Post on 23-Dec-2015
الرحمن الله بسمالرحيم
الرحمن الله بسمالرحيم
Part 1Part 1
Isthmus
Pyramidal lobe
Right lobe Left lobe
Ciliary bodyChoroid plexusSalivary glandMammary glandGastric mucosa
Placenta
proteins
enzymes
Mechanism of Action Mechanism of Action
Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
I – Effects on Metabolism .
I - 1 . Cell Metabolic activity . a – Mitochondria : # & size .
b – Cell membrane ions transport : stimulation of Na / K pump .
Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
I - 2 . Body metabolic processes .
a – Carbohydrate metabolism : increased =
glucose absorption by GIT , insulin secretion & uptake by cell : glycolysis , gluconeogenesis . b – Fat metabolism : Increased FA oxidation & depletion of fat stores c – Plasma lipids : decrease plasma cholestrol : increased secretion in bile & stools . Increased # of liver LDL receptors .
Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
I - 2 . Body metabolic processes .
a – Carbohydrate metabolism : increased =
glucose absorption by GIT , insulin secretion & uptake by cell : glycolysis , gluconeogenesis . b – Fat metabolism : Increased FA oxidation & depletion of fat stores c – Plasma lipids : decrease plasma cholestrol : increased secretion in bile & stools . Increased # of liver LDL receptors . d – Basal Metabolic Rate : BMR : BEE = normal body wt .
Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
II – Effects on Growth . a - Growth & Development of brain . b - Skeletal growth .
III – Effects on body systems . a – Primary effect . b – Secondary effect .
Stimulate O2 consumption : GIT , endocrine , Respiratory , CVS , …..
Except anterior pituitary , adult brain , testes, uterus, lymph nodes & spleen
Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
Except
anterior pituitary adult brain testes, uterus, lymph nodes & spleen
TSH
Physiologic effects of thyroid HsPhysiologic effects of thyroid Hs
II – Effects on Growth . a - Growth & Development of brain . b - Skeletal growth .
III – Effects on body systems . a – Primary effect .
b – Secondary effect .
CVS : Heart :
Chronotropic : Increased # & affinity of adr. receptors
Inotropic : Enhance response to circulating catecholamines Increased atrial MHC with more ATPase activity .
TRH
TSH
T4
T3Tissues
TSH