Platelet Rich Plasma

Art & science

Islam Kassem,BDS,MSc,FDS RCS

Consultant oral & maxillofacial Surgeon

ikassem@dr.com

Angle Face Left New technology of injection

your own blood to get a

Youthful Look .

.

ikassem@dr.com

Why Are Celebrities Injecting Their Faces With Blood?

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ikassem@dr.com

Platelet?

Anuclear piece of cytoplasm

Include hemostasis,

α-granule,lysosomal granule, dense granules

ikassem@dr.com

At least 7 different growth factors that stimulate bone & soft tissue healing

PDGF aa,bb,ab

TGF b1,b2

VEGF

EGF

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Days of operation

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7 days later

PLT exhausted after 7 days

Macrophage by low oxygen tension, acidity, lactate concentration

Secrete same growth factors

Activated until it is down regulated by the restoration of normal oxygen tension

ikassem@dr.com

Day 3rd

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17days

Graft is completely permeated by new capillaries

Initial osteoid formation

Osteoclast resorb osteoid and BMP released

New bone formation and maturation

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Days 14

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The mechanism of growth factor effects on cells

Inactive state

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Activation

activation

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Clinical effects of PRP on bone regeneration

Platelet

RBC

Normal blood PRP

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Trabecular area Native mandible Autogenous BG

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Clinical effects of PRP on soft tissue healing

Split thickness skin graft donor site healing

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6 days

Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue

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6 months Thrombin side : scarring hypo and hyper-pigmentation area PRP side ;less scarring Much less pigmentation change

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Patient discomfort

Patient discomfort decrease

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Epithelization

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6days

↔

↔

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1 months

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Contraindications

Pre-existing coagulation defect

: thrombocytopenia, hypofibrinogenia…

Hypersensitivity to bovine thrombin

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Clinical steps

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Clinical application

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Ridge preservation

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