5)
-
6(
)
( )
-
99 (1997), (2005)
- '15
() 15. 3. 1.16. 2. 29
() 15. 9. 1.16. 8. 31.
- '15 56,736() ( 2,236)
3. 2014 ()
1) (, , , )
Philos Trans R Soc Lond B
Biol SciShank mutant mice as an animal model of
autism 2014.01
Philos Trans R Soc Lond B
Biol Sci
NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that
are induced by different patterns of stimulation
2014.01
Mol Cells Neuronal Activity-Dependent Regulation of MicroRNAs 2014.07
NeuronCoexistence of two forms of LTP in ACC provides a synaptic mechanism for the
interactions between anxiety and chronic pain2014.12
3
2
5
-
100 2015
()
() ( )
()
ApCPEB4
3
Columbia Eric
Kandel( )
6
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
2 1 1 9/76
()
()
()
() ()
() ()
(3)
2 3 1
-
101
()
()
() ()
5 2 3 1
4. 2014
2014 R&D
-
- 1 , IF
, .
5.
()
-
,
()
-
-
102 2015 6. 2015
1) '15 /
-
,
-
-
.
,
Ribosome Footprint Profiling(RFP)
-
-
, mRNA
- RPF mRNA
,
(Optogenetics)
- ,
-
-
103 2) 15
3)
5 ()
4)
ACC University of
Torronto
7. 1)
-
2) / - .
3) (16 ) 4) ()
()
150
-
104 2015
5)
2014 3, 2
2015-
2016 4
2017 1
8.
9. ()
2012
2103
2014
2015
2016
97
525,164(2,042)45,700(736)
46,368(736)
51,736(736)
70,000(736)
738,968(4,986)
0
525,164(2,042)45,700(736)
46,368(736)
51,736(736)
70,000(736)
738,968(4,986)
05
45,979(1.500)5,200
(1.500)5,000(1.500)
5,000(1.500)
5,000(1.500)
66,179(7,500)
0
45,979(1.500)5,200
(1.500)5,000(1.500)
5,000(1.500)
5,000(1.500)
66,179(7,500)
/ 14 / 15/ 3 /
10% 30% 50%
()
140
-
105
14()
2010-2019 736,000
2012-2022 1,500,000
10.
,
,
2012
2103
2014
2015
2016
571,143(3,542)
50,900(2,236)
51,368(2,236)
56,736(2,236)
75,000(2,236)
805,147(12,486)
0
571,143(3,542)
50,900(2,236)
51,368(2,236)
56,736(2,236)
75,000(2,236)
805,147(12,486)
-
106 2015 2.
[]
1.
/
2.
( )
,
2 5
2 5
R&D
( )
(5 )
-
107 ( )
- '15 1
- '15 294,250()
3. 2014 ()
1) (, , , )
-
(Neuropsychopharmacology, 14.9, IF 7.833)
- 16, 462
- ( , 14.1)
- 13
()
- 3
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
2 1 2 71 16
-
108 2015
()
()
()
2 2
() ()
() ()
(3)
7 18 13 9 92
()
()
() ()
2 1
4. 2014 2014
5. ( 10% )
6. 2015 1) '15 /- (3)
2) '15 3) 4)
-
109 7.
1)
2) /
-
3) (16 )
4)
5)
8.
9. ()
2012
2103
2014
2015
2016
89
291,651(5,125)
303,500(4,952)
290,500(3,979)
294,250(4,236)
300,750(4,320)
1,480,651(22,612)
291,651(5,125)
303,500(4,952)
290,500(3,979)
294,250(4,236)
300,750(4,320)
1,480,651(22,612)
291,651(5,125)
303,500(4,952)
290,500(3,979)
294,250(4,236)
300,750(4,320)
1,480,651(22,612)
291,651(5,125)
303,500(4,952)
290,500(3,979)
294,250(4,236)
300,750(4,320)
1,480,651(22,612)
10.
-
110 2015
BK21
1.
()
()
2.
, ,
* , , , ,
2 BK21 (WCU)
'15 2,285 96 316
472 () 13,000
21 400
54 600
-7
- 9 11
- 70. , 103.
()
-
111 2013. 9 2020. 8
- '15 2015. 3 2016. 2
1,900,000()
- '15 273,000()
3. 2014 ()
1) (, , , )
- -()
Chemical Communications
( , 2013.11)
-
Cell ( , 2014.5.8)
- 9
- 4 BK21 () 39,
7
()
- The 6th International Conference on Brain and Cognitive Engineering
('14.6.276.29, )
2)
( )
IF 20
IF 10
1%
5%
10%
JCR (
/
)
1 3 233/233
-
112 2015
()
()
() 47 33 13 1 1 1 2 40 0
() ()
() () (3)
7 39 6 45 7 46
()
()
() ()
22 9 14 3 21 8 0 0 39 0 5
4. 2014
5.
6. 2015
BK21
- ,
()
- BK21
7.
1)
14,000
BK21 250
-
113 8.
()
2012
2103
2014
2015
2016
BK21
13.920.8
138,700(1,394)272,913(2,322)
273,000(2,322)
290,640(2,330)
975,253(8,368)
138,700(1,394)272,913(2,322)
273,000(2,322)
290,640(2,330)
975,253(8,368)
138,700(1,394)272,913(2,322)
273,000(2,322)
290,640(2,330)
975,253(8,368)
138,700(1,394)272,913(2,322)
273,000(2,322)
290,640(2,330)
975,253(8,368)
( )
9.
-
114 2015 3.
1.
/
2.
/
/ ,
,
,
:
11()
2013 62016 10(3 5)
- '15 2015 11 2016 10(12)
-
115 16,676( 12,000, 4,676)
- '15 7,199( 5,326, 1,873)
3. 2014 ()
1) (, , , )
- Reorganization of the Brain and Heart Rhythm During Autogenic
Meditation (Frontiers in Integrative Neuroscience, '14.01)
- Heart Brain Synchronicity As An Integrated Heart Brain Anti-aging
Marke (The 21th International Stress and Behavior Society, '14.02)3.
- Rate of energy consumption during ADL in Korean life style
setting (ISBNPA '14.5)
- An Empirical Analysis on the Performance Factors of Software
Firm (IJSEIA, '14.12)
- ()
(: 10-2014-0037957, '14.03)
- ()
(: 10-2014-0080797, '14.06)
- ()
(: 10-2014-0081331. 14.06)
- ()
(: 10-2014-0028466, '14.03)
- () ,
(: 10-2014-0029891, '14.03)
- ()
(: 10-2014-0026025, '14.04)
- ()
(: 10-2014- 0055615, '14.05)
-
116 2015 - () LVDS Linux SW
HW (8, (), '14.07)- () (13,
, '14.07)- () SW (11,
, '14.07)- () SW(10,
, '14.07)
()
2)
( )
()
()
() 16
(9 )
9( )
0 0 0 4 4 42 0
() ()
() ()
(3)
0 0 0 0 0 124
()
()
() ()
-
117 4. 2014
2 (15.10)
5.
()
6. 2015
1) '15 /
,
2) '15
3)
4) ,,,
7.
1) 15
2) /
3) (16 )
4) ()
5)
8.
/ 14 / 15/ 3 /
/ 85% 90% 100%
-
118 2015 9.
()
2012
2103
2014
2015
2016
(
)
2013.6 ~2016.10
3,000 3,674 5,326 12,000
1,304.2 1,498.641 1,873 4,676
4,304 5,173 7,199 16,676
3,000 3,674 5,326 12,000
1,304.2 1,498.641 1,873 4,676
4,304 5,173 7,199 16,676
10.
/ ,
,
-
119 4.
1.
- ()
- () , ,
, ,
2. 2014
1)
- Glucocerebrosidase mutation -(-synuclein)
* Glucocerebrosidase depletion enhances cell-to-cell transmission of
-synuclein 2014 Nature Communications(IF: 10.74)
- ()
* Direct cellular delivery of human proteasomes to delay tau
aggregation 2014 Nature Communications(IF: 10.74)
- ADHD(Attention-Deficit/Hyperactivity Disorder)
* Connectomic disturbances in attention-deficit/hyperactivity disorder:a whole-brain tractography analysis 2014 Biological Psychiatry(IF: 9.47)
- ( 23 , 2,692 )
-
120 2015 () 19 , 80 , 3 () 4 , 300 , 3 - ( 5 , 2,295 ) () 500 , 5(3+2) - ( 8 , 1,470 ) (Level 1) 6, 100, 2 (Level 2 ) 2 , 500 , 5 () - ( 19, 16, MOU 3) ( 6, , ) - ( 8) () 1, K-ADNI() ( ) 7, - ( 4) K-ADNI(), ('14.09.25, )
2)
IF 20
IF 10
1%
5%
10%
JCR
(/
)
6 1 7 230 34
()
()
() 10 6 3 2
-
121
()* ()
() ()
(3)
23 41 1 4 6 1,193
* , 2014
()
()
() ()
19 1 7 4
3. 2014
4. 2015
4,900
- 2,800( 6, 29)
- 2,100( 2, 5)
(, ) , M.D.-Ph.D.
6,600
- 3,100()
, Imaging Surrogate Marker - 1,500()
-
122 2015 - 2,000()
, , , , 5
: 2,000( 16, 4)
, , ,
5. ()
2012
20132014
2015
2016
*
1998
2012
95,524 95,524
7,840 7,840
103,364 103,364
*
2013
13,833 14,032 13,500 13,500 54,053 1,570 611 611 611 3,403 15,403 14,643 14,111 14,111 58,268
95,524 13,833 14,032 13,500 13,500 150,389 7,840 1,570 611 611 611 11,243 103,364 15,403 14,643 14,111 14,111 161,632
*
6.
-
123 5.
[]
/
1.
/
2.
/,
:
- , , ,
-
2013 1 2015 12
- '15 2015 1 2015 12
6,222(, )
- '15 2,074(, )
-
124 2015 3. 2014 ()
1) (, , , )
- Journal of Psychiatry Neuroscience
- Opto-EEG
- UST 2, 1
()
-() Donders Institute(Robert Oostenveld )
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
1 4 0 2 4 9/25 0
() ()
() ()
(3)
1 2 50
-
125 4. 2014
disease
, NSC 1 SCI 19
,
astrocytic MOR
/ ,
nucleus accumbent
5.
()
6. 2015
1) '15 /
//
-
-
-
/
- Gliotransmitter
-
-
/
- /
-
126 2015 - /
-
- 1. //
2) '15
3)
4)
7.
1)
/
(////
/)
2) /
3) (16 )
4) ()
Axio Cell Observer Z1 System(135, 2013)
NeuroCCD (138, 2013)
5)
UST
8.
/ 14 / 15/ 3 /
OFC mPFC PLC1-KD
OFC mPFC PLC1-KD
-
127
9. ()
2012
2103
2014
2015
2016
/
2013.12015.12
2,074 2,074 2,074 6,222
2,074 2,074 2,074 6,222
2,074 2,074 2,074 6,222
2,074 2,074 2,074 6,222
/ 14 / 15/ 3 /
1.
2.
-
-
-
-
-
128 2015 10.
- /
- ,
-
-
-
- ,
,
-
129
1.
/
2.
(ventral hippocampus, VH)
- , , ,
-
-
2013 1 2015 12
- '15 2015 1 2015 12
572 (, )
- '15 504(, )
-
130 2015 3. 2014 ()
1) (, , , )
-
Cell Neuron (IF 15.982)
- Cell
Neuron (IF 15.982)
-
Nature Protocols (IF 7.78)
()
- ( , RIKEN, IINS,
) 8 CFC 3
- Janelia Farm Research Campus, HHMI
Neuron (IF 15.982)
- New York University Neuron (IF 15.982)
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
0 2 0 2 2 4/6 0
()
()
() 1
-
131
()
()
()
() (3)
12
()
()
()
()
1 1 1
4. 2014
. ,
5.
()
-
132 2015 6. 2015
1) '15 /
-
-
,
-
-
- ,
2) '15
3)
4)
() ETRI, KAERI,
, , KAIST, ,
7.
1)
2
,
2) /
,
3) (16 )
-
133 ,
4) ()
Jinny/Axio Slide Scanner(169, 2014)
NeuroCCD (138, 2013)
5)
8.
/ 14 / 15/ 3 /
10% 30% 70%
9. ()
2012
2103
2014
2015
2016
2013.12015.12
786 572 504 1,862
786 572 504 1,862
786 572 504 1,862
786 572 504 1,862
10.
-
134 2015
1.
/
2.
- S1P1/5
- Nrf2
- ,
2014 1 2018 12
- '15 2015 1 2015 12
5,850 ()
- '15 1,170()
3. 2014 ()
1) (, , , )
-
135
- J. Med. Chem, British J. Pharmacology, Eur. J. Med. Chem.,
Org. Biomol. Chem., PlosOne SCI 12
( )
- : G
- 2014.09.01-2018.03.31
- 15, : 9( )
-
- 2014.12.01-2019.10.31
- 23, : 115
- 4, 4
- PCT 2, 1
- 1, 6
()
-
( , 5/)
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
0 0 0 0 2 12/12 2
-
136 2015
()
()
()
4 4 3
()
()()
()
(3)
1 6 6 30
()
()
()
()
1
4. 2014
Multiple Sclerosis SIPR Nrf2
target .
, . SIP1 SIP5
.
1, ( - )
.
FTY720 KIST PAK1 kinase
( ) .
-
137 1
Nrf
.
5.
()
S1P1/5
Nrf2
6. 2015
1)
- FLIPR
- S1P1/5
- S1P1/5
- Nrf2
- EAE in vivo
2)
- 5
- 5
3)
-
-
-
138 2015 7.
1)
S1P1/5 Nrf2
in vitro/in vivo
ADME/Tox, PK
2) /
3) (16 )
4) ()
Live-cell FRET imaging microscope(1 5,
FRET )
Fluorescence-activated cell sorting(FACS)(4, )
-
139 5)
5/ 2
5
8.
/ 14 / 15/ 3 /
30% 50% 70%
9. ()
2012
2103
2014
2015
2016
2014.12018.12
1,200 1,200 3,600 6,000
1,200 1,200 3,600 6,000
1,200 1,200 3,600 6,000
1,200 1,200 3,600 6,000
10.
, ,
-
140 2015
1.
O
/
2.
(Extracellularvesicle)
-
- RNA
-
-
- miRNA
-
2013 1 2015 12
- '14 2014 1 2014 12
3,900 (, )- '14 1,300 (, )
-
141 3. 2014 ()
1) (, , , )
No SCI
1 SCI
Partially flexible MEMS neural probe composed of polyimide and sucrose gel for reducing brain damage during and
after implantation
Journal of micromechanics
and microengineering
2014.02
2 SCI A multi-channel oscillator for a resonant chemical sensor system
IEEE transactions on industrial electronics
2014.10
3 SCI
Piezoelectric layer embedded-microdiaphragm sensors for
the determination of blood viscosity and density
Applied physics letters 2014.10
4 SCI Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers Lab on a chip 2014.03
5 SCIPressure-driven fast reaction and
recovery of peptide for an electronic nose application
Applied physics letters 2014.02
No /
1 2013.11.25
2 2014.01.243 2014.07.234 2014.10.07
5 2014.06.24
6 PCT 2014.10.28
7 2014.09.02
8 2014.09.16
-
142 2015 - 2()
() - ()
2)
( )
() ()
() ()
(3)
0 2 2 3 20
()
() ()
3 1 2 2 0 0 0 0 0
IF 20
IF 10
1%
5%
10%
JCR
(/
)
0 0 0 0 0 9/11 0
-
143
()
()
()
()
2
4. 2014
, exosome prep, detection, miRNA
, tool
5.
()
miRNA
miRNA
-
144 2015 6. 2015
1) '15 /
-
- miRNA
-
-
- miRNA
-
2) '15
3) 2
4)
- ,
-
7.
1)
2) /
3) (16 )
4) ()
RIE(384, 2013)
E-beam Evaporation System(396, 2013)
(292, 2013)
5)
15: 2, 16: 2, 17: 1, 1
-
145 8.
/ 14 / 15/ 3 /
20% 30% 70%
miRNA 10% 30% 70%
9. ()
2012
2103
2014
2015
2016
2013.12015.12
1,300 1,300 1,300 3,900
1,300 1,300 1,300 3,900
1,300 1,300 1,300 3,900
1,300 1,300 1,300 3,900
10.
ELISA, , NTA
exosome
exosome
1,000 target ID endcoding
miRNA protein profiling, high
throughput drug screening
miRNA
-
146 2015
1.
2.
, , 3D
,
-
-
-
- mGRASP 3D
-
-
/
-
147 2015 1 2017 12
- '15 2015 1 2015 12
10,500 ()
- '15 3,500 ()
3. 2014 ()
4. 2014
5.
6. 2015
1) '15 /
: (mGRASP),
(), ,
- mGRASP
-
-
2) '15
3)
( 17)
4)
- () ETRI, KAERI,
, , KAIST, ,
7.
1)
- ,
-
148 2015 2) /
( , BT IT)
3) (16 )
,
4) ()
Airyscan
Light Sheet Microscopy
Spinning disk confocal microscopy
5)
( 20)
8.
/ 14 / 15/ 3 /
10% 25% 80%
9. ()
2012
2103
2014
2015
2016
2015.12017.12
3,500 7,000 10,500
3,500 7,000 10,500
3,500 7,000 10,500
3,500 7,000 10,500
-
149 10.
-
-
- , ,
-
150 2015 []
Brain Damage , ,,
1.
2.
Brain Damage
-
- ,
, , , ;
-
,
,
/
-
151 ,
2013 2017(1 3)
- '15 2015 1 2015 12
2,144,000()*
- '15 5,000()**
*() (12)**2015 (20,271)
3. 2014 ()
(, , , )
1) (SCI 9)
- - DHED
(Korean J Physiol Pharmacol. 14.2)
- S100A9 (Tg2576)
(PLoS One. 14.2)
- MAP2
(Rev Neurosci, '14.4)
- RNAi (Nat Commun, '14.4)
- III -G-GPR56-RhoA
(PLoS One. 14.6)
- VEGFR2
-1 (eLife, '14.9)
- (Am J Pathol, '14.9)
- TGF
(J Neurosci. '14.11)
- 5
(J Neurosci, '14.12)
-
152 2015 2)
()
1 S100A9 NRF2014.05.012015.04.30 45,630
2 GPR - NRF2014.06.012015.05.31 45,630
3 synucleins NRF 2014.06.012015.05.31 50,916
4 ALS/FTD , TDP-43 NRF2014.06.012015.05.31 49,810
5 ,
2014.08.202015.08.19 63,500
6 (ASD)
NRF 2014.09.012015.08.31 36,830
7Decoding global networks underlying Tourette symptom subtypes using PET and electrophysiological methodologies
TSA 2014.09.012015.08.31 77,722
8 NRF 2014..11.012015.04.30 24,905
9 NRF2014..11.012015.04.30 24,905
10 NRF2014..11.012015.04.30 24,905
11 CLC-ec2 ,
NRF 2014..11.012015.04.30 24,905
12 NRF2014..11.012015.04.30 24,905
13 RNA NRF2013.12.012014.11.30 54,990
14 -
/
2014.11.012015.03.31 250,000
15 NEDD4 NEDD4L -
NRF 2014.11.012015.07.31 37,995
-
153 ()
- MOU 7 KIST ,
7
() -ETRI- 3 MOU (14.8, 2014 UKC )
- ()
2 ()
(20)
( 17)
2)
( )
IF 20
IF 10
1%
5%
10%
JCR (
/
)
1 5 3 9/16 15
-
154 2015
()
()
() ()
2 1 2 2 7 1
4. 2014
5.
()
Brain Damage
6. 2015
1) '15 /
-
- -
-
- ,
- ,
, /
, ,
,
2) '15
-
155 3)
DGIST, UST, -
-
( )
- , IT, BT, NT
, ,
** UST UST- (2016)
4)
SK ( 1)
KBRI-ETRI-
(MGH)
7.
1)
,
,
-
156 2015 2) /
KIST ETRI , IT
, (*)* ,
IBS -
NIH / NIAID(RML) Dr. Byron Caughey
DGIST, UST, ()
, ETRI, (Exosome, extracellular
vesicle )
3) (16 )
3 ,
- ( )
- ,
- ,
5)
8.
/ 14 / 15/ 3 /
10% 80% 10%
- 20% 80%
- - 100%
30% 80% 100%
-
157
9. ()
/ 14 / 15/ 3 /
10% 50% 100%
- 2% 10% 30%
20% 60% 100%
5% 20% 70%
- 10% 40%
TDP-43 ,
10% 30% 70%
10% 30% 85%
10% 20% 70%
(Exosome, EV )
5% 10% 50%
10% 20% 85%
10% 25% 65%
2013
2013
2014
2015
2016
2013.1
3,000 5,000 5,000 13,000 3,000 5,000 5,000 13,000
3,000 5,000 5,000 13,000 - 3,000 5,000 5,000 13,000
-
158 2015 10.
---
, ,
, ,
-
159
1.
2.
,
,
-
- (Serial Face Block SEM
TIRFM 7 )
- ()
(
)-()-( )
( 10870)
/
-
160 2015
2013 2017(1 3)
- '15 2015 1 2015 12
2,144,000()*
- '15 3,800()*** () ('12)
** 2015 (20,271) ( 3,000,
800)
3. 2014 ()
1) (, , , )
()
- (14)
MOU (3)
- (14.3), (14.11), (14.12)
2)
( )
IF 20
IF 10
1%
5%
10%
JCR (
/
)
-
161
()
()
()
() ()
() ()
(3)
35
()
()
() ()
3
4. 2014
5.
()
6. 2015
1) '15 /
-
162 2015 - ( )
-
- ,
, DB(Brain Library)
-
/
-
()
-
-
- ,
- fMRI, PET/CT
- ,
,
2) '15
3)
4)
-
---
-
163 -
- ()
( , )
-
7.
1)
,
--
2) /
DGMIF,
KISTI
-
164 2015 3) ('16 )
fMRI, PET-CT
8.
9. ()
10.
,
--
,
2013
2013
2014
2015
2016
2013.1
3,000 3,500 3,000 9,500 3,000 3,500 3,000 9,500
()
2014.1
800 800 1,600
800 800 1,600
2016.1
500 500 500 500
3,000 4,300 3,800 45,130 3,000 4,300 3,800 45,130
-
165 []
1.
/
2.
- circulating miRNA
- miRNA
- circulating miRNA
- microRNA
circulating miRNA 1
2 ('08'17)
2012 1 2015. 12
- '15
-
166 2015 1,893()
- '15 300
3. 2014 ()
1) (, , , )
- KO
Cas9 CRISPR (G3, 2014)
-
(Trends in Endo. & Met. 2014)
-
(2014. 06.262019.06.25., 5 (3+2), 15(3/)
- PCT : DYRK1A
(2014 10, PCT/KR2013/000329)
- :
(2014 4, 10-1392942), DYRK1A
(2014 9, 10-1447560)
- : Dyrk1aa
(2014 7
2014-009480)
- (UST , )
- (4)
()
-
167 2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
2/9 1
()
()
() 1 2 1
() ()
() () (3)
1 4 10
4. 2014
2014 :
5.
()
-
168 2015
(inter-organ communication) , ,
6. 2015
1) '15 /
miRNA
- Alzheimer disease
- miRNA
- circulating miRNA 1
2) '15
3) (1)
4)
()
-
169 7.
1)
- microRNA
microRNA hit
- dataset
microRNA
- microRNA
- microRNA /
2) /
()
(microRNA)
KIST/ microRNA
()
3) (16 )
4) ()
5)
(1-2015, 1-2017)
8.
-
170 2015 9.
()
10.
- , AD
miRNA
AD AD
- AD GDP 1%
600
-
2012
2103
2014
2015
2016
2012.012014.12
419 719 755 300 1,893
419 719 755 300 1,893
419 719 755 300 1,893
419 719 755 300 1,893
-
171
/
1.
2.
/
/
- /, /
- / ,
2 (0817)
2012 01 2014 12
- '15
850()
- '15
3. 2014 ()
1) (, , , )
/
-
172 2015 - De novo mutations in the motor domain of KIF1A
cause cognitive impairment, spastic paraparesis, axonal neuropathy
and cerebella atrophy" (2015) Human Mutation 36:69 (IF 5.44)
-
- / PTPRT
(10-2011-0037335)
()
- Montreal (Human Mutation, 2015)
- Georgia Regents /
PTPRT ( )
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
1 1
()
()
()
1
-
173
4. 2014
PTPRT
5.
6. 2015
1) '15 /
2) '15
()
()
() ()
2
()
/
-
174 2015 3)
4)
7.
1)
, , ,
2) /
()
( )
3) (16 )
4) ()
5)
8.
/ 14 / 15/ 3 /
/ 20% 50% 70% 100%
/
30% 70% 100%
/ 10% 30% 70%
-
175 9. ()
10.
( ),
- /
- / /
2012
2103
2014
2015
2016
/
2012.012014.12
284 276 290 850
284 276 290 850
284 276 290 850
284 276 290 850
-
176 2015
1.
:
2.
,
-
-
- ,
-
- /
-
-
- /
/
-
177 2 (0817)
2014. 1 2017. 12
- '15 2015.01 2015.12
8,800(, )
- '15 2,200(, )
3. 2014 ()
1) (, , , )
- Progesterone production is affected by unfolded protein response
(UPR) signaling during the luteal phase in mice / Life sciences
- FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential
Anti-Angiogenic Factor during Zebrafish Vascular Development / PLOS ONE
- Therapeutically Targeting Neuroinflammation and Microglia after
Acute Ischemic Stroke / BioMed Research International
- Mitochondrial ROS govern the LPS-induced pro-inflammatoryresponse in microglia
cells by regulating MAPK and NF-B pathways / Neuroscience Letters
()
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
4
-
178 2015
()
()
() ()
6 1 1
4. 2014
5.
6. 2015
1) '15 /
- DJ-1
-
- DJ-1
-
()
-
179 2) '15
3)
4)
R&D
7.
1)
2) /
SPF
,
, CRISPR/Cas9 design
knockout
3) (16 )
,
/
4) ()
5)
-
180 2015 8.
/ 14 / 15/ 3 /
10% 30% 100%
- 30% 70%
9. ()
2012
2103
2014
2015
2016
2014.1-2017.12
2,200 2,200 4,400 8,800
2,200 2,200 4,400 8,800
2,200 2,200 4,400 8,800
- - - -
2,200 2,200 4,400 8,800
10.
,
,
/ 2
-
181 []
1.
2.
-
-
-
:
()
2015 01 2019 12
- '15 2015 1 2015 12
7,500()
- '15 1,500()
/
-
182 2015 3. 2014 ()
4. 2014
5.
()
-
NDA
-
-
6. 2015
1) '15 /
-
-
,
-
-
183 -
-
-
-
-
-
2) '15
3)
4)
- ()
(KIST)
- ( ,
, , , )
- 12
-
7.
1)
o
-
-
184 2015 2) /
o KIST bio-transformation
3) (16 )
4) ()
5)
8.
/ 14 / 15/ 3 /
30% 100%
9. ()
2012
2103
2014
2015
2016
2015.01.01.~2019.12.31
- - - 1,500 6,000 7,500 - - - - - - - - - 1,500 6,000 7,500
- - - 1,500 6,000 7,500 - - - - - - - - - 1,500 6,000 7,500
10.
-
-
-
185 []
1.
/
2.
- NMR/MRI
- / /
-
-
(14.12.30)
2013. 01. 2015. 12.
- '15 2015. 01. 2015. 12.
3,251()
- '15 1,081()
-
186 2015 3. 2014 ()
1) (, , , )
- NeuroImage(/
IF 5% ) 5
- NeuroImage(/ IF
5% ) 4
- KRISS (3)
- 2014
- 10
- ,
(19) (9)
No. 1 3 2014.03.21 10-2014-0033636
2 2014.04.17 DE 112012 004 490.8
3 2014.04.24 US 14/260,750
4 2014.04.25CN
201280052725.4
5 2014.04.25 US 14/262,251
6 2014.07.07 14/324,472 7 2014.07.16 8 2014.07.30 US 14/446,764
9 2014.08.29 PCT/KR2014/008049 PCT
10 SQUID MEG 2014.09.05 10-2014-0119290
11
2014.09.12 10-2014-0121324
12
2014.09.12 10-2014-0121328
-
187
-
No.
1 2014.03.10 10-1374621
2 2014.04.16 10-1387999
3 2014.05.28 10-1403318
4 2014.05.28 10-1403319
5 2014.06.20 10-1412739
6 SQUID 2014.07.04 10-1418339
7 ECG EEG SQUID 2014.09.04 10-1440458
8 2014.01.08 10-1351424
9GNSS ,
2014.04.15 10-1387659
-
SQUID ( BMP )
- UST 2014
No.
13 SQUID 2014.10.14 PCT/KR2014/009612 PCT
14 2014.10.24 10-2014-0145487
15 2014.10.24 10-2014-0145495
16Thin Film Superconducting Acceleration Measuring Apparatus, SQUID Sensor Module, and Fabrication Method of SQUID Sensor Module
2014.09.05 PCT/KR2014/008351 PCT
17System and Method for Measuring Magnetocardiogram of Small Animal
2014.12.26.
U.S. Patent Application No. 13/504,873
18 12 19 2014.10.30 10-2014-0149486
-
188 2015 ()
()
PTB (Div.8.2) NMR/MRI
-
SQUID NMR NMR
- (Applied Physics Letter)
- (ASC2014, Biomag2014)
- (IEEE Trans. Appl. Supercond.)
PTB (Div.8.2) NMR
- -
NMR
- PTB 2 KRISS (1);
Dr. Burghoff, Dr. Koerber - KRISS 1 PTB
(3); - (Journal of
Magnetic Resonance)
Princeton Univ.
-
- (NeuroImage)
Univ. of Maryland
Tokyo metropolitan Univ.
DBS
Spatial filtering
NPL rf
parametric oscillation
NPL
U. C. Berkeley Spin-locking 2015
Juelich SQUID (1)
2
KAIST
NMR
NMR - (Nature scientific reports)
-
189
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
11/22
()
NMR (T1)
15 - 2 T1- T1-
1
MRI MREIT MRI MREIT
/ 1 2
3D /
2
40
- MRI -
IBS-CAPP ( )
SQUID (2)
MEG
motor
KIST
-
190 2015
()
()
()
8 9 11
()
()()
() (3)
1 17( 10, 7)
()
()
()
()
4 2 5 4 3 1
4. 2014
2014 1(S )
5.
()
-
191
6. 2015
1) '15 /
2) '15
3)
1, 1 (UST)
()
SQUID
1 2 3 4 5 6 7 8 9 10 11 12 DNP MRI / / SQUID
-
192 2015 4)
, , ,
,
KAIST, , , ,
,
KAIST ,
, Impact
3D ,
MEG , KIST motion,
7.
1)
NMR/MRI
-
-
/
/
-
193 - /
-
-
- ,
2) /
(KIST), (IBS),
(KIOM)
3) (16 )
(-
, / ,
)
4) ()
( SQUID : 2015
2014 NTIS )
5)
()
()
()
(3)
2013 0 0 0 2 02014 0 0 0 0 12015 1 1 1 0 22016 1 0 1 0 12017 1 0 1 1 0
-
194 2015 8.
/ 14 / 15/ 3 /
10%/ 30%/realistic phantom 60%/
30%/
50%/
70%/
60%/
70%/
80%/
SQUID
90%/ /
100%/ 100%/
9. ()
2012
2013
2014
2015
2016
13. 1 15. 12
1,072 1,098 1,081 2,500 5,751
1,072 1,098 1,081 2,500 5,751
1,072 1,098 1,081 2,500 5,751
1,072 1,098 1,081 2,500 5,751
-
195 10.
NMR
,
-
196 2015 []
1.
IBS
2.
, , ,
- ,
,
-
-
-
-
-
-
-
19
2012. 07 2016. 12
- '15 2015. 01 2015. 12
*39,712()
- '15 *7,902()* 5
-
197 3. 2014 ()
1) (, , , )
- Proceedings of the National Academy of Sciences
of the United States of America
- Molecular Brain
- Pflgers Archiv - European Journal of Physiology
(LARIAT)
- Nature Methods
7 ( 3 )
- Nature communications
_()
13 KHUPO
6
()
The 7th UK Korea Neuroscience symposium
2014.10.21.~22( KAIST)
The 26th International Conference of Korean Society for Molecular & Cellular Biology
2014.10.21.~23( COEX)
Brain Conference 2014 2014.11.6.~8()
-
198 2015 2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
1 3 - 1 4 11/16 -
()
()
() 1 0 0 0 0 0 0 - 0
() ()
() ()
(3)
4 11
()
()
() ()
3
4. 2014 IBS 17 , IBS 3 ,
5
-
199 5.
6. 2015
1) '15 /
- 5% ,
- 5% ,
2) '15
3)
KAIST, DIGST, UST 2015
5 ()
4)
7.
1)
, .
2) /
IBS
KIST
3) (16 )
2016
-
200 2015 4) ()
( ) ( , )
~50 ~10 3~1 ~50 ~10 3~1
1 10 23 33 2,214.4 1,318.8 3,533.2
2 3 7 10 1,025.6 435.3 1,460.9
3 - 6 6 - 247 247
13 36 49 3,240 2,001.1 5,241.1
* 1
. .
. .
, , . .
. .
cage, SPF
, , Photoactivation . .
. .
, . .
culture media
. . Ti:Sapphire
. .
-
201 5)
o KAIST, DIGST, UST :
5 , 5
8.
9. ()
2012
2103
2014
2015
2016
12.07. ~ 16.12.
9,250 6,670 7,934 7,902 7,956 39,712 - - - - - - 9,250 6,670 7,934 7,902 7,956 39,712
9,250 6,670 7,934 7,902 7,956 39,712 - - - - - - 9,250 6,670 7,934 7,902 7,956 39,712
* 15
10.
-
- , ,
- , ,
-
-
- ,
- ,
-
202 2015
1.
IBS
2.
,
-
-
- /
,
,
19
2012 7 2016 12
- '15 2015. 01 2015. 12
*32,639()
- '15 *5,800()* 5
3. 2014 ()
1)
- Slitrk1 PTPdelta complex ,
Nature Communications
-
203 - (LTD) tau ,
Philosophical Transactions of the Royal Society B.
- NGL-3 ,
Phil. Trans. R. Soc. B.
- 2013 (2014.10)
- 4 (2014.11)
- 2014 AKN outstanding research awards(2014.11)
-
- IBS
-
- 2014.01.01. 2014.12.31.(12)
- 6,000
-
(A pharmaceutical composition for treating autism spectrum disorders which
comprises clioquinol)
- KAIST (),
- KAIST (),
- IBS (), 22
()
()
The 7th UK-Korea Neuroscience Symposium 2014.10.21-22 270 , ,
2013 NeurosplashLearning and Memory 2013.08.22~24 70
2014 NeurosplashLearning and Memory 2014.08.19~21 70
-
204 2015
2 (13~14)
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
1 4 6/15 1
()
()
() 1 0 0 0 0 0 0 0 0
() ()
() ()
(3)
2 2 33
()
()
() ()
0 0 0 0 0 0 0 0 0 0 1
-
205 4. 2014 IBS 17 , IBS 3 ,
5
5.
()
NGL-3
6. 2015
1) '15 /
, ADHD, ,
, ,
2) '15
3)
KAIST 3, 1
4)
-
206 2015 7.
1)
o
- Synaptic adhesion molecule synaptic signaling scaffold
, (knock-in mice)
,
.
o -CA3
- simple system deliberate system
- CA3
- -
- , ADHD, ,
2) /
3) (16 )
4) ()
(1209)
(2213)
20 nm ,
* 1
-
207 5)
o 13 KAIST 7 , 14 KAIST 2
o
8.
9. ()
2012
2103
2014
2015
2016
12.8 ~ 16.12
8,039 6,800 6,000 5,800 6,000 32,639
- - - - - -
8,039 6,800 6,000 5,800 6,000 32,639
8,039 6,800 6,000 5,800 6,000 32,639
- - - - - -
8,039 6,800 6,000 5,800 6,000 32,639
* 15
10.
-
-
-
-
-
208 2015
/
1.
IBS
2.
-
, , ,
-
-
-
:
-
19
2013. 07 2017. 12
- '15 2015. 01 2015. 12
*51,974()
- '15 *12,974()* 5
-
209 3. 2014 ()
1) (, , , )
Nature (IF: 42.351)
Nature Protocols (IF: 7.782)
fMRI f
MRI
NeuroImage (IF: 6.132)
MRI Journal of Cerebral
Blood Flow and Metabolism (IF: 5.339)
Euroscience / ,
2
:
(): (
)
2013 7 2017 12
51,974
12,974
/ 1 (), 1,
3, 1 (2015 3)
1
(GPF)
-
210 2015 ()
2014
()
()
Summer Workshop 2014 2014.08.26.~27 40
4th SKKU-NU Annual Workshop on NANO /BIO/PLASMA at
SKKU2014.11.26~27 20
The 7th UK-KOREA Neuroscience Symposium
(3 )2014.10.21.~23 32
- MIT Chung Lab Brain
whole brain 3
connection ,
- Neuroimaging Lab
MRI, ORIS, Optogenetic, Unit Recording
2)
( )
IF 20
IF 10
1%
5%
10%
JCR
(/
)
1 2 0 4 7 18/19 1
-
211
()
()
() 0 0 0 0 0 0 0 0 0
() ()
() ()
(3)
1 1 2 1 1 2
()
()
() ()
2 2
4. 2014 IBS 17 , IBS 3 ,
5
5.
()
fMRI
fMRI
-
212 2015
6. 2015
1) '15 /
- MRI/fMRI
-
-
-
- LED
/
-
2) '15
3)
2 /
/ (GPF)
4)
7.
1)
-
213
, ,
,
/
,
2013 7 2017 12
51,974
2) /
3) (16 )
:
() (
)
: 2013 7 2017 12
IBS
4) ()
Multiphoton Confocal
Microscope
(m) , 1 . in-vivo ( ) imaging
-
214 2015
* 1
(/)
9.4TanimalMRI ( )
15.2TanimalMRI ( )
3.0TanimalMRI ( )
5)
(2014)
() ()
() () (3)
1 1 2 1 1 2
Super Resolution Confocal
Microscope
, , in vitro
Large Scale Superzoom Confocal
Microscope
, ( 4~6) , , , , , , , neurosphere , , , in vivo 4D
-
215
- ,
- / , /
/
- 2 /
-
- /
8.
/ 14 / 15/ 3 /
0% 5% 20%
9. ()
2012
2103
2014
2015
2016
13.7 ~ 17.12
- 7,000 12,000 12,000 20,000 51,000
- - - - - -
- 7,000 12,000 12,000 20,000 51,000
- 7,000 12,000 12,000 20,000 51,000
- - - - - -
- 7,000 12,000 12,000 20,000 51,000
* 15
-
216 2015 10.
-
,
-
,
-
,
- ,
-
,