é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51...

13
ỮỂẴݧݧẲềẴݧிʮ५औ˟Ҕᅹ ܖٻݧዴҔܖϋޛᨺᑕ⥺䜢䛖䜎䛟䛳䛶Ẽ䜢䜔䛳䛴䛡䛯䛔䚸䛭䛾᪉ἲ䛾䛴䛷䛩 1 䜎䛪䛿 ` ᨺᑕ⥺䛿ఱ䜢䛩䜛䜣䛰䜝䛖? ` ᨺᑕ⥺䛻䛿䛹䜣䛺✀㢮䛜䛒䜛䛾䛰䜝䛖? ` 䝠䝖䛾⣽⬊䛿䛹䜜䜒䛨䜘䛖䛻ᨺᑕ⥺䛻ᙅ䛔䛾? 2 ᨺᑕ⥺䛾㟁㞳స⏝ Ᏻᐃ Ᏻᐃ ỈศᏊ H 2 O 䠄୰ᛶ䠅 H 2 O + + e - 䠄㝧䜲䜸䞁䠅 䠄㝜䜲䜸䞁䠅 䝣䝸䞊䝷䝆䜹䝹 3 䝣䝸䞊䝷䝆䜹䝹 䝣䝸䞊䠄⮬⏤䛺䠅䚸䝷䝆䜹䝹䠄㐣䛺䠅 э 䝣䝸䞊䝷䝆䜹䝹䛂⮬⏤䛷㐣䛺ศᏊ䛃 㟁Ꮚ䜢㣕䜀䛥䜜䚸䛂ᑐ䛻䛺䛳䛶䛚䜙䛪Ᏻᐃ䛃 Ᏻᐃ䛺ศᏊ䛿Ᏻᐃ䛧䛯ᙧ䛻䛺䜚䛯䛜䜛 䜘䛭䛛䜙㟁Ꮚ䜢ዣ䛔䛳䛶䛟䜛 H 2 O + +e - Free radical H 2 O + + H 2 O H 3 O + +OH䛴䜎䜚䚸䛂ᑐ䛻䛺䛳䛶䛔䛺䛔㟁Ꮚ(ᑐ㟁Ꮚ)䜢ᣢ䛳䛶䛔䜛䛾䛷䚸䛾 ศᏊ䛛䜙㟁Ꮚ䜢ዣ䛔䜝䛖䛸䛩䜛ศᏊ䛃 4

Transcript of é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51...

Page 1: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

1

?

?

?

2

H2O

H2O+ + e-

3

H2O++e-

Free radical H2O++ H2O ↓

H3O++OH

( )

4

Page 2: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

β X ↓ → (e-) ↓

Ion radical H2O→H2O++e-

↓ Free radical H2O++ H2O → H3O++OH

2H2O

H3O+ + OH-

5

DNA 2

→ DNA

DNA

2

DNA

2H2O → H3O++OH-

6

7

1. 2. 3.

8

Page 3: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

9

10

11

12

Page 4: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

13

14

= =

isotope 1H 2H 3H

(3H 14C 40K 222Rn 226Ra 238U etc) (11C 18F 99mTc 123I 201Tl etc)

15

B

16

Page 5: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

B

17

131I

18

131I → 95%

→ 131I

19

131I

2

3

TSH

rhTSH

20

Page 6: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

21

22

1 6 CT→2

CT

1 131I 23 24

β-

2 131I

Tg TSH Tg

1 X. 2.15. 4700.0 31.61 10 > 2 X. 9. 3. 18.5 43.04 11

X. 9.30. 44.9 0.32 3 X+1. 3. 4. 4.6 54.48 10 >

X+1. 3.17. 9.1 64.11 4 X+1.12. 2. 0.8 48.97 17

X+1.12.22. 5.3 39.91 X+2. 3.22. 0.3 0.25

5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 X+4. 9.18. 0.1 0.15 1 131I

Page 7: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

131I 131I 4

131I

25

26

131I

500MBq

RI

27 28

Page 8: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

B

29

30

31

32

Page 9: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

33

89Sr

Sr Sr Sr Sr Sr

β β

34

89Sr

Sr Sr Sr Sr Sr

β β

β

35

70 2.2MBq/kg

89Sr

Ant.

RPO

89Sr

36

Page 10: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

2.0MBq/kg

1 2 2 Sr 37

2.0MBq/kg

-4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 300

2

4

6

8

10

12

14WBC

RBC

PLT

Neutro

PSA

Sr Sr

38

α !

α β

2

α

2

100μ

β

2

X

δ 2

32P β cm

39

LET 3-5 DNA

S

7000 1 LET KeV/μ 80 0.2

μ 40 - 100 50 - 12,000 LET, linear energy transfer KassisA. Nucl Med. 2008;38:358-366 40

Page 11: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

( )

DNA DNA

41

223Ra

Ra Ra Ra Ra Ra

α α

42

89Sr 223Ra

223RaCl2 89SrCl2

89Sr 8 5%90%

223Ra 24 1%72 64%

89SrCl2223RaCl2

89Sr

1 2MBq/ 3

223Ra

1 55 Bq/ 4 6

44

Page 12: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

B

45

CD20

Pluripotent stem cell

Lymphoid stem cell

Pre-B-cell B-cell Activated B-cell

Plasma cell

Bone marrow Blood, lymph

Press. Semin Oncol 1999;265(suppl 14):58–65

®

Spies, S. M. Semin. Nucl. Med., 34 1 Suppl. 1 , 10 2004

Cross-Fire Effect Y-90 Zevalin

ADCC

CDC

47

90Y Zevalin

48

Page 13: é î Â ´Í g ô > ¯ g ² Á ´Í g ô0.3 0.25 5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 1 G% 131I $ª ²3 Ü ... r O 4 c ¨ > T T > T R > r O P + à >

49