利他能錠 10 毫克 - ktgh.com.t · PDF file主成份:Methylphenidate hydrochloride ......
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Transcript of 利他能錠 10 毫克 - ktgh.com.t · PDF file主成份:Methylphenidate hydrochloride ......
1
10 Ritalin Tablets 10 mg (methylphenidate) Methylphenidate hydrochloride Methylphenidate hydrochloride 10 Methylphenidate (INNalpha-phenyl-2-piperidine acetic acid methyl ester) /(ADHD, DSM-IV) ADHD
Ritalin
DSM-IV ICD-10 EEG ADHD
EEG
()/
Ritalin ADHD Ritalin 60
3
027080
2
/ Ritalin
ADHD ADHD (6 6 ) - 5 () 5-10 - 20-30 2-3 40-60 10-15 6
60
methylphenidate
(MAO) 2
(Tourettes)
3
Ritalin/
Ritalin
Ritalin
Ritalin
Ritalin
RitalinRitalin
Ritalin
Ritalin
Ritalin
central nervous stystemCNS(
)/() Ritalin
()
Ritalin /(
)
ADHD
Ritalin
4
( Ritalin)
ADHD ADHD
Ritalin
( Ritalin)
()
( Ritalin)
ADHD
ADHD
ADHD
Ritalin (Tourettes)
methylphenidate ADHD
Ritalin
methylphenidate(serotonergic drugs)
(selective serotonin reuptake inhibitors; SSRIs) -
(serotonin-norepinephrine reuptake inhibitors; SNRIs)
methylphenidate
(
(hallucinations) (delirium))
/
methylphenidate
()
(Priapism)
methylphenidate
5
()
Ritalin
Ritalin
Ritalin
Ritalin
Ritalin
Ritalin
6
Ritalin 6 6
Ritalin
/
6
10%1%
7
()
*
****
**
*
*
8
*
* ADHD Ritalin LA
** ADHD
(NMS)
Ritalin
()
Ritalin
MEDRA
()
methylphenidate
Ritalin
methylphenidate
Raynaud's phenomenon
9
Ritalin
Ritalin
Methylphenidate HCl
Ritalin
Ritalin(
)
Ritalin MAO 2
(psychoactive)( Ritalin) CNS
Ritalin
alpha-2 clonidine
clonidine
methylphenidate ()
Methylphenidate
10
Dopaminergic
Ritalin (dopamine)(
DOPA(tricyclic antidepressants))(
haloperidol)Ritalin
Ritalin
Ritalin P450
P450 Ritalin
Ritalin methylphenidate D L
P450 1A22C82C92C192D62E1 3A
Ritalin CYP2D6 desipramine
Ritalin coumarin (
phenobarbitalphenytoinprimidone)phenylbutazone
4 ethylbiscoumacetate
(n=12)
Ritalin
/
Methylphenidate
Methylphenidate
RitalinMethylphenidate (
)
methylphenidate
2.5()
11
Ritalin
methylphenidateMethylphenidate
()
barbiturate
Ritalin
calcium gluconate
(PD) Ritalin racemate d-methylphenidated-MPH l-methylphenidatel-MPH Ritalin
(striatum) Ritalin
12
L 75 40 dexmethylphenidate hydrachlorideRitalin d QT/QTc intervalQTcF interval < 5 ms90% 10 ms (PK) - (methylphenidate hydrochloride) D 228 % L 53 % 1-2 40 nmol/L (11 ng/ml) - (AUC)(Cmax) methylphenidate (57%)(43%)(10-33%) D 2.651.11 L/kg L 1.800.91 L/kg methylphenidate 0.2%(6 11 ) Methylphenidate Carboxylesterase CES1A1 alpha-phenyl-2-piperidine acetic acid (ritalinic acid) 2 30-50 alpha-phenyl-2-piperidine acetic acid Methylphenidate 0.17 L/hr/Kg( hydroxymethylphenidate hydroxyritalinic acid) Methylphenidate 2 D 0.400.12 L/h/kg L 0.730.28 L/h/kg 48-96 78-97%1-3%(
13
Methylphenidate 200 mg/kg/day (Spina bifida with malrotated hind limbs)AUC(MRHD) 60mg 5.1 MRHD 0.7 300 mg/kg 12 (92 ) 300 mg/kg MRHD 7.5 Methylphenidate 75 mg/kg( MRHD (AUC) 20.9 )(fetuses with short supernumerary ribs) 18 methylphenidate methylphenidate 160 mg/kg/day ( mg/kg MRHD 90 ) methylphenidate 45 mg/kg mg/kg MRHD 26 B6C3F1 methylphenidate () 60 methylphenidate (MRHD 35 )()
B6C3F1
F344 methylphenidate 45 mg/kg/day ( mg/kg MRHD 26 )
3 (Ames)
250 B6C3F1 Big Blue cII
HPRT Pig A locus 28 DNA 9 methylphenidate 100 mg/kg/day( 7 )( 10)( 13-14 ) 50 mg/kg/day ( mg/kg MRHD 29) 100 mg/kg/day ( mg/kg MRHD 58 )
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Calcium phosphate, lactose, wheat starch, gelatin, magnesium stearate, and talc. 4-1000 EXP 30C 99 11 Novartis Farmaceutica S.A. Ronda de Santa Maria 158, 08210 Barbera del Valles, Barcelona, Spain. : Novartis Pharma AG Lichtstrasse 35, 4056 Basel,Switzerland Information issued: IPL 07-Jan-2014, TFDA 02-Jul-2015 TWI- 050617