蛋白質棕櫚酸酯化作用位置之研究與辨識 Investigation and Identification of Protein ...
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蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋蛋 Investigation and Identification of Protein Palmitoylation Sites ： ：、、
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蛋白質棕櫚酸酯化作用位置之研究與辨識 Investigation and Identification of Protein Palmitoylation Sites. 指導教授：李宗夷 學生姓名：簡婉 竹、陳昱宏、胡堞. 大綱. 背景介紹 動機 與 目的 研究方法 研究成果. 背景介紹. 棕櫚酸酯化作用 ( palmitoylation ) 是什麼 ? 棕櫚酸酯化作用 是 蛋白質轉譯後，蛋白質上的半胱胺酸 ( cysteine ) 與棕櫚酸 ( palmitic acid) 間形成硫酯鍵 ( thioester bond) 的現象。 重要性 : - PowerPoint PPT Presentation
Transcript of 蛋白質棕櫚酸酯化作用位置之研究與辨識 Investigation and Identification of Protein ...
Investigation and Identification of Protein Palmitoylation Sites
Investigation and Identification of Protein Palmitoylation Sites
(palmitoylation)? (cysteine) (palmitic acid) (thioester bond)
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307:UniprotKB/SwissProt version 99/11/30
Cwindow size11PositiveNegative
libsvmsensitivity (Sn)specific (Sp)accuracy (Acc)Mathew correlation coefficient (MCC)
Sn=
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Mcc=
: AAB62PWMAAPCPSSM: SVMQuickRBFRandomForest: Acc (Best accuracy)SnSp (Balanced sensitivity and specificity)B62+AAPCQuickRBF
- SnSpSn-SpAccMCCB62+AAPCQuickRBF94.43%94.36%0.07%94.38%86.50%B62+AAPCSVM86.02%98.78%-12.75%95.27%87.98%B62+AAPCRandomForest42.49%96.97%-54.48%87.83%49.94%:PPAB-palm(Prediction of Palmitoylation site with AAPC and B62)Model: FASTA:
- :http://140.138.150.145/~s971548/site/index.php
CKSAAPCKSAAPX.B. Wang, L.Y. Wu, Y.C. Wang, N.Y. Deng, Prediction of palmitoylation sites using the composition of k-spaced amino acid pairs, (2009) Protein Eng. Des. Sel., 22, 707-712.http://www.aporc.org/doc/wiki/CKSAAP-Palm
- CKSAAPSnSpAccMCCCKSAAP71.38%99.49%93.6%80.02%PPAB94.43%94.36%94.38%85.50%Thank you for listening! Q&A
