ПОТРОШЊА АНТИБИОТИКА У СРБИЈИ У ПЕРИОДУ 2004-2011.

2004-2011.

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2004-2011. J01

J01- (2. ) 1000 () 2004-2011

Chart3

37.6633360203

39.9254312889

37.4688419126

46.5331502325

47.984331038

38.720878528

21.1911276568

26.1648413231

J01

DDD/1000 inh/day

J01

J01

Sum of DID 2004Sum of DID 2005Sum of DID 2006Sum of DID 2007Sum of DID 2008Sum of DID 2009Sum of DID 2010Sum of DID 2011

doxycyclineJ01AA025.88142744334.90532410854.40075786225.17428179845.02940647213.61935919591.41487059012.2345091998

tetracyclineJ01AA070.25205055930.26776139470.23149000020.30453001030.28403141960.18987352040.12598003230.0759036458

tigecyclineJ01AA1200000.00005947550.00137345440.00123056730.0008604577

ampicillinJ01CA013.11710078842.88067570242.63609832924.61263469472.99704564292.33357460661.34810338990.5819305812

amoxicillinJ01CA048.91274801069.89307746418.555744275110.144828741210.681230671210.54485401624.78754332536.6118704377

benzylpenicillinJ01CE01000.00215632280.00587665530.00170682430.002747532500

phenoxymethylpenicillinJ01CE021.38869552291.65729576871.3426270281.40252750441.35986071891.09229110780.19157038850

combinations of beta lactamase sensitive penicillinsJ01CE300.30244993230.38723350620.3642460460.18475214550.41053739380.18833165880.14817909070.0917521002

ampicillin and enzyme inhibitorJ01CR010000.00473782140.00032711550.00300139080.00469682180.0017566113

amoxicillin and enzyme inhibitorJ01CR021.10421024221.6089085852.07952091382.98418283813.54992262183.38513878551.78094759223.7929066536

piperacillin and enzyme inhibitorJ01CR050.00074286340.00302622170.00284888090.00650468860.0179713860.00481420090.01087043170.0033005506

cefalexinJ01DB014.80301802524.74288361464.27017064595.13976213955.01846557365.45009643192.47250166792.2570283936

cefazolinJ01DB040.03384568060.04371203320.02725838450.06000869250.07019477460.05072799530.03084872540.0331846114

cefadroxilJ01DB050.07386174550.09911481070.09517922550.13287835230.10508213890.13553861680.03815190750.0093814318

cefuroximeJ01DC020.01406353010.03190972290.09042564270.16307876230.38571889880.48169309640.10981638980.3319445908

cefaclorJ01DC040.41480014140.61059696370.42262103090.4637636770.34426081860.12434440220.13794058280.0614203383

cefprozilJ01DC100000.050598373400.08404043920.16767766440.0108226046

cefotaximeJ01DD010.02651476850.02812641970.02620297230.01210872450.02212281230.01206969830.00794786790.0170433572

ceftazidimeJ01DD020.02024654470.02853485070.02780016060.03903993570.02882310440.03517259520.02234508260.0223625078

ceftriaxoneJ01DD040.34030962410.28548511140.36794068950.47699450250.38451331090.34308198350.41641533350.3048618711

cefiximeJ01DD0800.00419753340.12087729480.43692251780.88445899260.95159619080.67308461940.5361576107

cefoperazoneJ01DD120.000639937800.000011644100000

ceftibutenJ01DD140.01862870660.03104701930.03426205930.04885579040.04732881840.01516896170.02391110630.0295114087

cefepimeJ01DE010.00143491770.00892325650.01065660880.01333215140.01697878160.01182808070.00532065360.0000580527

cefpiromeJ01DE020.00003688430.00001030970.00007901380.00009278930000

meropenemJ01DH020.00436204740.01154137590.01637757970.02133597040.02451507680.03300874960.02082288960.0179841306

ertapenemJ01DH03000.00005544830.00137884890.00389044420.00400247810.00712939970.0057376375

imipennem and enzyme inhibitorJ01DH510.00871265430.01204443560.01163536380.01697858510.01760383240.01142736510.0134657880.0131539191

sulfamethoxazole and trimethoprimJ01EE014.32967345953.89054830663.63915235323.81439808774.5373215990.9007306630.46755169870.6998875025

erithromycinJ01FA011.03541220591.43071095561.17443948981.14651639841.1732978020.86580207110.35706554210.7574573863

midekamycinJ01FA030.03018084230.02712962060.02720676360.03039142450.01789075550.01059438090.02751041230.0665142529

roxithromycinJ01FA060.12156987750.27308268880.26383964760.32644201660.4463119350.15178167970.51337577060.2791884797

clarithomycinJ01FA090.02597678870.1750577640.45200567291.18637608121.33967404511.27653416820.97695621260.8775992691

azithromycinJ01FA100.89784725761.62735389091.58181334092.43101579752.80067250532.16367992011.3059123412.6727141541

clindamycinJ01FF010.04395191420.06404699620.12746935840.24777178870.3156727820.28155752640.28560296050.3426736034

lincomycinJ01FF020.23774897450.11484917890.04409700650.00448007330000

streptomycinJ01GA0100.37102145380.32901173160.24598441940.09995609020.04638683150.04225260860.0046404599

tobramycinJ01GB01000.00006210210.0002078480.00074939190.00217956360.00300897190.0030931389

gentamycinJ01GB031.06667771321.22309803660.9618049861.39577615620.81876019760.97146044540.49665070140.6125125271

amikacinJ01GB060.10372483840.10811631070.11859245520.12649407770.14185363890.12755910880.08161723550.0542652

netilmycinJ01GB070.00067544920.00036925670.00018535570.00036426430.00114384220.00004170080.00049920510.0003462229

ofloxacinJ01MA010.11103177130.16756443040.512390350600.153597457300.24306052660.0273486538

ciprofloxacinJ01MA020.98459080221.18604400331.30527831211.62958117662.00598565471.10275906760.95363987421.2678275667

norfloxacinJ01MA060.32180670850.31125815090.24785759920.4897307610.67215545370.11465163140.25687106140.2746062604

levofloxacinJ01MA1200000000.0902514969

pipemidic acidJ01MB041.46976835971.30736413411.45556963641.44699151661.5735891391.37707514621.01645798660.9369032195

vancomycinJ01XA010.00341742530.0122627810.01568355180.02098828890.0238658640.02628050710.02893458260.0225495353

teicoplaninJ01XA020.00310688340.0027271080.00281474060.00363845380.0022303330.00371188210.00273862280.0016641779

fusidic acidJ01XC010.01007682380000000

metronidazoleJ01XD010.1372272420.08469026930.06130721420.0696121370.0906993410.09553479290.08962951250.0318740103

fosfomycinJ01XX010.00897011210.00670574380.01121682150.01440275430.02304528740.02076685490.02444977540.0351273421

nitroxolineJ01XX0700000.05980080330.07263403150.05597014630.0630801951

linezolidJ01XX0800000000.0004114416

Grand Total37.663336020339.925431288937.468841912646.533150232547.98433103838.72087852821.191127656826.1648413231

20042005200620072008200920102011

J0137.6639.9337.4746.5347.9838.7221.1926.16

20042005200620072008200920102011

J018981010855

J01

J01

DDD/1000 inh/day

J02

J01

PID

J04

ATC20042005200620072008200920102011

D01BA02Terbinafine0.00953829490.01245931020.00900997920.00624063680.00795708470.01397854730.01140989520.0132300076

J02AA01Amphotericin B0.00050103010.0007069530.00091780140.00189025050.00219156770.00148572590.00159638260.0017864026

J02AB02Ketoconazole0.46933653420.3743389780.28565485730.17057641570.37592262580.18717152020.2336010.2415819671

J02AC01Fluconazole0.03484924440.06599489110.04825591650.10113318610.05106152230.05685493040.0774475850.0395803049

J02AC02Itraconazole0.00366463240.0357361060.03548210670.066998510.06538741580.0577393490.05274944170.0625445696

J02AC03Voriconazole0.00122752370.00015538240.00025570910.00013936950.00056408840.00113235140.00087943290.0001713401

J02AC04Posaconazole00000000.0000098633

J02AX04Caspofungin00.00000530210.000023657900.00012623680.00025762560.00029849240.000300296

0.51911725970.48939692280.37960002810.34697836860.50321054140.31862004970.37798222990.3592047512

J05

20042005200620072008200920102011

rifampicinJ04AB020.46209366840.35339402250.30897197660.26591184830.25056750340.25011090970.1176234470.0612014664

isoniazidJ04AC01

pyrazinamideJ04AK01

ethambutolJ04AK 02

ATC20042005200620072008200920102011ATC420042005200620072008200920102011

J05AB01Aciclovir0.03515893970.04073655580.03923013460.040355340.04761482150.03041375810.02839357920.0363721878Nucleosides and nucleotides excl. reverse transcriptase inhibitors (J05AB)0.04507900070.05152392220.040946740.04196237630.05049083580.03153729620.0297836130.0627323297

J05AB04Ribavirin0.00950856780.01016951890.00090669060.00066095670.00156123310.00021376490.00011362550.0254226563Phosphonic acid derivatives (J05AD)

J05AB06Ganciclovir0.0003016640.00024227870.00041068710.00040047860.00038919310.00039332440.00025062240.0000356958Protease inhibitors (J05AE)0.00844991370.02313769910.03072762750.0429653290.04347698720.04712632010.05378950590.0402360439

J05AB14Valganciclovir0.00010982910.00037556880.00039922780.00054560110.00092558820.00051644880.00102578590.0009017898Nucleoside and nucleotide reverse transcriptase inhibitors (J05AF)0.06939844170.06787598750.1034683460.3768800810.14432968030.12363927490.09506642810.0753402463

J05AE01Saquinavir0000.00033404150.01022235950.01430837590.00906799720.015530824Non-nucleoside reverse transcriptase inhibitors (J05AG)0.02705091770.03065304030.02979791660.04237872650.03318735490.06851928190.05145837930.0678258638

J05AE02Indinavir0.00042833370.00054126090.00105351770.00066808290000Neuraminidase inhibitors (J05AH)0.0009210.0244840.0428540.0006940.0000894570.2371230.000376

J05AE03Ritonavir0.000004393200.00000369660.0000061860.00001982520.00003742380.00003782510.0000159066Antivirals for treatment of HIV infections, combinations (J05AR)0.01059851220.00615270030.01437219950.00685898460.01411800780.01677335850.04610400250.0084768239

J05AE04Nelfinavir0.0066556460.00673814580.00760750680.00307318140000Other antivirals (J05AC + J05AX)00.00006627680.00013307590.00042311920.00055758320.00047154020.000665070.0011385096

J05AE06Lopinavir0.00136154090.01585829240.02206290640.03888383720.03323480250.03278052040.04201213140.0196054734J050.16057678610.17940962610.21944590550.51146861670.28616044930.28806707190.27686699880.2557498173

J05AE07Fosamprenavir0000000.00267155220.0050838399

J05AF01Zidovudine0.00217217640.00741932450.00806464720.00700249870.01492464490.00817710580.01183599090.011385096

J05AF02Didanosine0.01804355520.0175316060.00855983140.21403288980.01884631380.01492929950.01152600060.0090615782

J05AF04Stavudine0.01036347790.00987156770.00093670660.00242142940.00095495420.00091164440.00018148520.0002288292

J05AF05Lamivudine0.03095546580.02302359370.05423509160.10028840140.06559929740.06366067140.05163848680.0394244957

J05AF06Abacavir0.00786376660.01002989570.03167206920.05313486150.04400446990.03596055380.01988446460.0152402473

J05AG01Nevirapine0.00718282590.00894737390.00907134190.01233726460.00734894720.02504776630.00824010410.0125010608

J05AG03Efavirenz0.01986809180.02170566640.02072657470.03004146190.02583840770.04347151560.04321827520.055324803

J05AH01Zanamivir000000.00057445570.00037574570

J05AH02Oseltamivir0.00092063820.02448406530.04285377340.00069418760.00008945770.2365485154

J05AR01Zidovudine and lamivudine0.00036243620.00429694870.00842814170.00685898460.01411800780.014954560600.0028180931

J05AR02Lamivudine and abacavir000000.00181879790.04610400250.0056587309

J05AR04Zidovudine, lamivudine and abacavir0.0102360760.00185575160.005944057800000

J05AX07Enfuvirtide00.00006627680.00013307590.00042311920.00055758320.00047154020.00032689880.0005298015

J05AX08Raltegravir0000000.00033817120.0006087081

Grand Total0.16057678610.17940962610.21944590550.51146861670.28616044930.28864152760.27724274450.2557498173

0.045079000720040.00844991370.06939844170.027050917700.01059851220

0.051523922220050.02313769910.06787598750.030653040320050.00615270030.0000662768

0.0409467420060.03072762750.1034683460.029797916620060.01437219950.0001330759

0.041962376320070.0429653290.3768800810.042378726520070.00685898460.0004231192

0.050490835820080.04347698720.14432968030.033187354920080.01411800780.0005575832

0.031537296220090.04712632010.12363927490.068519281920090.01677335850.0004715402

0.02978361320100.05378950590.09506642810.051458379320100.04610400250.00066507

0.062732329720110.04023604390.07534024630.067825863820110.00847682390.0011385096

Nucleosides and nucleotides excl. reverse transcriptase inhibitors (J05AB)

Phosphonic acid derivatives (J05AD)

Protease inhibitors (J05AE)

Nucleoside and nucleotide reverse transcriptase inhibitors (J05AF)

Non-nucleoside reverse transcriptase inhibitors (J05AG)

Neuraminidase inhibitors (J05AH)

Antivirals for treatment of HIV infections, combinations (J05AR)

Other antivirals (J05AC + J05AX)

0.03515893970.00950856780.0003016640.000109829100.00042833370.00000439320.0066556460.001361540900.00217217640.01804355520.01036347790.03095546580.00786376660.00718282590.0198680918000.000362436200.01023607600

0.04073655580.01016951890.00024227870.000375568800.000541260900.00673814580.015858292400.00741932450.0175316060.00987156770.02302359370.01002989570.00894737390.0217056664020050.004296948700.00185575160.00006627680

0.03923013460.00090669060.00041068710.000399227800.00105351770.00000369660.00760750680.022062906400.00806464720.00855983140.00093670660.05423509160.03167206920.00907134190.0207265747020060.008428141700.00594405780.00013307590

0.040355340.00066095670.00040047860.00054560110.00033404150.00066808290.0000061860.00307318140.038883837200.00700249870.21403288980.00242142940.10028840140.05313486150.01233726460.0300414619020070.0068589846000.00042311920

0.04761482150.00156123310.00038919310.00092558820.010222359500.000019825200.033234802500.01492464490.01884631380.00095495420.06559929740.04400446990.00734894720.0258384077020080.0141180078000.00055758320

0.03041375810.00021376490.00039332440.00051644880.014308375900.000037423800.032780520400.00817710580.01492929950.00091164440.06366067140.03596055380.02504776630.04347151560.000574455720090.01495456060.001818797900.00047154020

0.02839357920.00011362550.00025062240.00102578590.009067997200.000037825100.04201213140.00267155220.01183599090.01152600060.00018148520.05163848680.01988446460.00824010410.04321827520.0003757457201000.046104002500.00032689880.0003381712

0.03637218780.02542265630.00003569580.00090178980.01553082400.000015906600.01960547340.00508383990.0113850960.00906157820.00022882920.03942449570.01524024730.01250106080.055324803020110.00281809310.005658730900.00052980150.0006087081

Aciclovir

Ribavirin

Ganciclovir

Valganciclovir

Saquinavir

Indinavir

Ritonavir

Nelfinavir

Lopinavir

Fosamprenavir

Zidovudine

Didanosine

Stavudine

Lamivudine

Abacavir

Nevirapine

Efavirenz

Zanamivir

Oseltamivir

Zidovudine and lamivudine

Lamivudine and abacavir

Zidovudine, lamivudine and abacavir

Enfuvirtide

Raltegravir

J01 (3. ) 1000 () 2004-2011

Chart1

14.80960646215.72945206356.15028205192.399243172.89510777224.34153557861.3375309436

16.4871000045.93812745745.17308550323.70052218592.97223071863.89054830661.8089909598

14.98441046125.52155376444.63224786243.67109057783.52146555363.63915235321.5006789587

19.34902362557.0771298135.47881180875.37301028233.56630345423.89849766471.8774683995

19.06094472737.37410520665.32805489436.11021439984.41739709564.54975261711.2655626109

17.55475329927.74379708473.81060617074.74994974652.59448584520.9007306631.3665557188

8.27320736284.14737967851.54208118973.4664232392.47002944880.46755169870.8440670884

11.08351693463.65065246582.31127330334.99614714542.59693531850.19730314960.8295642511

Penicillins (J01C)

Cephalosporins and other beta-lactams (J01D)

Tetracyclines (J01A)

Macrolides, lincosamides and streptogramins (J01F)

Quinolones (J01M)

Sulfonamides and trimethoprim (J01E)

Other J01 classes

DDD per 1000 inhabitants per day

ATC3

ATC320042005200620072008200920102011

J01A6.15028205195.17308550324.63224786245.47881180875.32805489433.81060617071.54208118972.3112733033J01 - absolut volume of use at ATC3 level, expressed in DDD per 1000 inhabitants per day (DID)

J01C14.809606462116.48710000414.984410461219.349023625519.060944727317.55475329928.273207362811.0835169346

J01D5.72945206355.93812745745.52155376447.0771298137.37410520667.74379708474.14737967853.6506524658

J01E4.34153557863.89054830663.63915235323.89849766474.54975261710.9007306630.46755169870.1973031496

J01F2.399243173.70052218593.67109057785.37301028236.11021439984.74994974653.4664232394.9961471454

J01G1.17428643381.70260505771.40965663061.76882676561.06537401881.14762765020.64234444870.6748575488

J01M2.89510777222.97223071863.52146555363.56630345424.41739709562.59448584522.47002944882.5969353185

J01X0.16324450980.10638590210.0910223280.10864163390.20018859210.21892806860.20172263970.1547067023

Grand Total37.662758041939.970605135637.470599531346.620245047948.106031551638.72087852821.210739705825.6653925684

20042005200620072008200920102011

Penicillins (J01C)14.809606462116.48710000414.984410461219.349023625519.060944727317.55475329928.273207362811.0835169346

Cephalosporins and other beta-lactams (J01D)5.72945206355.93812745745.52155376447.0771298137.37410520667.74379708474.14737967853.6506524658

Tetracyclines (J01A)6.15028205195.17308550324.63224786245.47881180875.32805489433.81060617071.54208118972.3112733033

Macrolides, lincosamides and streptogramins (J01F)2.399243173.70052218593.67109057785.37301028236.11021439984.74994974653.4664232394.9961471454

Quinolones (J01M)2.89510777222.97223071863.52146555363.56630345424.41739709562.59448584522.47002944882.5969353185

Sulfonamides and trimethoprim (J01E)4.34153557863.89054830663.63915235323.89849766474.54975261710.9007306630.46755169870.1973031496

Other J01 classes1.33753094361.80899095981.50067895871.87746839951.26556261091.36655571880.84406708840.8295642511

37.662758041939.970605135637.470599531346.620245047948.106031551638.72087852821.210739705825.6653925684

ATC3

Penicillins (J01C)

Cephalosporins and other beta-lactams (J01D)

Tetracyclines (J01A)

Macrolides, lincosamides and streptogramins (J01F)

Quinolones (J01M)

Sulfonamides and trimethoprim (J01E)

Other J01 classes

DDD per 1000 inhabitants per day

ATC5-DID

J01 - absolut volume of use at ATC5 level, expressed in DDD per 1000 inhabitants per day (DID)

ATC20042005200620072008200920102011

J01AA02Doxycycline5.89754094314.90532410854.40075786225.17428179845.04318566793.61935919591.41487059012.2345091998

J01AA07Tetracycline0.25274110880.26776139470.23149000020.30453001030.28480958790.18987352040.12598003230.0759036458

J01AA12Tigecycline00000.00005963850.00137345440.00123056730.0008604577

J01CA01Ampicillin3.12564079052.88858032072.63609832924.61263469473.00525672692.33357460661.34810338990.5819305812

J01CA04Amoxicillin8.86990787799.94011229928.556912940410.147807277510.711092565510.54485401624.78754332536.6118704377

J01CE01Benzylpenicillin0.01029868870.00010227910.00215632280.00587665530.00171150050.002747532500

J01CE02Phenoxymethylpenicillin1.39250016821.65729576871.3426270281.40252750441.36358636471.09229110780.19157038850

J01CE30Combinations0.30327856230.38723350620.3642460460.18475214550.41166215380.18833165880.14817909070.0917521002

J01CR01Ampicillin and enzyme inhibitor0000.00473782140.00032801170.00300139080.00469682180.0017566113

J01CR02Amoxicillin and enzyme inhibitor1.10723547581.61074960852.07952091382.98418283813.55964843723.38513878551.7822439153.7929066536

J01CR05Piperacillin and enzyme inhibitor0.00074489860.00302622170.00284888090.00650468860.0076589670.00481420090.01087043170.0033005506

J01DB01Cefalexin4.81617697874.74288361464.27017064595.13976213955.03221479445.45009643192.47250166792.2570283936

J01DB04Cefazolin0.03393840850.04371203320.02725838450.06000869250.07038708910.05072799530.03084872540.0331846114

J01DB05Cefadroxil0.07406410650.09911481070.09517922550.13287835230.10537003520.13553861680.03815190750.0093814318

J01DC02Cefuroxime0.01410206030.03190972290.09042564270.16307876230.38677566290.48169309640.10981638980.3319445908

J01DC04Cefaclor0.41593658020.61059696370.42262103090.4637636770.34520399890.12434440220.13794058280.0614203383

J01DC10Cefprozil0000.050598373400.08404043920.16767766440.0108226046

J01DD01Cefotaxime0.02658741170.02812641970.02620297230.01210872450.02218342280.01206969830.00794786790.0170433572

J01DD02Ceftazidime0.02030201470.02853485070.02780016060.03903993570.02890207180.03517259520.02234508260.0223625078

J01DD04Ceftriaxone0.29443671050.28548511140.36794068950.47699450250.3855667720.34308198350.41641533350.3048618711

J01DD08Cefixime00.00419753340.12087729480.43692251780.88688216790.95159619080.67308461940.5361576107

J01DD12Cefoperazone0.000641691100.000011644100000

J01DD14Ceftibuten0.01867974410.03104701930.03426205930.04885579040.04745848640.01516896170.02391110630.0295114087

J01DE01Cefepime0.0014388490.00892325650.01065660880.01333215140.01702529880.01182808070.00532065360.0000580527

J01DE02Cefpirome0.00003698530.00001030970.00007901380.00009278930000

J01DH02Meropenem0.00437399820.01154137590.01637757970.02133597040.02458224140.03300874960.02082288960.0179841306

J01DH03Ertapenem000.00005544830.00137884890.00390110290.00400247810.00712939970.0057376375

J01DH51Imipenem and enzyme inhibitor0.00873652460.01204443560.01163536380.01697858510.01765206210.01142736510.0134657880.0131539191

J01EE01Sulfamethoxazole and trimethoprim4.34153557863.89054830663.63915235323.89849766474.54975261710.9007306630.46755169870.1973031496

J01FA01Erythromycin1.03824895171.43071095561.17465878781.14651639841.17651231650.86580207110.35706554210.7574573863

J01FA06Roxithromycin0.12190294560.27308268880.26383964760.32645871860.44753470740.15178167970.51337577060.2791884797

J01FA09Clarithromycin0.0260479580.16334885490.45200567291.18637608121.3433443851.27653416820.97695621260.8775992691

J01FA10Azithromycin0.90030711311.62735389091.58181334092.43101579752.80834558062.16367992011.3059123412.6727141541

J01FA11Miocamycin0.03026352960.02712962060.02720676360.03039142450.01793977130.01059438090.02751041230.0665142529

J01FF01Clindamycin0.04407233040.06404699620.12746935840.24777178870.3165376390.28155752640.28560296050.3426736034

J01FF02Lincomycin0.23840034160.11484917890.04409700650.00448007330000

J01GA01Streptomycin00.37102145380.32901173160.24598441940.10022994250.04638683150.04225260860.0046404599

J01GB01Tobramycin000.00006210210.0002078480.0007514450.00217956360.00300897190.0030931389

J01GB03Gentamicin1.06960011791.22309803660.9618049861.39577615620.82100337620.97146044540.51496642760.6125125271

J01GB06Amikacin0.10400901610.10811631070.11859245520.12649407770.1422422790.12755910880.08161723550.0542652

J01GB07Netilmicin0.00067729980.00036925670.00018535570.00036426430.0011469760.00004170080.00049920510.0003462229

J01MA01Ofloxacin0.11133596790.16756443040.512390350600.154018272300.24306052660.0273486538

J01MA02Ciprofloxacin0.98728831131.18604400331.30564796741.62958117662.01148150581.10275906760.95363987421.267825688

J01MA06Norfloxacin0.32268837070.31125815090.24785759920.4897307610.67399697550.11465163140.25687106140.2746062604

J01MA12Levofloxacin00000000.0902514969

J01MB04Pipemidic acid1.47379512231.30736413411.45556963641.44699151661.57790034211.37707514621.01645798660.9369032195

J01XA01Vancomycin0.00342678810.0122627810.01568355180.02098828890.023931250.02628050710.02893458260.0225495353

J01XA02Teicoplanin0.00311539540.0027271080.00281474060.00363845380.00223644350.00371188210.00273862280.0016641779

J01XC01Fusidic acid0.01010443150000000

J01XD01Metronidazole0.1376032070.08469026930.06130721420.0696121370.09094783230.09553479290.08962951250.0318740103

J01XX01Fosfomycin0.00899468780.00670574380.01121682150.01440275430.02310842510.02076685490.02444977540.0351273421

J01XX07Nitroxoline00000.05996464120.07263403150.05597014630.0630801951

J01XX08Linezolid00000000.0004114416

Grand Total37.662758041939.970605135637.470599531346.620245047948.106031551638.72087852821.210739705825.6653925684

ATC5-DID %

J01- proportional DID use at ATC5 level (in %)

ATC20042005200620072008200920102011

J01AA02Doxycycline15.658813240912.272328857411.744562182711.09878721810.48347890129.34730650116.67053865048.7063121823

J01AA07Tetracycline0.67106372960.66989577410.61779102320.65321409180.59204548510.49036470150.59394454890.2957431708

J01AA12Tigecycline00000.0001239730.00354706410.00580162370.0033525992

J01CA01Ampicillin8.29902257047.22676154367.03511115969.89405930836.24715161486.02665718176.35575849132.2673745575

J01CA04Amoxicillin23.550871840224.868555943622.836338482621.766953964122.265591694127.232992682722.57131713325.7618129943

J01CE01Benzylpenicillin0.02734448890.00025588570.00575470590.0126053720.0035577670.007095739100

J01CE02Phenoxymethylpenicillin3.69728676444.146286413.58314797423.00840869222.83454344652.8209357570.90317636790

J01CE30Combinations0.80524788430.96879570590.97208491620.39629166530.85573916720.48638271120.69860406910.357493461

J01CR01Ampicillin and enzyme inhibitor0000.01016258360.00068185150.00775134990.02214360190.00684428

J01CR02Amoxicillin and enzyme inhibitor2.93986827674.02983543285.54974016926.40104494317.39958862218.74241214098.402554270914.7782919879

J01CR05Piperacillin and enzyme inhibitor0.00197781220.00757111810.00760297650.01395249770.01592101190.0124330880.05124965850.0128599264

J01DB01Cefalexin12.787637520611.865928970711.396056372911.024742864910.46067329214.075342913511.65683847988.7940536565

J01DB04Cefazolin0.09011132030.10936044890.0727460590.12871809750.1463165570.1310094120.14543917760.1292971122

J01DB05Cefadroxil0.19665077740.24796925230.25401041540.28502285250.21903705580.35004013850.17987070710.0365528475

J01DC02Cefuroxime0.03744298370.07983297420.24132424850.34980245630.80400658791.2440138620.51773955711.2933548161

J01DC04Cefaclor1.10437100681.52761501011.12787368280.99476885320.71758984850.32113011610.65033367410.2393118988

J01DC10Cefprozil0000.10853304900.21704166430.7905319040.0421680852

J01DD01Cefotaxime0.0705933740.07036776050.06992941830.02597310360.04611359960.03117103410.03747096030.0664059866

J01DD02Ceftazidime0.05390474780.07138958910.07419192890.08374030580.06007993350.09083625290.10534796480.087130979

J01DD04Ceftriaxone0.78177150540.71423765160.98194502921.0231488530.80149361640.88603873811.96322871931.187832488

J01DD08Cefixime00.01050155090.32259236930.93719481181.84359869082.45757902973.1733198782.0890294557

J01DD12Cefoperazone0.001703781400.000031075400000

J01DD14Ceftibuten0.04959738770.07767462910.09143717930.10479522440.09865392110.03917514860.11273112890.1149852224

J01DE01Cefepime0.00382034960.02232454690.02843992080.0285973430.03539119370.0305470360.02508471520.0002261906

J01DE02Cefpirome0.00009820140.00002579330.00021086890.00019903220000

J01DH02Meropenem0.01161358980.0288746590.04370781320.04576546160.05110012320.08524793560.09817144490.0700715195

J01DH03Ertapenem000.00014797820.00295761830.00810938420.01033674410.03361221630.0223555415

J01DH51Imipenem and enzyme inhibitor0.02319672020.03013323310.03105198180.036418910.03669407260.02951215340.06348570680.0512515794

J01EE01Sulfamethoxazole and trimethoprim11.52739683529.73352365679.71202062078.36224189879.4577591842.3262144282.20431585680.7687517307

J01FA01Erythromycin2.75669920543.5794077943.13488122032.45926720732.44566487532.23600833471.68341862212.9512791759

J01FA06Roxithromycin0.32366972560.68320879280.70412443610.7002509710.930308930.39198924592.42035769491.0878013221

J01FA09Clarithromycin0.06916104750.40867245911.20629421072.5447658632.79246560493.2967593114.60595069343.4193876705

J01FA10Azithromycin2.3904439294.07137666644.22147860125.21450669135.83782426045.58788953766.15684487710.4136889665

J01FA11Miocamycin0.0803539920.06787393010.07260829550.06518932810.03729214550.02736090010.12970039110.2591593044

J01FF01Clindamycin0.11701832990.16023524290.34018499840.53146822460.65799989890.72714653481.34650165171.335158239

J01FF02Lincomycin0.63298694510.28733410090.11768428320.00960971640000

J01GA01Streptomycin00.92823576850.87805302220.52763433390.20835213240.11979798320.19920384310.0180806115

J01GB01Tobramycin000.00016573550.00044583210.00156205990.00562891050.01418607720.0120517889

J01GB03Gentamicin2.83994102813.05999379392.56682571942.99392711211.70665371822.50888017622.42785699472.386530911

J01GB06Amikacin0.27615878790.27048955190.31649468290.27132864180.29568491610.32943237250.38479202830.2114333528

J01GB07Netilmicin0.00179832760.00092382060.00049466980.00078134350.00238426660.0001076960.00235354850.0013489872

J01MA01Ofloxacin0.29561289110.41921914821.367446363300.320164160901.14593140070.1065584862

J01MA02Ciprofloxacin2.62139142912.96729058573.4844597733.49543674624.18134990752.84797016374.49602365314.9398258164

J01MA06Norfloxacin0.85678369690.77871763470.66147220031.05046801141.40106542520.29609770171.21104244791.0699476333


J01MB04Pipemidic acid3.91313647473.27081396353.88456457763.10378359243.28004678663.55641503644.79218547173.6504534929

J01XA01Vancomycin0.00909861170.03067949790.041855620.0450196880.04974688040.06787167060.1364147740.0878596935

J01XA02Teicoplanin0.00827181960.00682278390.00751186420.00780445020.00464898770.00958625490.01291149140.0064841318

J01XC01Fusidic acid0.02682870840000000

J01XD01Metronidazole0.36535616140.21188137890.16361418020.14931739830.18905702550.24672682170.42256665120.1241906204

J01XX01Fosfomycin0.02388218030.01677668820.02993499340.03089377640.04803644030.05363218950.11527073430.1368665687

J01XX07Nitroxoline00000.12465098290.18758363510.2638764470.2457791944

J01XX08Linezolid00000000.0016030987

ATC5-var-DID

J01_ ATC5 level in DID - absolut variation in use over time as compared to the year before (lag time= -1)

ATC20042005200620072008200920102011

J01AA02Doxycycline-0.9922168346-0.50456624630.7735239362-0.1310961304-1.423826472-2.20448860580.8196386097

J01AA07Tetracycline0.0150202859-0.03627139440.07304001-0.0197204224-0.0949360675-0.0638934881-0.0500763865

J01AA12Tigecycline0000.00005963850.0013138159-0.0001428871-0.0003701096

J01CA01Ampicillin-0.2370604698-0.25248199151.9765363655-1.6073779678-0.6716821203-0.9854712167-0.7661728088

J01CA04Amoxicillin1.0702044212-1.38319935871.59089433710.563285288-0.1662385493-5.75731069091.8243271125

J01CE01Benzylpenicillin-0.01019640960.00205404370.0037203325-0.00416515480.001036032-0.00274753250

J01CE02Phenoxymethylpenicillin0.2647956005-0.31466874070.0599004763-0.0389411396-0.2712952569-0.9007207193-0.1915703885

J01CE30Combinations0.0839549439-0.0229874601-0.17949390060.2269100083-0.223330495-0.0401525681-0.0564269905

J01CR01Ampicillin and enzyme inhibitor000.0047378214-0.00440980970.00267337910.001695431-0.0029402104

J01CR02Amoxicillin and enzyme inhibitor0.50351413270.46877130540.90466192430.5754655991-0.1745096517-1.60289487052.0106627386

J01CR05Piperacillin and enzyme inhibitor0.0022813231-0.00017734090.00365580770.0011542784-0.00284476610.0060562308-0.0075698811

J01DB01Cefalexin-0.0732933641-0.47271296870.8695914936-0.10754734510.4178816376-2.9775947641-0.2154732743

J01DB04Cefazolin0.0097736247-0.01645364870.0327503080.0103783966-0.0196590938-0.01987926990.002335886

J01DB05Cefadroxil0.0250507042-0.00393558520.0376991268-0.02750831710.0301685816-0.0973867093-0.0287704757

J01DC02Cefuroxime0.01780766250.05851591990.07265311960.22369690060.0949174335-0.37187670660.222128201

J01DC04Cefaclor0.1946603835-0.18797593280.0411426461-0.1185596781-0.22085959680.0135961807-0.0765202445

J01DC10Cefprozil000.0505983734-0.05059837340.08404043920.0836372252-0.1568550598

J01DD01Cefotaxime0.001539008-0.0019234474-0.01409424770.0100746982-0.0101137245-0.00412183040.0090954893

J01DD02Ceftazidime0.008232836-0.00073469020.0112397752-0.0101378640.0062705234-0.01282751260.0000174252

J01DD04Ceftriaxone-0.00895159910.08245557810.109053813-0.0914277305-0.04248478850.07333335-0.1115534624

J01DD08Cefixime0.00419753340.11667976140.3160452230.44995965010.0647140229-0.2785115714-0.1369270087

J01DD12Cefoperazone-0.00064169110.0000116441-0.00001164410000

J01DD14Ceftibuten0.01236727520.003215040.0145937312-0.001397304-0.03228952470.00874214460.0056003024

J01DE01Cefepime0.00748440750.00173335230.00267554250.0036931474-0.0051972181-0.006507427-0.0052626009

J01DE02Cefpirome-0.00002667560.00006870410.0000137755-0.0000927893000

J01DH02Meropenem0.00716737770.00483620370.00495839070.0032462710.0084265082-0.0121858599-0.0028387591

J01DH03Ertapenem00.00005544830.00132340060.0025222540.00010137520.0031269216-0.0013917622

J01DH51Imipenem and enzyme inhibitor0.003307911-0.00040907180.00534322130.000673477-0.0062246970.0020384229-0.000311869

J01EE01Sulfamethoxazole and trimethoprim-0.4509872719-0.25139595340.25934531150.6512549524-3.6490219542-0.4331789643-0.2702485491

J01FA01Erythromycin0.3924620039-0.2560521677-0.02814238940.0299959181-0.3107102454-0.50873652910.4003918442

J01FA06Roxithromycin0.1511797432-0.00924304120.0626190710.1210759887-0.29575302760.3615940909-0.2341872909

J01FA09Clarithromycin0.13730089690.28865681790.73437040830.1569683038-0.0668102168-0.2995779556-0.0993569435

J01FA10Azithromycin0.7270467778-0.045540550.84920245660.3773297831-0.6446656605-0.85776757921.3668018131

J01FA11Miocamycin-0.0031339090.00007714310.0031846609-0.0124516532-0.00734539040.01691603150.0390038405

J01FF01Clindamycin0.01997466580.06342236220.12030243030.0687658503-0.03498011250.0040454340.057070643

J01FF02Lincomycin-0.1235511627-0.0707521724-0.0396169331-0.0044800733000

J01GA01Streptomycin0.3710214538-0.0420097221-0.0830273122-0.1457544769-0.053843111-0.0041342229-0.0376121487

J01GB01Tobramycin00.00006210210.00014574590.0005435970.00142811860.00082940830.000084167

J01GB03Gentamicin0.1534979186-0.26129305060.4339711702-0.574772780.1504570693-0.45649401790.0975460995

J01GB06Amikacin0.00410729460.01047614450.00790162250.0157482014-0.0146831703-0.0459418733-0.0273520355

J01GB07Netilmicin-0.0003080431-0.0001839010.00017890850.0007827118-0.00110527520.0004575042-0.0001529822

J01MA01Ofloxacin0.05622846250.3448259202-0.51239035060.1540182723-0.15401827230.2430605266-0.2157118728

J01MA02Ciprofloxacin0.1987556920.11960396410.32393320920.3819003292-0.9087224382-0.14911919340.3141858138

J01MA06Norfloxacin-0.0114302198-0.06340055170.24187316180.1842662145-0.55934534410.14221942990.017735199


J01MB04Pipemidic acid-0.16643098820.1482055023-0.00857811980.1309088255-0.2008251959-0.3606171596-0.0795547671

J01XA01Vancomycin0.00883599290.00342077080.00530473710.00294296110.00234925720.0026540755-0.0063850474

J01XA02Teicoplanin-0.00038828740.00008763250.0008237133-0.00140201030.0014754386-0.0009732593-0.0010744449

J01XC01Fusidic acid-0.0101044315000000

J01XD01Metronidazole-0.0529129377-0.02338305510.00830492280.02133569530.0045869606-0.0059052805-0.0577555022

J01XX01Fosfomycin-0.0022889440.00451107770.00318593280.0087056709-0.00234157020.00368292050.0106775667

J01XX07Nitroxoline0000.05996464120.0126693903-0.01666388520.0071100488

J01XX08Linezolid0000000.0004114416

Grand Total2.3078470937-2.50000560439.14964551661.4857865037-9.3851530236-17.51013882214.4546528625

ATC5-var%

J01 - ATC5 level - Proportional difference in DID use as compared to the year before (in %-lag time -1)

ATC20042005200620072008200920102011

J01AA02Doxycycline-16.82%-10.29%17.58%-2.53%-28.23%-60.91%57.93%

J01AA07Tetracycline5.94%-13.55%31.55%-6.48%-33.33%-33.65%-39.75%

J01AA12Tigecycline-10.40%-30.08%

J01CA01Ampicillin-7.58%-8.74%74.98%-34.85%-22.35%-42.23%-56.83%

J01CA04Amoxicillin12.07%-13.92%18.59%5.55%-1.55%-54.60%38.11%

J01CE01Benzylpenicillin-99.01%2008.27%172.53%-70.88%60.53%-100.00%

J01CE02Phenoxymethylpenicillin19.02%-18.99%4.46%-2.78%-19.90%-82.46%-100.00%

J01CE30Combinations27.68%-5.94%-49.28%122.82%-54.25%-21.32%-38.08%

J01CR01Ampicillin and enzyme inhibitor-93.08%815.03%56.49%-62.60%

J01CR02Amoxicillin and enzyme inhibitor45.47%29.10%43.50%19.28%-4.90%-47.35%112.82%

J01CR05Piperacillin and enzyme inhibitor306.26%-5.86%128.32%17.75%-37.14%125.80%-69.64%

J01DB01Cefalexin-1.52%-9.97%20.36%-2.09%8.30%-54.63%-8.71%

J01DB04Cefazolin28.80%-37.64%120.15%17.29%-27.93%-39.19%7.57%

J01DB05Cefadroxil33.82%-3.97%39.61%-20.70%28.63%-71.85%-75.41%

J01DC02Cefuroxime126.28%183.38%80.35%137.17%24.54%-77.20%202.27%

J01DC04Cefaclor46.80%-30.79%9.74%-25.56%-63.98%10.93%-55.47%

J01DC10Cefprozil-100.00%99.52%-93.55%

J01DD01Cefotaxime5.79%-6.84%-53.79%83.20%-45.59%-34.15%114.44%

J01DD02Ceftazidime40.55%-2.57%40.43%-25.97%21.70%-36.47%0.08%

J01DD04Ceftriaxone-3.04%28.88%29.64%-19.17%-11.02%21.37%-26.79%

J01DD08Cefixime2779.72%261.46%102.98%7.30%-29.27%-20.34%

J01DD12Cefoperazone-100.00%-100.00%

J01DD14Ceftibuten66.21%10.36%42.59%-2.86%-68.04%57.63%23.42%

J01DE01Cefepime520.17%19.43%25.11%27.70%-30.53%-55.02%-98.91%

J01DE02Cefpirome-72.12%666.40%17.43%-100.00%

J01DH02Meropenem163.86%41.90%30.28%15.22%34.28%-36.92%-13.63%

J01DH03Ertapenem2386.73%182.92%2.60%78.12%-19.52%

J01DH51Imipenem and enzyme inhibitor37.86%-3.40%45.92%3.97%-35.26%17.84%-2.32%

J01EE01Sulfamethoxazole and trimethoprim-10.39%-6.46%7.13%16.71%-80.20%-48.09%-57.80%

J01FA01Erythromycin37.80%-17.90%-2.40%2.62%-26.41%-58.76%112.13%

J01FA06Roxithromycin124.02%-3.38%23.73%37.09%-66.08%238.23%-45.62%

J01FA09Clarithromycin527.11%176.71%162.47%13.23%-4.97%-23.47%-10.17%

J01FA10Azithromycin80.76%-2.80%53.69%15.52%-22.96%-39.64%104.66%

J01FA11Miocamycin-10.36%0.28%11.71%-40.97%-40.94%159.67%141.78%

J01FF01Clindamycin45.32%99.02%94.38%27.75%-11.05%1.44%19.98%

J01FF02Lincomycin-51.83%-61.60%-89.84%-100.00%

J01GA01Streptomycin-11.32%-25.24%-59.25%-53.72%-8.91%-89.02%

J01GB01Tobramycin234.69%261.54%190.05%38.05%2.80%

J01GB03Gentamicin14.35%-21.36%45.12%-41.18%18.33%-46.99%18.94%

J01GB06Amikacin3.95%9.69%6.66%12.45%-10.32%-36.02%-33.51%

J01GB07Netilmicin-45.48%-49.80%96.52%214.87%-96.36%1097.11%-30.65%

J01MA01Ofloxacin50.50%205.79%-100.00%-100.00%-88.75%

J01MA02Ciprofloxacin20.13%10.08%24.81%23.44%-45.18%-13.52%32.95%

J01MA06Norfloxacin-3.54%-20.37%97.59%37.63%-82.99%124.04%6.90%

J01MA12Levofloxacin

J01MB04Pipemidic acid-11.29%11.34%-0.59%9.05%-12.73%-26.19%-7.83%

J01XA01Vancomycin257.85%27.90%33.82%14.02%9.82%10.10%-22.07%

J01XA02Teicoplanin-12.46%3.21%29.26%-38.53%65.97%-26.22%-39.23%

J01XC01Fusidic acid-100.00%

J01XD01Metronidazole-38.45%-27.61%13.55%30.65%5.04%-6.18%-64.44%

J01XX01Fosfomycin-25.45%67.27%28.40%60.44%-10.13%17.73%43.67%

J01XX07Nitroxoline21.13%-22.94%12.70%

J01XX08Linezolid

Grand Total6.13%-6.25%24.42%3.19%-19.51%-45.22%21.00%

J01A- (5. ) 1000 () 2004-2011

Chart15

5.88142744330.25205055930

4.90532410850.26776139470

4.40075786220.23149000020

5.17428179840.30453001030

5.02940647210.28403141960.0000594755

3.61935919590.18987352040.0013734544

1.41487059010.12598003230.0012305673

2.23450919980.07590364580.0008604577

doxycycline J01AA02

tetracycline J01AA07

tigecycline J01AA12

DID

J01

J01


doxycyclineJ01AA025.88142744334.90532410854.40075786225.17428179845.02940647213.61935919591.41487059012.2345091998


tigecyclineJ01AA1200000.00005947550.00137345440.00123056730.0008604577

ampicillinJ01CA013.11710078842.88067570242.63609832924.61263469472.99704564292.33357460661.34810338990.5819305812

amoxicillinJ01CA048.91274801069.89307746418.555744275110.144828741210.681230671210.54485401624.78754332536.6118704377







cefalexinJ01DB014.80301802524.74288361464.27017064595.13976213955.01846557365.45009643192.47250166792.2570283936

cefazolinJ01DB040.03384568060.04371203320.02725838450.06000869250.07019477460.05072799530.03084872540.0331846114

cefadroxilJ01DB050.07386174550.09911481070.09517922550.13287835230.10508213890.13553861680.03815190750.0093814318

cefuroximeJ01DC020.01406353010.03190972290.09042564270.16307876230.38571889880.48169309640.10981638980.3319445908

cefaclorJ01DC040.41480014140.61059696370.42262103090.4637636770.34426081860.12434440220.13794058280.0614203383

cefprozilJ01DC100000.050598373400.08404043920.16767766440.0108226046

cefotaximeJ01DD010.02651476850.02812641970.02620297230.01210872450.02212281230.01206969830.00794786790.0170433572

ceftazidimeJ01DD020.02024654470.02853485070.02780016060.03903993570.02882310440.03517259520.02234508260.0223625078

ceftriaxoneJ01DD040.34030962410.28548511140.36794068950.47699450250.38451331090.34308198350.41641533350.3048618711

cefiximeJ01DD0800.00419753340.12087729480.43692251780.88445899260.95159619080.67308461940.5361576107


ceftibutenJ01DD140.01862870660.03104701930.03426205930.04885579040.04732881840.01516896170.02391110630.0295114087

cefepimeJ01DE010.00143491770.00892325650.01065660880.01333215140.01697878160.01182808070.00532065360.0000580527

cefpiromeJ01DE020.00003688430.00001030970.00007901380.00009278930000

meropenemJ01DH020.00436204740.01154137590.01637757970.02133597040.02451507680.03300874960.02082288960.0179841306

ertapenemJ01DH03000.00005544830.00137884890.00389044420.00400247810.00712939970.0057376375




midekamycinJ01FA030.03018084230.02712962060.02720676360.03039142450.01789075550.01059438090.02751041230.0665142529




clindamycinJ01FF010.04395191420.06404699620.12746935840.24777178870.3156727820.28155752640.28560296050.3426736034

lincomycinJ01FF020.23774897450.11484917890.04409700650.00448007330000


tobramycinJ01GB01000.00006210210.0002078480.00074939190.00217956360.00300897190.0030931389

gentamycinJ01GB031.06667771321.22309803660.9618049861.39577615620.81876019760.97146044540.49665070140.6125125271

amikacinJ01GB060.10372483840.10811631070.11859245520.12649407770.14185363890.12755910880.08161723550.0542652

netilmycinJ01GB070.00067544920.00036925670.00018535570.00036426430.00114384220.00004170080.00049920510.0003462229

ofloxacinJ01MA010.11103177130.16756443040.512390350600.153597457300.24306052660.0273486538


norfloxacinJ01MA060.32180670850.31125815090.24785759920.4897307610.67215545370.11465163140.25687106140.2746062604



vancomycinJ01XA010.00341742530.0122627810.01568355180.02098828890.0238658640.02628050710.02893458260.0225495353

teicoplaninJ01XA020.00310688340.0027271080.00281474060.00363845380.0022303330.00371188210.00273862280.0016641779

fusidic acidJ01XC010.01007682380000000


fosfomycinJ01XX010.00897011210.00670574380.01121682150.01440275430.02304528740.02076685490.02444977540.0351273421

nitroxolineJ01XX0700000.05980080330.07263403150.05597014630.0630801951

linezolidJ01XX0800000000.0004114416

Grand Total37.663336020339.925431288937.468841912646.533150232547.98433103838.72087852821.191127656826.1648413231

20042005200620072008200920102011

J0137.6639.9337.4746.5347.9838.7221.1926.16

20042005200620072008200920102011

J018981010855

20042005200620072008200920102011

ampicillinJ01CA013.122.882.644.613.002.331.350.58

amoxicillinJ01CA048.919.898.5610.1410.6810.544.796.61

benzylpenicillinJ01CE010.000.000.000.010.000.000.000.00

phenoxymethylpenicillinJ01CE021.391.661.341.401.361.090.190.00


ampicillin and enzyme inhibitorJ01CR010.000.000.000.000.000.000.000.00



14.8316.4314.9819.3519.0217.558.2711.08

Penicillins with extended spectrum - J01CA

20042005200620072008200920102011

ampicillinJ01CA013.122.882.644.613.002.331.350.58

amoxicillinJ01CA048.919.898.5610.1410.6810.544.796.61

Penicillins with extended spectrum - J01CAJ01CA12.0312.7711.1914.7613.6812.886.147.19




Beta lactamase sensitive penicillinsJ01CE1.692.041.711.591.771.280.340.09




Combinations of penicillins, incl. beta-lactamase inhibitorsJ01CR1.101.612.083.003.573.391.803.80

20042005200620072008200920102011

Penicillins with extended spectrumJ01CA12.0312.7711.1914.7613.6812.886.147.19



TotalJ01C14.8316.4314.9819.3519.0217.558.2711.08

cefalexinJ01DB014.80301802524.74288361464.27017064595.13976213955.01846557365.45009643192.47250166792.2570283936

cefazolinJ01DB040.03384568060.04371203320.02725838450.06000869250.07019477460.05072799530.03084872540.0331846114

cefadroxilJ01DB050.07386174550.09911481070.09517922550.13287835230.10508213890.13553861680.03815190750.0093814318

cefuroximeJ01DC020.01406353010.03190972290.09042564270.16307876230.38571889880.48169309640.10981638980.3319445908

cefaclorJ01DC040.41480014140.61059696370.42262103090.4637636770.34426081860.12434440220.13794058280.0614203383

cefprozilJ01DC100000.050598373400.08404043920.16767766440.0108226046

cefotaximeJ01DD010.02651476850.02812641970.02620297230.01210872450.02212281230.01206969830.00794786790.0170433572

ceftazidimeJ01DD020.02024654470.02853485070.02780016060.03903993570.02882310440.03517259520.02234508260.0223625078

ceftriaxoneJ01DD040.34030962410.28548511140.36794068950.47699450250.38451331090.34308198350.41641533350.3048618711

cefiximeJ01DD0800.00419753340.12087729480.43692251780.88445899260.95159619080.67308461940.5361576107


ceftibutenJ01DD140.01862870660.03104701930.03426205930.04885579040.04732881840.01516896170.02391110630.0295114087

cefepimeJ01DE010.00143491770.00892325650.01065660880.01333215140.01697878160.01182808070.00532065360.0000580527

cefpiromeJ01DE020.00003688430.00001030970.00007901380.00009278930000

meropenemJ01DH020.00436204740.01154137590.01637757970.02133597040.02451507680.03300874960.02082288960.0179841306

ertapenemJ01DH03000.00005544830.00137884890.00389044420.00400247810.00712939970.0057376375


cefalexinJ01DB014.804.744.275.145.025.452.472.26

cefazolinJ01DB040.030.040.030.060.070.050.030.03

cefadroxilJ01DB050.070.100.100.130.110.140.040.01

First generation cephalosporinsJ01D4.914.894.395.335.195.642.542.30

cefuroximeJ01DC020.010.030.090.160.390.480.110.33

cefaclorJ01DC040.410.610.420.460.340.120.140.06

cefprozilJ01DC100.000.000.000.050.000.080.170.01

Second generation cephalosporinsJ01DC0.430.640.510.680.730.690.420.40

cefotaximeJ01DD010.030.030.030.010.020.010.010.02

ceftazidimeJ01DD020.020.030.030.040.030.040.020.02

ceftriaxoneJ01DD040.340.290.370.480.380.340.420.30

cefiximeJ01DD080.000.000.120.440.880.950.670.54

cefoperazoneJ01DD120.000.000.000.000.000.000.000.00

ceftibutenJ01DD140.020.030.030.050.050.020.020.03

Third generation cephalosporinsJ01DD0.410.380.581.011.371.361.140.91

cefepimeJ01DE010.00143491770.00892325650.01065660880.01333215140.01697878160.01182808070.00532065360.0000580527

cefpiromeJ01DE020.00003688430.00001030970.00007901380.00009278930000

Fourth generation cephalosporinsJ01DE0.0014718020.00893356620.01073562270.01342494070.01697878160.01182808070.00532065360.000058053

meropenemJ01DH020.00436204740.01154137590.01637757970.02133597040.02451507680.03300874960.02082288960.0179841306

ertapenemJ01DH03000.00005544830.00137884890.00389044420.00400247810.00712939970.0057376375


CarbapenemsJ01DH0.01307470180.02358581150.02806839170.03969340440.04600935340.04843859280.04141807740.0368756871

20042005200620072008200920102011

First generation cephalosporinsJ01DE4.914.894.395.335.195.642.542.30

Second generation cephalosporinsJ01DC0.430.640.510.680.730.690.420.40

Third generation cephalosporinsJ01DD0.410.380.581.011.371.361.140.91

Fourth generation cephalosporinsJ01DE0.000.010.010.010.020.010.010.00

CarbapenemsJ01DH0.010.020.030.040.050.050.040.04

5.765.945.527.087.357.744.153.65

Cephalosporins and other beta lactamsJ01D

20042005200620072008200920102011


midekamycinJ01FA030.030.030.030.030.020.010.030.07




MacrolidesJ01FA2.113.533.505.125.784.473.184.65

clindamycinJ01FF010.04395191420.06404699620.12746935840.24777178870.3156727820.28155752640.28560296050.3426736034

lincomycinJ01FF020.23774897450.11484917890.04409700650.00448007330000

LincosamidesJ01FF0.28170088880.17889617510.17156636490.2522518620.3156727820.28155752640.28560296050.3426736034

20042005200620072008200920102011

MacrolidesJ01FA2.113.533.505.125.784.473.184.65

LincosamidesJ01FF0.280.180.170.250.320.280.290.34

20042005200620072008200920102011


tobramycinJ01GB01000.00006210210.0002078480.00074939190.00217956360.00300897190.0030931389

gentamycinJ01GB031.06667771321.22309803660.9618049861.39577615620.81876019760.97146044540.49665070140.6125125271

amikacinJ01GB060.10372483840.10811631070.11859245520.12649407770.14185363890.12755910880.08161723550.0542652

netilmycinJ01GB070.00067544920.00036925670.00018535570.00036426430.00114384220.00004170080.00049920510.0003462229

20042005200620072008200920102011

ofloxacinJ01MA010.11103177130.16756443040.512390350600.153597457300.24306052660.0273486538


norfloxacinJ01MA060.32180670850.31125815090.24785759920.4897307610.67215545370.11465163140.25687106140.2746062604



20042005200620072008200920102011

fluoroquinolonesJ01MA1.4174292821.66486658452.06552626182.11931193762.83173856571.2174106991.45357146211.6600339778

other quinolonesJ01MB1.46976835971.30736413411.45556963641.44699151661.5735891391.37707514621.01645798660.9369032195

2.88719764162.97223071863.52109589823.56630345424.40532770472.59448584522.47002944882.5969371973

20042005200620072008200920102011

doxycyclineJ01AA025.884.914.405.175.033.621.412.23


tigecyclineJ01AA120.000.000.000.000.000.000.000.00

6.135.174.635.485.313.811.542.31

J01

0

0

0

0

0

0

0

0

J01

DDD/1000 inh/day

J02

0

0

0

0

0

0

0

0

J01

PID

J04

000

000

000

000

000

000

000

000

Penicillins with extended spectrum J01CA

Beta lactamase sensitive penicillins J01CE

Combinations of penicillins, incl. beta-lactamase inhibitors J01CR

DID

J05

00000

00000

00000

00000

00000

00000

00000

00000

First generation cephalosporins J01DE

Second generation cephalosporins J01DC

Third generation cephalosporins J01DD

Fourth generation cephalosporins J01DE

Carbapenems J01DH

DID

00000

00000

00000

00000

00000

00000

00000

00000





Carbapenems J01DH

J01D use in%

0

0

0

0

0

0

0

0

sulfamethoxazole and trimethoprim J01EE01

DID

00

00

00

00

00

00

00

00

Macrolides J01FA

Lincosamides J01FF

DID

00000

00000

00000

00000

00000

00000

00000

00000

erithromycin J01FA01

midekamycin J01FA03

roxithromycin J01FA06

clarithomycin J01FA09

azithromycin J01FA10

DID

00000

00000

00000

00000

00000

00000

00000

00000

streptomycin J01GA01

tobramycin J01GB01

gentamycin J01GB03

amikacin J01GB06

netilmycin J01GB07

DID

00

00

00

00

00

00

00

00

fluoroquinolones J01MA

other quinolones J01MB

DID

00000

00000

00000

00000

00000

00000

00000

00000

ofloxacin J01MA01

ciprofloxacin J01MA02

norfloxacin J01MA06

levofloxacin J01MA12

pipemidic acid J01MB04

DID

000

000

000

000

000

000

000

000

doxycycline J01AA02

tetracycline J01AA07

tigecycline J01AA12

DID

ATC20042005200620072008200920102011

D01BA02Terbinafine0.00953829490.01245931020.00900997920.00624063680.00795708470.01397854730.01140989520.0132300076



J02AC01Fluconazole0.03484924440.06599489110.04825591650.10113318610.05106152230.05685493040.0774475850.0395803049




J02AX04Caspofungin00.00000530210.000023657900.00012623680.00025762560.00029849240.000300296

0.51911725970.48939692280.37960002810.34697836860.50321054140.31862004970.37798222990.3592047512

20042005200620072008200920102011

rifampicinJ04AB020.46209366840.35339402250.30897197660.26591184830.25056750340.25011090970.1176234470.0612014664

isoniazidJ04AC01

pyrazinamideJ04AK01

ethambutolJ04AK 02

ATC20042005200620072008200920102011ATC420042005200620072008200920102011









J05AE06Lopinavir0.00136154090.01585829240.02206290640.03888383720.03323480250.03278052040.04201213140.0196054734J050.16057678610.17940962610.21944590550.51146861670.28616044930.28806707190.27686699880.2557498173


J05AF01Zidovudine0.00217217640.00741932450.00806464720.00700249870.01492464490.00817710580.01183599090.011385096

J05AF02Didanosine0.01804355520.0175316060.00855983140.21403288980.01884631380.01492929950.01152600060.0090615782

J05AF04Stavudine0.01036347790.00987156770.00093670660.00242142940.00095495420.00091164440.00018148520.0002288292

J05AF05Lamivudine0.03095546580.02302359370.05423509160.10028840140.06559929740.06366067140.05163848680.0394244957

J05AF06Abacavir0.00786376660.01002989570.03167206920.05313486150.04400446990.03596055380.01988446460.0152402473

J05AG01Nevirapine0.00718282590.00894737390.00907134190.01233726460.00734894720.02504776630.00824010410.0125010608

J05AG03Efavirenz0.01986809180.02170566640.02072657470.03004146190.02583840770.04347151560.04321827520.055324803

J05AH01Zanamivir000000.00057445570.00037574570

J05AH02Oseltamivir0.00092063820.02448406530.04285377340.00069418760.00008945770.2365485154




J05AX07Enfuvirtide00.00006627680.00013307590.00042311920.00055758320.00047154020.00032689880.0005298015

J05AX08Raltegravir0000000.00033817120.0006087081

Grand Total0.16057678610.17940962610.21944590550.51146861670.28616044930.28864152760.27724274450.2557498173

0.045079000720040.00844991370.06939844170.027050917700.01059851220

0.051523922220050.02313769910.06787598750.030653040320050.00615270030.0000662768

0.0409467420060.03072762750.1034683460.029797916620060.01437219950.0001330759

0.041962376320070.0429653290.3768800810.042378726520070.00685898460.0004231192

0.050490835820080.04347698720.14432968030.033187354920080.01411800780.0005575832

0.031537296220090.04712632010.12363927490.068519281920090.01677335850.0004715402

0.02978361320100.05378950590.09506642810.051458379320100.04610400250.00066507

0.062732329720110.04023604390.07534024630.067825863820110.00847682390.0011385096









0.03515893970.00950856780.0003016640.000109829100.00042833370.00000439320.0066556460.001361540900.00217217640.01804355520.01036347790.03095546580.00786376660.00718282590.0198680918000.000362436200.01023607600

0.04073655580.01016951890.00024227870.000375568800.000541260900.00673814580.015858292400.00741932450.0175316060.00987156770.02302359370.01002989570.00894737390.0217056664020050.004296948700.00185575160.00006627680

0.03923013460.00090669060.00041068710.000399227800.00105351770.00000369660.00760750680.022062906400.00806464720.00855983140.00093670660.05423509160.03167206920.00907134190.0207265747020060.008428141700.00594405780.00013307590

0.040355340.00066095670.00040047860.00054560110.00033404150.00066808290.0000061860.00307318140.038883837200.00700249870.21403288980.00242142940.10028840140.05313486150.01233726460.0300414619020070.0068589846000.00042311920

0.04761482150.00156123310.00038919310.00092558820.010222359500.000019825200.033234802500.01492464490.01884631380.00095495420.06559929740.04400446990.00734894720.0258384077020080.0141180078000.00055758320

0.03041375810.00021376490.00039332440.00051644880.014308375900.000037423800.032780520400.00817710580.01492929950.00091164440.06366067140.03596055380.02504776630.04347151560.000574455720090.01495456060.001818797900.00047154020

0.02839357920.00011362550.00025062240.00102578590.009067997200.000037825100.04201213140.00267155220.01183599090.01152600060.00018148520.05163848680.01988446460.00824010410.04321827520.0003757457201000.046104002500.00032689880.0003381712

0.03637218780.02542265630.00003569580.00090178980.01553082400.000015906600.01960547340.00508383990.0113850960.00906157820.00022882920.03942449570.01524024730.01250106080.055324803020110.00281809310.005658730900.00052980150.0006087081

Aciclovir

Ribavirin

Ganciclovir

Valganciclovir

Saquinavir

Indinavir

Ritonavir

Nelfinavir

Lopinavir

Fosamprenavir

Zidovudine

Didanosine

Stavudine

Lamivudine

Abacavir

Nevirapine

Efavirenz

Zanamivir

Oseltamivir




Enfuvirtide

Raltegravir

J01C- (4. ), 1000 () 2004-2011

Chart5

12.0298487991.69114545531.1049531056

12.77375316662.04452927491.6119348068

11.19184260431.70902939692.0823697947

14.75746343591.59315630512.9954253481

13.67827631411.7721049373.5682211234

12.87842862281.28337029913.3929543772

6.13564671520.33974947921.7965148457

7.19380101890.09175210023.7979638155




DID

J01

J01


doxycyclineJ01AA025.88142744334.90532410854.40075786225.17428179845.02940647213.61935919591.41487059012.2345091998


tigecyclineJ01AA1200000.00005947550.00137345440.00123056730.0008604577

ampicillinJ01CA013.11710078842.88067570242.63609832924.61263469472.99704564292.33357460661.34810338990.5819305812

amoxicillinJ01CA048.91274801069.89307746418.555744275110.144828741210.681230671210.54485401624.78754332536.6118704377







cefalexinJ01DB014.80301802524.74288361464.27017064595.13976213955.01846557365.45009643192.47250166792.2570283936

cefazolinJ01DB040.03384568060.04371203320.02725838450.06000869250.07019477460.05072799530.03084872540.0331846114

cefadroxilJ01DB050.07386174550.09911481070.09517922550.13287835230.10508213890.13553861680.03815190750.0093814318

cefuroximeJ01DC020.01406353010.03190972290.09042564270.16307876230.38571889880.48169309640.10981638980.3319445908

cefaclorJ01DC040.41480014140.61059696370.42262103090.4637636770.34426081860.12434440220.13794058280.0614203383

cefprozilJ01DC100000.050598373400.08404043920.16767766440.0108226046

cefotaximeJ01DD010.02651476850.02812641970.02620297230.01210872450.02212281230.01206969830.00794786790.0170433572

ceftazidimeJ01DD020.02024654470.02853485070.02780016060.03903993570.02882310440.03517259520.02234508260.0223625078

ceftriaxoneJ01DD040.34030962410.28548511140.36794068950.47699450250.38451331090.34308198350.41641533350.3048618711

cefiximeJ01DD0800.00419753340.12087729480.43692251780.88445899260.95159619080.67308461940.5361576107


ceftibutenJ01DD140.01862870660.03104701930.03426205930.04885579040.04732881840.01516896170.02391110630.0295114087

cefepimeJ01DE010.00143491770.00892325650.01065660880.01333215140.01697878160.01182808070.00532065360.0000580527

cefpiromeJ01DE020.00003688430.00001030970.00007901380.00009278930000

meropenemJ01DH020.00436204740.01154137590.01637757970.02133597040.02451507680.03300874960.02082288960.0179841306

ertapenemJ01DH03000.00005544830.00137884890.00389044420.00400247810.00712939970.0057376375




midekamycinJ01FA030.03018084230.02712962060.02720676360.03039142450.01789075550.01059438090.02751041230.0665142529




clindamycinJ01FF010.04395191420.06404699620.12746935840.24777178870.3156727820.28155752640.28560296050.3426736034

lincomycinJ01FF020.23774897450.11484917890.04409700650.00448007330000


tobramycinJ01GB01000.00006210210.0002078480.00074939190.00217956360.00300897190.0030931389

gentamycinJ01GB031.06667771321.22309803660.9618049861.39577615620.81876019760.97146044540.49665070140.6125125271

amikacinJ01GB060.10372483840.10811631070.11859245520.12649407770.14185363890.12755910880.08161723550.0542652

netilmycinJ01GB070.00067544920.00036925670.00018535570.00036426430.00114384220.00004170080.00049920510.0003462229

ofloxacinJ01MA010.11103177130.16756443040.512390350600.153597457300.24306052660.0273486538


norfloxacinJ01MA060.32180670850.31125815090.24785759920.4897307610.67215545370.11465163140.25687106140.2746062604



vancomycinJ01XA010.00341742530.0122627810.01568355180.02098828890.0238658640.02628050710.02893458260.0225495353

teicoplaninJ01XA020.00310688340.0027271080.00281474060.00363845380.0022303330.00371188210.00273862280.0016641779

fusidic acidJ01XC010.01007682380000000


fosfomycinJ01XX010.00897011210.00670574380.01121682150.01440275430.02304528740.02076685490.02444977540.0351273421

nitroxolineJ01XX0700000.05980080330.07263403150.05597014630.0630801951

linezolidJ01XX0800000000.0004114416

Grand Total37.663336020339.925431288937.468841912646.533150232547.98433103838.72087852821.191127656826.1648413231

20042005200620072008200920102011

J0137.6639.9337.4746.5347.9838.7221.1926.16

20042005200620072008200920102011

J018981010855

20042005200620072008200920102011

ampicillinJ01CA013.122.882.644.613.002.331.350.58

amoxicillinJ01CA048.919.898.5610.1410.6810.544.796.61







14.8316.4314.9819.3519.0217.558.2711.08

Penicillins with extended spectrum - J01CA

20042005200620072008200920102011

ampicillinJ01CA013.122.882.644.613.002.331.350.58

amoxicillinJ01CA048.919.898.5610.1410.6810.544.796.61

Penicillins with extended spectrum - J01CAJ01CA12.0312.7711.1914.7613.6812.886.147.19









20042005200620072008200920102011

Penicillins with extended spectrumJ01CA12.0312.7711.1914.7613.6812.886.147.19



TotalJ01C14.8316.4314.9819.3519.0217.558.2711.08

J01

J01

DDD/1000 inh/day

J02

J01

PID

J04




DID

J05

ATC20042005200620072008200920102011

D01BA02Terbinafine0.00953829490.01245931020.00900997920.00624063680.00795708470.01397854730.01140989520.0132300076



J02AC01Fluconazole0.03484924440.06599489110.04825591650.10113318610.05106152230.05685493040.0774475850.0395803049




J02AX04Caspofungin00.00000530210.000023657900.00012623680.00025762560.00029849240.000300296

0.51911725970.48939692280.37960002810.34697836860.50321054140.31862004970.37798222990.3592047512

20042005200620072008200920102011

rifampicinJ04AB020.46209366840.35339402250.30897197660.26591184830.25056750340.25011090970.1176234470.0612014664

isoniazidJ04AC01

pyrazinamideJ04AK01

ethambutolJ04AK 02

ATC20042005200620072008200920102011ATC420042005200620072008200920102011









J05AE06Lopinavir0.00136154090.01585829240.02206290640.03888383720.03323480250.03278052040.04201213140.0196054734J050.16057678610.17940962610.21944590550.51146861670.28616044930.28806707190.27686699880.2557498173


J05AF01Zidovudine0.00217217640.00741932450.00806464720.00700249870.01492464490.00817710580.01183599090.011385096

J05AF02Didanosine0.01804355520.0175316060.00855983140.21403288980.01884631380.01492929950.01152600060.0090615782

J05AF04Stavudine0.01036347790.00987156770.00093670660.00242142940.00095495420.00091164440.00018148520.0002288292

J05AF05Lamivudine0.03095546580.02302359370.05423509160.10028840140.06559929740.06366067140.05163848680.0394244957

J05AF06Abacavir0.00786376660.01002989570.03167206920.05313486150.04400446990.03596055380.01988446460.0152402473

J05AG01Nevirapine0.00718282590.00894737390.00907134190.01233726460.00734894720.02504776630.00824010410.0125010608

J05AG03Efavirenz0.01986809180.02170566640.02072657470.03004146190.02583840770.04347151560.04321827520.055324803

J05AH01Zanamivir000000.00057445570.00037574570

J05AH02Oseltamivir0.00092063820.02448406530.04285377340.00069418760.00008945770.2365485154




J05AX07Enfuvirtide00.00006627680.00013307590.00042311920.00055758320.00047154020.00032689880.0005298015

J05AX08Raltegravir0000000.00033817120.0006087081

Grand Total0.16057678610.17940962610.21944590550.51146861670.28616044930.28864152760.27724274450.2557498173

0.045079000720040.00844991370.06939844170.027050917700.01059851220

0.051523922220050.02313769910.06787598750.030653040320050.00615270030.0000662768

0.0409467420060.03072762750.1034683460.029797916620060.01437219950.0001330759

0.041962376320070.0429653290.3768800810.042378726520070.00685898460.0004231192

0.050490835820080.04347698720.14432968030.033187354920080.01411800780.0005575832

0.031537296220090.04712632010.12363927490.068519281920090.01677335850.0004715402

0.02978361320100.05378950590.09506642810.051458379320100.04610400250.00066507

0.062732329720110.04023604390.07534024630.067825863820110.00847682390.0011385096









0.03515893970.00950856780.0003016640.000109829100.00042833370.00000439320.0066556460.001361540900.00217217640.01804355520.01036347790.03095546580.00786376660.00718282590.0198680918000.000362436200.01023607600

0.04073655580.01016951890.00024227870.000375568800.000541260900.00673814580.015858292400.00741932450.0175316060.00987156770.02302359370.01002989570.00894737390.0217056664020050.004296948700.00185575160.00006627680

0.03923013460.00090669060.00041068710.000399227800.00105351770.00000369660.00760750680.022062906400.00806464720.00855983140.00093670660.05423509160.03167206920.00907134190.0207265747020060.008428141700.00594405780.00013307590

0.040355340.00066095670.00040047860.00054560110.00033404150.00066808290.0000061860.00307318140.038883837200.00700249870.21403288980.00242142940.10028840140.05313486150.01233726460.0300414619020070.0068589846000.00042311920

0.04761482150.00156123310.00038919310.00092558820.010222359500.000019825200.033234802500.01492464490.01884631380.00095495420.06559929740.04400446990.00734894720.0258384077020080.0141180078000.00055758320

0.03041375810.00021376490.00039332440.00051644880.014308375900.000037423800.032780520400.00817710580.01492929950.00091164440.06366067140.03596055380.02504776630.04347151560.000574455720090.01495456060.001818797900.00047154020

0.02839357920.00011362550.00025062240.00102578590.009067997200.000037825100.04201213140.00267155220.01183599090.01152600060.00018148520.05163848680.01988446460.00824010410.04321827520.0003757457201000.046104002500.00032689880.0003381712

0.03637218780.02542265630.00003569580.00090178980.01553082400.000015906600.01960547340.00508383990.0113850960.00906157820.00022882920.03942449570.01524024730.01250106080.055324803020110.00281809310.005658730900.00052980150.0006087081

Aciclovir

Ribavirin

Ganciclovir

Valganciclovir

Saquinavir

Indinavir

Ritonavir

Nelfinavir

Lopinavir

Fosamprenavir

Zidovudine

Didanosine

Stavudine

Lamivudine

Abacavir

Nevirapine

Efavirenz

Zanamivir

Oseltamivir




Enfuvirtide

Raltegravir

J01D- (4. ), 1000 () 2004-2011

Chart6

4.91072545140.42886367160.40633958160.0014718020.0130747018

4.88571045850.64250668660.37739093460.00893356620.0235858115

4.39260825580.51304667360.57709482060.01073562270.0280683917

5.33264918430.67744081271.01392147110.01342494070.0396934044

5.19374248720.72997971741.36724703860.01697878160.0460093534

5.6363630440.69007793781.35708942940.01182808070.0484385928

2.54150230080.41543463711.14370400960.00532065360.0414180774

2.29959443680.40418753370.90993675550.00005805270.0368756871





Carbapenems J01DH

DID

J01

J01


doxycyclineJ01AA025.88142744334.90532410854.40075786225.17428179845.02940647213.61935919591.41487059012.2345091998


tigecyclineJ01AA1200000.00005947550.00137345440.00123056730.0008604577

ampicillinJ01CA013.11710078842.88067570242.63609832924.61263469472.99704564292.33357460661.34810338990.5819305812

amoxicillinJ01CA048.91274801069.89307746418.555744275110.144828741210.681230671210.54485401624.78754332536.6118704377







cefalexinJ01DB014.80301802524.74288361464.27017064595.13976213955.01846557365.45009643192.47250166792.2570283936

cefazolinJ01DB040.03384568060.04371203320.02725838450.06000869250.07019477460.05072799530.03084872540.0331846114

cefadroxilJ01DB050.07386174550.09911481070.09517922550.13287835230.10508213890.13553861680.03815190750.0093814318

cefuroximeJ01DC020.01406353010.03190972290.09042564270.16307876230.38571889880.48169309640.10981638980.3319445908

cefaclorJ01DC040.41480014140.61059696370.42262103090.4637636770.34426081860.12434440220.13794058280.0614203383

cefprozilJ01DC100000.050598373400.08404043920.16767766440.0108226046

cefotaximeJ01DD010.02651476850.02812641970.02620297230.01210872450.02212281230.01206969830.00794786790.0170433572

ceftazidimeJ01DD020.02024654470.02853485070.02780016060.03903993570.02882310440.03517259520.02234508260.0223625078

ceftriaxoneJ01DD040.34030962410.28548511140.36794068950.47699450250.38451331090.34308198350.41641533350.3048618711

cefiximeJ01DD0800.00419753340.12087729480.43692251780.88445899260.95159619080.67308461940.5361576107


ceftibutenJ01DD140.01862870660.03104701930.03426205930.04885579040.04732881840.01516896170.02391110630.0295114087

cefepimeJ01DE010.00143491770.00892325650.01065660880.01333215140.01697878160.01182808070.00532065360.0000580527

cefpiromeJ01DE020.00003688430.00001030970.00007901380.00009278930000

meropenemJ01DH020.00436204740.01154137590.01637757970.02133597040.02451507680.03300874960.02082288960.0179841306

ertapenemJ01DH03000.00005544830.00137884890.00389044420.00400247810.00712939970.0057376375




midekamycinJ01FA030.03018084230.02712962060.02720676360.03039142450.01789075550.01059438090.02751041230.0665142529



azithromycinJ01FA100.89784725761.62735389091.58181334

ПОТРОШЊА АНТИБИОТИКА У СРБИЈИ У ПЕРИОДУ 2004-2011.

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Transcript of ПОТРОШЊА АНТИБИОТИКА У СРБИЈИ У ПЕРИОДУ 2004-2011.