æ F ä æ ä Biochemistry and Molecular Biologyæ F ä æ äBiochemistry and Molecular Biology 教...
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ঊڠ Biochemistry and Molecular Biology 教 授 水口 裕之 Professor Hiroyuki MIZUGUCHI 06-6879-8185 [email protected] 准教授 櫻井 文教 Associate Professor Fuminori SAKURAI 06-6879-8188 [email protected] 助 教 高山 和雄 Assistant Professor Kazuo TAKAYAMA 06-6879-8187 [email protected] Fax 06-6879-8187 受恒 kj 堕怖窪ｙ木匠台蒙協ｙ癖保背遭猷ｚ‒騒凛さ 妃蒙ｖ銀断染ｕｔっ格Ｒ芸Ｘｄふびデよｙ銀断ぃ塚叢ぃ 保群系視ｕｔっ霊ずＰｖｂ‒Ｚずｖふびデよっ慨拍匠粧 兩ｙｊげｙサまゎそｓｂｑ偕侈ｄぜ潔澄ｙ休保ｖ磁采ｂ ｑＩぜ｠慨拍匠粧兩侈サまゎそｙ休保犀原っ虹ｂｑ保陪 ｂｑＲｊふびデよサまゎそｚ‒従鷹溶Ｑ遇宥企ＺそｊＸ ｓこＧせ‒慨拍匠ｙ系赴蟻蛸ｕｔｙ台零揮協犀原っ爾Ｋ 禅ｒ幌測ｙ契芳潔澄ｓｕｎｑＩぜ｠汎犀原剰ｒｚ‒Ｘｙ すＫｕ斯Ｉ灰倫ｒｙ台零揮協犀原ｖ幌測ｙ槽軽慨拍匠悲 瀕ぃ保埼戴散潔澄ｙ休保っ爾Ｉ‒慨拍匠粧兩さ儒台概兩‒ ニまゐハ班ｙ章岱典ガびべ概歪迄休保ｙｊげｙ契芳潔澄 休保っ爾Ｋｓｓこｖ‒休保ｂｊ潔澄っ江叙ｂｊ簸訟ｙ掘 博Ｐずｙ木匠台蒙協犀原っ陪休ｂｑＩぜ｠ 凩Ｍぁ‒ﾄｫｮ 秋耀さ ｠ｮ 秋耀‒窪佩狛金秋耀っ偕侈ｂ ｊ儒台概兩ｒｚ‒Ｘそず厘木企ｕ金秋耀っ婁背ｙ木企秋 耀ｖ司傳冂Ｔ木企ＺｆぜＸｓＱ幌測ｒＧぜＱ‒酔倔ｙ乾 胎拡匠ｋＶっ侈Ｉｊ様溶ｚ司傳ｙ博ｒ牢添っ擁ＭｑＩ ぜ｠汎犀原剰ｒｚ‒簸訟ｖ休保ｂｊ慨拍匠悲瀕狛っ侈Ｉ ｑ金秋耀Ｐず婁背秋耀ぉｙ木企司傳っ膨脇背ｖ鴫げぜ潔 澄休保っ爾Ｋｓｓこｖ‒金秋耀ｙ木企戴散ｖ隈ｄぜ木匠 台蒙協背蟻蛸っ爾ｎｑＩぜ｠Ｚずｖ‒ギイ ﾄｫｮ 秋耀Ｐず 木企秋耀っ司傳冂Ｔ喋せ裾ｂ‒歪蒙よまテそェハみ膜器 狛へ樋胎さ丿司胎ｙ膜器狛ほさふびデよ銀断膜器狛ｙ視 陶っ婁嘗ｂｊ犀原こ陪休ｂｑＩぜ｠ くｊ‒慨拍匠悲瀕サまゎそｒＧぜぱィオふびデよサま ゎそっ台諦ｖ蛤从ｄぜｓ‒訟秩裂侃さ魚肥裂侃Ｑ弍悲Ｚ そぜｊげ‒Ｘそっ偕侈ｂｊニまゐハ肝侈Ｑ渓鼎ＺそｑＩ ぜ｠ｈＸｒ‒Ｘｙ裂侃肝畔ソぺェらゼｙ蟻霊っ遭げ‒司 旗背ｕニまゐハ侈サまゎそ休保っ爾ｎｑＩぜ｠Ｚずｖぱ ィオふびデよさトべふびデよっ契芳ｓｂｊ神籵佇蟻胎ふ びデよｙ休保さ系赴蟻蛸こ爾ｎｑＩぜ｠ 骸様‒恒怖‒ゎハキま常っもそゥｂｕＩ ﾉﾊﾉgｾﾊｿﾄﾉﾂ ｭｩ{ ｒＧぜズびまド ｭｩ{へﾈﾄｭｩ{ほＱ保台ぃ木企班 ｙ輝波ｖ庭天ｕ株醐っ肩きｄＸｓＱ傭疾Ｚそ峠婁Ｚそｑ Ｉぜ｠汎犀原剰ｒｚ‒系赴未霊ｙ ﾈﾄｭｩ{ ｙ系赴蟻霊 っ爾Ｋｓｓこｖ‒秋耀木企さ群企ｖ隈剱ｄぜ ﾈﾄｭｩ{ っよまテそェハみｂ‒ｈｙ従侈ソぺェらゼｙ蟻霊っ虹ｂ ｑ秋耀ｙ止楚胎貝祥ｙｊげｙ槽ｂＩ戴散系視ｙ蟻蛸っ 爾ｎｑＩぜ｠ＸｙすＫｕ犀原ｚ‒儒台概兩ｙｊげｙ司傳 ｙ冂Ｉ木企戴散溶ｙ休保さ‒慨拍匠粧兩ｙｊげｙ槽軽粧 兩侈慨拍匠Ｏすい漁庶概歪ｙ休澱ｖ頃ＱぜこｙｒＧぜ｠ 怪禅ｙすＫｖ略木肋ｒｚ‒受淡投ｙ台零揮協犀原さ厘倔 概兩っ奨Ｍぜ契芳潔澄休保っ虹ｂｑ‒斯方ｕ冑蓋ぉｙ犀 原陪休っ爾ｎｑＯせ‒略木肋っ淡悲ｒＲぜ騒衆ｙ街腿っ 爾ｎｑＩぜ｠ 1）ヒト iPS 細胞から肝臓細胞、小腸上皮細胞等への分化制御に 関する分子生物学的解析と創薬研究や再生医療研究への応用 2）新規遺伝子導入・発現制御技術の開発と遺伝子治療、再生 医療、ワクチン等への応用 3）ノンコーディング RNA（マイクロ RNA 等）の機能解析と 生命科学研究への応用 4）ゲノム編集技術の開発と遺伝子治療、幹細胞研究への応用 犀原記添 受恒ｙ新侑匯紋 1. Wakabayashi K. et al., A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing, J. Virol., 93, e01265-18 (2019) 2. Deguchi S. et al., Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells. Drug. Metab. Dispos., 47, 632-638 (2019) 3. Toba Y. et al., FGF signal is not required for hepatoblast differentiation of human iPS cells, Sci. Rep., 9:3713 (2019) 4. Negoro R. et al., Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies. Stem Cell Rep., 11, 1539-1550 (2018) 5. Takayama K. et al., Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. Biomaterials, 161, 24-32 (2018) 6. Katayama K. et al., Proteolytic disassembly of viral outer capsid proteins is crucial for reovirus-mediated type-I interferon induction in both reovirus-susceptible and reovirus-refractory tumor cells. J. Immunol., 200, 2987-2999 (2018) 7. Machitani M. , et al., MicroRNA miR-27 inhibits adenovirus infection by suppressing the expression of SNAP25 and TXN2. J. Virol., 91, e00159-17 (2017) 8. Takayama K. , et al., Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system. Nuc. Acid Res., 45, 5198-5207 (2017) 9. Nagamoto Y. et al., Enhancement of survival rate by human iPSC-derived hepatocyte sheet transplantation in acute liver failure mice. J. Hepatol., 64, 1068-1075 (2016) 10. Takayama K. et al., Prediction of inter-individual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes. Proc. Natl. Acad. Sci. USA., 111, 16772-16777 (2014) 11. Blumberg R. et al., Protective mucosal immunity mediated by epithelial CD1d and IL-10, Nature, 509, 497-502 (2014) 教 授 水口 裕之 14
Transcript of æ F ä æ ä Biochemistry and Molecular Biologyæ F ä æ äBiochemistry and Molecular Biology 教...
Biochemistry and Molecular Biology
教 授 水口 裕之 Professor Hiroyuki MIZUGUCHI 06-6879-8185 [email protected]准教授 櫻井 文教 Associate Professor Fuminori SAKURAI 06-6879-8188 [email protected]助 教 高山 和雄 Assistant Professor Kazuo TAKAYAMA 06-6879-8187 [email protected] Fax 06-6879-8187
1）ヒト iPS 細胞から肝臓細胞、小腸上皮細胞等への分化制御に関する分子生物学的解析と創薬研究や再生医療研究への応用
2）新規遺伝子導入・発現制御技術の開発と遺伝子治療、再生医療、ワクチン等への応用
3）ノンコーディング RNA（マイクロ RNA 等）の機能解析と生命科学研究への応用
4）ゲノム編集技術の開発と遺伝子治療、幹細胞研究への応用
1. Wakabayashi K. et al., A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing, J. Virol., 93, e01265-18 (2019)
2. Deguchi S. et al., Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells. Drug. Metab. Dispos., 47, 632-638 (2019)
3. Toba Y. et al., FGF signal is not required for hepatoblast differentiation of human iPS cells, Sci. Rep., 9:3713 (2019)4. Negoro R. et al., Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies. Stem
Cell Rep., 11, 1539-1550 (2018)5. Takayama K. et al., Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. Biomaterials, 161,
24-32 (2018)6. Katayama K. et al., Proteolytic disassembly of viral outer capsid proteins is crucial for reovirus-mediated type-I interferon induction in both
reovirus-susceptible and reovirus-refractory tumor cells. J. Immunol., 200, 2987-2999 (2018)7. Machitani M. , et al., MicroRNA miR-27 inhibits adenovirus infection by suppressing the expression of SNAP25 and TXN2. J. Virol., 91,
e00159-17 (2017)8. Takayama K. , et al., Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system. Nuc. Acid Res.,
45, 5198-5207 (2017)9. Nagamoto Y. et al., Enhancement of survival rate by human iPSC-derived hepatocyte sheet transplantation in acute liver failure mice. J. Hepatol.,
64, 1068-1075 (2016)10. Takayama K. et al., Prediction of inter-individual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes.
Proc. Natl. Acad. Sci. USA., 111, 16772-16777 (2014)11. Blumberg R. et al., Protective mucosal immunity mediated by epithelial CD1d and IL-10, Nature, 509, 497-502 (2014)
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