Louis B. Cady, MD, FAPA – CEO & Founder – Cady Louis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness Institute Wellness Institute Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry

Wellness Medicine & Functional Neuropsychiatry – Evansville, Indiana

TR 90: A Revolutionary Genomic Based Weight Loss Approach

Focus of this review• What most people do not know about why

they are (a) gaining weight and (b) can’t lose weight.

• How does this eating and insulin thing work?

• Why calorie restriction and typical diets don’t work.

• Is the problem “all in your glands”?

• “What is TR 90?”

Calorie restriction

• The foundational principle of the “yo-yo diet”

• The FAILURE of calorie restriction only– Starve yourself – Lose fat and muscle– Go off diet– Put on all the weight, and then some, because

of loss of muscle– Repeat ad infinitum. And get bigger and

heavier.

Techniques of (net) calorie reduction part I: cut calories

• Using diet books, weighing portions, counting calories, increasing activity

• Join Weight Watchers. • Diet pills & supplements• Fen-Phen disaster – heart valve abnormalities• Stimulant problems –

– Stresses adrenals– Potential for adverse cardiac events

• Lap band (surgical complications), muscle with fat loss, toxins

WEIGHT STATS

ADULTS 70%

OVERWEIGHT

CHILDREN 20%

OBESE

OBESITY IS A KILLER

UP TO 40% OF THE WEIGHT LOSS IN TYPICAL DIETS IS MUSCLE LOSS

Muscle

Muscle

Metabolic

Burn

Metabolic

Burn

LEAN MUSCLE = METABOLIC ENGINE

• Traditional calorie restricted diet• Lose lean muscle as well as fat

• Protein heavy, calorie restricted

• Maintain more lean muscle

Metabolic burn = rate at which body burns calories at rest

Muscle

Muscle

Metabolic Burn

Metabolic Burn

Glycemic index

• A measure of how fast a carbohydrate triggers a rise in circulating blood sugar.

• The higher the number, the greater the blood sugar response.

Selenium, the Thyroid, and You

• “T3” is the ACTIVE form of thyroid

• Conversion of T4 to T3 is selenium dependent

• LP & LP Nano have 200% of RDA of selenium

Se+

The Old FDA Food pyramid – R.I.P 2005

June 1, 2011

“Pyramid Power”

USDA Food PyramidZone Food Pyramid

Vegetables

Fruits

Low-fat Protein

Monounsaturated Fat

Grains and Starches(Use in Moderation)

How to lose it?

FAT LOSS SECRET #1

Source: http://win.niddk.nih.gov/statistics/index.htm#overweight

FAT LOSS SECRET #2

Source: http://win.niddk.nih.gov/statistics/index.htm#overweight

FAT LOSS SECRET #3

Source: http://win.niddk.nih.gov/statistics/index.htm#overweight

The top weight loss secret from Tim Ferris

“Consume 30 grams of protein within one hour of waking up.”

ageLOC – a novel mechanism to target and reset “youth gene clusters”

Old Gene Expression

Young Gene ExpressionTARGET

Old Gene Expression

RESET

1 Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland.

“Youth Gene Clusters” – bogus or bonanza?

Comparative genomics of fungal allergens and epitopes show widespread distribution of closely related allergen and epitope

orthologues. Bower P, et al, BMC Genomics. 2006; 7:251.

Yeast species

SPECIFIC genes

Prostate Cancer – more relevant?

Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Ornish, Dean

et al. Proc Natl Acad Sci USA 2008 June 17; 105(24):8369-8374

Pre-invention gene expression

Post-intervention gene expression

TRANSLATION: What you eat talks to your genes and

CHANGES THEIR EXPRESSION.

Comparison of Genetic Profiles of Adipose Tissue in Identical Twins

Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51.

Same DNA

Different Expression of Genes

Normal Weight Twin Overweight Twin

Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to:

• Fat Regulation (storage versus utilization)• Muscle Protein Synthesis

Ghrelin

LeptinInsulin

References:

Gene Expression relates to the Appetite Control Center of the Brain

• Appetite Control• Eating Behavior• Regulation of energy intake

1. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520.

2. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755.

3. De Silva, et al. Cell Metab. 2011;14:700-706.

4. Malik S, et al. Cell Metab. 2008;7:400-409.

5. Farooqi IS, et al. Science. 2007;317:1355

6. Suzuki K, et al. Experimental Diabetes Research. 2012:1-19.

7. Viquerie N, et al. Diabetologia. 2005;48(1):123-131.

8. Mager et al. European Journal of Endocrinology. 2008;158:

9. Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.

Carbohydrates(260g)

Proteins(90g)

Fats(67g)

Normal Calorie Diet – 2000 kcalF

at Burning

Foods

Fat

Sto

ring

Foo

dsF

at Storing

Foods

Carbohydrates(260 g)

Proteins(90 g)

Fats(67 g)

Carbohydrates(260g)

Proteins(90g)

Fats(67g)

Typical Reduced Calorie Diet – 2000 kcalF

at Burning

Foods

Fat

Sto

ring

Foo

dsF

at Storing

Foods

Carbohydrates(180 g)

– 1200 kcal

Fats(33 g)

Proteins(45 g)

Carbohydrates(260g)

Proteins(90g)

Fats(67g)

Fat B

urning F

oods

Fat

Sto

ring

Foo

dsF

at Storing

Foods

Carbohydrates(120 g)

Fats(40 g)

Muscle Retention Eating Plan – 1200 kcal

Proteins(90 g)

Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn

FA

T S

TO

RIN

GF

AT

ST

OR

ING

FA

T B

UR

NIN

GF

AT

BU

RN

ING

Time in Metabolic Burn Zone = Only 3 hours/day

Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2.Layman DL. Nutrition and Metabolism, 2009; 6:12.

Breakfast Lunch Dinner

ZO

NE

S

Eating Protein with Each Meal Accelerates Metabolic Burn

FA

T S

TO

RIN

GF

AT

ST

OR

ING

FA

T B

UR

NIN

GF

AT

BU

RN

ING

Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2.Layman DL. Nutrition and Metabolism, 2009; 6:12.

Breakfast Lunch Dinner

Time in Metabolic Burn Zone = 9 hours/day

ZO

NE

S

The TR90 Eating Plan Based on:Protein Science & Nutrition Science

• Supports metabolically-active lean muscle and inhibits fat storage1

Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.

• An eating plan designed to complement the supplements.

--- previous eating plan, TR 90, Oct 2013 ---

HOW MANY GRAMS?

H - 36

Benefits of low-glycemic eating

78 pounds gone forever!78 pounds gone forever!

Tina Clark

TINA CLARK

DENNY PRETZ

October 5th, 2013

TR 90 – a look back

October 28, 2013 January 28, 2014Jan 29, 2014

Withings WS-50 Smart Body Analyzer

(Start weight: 168.5 lbs – Oct 28th)

10 lbs of total weight loss = 6% body weight

(43.1 lbs – Oct 28th)

7.7lbs of fat loss

10 lbs of total loss= 77% of weight

loss was FAT loss

Pre-TR90 172 -169

Start June 28th-Oct 28th

4 months, 3 lbs= ¾ lb/mo

Oct 28th-Jan 28th

3 mo’s, ll lbs = 3.7 lbs / mo = 5 X the wt. loss rate

TR90 – (done imperfectly) -169-158

Post TR90158 to 155

Jan 28th –April 17th 2.75 mo’s, 3lbs

= 1.1 lbs/mo

“What happens after I finish 3 months of TR-90?”

“When you change the way you look at things, the things that you look at change.”

-John Assaraf

Key down-home principles• Jump start your genes.• Eliminate the junk. Pitch it. If you don’t have it, you can’t eat

it.• Develop a taste for [low glycemic] fruit.• Ostrich jerky (GNC) or balance protein/carb bars• 30 grams of protein in the a.m. within ½ - 1 hour of awakening• Eat real food• Minimize eating out. • NO FAST FOOD!! NO FAST FOOD!!• Axiom: If you’re full of the good stuff, you won’t crave the bad

stuff.

Personal collection Louis B. Cady,

M.D.

The Question: What Will You Do About It?