Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VI

DR OSAMA I NASSIF MD,FRCPCDR OSAMA I NASSIF MD,FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGYDEPARTMENT OF PATHOLOGY

KAUHKAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Etiology of cancer. Chemical carcinogens.

Radiation carcinogenesis.

Viral oncogenesis.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Biology of tumor growth.

• Kinetics of tumor cell growth.

• Tumor angiogenesis.

• Tumor progression and heterogeneity.

• Tumor invasion and spread.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Kinetics Of Tumor Cell Growth

Doubling time : equal or more than that of normal cells.

Growth fraction : cells in replicative pool , rarely >20%.

Production vz loss :

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Tumor Angiogenesis

Tumor-associated angiogenic factors : -bFGF , VEGF……etc. Macrophage derived growth factors: -TNF-α. Weak angiogenic inhibitors: -Angiostatin , thrombospondin ( p53

upregulated) .

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Kinetics Of Tumor Cell Growth

Clinical implications: 1- cancer therapey: Targeting cycling cells.

Effect of radiation & debulking.

2- latent period of tumors :

Months to years.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Tumor Progression and Heterogeneity.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Tumor Invasion and Spread.

Methods of spread : - Direct. -Through blood vessels. -Through lymph

vessels.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHEtiology of Cancer.

Chemical carcinogens.

Radiation carcinogenesis.

Viral oncogenesis.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Chemical Carcinogens.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens.

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical CarcinogensChemical Carcinogens

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Chemical Carcinogens

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Chemical Carcinogens

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Chemotherapy Induced Malignancies