CDKC;1 MAMASFGQLNLEEPPPIWGSRSVDCFEKLEQIGEGTYGQVYMAKEIKTGEIVALKKIRMDCDKC;2 MAAAAFGQLNLEEPPPIWGSRSVDCFEKLEQIGEGTYGQVYMAKEIKTGEIVALKKIRMD

CDKC;1 NEREGFPITAIREIKILKKLHHENVIQLKEIVTSPGRDRDDQGKPDNNKYKGGIYMVFEYCDKC;2 NEREGFPITAIREIKILKKLHHENVIHLKEIVTSPGRDRDDQGKPDNNKYKGGIYMVFEY CDKC;1 MDHDLTGLADRPGLRFTVPQIKCYMKQLLTGLHYCHVNQVLHRDIKGSNLLIDNEGNLKLCDKC;2 MDHDLTGLADRPGLRFTVPQIKCYMKQLLTGLHYCHVNQVLHRDIKGSNLLIDNEGNLKL

CDKC;1 ADFGLARSYSHDHTGNLTNRVITLWYRPPELLLGATKYGPAIDMWSVGCIFAELLHAKPICDKC;2 ADFGLARSYSHDHTGNLTNRVITLWYRPPELLLGATKYGPAIDMWSVGCIFAELLNGKPI CDKC;1 LPGKNEQEQLNKIFELCGSPDEKLWPGVSKMPWFNNFKPARPLKRRVREFFRHFDRHALECDKC;2 LPGKTENEQLNKIYELCGSPDESNWPGVSKMPWYNQMKSSRPLKRRVREIYRHFDRHALE

CDKC;1 LLEKMLVLDPAQRISAKDALDAEYFWTDPLPCDPKSLPTYESSHEFQTKKKRQQQRQNEECDKC;2 LLEKMLVLDPSQRICAKDALDAEYFWTDPLPCDPKSLPTYESSHEFQTKKKRQQMRHNEE

CDKC;1 AAKRQKLQHPPLQHSRLPPLQHG-GQSHAAPHWPAGPNHPTNN--APPQVPAGPSHNFYGCDKC;2 AAKKQKLQHPQQQHSRLPPQQHGVGQSHAAPLWPAGPNHPMNNNAPPPQIPAG-GHYYGG CDKC;1 KPRG-PPGPNRYPPSGNQSGGYN-QSRGGYSSGSYPPQGRGAPYVAGPRGPSGGPYGVGPCDKC;2 KPRGGAPVPNRYPPSGNQTGGYNNQSRGGYSSGAYPPQGRGAPYGAGPRGPSGG-YGVGP

CDKC;1 PNYTQGG-QYGGSGSSGRGQN----QRNQQYGWQQCDKC;2 PNYSQGGGQYGGSGGSGRGQNPMGGARNQQYGWQP

A

CycT1;4 MAGVLAGDCSFGESGVSSYSRNSNEKQDEVARWYFGRKEIEENSPSRLDSIDLKKETYLRCycT1;5 MAGVLAGECSYSESGVSSHSRNSHEKQEEVSRWYFGRKEIEENSPSRLDGIDLKKETYLR

CycT1;4 KSYCTFLQDLGMRLKVPQVTIATAIIFCHRFFIRQSHARNDRRTIATVCMFLAGKVEETPCycT1;5 KSYCTFLQDLGMRLKVPQVTIATAIIFCHRFFFRQSHAKNDRRTIATVCMFLAGKVEETP CycT1;4 RPLKDVIVVSYEIIHKKDPTTAQKIKQKEVYEQQKELILNGEKIVLSTLGFDFNVYHPYKCycT1;5 RPLKDVIFVSYEIINKKDPGASQKIKQKEVYEQQKELILNGEKIVLSTLGFDLNVYHPYK CycT1;4 PLVEAIKKFKVAQNALAQVAWNFVNDGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLPSDCycT1;5 PLVEAIKKFKVAQNALAQVAWNFVNDGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLPSD

CycT1;4 GEKVWWQEFDVTPRQLEDVSNQMLELYEQNRVPASQVSEVESSVGGGSAH----------CycT1;5 GEKVWWQEFDVTPRQLEDVSNQMLELYEQNRVPASQGSEVESSVGGGSAQRPGSRNAVST

CycT1;4 --HVGSR--PSARLTHEHSNSDNLGGSTKATQNRSNDNGSGEAGSVITEQKGERDTETKDCycT1;5 DEHVGSRQTSSVRSTHEQSNSDNHGGSSKGVLNQNNENGGGEAANVSVDNKEEIERETKE

CycT1;4 S-MHTESHPAHK---------SRSGVEAPGEDKIEKAGAHFPED---DKSRIVGTADVTVCycT1;5 SSLHLESHPAHKDNVREAPHNSRPLVEGPGKDNSEREGGELQDDGAVHKSRNVDVGDALI CycT1;4 SQSPKDIKMFRDKVKAKLE-AKKVQGEKTRKKDLVDEDDLIERELEDVELAVEDDKD---CycT1;5 SQSPKDLKLLRDKVKAKREKAKKLLGERTRKKDLMDEDDLIERELEDVQLAVEDEKTKE

CycT1;4 -------IQNKSSMGTEHGEILDGNNLVVNTEEGEMIDD-VSSTMPSRKRKMESPCEKQLCycT1;5 KVQSRPKAENSDLMGTEHGEILDVKGEVKNTEEGEMVNNNVSPMMHSRKRKMGSPPEKQ

CycT1;4 GEGKRRHDNSENVEEGQKTNPGGSSHSYGDREPRRHSQER---CycT1;5 -EGKRRH-NSENGEESHKTSRGSSHH--GDREHRRHSQENNHS

B

Supplemental Figure 1. Sequence comparison of Arabidopsis CDKC and CYCT1 proteins. Alignment of Arabidopsis CDKC;1 and CDKC;2 (A) and Arabidopsis CYCT1;4 and CYCT1;5 (B). Identical amino acid residues in the two proteins are blue and similar amino acid residues are green.